CN104800565B - A kind of Chinese medicine and preparation method for the treatment of esophageal carcinoma - Google Patents

Abstract

The invention provides a kind of Chinese medicine and preparation method for the treatment of esophageal carcinoma, Chinese medicine comprises following raw medicinal material: Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae, grand calyx angelica root, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix Rhodiolae Yunnanensis, Schisandra glaucescens Diels., large Herba Lobeliae Chinensis, Radix Pedicularis Henryi, Radix cynanchi wilfordii, Dendrobium densiflorum lindl., Rhizoma Polygonati Cirrhifolii and little Radix Asparagi.Chinese medicine provided by the invention overcomes the deficiency of the operation of existing simple doctor trained in Western medicine, radiotherapy or chemotherapeutic treatment esophageal carcinoma, there is the features such as side effect is little, good effect, cost are low, cure rate is high, have no drug resistance, improving the Chinese medicine in the symptom of esophageal cancer patients, sign, clinical efficacy, quality of life and survival rate with greater advantage, coordinate operation, radiotherapy, chemotherapeutic treatment by it, realize improving clinical efficacy, quality of life and cure rate.

Description

A kind of Chinese medicine and preparation method for the treatment of esophageal carcinoma

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of esophageal carcinoma.

Background technology

Esophageal carcinoma is also called the esophageal carcinoma, it is one of common malignant tumor of digestive tract of the mankind, the whole world about has 300,000 people to die from esophageal carcinoma every year, account for 1/4th of whole mortality of malignant tumors number, country variant and M & M that is regional, not agnate, different sexes have obvious difference.China is the country occurred frequently of esophageal carcinoma, and the general north of its morbidity is more than south, and male is more than women, and age of onset was the highest with 60 ~ 64 years old, and mortality rate is the highest with 50 ~ 65 years old person, accounts for more than 60% of esophageal carcinoma died.

The main method of current western medical treatment esophageal carcinoma has operation, radiotherapy or chemotherapy, wherein, operative treatment remains the prefered method for the treatment of esophageal carcinoma, and the operative treatment survival rate of 5 years is about 25%, but, some complication that esophageal carcinoma Post operation produces, such as: diarrhoea, cough etc., have a strong impact on the life quality of patient, often cause malnutrition, anemia, hypoproteinemia, severe patient disability, even jeopardizes patient vitals.In addition, due in often belonging to when esophageal cancer patients is gone to a doctor, late period, surgical result can not be satisfactory.

Compared with operative treatment, radiotherapy or the chemotherapy survival rate of 5 years only have about 10%, and effect is not ideal, and the organization type of esophageal carcinoma is many with scale cancer, insensitive to chemotherapy.Although radiotherapy has certain curative effect, the survival rate of patient does not significantly improve, and after radiotherapy, local is controlled or recidivist reaches 88.9%.Also easily cause bone marrow depression after radiotherapy, peripheral blood leucocyte declines, and immunologic function such as to be suppressed at the side reaction, greatly affects completing smoothly for the treatment of plan, life in patients is declined, short survival.

Chinese traditional treatment esophageal carcinoma has oneself characteristic, it follow dialectically to combine with differential diagnosis of diseases, righting and the eliminating evil principle combined, and focus on the viewpoint of " organic conception " and " determination of cause of disease according to differentiation of symptoms and signs is examined because opinion is controlled ", thus reach the object of equilibrium between yin and yang disease therapy.In current western medical treatment, many cancer therapy drugs all extract from Chinese medicine.Experimentation shows, the two is in suppression DNA synthesis, Tumor suppression vascularization, Cell differentiation inducing activity, conditioner body immunity function etc., and the anticancer mechanism of its medicine all communicates, consistent.At present, along with going deep into of clinical research, Chinese medicine esophageal carcinoma has achieved good curative effect.Meanwhile, Chinese medicine in blocking treatment precancerous lesion, the generation of prevention esophageal carcinoma, and all show its original advantage in synergism and attenuation in Comprehensive Treatment etc.

Summary of the invention

Technical problem to be solved by this invention is, overcome the deficiency of the operation of existing simple doctor trained in Western medicine, radiotherapy or chemotherapeutic treatment esophageal carcinoma, utilize the theory of Chinese medical science that China is traditional, there is provided that a kind of side effect is little, good effect, cost are low, cure rate is high, have no drug resistance, improving the Chinese medicine in the symptom of esophageal cancer patients, sign, clinical efficacy, quality of life and survival rate with greater advantage, coordinate operation, radiotherapy, chemotherapeutic treatment by it, realize improving clinical efficacy, quality of life and cure rate.

Ask to solve above-mentioned technology, the invention provides a kind of Chinese medicine for the treatment of esophageal carcinoma, it comprises: Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae, grand calyx angelica root, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix Rhodiolae Yunnanensis, Schisandra glaucescens Diels., large Herba Lobeliae Chinensis, Radix Pedicularis Henryi, Radix cynanchi wilfordii, Dendrobium densiflorum lindl., Rhizoma Polygonati Cirrhifolii and little Radix Asparagi.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 40 ~ 50 parts, Herba hypoxis aureae 20 ~ 30 parts, Ramulus et Folium Loranthi Pentapetali 30 ~ 40 parts, Fructus Broussonetiae 30 ~ 40 parts, Herba Melastomatis Dodecandri fruit 10 ~ 20 parts, Fructus Ilicis Purpureae 10 ~ 20 parts, Semen Phaseoli lunati 20 ~ 30 parts, Herba Veronicae peregrinae 15 ~ 25 parts, grand calyx angelica root 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 20 ~ 30 parts, Radix Rhodiolae Yunnanensis 5 ~ 15 parts, Schisandra glaucescens Diels. 10 ~ 20 parts, large Herba Lobeliae Chinensis 20 ~ 30 parts, Radix Pedicularis Henryi 5 ~ 15 parts, Radix cynanchi wilfordii 25 ~ 35 parts, Dendrobium densiflorum lindl. 10 ~ 20 parts, Rhizoma Polygonati Cirrhifolii 20 ~ 30 parts and little Radix Asparagi 15 ~ 25 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 40 ~ 45 parts, Herba hypoxis aureae 25 ~ 30 parts, Ramulus et Folium Loranthi Pentapetali 35 ~ 40 parts, Fructus Broussonetiae 30 ~ 35 parts, Herba Melastomatis Dodecandri fruit 15 ~ 20 parts, Fructus Ilicis Purpureae 10 ~ 15 parts, Semen Phaseoli lunati 20 ~ 25 parts, Herba Veronicae peregrinae 15 ~ 20 parts, grand calyx angelica root 10 ~ 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 25 ~ 30 parts, Radix Rhodiolae Yunnanensis 5 ~ 10 parts, Schisandra glaucescens Diels. 15 ~ 20 parts, large Herba Lobeliae Chinensis 25 ~ 30 parts, Radix Pedicularis Henryi 10 ~ 15 parts, Radix cynanchi wilfordii 30 ~ 35 parts, Dendrobium densiflorum lindl. 10 ~ 15 parts, Rhizoma Polygonati Cirrhifolii 20 ~ 25 parts and little Radix Asparagi 15 ~ 20 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 45 parts, Herba hypoxis aureae 26 parts, Ramulus et Folium Loranthi Pentapetali 37 parts, Fructus Broussonetiae 33 parts, Herba Melastomatis Dodecandri fruit 17 parts, Fructus Ilicis Purpureae 13 parts, Semen Phaseoli lunati 22 parts, Herba Veronicae peregrinae 16 parts, grand calyx angelica root 11 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 27 parts, Radix Rhodiolae Yunnanensis 6 parts, Schisandra glaucescens Diels. 16 parts, large Herba Lobeliae Chinensis 25 parts, Radix Pedicularis Henryi 12 parts, Radix cynanchi wilfordii 31 parts, Dendrobium densiflorum lindl. 12 parts, Rhizoma Polygonati Cirrhifolii 23 parts and little Radix Asparagi 18 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 42 parts, Herba hypoxis aureae 28 parts, Ramulus et Folium Loranthi Pentapetali 40 parts, Fructus Broussonetiae 32 parts, Herba Melastomatis Dodecandri fruit 19 parts, Fructus Ilicis Purpureae 11 parts, Semen Phaseoli lunati 24 parts, Herba Veronicae peregrinae 18 parts, grand calyx angelica root 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 29 parts, Radix Rhodiolae Yunnanensis 8 parts, Schisandra glaucescens Diels. 19 parts, large Herba Lobeliae Chinensis 28 parts, Radix Pedicularis Henryi 14 parts, Radix cynanchi wilfordii 33 parts, Dendrobium densiflorum lindl. 15 parts, Rhizoma Polygonati Cirrhifolii 21 parts and little Radix Asparagi 17 parts.

When the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae and the mixing of grand calyx angelica root, add relative to mixture 6 ~ 8 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 10 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and the temperature of cold preservation is 2 ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

When the dosage form of described Chinese medicine is glucose injection, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Beneficial effect of the present invention: Chinese traditional treatment is inseparable with western medical treatment, clinical practice also confirms, therapy of combining Chinese and Western medicine esophageal carcinoma, than simple western medical treatment, only has Chinese and western medicine closely to combine together, supplements and complements each other, and just can reach more gratifying curative effect.Chinese medicine provided by the invention overcomes the deficiency of the operation of existing simple doctor trained in Western medicine, radiotherapy or chemotherapeutic treatment esophageal carcinoma, there is the features such as side effect is little, good effect, cost are low, cure rate is high, have no drug resistance, improving the Chinese medicine in the symptom of esophageal cancer patients, sign, clinical efficacy, quality of life and survival rate with greater advantage, coordinate operation, radiotherapy, chemotherapeutic treatment by it, realize improving clinical efficacy, quality of life and cure rate.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of esophageal carcinoma, its raw medicinal material comprises: Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae, grand calyx angelica root, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix Rhodiolae Yunnanensis, Schisandra glaucescens Diels., large Herba Lobeliae Chinensis, Radix Pedicularis Henryi, Radix cynanchi wilfordii, Dendrobium densiflorum lindl., Rhizoma Polygonati Cirrhifolii and little Radix Asparagi.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Rhizoma Smilacis nipponicae: [another name] Radix et Rhizoma Smilacis Ripariae (" Herbal for Relief of Famines,), large along muscle rattan (" Zhiwu Mingshi Tukao "), Radix Schisandrae Micranthae (" Chinese medicinal herbal "), muscle stretched by the Radix Stemonae, water shakes bamboo, Herba Lycopodii, Herba Poae Sphondylodis, oxtail stretch muscle, oxtail joint, oxtail volume, water polo flower, great Ye stretch muscle, whiteback greenbrier rhizome (" Hunan medicine will ").For liliaceous plant comes into leaves the rhizome of Radix et Rhizoma Smilacis Ripariae and root.6 ~ August excavates, and cleans, dries.Hardship, flat.Relaxing muscles and tendons to promote blood circulation, removing obstruction in the collateral to relieve pain.Control waist hamstring bone pain.[extracts] " Chinese medicine voluminous dictionary "

Herba hypoxis aureae: [another name] Herba hypoxis aureae, Herba Allii bulleyani, little Jin lock prunus mume (sieb.) sieb.et zucc., imperial kidney.Hypoxidaceae Herba hypoxis aureae platymiscium Herba hypoxis aureae HypoxisaureaLour., with all herbal medicine.Xia Qiu gathers, and dries.Sweet, micro-pungent, temperature.Warming the kidney to invigorate YANG, QI invigorating.Lumbago due to renal deficiency, colicky.[extracts] " national Chinese herbal medicine compilation "

Ramulus et Folium Loranthi Pentapetali: [another name] Flos Osmanthi Fragrantis is parasitic, kapok is parasitic, sleeve paulownia is parasitic, Lignum seu Ramulus Cunninghamiae Lanceolatae parasitic (" register planted by Guangxi medicine ").For the branch and leaf of Loranthaceae plant Ramulus et Folium Loranthi Pentapetali.The whole year can adopt." register planted by Guangxi medicine ": " eliminate the phlegm, dysentery relieving, dispels the wind, and detumescence, fills blood.Control dysentery, pulmonary tuberculosis, keratitis." [extracts] " Chinese medicine voluminous dictionary "

Fructus Broussonetiae: this product is the dry mature fruit of moraceae plants Broussonetia papyrifera Broussoneriapapyrifera (L.) Vent..Gather during fruit maturation in autumn, clean, dry, the removing membranaceous Constellation calyx of canescence and impurity.Sweet, cold.Return liver, kidney channel.The kidney invigorating liver heat removing, improving eyesight, diuresis.For soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, dizzy blurred vision, the raw nebula film of order, edema distension.[extracts] " Chinese Pharmacopoeia "

Herba Melastomatis Dodecandri fruit: be the fruit of Melastomateae plants Herba Melastomatis Dodecandri.Sweet in the mouth; Warm in nature.Return kidney; Liver; Spleen channel.Kidney-replenishing blood-nourishing; Arresting bleeding and miscarriage prevention.Main essence of suffering from a deficiency of the kidney is special; Soreness of the waist and knees; Blood deficiency and yellow complexion; The deficiency of vital energy is weak; Through many; Metrorrhagia; Frequent fetal movement; The prolapse of the uterus; Proctoptosis.[extracts] " China's book on Chinese herbal medicine "

Fructus Ilicis Purpureae: [another name] Ilicis Purpureae is real, freeze blue or green tree.For the fruit of holly plant Ilicis Purpureae IlexpurpureaHassk..Sweet; Bitter; Cool.Liver; Kidney channel.Invigorating the liver and kidney; Curing rheumatism; Arresting bleeding and healing up ulcer.Main early whitening of beard and hair; Wind shows arthralgia pain; Digestive ulcerative bleeding; Hemorrhoid; Ulcer being unable to heal.[extracts] " China's book on Chinese herbal medicine "

Semen Phaseoli lunati: [another name] Yellow Emperor, a legendary ruler bean, multicolored bean.[another name] Yellow Emperor, a legendary ruler bean, multicolored bean.For the seed of leguminous plant Semen Phaseoli lunati.Sweet in the mouth; Bitter; Property is put down.Liver Channel.Enrich blood; Invigorate blood circulation; Detumescence.Main blood deficiency; Breast abdomen pain; Treating swelling and pain by traumatic injury; Edema.[extracts] " China's book on Chinese herbal medicine "

Herba Veronicae peregrinae: [another name] Herba Veronicae Peregrinae (" the lifesaving sea of bitterness "), Eight Diagrams Prunus persica f. compressa (" hospital's collection is listened "), peento grass, take that life is red, HUOXUEDAN (" detailed outline is picked up any lost article from the road ") by force, Ying Taocao (" book on Chinese herbal medicine asks former "), the public grass of ant, local lao-ya-tsao (" south of the Five Ridges gather medicinal herbs record "), Herba Veronicae peregrinae, microcephaly's grass (" medicine will is planted in Jiangsu "), calm automatic grass (" Kweiyang medicinal herbs among the people "), to invigorate blood circulation Cortex torricelliae tiliifoliae (" book on Chinese herbal medicine pushes away old "), Rhizoma seu Herba Elatostematis stewardii (" will planted by Hangzhou medicine ").For the whole herb with root (connecting insect gall to use) of goatweed fairyland grass.Between spring, summer, take advantage of before fruit entozoa is not yet overflowed and gather, herb is dried or steamed after dry, make fruit entozoa dead, kept dry." book on Chinese herbal medicine is new again ": " acrid in the mouth, cool in nature, nontoxic." " book on Chinese herbal medicine is new again ": " enters lung meridian." invigorate blood circulation, hemostasis, clearing away lung-heat, regulating liver-QI stomach.Control traumatic injury, cough sputum mixed with blood, spits blood, epistaxis, laryngopharynx swelling and pain, stomachache due to hyperactive liver-QI attacking the stomach, colic, dysmenorrhea.[extracts] " Chinese medicine voluminous dictionary "

Grand calyx angelica root: [another name] Radix Angelicae Gigatis.For the root of the grand calyx Radix Angelicae Sinensis of samphire.Acrid in the mouth; Micro-sweet; Warm in nature.Promoting blood flow to regulate menstruation; Nourishing blood for moistening dryness.Main menoxenia; Dysmenorrhea; Amenorrhea; Enemy state's void is sallow; Rheumatic ostalgia; Traumatic injury; Dryness of the intestine constipation.[extracts] " China's book on Chinese herbal medicine "

Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: [another name] YIDUOYUN (" Shaanxi Chinese herbal medicine ").For the whole herb with root of Botrychiaceae plant Herba pteridii latiusculi Cai.Spring, winter excavate, and dry or using fresh herb." Shaanxi Chinese herbal medicine ": " pained, cool." Nanchuan " conventional Chinese herbal medicine handbook ": " tonify deficiency lung moistening, relieving cough and resolving phlegm.Control cough, weak and celostomia after being ill." " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, suppressing the hyperactive liver eliminating stagnation.Control lung abscess, conjunctivitis, impairment caused by overstrain, venom, scrofula." [extracts] " Chinese medicine voluminous dictionary "

Radix Rhodiolae Yunnanensis: [another name] three seven (" Shaanxi medical herbs "), Cortex Zingiberis short top top, king butterfly (" Kunming conventional medical herbs among the people "), Hemerocallis citrina Baroni ginseng (" catalogue planted by Guizhou medicine ").For the root of crassulaceae plants Sedum yunnanense.At the beginning of spring or autumn end excavate, remove residual stem, fibrous root, clean earth, dry." Shaanxi medical herbs ": " pained, cool." heat-clearing and toxic substances removing, dissipating blood stasis stops blooding.Control laryngitis, cough, has loose bowels, dysentery, traumatic injury, wound." catalogue planted by Guizhou medicine ": " tonify deficiency, cough-relieving, heat clearing away, hemostasis.Control weak cough, knife injury is hemorrhage." [extracts] " Chinese medicine voluminous dictionary "

Schisandra glaucescens Diels.: emaciation due to emotional upset, grey Fructus Schisandrae Chinensis in [another name] powder leaf.For rattan and the root of Schisandraceae Plant Kingsoft Fructus Schisandrae Chinensis.Sweet; Bitter; Slightly warm in nature.Expelling wind and activating blood circulation; Dissipating blood stasis for subsidence of swelling.Main air pain of dampness syndrome; Impairment caused by overstrain takes off power; Goiter; Toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Large Herba Lobeliae Chinensis: [another name] Herba Strigae masuriae, Radix Glycyrrhizae.Scrophulariaceae Herba Lobeliae Chinensis platymiscium large Herba Lobeliae Chinensis Strigamasuria (Buch.-Ham.) Benth. is with all herbal medicine.Xia Qiu gathers, and chopping, dries.Sweet, light, flat.Strengthening the spleen to promote digestion, clearing away heat-damp and promoting diuresis.For infantile malnutrition, inappetence, urinary tract infection, icterohepatitis.[extracts] " national Chinese herbal medicine compilation "

Radix Pedicularis Henryi: [another name] wind catching arrow, cock flower root, mutually leaf Radix Pedicularis Henryi, phoenix tail Radix seu Herba Pedicularis.Scrophulariaceae lousewort plant south of the River Radix seu Herba Pedicularis PedicularishenryiMaxim., is used as medicine with root.Autumn excavates, and cleans and dries.Sweet, micro-hardship, temperature.Fill blood, the meridian dredging, relieving cough and asthma.For dizziness and tinnitus, palpitation and short breath, bones and muscles pain, bronchitis.[extracts] " national Chinese herbal medicine compilation "

Radix cynanchi wilfordii: [another name] Radix cynanchi wilfordii (" classifying herbal "), mountain on the other way round spade (" Tian Bao book on Chinese herbal medicine ").For the tuber of asclepiadaceae plant cynanchum auriculatum Royle.Autumn gathers, and cleans, dries." Kweiyang medicinal herbs among the people ": " sweetness and bitterness, flat, nontoxic." yin nourishing tonify deficiency, strengthening the spleen to promote digestion.Control deficient impairment caused by overstrain, dysentery, infantile malnutrition, have a stomachache glutted, leucorrhea, skin ulcer tinea.[extracts] " Chinese medicine voluminous dictionary "

Dendrobium densiflorum lindl.: [another name] Radix Et Rhizoma Rhei, Dendrobium denneanum Kerr., dendrobium.The orchid family Dendrobium densiflorum lindl. DendrobiumdensiflorumLindlexWall., is used as medicine with stem.Sweet, light, micro-salty, cold.Nourishing YIN for benefiting the kidney, promoting the production of body fluid to quench thirst.Aranea calentura, impairment of body fluid, xerostomia excessive thirst, weak after being ill.[extracts] " national Chinese herbal medicine compilation "

Rhizoma Polygonati Cirrhifolii: [another name] Radix Stephaniae Cepharanthae (" Ningxia Chinese herbal medicine handbook "), Rhizoma Bergeniae scopulosae, Streptopus simplex D. Don, Caput Gallus domesticus ginseng, Alpinia japonica (Thunb.) Miq. " Shaanxi Chinese herbal medicine "), invite alunite (Tibetan name).For the rhizome of liliaceous plant polygonatum cirrhifolium Royle.Spring, autumn take rhizome.Removing stem and leaf and fibrous root, clean, and section, dries.Gan Xin is flat.Nourishing lung-YIN, invigorating the spleen and benefiting QI, hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control chronic consumptive disease cough, dizzy, lack of appetite, seminal emission, night sweat, bleeding not during menses, puerperal, body lost, and spitted blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, and skin ulcer swells, scrofula.[extracts] " Chinese medicine voluminous dictionary "

Little Radix Asparagi: [another name] Radix Asparagi, close tooth Radix Asparagi.The little Radix Asparagi AsparagusmeiocladosLevl. of Liliaceae, is used as medicine with root.The little Radix Asparagi AsparagusmeiocladosLevl. of Liliaceae, is used as medicine with root.YIN nourishing, lung moistening, cough-relieving.Cure mainly pulmonary tuberculosis chronic cough, hectic fever is spat blood, bronchitis, edema, hernia, lactogenic.[extracts] " national Chinese herbal medicine compilation "

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 40 ~ 50 parts, Herba hypoxis aureae 20 ~ 30 parts, Ramulus et Folium Loranthi Pentapetali 30 ~ 40 parts, Fructus Broussonetiae 30 ~ 40 parts, Herba Melastomatis Dodecandri fruit 10 ~ 20 parts, Fructus Ilicis Purpureae 10 ~ 20 parts, Semen Phaseoli lunati 20 ~ 30 parts, Herba Veronicae peregrinae 15 ~ 25 parts, grand calyx angelica root 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 20 ~ 30 parts, Radix Rhodiolae Yunnanensis 5 ~ 15 parts, Schisandra glaucescens Diels. 10 ~ 20 parts, large Herba Lobeliae Chinensis 20 ~ 30 parts, Radix Pedicularis Henryi 5 ~ 15 parts, Radix cynanchi wilfordii 25 ~ 35 parts, Dendrobium densiflorum lindl. 10 ~ 20 parts, Rhizoma Polygonati Cirrhifolii 20 ~ 30 parts and little Radix Asparagi 15 ~ 25 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 40 ~ 45 parts, Herba hypoxis aureae 25 ~ 30 parts, Ramulus et Folium Loranthi Pentapetali 35 ~ 40 parts, Fructus Broussonetiae 30 ~ 35 parts, Herba Melastomatis Dodecandri fruit 15 ~ 20 parts, Fructus Ilicis Purpureae 10 ~ 15 parts, Semen Phaseoli lunati 20 ~ 25 parts, Herba Veronicae peregrinae 15 ~ 20 parts, grand calyx angelica root 10 ~ 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 25 ~ 30 parts, Radix Rhodiolae Yunnanensis 5 ~ 10 parts, Schisandra glaucescens Diels. 15 ~ 20 parts, large Herba Lobeliae Chinensis 25 ~ 30 parts, Radix Pedicularis Henryi 10 ~ 15 parts, Radix cynanchi wilfordii 30 ~ 35 parts, Dendrobium densiflorum lindl. 10 ~ 15 parts, Rhizoma Polygonati Cirrhifolii 20 ~ 25 parts and little Radix Asparagi 15 ~ 20 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 45 parts, Herba hypoxis aureae 26 parts, Ramulus et Folium Loranthi Pentapetali 37 parts, Fructus Broussonetiae 33 parts, Herba Melastomatis Dodecandri fruit 17 parts, Fructus Ilicis Purpureae 13 parts, Semen Phaseoli lunati 22 parts, Herba Veronicae peregrinae 16 parts, grand calyx angelica root 11 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 27 parts, Radix Rhodiolae Yunnanensis 6 parts, Schisandra glaucescens Diels. 16 parts, large Herba Lobeliae Chinensis 25 parts, Radix Pedicularis Henryi 12 parts, Radix cynanchi wilfordii 31 parts, Dendrobium densiflorum lindl. 12 parts, Rhizoma Polygonati Cirrhifolii 23 parts and little Radix Asparagi 18 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Smilacis nipponicae 42 parts, Herba hypoxis aureae 28 parts, Ramulus et Folium Loranthi Pentapetali 40 parts, Fructus Broussonetiae 32 parts, Herba Melastomatis Dodecandri fruit 19 parts, Fructus Ilicis Purpureae 11 parts, Semen Phaseoli lunati 24 parts, Herba Veronicae peregrinae 18 parts, grand calyx angelica root 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 29 parts, Radix Rhodiolae Yunnanensis 8 parts, Schisandra glaucescens Diels. 19 parts, large Herba Lobeliae Chinensis 28 parts, Radix Pedicularis Henryi 14 parts, Radix cynanchi wilfordii 33 parts, Dendrobium densiflorum lindl. 15 parts, Rhizoma Polygonati Cirrhifolii 21 parts and little Radix Asparagi 17 parts.

When the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae and the mixing of grand calyx angelica root, add relative to mixture 6 ~ 8 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 10 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and the temperature of cold preservation is 2 ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

When the dosage form of described Chinese medicine is glucose injection, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: oral solutions

Get Rhizoma Smilacis nipponicae 450g, Herba hypoxis aureae 260g, Ramulus et Folium Loranthi Pentapetali 370g, Fructus Broussonetiae 330g, Herba Melastomatis Dodecandri fruit 170g, Fructus Ilicis Purpureae 130g, Semen Phaseoli lunati 220g, Herba Veronicae peregrinae 160g, grand calyx angelica root 110g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 270g, Radix Rhodiolae Yunnanensis 60g, Schisandra glaucescens Diels. 160g, large Herba Lobeliae Chinensis 250g, Radix Pedicularis Henryi 120g, Radix cynanchi wilfordii 310g, Dendrobium densiflorum lindl. 120g, Rhizoma Polygonati Cirrhifolii 230g and little Radix Asparagi 180g.

Its preparation method comprises the following steps:

When the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae and the mixing of grand calyx angelica root, add relative to mixture 7 times amount determining alcohol be 60% alcohol reflux 4 times, each 2 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 8 times of water gagings, boils 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 40 hours, and the temperature of cold preservation is 4 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.24; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 35 minutes, and temperature is 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Embodiment 2: glucose injection

Get Rhizoma Smilacis nipponicae 420g, Herba hypoxis aureae 280g, Ramulus et Folium Loranthi Pentapetali 400g, Fructus Broussonetiae 320g, Herba Melastomatis Dodecandri fruit 190g, Fructus Ilicis Purpureae 110g, Semen Phaseoli lunati 240g, Herba Veronicae peregrinae 180g, grand calyx angelica root 120g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 290g, Radix Rhodiolae Yunnanensis 80g, Schisandra glaucescens Diels. 190g, large Herba Lobeliae Chinensis 280g, Radix Pedicularis Henryi 140g, Radix cynanchi wilfordii 330g, Dendrobium densiflorum lindl. 150g, Rhizoma Polygonati Cirrhifolii 210g and little Radix Asparagi 170g.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.5 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 minutes at this, the micron particles of acquisition 0.1 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 20g that second step obtains, adds propylene glycol 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 50 minutes; Decarbonization filtering; With 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Toxicity test:

Acute toxicity testing: application mice 80, male and female half and half, body weight 24 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the extract oral liquor prepared by embodiments of the invention 1 is dissolved in water, (concentration is 7.30g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.5 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage oral solutions LD50>36.5 crude drug/kg of the present invention, every day, maximum dosage-feeding was 73.0 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 27g) oral administration gavage Chinese medicine of the present invention is 682 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 oral solutions of the present invention presses 13.12,19.03 and 37.45g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: esophageal carcinoma case 104 example is included in this research altogether in, all derives from the court's in February, 2010 ~ outpatient service in January, 2013 and inpatient.MethodsThe cases enrolled is divided into treatment group and matched group at random, and extract oral liquor prepared by the oral embodiment of the present invention 1 for the treatment of group also coordinates radiotherapy, totally 52 examples, man 28 example, female 24 example, 43 ~ 72 years old age, the course of disease 6 months ~ 6 year half, focus is positioned at epimere 22 example, stage casing 17 example, hypomere 13 example.Matched group adopts radiotherapy merely, totally 52 examples, man 27 example, female 25 example, 45 ~ 71 years old age, and the course of disease 5 months ~ 6 years, focus is positioned at epimere 23 example, stage casing 18 example, hypomere 11 example.Two groups of cases are all made a definite diagnosis through gastroscope and pathologic finding.Treatment group scale cancer 36 example, adenocarcinoma 16 example.Matched group scale cancer 38 example, adenocarcinoma 14 example.Two groups of clinical characters are similar, difference not statistically significant (P>0105).All cases are radiotherapy contraindication except relevant inspection all.

Diagnostic criteria: (1) symptom: the early stage esophageal carcinoma has ingest food choking feeling, acupuncture sample pain or foreign body in esophagus sense after breastbone, classical symptom Progressive symmetric erythrokeratodermia dysphagia.(2) early stage Absence of physical signs, late period becomes thin, dewater.(3) esophagus gulps down the contrast examination of barium x-ray: early stage x-ray sign has: 1. mucosa gauffer increase thick, tortuous or dotted line shape interrupt or esophagus edge scared; 2. little filling defect, or more flat or as polypoid; 3. aphtha niche; 4. limitation tube wall is sent out deadlock or is had barium agent to be detained.Middle and advanced stage esophagus x-ray barium meal examination can show barium agent and stagnate at cancerous protuberance point, and pathological changes section barium stream is carefully narrow; Esophageal wall is stiff, wriggle weakness, and mucosa stricture of vagina is thicker and disorderly, and edge is crude; Esophageal lumen is narrow and irregular, blocks epimere and slightly expands, and can have the changes such as ulcer niche shadow and filling defect.(4) esophageal cast-off cell inspection: early stage positive rate can reach 90%-95%.(5) esophagoscopy: visible luminal stenosis, mucosal damage.(6) fiber esophagogastroscopy: the pathological changes situation directly observing Esophageal Mucosa, can be clarified a diagnosis by brush inspection and biopsy, the diagnosis rate for middle and advanced stage esophageal carcinoma can reach 100%.When early lesion is difficult to difference under scope, available 1%-2% toluidine blue or the capable Esophageal Mucosa dyeing of 3%-5%Lugol iodine solution.The former does not dye at normal epithelial, and by blue for tumor tissues dye; The latter will make normal esophageal squamous epithelial cancer dye brownish black, and tumor tissues is not vivid by iodine staining.

Therapeutic Method:

Two groups all adopt linear accelerator 6MV or 15MVX line radiotherapy, and conventional three wild irradiations, each 200cGy, irradiates 5 times weekly, weekly dose 1000cGy, 7 weeks totally.Treatment group patient starts at radiotherapy first day the extract oral liquor adding the embodiment of the present invention 1 preparation, every day 3 times, each 10ml.

Matched group adopts merely radiotherapy 7 weeks.

Outcome measure: judge according to esophageal cancer medicine treatment criterion of therapeutical effect in " combination of Chinese and Western medicine clinical tumor internal medicine ".1. complete incidence graph (CR): x-ray esophageal barium meal x-ray levies disappearance, basic recovery is normal, and the sign that health check-up exists without tumor, more than 1 month; 2. partial rcsponse (PR): x-ray esophagus meal radiography and health check-up can measure tumor regression more than 50%, occur without new focus, be continued above 1 month, 3. minor effect (MR): x-ray esophageal barium meal radiography and health check-up can measure tumor regression more than 25%, but less than 50%, occur without new focus, be continued above 1 month; 4. stable (SD): x-ray esophageal barium meal radiography and health check-up can measure tumor regression less than 25%, increase and are no more than 25%, be continued above 1 month; 5. (PD) is worsened: x-ray esophageal barium meal radiography and health check-up can be measured tumor and be increased more than 25%, and new focus can be had to occur.

Evaluate life quality with or without improving, Main Basis Karnofsky standards of grading.

Focal pathological changes therapeutic evaluation result, the results are shown in Table 1.

Table 1 cancer remission rate (WHO)

Table 1 can be found out, the total effective rate for the treatment of group is obviously greater than the total effective rate of matched group, and treatment group is better than matched group on therapeutic effect.

Treatment Patients Before And After overall health of patients, hemogram and immunologic function situation, the results are shown in Table 2.

Table 2 treatment group is marked with overall health of patients before and after treatment of control group (Ka Shi marks), hemogram compares with immunologic function situation

Note: ^*p<0.05 is compared before and after treatment, ^△p<0.05 is compared with after treatment of control group after treatment group treatment.

As known from Table 2, after treatment of control group, WBC, T cell all significantly decline; And Ka Shi scoring obviously raises after treatment group treatment, and Hb, WBC content is all significantly higher than matched group.

Life cycle, distribution was compared, in table 3.

Table 3 liang group distribution situation life cycle (%)

Group	Number of cases	1 year	2 years
				Treatment group	52	49(94.2％)	36(69.2％)
Matched group	52	33(63.5％)	25(48.1％)

As shown in table 3, within 1 year, survival rate treatment group is 94.2%, is better than 63.5% (P<0.01) of matched group, and within 2 years, survival rate treatment group is 69.2%, is obviously better than matched group 48.1% (P<0.01).

Meanwhile, follow up a case by regular visits to in periodic review process in tracking, observe: in treatment group 16CR patient, without recurrence and transfer, in 23 routine PR patients, aggravation 1 example, total relapse rate is 1.9% (1/52); In the routine CR patient of matched group 9, recur 2 people, in 15 routine PR patients, aggravation or transfer 7 example, total relapse rate 17.3% (9/52).

Concrete case: Xue, women, 52 years old.Because of Progressive symmetric erythrokeratodermia dysphagia, water paddy not under, retrosternal pain companion was admitted to hospital more than emaciated physique April.Show on esophagus through gastroscopy, stage casing cancer, pathocytology inspection is diagnosed as esophageal squamous cell carcinoma.Barium meal examination shows that length of lesion is about about 12cm, and narrow in various degree of uterine cavity, tube wall is stiff, diseased region mucosal discontinuities, and barium agent is by being obstructed.Taking the extract oral liquor prepared by the embodiment of the present invention 1 while radiotherapy, every day 3 times, each 10ml, 30 days is a course for the treatment of, and after taking 1 course for the treatment of, swallow comparatively unobstructed, can enter half liquid food, appetite increases, and retrosternal pain obviously alleviates.After radiotherapy terminates, conditions of patients complete incidence graph, swallow normal, diet also obviously improves.Be interrupted after treatment of taking medicine after radiotherapy, follow up a case by regular visits to 2 years, swallow normal, in high spirits, diet is as ordinary person, and body weight increases 6kg.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat the Chinese medicine of esophageal carcinoma for one kind, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Smilacis nipponicae 40 ~ 50 parts, Herba hypoxis aureae 20 ~ 30 parts, Ramulus et Folium Loranthi Pentapetali 30 ~ 40 parts, Fructus Broussonetiae 30 ~ 40 parts, Herba Melastomatis Dodecandri fruit 10 ~ 20 parts, Fructus Ilicis Purpureae 10 ~ 20 parts, Semen Phaseoli lunati 20 ~ 30 parts, Herba Veronicae peregrinae 15 ~ 25 parts, grand calyx angelica root 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 20 ~ 30 parts, Radix Rhodiolae Yunnanensis 5 ~ 15 parts, Schisandra glaucescens Diels. 10 ~ 20 parts, large Herba Lobeliae Chinensis 20 ~ 30 parts, Radix Pedicularis Henryi 5 ~ 15 parts, Radix cynanchi wilfordii 25 ~ 35 parts, Dendrobium densiflorum lindl. 10 ~ 20 parts, Rhizoma Polygonati Cirrhifolii 20 ~ 30 parts and little Radix Asparagi 15 ~ 25 parts.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Smilacis nipponicae 40 ~ 45 parts, Herba hypoxis aureae 25 ~ 30 parts, Ramulus et Folium Loranthi Pentapetali 35 ~ 40 parts, Fructus Broussonetiae 30 ~ 35 parts, Herba Melastomatis Dodecandri fruit 15 ~ 20 parts, Fructus Ilicis Purpureae 10 ~ 15 parts, Semen Phaseoli lunati 20 ~ 25 parts, Herba Veronicae peregrinae 15 ~ 20 parts, grand calyx angelica root 10 ~ 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 25 ~ 30 parts, Radix Rhodiolae Yunnanensis 5 ~ 10 parts, Schisandra glaucescens Diels. 15 ~ 20 parts, large Herba Lobeliae Chinensis 25 ~ 30 parts, Radix Pedicularis Henryi 10 ~ 15 parts, Radix cynanchi wilfordii 30 ~ 35 parts, Dendrobium densiflorum lindl. 10 ~ 15 parts, Rhizoma Polygonati Cirrhifolii 20 ~ 25 parts and little Radix Asparagi 15 ~ 20 parts.

3. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Smilacis nipponicae 45 parts, Herba hypoxis aureae 26 parts, Ramulus et Folium Loranthi Pentapetali 37 parts, Fructus Broussonetiae 33 parts, Herba Melastomatis Dodecandri fruit 17 parts, Fructus Ilicis Purpureae 13 parts, Semen Phaseoli lunati 22 parts, Herba Veronicae peregrinae 16 parts, grand calyx angelica root 11 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 27 parts, Radix Rhodiolae Yunnanensis 6 parts, Schisandra glaucescens Diels. 16 parts, large Herba Lobeliae Chinensis 25 parts, Radix Pedicularis Henryi 12 parts, Radix cynanchi wilfordii 31 parts, Dendrobium densiflorum lindl. 12 parts, Rhizoma Polygonati Cirrhifolii 23 parts and little Radix Asparagi 18 parts.

4. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Smilacis nipponicae 42 parts, Herba hypoxis aureae 28 parts, Ramulus et Folium Loranthi Pentapetali 40 parts, Fructus Broussonetiae 32 parts, Herba Melastomatis Dodecandri fruit 19 parts, Fructus Ilicis Purpureae 11 parts, Semen Phaseoli lunati 24 parts, Herba Veronicae peregrinae 18 parts, grand calyx angelica root 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 29 parts, Radix Rhodiolae Yunnanensis 8 parts, Schisandra glaucescens Diels. 19 parts, large Herba Lobeliae Chinensis 28 parts, Radix Pedicularis Henryi 14 parts, Radix cynanchi wilfordii 33 parts, Dendrobium densiflorum lindl. 15 parts, Rhizoma Polygonati Cirrhifolii 21 parts and little Radix Asparagi 17 parts.

5. the Chinese medicine as described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:

The first step, by Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae and the mixing of grand calyx angelica root, add relative to mixture 6 ~ 8 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 10 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and the temperature of cold preservation is 2 ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

6. the Chinese medicine as described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

7. a preparation method for Chinese medicine described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:

The first step, by Rhizoma Smilacis nipponicae, Herba hypoxis aureae, Ramulus et Folium Loranthi Pentapetali, Fructus Broussonetiae, Herba Melastomatis Dodecandri fruit, Fructus Ilicis Purpureae, Semen Phaseoli lunati, Herba Veronicae peregrinae and the mixing of grand calyx angelica root, add relative to mixture 6 ~ 8 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 10 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and the temperature of cold preservation is 2 ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

8. a preparation method for Chinese medicine described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is glucose injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.