CN104800429A - Ointment for external use for treating acne and preparation method of ointment - Google Patents

Abstract

The invention relates to ointment for external use for treating acne. The ointment is prepared by the following raw materials in parts by weight: 17 parts of urtica dioica, 15 parts of calamint, 9 parts of scutellaria indica, 19 parts of blumea, 19 parts of mottle leaves, 13 parts of ghostplant wormwood herb, 13 parts of scutellaria baicalensis, 5 parts of notopterygium root and 13 parts of egg white. The preparation method comprises the following steps: a, crushing and uniformly mixing urtica dioica, calamint, scutellaria indica, blumea, mottle leaves, ghostplant wormwood herb and scutellaria baicalensis to obtain a mixture, adding 70% ethanol according to a material liquid ratio of 1: 9, carrying out the reflux extraction for 3 times, the refluxing extraction time is 1 to 2 hours each time, and merging the reflux solution; concentrating the mixed solution to obtain extract with relative density of 1.25 to 1.30 (30 DEG C); b, crushing the notopterygium root into 500-mesh powder; c, uniformly mixing the egg white, the powder in the step b and the extract in the step a. All herbs are compatible, the synergistic effect is remarkable, functions for clearing away the internal heat, detoxifying, removing swelling, eliminating the stagnant blood, promoting the blood circulation and improving the skin immunity can be realized, and the curative effect for the acne is remarkable.

Description

External-applied ointment of a kind of Acne treatment and preparation method thereof

Technical field

The invention belongs to Chinese medicine external medicine, particularly relate to external-applied ointment of a kind of Acne treatment and preparation method thereof.

Background technology

Acne, is commonly called as comedo, skin sore, and the traditional Chinese medical science is referred to as acne vulgaris, whelk ancient times, is that one betides pilosebaceous chronic dermatosis.Be more common in the position that the sebaceous gland such as Head And Face, cervical region, shirtfront, back are abundant.Clinical with Whiteheads, blackhead, inflamed papules, pustule, tuberosity, cyst etc. for main manifestations.Except child, about there is the people of 80% ~ 90% to suffer from primary disease in crowd or once suffered from primary disease (comprising mild).Acne occurs in pilosebaceous chronic dermatosis, and this pathogenetic factor is varied, but the most direct factor is exactly clogging of pores.

Comedo is the common skin diseases of hebetic child, is also than being easier to morbidity, if process bad it will leave pox print pox scar.Modern medicine study is thought, generation and the dietary structure of acne are unreasonable, psychentonia, trace element deficiency, the factors such as heredity are relevant, principal element is that Development in Puberty is ripe, Serum Testosterone Levels increases stimulates sebum secretion to increase, and is difficult to discharge and be gathered in hair follicle, produces papular infringement, sebaceous gland excretion and disturbance of blood circulation are bred to again the infection of antibacterial and are created condition, and secondary hair follicle and perifollicolar are inflamed abscess and tuberosity.TCM investigation is thought, the morbidity root of acne and deficiency of kidney yin, and the negative and positive (endocrine) of kidney are lacked of proper care relevant, cause hyperactivity of the ministerial fire, stasis skin, or disharmony of Chong and Conception Channels, lung stomach heat in blood stasis smokes women's head-ornaments and causes.

Summary of the invention

The object of this invention is to provide external-applied ointment of a kind of Acne treatment and preparation method thereof.

The external-applied ointment of Acne treatment of the present invention, is made up of the raw material of following parts by weight: stinging nettle 16 ~ 18 parts, Herba Clinopodii Polycephali 14 ~ 16 parts, Herba Scutellariae indicae 8 ~ 10 parts, Herba Blumeae Lacerae 18 ~ 20 parts, Herba Cissi Javanae 18 ~ 20 parts, Herba artemisiae lactiflorae 12 ~ 14 parts, Radix Scutellariae 12 ~ 14 parts, Rhizoma Et Radix Notopterygii 4 ~ 6 parts, Ovum Gallus domesticus album 12 ~ 14 parts.

As optimization, the external-applied ointment of this Acne treatment, is made up of the raw material of following parts by weight: stinging nettle 17 parts, Herba Clinopodii Polycephali 15 parts, Herba Scutellariae indicae 9 parts, Herba Blumeae Lacerae 19 parts, Herba Cissi Javanae 19 parts, Herba artemisiae lactiflorae 13 parts, Radix Scutellariae 13 parts, Rhizoma Et Radix Notopterygii 5 parts, Ovum Gallus domesticus album 13 parts.

Prepare the method for this Acne treatment external-applied ointment, comprise the following steps:

A, by the stinging nettle of described parts by weight, Herba Clinopodii Polycephali, Herba Scutellariae indicae, Herba Blumeae Lacerae, Herba Cissi Javanae, Herba artemisiae lactiflorae, Radix Scutellariae pulverize after mix homogeneously, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 1 ~ 2 hour, merge backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.30 (30 DEG C);

B, the Rhizoma Et Radix Notopterygii of described parts by weight is ground into 500 object powder;

C, by the Ovum Gallus domesticus album of described parts by weight, and the powder in step b and the extractum in step a, mix homogeneously.

In Acne treatment external-applied ointment of the present invention, stinging nettle expelling wind and removing dampness, promoting blood circulation and stopping pain is antipruritic; Cure mainly rheumatic numbness, arthralgia, impairment caused by overstrain pain, colic, edema, venom, skin pruritus, infantile convulsion milk regurgitation, women's puerperal asthenia.Herba Clinopodii Polycephali wind and heat dispersing, removing toxic substances dysentery relieving, hemostasis; For flu, heatstroke, dysentery, hepatitis; Furuncle swelling toxin, skin pruritus, traumatic hemorrhage are controlled in external.Herba Scutellariae indicae dispels the wind, and invigorates blood circulation, removing toxic substances, pain relieving; Control traumatic injury, spit blood, hemoptysis, carbuncle, furunculosis, acute throat trouble, toothache.Herba Blumeae Lacerae heat-clearing and toxic substances removing, reducing swelling and alleviating pain; For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia; Carbuncle pyogenic infections from tumour or sore is controlled in external, skin pruritus.Herba Cissi Javanae dispelling wind detoxifies, detumescence dissipating blood stasis, reunion of bone; Control urticaria, eczema, allergic dermatitis, the fracture injury of tendon and muscle, osteopatia sprain, rheumatic numbness.Radix Scutellariae removing the relative excess fire, except damp and hot, hemostasis, antiabortive; Control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.Rhizoma Et Radix Notopterygii falls apart exterior cold; Wind-damp dispelling; Profit joint; Pain relieving; Main affection of exogenous wind-cold; Have a headache lossless; Edema due to wind pathogen edema; Sore swollen toxin; For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.Herba artemisiae lactiflorae is regulated the flow of vital energy, and invigorates blood circulation, regulating menstruation, dampness removing, removing toxic substances, detumescence; For menoxenia, amenorrhea, chronic hepatitis, liver cirrhosis, oedema due to nephritis, leucorrhea, urticaria, abdominal distention, hernia; Traumatic injury is controlled in external, traumatic hemorrhage, burn and scald, skin infection, eczema.Ovum Gallus domesticus album not only can make whiteness of skin, and skin can be made delicate, also has the effect of heat-clearing and toxic substances removing and enhancing skin immune function controlling.

All medicine compatibilities above, as the external-applied ointment of Acne treatment, synergy is very outstanding, and jointly play heat-clearing and toxic substances removing, effect of skin immunization power is invigorated blood circulation, improved in detumescence dissipating blood stasis, detumescence, the therapeutic effect for acne is obvious, and total effective rate reaches 91.2%.

Experimental summary is reported as follows: physical data: patients with acne 182 example, is divided into two groups immediately, often organizes 91 examples.Treatment group man 45 example, female 46 example, 13 ~ 34 years old age, average (19.0 ± 2.9) year, the course of disease 1 month ~ 8 years, average (3.2 ± 1.9) year.Matched group man 47 example, female 44 example, 12 ~ 33 years old age, average (20.3 ± 2.8) year, the course of disease 2 months ~ 9 years, average (3.1 ± 2.0) year.Two groups in sex, the age, roughly similar in the course of disease, through statistical procedures, difference there are no significant meaning (P > 0.05).

Diagnostic criteria: the diagnostic criteria of acne in " the Chinese medical disease Standardization of diagnosis and curative effect " issued for 1994 according to State Administration of Traditional Chinese Medicine: 1) from the beginning of the red papules presenting small rice grain size at follicular orifice, purulent core can be developed into, after this can form scleroma sample white acne or blackhead, several cases can form scleroma property cyst; 2) be mainly in the face of adolescence men and women, chest and back, often have seborrhea; 3) how by eating and drinking without temperance, surfeit delicious food savoury, or sense exopathogen etc. brings out; 4) women many with menstruationuncomfortable; 5) course of disease repeatedly, in chronic process, can be formed cicatrix.

Exclusion standard: 1) age person more than 35 years old; 2) pregnancy women; 3) occupational acne; 4) severe cardiac, liver, renal damage and disease of hematopoietic system person is had.

Therapeutic Method: treatment group, adopt the external-applied ointment of Acne treatment in the embodiment of the present invention 1, being coated onto affected part, every day 3 times, one month is a course for the treatment of.The oral cimetidine tablet (specification 0.2g) of matched group, every day 3 times, each 1 one month is a course for the treatment of.

Criterion of therapeutical effect: according to the efficacy assessment standard of acne in " Chinese medical disease Standardization of diagnosis and curative effect ", cure: skin lesion disappears, subjective symptoms disappears; Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%; Do not heal: skin lesion and symptom unchanged or disappear less than 30%.Two groups of case efficacy results refer to table 1.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1, a, by stinging nettle 170 grams, Herba Clinopodii Polycephali 150 grams, Herba Scutellariae indicae 90 grams, Herba Blumeae Lacerae 190 grams, Herba Cissi Javanae 190 grams, Herba artemisiae lactiflorae 130 grams, Radix Scutellariae 130 grams pulverize after mix homogeneously, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 1 ~ 2 hour, merges backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.30 (30 DEG C); B, Rhizoma Et Radix Notopterygii 50 grams is ground into 500 object powder; C, by Ovum Gallus domesticus album 130 grams, and the powder in step b and the extractum in step a, mix homogeneously.

Embodiment 2, a, by stinging nettle 160 grams, Herba Clinopodii Polycephali 140 grams, Herba Scutellariae indicae 80 grams, Herba Blumeae Lacerae 180 grams, Herba Cissi Javanae 180 grams, Herba artemisiae lactiflorae 120 grams, Radix Scutellariae 120 grams pulverize after mix homogeneously, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 1 ~ 2 hour, merges backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.30 (30 DEG C); B, Rhizoma Et Radix Notopterygii 40 grams is ground into 500 object powder; C, by Ovum Gallus domesticus album 120 grams, and the powder in step b and the extractum in step a, mix homogeneously.

Embodiment 3, a, by stinging nettle 180 grams, Herba Clinopodii Polycephali 160 grams, Herba Scutellariae indicae 100 grams, Herba Blumeae Lacerae 200 grams, Herba Cissi Javanae 200 grams, Herba artemisiae lactiflorae 140 grams, Radix Scutellariae 140 grams pulverize after mix homogeneously, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 1 ~ 2 hour, merges backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.30 (30 DEG C); B, Rhizoma Et Radix Notopterygii 60 grams is ground into 500 object powder; C, by Ovum Gallus domesticus album 140 grams, and the powder in step b and the extractum in step a, mix homogeneously.

Claims (3)

1. the external-applied ointment of an Acne treatment; It is characterized in that being made up of the raw material of following parts by weight: stinging nettle 16 ~ 18 parts, Herba Clinopodii Polycephali 14 ~ 16 parts, Herba Scutellariae indicae 8 ~ 10 parts, Herba Blumeae Lacerae 18 ~ 20 parts, Herba Cissi Javanae 18 ~ 20 parts, Herba artemisiae lactiflorae 12 ~ 14 parts, Radix Scutellariae 12 ~ 14 parts, Rhizoma Et Radix Notopterygii 4 ~ 6 parts, Ovum Gallus domesticus album 12 ~ 14 parts.

2. want the external-applied ointment of Acne treatment described in 1 according to right, it is characterized in that being made up of the raw material of following parts by weight: stinging nettle 17 parts, Herba Clinopodii Polycephali 15 parts, Herba Scutellariae indicae 9 parts, Herba Blumeae Lacerae 19 parts, Herba Cissi Javanae 19 parts, Herba artemisiae lactiflorae 13 parts, Radix Scutellariae 13 parts, Rhizoma Et Radix Notopterygii 5 parts, Ovum Gallus domesticus album 13 parts.

3. prepare a method for Acne treatment external-applied ointment described in claim 1, it is characterized in that comprising the following steps:

A, by stating the stinging nettle of parts by weight, Herba Clinopodii Polycephali, Herba Scutellariae indicae, Herba Blumeae Lacerae, Herba Cissi Javanae, Herba artemisiae lactiflorae, Radix Scutellariae pulverize after mix homogeneously, by solid-liquid ratio 1:9, add 70% ethanol, reflux, extract, 3 times, each 1 ~ 2 hour, merge backflow; Be condensed into the extractum that relative density is 1.25 ~ 1.30 (30 DEG C);

B, the Rhizoma Et Radix Notopterygii of described parts by weight is ground into 500 object powder;

C, by the Ovum Gallus domesticus album of described parts by weight, and the powder in step b and the extractum in step a, mix homogeneously.