CN104800368A - Medicinal composition for treating bronchiectasis, and formation method thereof - Google Patents
Medicinal composition for treating bronchiectasis, and formation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal composition for treating bronchiectasis, and a formation method thereof. The medicinal composition comprises, by weight, 5-20 parts of Radix Platycodonis, 5-20 parts of Radix Scutellariae, 10-30 parts of Herba Houttuyniae, 5-18 parts of apricot kernel, 8-25 parts of Cacumen Platycladi and 5-16 parts of honey-fried licorice root. The medicinal composition has the advantages of wide medicine sources, low cost, use convenience, no allergy, no side effects, and simultaneous treatment of principal and subordinate symptoms, has the efficacies of heat clearing, lung moistening, phlegm eliminating, pus expelling, qi rectifying and blood astringing, can substantially improve the western medicine symptoms (coughs, expectoration and hemoptysis) and traditional Chinese medicine symptoms (coughs, rough breathing, viscous and yellow phlegm, bloody phlegm, hemoptysis, fever thirst, stuffy feeling in chest, constipation, red tongue, yellow fur and slippery and rapid pulse) of phlegm-heat obstructing lung type bronchiectasis, can maintain or improve functions of the lung, can reduce acute attack, and can reduce the use amount of antibiotics in order to improve the living quality of patients.
Description
Technical field
The present invention relates to field of medicine preparations, particularly one is used for the treatment of bronchiectasic pharmaceutical composition and forming method thereof.
Background technology
Bronchiectasis is that China to continue after COPD (chronic obstructive pulmonary diseases, chronic obstructive pulmonary disease), asthma the 3rd common chronic airflow restricted gender disease.Bronchiectasis: also claim bronchiectasis, be called for short an expansion, abnormal for feature with local bronchus irreversibility anatomical structure, due to bronchus and around lung tissue chronic suppurative inflammation and fibrosis, the muscle of bronchial wall and Elastic tissue are destroyed, causes bronchus be out of shape and expand lastingly.Clinical manifestation is chronic cough, coughs a large amount of purulent sputum, is interrupted and repeatedly spits blood, and most the pulmonary functions expanding patient are that Progressive symmetric erythrokeratodermia declines, and have a strong impact on the quality of life of patient.Expansion is chronic disease year in year out, belongs to the traditional Chinese medical science " cough ", " spitting of blood ", " lung abscess " category.Expand patient many genus deficiency in origin and excess in superficiality, expectorant, heat, the stasis of blood for mark, the deficiency of vital energy, the deficiency of YIN be this, simulataneous insufficiency and excessive, mark is real is main, doublely sees deficiency in origin, and syndrome Cluster Typing prompting phlegm-heat obstructing lung type or its accompanied symptoms will account for 85.3% of all expansion cases.
Phlegm-heat obstructing in the lung: TCM-related Terms, refers to combination of phlegm and heat, stops up and closes in lung, thirsty with fever of the body, coughs rough, spits yellow thick, uncomfortable in chest vexed, or coughs vomiting bloody pus and to smell as of rotten fish expectorant, and red tongue with yellowish and greasy fur, slippery and rapid pulse etc. are the syndrome of common disease.
Expand long-term prognosis poor, the quality of life of patient is impaired, can bring heavy social economical burden, thus explores and develop treatment prop up expansion effective ways urgent and necessary.Prop up the therapeutic purposes expanded to comprise: determine and treat the potential cause of disease to stop progression of disease, maintain or improve pulmonary function, reduce acute exacerbation number of times, improve the quality of life of patient.
The mainly physics expectoration of existing western medical treatment means, medicine are reduced phlegm (ambroxol etc.), infection (antibiotics such as cephalo-type, quinolones), but antibiotics is mostly expensive, and the long-term antibiotics that uses easily causes drug resistance and dysbacteriosis, antibiotics side reaction is comparatively large, has irritated possibility.
Existing Chinese traditional treatment means are mainly heat clearing away, eliminate the phlegm, cough-relieving, blood stasis dispelling, hold back blood, promote the production of body fluid, classical proved recipe has " weijing decoction ", " clearing heat in the lung phlegm-reducing soup " etc., the inconvenience but Rhizoma Phragmitis is drawn materials (pharmacy is without selling, wanting fresh goods), and decoct comparatively inconvenience (consumption large, should first boil), raw material Semen Persicae in addition in weijing decoction has the effect of invigorating blood circulation, and should not use when an expansion is spat blood.
Summary of the invention
The problem that the present invention solves is that western medical treatment bronchiectasis is expensive, and side reaction is comparatively large, and the bronchiectasic formula of Chinese traditional treatment is drawn materials inconvenient problem.
For solving the problem, the invention provides one and being used for the treatment of bronchiectasic pharmaceutical composition, the raw material primarily of following weight parts forms:
Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts.
Optionally, in described pharmaceutical composition, described Radix Platycodonis 5 ~ 12 parts, Radix Scutellariae 5 ~ 12 parts, Herba Houttuyniae 10 ~ 25 parts, 5 ~ 10 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 18 parts, Radix Glycyrrhizae Preparata 5 ~ 10 parts.
Optionally, in described pharmaceutical composition, Radix Platycodonis is 10 ~ 20 parts, Radix Scutellariae is 10 ~ 20 parts, Herba Houttuyniae is 20 ~ 30 parts, Semen Armeniacae Amarum is 10 ~ 15 parts, Cacumen Platycladi 8 ~ 20 parts, Radix Glycyrrhizae Preparata are 8 ~ 12 parts.
Optionally, described pharmaceutical composition is the medicine of decoction, pill, powder, unguentum, sublimed preparation, atomized inhalation, granule, tablet or syrup form or medicament or preparation.
Present invention also offers a kind of pharmaceutical composition being used for the treatment of bronchiectasic decoction form, the raw material primarily of following weight parts forms:
Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts and 50 ~ 100 parts, water.
The embodiment of the present invention additionally provides a kind of formation method of pharmaceutical composition of decoction form, comprising:
There is provided the raw material of Chinese medicine of following weight parts: Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts; Described raw material of Chinese medicine is placed in and decocts in container, the pure water added in decoction container; Described raw material of Chinese medicine is decocted; Filtering medicinal residues, obtain decoction.
Optionally, before raw material of Chinese medicine is decocted, raw material of Chinese medicine is soaked 20 ~ 40 minutes in pure water.
Optionally, the pure water added described in exceedes 2 ~ 3 centimetres of powder.
Optionally, the pure water weight portion added described in is 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing.
Optionally, it is characterized in that, described decoction process comprises head and decocts and secondary decoction, is decocting the pure water adding the first weight portion in container, carries out head and decocts, filtering raw material, obtain head and decoct decoction; Raw material after decocting for correct time adds the pure water of the second weight portion, carries out secondary decoction, filtering medicinal residues, obtains secondary decoction; By head time decoction and the mixing of secondary decoction, form decoction.
Optionally, the total weight parts of the pure water of the first weight portion and the pure water of the second weight portion is 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing, and the weight portion that the weight portion of the pure water of the first weight portion is the pure water of the 60% ~ 70%, second weight portion of the total weight parts of pure water is 30% ~ 40%. of the total weight parts of pure water
Optionally, the process of described decoction, for first boiling with high heat, then decocts with slow fire.
Optionally, the temperature of described intense fire is 180 ~ 190 degrees Celsius, and slow fire is 100 ~ 150 degrees Celsius, and the time of decoction is 15 ~ 25 minutes.
Present invention also offers a kind of formation method of pharmaceutical composition of pill, comprise: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, then with the pellet preparation that water, honey, batter, rice paste, medicine juice or Cera Flava mixing become to differ in size.
Present invention also offers a kind of formation method of pharmaceutical composition of powder form, comprising: by the raw material pulverize of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, sieve.
Present invention also offers a kind of formation method of pharmaceutical composition of ointment, comprise: being added water by the raw material of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts decocts, elimination dregs, then the soft extract adding that crystal sugar or Mel are boiled into stiff.
Present invention also offers a kind of formation method of pharmaceutical composition of sublimed preparation form, comprise: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, be refined into the preparation of pellet, ingot shape.
Present invention also offers a kind of formation method of pharmaceutical composition of tablet form, comprise: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, or make fluid extract, then add excipient and be pressed into Formulation.
Present invention also offers a kind of formation method of pharmaceutical composition of granular form, comprising: refer to the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts or thick paste; Put in container with adjuvant and mix homogeneously, add the soft material that wetting agent is made; Pass through l4 ~ 22 eye mesh screen with fashion of extrusion again, make uniform granule.
Present invention also offers a kind of formation method of pharmaceutical composition of syrup form, comprise: sucrose is added a certain amount of boil by Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts of drug solutions formed, continue heating and make sucrose dissolved, filtered while hot, makes syrup.
Present invention also offers a kind of formation method of pharmaceutical composition of atomized inhalation form, comprise: distill after the raw material adding distil water of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, collect distillate, leaching concentration of liquid medicine, to cold, adds ethanol in proper amount, abundant stirring, precipitation is got supernatant and is reclaimed ethanol to without alcohol taste, reconcentration, cool centrifugal after add distilled water and make Neulized inhalation liquid.
Compared with prior art, technical scheme of the present invention has the following advantages:
Of the present inventionly be used for the treatment of bronchiectasic pharmaceutical composition, primarily of weight portion: the raw material composition of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts.6 taste herbal raw material medicine sources of composition pharmaceutical composition are wide, cost is low, described pharmaceutical composition is easy to use, without irritated, have no side effect, treating both the principal and secondary aspects of a disease, there are clearing heat and moistening lung, to eliminate the phlegm evacuation of pus, regulate the flow of vital energy and hold back effect of blood, significantly can improve the doctor trained in Western medicine symptom (cough of phlegm-heat obstructing lung type bronchiectasis patient, expectoration, spitting of blood) and tcm symptom (cough rough, the thick Huang of abundant expectoration, expectorant blood is spat blood, fever of the body is thirsty, fullness in the epigastrium and chest, constipation, red tongue with yellow fur, slippery and rapid pulse etc.), can maintain or improve pulmonary function, acute attack can be reduced, antibiotics consumption can be reduced, thus improve the quality of life of patient, through clinical verification effective percentage 96%.And the weight portion of each raw material of Chinese medicine of pharmaceutical composition of the present invention is the conspiracy relation after performance according to Chinese medicine (comprising nature and flavor, lifting sink-float, Gui Jing, toxicity etc.) and compatibility, grope through long-term clinical practice, final summary, determine to reaching optimum therapeuticing effect weight portion, each raw material of Chinese medicine consumption is excessive, easily injures healthy energy or causes poisoning; Consumption is too small, as an utterly inadequate amount, the delay state of an illness.
Further, described pharmaceutical composition is the medicine of decoction, pill, powder, unguentum, sublimed preparation, atomized inhalation, granule, tablet or syrup form or medicament or preparation.Easy to use, be convenient to manufacture.
The pharmaceutical composition of decoction form of the present invention is easy to make, and have capacity large, absorb fast, instant effect, motility is strong, can with the advantage of card plus-minus change.
The formation method of the pharmaceutical composition of decoction form of the present invention, processing technology is simple, is convenient to batch production.
Accompanying drawing explanation
Fig. 1 is the schematic flow sheet of the formation method of the pharmaceutical composition of decoction form of the present invention.
Detailed description of the invention
As background technology sayed, prior art is treated bronchiectasic means and also be there is many deficiencies.
For this reason, the invention provides one and be used for the treatment of bronchiectasic pharmaceutical composition, cheap, safety non-toxic, prepares easy, and patient is easy to accept.
For enabling above-mentioned purpose of the present invention, feature and advantage more become apparent, and are described in detail specific embodiments of the invention below in conjunction with accompanying drawing.
Provide one in one embodiment of the invention and treat bronchiectasic pharmaceutical composition, the raw material primarily of following weight parts forms:
Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts.
Described Radix Platycodonis is monarch drug, has out lung qi dispersing gas, an effect of evacuation of pus of eliminating the phlegm, and Radix Platycodonis is the medicine that treatment bronchiectasis plays primary treatment effect.
Described Radix Scutellariae is ministerial drug, has the effect of heat clearing and damp drying, eliminating fire and detoxication, and the efficacy of a drug of Radix Scutellariae is less than the efficacy of a drug of Radix Platycodonis, and Radix Scutellariae can assist monarch drug to treat bronchiectasis on the one hand, can treat the accompanied symptoms or double sick that bronchiectasis produces on the other hand.
Described Herba Houttuyniae is adjuvant drug, has the effect of lung-heat clearing and detoxification, eliminating carbuncle evacuation of pus, and Herba Houttuyniae can assist monarch, ministerial drug to strengthen treating bronchiectasic effect on the one hand, or the accompanied symptoms that directly treatment is secondary; Toxicity that is main, ministerial drug be can eliminate or slow down on the other hand, monarch, the high strong property of ministerial drug maybe can be restricted; Again on the one hand, the effect of using corrigent can be played.
Described Semen Armeniacae Amarum is adjuvant drug, has the effect of lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, and Semen Armeniacae Amarum can coordinate monarch-minister drug to treat accompanied symptoms, or suppresses the toxicity of monarch-minister drug, or plays using corrigent.
Described Cacumen Platycladi is adjuvant drug, has the effect of hemostasis removing heat from blood, eliminating phlegm and stopping cough, and Cacumen Platycladi can coordinate monarch-minister drug to treat accompanied symptoms, or suppresses the toxicity of monarch-minister drug, or plays using corrigent.
Described Radix Glycyrrhizae Preparata, for making medicine, has the effect of coordinating the actions of various ingredients in a prescription, relieving cough and resolving phlegm, and Radix Glycyrrhizae Preparata can guide above-mentioned all medicines to go directly diseased region, or is in harmonious proportion above-mentioned all medicines.
In addition, the active ingredient such as the Radix Platycodonis in pharmaceutical composition, Radix Scutellariae, Herba Houttuyniae, Cacumen Platycladi, Radix Glycyrrhizae Preparata also has antiinflammatory, anti-microbial effect in various degree; The effect that effective ingredient platycodin in Radix Platycodonis, the effective ingredient amygdaloside in Semen Armeniacae Amarum all have significant prolongation cough latent period, reduce cough number of times, promote trachea excretion; Baicalin has antiallergic, refrigeration function concurrently; There is antibacterial summation action when Herba Houttuyniae effective ingredient houttuynine sodium bisulfite and Antibiotic combination application, and have the effect of resisting pseudomonas aeruginosa biomembrane; Volatile oil in Cacumen Platycladi and flavones ingredient and etamsylate are shortening zero difference on clotting time of mice, can treat various hemorrhagic condition.
Thus, the pharmaceutical composition primarily of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts composition that the embodiment of the present invention provides, the weight portion of each raw material of Chinese medicine of pharmaceutical composition of the present invention is the conspiracy relation after performance (comprising nature and flavor, lifting sink-float, Gui Jing, toxicity etc.) according to Chinese medicine and compatibility, grope through long-term clinical practice, final summary, determine to reaching optimum therapeuticing effect weight portion, each raw material of Chinese medicine consumption is excessive, easily injures healthy energy or causes poisoning; Consumption is too small, as an utterly inadequate amount, the delay state of an illness.The pharmaceutical composition formed by the important source material of above-mentioned weight portion has that lung heat clearing expels the heat-evil, evacuation of pus of eliminating the phlegm, hemostasis of regulating the flow of vital energy effect, the cause of disease that the phlegm-heat obstructing lung type bronchiectasis that hited produces.
" part " of needing each raw material in the present invention illustrated is unit of quantity, and be pro-rata, the comparison component namely in pharmaceutical composition between various raw material is relative usage, is the amount of macroscopic view.
It should be noted that, pharmaceutical composition of the present invention except comprising said medicine, can also comprise other as ministerial drug, adjuvant drug or the medicine making medicine.
In another embodiment of the invention, in described pharmaceutical composition, described Radix Platycodonis 5 ~ 12 parts, Radix Scutellariae 5 ~ 12 parts, Herba Houttuyniae 10 ~ 25 parts, 5 ~ 10 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 18 parts, Radix Glycyrrhizae Preparata 5 ~ 10 parts.The pharmaceutical composition of the combination of this weight portion can reach better therapeutic effect.
In another embodiment of the invention, in described pharmaceutical composition, Radix Platycodonis is 10 ~ 20 parts, Radix Scutellariae is 10 ~ 20 parts, Herba Houttuyniae is 20 ~ 30 parts, Semen Armeniacae Amarum is 10 ~ 15 parts, Cacumen Platycladi 8 ~ 20 parts, Radix Glycyrrhizae Preparata are 8 ~ 12 parts.The pharmaceutical composition of the combination of this weight portion can reach better therapeutic effect.
It should be noted that, aforementioned pharmaceutical compositions can be the medicine of decoction, pill, powder, unguentum, sublimed preparation, atomized inhalation, granule, tablet or syrup form or medicament or preparation.Described pharmaceutical composition can also be other forms of medicine or medicament or preparation.
Present invention also offers a kind of pharmaceutical composition being used for the treatment of bronchiectasic decoction form, the raw material primarily of following weight parts forms:
Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts and 50 ~ 100 parts, water.
As a specific embodiment, the pharmaceutical composition of described decoction form by: Radix Platycodonis 10 parts, Radix Scutellariae 10 parts, Herba Houttuyniae 20 parts, 8 parts, Semen Armeniacae Amarum, Cacumen Platycladi 15 parts, Radix Glycyrrhizae Preparata 9 parts and 80 parts, water form.
In another embodiment of the invention, the pharmaceutical composition of decoction form is primarily of Radix Platycodonis 5 ~ 12 parts, Radix Scutellariae 5 ~ 12 parts, Herba Houttuyniae 10 ~ 25 parts, 5 ~ 10 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 18 parts, Radix Glycyrrhizae Preparata 5 ~ 10 parts and 50 ~ 100 parts, water composition.
The pharmaceutical composition of decoction form have capacity large, absorb fast, instant effect, motility is strong, can with the advantage of card plus-minus change.
Present invention also offers a kind of formation method of pharmaceutical composition of decoction form, please refer to Fig. 1,
Carry out step S101, the raw material of Chinese medicine of following weight parts is provided: Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts.
In the present embodiment, to form the decoction of potion (150 ~ 200ml) consumption exemplarily, described raw material of Chinese medicine is: Radix Platycodonis 10 grams, Radix Scutellariae 10 grams, Herba Houttuyniae 20 grams, 8 grams, Semen Armeniacae Amarum, Cacumen Platycladi 15 grams, Radix Glycyrrhizae Preparata 9 grams.
In another specific embodiment, when forming the decoction of potion consumption, described raw material of Chinese medicine is: Radix Platycodonis 10 grams, Radix Scutellariae 10 grams, Herba Houttuyniae 20 grams, 10 grams, Semen Armeniacae Amarum, Cacumen Platycladi 15 grams, Radix Glycyrrhizae Preparata 9 grams.
In another specific embodiment, when forming the decoction of potion consumption, described raw material of Chinese medicine is: Radix Platycodonis 20 grams, Radix Scutellariae 20 grams, Herba Houttuyniae 30 grams, 15 grams, Semen Armeniacae Amarum, Cacumen Platycladi 25 grams, Radix Glycyrrhizae Preparata 9 grams.
Carry out step S102, described raw material of Chinese medicine is placed in and decocts in container, in decoction container, add pure water, soak 20 ~ 40 minutes.
Described decoction container is nonmetal, utensil non-chemically, and to prevent the pollution of metal and chemical element in fried decoction, affect the therapeutic effect of decoction, the material of such as described decoction container can be marmite or pottery.Described decoction container has decocting the closed upper cover of vessel port, and in the process decocted, described upper cover covers on decoction container, in order to avoid flavour of a drug volatilization.
In the present embodiment, the mass parts of the pure water added can for 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing.The metering method of this pure water weight portion is comparatively accurate, is specially adapted to making of prescription (decoction) that medicament categories is many, dose is large.
In the present embodiment, the raw material of Chinese medicine weight portion provided is Radix Platycodonis 10 parts, Radix Scutellariae 10 parts, Herba Houttuyniae 20 parts, 8 parts, Semen Armeniacae Amarum, Cacumen Platycladi 15 parts, Radix Glycyrrhizae Preparata 9 parts, raw material of Chinese medicine total weight parts is 72 parts, the mass parts of the pure water added is 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing, and the weight portion thus adding pure water is 432 ~ 864 parts.
In the particular embodiment, the raw material of Chinese medicine weight provided is Radix Platycodonis 10 grams, Radix Scutellariae 10 grams, Herba Houttuyniae 20 grams, 8 grams, Semen Armeniacae Amarum, Cacumen Platycladi 15 grams, Radix Glycyrrhizae Preparata 9 grams, raw material of Chinese medicine gross weight is 72 grams, the quality of the pure water added is 6 ~ 12 times of raw material of Chinese medicine gross weight of providing, and the weight thus adding pure water is 432 ~ 864 grams.
In other embodiments of the invention, described in the pure water that adds exceed 2 ~ 3 centimetres of powder, in the embodiment of the present invention, the powder of indication is laid in by raw material when decocting in container, decocts the surface of the raw material exposed in container.
Described pure water is the clean water at least meeting drinking water standard.
Before decoction step, by raw material soaking 20 ~ 40 minutes, to make raw material fully moistening, fully fried in order to medicine juice.
Carry out step S103, described raw material of Chinese medicine is decocted; Carry out step S104, filtering medicinal residues, obtain decoction.
In the present embodiment, described decoction comprises head and decocts and secondary decoction, raw material of Chinese medicine by weight portion: Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts are placed in and decoct after in container, decocting the pure water adding the first weight portion in container, carry out head to decoct, filtering raw material of Chinese medicine, obtains head and decocts decoction; Raw material of Chinese medicine after decocting for correct time adds the pure water of the second weight portion, carries out secondary decoction, filtering medicinal residues, obtains secondary decoction; By head time decoction and the mixing of secondary decoction, form decoction.
The total weight parts of the pure water of the first weight portion and the pure water of the second weight portion is 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing, and the weight portion that the weight portion of the pure water of the first weight portion is the pure water of the 60% ~ 70%, second weight portion of the total weight parts of pure water is 30% ~ 40% of the total weight parts of pure water.
In the present embodiment, the raw material of Chinese medicine weight portion provided is Radix Platycodonis 10 parts, Radix Scutellariae 10 parts, Herba Houttuyniae 20 parts, 8 parts, Semen Armeniacae Amarum, Cacumen Platycladi 15 parts, Radix Glycyrrhizae Preparata 9 parts, raw material of Chinese medicine total weight parts is 72 parts, the total weight parts of the pure water of the first weight portion added and the pure water of the second weight portion is 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing, it is 432 ~ 864 parts, the total weight parts of such as pure water can be 10 times for the raw material of Chinese medicine total weight parts provided, be specially 720 parts, and the weight portion of the pure water of the first weight portion is 60% ~ 70% of the total weight parts of pure water, concrete can be 65% of the total weight parts of pure water, when the total weight parts of such as pure water is 720 parts, the weight portion of the pure water of the first weight portion is 468 parts, the weight portion of the pure water of the second weight portion is 30% ~ 40% of the total weight parts of pure water, concrete can be 35% of the total weight parts of pure water, when the total weight parts of such as pure water is 720 parts, the weight portion of the pure water of the second weight portion is 252 parts.The pure water of the first weight portion and the pure water accounting sum of the second weight portion are 100%.
In the particular embodiment, the raw material of Chinese medicine weight provided is Radix Platycodonis 10 grams, Radix Scutellariae 10 grams, Herba Houttuyniae 20 grams, 8 grams, Semen Armeniacae Amarum, Cacumen Platycladi 15 grams, Radix Glycyrrhizae Preparata 9 grams, raw material of Chinese medicine gross weight is 72 grams, the gross mass of the pure water added is 6 ~ 12 times of raw material of Chinese medicine gross weight of providing, thus the pure water gross weight added is 432 ~ 864 grams, concrete, the pure water gross weight added is 720 grams, the weight of the pure water of the first weight portion is the 65%(or 60% ~ 70% of the gross weight of pure water), it is 468 grams, the weight portion of the pure water of the second weight portion is the 35%(or 30% ~ 40% of the gross weight of pure water), it is 252 grams.
Carry out head to decoct and secondary decoction, the process of described decoction, for first boiling with high heat, then decocts with slow fire.
The intense fire intensity of a fire is anxious, and firepower is violent, and temperature rises fast, and moisture evaporation is fast, the slow fire intensity of a fire is delayed, and firepower is weak, and temperature rises slow, and moisture evaporation is slow, the temperature of concrete described intense fire is 180 ~ 190 degrees Celsius, and slow fire is 100 ~ 150 degrees Celsius, and the total time of decoction is 15 ~ 25 minutes.When decoction process is divided into head to decoct and secondary decoction, the time that head decocts is 20 ~ 25 minutes, and the time that secondary decocts is 10 ~ 20 minutes.
In the embodiment of the present invention, head is decocted decoction and secondary medicinal liquid mixing formation decoction, take full advantage of important source material, and guarantee the equalization ensureing the decoction efficacy of a drug.
The pharmaceutical composition clinical therapeutic efficacy of decoction form of the present invention:
Criterion of therapeutical effect: whether the Outcome measure Main Basis of the medicine composite for curing phlegm-heat obstructing lung type bronchiectasis of decoction form of the present invention props up expansion symptom (cough, expectoration, spitting of blood) in phlegm-heat obstructing lung type and disappear.Taking medicine 30 days is 1 course for the treatment of.Concrete curative effect divides following three grades: cure---and phlegm-heat obstructing lung type props up expansion symptom and all disappears; Taking a turn for the better---phlegm-heat obstructing lung type props up and expands symptom partial disappearance; Invalid---after 1 course for the treatment of of taking medicine, phlegm-heat obstructing lung type props up expansion symptom to be had no to disappear.
Effect: by medicine composite for curing phlegm-heat obstructing lung type bronchiectasis patient 50 example of decoction form of the present invention, treat 1 course for the treatment of, wherein cure 40 examples, take a turn for the better 8 examples, and invalid 2 examples, cure rate is 80%, and effective percentage is 96%.
Model case:
Chen, female, 55 years old, peasant.In January, 2013 goes to a doctor.Patient recurrent cough, cough yellow sputum 3 years, to rise morning obviously, nearest 1 month every average daily expectoration tens mouthfuls of yellow sputum, even companion coughs up a little kermesinus bloody sputum.Once did chest high-resolution ct, be diagnosed as " twice pulmonary branches tracheaectasies ".Adopt the pharmaceutical composition of decoction form of the present invention, first take the l course for the treatment of, symptom progressively alleviates, and follow-uply takes for 2 courses for the treatment of, and symptom is fully recovered.Visit after 6 months, have no recurrence.
In the embodiment of the present invention, additionally provide the formation method of pharmaceutical composition of pill, powder, unguentum, sublimed preparation, atomized inhalation, granule, tablet form, specific as follows:
The formation method of the pharmaceutical composition of pill is: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, then with the pellet preparation that the mixings such as water or honey, batter, rice paste, medicine juice, Cera Flava become to differ in size.
The formation method of the pharmaceutical composition of powder form is: by the raw material pulverize of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, sieve.When taking, use water is taken after mixing with liquid, or decocts soup and take.Powder has that the absorption of decoction is fast concurrently, effect rapidly, and the feature such as the consumption of pill is little, easily carry.
The formation method of the pharmaceutical composition of ointment is: being added water by the raw material of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts decocts, elimination dregs, then the soft extract adding that crystal sugar, Mel etc. are boiled into stiff.
The formation method of the pharmaceutical composition of sublimed preparation form is: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, be refined into the preparation of pellet, ingot shape.
The formation method of the pharmaceutical composition of tablet form is: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, or make fluid extract, then add excipient (as starch) and be pressed into Formulation.Tablet is easy to carry and use, applies very extensive.
The formation method of the pharmaceutical composition of granular form comprises the method such as wet granulation and dry granulation.Wherein the method for wet granulation comprises: refer to the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts or thick paste to put in suitable container with adjuvant mix homogeneously, add the soft material that wetting agent makes " hands is pinched agglomerating; namely faling apart of pressure ", pass through l4 ~ 22 eye mesh screen (plate) with fashion of extrusion again, make uniform granule.Prepare sieve of can granulating by hand in a small amount, the multiplex oscillating granulator of large production or rotary granulator.Or also can pass through fluidized-bed spray granulation, make material powder preheating and drying and be in fluidized state, then make powder wetted and condense into cellular granule, continue to be dried to water content in granule and be suitable for and get final product.Or also can pass through spray-drying process, by the mixing slurry of the medical material lixiviating solution after suitable process or medicine, adjuvant, spray-driedly be made in extract powder, then adding adjuvant, for extruding grain mechanism grain.
The formation method of the pharmaceutical composition of syrup form comprises thermosoling, cold cut and mixing method.Thermosoling, sucrose is added in a certain amount of drug solution (drug solution that Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts obtain) boiled, continue heating and make dissolving, filtered while hot.Cold cut, adds sucrose in drug solution, stirred at ambient temperature, filters after dissolving completely.Mixing method, adds simple syrup and other additives (as antiseptic, aromatic etc.) in drug solution, and fully after mixing, adding distil water, to ormal weight, leaves standstill, filters.
The formation method of the pharmaceutical composition of atomized inhalation form is: distill after the raw material adding distil water of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, collect distillate, leaching concentration of liquid medicine, to cold, add ethanol in proper amount, fully stir, precipitation is got supernatant and is reclaimed ethanol extremely without alcohol taste, reconcentration, cool centrifugal after add appropriate distilled water and make Neulized inhalation liquid.
To sum up, the pharmaceutical composition of the embodiment of the present invention, medicine source is wide, cost is low, described pharmaceutical composition is easy to use, without irritated, have no side effect, treating both the principal and secondary aspects of a disease, there are clearing heat and moistening lung, evacuation of pus of eliminating the phlegm, regulate the flow of vital energy and hold back effect of blood, significantly can improve doctor trained in Western medicine symptom and the tcm symptom of phlegm-heat obstructing lung type bronchiectasis patient.
The formation method of the pharmaceutical composition of the embodiment of the present invention, processing technology is simple, is convenient to batch production.
Although the present invention discloses as above, the present invention is not defined in this.Any those skilled in the art, without departing from the spirit and scope of the present invention, all can make various changes or modifications, and therefore protection scope of the present invention should be as the criterion with claim limited range.
Claims (20)
1. be used for the treatment of a bronchiectasic pharmaceutical composition, it is characterized in that, the raw material primarily of following weight parts forms:
Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts.
2. be used for the treatment of bronchiectasic pharmaceutical composition as claimed in claim 1, it is characterized in that, in described pharmaceutical composition, described Radix Platycodonis 5 ~ 12 parts, Radix Scutellariae 5 ~ 12 parts, Herba Houttuyniae 10 ~ 25 parts, 5 ~ 10 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 18 parts, Radix Glycyrrhizae Preparata 5 ~ 10 parts.
3. be used for the treatment of bronchiectasic pharmaceutical composition as claimed in claim 1, it is characterized in that, in described pharmaceutical composition, Radix Platycodonis is 10 ~ 20 parts, Radix Scutellariae is 10 ~ 20 parts, Herba Houttuyniae is 20 ~ 30 parts, Semen Armeniacae Amarum is 10 ~ 15 parts, Cacumen Platycladi 8 ~ 20 parts, Radix Glycyrrhizae Preparata are 8 ~ 12 parts.
4. be used for the treatment of bronchiectasic pharmaceutical composition as claimed in claim 1, it is characterized in that, described pharmaceutical composition is the medicine of decoction, pill, powder, unguentum, sublimed preparation, atomized inhalation, granule, tablet or syrup form or medicament or preparation.
5. be used for the treatment of a pharmaceutical composition for bronchiectasic decoction form, it is characterized in that, the raw material primarily of following weight parts forms:
Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts and 50 ~ 100 parts, water.
6. a formation method for the pharmaceutical composition of decoction form as claimed in claim 5, is characterized in that, comprising:
There is provided the raw material of Chinese medicine of following weight parts: Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts;
Described raw material of Chinese medicine is placed in and decocts in container, the pure water added in decoction container;
Described raw material of Chinese medicine is decocted;
Filtering medicinal residues, obtain decoction.
7. a formation method for the pharmaceutical composition of decoction form as claimed in claim 6, is characterized in that, before decocting raw material of Chinese medicine, raw material of Chinese medicine is soaked 20 ~ 40 minutes in pure water.
8. a formation method for the pharmaceutical composition of decoction form as claimed in claim 6, described in the pure water that adds exceed 2 ~ 3 centimetres of powder, or described in the pure water weight portion that adds be 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing.
9. a formation method for the pharmaceutical composition of decoction form as claimed in claim 6, is characterized in that, described decoction process comprises head and decocts and secondary decoction, decocting the pure water adding the first weight portion in container, carry out head to decoct, filtering raw material of Chinese medicine, obtain head and decoct decoction; Raw material of Chinese medicine after decocting for correct time adds the pure water of the second weight portion, carries out secondary decoction, filtering medicinal residues, obtains secondary decoction; By head time decoction and the mixing of secondary decoction, form decoction.
10. the formation method of the pharmaceutical composition of a decoction form as claimed in claim 9, the total weight parts of the pure water of the first weight portion and the pure water of the second weight portion is 6 ~ 12 times of raw material of Chinese medicine total weight parts of providing, and the weight portion that the weight portion of the pure water of the first weight portion is the pure water of the 60% ~ 70%, second weight portion of the total weight parts of pure water is 30% ~ 40% of the total weight parts of pure water.
The formation method of the pharmaceutical composition of 11. 1 kinds of decoction forms as described in claim 6 or 10, is characterized in that, the process of described decoction, for first boiling with high heat, then decocts with slow fire.
The formation method of the pharmaceutical composition of 12. 1 kinds of decoction forms as claimed in claim 11, is characterized in that, the temperature of described intense fire is 180 ~ 190 degrees Celsius, and slow fire is 100 ~ 150 degrees Celsius, and the time of decoction is 15 ~ 25 minutes.
The formation method of the pharmaceutical composition of 13. 1 kinds of pill, it is characterized in that, comprise: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, then with the pellet preparation that water, honey, batter, rice paste, medicine juice or Cera Flava mixing become to differ in size.
The formation method of the pharmaceutical composition of 14. 1 kinds of powder form, it is characterized in that, comprising: by the raw material pulverize of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, sieve.
The formation method of the pharmaceutical composition of 15. 1 kinds of ointment, it is characterized in that, comprise: being added water by the raw material of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts decocts, elimination dregs, then the soft extract adding that crystal sugar or Mel are boiled into stiff.
The formation method of the pharmaceutical composition of 16. 1 kinds of sublimed preparation forms, it is characterized in that, comprise: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, be refined into the preparation of pellet, ingot shape.
The formation method of the pharmaceutical composition of 17. 1 kinds of tablet forms, it is characterized in that, comprise: by the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, or make fluid extract, then add excipient and be pressed into Formulation.
The formation method of the pharmaceutical composition of 18. 1 kinds of granular form, it is characterized in that, comprising: refer to the raw material pulverization of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts or thick paste; Put in container with adjuvant and mix homogeneously, add the soft material that wetting agent is made; Pass through l4 ~ 22 eye mesh screen with fashion of extrusion again, make uniform granule.
The formation method of the pharmaceutical composition of 19. 1 kinds of syrup form, it is characterized in that, comprise: sucrose is added a certain amount of boil by Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts of drug solutions formed, continue heating and make sucrose dissolved, filtered while hot, makes syrup.
The formation method of the pharmaceutical composition of 20. 1 kinds of atomized inhalation forms, it is characterized in that, comprise: distill after the raw material adding distil water of Radix Platycodonis 5 ~ 20 parts, Radix Scutellariae 5 ~ 20 parts, Herba Houttuyniae 10 ~ 30 parts, 5 ~ 18 parts, Semen Armeniacae Amarum, Cacumen Platycladi 8 ~ 25 parts, Radix Glycyrrhizae Preparata 5 ~ 16 parts, collect distillate, leaching concentration of liquid medicine, to cold, add ethanol in proper amount, fully stir, precipitation is got supernatant and is reclaimed ethanol extremely without alcohol taste, reconcentration, cool centrifugal after add distilled water and make Neulized inhalation liquid.
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| CN101181556A (en) * | 2007-11-21 | 2008-05-21 | 胡公英 | Chinese medicine prescription orally taken for curing chronic bronchitis |
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Application publication date: 20150729 |