CN104800261A

CN104800261A - Clove compound mouthwash

Info

Publication number: CN104800261A
Application number: CN201510250094.2A
Authority: CN
Inventors: 蒋革; 祁玉丽; 罗锋
Original assignee: Dalian University
Priority date: 2015-05-15
Filing date: 2015-05-15
Publication date: 2015-07-29
Anticipated expiration: 2035-05-15
Also published as: CN104800261B

Abstract

The invention discloses clove compound mouthwash, which comprises the following ingredients in percentage by mass: 0.2 to 0.4 percent of tea polyphenol, 0.5 to 1 percent of eugenol, 0.17 to 0.2 percent of pseudo-ginseng extracts (20:1), 3 to 6 percent of active ingredient stabilizing agents, 0.5 to 1 percent of active ingredient regulating agents, 0.1 to 1 percent of sweetening agents, 0.02 to 1 percent of sour agents, 2 to 5 percent of wetting agents, 0.5 to 1 percent of essence, 0.05 percent of fluoride, 0.01 to 0.4 percent of edible antiseptics and the balance deionized water, wherein the tea polyphenol, the eugenol and the pseudo-ginseng extracts are active ingredients in the mouthwash. The eugenol has the inhibition effect on the pathogenic bacteria and the fungi, a certain antioxidation effect and a certain anti-cancer effect are also achieved, the flavor is unique, the anti-bacterium and anti-oxidation effects of the tea polyphenol are also very good, the tea polyphenol is widely applied to toothpaste, the pseudo-ginseng has better blood circulation promotion and anti-inflammation effects, and a good inhibition effect is achieved on major harmful bacteria in oral cavity resident flora.

Description

A kind of Flos Caryophylli compound recipe collutory

Technical field

The present invention relates to a kind of multifunctional pure natural mouthwash being primary raw material with Flos Caryophylli, tea polyphenols, Radix Notoginseng, belong to collutory field.

Background technology

Along with improving constantly of society living standard, also changing gradually again of people's dietary habit, adds living habit bad at ordinary times, emerges many oral problem thus, as periodontitis, dental caries, halitosis, oral ulcer etc.Collutory is the novel product of Technology Times, the pharmaceutical compositions of multiple treatment oral cavity, laryngopharyngeal diseases matches and develops and can directly act on site of disease by researcher, also can remove because of mouth disease, the collutory eating the halitosis that peculiar smell foodstuff, dyssomnia, psychentonia, dyspepsia etc. cause.Traditional collutory contains more ethanol, has certain harm to oral cavity, and portioned product, for reaching ideal effect, is not stinted and added chemosynthesis reagent, to improve the effect of collutory, and this way, concerning user, there is very large potential safety hazard.Plants essential oil class collutory composition novel is at present natural, have strong, the non-specific sterilization of permeability, effect is fast, the feature that effective acting time is long, side effect is little, and oral care product field is widely used at home.In addition natural Chinese medicine composition has other some biological activitys, can strengthen body immunity, has the effect of prevention and therapy cancer.

The domestic development to this kind of collutory containing natural Chinese medicinal herb composition is little at present, and existing Patents, some composition is too single, and some lacks corresponding experiment, can not ensure the safety of collutory.

Summary of the invention

The object of the present invention is to provide a kind of Flos Caryophylli compound recipe collutory, there is the effect of sterilization, preventing decayed tooth, detumescence, stop blooding, brighten, be good for tooth, fresh breath, and safe and reliable, easy to use.

A kind of Flos Caryophylli compound recipe collutory, comprises following composition according to mass percentage:

Tea polyphenols 0.2 ~ 0.4%, eugenol 0.5 ~ 1%, Radix Notoginseng extract 0.17 ~ 0.2%; Tea polyphenols, eugenol, Radix Notoginseng extract is the active component in collutory;

Active component stabilizing agent 3 ~ 6%, active component regulator 0.5 ~ 1%, sweeting agent 0.01 ~ 1%, acidic flavoring agent 0.02 ~ 1%, wetting agent 2 ~ 5%, essence 0.5 ~ 1%, fluoride 0.05%, food antiseptics 0.01 ~ 0.4%, all the other are deionized water.

Further, in technique scheme, described sweeting agent is selected from one or more in saccharin sodium, Sorbitol, xylitol, fructose, stevioside.

Further, in technique scheme, described fluoride be selected from sodium fluoride or sodium monofluorophosphate one or both.

Further, in technique scheme, described acidic flavoring agent is selected from the one in malic acid, citric acid or tartaric acid.

Further, in technique scheme, described active component stabilizing agent adopts a kind of in polyoxyethylene ether (40) castor oil hydrogenated, sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride or their mixture.

Further, in technique scheme, described active component regulator is one or both in sodium lauryl sulphate and lauryl creatine acid.

Further, in technique scheme, described wetting agent adopts glycerol or sorbitol.

Further, in technique scheme, described essence adopts peafowl essence, menthol.

Further, in technique scheme, described food antiseptics for Buddhist nun moor second gold ester.

Above-mentioned Flos Caryophylli compound recipe collutory is prepared by the following method:

1) by above-mentioned content, sweeting agent, acidic flavoring agent and essence are stirred to dissolving in water, then wetting agent and food antiseptics are joined in sterilized water, stir to clarify transparent finely dispersed aqueous solution;

2) prepare eugenol mother solution: in eugenol, add sterilized water, be heated to 30-50 DEG C, add PEG-40, stirring and dissolving is to clarification; Obtain the eugenol mother solution of 40mg/mL;

Tea blend polyphenol mother solution: add sterilized water in tea polyphenols, stirring and dissolving is to clarification; Be prepared into the tea polyphenol mother solution that ultimate density is 40mg/mL;

Preparation Radix Notoginseng mother solution: add sterilized water in Radix Notoginseng extract (20:1), stirring and dissolving is to clarification; Be prepared into the Radix Notoginseng extract mother solution that ultimate density is 20mg/mL;

The preparation of sodium fluoride mother solution: get sodium fluoride and be dissolved in sterilized water, is prepared into the sodium fluoride mother solution that ultimate density is 10mg/mL;

Above-mentioned four kinds of mother solutions are mixed, and adds PEG-40, obtain active component mother solution in collutory;

3) under stirring, by step 1) in aqueous solution slowly join step 2) in configuration active component mother solution in, stop stir, after overnight stand, filter, obtain finished product after aseptic process.

The invention provides the purposes of above-mentioned collutory, this collutory can be used for the oral disease such as treatment or pre-preventing parodontitis, dental caries, halitosis, oral ulcer, has the effect brightening, be good for tooth, clearing heat for detumescence, prophylaxis of cancer.

The using method of this collutory: get this product in right amount, about 10-20ml, rinsing the mouth is about 30s, spues, without the need to gargling with clear water again.

Invention beneficial effect

Eugenol in the present invention has inhibitory action to malignant bacteria and fungus, also there is antioxidation and certain antitumaous effect, and abnormal smells from the patient is unique, tea polyphenols antibacterial, antioxidant effect is also very good, be widely used in toothpaste, Radix Notoginseng has stronger anti inflammatory blood quickening effect, has fine inhibitory action to the main harmful bacteria that oral cavity is resided in bacterium.Multiple components combines by the present invention, except the function of cleaning oral cavity with different collutory, also has the oral disease such as treatment or pre-preventing parodontitis, dental caries, halitosis, oral ulcer, brighten, is good for effect of tooth, clearing heat for detumescence, prophylaxis of cancer.There is multiple effect of preventing and treating oral disease.This collutory adopts natural plant composition, has better safety than the collutory on existing market.

Accompanying drawing explanation

Fig. 1 is that embodiment 1 collutory is to the inhibition figure of staphylococcus aureus, escherichia coli, bacillus subtilis, Candida albicans;

Fig. 2 is the inhibition figure a of embodiment 1 collutory to Oral Bacteria;

Fig. 3 is the inhibition figure b of embodiment 1 collutory to Oral Bacteria.

Detailed description of the invention

Following nonlimiting examples can make the present invention of those of ordinary skill in the art's comprehend, but does not limit the present invention in any way.Eugenol, is purchased from Jiangxi Cedrus deoclar (Roxb.) G. Don natural medicinal plant oil company limited, density 1.063-1.068g/ml; Tea polyphenols, is purchased from Xuancheng BAICAO plant Trade Co., Ltd.; Radix Notoginseng extract (20:1) is purchased from bright biological development corporation, Ltd. of Baoji side.

Embodiment 1

Flos Caryophylli compound recipe collutory, following composition is comprised: eugenol 1% according to mass percentage, tea polyphenols 0.2%, Radix Notoginseng extract (20:1) 0.17%, NaF 0.05%, PEG-40 3%, glycerol 5%, K12 0.5%, Sorbitol 0.01%, malic acid 0.02%, menthol 0.5%, sterilized water surplus.

Preparation method, the production for 100ml:

(1) preparation of effective ingredient mother solution,

The preparation of eugenol mother solution: get 3.756ml eugenol (ρ=1.063 ~ 1.068g/ml), first add a small amount of sterilized water, put into magnetic stirring apparatus to heat while stirring, heating-up temperature is 40 DEG C, add PEG-40 (6 ~ 10ml) gradually to solution clarification, then supplement distilled water to 100ml.Be prepared into the eugenol mother solution that ultimate density is 40mg/mL.

The preparation of tea polyphenol mother solution: get 4g tea polyphenols and be dissolved in 100ml sterilized water, is prepared into the tea polyphenol mother solution that ultimate density is 40mg/mL.

The preparation of Radix Notoginseng extract mother solution: get 2 Radix Notoginseng extracts (20:1) and be dissolved in 100ml sterilized water, is prepared into the Radix Notoginseng extract mother solution that ultimate density is 20mg/mL.

The preparation of sodium fluoride mother solution: get 1g sodium fluoride and be dissolved in 100ml sterilized water, is prepared into the sodium fluoride mother solution that ultimate density is 10mg/mL.

(2) above-mentioned eugenol mother solution 25ml, tea polyphenol mother solution 5ml, Radix Notoginseng extract mother solution 8.33ml, sodium fluoride is got

Mother solution 5ml, adds PEG-40 1ml gradually and clarifies to solution, and available ultrasonic dissolution obtains effective ingredient mother solution mixed liquor;

(3) get 55.67ml sterilized water and add glycerol 5g, K12 0.5g, Sorbitol 0.01g, malic acid 0.02g, menthol 0.5g, Nipagin ester 0.1g, limit edged stirs to clarify transparent finely dispersed aqueous solution;

(4) under stirring, by step 1) in aqueous solution slowly join step 2) in configuration active component mother solution in, after mix homogeneously, stop stir, after overnight stand, filter, obtain finished product after aseptic process.

Antibacterial test 1

The fungistatic effect of active component in collutory is represented by the growth curve measuring antibacterial, method is: sterile working, adopt the Flos Caryophylli compound recipe collutory obtaining liq culture medium in embodiment 1, do not add the fluid medium of effective ingredient together, take blank cultures as contrast, under 600nm, measure initial OD values.Get the bacterium liquid 3ml of cultivation 8 ~ 12h again, join in aforesaid liquid culture medium, survey an OD value again, as the OD value of 0h, measure an OD value every 2h later, survey again once after surveying 8h, 24h, the OD value in each moment obtained deducts initial absorbance value, does with these numerical value the growth curve that a curve is antibacterial.

To the inhibition of staphylococcus aureus, escherichia coli, bacillus subtilis, Candida albicans in table 1 and Fig. 1:

In table 1 Flos Caryophylli compound recipe collutory, active component is to the inhibition of different bacteria growing

Fig. 2, Fig. 3 are shown in the inhibition of Oral Bacteria, Fig. 2 is the inhibition of collutory to bacterium in certain female oral cavity, Fig. 3 is the inhibition of collutory to bacterium in certain male oral cavity, and wherein negative control is the growing state of Oral Bacteria in the fluid medium containing equal volume normal saline.

Claims

1. a Flos Caryophylli compound recipe collutory, is characterized in that, comprises following composition according to mass percentage:

Tea polyphenols 0.2 ~ 0.4%, eugenol 0.5 ~ 1%, Radix Notoginseng extract (20:1) 0.17 ~ 0.2%, tea polyphenols, eugenol, Radix Notoginseng extract are the active component in collutory; Active component stabilizing agent 3 ~ 6%, active component regulator 0.5 ~ 1%, sweeting agent 0.01 ~ 1%, acidic flavoring agent 0.02 ~ 1%, wetting agent 2 ~ 5%, essence 0.5 ~ 1%, fluoride 0.05%, food antiseptics 0.01 ~ 0.4%, all the other are deionized water.

2. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described sweeting agent is selected from one or more in saccharin sodium, Sorbitol, xylitol, fructose, stevioside.

3. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described fluoride be selected from sodium fluoride or sodium monofluorophosphate one or both.

4. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described acidic flavoring agent is selected from the one in malic acid, citric acid or tartaric acid.

5. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described active component stabilizing agent adopts a kind of in polyoxyethylene ether (40) castor oil hydrogenated, sad certain herbaceous plants with big flowers acid polyethylene glycol glyceride or their mixture.

6. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described active component regulator is one or both in sodium lauryl sulphate and lauryl creatine acid.

7. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described wetting agent adopts glycerol or sorbitol.

8. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described essence adopts peafowl essence, menthol.

9. Flos Caryophylli compound recipe collutory according to claim 1, is characterized in that: described food antiseptics moors second gold ester for Buddhist nun.