CN104784368A

CN104784368A - Externally-used medicine composition for treating chloasma

Info

Publication number: CN104784368A
Application number: CN201510163851.2A
Authority: CN
Inventors: 李健
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-04-09
Filing date: 2015-04-09
Publication date: 2015-07-22

Abstract

The invention discloses externally-used medicine composition for treating chloasma. The composition is prepared from traditional Chinese medicines in parts by weight with a water extraction method as follows: 30-42 parts of salvia chinensis benth, 11-20 parts of calyx seu fructus physalis, 30-42 parts of herba hyperici japonica, 30-42 parts of cissus hexangularis, 11-20 parts of tribulus terrestris, 11-20 parts of mulberry leaves, 6-12 parts of herba artemisiae anomalae, 11-20 parts of silene adenantha, 11-20 parts of eriobotrya japonica thumb and 9-15 parts of dandelion. The externally-used medicine composition has the effects of blood vessel warming and clearing, skin activation, stasis elimination, blood nourishment, freckle removal and skin moisturizing, can effectively expand peripheral vessels, improve microcirculation of the face and soften cutin and has a certain inhibition function on hyperpigmentation.

Description

A kind of externally-applied medicinal composition for the treatment of chloasma

Technical field

The invention belongs to technical field of Chinese medicine, in particular to a kind of externally-applied medicinal composition for the treatment of chloasma.

Background technology

Chloasma is commonly called as chloasma hepaticum, butterfly spot, is common facial pigmentation disease, and it a kind ofly occurs in yellowish-brown not of uniform size around buccal, volume, nose and lip or coffee mottle.Its sickness rate has the trend increased year by year, is mainly in young women, has a strong impact on its live and work.

Chloasma belongs to the traditional Chinese medical science " chloasma ", " dusty face " category, and the traditional Chinese medical science thinks that its etiology and pathogenesis and ailment said due to cold or exposure, phlegm retention, disharmony between QI and blood are relevant.Stagnation of QI due to depression of the liver, qi and blood stagnation, phlegm-damp stagnate, then QI-blood circulation is not smooth, can not moisten foster face skin, dysfunction of the spleen in transportation, and raw in phlegm-damp, no resource of generating and transforming QI and blood, can not go up magnificent skin, then raw brown patch." Prescriptions for Universal Relief " carries: " husband's ailment said due to cold or exposure enters meridians, and vim and vigour stagnate, and muscle is not damp, sends out in verruca, Liver and kidney deficiency of YIN-blood, water failing to restrain blazing fire, and blood is weak can not be flourish in skin outward, and fiery dryness accumulated in the stomach and intestine becomes black speckle." " surgery great achievement " point out: " face of the how raw woman of chloasma, not magnificent by heat in blood, fiery dryness accumulated in the stomach and intestine becomes." according to Epidemiological study, chloasma is a kind of pigmented dermatosis caused by many factors comprehensive function.Domestic and international research display, it is the important paathogenic factor of chloasma that the rising of gestation, oral contraceptive, ultraviolet radiation, oxygen-derived free radicals, Ceruloplasmin, estrogen, progesterone level rising, Nervous and Mental Factors (emotion is not good for a long time) and making applies some make up etc.

At present, the treatment for chloasma there is no the cure method of specially good effect, adopts hormone cosmetics and facial film skin protection maintenance more, though instant effect, easily recurs, cause harm greatly and misery to people's physical and mental health in conventional therapy.

Summary of the invention

The object of the present invention is to provide a kind of externally-applied medicinal composition for the treatment of chloasma, said composition instant effect, good effect, easy and simple to handle, without obvious adverse reaction.

The object of the present invention is achieved like this:

Treat an externally-applied medicinal composition for chloasma, said composition is prepared from by the traditional Chinese medicinal material raw materials comprising following weight portion: Herba Salviae Chinensis 30-42 part, Calyx Seu Fructus Physalis 11-20 part, Herba Hyperici Japonici 30-42 part, Radix Cissi hexangularis 30-42 part, Fructus Tribuli 11-20 part, Folium Mori 11-20 part, Herba Artemisiae Anomalae 6-12 part, HEIQIANNIU 11-20 part, Folium Eriobotryae 11-20 part, Herba Taraxaci 9-15 part.

Preferably, the externally-applied medicinal composition for the treatment of chloasma described above, it is prepared from by the traditional Chinese medicinal material raw materials comprising following weight portion: Herba Salviae Chinensis 34-37 part, Calyx Seu Fructus Physalis 14-16 part, Herba Hyperici Japonici 34-37 part, Radix Cissi hexangularis 34-37 part, Fructus Tribuli 14-16 part, Folium Mori 14-16 part, Herba Artemisiae Anomalae 8-10 part, HEIQIANNIU 14-16 part, Folium Eriobotryae 14-16 part, Herba Taraxaci 11-13 part.

In a most preferred embodiment of the present invention, the externally-applied medicinal composition for the treatment of chloasma described above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Salviae Chinensis 35 parts, Calyx Seu Fructus Physalis 15 parts, Herba Hyperici Japonici 35 parts, Radix Cissi hexangularis 35 parts, Fructus Tribuli 15 parts, 15 parts, Folium Mori, Herba Artemisiae Anomalae 9 parts, HEIQIANNIU 15 parts, Folium Eriobotryae 15 parts, Herba Taraxaci 12 parts.

The preparation method that the present invention treats the pharmaceutical composition of chloasma comprises the steps: to take Herba Salviae Chinensis 30-42 part, Calyx Seu Fructus Physalis 11-20 part, Herba Hyperici Japonici 30-42 part, Radix Cissi hexangularis 30-42 part, Fructus Tribuli 11-20 part, Folium Mori 11-20 part, Herba Artemisiae Anomalae 6-12 part, HEIQIANNIU 11-20 part, Folium Eriobotryae 11-20 part and Herba Taraxaci 9-15 part, add the soak by water 1.5-2h of medical material gross weight 10-20 times amount, filter, collect filtrate; In medicinal residues, add the soak by water 1-1.5h of medical material weight 8-15 times amount again, filter, collect filtrate, twice filtrate is merged, is concentrated into semi-solid extractum, by extractum lyophilization, pulverized 200 mesh sieves, and obtained Chinese medicine extract medicated powder.

It should be noted that, traditional Chinese medicinal material raw materials of the present invention has following source: Herba Salviae Chinensis selects the dry herb of Lamiaceae Salvia platymiscium Herba Salviae Chinensis Salvia chinensia Benth..The dry Constellation calyx of plant of Solanaceae Calyx seu fructus physalis Physalis alkekengi L. var. franchetii (Mast.) Makino selected by Calyx Seu Fructus Physalis.Herba Hyperici Japonici selects the dry herb of Garcinia maingayii Herba Hyperici Japonici Hypericum japonicum Thunb. exMurray.Radix Cissi hexangularis selects the dry rattan of Vitaceae Cissus plant Radix Cissi hexangularis Cissus hexangularis Thorel ex Planch..Fructus Tribuli selects the dry mature fruit of zygophyllaceae plant Fructus Tribuli Tribulus terrestris L..Folium Mori select the dried leaves of moraceae plants Mulberry Morus alba L..Herba Artemisiae Anomalae selects the dry herb of the wounded in the battle Artemisia anomala S. Moore of feverfew artemisia anomalas.HEIQIANNIU selects the dry root of pinkwort gland flower Herba Melandrii Aprici Silene adenantha Franch..Folium Eriobotryae selects the dried leaves of rosaceous plant Folium Eriobotryae Eriobotrya japonica (Thunb.) Lindl..Herba Taraxaci selects the dry herb of feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz..

Further preferably, the externally-applied medicinal composition for the treatment of chloasma as mentioned above, it is prepared to external preparation, comprises lotion, liniment, gel, ointment, ointment.The various dosage forms of pharmaceutical composition of the present invention can be prepared according to the conventional production process of pharmaceutical field.Such as make active component mix with one or more carriers, be then made into required dosage form.

Compared with prior art, the externally-applied medicinal composition that the present invention relates to has warm promoting blood circulation, skin-active blood stasis dispelling, blood-nourishing and freckle-removing, and effect of moist skin, effectively can expand peripheral vessel, improve facial microcirculation, horny layer softening, have certain inhibitory action to pigmentation.Meanwhile, if can be aided with local by comforting, the manual massage such as kneading, point kowtow, Acupressure, further impel blood circulation, improve facial muscle elasticity, relax skin aging speed, accelerate absorption and the dissipation of mottle.

Detailed description of the invention

Be below the specific embodiment that the present invention relates to, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.

The preparation of embodiment 1 Chinese medicine extract medicated powder

Take Herba Salviae Chinensis 0.35kg, Calyx Seu Fructus Physalis 0.15kg, Herba Hyperici Japonici 0.35kg, Radix Cissi hexangularis 0.35kg, Fructus Tribuli 0.15kg, Folium Mori 0.15kg, Herba Artemisiae Anomalae 0.09kg, HEIQIANNIU 0.15kg, Folium Eriobotryae 0.15kg and Herba Taraxaci 0.12kg, then the purified water of medical material gross weight 12 times is added, heating decocts 2h, filter, collect filtrate; The purified water adding medical material weight 10 times amount again in medicinal residues decocts 1.5h, filters, and collects filtrate, twice filtrate is merged, is concentrated into semi-solid extractum, by extractum lyophilization, pulverized 120 mesh sieves, and obtained medicated powder.

Embodiment 2 face mask of traditional Chinese medicine is to the effectiveness study of patient with chloasma

Through being diagnosed as patient 52 example of women's chloasma, be divided into treatment group 26 example at random, wherein 29 ~ 52 years old age, average (47.9 ± 6.2) year, average course of disease (6.4 ± 3.7) year; Matched group 26 example, wherein 30 ~ 52 years old age, average (48.2 ± 5.8) year, average course of disease (7.1 ± 3.5) year.Through statistics, two groups of cases comparing difference not statistically significant in age, the course of disease, severity scale, has comparability.

Treatment group: get 3g medicated powder (preparing by the formulation and technology of embodiment 1) in container, add a small amount of pure water and reconcile into dense dense and burned, adds a little Mel and mixes thoroughly and apply facial film, applies 30 minutes afterwash, the next day 1 time.Matched group: adopt 2% Hydrochinone Cream emulsifiable paste (trade name: thousand is white, and Guangdong Renren Kang Pharmaceutical Co., Ltd produces), every bu is each affected part of exterior coating sooner or later.Two groups of equal treatment and nursing 1 month.By following standard rating curative effect after treatment:

Cure: skin lesion disappears, facial skin is in normal or close to normal skin tone;

Effective: skin lesion disappear more than 70% or speckle color obviously turn shallow, the colour of skin is close to normal;

Effective: skin lesion disappears 30% ~ 70%, speckle complexion changed is shallow;

Invalid: before and after treatment, skin lesion is unchanged, or disappears less than 30%.

The comparitive study of two groups of different pharmaceutical treatment chloasma is in Table l.Can be found out by the test statistics result of table 1, matched group cures 1 example, effective 9 examples, effective 10 examples, invalid 6 examples, and total effective rate is 76.9%; And treatment group cures 5 examples, effective 12 examples, effective 8 examples, invalid 1 example, total effective rate is 96.2%.Obviously, the curative effect for the treatment of group is obviously better than matched group.

Table 1 liang group curative effect statistical result is compared (n=26)

Group	Cure	Effective	Effectively	Invalid	Total effective rate
						Matched group	1	9	10	6	76.9%
Treatment group	5	12	8	1	96.2%

Claims

1. treat an externally-applied medicinal composition for chloasma, it is characterized in that: described compositions is prepared from through water extraction by the traditional Chinese medicinal material raw materials comprising following weight portion: Herba Salviae Chinensis 30-42 part, Calyx Seu Fructus Physalis 11-20 part, Herba Hyperici Japonici 30-42 part, Radix Cissi hexangularis 30-42 part, Fructus Tribuli 11-20 part, Folium Mori 11-20 part, Herba Artemisiae Anomalae 6-12 part, HEIQIANNIU 11-20 part, Folium Eriobotryae 11-20 part, Herba Taraxaci 9-15 part.

2. treat the externally-applied medicinal composition of chloasma as claimed in claim 1, it is characterized in that: described compositions is prepared from through water extraction by the traditional Chinese medicinal material raw materials of following weight portion: Herba Salviae Chinensis 34-37 part, Calyx Seu Fructus Physalis 14-16 part, Herba Hyperici Japonici 34-37 part, Radix Cissi hexangularis 34-37 part, Fructus Tribuli 14-16 part, Folium Mori 14-16 part, Herba Artemisiae Anomalae 8-10 part, HEIQIANNIU 14-16 part, Folium Eriobotryae 14-16 part, Herba Taraxaci 11-13 part.

3. treat the externally-applied medicinal composition of chloasma as claimed in claim 2, it is characterized in that: described compositions is prepared from through water extraction by the traditional Chinese medicinal material raw materials of following weight portion: Herba Salviae Chinensis 35 parts, Calyx Seu Fructus Physalis 15 parts, Herba Hyperici Japonici 35 parts, Radix Cissi hexangularis 35 parts, Fructus Tribuli 15 parts, 15 parts, Folium Mori, Herba Artemisiae Anomalae 9 parts, HEIQIANNIU 15 parts, Folium Eriobotryae 15 parts, Herba Taraxaci 12 parts.

4. as described in claim 1 or 2 or 3, treat the externally-applied medicinal composition of chloasma, it is characterized in that: described compositions is external preparation, comprise lotion, liniment, gel, ointment, ointment.