CN104783919A - Brain tissue damage experimental facility - Google Patents
Brain tissue damage experimental facility Download PDFInfo
- Publication number
- CN104783919A CN104783919A CN201510214318.4A CN201510214318A CN104783919A CN 104783919 A CN104783919 A CN 104783919A CN 201510214318 A CN201510214318 A CN 201510214318A CN 104783919 A CN104783919 A CN 104783919A
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- CN
- China
- Prior art keywords
- guide pipe
- shape
- hole
- blade
- interior pin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a brain tissue damage experimental facility which comprises a guide tube of a hollow tube shape. A matched inner needle is arranged in the guide tube. The upper end of the inner needle is fixedly connected with a rotary device, the lower end of the inner needle is provided with a blade for cutting, the bottom of the guide tube is an arc-shaped curved surface, a through hole through which the lower end of the inner needle penetrates is formed in the arc-shaped curved surface, and the through hole is matched with the blade in shape. In the experimental animal cranial nerve tissue damage process, a mechanical damage mode is adopted, operation is simple, the application range is wide, and accuracy is high. Meanwhile, the near cranial nerve tissue cannot be damaged.
Description
Technical field
The present invention relates to a kind of animal scientific experiment equipment and instrument field, be specifically related to a kind of cerebral tissue damage experimental provision.
Background technology
In order to test cerebral neural effect, in the biological Experiment of Zoology of medical science and nerve, often adopting selectivity to damage the cranial nerve tissue of a certain position, and then with electricity irritation, observing and recording the reaction of cerebral tissue.Contrast by damaging forward and backward function reacting condition to zoopery mesencephalic tissue, the Different Effects that the cranial nerve tissue analyzing diverse location further reacts, the profoundness disclosing cerebral tissue of development.
In prior art, two kinds are roughly divided into the method for cerebral tissue damage: 1, utilize syringe chemical damage agent to be expelled in the cerebral tissue of experiment body; 2, the mode of electric shock is utilized to damage the cerebral tissue of experiment body.Although above two kinds of methods can damage the cranial nerve tissue of specifying in experiment effectively, these two kinds of methods are all very likely damaged to the tissue on side, not accurately, easily make a big impact to experimental result.
Therefore, design a kind of cerebral tissue damage experimental provision simple to operate, applied widely, that degree of accuracy is high to be extremely necessary.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of cerebral tissue simple to operate, applied widely, that degree of accuracy is high and damage experimental provision.
In order to achieve the above object, the technical scheme that the present invention takes is:
A kind of cerebral tissue damage experimental provision, comprise the guide pipe of hollow tubular, suitable interior pin is provided with in this guide pipe, it is characterized in that: described interior pin upper end is fixedly connected with tumbler, lower end is the blade for cutting, the bottom of described guide pipe is arc-shaped curved surface, this arc-shaped curved surface offers the through hole passed for interior pin lower end, the shape of described through hole and the shape of blade suitable.
In use, only guide pipe need be goed deep into cerebral tissue inside, brain main body fixed by positioner on guide pipe outer wall, by adjusting the tumbler of interior pin upper end, make the blade of interior pin lower end through the through hole on bottom guide pipe, and then the cranial nerve device of assigned address is damaged, ensure that the degree of accuracy of cerebral tissue of the present invention damage experimental provision to a great extent.
For adapting to the damage of diverse location cranial nerve tissue, the shape of the blade of described interior pin lower end is a shape or for crosswise or be rice shape, makes interior pin can accurately damage the cranial nerve tissue of assigned address.
For stability when guarantee operation uses, also comprise positioner, described positioner is periphery and is fixed on guide pipe outer wall, and this positioner is the spacing head of circular umbrella, described spacing head is fixed in brain main body, ensure that guide pipe is not easily shifted when operating.
For increasing the scope of application, described through hole at least offers individual, and this through hole is uniformly distributed on the arc-shaped curved surface bottom guide pipe, guarantees that interior pin can reach the damage operation within the scope of maximum gauge in guide pipe.
Compared with prior art, beneficial effect of the present invention is:
1, adopt the cerebral tissue of mechanical system damage laboratory animal, operation is accurate, the tissue of not easily damaged other positions of brain;
2, by pin in adjustment with bottom syringe on the coordinating of multiple through holes, make can reach the operation within the scope of maximum gauge bottom interior pin;
3, the present invention is simple to operate, applied widely, degree of accuracy is high.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Number in the figure: 1, guide pipe; 11, through hole; 12, spacing head; 2, interior pin; 21, tumbler; 22, blade;
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described.
Cerebral tissue damage experimental provision of the present invention, comprise the guide pipe 1 of hollow tubular, the bottom of described guide pipe 1 is arc-shaped curved surface, this arc-shaped curved surface offers the through hole 11 passed for interior pin 2 lower end to see, suitable interior pin 2 is provided with in this guide pipe 1, described interior pin 2 upper end is fixedly connected with tumbler 21, lower end is the blade 22 for cutting, during use, by adjusting the tumbler of interior pin upper end, make the blade of interior pin lower end through the through hole on bottom guide pipe, and then the cranial nerve device of assigned address is damaged; The shape of the blade 22 of described interior pin 2 lower end is a shape or for crosswise or be rice shape, multiple shape is the damage adapting to diverse location cranial nerve tissue, makes interior pin can accurately damage the cranial nerve tissue of assigned address; The shape of described through hole 11 and the shape of blade 22 suitable, described through hole 11 at least offers 2, this through hole 11 is uniformly distributed on the arc-shaped curved surface bottom guide pipe 1, guarantees that interior pin can reach the damage operation within the scope of maximum gauge in guide pipe, effectively increases the scope of application; In addition, also comprise positioner, described positioner is periphery and is fixed on guide pipe 1 outer wall, this positioner is spacing 12 of circular umbrella, ensure that guide pipe is not easily shifted when operating, and greatly enhances the precision of damage, as shown in Figure 1.
It should be pointed out that above case is only the representational example of the present invention.Obviously, technical scheme of the present invention is not limited to above-described embodiment, can also have many degeneration.
Claims (4)
1. cerebral tissue damage experimental provision, comprise the guide pipe (1) of hollow tubular, suitable interior pin (2) is provided with in this guide pipe (1), it is characterized in that: described interior pin (2) upper end is fixedly connected with tumbler (21), lower end is the blade (22) for cutting, the bottom of described guide pipe (1) is arc-shaped curved surface, this arc-shaped curved surface offers the through hole (11) passed for interior pin (2) lower end, the shape of described through hole (11) and the shape of blade (22) suitable.
2. cerebral tissue according to claim 1 damage experimental provision, is characterized in that: the shape of the blade (22) of described interior pin (2) lower end is a shape or for crosswise or be rice shape.
3. cerebral tissue damage experimental provision according to claim 1, it is characterized in that: also comprise positioner, described positioner is periphery and is fixed on guide pipe (1) outer wall, and this positioner is the spacing head (12) of circular umbrella.
4. the cerebral tissue damage experimental provision according to any one of claims 1 to 3, it is characterized in that: described through hole (11) at least offers 2, this through hole (11) is uniformly distributed on the arc-shaped curved surface of guide pipe (1) bottom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510214318.4A CN104783919A (en) | 2015-04-29 | 2015-04-29 | Brain tissue damage experimental facility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510214318.4A CN104783919A (en) | 2015-04-29 | 2015-04-29 | Brain tissue damage experimental facility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104783919A true CN104783919A (en) | 2015-07-22 |
Family
ID=53549436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510214318.4A Pending CN104783919A (en) | 2015-04-29 | 2015-04-29 | Brain tissue damage experimental facility |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104783919A (en) |
Citations (14)
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|---|---|---|---|---|
| CN1056818A (en) * | 1990-05-18 | 1991-12-11 | 刘德玉 | Puncture probe with multi-porous bulb-headed catheter |
| CN1101538A (en) * | 1993-07-09 | 1995-04-19 | 株式会社日硝 | Trocar Assembly |
| CN1672649A (en) * | 2005-04-16 | 2005-09-28 | 何明利 | Cerebrospinal fluid puncturing drainer |
| CN101912292A (en) * | 2010-08-11 | 2010-12-15 | 冯清亮 | In-vivo puncture and intubation device |
| CN201744055U (en) * | 2010-08-11 | 2011-02-16 | 冯清亮 | In-vivo puncture tube-implanting device |
| CN102068298A (en) * | 2011-02-17 | 2011-05-25 | 浙江省立同德医院 | Diversion tube insertion device |
| CN201977893U (en) * | 2011-01-06 | 2011-09-21 | 清远市人民医院 | Minimally invasive puncture catheterization device for ventriculoperitoneal shunt |
| CN102499739A (en) * | 2011-11-21 | 2012-06-20 | 江苏省人民医院 | Low-temperature intracranial hematoma puncturing trocar |
| CN202365865U (en) * | 2011-12-14 | 2012-08-08 | 王丽 | Multipurpose needle knife |
| CN102631234A (en) * | 2012-04-10 | 2012-08-15 | 中国科学院昆明动物研究所 | Deep cerebral dura mater perforating device |
| CN102652682A (en) * | 2012-04-16 | 2012-09-05 | 中国科学院昆明动物研究所 | Micro brain-tissue sampler |
| CN202619842U (en) * | 2012-04-16 | 2012-12-26 | 中国科学院昆明动物研究所 | Electrode for cerebral electrical lesion |
| WO2014016591A1 (en) * | 2012-07-24 | 2014-01-30 | Renishaw Plc | Neurosurgical apparatus and methods |
| CN204671309U (en) * | 2015-04-29 | 2015-09-30 | 桂林医学院 | Cerebral tissue damage experimental provision |
-
2015
- 2015-04-29 CN CN201510214318.4A patent/CN104783919A/en active Pending
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1056818A (en) * | 1990-05-18 | 1991-12-11 | 刘德玉 | Puncture probe with multi-porous bulb-headed catheter |
| CN1101538A (en) * | 1993-07-09 | 1995-04-19 | 株式会社日硝 | Trocar Assembly |
| CN1672649A (en) * | 2005-04-16 | 2005-09-28 | 何明利 | Cerebrospinal fluid puncturing drainer |
| CN101912292A (en) * | 2010-08-11 | 2010-12-15 | 冯清亮 | In-vivo puncture and intubation device |
| CN201744055U (en) * | 2010-08-11 | 2011-02-16 | 冯清亮 | In-vivo puncture tube-implanting device |
| CN201977893U (en) * | 2011-01-06 | 2011-09-21 | 清远市人民医院 | Minimally invasive puncture catheterization device for ventriculoperitoneal shunt |
| CN102068298A (en) * | 2011-02-17 | 2011-05-25 | 浙江省立同德医院 | Diversion tube insertion device |
| CN102499739A (en) * | 2011-11-21 | 2012-06-20 | 江苏省人民医院 | Low-temperature intracranial hematoma puncturing trocar |
| CN202365865U (en) * | 2011-12-14 | 2012-08-08 | 王丽 | Multipurpose needle knife |
| CN102631234A (en) * | 2012-04-10 | 2012-08-15 | 中国科学院昆明动物研究所 | Deep cerebral dura mater perforating device |
| CN102652682A (en) * | 2012-04-16 | 2012-09-05 | 中国科学院昆明动物研究所 | Micro brain-tissue sampler |
| CN202619842U (en) * | 2012-04-16 | 2012-12-26 | 中国科学院昆明动物研究所 | Electrode for cerebral electrical lesion |
| WO2014016591A1 (en) * | 2012-07-24 | 2014-01-30 | Renishaw Plc | Neurosurgical apparatus and methods |
| CN204671309U (en) * | 2015-04-29 | 2015-09-30 | 桂林医学院 | Cerebral tissue damage experimental provision |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150722 |