CN104771837B - A pile three irradiates the anticancer nucleic neutron knife of seat layout - Google Patents
A pile three irradiates the anticancer nucleic neutron knife of seat layout Download PDFInfo
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- CN104771837B CN104771837B CN201510158668.3A CN201510158668A CN104771837B CN 104771837 B CN104771837 B CN 104771837B CN 201510158668 A CN201510158668 A CN 201510158668A CN 104771837 B CN104771837 B CN 104771837B
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Abstract
The invention belongs to a kind of anticancer nucleic neutron knife, specifically discloses the anticancer nucleic neutron knife that a kind of a pile three irradiates seat layout, is cased with side beryllium tore of reflection outside the reactor core side wall of the neutron knife, reactor core bottom is provided with bottom beryllium reflecting disc；The side of side beryllium tore of reflection is externally provided with left aluminium watt part, and the opposite side of side beryllium tore of reflection is externally provided with right graphite tile part, and left aluminium watt part and right graphite tile part are inserted in lower shell；The immediately horizontal combined beam casing parietal layer of aluminum on the left of lower shell, the casing parietal layer of the lower shell opposite side immediately horizontal thermal neutron post of aluminum, the parietal layer of the casing to connect with lower shell or so is all arc plate shape, and the irradiation seat of difference in functionality is constructed in casing.Vertical epithermal neutron irradiation seat is installed below lower shell bottom plate.The anticancer nucleic neutron knife can irradiate multiple patients after a reactor startup, while also treatment different carcinoma class patient can irradiation up to standard simultaneously.
Description
Technical field
The invention belongs to a kind of anticancer nucleic neutron knife, that is, realize in boron or a kind of gadolinium neutron absorption nuclear reactor for cancer
Component irradiation unit, and in particular to a kind of a pile three irradiates the anticancer nucleic neutron knife of seat layout.
Background technology
By boron neutron capture therapy (BNCT) application study in more than 60 years of various countries' research reactor, form according to therapentic part
Different line classification：
Cortex tumour irradiates (0-1.5cm) --- thermal beam；
Human body superficial part tumour irradiates (1.5-4.5cm) --- cross thermal beam (combined beam)；
Human body deep tumor irradiates (4.5-7.0cm) --- epithermal neutron beam；
In vitro irradiation --- the thermal neutron post of internal organs (part or one integral piece).
In existing BNCT clinics heap, a heap only sets a hot beam or an epithermal neutron beam, although Japan uses heap
A branch of possess three kinds of functions (hot, mixed, superthermal exchange), and Argentina employs superthermal with a branch of dual-purpose design that is mixing, but its is every
Set a kind of function must shutdown regulation beam moderator thickness and (or) cadmium regulating course thickness, and reflected, screen layer
Adjustment, also needs to check the parameter and performance of new beam after setting, and Clinical practice efficiency is low, is suitable only for current singleton examination and controls, it is impossible to be full
Foot customary treatment in the future needs.
At present, the hot beam of domestic prior art neutron source only provides zoopery or the irradiation of superficial part tumour is used, and its is superthermal
The beam intensity of beam is too low, and irradiation time is long needed for treatment.
BNCT routine therapeutic systems, it is as more as possible that a reactor startup not only irradiates number of patients, while also looks after different carcinoma class
Patient can irradiation up to standard simultaneously, the neutron source apparatus in currently available technology can not realize.
The content of the invention
It is an object of the invention to provide a kind of anticancer nucleic neutron knife of a pile three irradiation seat layout, the neutron knife is one
Multiple patients can be irradiated after secondary reactor startup, while also treatment different carcinoma class patient can irradiation up to standard simultaneously.
Realize the technical scheme of the object of the invention：A kind of a pile three irradiates the anticancer nucleic neutron knife of seat layout, the anticancer
Nucleic neutron knife includes reactor core, left aluminium watt part, right graphite tile part, side beryllium tore of reflection, bottom beryllium reflecting disc, horizontal mixing neutron exposure
Seat, horizontal thermal neutron post irradiation seat, vertical epithermal neutron irradiation seat, reactor core side wall are cased with side beryllium tore of reflection, reactor core bottom peace outside
Equipped with bottom beryllium reflecting disc；The side of side beryllium tore of reflection is externally provided with left aluminium watt part, and the opposite side of side beryllium tore of reflection is externally provided with right graphite
Watt part, in left aluminium watt part and right graphite tile part insertion lower shell；The immediately horizontal combined beam casing parietal layer of aluminum on the left of lower shell, under
The cylinder opposite side immediately horizontal thermal neutron post case somatopleure of aluminum, the parietal layer of the casing to connect with lower shell or so is all arc plate
Shape, horizontal mixing neutron exposure seat is provided with the outside of horizontal combined beam casing parietal layer, and level mixing neutron exposure seat is embedded in water
In flat combined beam casing parietal layer, horizontal thermal neutron post irradiation seat is installed on the outside of horizontal thermal neutron post case somatopleure, level is hankered
Sub- post irradiation seat is provided with vertical epithermal neutron irradiation seat in horizontal thermal neutron post case somatopleure below lower shell bottom plate.
Described horizontal mixing neutron exposure seat includes deceleration filter, mixing beam reflector, mixing beam collimator, mixing
The outer collimater of beam, the outer collimater mouth of combined beam, horizontal combined beam casing parietal layer outside are provided with deceleration filter, deceleration filter
Outside mixes the inner side of beam collimator in mixing beam reflector outside, mixes beam collimator in mixing beam reflector
Outside be wrapped with the outer collimater of combined beam, mix at beam collimator outboard end embedded with the outer collimater mouth of combined beam.
Described horizontal mixing neutron exposure seat also includes the first neutron shield device, the second neutron shield device, combined beam γ
Device, the 3rd neutron shield device are shielded, mixes and the second neutron shield device is wrapped with the middle part of beam collimator, the outer collimater of combined beam
For mouth in the outer collimater of combined beam, the outer collimater mouth of combined beam, mixing beam collimator are internally formed level mixing neutron port
Road；The outer collimater of combined beam is wrapped with combined beam gamma shielding device and the 3rd neutron shield device, and combined beam gamma shielding device is positioned at the
On the inside of three neutron shield devices；First neutron shield device is wrapped in outside mixing beam reflector, and the outside of the second neutron shield device
Face is bonded with combined beam gamma shielding device medial surface.
Described deceleration filter is combined by graphite linings, Al layers, MgF2 layers, and mixing beam collimator is hollow bismuth system
The outer collimater mouth of truncated cone collimater, the 3rd neutron shield device and combined beam by mass percent containing LiF 70% poly- second
Alkene is made, and the outer collimator material of combined beam is Pb percentage by weights 80%, Poly percentage by weights 19%, B4C percentage by weights
1% Pb-B-Poly, mixes beam reflector and combined beam gamma shielding device is built into by lead brick, and the first neutron shield device is B4C weight
The B-Poly plates of percentage 10%；Second neutron shield device circle made of the polyethylene board comprising B4C mass percents 10%
Frustum cavity and the graphite block composition being filled within frustum of a cone cavity.
Described horizontal thermal neutron post irradiation seat includes the first neutron moderator, plume reflector, the second neutron moderator,
The first neutron moderator is provided with the outside of horizontal thermal neutron post case somatopleure, plume reflector is provided with the outside of the first neutron moderator,
The second neutron moderator is provided with plume reflector, the second neutron moderator center is provided with plume exposure cavity.
Described horizontal thermal neutron post irradiation seat also includes the between the first neutron moderator and plume reflector
One gamma shielding screen, the second gamma shielding screen in plume exposure cavity, for wrapping up the plume neutron shield device of plume reflector,
Plume gamma shielding device on the outside of plume neutron shield device.
Described the first neutron moderator and the second neutron moderator is assembled by core level graphite block to be formed, the first gamma shielding
Screen, the material of the second gamma shielding screen are bismuth, and plume reflector and plume gamma shielding device are built into by lead brick, plume neutron shield
Device is the B-Poly plates of B4C percentage by weights 10%.
Described vertical epithermal neutron irradiation seat includes the graphite body, the first Cd screens, slowing down mistake arranged from top to bottom
The outer collimater of filter, the 2nd Cd screens, superthermal beam collimator, superthermal beam, the outer collimater mouth of superthermal beam, graphite body top is embedded in
Between horizontal combined beam casing parietal layer and horizontal thermal neutron post case somatopleure.
Described vertical epithermal neutron irradiation seat also includes the superthermal reflector of beam first, the first neutron absorber, superthermal beam
Second reflector, the second neutron absorber, superthermal beam outer collimater, superthermal beam gamma shielding device, the 3rd neutron absorber, slowing down mistake
Filter is wrapped with the superthermal reflector of beam first, and the superthermal reflector of beam first is wrapped with the first neutron absorber；Superthermal Shu Zhun
Straight device top is wrapped with the superthermal reflector of beam second, and the second neutron absorber is wrapped with the middle part of superthermal beam collimator, superthermal
Beam collimator bottom is wrapped with the outer collimater of superthermal beam；The outer collimater top of superthermal beam be wrapped with the 3rd neutron absorber,
Superthermal beam gamma shielding device, superthermal beam gamma shielding device bottom surface are bonded with the 3rd neutron absorber top surface；The outer collimater mouth of superthermal beam is embedding
In collimater and it is located at superthermal beam collimator end outside superthermal beam, the intraoral shape of the outer collimater of superthermal beam collimator, superthermal beam
Into vertical epithermal neutron duct.
Described slowing down filter is sequentially overlapped combination and formed by Al layers, Fluental layers, thick Al layers, Fluental layers,
The mass percent composition of Fluental layers is 69%AlF3, 30%Al, 1%6LiF, superthermal beam collimator are hollow bismuth rounding
Taper type collimater, the outer collimator material of superthermal beam is Pb percentage by weights 80%, Poly percentage by weights 19%, B4C weight
The Pb-B-Poly of percentage 1%, the outer collimater mouth of superthermal beam are made up of the polyethylene of mass percent containing LiF 70%, superthermal beam
First reflector, the second reflector and superthermal beam gamma shielding device are built into by lead brick, and the first neutron absorber is B4C weight percents
B-Poly plates than 10%, the second neutron absorber frustum of a cone made of the polyethylene board of mass percent containing B4C 10% are empty
Chamber and the graphite block composition being filled within frustum of a cone cavity；3rd neutron absorber is by mass percent containing LiF 70%
Polyethylene is made.
The advantageous effects of the present invention are：
(1) anticancer nucleic neutron knife of the invention is based on the characteristics of micro- heap volume is small, power is low, in order to obtain high treatment
Dosage, treatment neutron flux is directly drawn from reactor core, rather than large and medium-sized heap typically by transforming the experiment duct outside reflecting layer
Drawn.The anticancer nucleic neutron knife of the present invention selects to get through the side on reactor core supported underneath loaded concrete stratum in layout
Formula, the space of vertical epithermal neutron irradiation seat is developed, the space of vertical epithermal neutron irradiation seat is installed as ground layer segment
Non- application space, the technique transport operation flow of reactor core is not influenceed, remains the overall general layout using micro- heap as core.
(2) anticancer nucleic neutron knife of the invention is using horizontal mixing neutron exposure seat, horizontal thermal neutron post irradiation seat two
Set horizontal irradiation device is laterally outwardly drawn from shell ring under heap container, has squeezed out the water of corresponding site, main in irradiation unit
Configuration be neutron filtering and slowing material, it is lower than water to the absorbability of neutron, not but not increase reactor core uranium loading amount,
Also save the effect of uranium loading amount.
(3) the part water at left and right sides of the reactor core of anticancer nucleic neutron knife of the invention mixes neutron exposure by level
Seat, horizontal thermal neutron post irradiation seat are substituted, but the corresponding site of lower shell ring front and rear sides is without other items, is still water institute
Account for；Thus on thermal technology, the Natural Circulation heat release to top water can be maintained.
(4) the large area level for surrounding the left and right and underface of reactor core mixes neutron exposure seat, the irradiation of horizontal thermal neutron post
Seat, vertical epithermal neutron irradiation seat also can export section reactor core heat, make its Natural Circulation, free convection and natural heat transfer mechanism
It is substantially achieved guarantee.
(5) horizontal mixing neutron exposure seat, horizontal thermal neutron post irradiate seat, and vertical epithermal neutron irradiation seat surrounds reactor core,
So that reactor core is circumferential, lower to the neutron released, almost 100% illuminated seat is intercepted and captured so that neutron and whole passes through the most
Ji ground is applied to cure patient, improves therapeutic effect.
(6) slowing down filter uses 10.35cm thickness Al layers, 15cm thickness Fluental, 10cm thickness Al in superthermal beam irradiation seat
The slowing down filter of layer, 15cm thickness Fluental compositions, can make superthermal beam exit parameter reach 1.26 × 109n·cm-2·s-1Even if error caused by considering engineering construction, it also can guarantee that superthermal beam meets international standards (1 × 109n·cm-2·s-1)。
(7) the deceleration filter of combined beam irradiation seat, the stronger material of moderating power (graphite) is configured in front end with after
End, moderating power weaker material (Al, MgF2) configuration in centre can effectively raise neutron flux.Select 30cm thickness graphite
Layer, 11cm thickness Al layers, 9cm thickness MgF2The deceleration filter of layer, 13cm thickness graphite composition, both will not because slowing material is long and
Cause neutron flux relatively low, also because slowing material is too short interference background of the fast neutron in soft tissue will not be caused bigger than normal.
The outlet thermal neutron flux and epithermal neutron flux of combined beam are respectively 1.1 × 109n·cm-2·s-1, 5 × 108n·cm-2·s-1。
(8) plume selection use double layer screen, can effectively reduce the γ backgrounds for irradiating intracavitary, and the thermal neutron in plume leads to
Amount up to 1.02 × 1010n·cm2·s-1。
Brief description of the drawings
Fig. 1 is the sectional view for the anticancer nucleic neutron knife that a kind of a pile three provided by the present invention irradiates seat layout；
Fig. 2 is the horizontal mixing neutron for the anticancer nucleic neutron knife that a kind of a pile three provided by the present invention irradiates seat layout
Irradiate the main view profile of seat.
Fig. 3 is the horizontal mixing neutron for the anticancer nucleic neutron knife that a kind of a pile three provided by the present invention irradiates seat layout
Irradiate the top plan view of seat.
Fig. 4 is the horizontal thermal neutron post for the anticancer nucleic neutron knife that a kind of a pile three provided by the present invention irradiates seat layout
Irradiate the main view profile of seat.
Fig. 5 is the horizontal thermal neutron post for the anticancer nucleic neutron knife that a kind of a pile three provided by the present invention irradiates seat layout
Irradiate the top plan view of seat.
Fig. 6 is the vertical epithermal neutron for the anticancer nucleic neutron knife that a kind of a pile three provided by the present invention irradiates seat layout
Irradiate the main view profile of seat.
In figure：1 is side beryllium tore of reflection, and 2 be left aluminium watt part, and 3 be lower shell, and 4 be horizontal combined beam casing parietal layer, and 5 be to subtract
Fast filter, 6 be the first neutron shield device, and 7 be mixing beam reflector, and 8 be mixing beam collimator, and 9 be the second neutron shield device,
10 be combined beam gamma shielding device, and 11 be the 3rd neutron shield device, and 12 be the outer collimater of combined beam, and 13 be the outer collimater of combined beam
Mouthful, 14 be the first neutron moderator, and 15 be the first gamma shielding screen, and 16 be plume reflector, and 17 be the second gamma shielding screen, and 18 be the
Two neutron moderators, 19 be plume neutron shield device, and 20 be plume gamma shielding device, and 21 be graphite body, and 22 be the first cadmium screen,
23 be slowing down filter, and 24 be the second cadmium screen, and 25 be superthermal beam collimator, and 26 be superthermal beam gamma shielding device, and 27 be the 3rd neutron
Absorber, 28 be the outer collimater of superthermal beam, and 29 be the outer collimater mouth of superthermal beam, and 30 be the second neutron absorber, and 31 be superthermal beam
Second reflector, 32 be the first neutron absorber, and 33 be the superthermal reflector of beam first, and 34 be horizontal mixing neutron exposure seat, 35
Seat is irradiated for horizontal thermal neutron post, 36 be that vertical epithermal neutron irradiates seat, and 37 be reactor core, and 38 be bottom beryllium reflecting disc, and 39 be right stone
Black watt part, 40 be horizontal thermal neutron post case somatopleure.
Embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.
As shown in Figure 1 and Figure 4, a kind of a pile three provided by the present invention irradiates the anticancer nucleic neutron knife of seat layout, should
Neutron knife includes reactor core 37, left aluminium watt part 2, right graphite tile part 39, side beryllium tore of reflection 1, bottom beryllium reflecting disc 38, horizontal mixing neutron
Seat 34, horizontal thermal neutron post irradiation seat 35, vertical epithermal neutron irradiation seat 36 are irradiated, side beryllium tore of reflection is cased with outside the side wall of reactor core 37
1, the bottom of reactor core 37 installation bottom beryllium reflecting disc 38；The side of side beryllium tore of reflection 1 is externally provided with the left aluminium watt part 2 of circular arc tubular, side
The opposite side of beryllium tore of reflection 1 is externally provided with the right graphite tile part 39 of circular arc tubular；Stayed between left aluminium watt part 2 and right graphite tile part 39
There is gap, the gap is watering cycle space.Immediately horizontal combined beam casing parietal layer 4 outside the side of lower shell 3, lower shell 3 is another
Side immediately horizontal thermal neutron post case somatopleure 40；The outside of horizontal combined beam casing parietal layer 4 is provided with horizontal mixing neutron exposure
Seat 34, level mixing neutron exposure seat 34 is in horizontal combined beam casing parietal layer 4；The horizontal outside of thermal neutron post case somatopleure 40
Horizontal thermal neutron post irradiation seat 35 is installed, horizontal thermal neutron post irradiation seat 35 is in horizontal thermal neutron post case somatopleure 40.Water
The horizontal center line axis of flat mixing neutron exposure seat 34 overlaps with the horizontal axis of reactor core 37, the water of horizontal thermal neutron post irradiation seat 34
Flat central axis overlaps with the horizontal axis of reactor core 37, and horizontal mixing neutron exposure seat 34, horizontal thermal neutron post irradiation seat 35 with
Line is symmetrical centered on the vertical axis of reactor core 37.The lower section of bottom beryllium reflecting disc 38 is provided with vertical epithermal neutron irradiation seat 36,
The vertical axis of vertical epithermal neutron irradiation seat 36 overlaps with the vertical axis of reactor core 37.
The supported underneath loaded concrete stratum of reactor core 37 is got through, forms the space for installing vertical epithermal neutron irradiation seat 36, and
Exposure cell is set up below vertical epithermal neutron irradiation seat 36.In order to ensure the quality of superthermal beam and index, vertical epithermal neutron
Irradiation seat 36 occupies the space of part of horizontal mixing neutron exposure seat 34 and horizontal thermal neutron column base 35, will it is vertically superthermal in
Son irradiation seat 36 top both sides are respectively in the bottom of horizontal mixing neutron exposure seat 34, the inner side of horizontal thermal neutron column base 35.
As shown in Figure 1, 2, 3, horizontal mixing neutron exposure seat 34 includes deceleration filter 5, the first neutron shield device 6, mixed
Close beam reflector 7, mixing beam collimator 8, the second neutron shield device 9, combined beam gamma shielding device 10, the 3rd neutron shield device 11,
The outer collimater 12 of combined beam, the outer collimater mouth 13 of combined beam, the inner side of deceleration filter 5 are provided with circular arc cylinder, and the circular arc cylinder is tight
The flat combined beam casing parietal layer 4 of water receiving, the outside of deceleration filter 5 is in mixing beam reflector 7, and the one of mixing beam collimator 8
For wing base in the outside of mixing beam reflector 7, the middle part of mixing beam collimator 8 is wrapped with the second neutron shield device 9, mixes
The opposite side of beam collimator 8 is wrapped with the outer collimater 12 of combined beam；In the outer collimater 12 of combined beam, outside mixing beam collimator 8
Embedded with the outer collimater mouth 13 of combined beam at side end.The outer collimater mouth 13 of combined beam, mixing beam collimator 8 are internally formed horizontal mixed
Close neutron beam duct A.The outer collimater 12 of combined beam is wrapped with combined beam gamma shielding device 10 and the 3rd neutron shield device 11, mixes
Beam gamma shielding device 10 is located at the inner side of the 3rd neutron shield device 11.First neutron shield device 6 is wrapped in outside mixing beam reflector 7, the
The lateral surface of two neutron shield devices 9 is bonded with the medial surface of combined beam gamma shielding device 10.
Deceleration filter 5 is sequentially overlapped by 30cm thickness graphite linings, 11cm thickness Al layers, 9cm thickness MgF2 layers, 13cm thickness graphite linings
Combine.
Mixing beam collimator 8 is hollow bismuth rounding taper type collimater, and exit is cylindrical, the outer collimater of combined beam
Mouth 13 is made up of the polyethylene of mass percent containing LiF 70%；The outer material of collimater 12 of combined beam is Pb percentage by weights 80%,
Poly percentage by weights 19%, the Pb-B-Poly of B4C percentage by weights 1%.
Mixing beam reflector 7 and combined beam gamma shielding device 10 are built into by lead brick.
First neutron shield device 6 is the B-Poly plates of B4C percentage by weights 10%；Second neutron shield device 9 includes containing B4C
Frustum of a cone cavity made of the polyethylene board of mass percent 10%, and it is filled in the graphite block within frustum of a cone cavity；The
Three neutron shield devices 11 are made up of the polyethylene of mass percent containing LiF 70%.
As shown in Figure 4,5, horizontal thermal neutron post irradiation seat 35 include the first neutron moderator 14, the first gamma shielding screen 15,
Plume reflector 16, the second gamma shielding screen 17, the second neutron moderator 18, plume neutron shield device 19, plume gamma shielding device 20,
The inner side of first neutron moderator 14 is provided with circular arc cylinder, the circular arc cylinder immediately horizontal thermal neutron post case somatopleure 40.In first
It is bonded between the sub- lateral surface of decelerator 14 and the side external surface of plume reflector 16 1, the first neutron moderator 14 and plume reflector
The first gamma shielding screen 15 is embedded between 16, one end of the first gamma shielding screen 15 is embedded in the groove of the first neutron moderator 14, the
The other end of one gamma shielding screen 15 runs through plume reflector 16.The second neutron moderator 18 is enclosed with plume reflector 16, the
One gamma shielding screen 15 is bonded with the second neutron moderator 18, and the center of the second neutron moderator 18 is provided with plume exposure cavity B, and plume shines
Penetrate side in chamber B and be embedded with the second gamma shielding screen 17.Plume reflector 16 is wrapped with plume neutron shield device 19, plume neutron screen
The lateral surface of device 19 is covered to be bonded with the medial surface of plume gamma shielding device 20.
First neutron moderator 14 and the second neutron moderator 18 are assembled by high-purity core level graphite block to be formed.First gamma shielding
The material for shielding the 15, second gamma shielding screen 17 is bismuth.
Plume reflector 16 and plume gamma shielding device 20 are built into by lead brick.
Plume neutron shield device 19 is the B-Poly plates of B4C percentage by weights 10%.
As shown in fig. 6, vertical epithermal neutron irradiation seat 36 includes the graphite body 21, first arranged from top to bottom successively
The outer collimater 28 of Cd screens 22, slowing down filter 23, the 2nd Cd screens 24, superthermal beam collimator 25, superthermal beam, the outer collimater of superthermal beam
Mouth 29, the top of graphite body 21 are embedded between horizontal combined beam casing parietal layer 4, horizontal thermal neutron post case somatopleure 40.Graphite
The bottom surface of slow body 21 is bonded with the top surface of the first Cd screens 22, and the bottom surface of the first Cd screens 22 is bonded with the top surface of slowing down filter 23, slowing down mistake
Filter 23 is wrapped with superthermal the first reflector of beam 33, and superthermal the first reflector of beam 33 is wrapped with the first neutron absorber 32.
The superthermal bottom surface of the first reflector of beam 33, the bottom surface of the first neutron absorber 32 are bonded with the top surface of the 2nd Cd screens 24, the 2nd Cd screens 24
Bottom surface is bonded with the superthermal top surface of beam collimator 25.The superthermal top of beam collimator 25 is wrapped with superthermal the second reflector of beam 31, surpasses
The hot middle part of beam collimator 25 is wrapped with the second neutron absorber 30, and it is outer accurate that the superthermal bottom of beam collimator 25 is wrapped with superthermal beam
Straight device 28.The outer top of collimater 28 of superthermal beam is wrapped with the 3rd neutron absorber 27, superthermal beam gamma shielding device 26, superthermal beam γ
The shielding bottom surface of device 26 is bonded with the top surface of the 3rd neutron absorber 27；In the outer collimater 28 of superthermal beam, the superthermal end of beam collimator 25
Place is embedded with the outer collimater mouth 29 of superthermal beam.Vertical epithermal neutron is formed in the outer collimater mouth 29 of superthermal beam collimator 25, superthermal beam
Duct C.
Slowing down filter 23 is thick by 10.35cm thickness Al layers, 15cm thickness Fluental layers, 10cm thickness Al layers, 15cm
Fluental layers are sequentially overlapped combination composition.Wherein, Fluental mass percent composition is 69%AlF3, 30%Al, 1%6LiF。
Superthermal beam collimator 25 is hollow bismuth rounding taper type collimater, and exit is cylinder；Collimated outside superthermal beam
The material of device 28 is Pb percentage by weights 80%, Poly percentage by weights 19%, the Pb-B-Poly of B4C percentage by weights 1%；It is super
The outer collimater mouth 29 of hot beam is made up of the polyethylene of mass percent containing LiF 70%.
Superthermal beam the first reflector 33, the second reflector 31 and superthermal beam gamma shielding device 26 are built into by lead brick.
First neutron absorber 32 is the B-Poly plates of B4C percentage by weights 10%；Second neutron absorber 30 includes containing
Frustum of a cone cavity made of the polyethylene board of B4C mass percents 10%, and it is filled in the graphite block within frustum of a cone cavity；
3rd neutron absorber 27 is made up of the polyethylene of mass percent containing LiF 70%.
Below in conjunction with the accompanying drawings 1 to 6, a kind of description a pile three provided by the present invention irradiates the anticancer nucleic neutron of seat layout
The course of work of knife：
After reactor start-up, the neutron that reactor core 37 leaks out, by bottom beryllium reflecting disc 38, is surpassed by vertical direction into vertical
Thermal neutron irradiates seat 36, successively by graphite body 21, the first Cd screens 22, slowing down filter 23, the 2nd Cd screens 24, superthermal beam
The deceleration of the outer collimater 28 of collimater 25, superthermal beam, slowing down, collimater mouth 29 draws epithermal neutron beam outside superthermal beam.Reactor core
37 neutrons leaked out are by horizontal direction by side beryllium tore of reflection 1, left aluminium watt part 2, lower shell 3, horizontal combined beam casing parietal layer
4, into level mixing neutron exposure seat 34, successively by deceleration filter 5, mixing beam reflector 7, mixing beam collimator 8
Deceleration slowing down, collimater mouth 13 draws mixing neutron beam outside combined beam.The neutron that reactor core 37 leaks out is another by horizontal direction
Side is by side beryllium tore of reflection 1, left graphite tile part 39, lower shell 3, horizontal thermal neutron post case somatopleure 40, into horizontal thermal neutron
Post irradiates seat 35, successively by the first neutron moderator 14, the first gamma shielding screen 15, plume reflector 16, the second neutron degradation
The deceleration slowing down of device 18, the second gamma shielding screen 17, netron-flux density is up to 1.02 × 10 in plume exposure cavity B10n·
cm2·s-1。
The present invention is explained in detail above in conjunction with drawings and examples, but the present invention is not limited to above-mentioned implementation
Example, in those of ordinary skill in the art's possessed knowledge, can also make on the premise of present inventive concept is not departed from
Go out various change.The content not being described in detail in the present invention can use prior art.
Claims (8)
1. a kind of a pile three irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：The neutron knife includes reactor core (37), a left side
Aluminium watt part (2), right graphite tile part (39), side beryllium tore of reflection (1), bottom beryllium reflecting disc (38), horizontal mixing neutron exposure seat (34),
Horizontal thermal neutron post irradiation seat (35), vertical epithermal neutron irradiation seat (36), reactor core (37) side wall are cased with side beryllium tore of reflection outside
(1), reactor core (37) bottom is provided with bottom beryllium reflecting disc (38)；The side of side beryllium tore of reflection (1) is externally provided with left aluminium watt part (2), side
The opposite side of beryllium tore of reflection (1) is externally provided with right graphite tile part (39), left aluminium watt part (2) and right graphite tile part (39) insertion lower shell
(3)；Outer immediately horizontal combined beam casing parietal layer (4) on the left of lower shell (3), immediately horizontal thermal neutron outside lower shell (3) opposite side
Post case somatopleure (40)；The parietal layer of the casing to connect with lower shell or so is all arc plate shape；Horizontal combined beam casing parietal layer (4)
Outside is provided with horizontal mixing neutron exposure seat (34), and level mixing neutron exposure seat (34) is embedded in horizontal combined beam casing parietal layer
(4) in, horizontal thermal neutron post irradiation seat (35) is installed on the outside of horizontal thermal neutron post case somatopleure (40), horizontal thermal neutron post shines
Seat (35) is penetrated in horizontal thermal neutron post case somatopleure (40), vertical epithermal neutron is installed below lower shell (3) bottom plate and shone
Penetrate seat (36)；Deceleration filter (5) is combined by graphite linings, Al layers, MgF2 layers；Described horizontal thermal neutron post irradiation seat
(35) the first neutron moderator (14), plume reflector (16), the second neutron moderator (18), horizontal thermal neutron post case body are included
The first neutron moderator (14) is provided with the outside of parietal layer (40), plume reflector (16) is provided with the outside of the first neutron moderator (14),
The second neutron moderator (18) is provided with plume reflector (16), the second neutron moderator (18) center is provided with plume exposure cavity
(B)；Described horizontal thermal neutron post irradiation seat (35) is also included positioned at the first neutron moderator (14) and plume reflector (16)
Between the first gamma shielding screen (15), the second gamma shielding screen (17) in plume exposure cavity (B), for wrap up plume reflection
The plume neutron shield device (19) of device (16), the plume gamma shielding device (20) on the outside of plume neutron shield device (19)；Slowing down
Filter (23) is sequentially overlapped combination and formed by Al layers, Fluental layers, thick Al layers, 1Fluental layers, the matter of Fluental layers
It is 69%AlF to measure percentage composition3, 30%Al, 1%6LiF。
2. a kind of a pile three according to claim 1 irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：It is described
Horizontal mixing neutron exposure seat (34) include deceleration filter (5), mixing beam reflector (7), mixing beam collimator (8), mixed
The outer collimater (12) of beam, the outer collimater mouth (13) of combined beam are closed, deceleration filter is provided with the outside of horizontal combined beam casing parietal layer (4)
(5), in mixing beam reflector (7), the inner side of mixing beam collimator (8) is embedded in combined beam in the outside of deceleration filter (5)
In on the outside of reflector (7), mix and the outer collimater (12) of combined beam is wrapped with the outside of beam collimator (8), mix beam collimator
(8) embedded with the outer collimater mouth (13) of combined beam at outboard end.
3. a kind of a pile three according to claim 2 irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：It is described
Horizontal mixing neutron exposure seat (34) also include the first neutron shield device (6), the second neutron shield device (9), combined beam γ screens
Device (10), the 3rd neutron shield device (11) are covered, the second neutron shield device (9) is wrapped with the middle part of mixing beam collimator (8), is mixed
Close the outer collimater mouth (13) of beam to be located in the outer collimater (12) of combined beam, the outer collimater mouth (13) of combined beam, mixing beam collimator
(8) it is internally formed horizontal mixing neutron beam duct (A)；The outer collimater (12) of combined beam is wrapped with combined beam gamma shielding device (10)
With the 3rd neutron shield device (11), combined beam gamma shielding device (10) is located on the inside of the 3rd neutron shield device (11)；First neutron screen
Cover device (6) and be wrapped in mixing beam reflector (7) outside, and the lateral surface of the second neutron shield device (9) and combined beam gamma shielding device
(10) medial surface is bonded.
4. a kind of a pile three according to claim 3 irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：It is described
Mixing beam collimator (8) be hollow bismuth rounding taper type collimater, collimated outside the 3rd neutron shield device (11) and combined beam
Device mouth (13) is made by the polyethylene of mass percent containing LiF 70%, and outer collimater (12) material of combined beam is Pb weight hundred
Divide than 80%, Poly percentage by weights 19%, the Pb-B-Poly of B4C percentage by weights 1%, mixing beam reflector (7) and mixing
Beam gamma shielding device (10) is built into by lead brick, and the first neutron shield device (6) is the B-Poly plates of B4C percentage by weights 10%；Second
Neutron shield device (9) frustum of a cone cavity and is filled in circle made of the polyethylene board comprising B4C mass percents 10%
Graphite block composition within frustum cavity.
5. a kind of a pile three according to claim 4 irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：It is described
The first neutron moderator (14) and the second neutron moderator (18) assembled and formed by core level graphite block, the first gamma shielding screen
(15), (17) material of the second gamma shielding screen is bismuth, and plume reflector (16) and plume gamma shielding device (20) are built by lead brick
Into plume neutron shield device (19) is the B-Poly plates of B4C percentage by weights 10%.
6. a kind of a pile three according to claim 5 irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：It is described
Vertical epithermal neutron irradiation seat (36) include arrange from top to bottom graphite body (21), the first Cd screens (22), slowing down mistake
The outer collimater (28) of filter (23), the 2nd Cd screens (24), superthermal beam collimator (25), superthermal beam, the outer collimater mouth of superthermal beam
(29), at the top of graphite body (21) embedded in horizontal combined beam casing parietal layer (4), horizontal thermal neutron post case somatopleure (40) it
Between.
7. a kind of a pile three according to claim 6 irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：It is described
Vertical epithermal neutron irradiation seat (36) also include the superthermal reflector of beam first (33), the first neutron absorber (32), superthermal beam
Second reflector (31), the second neutron absorber (30), superthermal beam outer collimater (28), superthermal beam gamma shielding device (26), the 3rd
Neutron absorber (27), slowing down filter (23) are wrapped with the superthermal reflector of beam first (33), the superthermal reflector of beam first
(33) it is wrapped with the first neutron absorber (32)；Superthermal beam collimator (25) top is wrapped with the superthermal reflector of beam second
(31) the second neutron absorber (30), superthermal beam collimator (25) bottom outsourcing, are wrapped with the middle part of superthermal beam collimator (25)
It is wrapped with the outer collimater (28) of superthermal beam；Outer collimater (28) top of superthermal beam is wrapped with the 3rd neutron absorber (27), superthermal
Beam gamma shielding device (26), superthermal beam gamma shielding device (26) bottom surface are bonded with the 3rd neutron absorber (27) top surface；Superthermal beam is outer accurate
Straight device mouth (29) is interior embedded in the outer collimater (28) of superthermal beam and is located at superthermal beam collimator (25) end, superthermal beam collimator
(25), vertical epithermal neutron duct (C) is formed in the outer collimater mouth (29) of superthermal beam.
8. a kind of a pile three according to claim 7 irradiates the anticancer nucleic neutron knife of seat layout, it is characterised in that：It is described
Superthermal beam collimator (25) be hollow bismuth rounding taper type collimater, outer collimater (28) material of superthermal beam is Pb weight hundred
Divide than 80%, Poly percentage by weights 19%, the Pb-B-Poly of B4C percentage by weights 1%, the outer collimater mouth (29) of superthermal beam
It is made up of the polyethylene of mass percent containing LiF 70%, the superthermal reflector of beam first (33), the second reflector (31) and superthermal beam
Gamma shielding device (26) is built into by lead brick, the first neutron absorber (32) be B4C percentage by weights 10% B-Poly plates, second
Neutron absorber (30) frustum of a cone cavity and is filled in circular cone made of the polyethylene board of mass percent containing B4C 10%
Graphite block composition within platform cavity；3rd neutron absorber (27) is made up of the polyethylene of mass percent containing LiF 70%.
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| CN108295385B (en) * | 2017-01-11 | 2024-04-16 | 南京中硼联康医疗科技有限公司 | Neutron capture therapeutic device |
| WO2020211581A1 (en) * | 2019-04-17 | 2020-10-22 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy system |
| CN111821580A (en) * | 2019-04-17 | 2020-10-27 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy system and beam shaper for neutron capture therapy system |
| AU2020260204B2 (en) | 2019-04-17 | 2023-10-12 | Neuboron Therapy System Ltd. | Neutron capture therapy system |
| CN116913573B (en) * | 2023-08-01 | 2024-01-23 | 烟台大学 | Neutron beam-gathering device |
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| CN1509777A (en) * | 2002-12-25 | 2004-07-07 | 周永茂 | Neutron radiating device in hospital |
| JP4596392B2 (en) * | 2006-03-08 | 2010-12-08 | 三菱重工業株式会社 | Neutron generator and neutron irradiation system |
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