CN104771766A - Contrast medium for myocardial perfusion imaging and preparation method - Google Patents
Contrast medium for myocardial perfusion imaging and preparation method Download PDFInfo
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Abstract
The invention discloses a contrast medium for myocardial perfusion imaging. The contrast medium is prepared through principal raw materials which comprise, by weight, 2-4 parts of roots of tomentoseflower larkspour, 4-6 parts of finelydivided phtheirospermum, 3-7 parts of polygonum orientale, 1-5 parts of ageratum conyzoides, 1-5 parts of mother-of-pearls, 1-5 parts of endothelium corneum gigeriae galli, 5-9 parts of sedum aizoon, 3-8 parts of coral dealbatus, 10-20 parts of corn, 2-6 parts of radix angelicae pubescentis, 3-9 parts of poria cocos, 10-20 parts of poria with hostwood, 6-12 parts of glossy ganoderma, 5-10 parts of lotus plumule, 2-3 parts of black bamboo roots, 4-7 parts of radix astragali and 5-15 parts of amber. The contrast medium has no toxic effects or side effects and is convenient to use and stable in physical and chemical property, comparison is obvious, images are clear, traditional Chinese medicine formulas are reasonably combined, injury of conventional contrast media to intestinal tracts is avoided, and the oral contrast medium is applied to conventional gastrointestinal tract preparation and special examination.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to contrast agent and the preparation method of myocardial perfusion imaging.
Background technology
Myocardial perfusion imaging judges coronary heart disease, myocardial infarction area, and the monitoring of coronary artery bypass and thromboembolism treatment, is prefered method.Heart muscle perfusion SPEVT checks can provide myocardium transverse section, coronalplane and sagittal layer image.(1) diagnosing cardiac infarction or ishemic part, size and scope.(2) Differential Diagnosis of abnormal Q wave ECG.
Along with the development of Chinese Chinese medicine; in myocardial perfusion imaging; the extract that people appreciate Chinese medicine gradually coordinates the material being easy to video picture again; be prepared into the obvious contrast agent of video picture; bear painful little advantage, and Chinese traditional treatment great attention to whole idea, pay attention to comprehensive control; pay attention to protection body, the contrast agent of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
Summary of the invention
For the deficiencies in the prior art; an object of the present invention is to provide a kind of contrast agent for myocardial perfusion imaging, and image definition, contrast are obviously, rational performance stablizes, and can provide protective effect to gastrointestinal tract simultaneously; routine and special examination ultrasonic contrast, to human body without any injury.
Another object of the present invention is just to provide the preparation method of above-mentioned contrast agent.
Technical scheme of the present invention is:
The contrast agent of myocardial perfusion imaging, takes off the primary raw material stating weight proportion and is prepared from:
Rhizoma Arisaematis 2-4 part Phtheirospermum tenuisectum Bur.et Franch. 4-6 part Herba Polygoni Orientalis 3-7 part
Herba Agerati Conyzoidis 1-5 part Concha Margaritifera 1-5 part Endothelium Corneum Gigeriae Galli 1-5 part
Herba Sedi Aizoon 5-9 part Herba Sedi Aizoon 3-8 part Semen Maydis 10-20 part
Radix Angelicae Pubescentis 2-6 part Poria 3-9 part Poria cum Radix Pini 10-20 part
Ganoderma 6-12 part Plumula Nelumbinis 5-10 part Rhizoma phyllostachydis nigrae 2-3 part
Radix Astragali 4-7 part succinum 5-15 part.
The contrast agent of myocardial perfusion imaging, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from:
Rhizoma Arisaematis 2.5-3.5 part Phtheirospermum tenuisectum Bur.et Franch. 4.5-5.5 part Herba Polygoni Orientalis 4-6 part
Herba Agerati Conyzoidis 2-4 part Concha Margaritifera 2-4 part Endothelium Corneum Gigeriae Galli 2-4 part
Herba Sedi Aizoon 6-8 part Herba Sedi Aizoon 5-7 part Semen Maydis 13-18 part
Radix Angelicae Pubescentis 3-5 part Poria 5-7 part Poria cum Radix Pini 13-18 part
Ganoderma 8-10 part Plumula Nelumbinis 6-9 part Rhizoma phyllostachydis nigrae 2.3-2.8 part
Radix Astragali 5-6 part succinum 8-13 part.
The contrast agent of myocardial perfusion imaging, more preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from:
Rhizoma Arisaematis 3 parts of Phtheirospermum tenuisectum Bur.et Franch.s 5 portions of Herba Polygoni Orientaliss 5 parts
Herba Agerati Conyzoidis 3 parts of Concha Margaritiferas 3 parts of Endothelium Corneum Gigeriae Galli 3 parts
Herba Sedi Aizoon 7 parts of Herba Sedi Aizoon 6 parts of Semen Maydiss 15 parts
Radix Angelicae Pubescentis 4 parts of Poria 6 parts of Poria cum Radix Pinis 15 parts
Ganoderma 9 parts of Plumula Nelumbiniss 8 parts of Rhizoma phyllostachydis nigraes 2.5 parts
The Radix Astragali 5.5 parts of succinums 10 parts.
The preparation method of above-mentioned contrast agent, step is as follows:
(1) cleaned up by Concha Margaritifera, with soaking in rice vinegar 2-4 hour, be exposed to the sun under being placed in daylight 3-5 days (preferably 4 days), smash to pieces and grind to form fine powder, cross 120-160 mesh sieve stand-by;
(2) Herba Agerati Conyzoidis, Radix Angelicae Pubescentis, the Radix Astragali and succinum are cut into slices, dried, mix thoroughly with yellow wine, stewing 20-40 hour, be placed in the hot pot that dryouies, fry 2-6 minute, put to grinding at room temperature and become smalls stand-by;
(3) Semen Maydis is eluriated 3 times, add Semen Maydis weight 5-10 water doubly, big fire decocts after 10-20 minute and puts into Phtheirospermum tenuisectum Bur.et Franch. block and Herba Polygoni Orientalis block, continues to boil 10-30 minute, and filter, filtrate is for subsequent use, and filtering residue is smashed to pieces, is placed in microwave oven and bakes 3-7 minute, takes out stand-by;
(4) cleaned by Endothelium Corneum Gigeriae Galli, with orange peel water soaking 20-40 minute, dryouied by hot pot, rapidly drop into soaked Endothelium Corneum Gigeriae Galli, fry to crisp, it is stand-by to grind to form smalls;
(5) Rhizoma Arisaematis, Herba Sedi Aizoon, Herba Sedi Aizoon, Poria, Poria cum Radix Pini, Ganoderma, Plumula Nelumbinis and Rhizoma phyllostachydis nigrae are ground, crossing 80-120 mesh sieve is placed in step (3) gained filtrate, decoct while stir, after 5-10 to be mixed minute (preferably 8 minutes), add step (1)-(4) gains, little fire simmers 30-50 minute slowly, sealing and standing 3-5 hour, supernatant is placed in clean container and is heated to 50 DEG C, put into arabic gum and the silicon oil foam killer of supernatant volume 1/5, after arabic gum and silicon oil foam killer melt completely, cool bottling and get final product.
The preparation method of above-mentioned contrast agent, step (1) is with soaking in rice vinegar 2.5-3.5 hour (preferred, with soaking in rice vinegar 3 hours).
The preparation method of above-mentioned contrast agent, step (1) fine powder crosses 130-150 mesh sieve stand-by (preferred, it is stand-by that fine powder crosses 140 mesh sieves).
The preparation method of above-mentioned contrast agent, step (2) boils in a covered pot over a slow fire 25-35 hour, is placed in the hot pot that dryouies, fries 3-5 minute (preferred, stewing 30 hours, to be placed in the hot pot that dryouies, to fry 4 minutes).
The preparation method of above-mentioned contrast agent, step (3) adds Semen Maydis weight 6-9 water doubly (preferred, to add the water of Semen Maydis weight 7.5 times).
The preparation method of above-mentioned contrast agent, step (3) filtering residue is smashed to pieces, is placed in microwave oven and bakes 4-6 minute (preferred, filtering residue is smashed to pieces, is placed in microwave oven roasting 5 minutes).
The preparation method of above-mentioned contrast agent, step (4) is with orange peel water soaking 25-35 minute (preferred, with orange peel water soaking 30 minutes).
The pharmacological effect of each crude drug is respectively:
Rhizoma Arisaematis: Rhizoma Arisaematis: base is former: for Bryaceae rhodobryum spp plant warms up the plant of ground great Ye moss.Composition: plant contains volatile oil, flavonoid, steroidal, aminoacid, saccharide, glycoside, terpenoid etc.The property of medicine: pungent, bitter, flat.Function cures mainly: tranquilizing by nourishing the heart, liver heat removing and eyesight improving.Cure mainly severe palpitation, neurasthenia, conjunctival congestion and swelling pain, coronary heart disease etc.
Phtheirospermum tenuisectum Bur.et Franch.: base is former: be the herb of Scrophulariaceae Phtheirospermum plant Phtheirospermum tenuisectum Bur.et Franch..The property of medicine: pungent, micro-hardship, flat.Function cures mainly: dissipating blood stasis detoxifies, tranquilizing by nourishing the heart.Cure mainly fracture to swell and ache, cough, sputum mixed with blood, laryngopharynx swelling and pain, myocardium palpitation with a distress feeling, Serpentis lyssodexis.
Herba Polygoni Orientalis: be the stem and leaf of Polygonaceae arsesmart Polygonum knotweed.Pharmacology: have the effect increasing myocardial alimentary blood flow, have the effect of anti-acute myocardial ischemia, have remarkable effect to Cardiovarscular, have the effect of anti-inflammation, can uteri excitation be stimulated.The property of medicine: pungent, flat, mild toxicity.Return liver.Spleen channel.Function cures mainly: expelling wind and removing dampness.Heat-clearing and toxic substances removing.Invigorate blood circulation.
Herba Agerati Conyzoidis: be the herb of Compositae Ageratum plant Ageratum conyzoides.Composition: herb contains flavonoid, alkaloid, triterpenoid compound, volatile oil.Aerial parts I have chromene class.Pharmacology: have stimulation to cardiac muscle, has inhibitory action to smooth muscle, has the effect of anti-inflammatory and antalgic, has antibacterial effect.The property of medicine: micro-hardship, pungent, cool.Function cures mainly: heat-clearing and toxic substances removing, hemostasis, pain relieving.
Concha Margaritifera: another name: pearl Paeonia suffruticosa, pearl oyster, natural pearls are female, jewel is female, concha Anodonta seu Cristaria.Effect: suppressing the hyperactive liver and subsiding YANG, calm the nerves, improving eyesight of calming the frightened.Concoct: pick decontamination, knock fragment, sieve dedust bits, suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, hemostasis.Control dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis, metrorrhagia.
Endothelium Corneum Gigeriae Galli: sweet is flat.Gui Jing returns spleen, stomach, small intestinal, urinary bladder channel.Effect invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil.Cure mainly and do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain.
Herba Sedi Aizoon: Herba Sedi Aizoon main disease to be treated has heart disease, apoplexy, hypertension, hyperlipidemia, consumptive disease, haematemesis, hemoptysis, traumatic injury etc.All have diseases such as middle-aged and elderly people sclerosis of blood vessels hyperlipidemia, hypertension and well alleviate and therapeutical effect.
Herba Sedi Aizoon: Herba hylotelephii erythrosticti is sweet, the acid of paddy steroid oleanolic acid, acetone, flavone, several amino acids and vitamin, the flat sweet in the mouth of its property, there is blood circulation promoting and blood stasis dispelling, the suppressing the hyperactive liver that nourishes heart, calm the nerves enrich blood, effect of heat-clearing and toxic substances removing, be common broad-spectrum green herbal medicine among the people, former plant is also one of antitumor Chinese herbal medicine.Verify through expert clinical: the edible Herba Sedi Aizoon several months can suppress and treat hypertensive heart disease (coronary heart disease, arrhythmia, paroxysmal tachycardia, rheumatic heart disease etc.), have mind calming suppressing the hyperactive liver, calm the nerves enrich blood, the effect of heat-clearing and toxic substances removing, hemostasia and dissipation blood stasis, can prevent and treat that hysteria, arteriosclerosis, apoplectic hemiplegia, insomnia and dreamful sleep, cardiopalmus are nervous, more than the ten kind of cardiovascular and cerebrovascular disease such as hyperlipidemia, diabetes, thrombocytopenic purpura, gingival hemorrhage, menorrhagia, traumatic injury, hepatitis, digestive tract hemorrhage, therefore named Herba Sedi Aizoon.
Semen Maydis: Semen Maydis is the health-care good product in coarse grain, rather favourable to the health of human body: the compositions such as the vitamin B6 in Semen Maydis, nicotinic acid, there is stimulating gastrointestinal and wriggle, accelerate the characteristic of defecate, can prevent treating constipation, gastropathy, enteritis, intestinal cancer etc.Semen Maydis is rich in vitamin C, dextrinosan etc., has longevity, beautification function.Nutrient substance contained by corn germ point has enhancing human metabolism, adjustment nervous function.Can play and make skin delicacy smooth, suppress, delay wrinkle generation effect.Semen Maydis to have in tune effect of appetizing and blood fat reducing, reduction serum cholesterol.It is relevant with their main edible corn that hypertension is not easily suffered from by Central America American Indian.
Poria: sweet in the mouth, light, property is put down.Return through GUIXIN, lung, spleen, kidney channel.Effect promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Cure mainly for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix Angelicae Pubescentis: be the root of the heavy tooth Radix Angelicae Sinensis of Umbelliferae archangel.Composition: containing coumarin kind compound, volatile oil, acetas, angelol, thymol.Pharmacology: play a very important role to cardiovascular system, has the effect of blood pressure lowering, can promote hematoblastic gathering, have good analgesia and antiinflammatory action.There is anti-light quick effect, have significant curative effect to opposing tumor, anti-inflammation is also played a very important role.The property of medicine: bitter, tepor, pungent.Return kidney, urinary bladder channel.Function cures mainly: expelling wind and dampness, dispersing cold for relieving pain.
Poria cum Radix Pini: medicinal effects is the white portion entertaining Radix Pini massonianae in the middle of dry sclerotia body.Nature and flavor are sweet, light flat.There are the functions such as eliminating dampness by diuresis, spleen invigorating, mind calming.For phlegm retention, edema, dysuria, have loose bowels, cardiopalmus, dizzy.
Ganoderma: main containing aminoacid, polypeptide, protein, fungal lysozyme (fungal lysozyme), and saccharide (reducing sugar and polysaccharide), ergosterol, triterpenes, coumarin glycoside, volatile oil, stearic acid, benzoic acid, alkaloid, vitamin B2 and C etc.; Spore, also containing mannitol, trehalose (trehalose), has effect for the treatment of infantile dyspepsia, relieving cough and asthma, for dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.Zoopery and clinical trial all show, Ganoderma Rhizoma Arisaematis can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is protective effect, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.To high fat of blood patient, Rhizoma Arisaematis can obviously reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, then there are reduction Arterial Cholesterol content, vessel softening, prevent the effect of damage further.Malaise, insomnia, palpitation with fear.This product sweet in the mouth is put down, and enters heart channel, can reinforcing the heart blood, the beneficial motive, tranquilizing mind, therefore availablely controls the disease such as malaise caused by insufficiency of vital energy and blood, lack of preservation of spirit, insomnia, palpitation with fear, dreaminess, forgetful, the tired Mental fatigue of body, lack of appetite.
Plumula Nelumbinis: containing liensinine, isoliensinine, (-)-Neferine, nuciferine, pronuciferine (+)-Pronuciferine, lotusin, methyl-corypalline, demethyl coclaurine.Again containing flavonoids such as cistus grass glycoside, hyperin, globulariacitrins.Plumula Nelumbinis tea have clear away heart-fire reduce phlegm and internal heat, arresting seminal emission, stop blooding, the effect such as to quench the thirst, heart failure, shock, sexual impotence, vexed, thirsty, haematemesis, seminal emission, conjunctival congestion can be treated, the disease such as swell and ache, clearing away heart-fire, suppressing the hyperactive liver fire, lung-fire, falls in purgation of spleen excess fire, relieve summer heat relieving restlessness, promoting the production of body fluid to quench thirst, controls order redness.Drink with embryo nelumbinis bath, can constipation be treated.Have Historical Data Data About, lotus seed core tea is concocted with Folium Nelumbinis dewdrop always in the every Summer Villa of Emperor Qianlong, with the heart nourishing and intellengence improving, and adjustment vigour, clearing away heart-fire and removing toxic substances.Embryo nelumbinis taste is extremely bitter, but has significant cardiotonic, can expand peripheral blood vessel, reduce blood pressure.Plumula Nelumbinis well goes effect of heart-fire in addition, can treat aphtha of the mouth and tongue, and conduce to sleep.
Rhizoma phyllostachydis nigrae: pungent; Light; Cool, function cures mainly expelling wind and removing dampness; Promoting blood circulation and detoxication.Main air damp-heat arthralgia; Muscles and bones is ached; Amenorrhea; Lump in the abdomen; Lyssodexis.
The Radix Astragali: the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, infusing drugs in wine, enter dish etc.
Succinum: be the resin of Pinaceae pine genus plant in ancient times, is imbedded in the fossil sample material that underground is transformed year in year out for a long time.Composition: mainly resinous, volatile oil, diabietionlic acid, succinosilvic acid, amber tree fat acid, succinoabietol, succinic acid, Borneolum Syntheticum etc.The property of medicine: sweet, flat.GUIXIN, liver, urinary bladder channel.Function cures mainly: tranquillizing the mind by relieving convulsion, and dissipating blood stasis stops blooding, relieving stranguria by diuresis, nebula of dispelling improving eyesight.Cure mainly insomnia, palpitation with fear, infantile convulsion, epilepsy, congestion amenorrhea, puerperal abdonimal pain ， lumps in the chest and abdomen, stranguria with blood hematuria, the raw cataracta of order.Compatibility and incompatibility of drugs: yin asthenia generating intrinsic heat and without the careful clothes of the stagnant person of the stasis of blood.
The present invention has no side effect, easy to use, and physicochemical property is stablized, and contrast is obvious, image definition, simultaneously reasonably combined
Chinese prescription, avoids the damage of conventional contrast agents to intestinal, be applicable to conventional gastrointestinal road prepare and the oral of special examination make
Shadow agent.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the contrast agent of myocardial perfusion imaging, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part):
Rhizoma Arisaematis 2 parts of Phtheirospermum tenuisectum Bur.et Franch.s 4 portions of Herba Polygoni Orientaliss 3 parts
Herba Agerati Conyzoidis 1 part of Concha Margaritifera 1 part of Endothelium Corneum Gigeriae Galli 1 part
Herba Sedi Aizoon 5 parts of Herba Sedi Aizoon 3 parts of Semen Maydiss 10 parts
Radix Angelicae Pubescentis 2 parts of Poria 3 parts of Poria cum Radix Pinis 10 parts
Ganoderma 6 parts of Plumula Nelumbiniss 5 parts of Rhizoma phyllostachydis nigraes 2 parts
The Radix Astragali 4 parts of succinums 5 parts.
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Concha Margaritifera is cleaned up, with soaking in rice vinegar 2 hours, be exposed to the sun under being placed in daylight 3 days, smash to pieces and grind to form fine powder, cross 120 mesh sieves stand-by;
(2) Herba Agerati Conyzoidis, Radix Angelicae Pubescentis, the Radix Astragali and succinum are cut into slices, dried, mix thoroughly with yellow wine, stewing 20 hours, be placed in the hot pot that dryouies, fry 2 minutes, put to grinding at room temperature and become smalls stand-by;
(3) Semen Maydis is eluriated 3 times, add the water of Semen Maydis weight 5 times, Phtheirospermum tenuisectum Bur.et Franch. block and Herba Polygoni Orientalis block are put in big fire after decocting 10 minutes, continue to boil 10 minutes, and filter, filtrate is for subsequent use, and filtering residue is smashed to pieces, are placed in microwave oven roasting 3 minutes, take out stand-by;
(4) cleaned by Endothelium Corneum Gigeriae Galli, with orange peel water soaking 20 minutes, dryouied by hot pot, drop into soaked Endothelium Corneum Gigeriae Galli rapidly, fry to crisp, it is stand-by to grind to form smalls;
(5) Rhizoma Arisaematis, Herba Sedi Aizoon, Herba Sedi Aizoon, Poria, Poria cum Radix Pini, Ganoderma, Plumula Nelumbinis and Rhizoma phyllostachydis nigrae are ground, crossing 80 mesh sieves is placed in step (3) gained filtrate, decoct while stir, after 5 minutes to be mixed, add step (1)-(4) gains, little fire simmers 30 minutes slowly, sealing and standing 3 hours, supernatant is placed in clean container and is heated to 50 DEG C, put into arabic gum and the silicon oil foam killer of supernatant volume 1/5, after arabic gum and silicon oil foam killer melt completely, cool bottling and get final product.
embodiment 2the contrast agent of myocardial perfusion imaging, takes off the primary raw material stating weight proportion and is prepared from (getting 5g for every part):
Rhizoma Arisaematis 4 parts of Phtheirospermum tenuisectum Bur.et Franch.s 6 portions of Herba Polygoni Orientaliss 7 parts
Herba Agerati Conyzoidis 5 parts of Concha Margaritiferas 5 parts of Endothelium Corneum Gigeriae Galli 5 parts
Herba Sedi Aizoon 9 parts of Herba Sedi Aizoon 8 parts of Semen Maydiss 20 parts
Radix Angelicae Pubescentis 6 parts of Poria 9 parts of Poria cum Radix Pinis 20 parts
Ganoderma 12 parts of Plumula Nelumbiniss 10 parts of Rhizoma phyllostachydis nigraes 3 parts
The Radix Astragali 7 parts of succinums 15 parts.
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Concha Margaritifera is cleaned up, with soaking in rice vinegar 4 hours, be exposed to the sun under being placed in daylight 5 days, smash to pieces and grind to form fine powder, cross 160 mesh sieves stand-by;
(2) Herba Agerati Conyzoidis, Radix Angelicae Pubescentis, the Radix Astragali and succinum are cut into slices, dried, mix thoroughly with yellow wine, stewing 40 hours, be placed in the hot pot that dryouies, fry 6 minutes, put to grinding at room temperature and become smalls stand-by;
(3) Semen Maydis is eluriated 3 times, add the water of Semen Maydis weight 10 times, Phtheirospermum tenuisectum Bur.et Franch. block and Herba Polygoni Orientalis block are put in big fire after decocting 20 minutes, continue to boil 30 minutes, and filter, filtrate is for subsequent use, and filtering residue is smashed to pieces, are placed in microwave oven roasting 7 minutes, take out stand-by;
(4) cleaned by Endothelium Corneum Gigeriae Galli, with orange peel water soaking 40 minutes, dryouied by hot pot, drop into soaked Endothelium Corneum Gigeriae Galli rapidly, fry to crisp, it is stand-by to grind to form smalls;
(5) Rhizoma Arisaematis, Herba Sedi Aizoon, Herba Sedi Aizoon, Poria, Poria cum Radix Pini, Ganoderma, Plumula Nelumbinis and Rhizoma phyllostachydis nigrae are ground, crossing 120 mesh sieves is placed in step (3) gained filtrate, decoct while stir, after 10 minutes to be mixed, add step (1)-(4) gains, little fire simmers 50 minutes slowly, sealing and standing 5 hours, supernatant is placed in clean container and is heated to 50 DEG C, put into arabic gum and the silicon oil foam killer of supernatant volume 1/5, after arabic gum and silicon oil foam killer melt completely, cool bottling and get final product.
embodiment 3the contrast agent of myocardial perfusion imaging, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part):
Rhizoma Arisaematis 2.5 parts of Phtheirospermum tenuisectum Bur.et Franch.s 4.5 portions of Herba Polygoni Orientaliss 4 parts
Herba Agerati Conyzoidis 2 parts of Concha Margaritiferas 2 parts of Endothelium Corneum Gigeriae Galli 2 parts
Herba Sedi Aizoon 6 parts of Herba Sedi Aizoon 5 parts of Semen Maydiss 13 parts
Radix Angelicae Pubescentis 3 parts of Poria 5 parts of Poria cum Radix Pinis 13 parts
Ganoderma 8 parts of Plumula Nelumbiniss 6 parts of Rhizoma phyllostachydis nigraes 2.3 parts
The Radix Astragali 5 parts of succinums 8 parts.
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Concha Margaritifera is cleaned up, with soaking in rice vinegar 2.5 hours, be exposed to the sun under being placed in daylight 3 days, smash to pieces and grind to form fine powder, cross 130 mesh sieves stand-by;
(2) Herba Agerati Conyzoidis, Radix Angelicae Pubescentis, the Radix Astragali and succinum are cut into slices, dried, mix thoroughly with yellow wine, stewing 25 hours, be placed in the hot pot that dryouies, fry 3 minutes, put to grinding at room temperature and become smalls stand-by;
(3) Semen Maydis is eluriated 3 times, add the water of Semen Maydis weight 6 times, Phtheirospermum tenuisectum Bur.et Franch. block and Herba Polygoni Orientalis block are put in big fire after decocting 13 minutes, continue to boil 15 minutes, and filter, filtrate is for subsequent use, and filtering residue is smashed to pieces, are placed in microwave oven roasting 4 minutes, take out stand-by;
(4) cleaned by Endothelium Corneum Gigeriae Galli, with orange peel water soaking 25 minutes, dryouied by hot pot, drop into soaked Endothelium Corneum Gigeriae Galli rapidly, fry to crisp, it is stand-by to grind to form smalls;
(5) Rhizoma Arisaematis, Herba Sedi Aizoon, Herba Sedi Aizoon, Poria, Poria cum Radix Pini, Ganoderma, Plumula Nelumbinis and Rhizoma phyllostachydis nigrae are ground, crossing 90 mesh sieves is placed in step (3) gained filtrate, decoct while stir, after 6 minutes to be mixed, add step (1)-(4) gains, little fire simmers 35 minutes slowly, sealing and standing 3.5 hours, supernatant is placed in clean container and is heated to 50 DEG C, put into arabic gum and the silicon oil foam killer of supernatant volume 1/5, after arabic gum and silicon oil foam killer melt completely, cool bottling and get final product.
embodiment 4the contrast agent of myocardial perfusion imaging, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part):
Rhizoma Arisaematis 3.5 parts of Phtheirospermum tenuisectum Bur.et Franch.s 5.5 portions of Herba Polygoni Orientaliss 6 parts
Herba Agerati Conyzoidis 4 parts of Concha Margaritiferas 4 parts of Endothelium Corneum Gigeriae Galli 4 parts
Herba Sedi Aizoon 8 parts of Herba Sedi Aizoon 7 parts of Semen Maydiss 18 parts
Radix Angelicae Pubescentis 5 parts of Poria 7 parts of Poria cum Radix Pinis 18 parts
Ganoderma 10 parts of Plumula Nelumbiniss 9 parts of Rhizoma phyllostachydis nigraes 2.8 parts
The Radix Astragali 6 parts of succinums 13 parts.
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Concha Margaritifera is cleaned up, with soaking in rice vinegar 2-4 hour, be exposed to the sun under being placed in daylight 5 days, smash to pieces and grind to form fine powder, cross 150 mesh sieves stand-by;
(2) Herba Agerati Conyzoidis, Radix Angelicae Pubescentis, the Radix Astragali and succinum are cut into slices, dried, mix thoroughly with yellow wine, stewing 35 hours, be placed in the hot pot that dryouies, fry 5 minutes, put to grinding at room temperature and become smalls stand-by;
(3) Semen Maydis is eluriated 3 times, add the water of Semen Maydis weight 9 times, Phtheirospermum tenuisectum Bur.et Franch. block and Herba Polygoni Orientalis block are put in big fire after decocting 18 minutes, continue to boil 25 minutes, and filter, filtrate is for subsequent use, and filtering residue is smashed to pieces, are placed in microwave oven roasting 6 minutes, take out stand-by;
(4) cleaned by Endothelium Corneum Gigeriae Galli, with orange peel water soaking 35 minutes, dryouied by hot pot, drop into soaked Endothelium Corneum Gigeriae Galli rapidly, fry to crisp, it is stand-by to grind to form smalls;
(5) Rhizoma Arisaematis, Herba Sedi Aizoon, Herba Sedi Aizoon, Poria, Poria cum Radix Pini, Ganoderma, Plumula Nelumbinis and Rhizoma phyllostachydis nigrae are ground, crossing 110 mesh sieves is placed in step (3) gained filtrate, decoct while stir, after 9 minutes to be mixed, add step (1)-(4) gains, little fire simmers 45 minutes slowly, sealing and standing 4.5 hours, supernatant is placed in clean container and is heated to 50 DEG C, put into arabic gum and the silicon oil foam killer of supernatant volume 1/5, after arabic gum and silicon oil foam killer melt completely, cool bottling and get final product.
embodiment 5the contrast agent of myocardial perfusion imaging, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part):
Rhizoma Arisaematis 3 parts of Phtheirospermum tenuisectum Bur.et Franch.s 5 portions of Herba Polygoni Orientaliss 5 parts
Herba Agerati Conyzoidis 3 parts of Concha Margaritiferas 3 parts of Endothelium Corneum Gigeriae Galli 3 parts
Herba Sedi Aizoon 7 parts of Herba Sedi Aizoon 6 parts of Semen Maydiss 15 parts
Radix Angelicae Pubescentis 4 parts of Poria 6 parts of Poria cum Radix Pinis 15 parts
Ganoderma 9 parts of Plumula Nelumbiniss 8 parts of Rhizoma phyllostachydis nigraes 2.5 parts
The Radix Astragali 5.5 parts of succinums 10 parts.
The preparation method of above-mentioned contrast agent, preparation process is as follows:
(1) Concha Margaritifera is cleaned up, with soaking in rice vinegar 3 hours, be exposed to the sun under being placed in daylight 4 days, smash to pieces and grind to form fine powder, cross 140 mesh sieves stand-by;
(2) Herba Agerati Conyzoidis, Radix Angelicae Pubescentis, the Radix Astragali and succinum are cut into slices, dried, mix thoroughly with yellow wine, stewing 30 hours, be placed in the hot pot that dryouies, fry 4 minutes, put to grinding at room temperature and become smalls stand-by;
(3) Semen Maydis is eluriated 3 times, add the water of Semen Maydis weight 7.5 times, Phtheirospermum tenuisectum Bur.et Franch. block and Herba Polygoni Orientalis block are put in big fire after decocting 15 minutes, continue to boil 20 minutes, and filter, filtrate is for subsequent use, and filtering residue is smashed to pieces, are placed in microwave oven roasting 5 minutes, take out stand-by;
(4) cleaned by Endothelium Corneum Gigeriae Galli, with orange peel water soaking 30 minutes, dryouied by hot pot, drop into soaked Endothelium Corneum Gigeriae Galli rapidly, fry to crisp, it is stand-by to grind to form smalls;
(5) Rhizoma Arisaematis, Herba Sedi Aizoon, Herba Sedi Aizoon, Poria, Poria cum Radix Pini, Ganoderma, Plumula Nelumbinis and Rhizoma phyllostachydis nigrae are ground, crossing 100 mesh sieves is placed in step (3) gained filtrate, decoct while stir, after 8 minutes to be mixed, add step (1)-(4) gains, little fire simmers 40 minutes slowly, sealing and standing 4 hours, supernatant is placed in clean container and is heated to 50 DEG C, put into arabic gum and the silicon oil foam killer of supernatant volume 1/5, after arabic gum and silicon oil foam killer melt completely, cool bottling and get final product.
Claims (10)
1. the contrast agent of myocardial perfusion imaging, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
Rhizoma Arisaematis 2-4 part Phtheirospermum tenuisectum Bur.et Franch. 4-6 part Herba Polygoni Orientalis 3-7 part
Herba Agerati Conyzoidis 1-5 part Concha Margaritifera 1-5 part Endothelium Corneum Gigeriae Galli 1-5 part
Herba Sedi Aizoon 5-9 part Herba Sedi Aizoon 3-8 part Semen Maydis 10-20 part
Radix Angelicae Pubescentis 2-6 part Poria 3-9 part Poria cum Radix Pini 10-20 part
Ganoderma 6-12 part Plumula Nelumbinis 5-10 part Rhizoma phyllostachydis nigrae 2-3 part
Radix Astragali 4-7 part succinum 5-15 part.
2. the contrast agent of myocardial perfusion imaging according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
Rhizoma Arisaematis 2.5-3.5 part Phtheirospermum tenuisectum Bur.et Franch. 4.5-5.5 part Herba Polygoni Orientalis 4-6 part
Herba Agerati Conyzoidis 2-4 part Concha Margaritifera 2-4 part Endothelium Corneum Gigeriae Galli 2-4 part
Herba Sedi Aizoon 6-8 part Herba Sedi Aizoon 5-7 part Semen Maydis 13-18 part
Radix Angelicae Pubescentis 3-5 part Poria 5-7 part Poria cum Radix Pini 13-18 part
Ganoderma 8-10 part Plumula Nelumbinis 6-9 part Rhizoma phyllostachydis nigrae 2.3-2.8 part
Radix Astragali 5-6 part succinum 8-13 part.
3. the contrast agent of myocardial perfusion imaging according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
Rhizoma Arisaematis 3 parts of Phtheirospermum tenuisectum Bur.et Franch.s 5 portions of Herba Polygoni Orientaliss 5 parts
Herba Agerati Conyzoidis 3 parts of Concha Margaritiferas 3 parts of Endothelium Corneum Gigeriae Galli 3 parts
Herba Sedi Aizoon 7 parts of Herba Sedi Aizoon 6 parts of Semen Maydiss 15 parts
Radix Angelicae Pubescentis 4 parts of Poria 6 parts of Poria cum Radix Pinis 15 parts
Ganoderma 9 parts of Plumula Nelumbiniss 8 parts of Rhizoma phyllostachydis nigraes 2.5 parts
The Radix Astragali 5.5 parts of succinums 10 parts.
4. the preparation method of the contrast agent of the myocardial perfusion imaging according to any one of claim 1-3, is characterized in that: step is as follows:
(1) cleaned up by Concha Margaritifera, with soaking in rice vinegar 2-4 hour, be exposed to the sun under being placed in daylight 3-5 days (preferably 4 days), smash to pieces and grind to form fine powder, cross 120-160 mesh sieve stand-by;
(2) Herba Agerati Conyzoidis, Radix Angelicae Pubescentis, the Radix Astragali and succinum are cut into slices, dried, mix thoroughly with yellow wine, stewing 20-40 hour, be placed in the hot pot that dryouies, fry 2-6 minute, put to grinding at room temperature and become smalls stand-by;
(3) Semen Maydis is eluriated 3 times, add Semen Maydis weight 5-10 water doubly, big fire decocts after 10-20 minute and puts into Phtheirospermum tenuisectum Bur.et Franch. block and Herba Polygoni Orientalis block, continues to boil 10-30 minute, and filter, filtrate is for subsequent use, and filtering residue is smashed to pieces, is placed in microwave oven and bakes 3-7 minute, takes out stand-by;
(4) cleaned by Endothelium Corneum Gigeriae Galli, with orange peel water soaking 20-40 minute, dryouied by hot pot, rapidly drop into soaked Endothelium Corneum Gigeriae Galli, fry to crisp, it is stand-by to grind to form smalls;
(5) Rhizoma Arisaematis, Herba Sedi Aizoon, Herba Sedi Aizoon, Poria, Poria cum Radix Pini, Ganoderma, Plumula Nelumbinis and Rhizoma phyllostachydis nigrae are ground, crossing 80-120 mesh sieve is placed in step (3) gained filtrate, decoct while stir, after 5-10 to be mixed minute (preferably 8 minutes), add step (1)-(4) gains, little fire simmers 30-50 minute slowly, sealing and standing 3-5 hour, supernatant is placed in clean container and is heated to 50 DEG C, put into arabic gum and the silicon oil foam killer of supernatant volume 1/5, after arabic gum and silicon oil foam killer melt completely, cool bottling and get final product.
5. the preparation method of contrast agent according to claim 4, is characterized in that: step (1) is with soaking in rice vinegar 2.5-3.5 hour (preferred, with soaking in rice vinegar 3 hours).
6. the preparation method of contrast agent according to claim 4, is characterized in that: step (1) fine powder crosses 130-150 mesh sieve stand-by (preferred, it is stand-by that fine powder crosses 140 mesh sieves).
7. the preparation method of contrast agent according to claim 4, is characterized in that: step (2) boils in a covered pot over a slow fire 25-35 hour, is placed in the hot pot that dryouies, fries 3-5 minute (preferred, stewing 30 hours, to be placed in the hot pot that dryouies, to fry 4 minutes).
8. the preparation method of contrast agent according to claim 4, is characterized in that: step (3) adds Semen Maydis weight 6-9 water doubly (preferred, to add the water of Semen Maydis weight 7.5 times).
9. the preparation method of contrast agent according to claim 4, is characterized in that: step (3) filtering residue is smashed to pieces, is placed in microwave oven and bakes 4-6 minute (preferred, filtering residue is smashed to pieces, is placed in microwave oven roasting 5 minutes).
10. the preparation method of contrast agent according to claim 4, is characterized in that: step (4) is with orange peel water soaking 25-35 minute (preferred, with orange peel water soaking 30 minutes).
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| CN101843908A (en) * | 2004-04-28 | 2010-09-29 | 布里斯托尔-迈尔斯斯奎布药品公司 | The contrast agent of myocardial perfusion imaging |
| CN103041410A (en) * | 2013-01-03 | 2013-04-17 | 王国宝 | Contrast powder for gastrointestinal ultrasonic diagnosis |
| CN104189923A (en) * | 2014-09-05 | 2014-12-10 | 李晓光 | Gastrointestinal contrast agent and preparation method thereof |
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2015
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| CN101843908A (en) * | 2004-04-28 | 2010-09-29 | 布里斯托尔-迈尔斯斯奎布药品公司 | The contrast agent of myocardial perfusion imaging |
| CN103041410A (en) * | 2013-01-03 | 2013-04-17 | 王国宝 | Contrast powder for gastrointestinal ultrasonic diagnosis |
| CN104189923A (en) * | 2014-09-05 | 2014-12-10 | 李晓光 | Gastrointestinal contrast agent and preparation method thereof |
| CN104524192A (en) * | 2015-01-09 | 2015-04-22 | 毕少杰 | Heart-nourishing dredging capsule for preventing myocardial infarction and preparation method thereof |
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Application publication date: 20150715 |