CN104758271A - Plant vacant capsule compounded from cellulose gum and red alga KAPPA gum and preparation method thereof - Google Patents
Plant vacant capsule compounded from cellulose gum and red alga KAPPA gum and preparation method thereof Download PDFInfo
- Publication number
- CN104758271A CN104758271A CN201510113319.XA CN201510113319A CN104758271A CN 104758271 A CN104758271 A CN 104758271A CN 201510113319 A CN201510113319 A CN 201510113319A CN 104758271 A CN104758271 A CN 104758271A
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- Prior art keywords
- glue
- red algae
- gum
- cellulose gum
- capsule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a plant vacant capsule compounded from cellulose gum and red alga KAPPA gum and a preparation method thereof. The plant vacant capsule includes following components, by weight: 88-90% of a compounded gum of cellulose gum and red alga KAPPA gum, 1-3% of potassium chloride, 0-0.2% of a sulfite, 3-5% of medicinal glycerin and 2-3% of titanium dioxide. The compounded gum of cellulose gum and red alga KAPPA gum is a mixture composed of carboxymethyl cellulose salt SCMC, hydroxypropyl methyl cellulose HPMC and the red alga KAPPA gum according to the weight ratio of 8:80:12. The plant vacant capsule compounded from the cellulose gum and the red alga KAPPA gum is quick in disintegration speed and is good in film forming property and storage stability.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind ofly adopt plant hollow capsule of cellulose gum and the composite manufacture of red algae card handkerchief glue and preparation method thereof.
Background technology
Capsule is formally classified as medicine adjuvant by country, is widely used in hospital field.With the medicine of capsule dress, be all generally to esophagus and gastric mucosa powder excitatory or granule, or mouthfeel bad, be easy to volatilization, easily decomposed by saliva in the oral cavity, and easily suck the medicine of trachea.These medicines incapsulate, and have both protected the medicine property of medicine and have not been destroyed, also protected digestive organs and respiratory tract.Capsule divides according to raw material, and capsule generally comprises gelatine capsule and plant capsule.Most of capsules of current use are made up of gelatin, and its main material is zoogenous gelatin.Adopt animal raw material to make gelatine capsule, add a large amount of chemical analysis in its process, it also can use a large amount of water resources in process of production, produces serious pollution to air and water environment.Meanwhile, because animal is present in certain disease probability, the therefore great potential safety hazard of existence of capsule that obtains of animal gelatin.
Compare with gelatine capsule, the advantage of rhodophyta capsule is: water content is low, is applicable to very much the filling of the medicine of hygroscopicity by force with to moisture-sensitive.Have the suitability wide, without cross-linking reaction risk and the high advantage of stability; Rhodophyta capsule not easily grows microorganism, preservative free; Rhodophyta capsule friability hardly under low moisture conditions, under high temperature, capsule shells character is still stablized.
At present existing numerous patent application about plant hard capsule, but obviously there is the slow defect of disintegration rate in its plant capsule provided, simultaneously the film property of its plant gum utricule and storage-stable poor, harmful effect is existed to some drugs in capsule.
Summary of the invention
For above problem, patent object of the present invention is to devise and a kind ofly adopts plant hollow capsule of cellulose gum and the composite manufacture of red algae card handkerchief glue and preparation method thereof, and its disintegration rate is fast, film property and storage-stable good.
Adopt a plant hollow capsule for cellulose gum and the composite manufacture of red algae card handkerchief glue, comprise the composition of following percentage by weight:
Cellulose gum and red algae card handkerchief glue compound gel 88 ~ 90%, potassium chloride 1 ~ 3%, sulphite 0 ~ 0.2%, medicinal glycerin 3 ~ 5%, titanium dioxide 2 ~ 3%;
Described cellulose gum and red algae card handkerchief glue compound gel are carboxymethyl cellulose salt SCMC, hydroxypropyl emthylcellulose HPMC and red algae card handkerchief glue mix by weight the ratio for 8:80:12.
Further, red algae card handkerchief glue of the present invention is red algae KAPPA glue.
The present invention also provides the preparation method of the plant hollow capsule of a kind of cellulose gum and the composite manufacture of red algae card handkerchief glue, comprises the steps:
Steps A, is mixed into cellulose gum and red algae card handkerchief glue compound gel by carboxymethyl cellulose salt SCMC, hydroxypropyl emthylcellulose HPMC and red algae card handkerchief glue by weight the ratio for 8:80:12;
Step B, by weight percentage, take cellulose gum and the red algae card handkerchief glue compound gel of 88 ~ 90%, add distilled water, under rapid mixing conditions, the described cellulose gum of slow interpolation and red algae card handkerchief glue compound gel, mix and blend 10 minutes, then moves in interlayer steam cooker, be heated to 88 DEG C, and fully stir, 30 minutes response time, make it dissolve uniformly glue;
Step C, adds the potassium chloride of 1 ~ 3%, the sulphite of 0 ~ 0.2% by weight percentage successively, the medicinal glycerin of 3 ~ 5%, the titanium dioxide of 2 ~ 3%, and stir, glue temperature is down to 50 DEG C, continues insulated and stirred l ~ 2 hour, formed and dip in gum forming solution;
Step D, prepares capsule blank with capsule die mode dunking method, more prepared capsule blank is carried out dried, and baking temperature remains on 30 ~ 35 DEG C, 1 ~ 2 hour drying time, namely obtains the plant hollow capsule be shaped after finally carrying out the demoulding.
Further, red algae card handkerchief glue of the present invention is red algae KAPPA glue.
Specific embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Red algae KAPPA glue is a kind of water soluble polysaccharide extracted from red algae, there is the characteristics such as thickening, gel and film forming, particularly when cellulose gum and red algae KAPPA glue composite time cooperative effect best, tenacity and the elasticity of capsule can be increased, therefore, one of red algae KAPPA glue important raw materials for production just becoming vegetable glue softgel shell.
The favourable aspect of hydroxypropyl emthylcellulose HPMC is used to be: intensity, the flexibility of HPMC are all very stable, substantially without hygroscopic effect.HPMC has the characteristics such as applicable water solublity, heat setting colloidality, thickening property, film property and emulsibility.Its main chemical property swellingly in cold water then to be dissolved, and then forming gel when temperature reaches more than 50 DEG C, is the excipient of most heat stability.
The present invention adopts cellulose gum and red algae KAPPA glue compound gel to be primary raw material, prepares plant hollow capsule.Study moulding process and the manufacture method of capsule simultaneously, find out the succedaneum that a kind of gelatine capsule is new: the plant hollow capsule being raw material with cellulose gum and red algae KAPPA glue compound gel.
The present invention proposes the preparation method of the plant hollow capsule of a kind of cellulose gum and the composite manufacture of red algae card handkerchief glue, comprise the steps:
1, carboxymethyl cellulose salt SCMC, hydroxypropyl emthylcellulose HPMC and red algae card handkerchief glue are mixed into cellulose gum and red algae card handkerchief glue compound gel by weight the ratio for 8:80:12;
2, by weight percentage, take cellulose gum and the red algae card handkerchief glue compound gel of 88 ~ 90%, add distilled water, under rapid mixing conditions, slowly add described cellulose gum and red algae card handkerchief glue compound gel, mix and blend 10 minutes, then move in interlayer steam cooker, be heated to 88 DEG C, and fully stir, in 30 minutes response time, it is made to dissolve uniformly glue;
3, the potassium chloride of 1 ~ 3% is added by weight percentage successively, the sulphite of 0 ~ 0.2%, the medicinal glycerin of 3 ~ 5%, the titanium dioxide of 2 ~ 3%, and stir, glue temperature is down to 50 DEG C, continue insulated and stirred l ~ 2 hour, formed and dip in gum forming solution;
4, prepare capsule blank with capsule die mode dunking method, more prepared capsule blank is carried out dried, baking temperature remains on 30 ~ 35 DEG C, and 1 ~ 2 hour drying time, the final water content of capsule base is 6 ~ 8%;
5, with special capsule pincers, capsule base is pulled up, capsule base capsule cutting machine is cut into the length of regulation;
6, be placed on special workbench by Manufactured Capsules, table top is glass, fills daylight lamp below.This platform checks, rejects defective work, by upper and lower for capsule two joint fits.Splendid attire, in hermetic container, is stored in shady and cool dry place, namely obtains the rhodophyta Capsules be shaped.
After tested, rhodophyta Capsules prepared by the present invention is less than 10 minutes its disintegration, and viscosity (8% solution, in dry product) is greater than 50mpa.s, and sulfite content is (with SO
2meter) be less than 100mg/kg, loss on drying is 4 ~ 10%.
The above the specific embodiment of the present invention, does not form limiting the scope of the present invention.Various other that any technical conceive according to the present invention is made change and distortion accordingly, all should be included in the protection domain of the claims in the present invention.
Claims (4)
1. cellulose gum and the composite plant hollow capsule of red algae card handkerchief glue, is characterized in that, comprise the composition of following percentage by weight:
Cellulose gum and red algae card handkerchief glue compound gel 88 ~ 90%, potassium chloride 1 ~ 3%, sulphite 0 ~ 0.2%, medicinal glycerin 3 ~ 5%, titanium dioxide 2 ~ 3%;
Described cellulose gum and red algae card handkerchief glue compound gel are carboxymethyl cellulose salt SCMC, hydroxypropyl emthylcellulose HPMC and red algae card handkerchief glue mix by weight the ratio for 8:80:12.
2. cellulose gum according to claim 1 and the composite plant hollow capsule of red algae card handkerchief glue, it is characterized in that, red algae card handkerchief glue is red algae KAPPA glue.
3. a preparation method for cellulose gum and the composite plant hollow capsule of red algae card handkerchief glue, is characterized in that, comprise the steps:
Steps A, is mixed into cellulose gum and carrageenan compound gel by carboxymethyl cellulose salt SCMC, hydroxypropyl emthylcellulose HPMC and red algae card handkerchief glue by weight the ratio for 8:80:12;
Step B, by weight percentage, take cellulose gum and the red algae card handkerchief glue compound gel of 88 ~ 90%, add distilled water, under rapid mixing conditions, the described cellulose gum of slow interpolation and red algae card handkerchief glue compound gel, mix and blend 10 minutes, then moves in interlayer steam cooker, be heated to 88 DEG C, and fully stir, 30 minutes response time, make it dissolve uniformly glue;
Step C, adds the potassium chloride of 1 ~ 3%, the sulphite of 0 ~ 0.2% by weight percentage successively, the medicinal glycerin of 3 ~ 5%, the titanium dioxide of 2 ~ 3%, and stir, glue temperature is down to 50 DEG C, continues insulated and stirred l ~ 2 hour, formed and dip in gum forming solution;
Step D, prepares capsule blank with capsule die mode dunking method, more prepared capsule blank is carried out dried, and baking temperature remains on 30 ~ 35 DEG C, 1 ~ 2 hour drying time, namely obtains the plant hollow capsule be shaped after finally carrying out the demoulding.
4. cellulose gum according to claim 3 and the composite plant hollow capsule preparation method of red algae card handkerchief glue, it is characterized in that, red algae card handkerchief glue is red algae KAPPA glue.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510113319.XA CN104758271A (en) | 2015-03-16 | 2015-03-16 | Plant vacant capsule compounded from cellulose gum and red alga KAPPA gum and preparation method thereof |
| PCT/CN2015/075883 WO2016145696A1 (en) | 2015-03-16 | 2015-04-03 | Plant hollow capsule compounded from cellulose gum and red algae kappa gum, and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510113319.XA CN104758271A (en) | 2015-03-16 | 2015-03-16 | Plant vacant capsule compounded from cellulose gum and red alga KAPPA gum and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104758271A true CN104758271A (en) | 2015-07-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510113319.XA Pending CN104758271A (en) | 2015-03-16 | 2015-03-16 | Plant vacant capsule compounded from cellulose gum and red alga KAPPA gum and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104758271A (en) |
| WO (1) | WO2016145696A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853390A (en) * | 2016-05-20 | 2016-08-17 | 夏放军 | Natural harmless hollow capsules and preparation method thereof |
| CN113507832A (en) * | 2018-11-06 | 2021-10-15 | 德罗纳斯德公司 | Capsule planting system and method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000067723A2 (en) * | 1999-05-10 | 2000-11-16 | Roland Bodmeier | Form of administration for applying in body orifices |
| CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
| CN102895215A (en) * | 2012-10-18 | 2013-01-30 | 广西南宁汇润生物科技有限公司 | Cellulose and red alga polysaccharide plant empty capsule and raw material composition and preparation method thereof |
| CN104274424A (en) * | 2014-09-05 | 2015-01-14 | 韩字光 | Plant empty capsule and manufacturing method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1276779C (en) * | 2005-07-01 | 2006-09-27 | 唐连德 | Hollow capsule material composition of plant polysaccharide and production of hollow capsule |
| CN101167705B (en) * | 2007-11-13 | 2010-08-18 | 北京长征天民高科技有限公司 | Composition for preparing plant hollow hard capsule and preparation method of capsule |
-
2015
- 2015-03-16 CN CN201510113319.XA patent/CN104758271A/en active Pending
- 2015-04-03 WO PCT/CN2015/075883 patent/WO2016145696A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000067723A2 (en) * | 1999-05-10 | 2000-11-16 | Roland Bodmeier | Form of administration for applying in body orifices |
| CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
| CN102895215A (en) * | 2012-10-18 | 2013-01-30 | 广西南宁汇润生物科技有限公司 | Cellulose and red alga polysaccharide plant empty capsule and raw material composition and preparation method thereof |
| CN104274424A (en) * | 2014-09-05 | 2015-01-14 | 韩字光 | Plant empty capsule and manufacturing method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853390A (en) * | 2016-05-20 | 2016-08-17 | 夏放军 | Natural harmless hollow capsules and preparation method thereof |
| CN113507832A (en) * | 2018-11-06 | 2021-10-15 | 德罗纳斯德公司 | Capsule planting system and method |
| US11985914B2 (en) | 2018-11-06 | 2024-05-21 | Droneseed Co. | Predation-resistant capsular planting systems and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016145696A1 (en) | 2016-09-22 |
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Application publication date: 20150708 |