CN104738627A - Vitamin linseed oil compounded soft capsule and preparation method thereof - Google Patents
Vitamin linseed oil compounded soft capsule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a vitamin linseed oil compounded soft capsule and a preparation method of the vitamin linseed oil compounded soft capsule, aiming at solving the problem that a water-soluble component added to linseed oil cannot be dissolved in an oil-soluble component well. The soft capsule is composed of a content and a gum solution, wherein the content is prepared from 80-95% of linseed oil, 1.5-15% of water soluble vitamin micro-capsule and 1.0-10% of fat-soluble vitamin; the gum solution is prepared from the following substances in volume percentage: 30-60% of starch octenyl succinate anhydride, 10-20% of glycerin and 20-60% of purified water. The preparation method comprises the following steps: (1) preparing water soluble vitamin; (2) extracting linseed oil from linseeds by adopting a cold extraction method; (3) embedding the water soluble vitamin by use of the microcapsule technology; and (4)preparing the soft micro-capsules by use of the content and the gum by using a soft capsule making machine through pressing. The process is simple and can be operated easily, the product is good in stability and high in absorption and utilization rate, and bad mouthfeel of vitamins is covered.
Description
Technical field
The invention belongs to health food, particularly relate to a kind of vitamin linseed oil compound capsules and preparation method thereof.
Background technology
Linseed (flaxseed or linseed), also known as flaxseed, is the seed of annual or herbaceos perennial flax of flax family (Linaceae), linum, has become one of large oil crops in the world ten.In China, its annual production is about 400,000 tons, occupies the 4th, the world, has become the vegetable oil material that China is important.Linseed oil, also known as linseed oil or siritch, is the drying oil produced from linseed.Linseed oil outward appearance is yellow, transparent, have pleasant linseed oil smell, and containing multiple aliphatic acid such as palmitic acid, stearic acid, oleic acid, linoleic acid, leukotrienes, wherein alpha-linolenic acid is up to 40% ~ 60%.
It is the key ensureing human health that linoleic acid plus linolenic acid equilibrium is between the two taken in.For a long time, the animal and plant fat of China's consumption of resident meets people to energy and delicious demand, but its aliphatic acid forms and is not suitable for the ratio of body metabolism demand, especially generally lacks n-3 polyunsaturated fatty acid.Since the nineties in 20th century, the result of domestic and international nutrition of lipids scholar to the physiological metabolism research in human body of all kinds of aliphatic acid shows, FAO (Food and Agriculture Organization of the United Nation) and Chinese Soclety of Nutrition be suggestion all successively, and human body takes in following (1) saturated fatty acid (SFA) of suitable proportion of various aliphatic acid: monounsaturated fatty acids (MUFA): polyunsaturated fatty acid (PUFA)=1:1:1.(2) in polyunsaturated fatty acid, the ratio of n-6 and n-3 is 4:1 ~ 6:1.But the ratio of n-3 and n-6 aliphatic acid is about 1:14 in traditional food.Therefore, for general people, alpha-linolenic acid generally lacks.Alpha-linolenic acid is the how unsaturated essential fatty acid of one, plays a decisive role to health.It is the basic substance forming cell membrane and biology enzyme, simultaneously in the generation maintaining the other diseases such as lipoprotein balance, reducing blood lipid, adjustment cholesterol metabolic, hypotensive, antithrombotic, reduction and prevention canceration and development, there is important function, its metabolite EPA and DHA is the precursor of triolefin prostaglandin in body and the main component of the nerve cell such as brain and retina membrane phospholipid, it can not only improve nervous function, there is facilitation to learning and memory and behavioral activity, go back immunity-regulating systemic-function etc.
Although linseed oil has had some to apply in China's food industry, but its level of application is not directly proportional with its nutritive value, for a long time, it is main that the linseed of China mainly at source squeezes edible oil self-digestion, and the potential value of linseed oil is not also exploited.Compared with deep sea fish oil, linseed is fully natural green plant, does not have the danger of marine pollution, not containing cholesterol, does not have fishlike smell, and low price, and raw material is sufficient.In recent years, along with people deepen the understanding of diet and healthy relation, linseed oil more and more receives publicity, and the temperature studied in the world surpasses fish oil.
Linseed oil also has a weak point, and the nutrient composition content being exactly other is relatively less.At present, existing health product is made up of jointly linseed oil and nutrient mostly, to reach the object of various nutritional labeling equilibrium.Wherein nutrient is mainly fat soluble vitamin and water soluble vitamin, but water soluble ingredient can not well be dissolved in oil-soluble ingredients.
Summary of the invention
The object of this invention is to provide a kind of vitamin linseed oil compound capsules, well can not be dissolved in problem in oil-soluble ingredients to solve the water soluble ingredient added in linseed oil.
Another object of the present invention is to provide a kind of preparation method of vitamin linseed oil compound capsules.
For solving the problem, the technical solution adopted in the present invention is: a kind of vitamin linseed oil compound capsules, it is by content and rubber solution composition, and wherein content is made up of the material of following masses percentage composition: linseed oil 80 ~ 95%, water soluble vitamin micro-capsule 1.5 ~ 15% and liposoluble vitamin 1.0 ~ 10%; Rubber solution is made up of the material of following volumn concentration: starch octenyl succinate anhydride 30 ~ 60%, glycerine 10 ~ 20% and pure water 20 ~ 60%.
Preferably, described water soluble vitamin micro-capsule is combined by core and wall material, and core is ascorbic acid (V
c), thiamine hydrochloride (V
b1), riboflavin (V
b2), puridoxine hydrochloride (V
b6), folic acid (V
b12), cigarette propylhomoserin (V
b3) in three kinds to five kinds, wall material is obtained by capsule material, and capsule material is starch octenyl succinate anhydride.
Preferably, described liposoluble vitamin is one or both in VitAVitE or vitamin D.
The preparation method of said vitamin linseed oil compound capsules, formed by content and rubber solution encapsulating machine pressure, content is mixed by linseed oil, water soluble vitamin micro-capsule and liposoluble vitamin, and wherein the preparation technology of water soluble vitamin micro-capsule is:
(1) core is prepared: by mixing soluble in water for water soluble vitamin, make core material solution;
(2) prepare wall material: be configured to soluble in water for capsule material starch octenyl succinate anhydride the solution that mass concentration is 1%-3%, make its fully swelling, dispersion, in 40-60 DEG C of water-bath, heating makes it dissolve, and makes wall material solution;
(3) mix: core material solution joined in wall material solution, be stirred to abundant mixing, the mass ratio of wall material and core is 5 ~ 15:1;
(4) microcapsules are prepared: adopt spray drying process to prepare water soluble vitamin micro-capsule, the process conditions of spray drying process are: EAT 160 ~ 180 DEG C, feed rate 3 ~ 4mL/min.
Preferably, above-mentioned linseed oil is extracted by following technique and obtains:
(1) clear up, pulverize, sieve: linseed is cleaned up after drying and pulverize, cross 40 ~ 60 mesh sieves;
(2) ultrasonic wave process: the linseed after pulverizing is put into bottle, and add solvent, solid-liquid ratio is 1:4 ~ 8 mass volume ratio; Be treated to supplementary means with ultrasonic wave, in supersonic generator, carry out grease extraction, ultrasonic power is: 180 ~ 540W, and sonication treatment time is: 10 ~ 40min, and ultrasonic treatment temperature is: 20 ~ 60 DEG C;
(3) be separated: the mixture of the solvent in step (2) with oil is separated with residue;
(4) rotary evaporation crude oil: the filtrate in step (3) is placed in except desolventizing on Rotary Evaporators, the linseed crude oil obtained;
(5) linseed oil: by the linseed crude oil in step (4) at 40 ~ 60 DEG C, vacuum dry 0.5 ~ 1.5h under being 6 ~ 8kPa, obtain linseed oil.
Preferably, the solvent in above-mentioned steps (2) is the one in benzinum, ethanol or n-hexane.
The beneficial effect of advantage of the present invention and generation is as follows:
1. the present invention utilizes microcapsules technology, water soluble vitamin is rolled into tiny capsules, solve water soluble ingredient and can not be dispersed in this problem in oil-soluble ingredients well, the release of the stability of product, absorption rate, slowly-releasing or controlled release of active ingredients can also be improved simultaneously, and mask the bad mouthfeel of vitamin, be convenient to the storage of product, use, stabilate is active, contributes to playing curative effect.
2.. the low and starch octenyl succinate anhydride replacing gelatin that security is high of the present invention's valency is as wall material, forms the rubber of vitamin linseed oil compound capsules, thus reduce cost and security to a certain extent with glycerine and pure water.
3. present invention process is simple, is easy to operation;
4. the vitamin linseed oil compound capsules prepared of the present invention, technique is simple, is easy to operation, and good stability, the absorption rate of product be high, the bad mouthfeel that masks vitamin.Products obtained therefrom of the present invention also has certain health care, there is the effect maintaining the other diseases generations such as lipoprotein balance, reducing blood lipid, adjustment cholesterol metabolic, hypotensive, antithrombotic, reduction and prevention canceration, also there is the function such as brain tonic and intelligence development, immunity moderation system, guarantee human body is balanced in nutrition, be conducive to maintaining health, and can sub-health state be improved to a certain extent.
Detailed description of the invention
The following examples can further illustrate the present invention, but do not limit the present invention in any way.
In embodiment, linseed, water soluble vitamin, liposoluble vitamin are commercially available, and starch octenyl succinate anhydride is product (CN101624423A, 2010.01.13 announce) prepared by the patented method of the applicant.
embodiment 1
Content and the rubber solution encapsulating machine of vitamin linseed oil compound capsules are pressed into micro-capsule soft capsule preparation,
1. content is made up of the material of following masses percentage composition: linseed oil 80%, water soluble vitamin micro-capsule 15% and liposoluble vitamin 5%;
Water soluble vitamin micro-capsule is combined by core and wall material,
Core is made up of the material of following mass percentage: riboflavin (V
b2) 8.25%, puridoxine hydrochloride (V
b6) 6.74% and folic acid (V
b12) 0.01%; Liposoluble vitamin is vitamin E.
2. rubber is made up of the material of following masses percentage composition: starch octenyl succinate anhydride 30%, glycerine 20%, pure water 50%.
3. above-mentioned linseed oil is extracted by following technique:
(1) clear up, pulverize, sieve: linseed is cleaned up after drying and pulverize, cross 40 mesh sieves;
(2) ultrasonic wave process: the linseed accurately taken after pulverizing puts into conical flask take ethanol as solvent, and solid-liquid ratio is 1:4 mass volume ratio.Be treated to supplementary means with ultrasonic wave, in supersonic generator, carry out grease extraction.Ultrasonic power is: 180W, and sonication treatment time is: 10min, and ultrasonic treatment temperature is: 20 DEG C;
(3) be separated: the mixture of the solvent in step (2) with oil is separated with residue;
(4) rotary evaporation crude oil: the filtrate in step (3) is placed in except desolventizing on Rotary Evaporators, the linseed crude oil obtained;
(5) linseed oil: by the crude oil in step (4) 40 DEG C, vacuum be 6kPa under dry 0.5h, obtain linseed oil.
4. the preparation technology of water soluble vitamin micro-capsule is:
(1) core is prepared: by water soluble vitamin riboflavin (V
b2), puridoxine hydrochloride (V
b6), folic acid (V
b12) mixing soluble in water, make core material solution;
(2) prepare wall material: be configured to soluble in water for capsule material starch octenyl succinate anhydride the solution that mass concentration is 1%, make its fully swelling, dispersion, in 40 DEG C of water-baths, heating makes it dissolve, and makes wall material solution;
(3) mix: core material solution joined in wall material solution, be stirred to abundant mixing, the mass ratio of wall material and core is 5:1;
(4) prepare microcapsules: adopt existing spray drying process to prepare water soluble vitamin micro-capsule, determine that the process conditions of spray drying process are: EAT 160 DEG C, feed rate 3mL/min.
embodiment 2
Content and the rubber solution encapsulating machine of vitamin linseed oil compound capsules are pressed into micro-capsule soft capsule preparation,
1. content is made up of the material of following masses percentage composition: linseed oil 90%, water soluble vitamin micro-capsule 12% and liposoluble vitamin 8%, and water soluble vitamin micro-capsule is combined by core and wall material,
Core is made up of the material of following mass percentage: ascorbic acid (V
c) 3.55%, thiamine hydrochloride (V
b1) 2.92%, riboflavin (V
b2) 3.21%, puridoxine hydrochloride (V
b6) 2.31% and folic acid (V
b12) 0.01%.
Liposoluble vitamin be following mass percentage material composition: vitamin E account for 6% and vitamin A account for 2%.
2. rubber is made up of the material of following masses percentage composition: starch octenyl succinate anhydride 45%, glycerine 15%, pure water 40%.
3. above-mentioned linseed oil is extracted by following technique:
(1) clear up, pulverize, sieve: linseed is cleaned up after drying and pulverize, cross 50 mesh sieves;
(2) ultrasonic wave process: the linseed after pulverizing is put into conical flask, and take benzinum as solvent, solid-liquid ratio is 1:6 mass volume ratio.Be treated to supplementary means with ultrasonic wave, in supersonic generator, carry out grease extraction.Ultrasonic power is: 540W, and sonication treatment time is: 40min, and ultrasonic treatment temperature is: 40 DEG C;
(3) be separated: the mixture of the solvent in step (2) with oil is separated with residue;
(4) rotary evaporation crude oil: the filtrate in step (3) is placed in except desolventizing on Rotary Evaporators, the linseed crude oil obtained;
(5) linseed oil: by the crude oil in step (4) 60 DEG C, vacuum be 8kPa under dry 1h, obtain linseed oil.
4. the preparation technology of water soluble vitamin micro-capsule is:
(1) core is prepared: by water soluble vitamins ascorbic acid (V
c), thiamine hydrochloride (V
b1), riboflavin (V
b2), puridoxine hydrochloride (V
b6), folic acid (V
b12) mixing soluble in water, make core material solution;
(2) prepare wall material: be configured to soluble in water for capsule material starch octenyl succinate anhydride the solution that mass concentration is 2%, make its fully swelling, dispersion, in 50 DEG C of water-baths, heating makes it dissolve, and makes wall material solution;
(3) mix: core material solution is joined in wall material solution, be stirred to abundant mixing.The mass ratio of wall material and core is 10:1;
(4) microcapsules are prepared: adopt spray drying process to prepare water soluble vitamin micro-capsule.The process conditions of spray drying process are: EAT 170 DEG C, feed rate 3.5mL/min.
embodiment 3
Content and the rubber solution encapsulating machine of vitamin linseed oil compound capsules are pressed into micro-capsule soft capsule preparation,
1. content is made up of the material of following masses percentage composition: linseed oil 95%, water soluble vitamin micro-capsule 3% and liposoluble vitamin 2%.Water soluble vitamin micro-capsule is combined by core and wall material,
Core is made up of the material of following mass percentage: thiamine hydrochloride (V
b1) 1.75%, riboflavin (V
b2) 1.22%, folic acid (V
b12) 0.01%, cigarette propylhomoserin (V
b3) 0.02%; Liposoluble vitamin is vitamin E.
2. rubber is made up of the material of following masses percentage composition: starch octenyl succinate anhydride 60%, glycerine 10%, pure water 30%.
3. above-mentioned linseed oil is extracted by following technique:
(1) clear up, pulverize, sieve: linseed is cleaned up after drying and pulverize, cross 60 mesh sieves;
(2) ultrasonic wave process: the linseed after pulverizing is put into conical flask, and take n-hexane as solvent, solid-liquid ratio is 1:8 mass volume ratio.Be treated to supplementary means with ultrasonic wave, in supersonic generator, carry out grease extraction.Ultrasonic power is: 360W, and sonication treatment time is: 25min, and ultrasonic treatment temperature is: 60 DEG C;
(3) be separated: the mixture of the solvent in step (2) with oil is separated with residue;
(4) rotary evaporation crude oil: the filtrate in step (3) is placed in except desolventizing on Rotary Evaporators, the linseed crude oil obtained;
(5) linseed oil: by the crude oil in step (4) 50 DEG C, vacuum be 7kPa under dry 1.5h, obtain linseed oil.
4. the preparation technology of water soluble vitamin micro-capsule is:
(1) core is prepared: by water soluble vitamin, thiamine hydrochloride (V
b1), riboflavin (V
b2), folic acid (V
b12), cigarette propylhomoserin (V
b3) in one or more mixings soluble in water, make core material solution;
(2) prepare wall material: be configured to soluble in water for capsule material starch octenyl succinate anhydride the solution that mass concentration is 3%, make its fully swelling, dispersion, in DEG C water-bath, heating makes it dissolve, and makes wall material solution.
(3) mix: core material solution is joined in wall material solution, be stirred to abundant mixing.The mass ratio of wall material and core is 15:1.
(4) microcapsules are prepared: adopt spray drying process to prepare water soluble vitamin micro-capsule.The process conditions of spray drying process are: EAT 180 DEG C, feed rate 4mL/min.
Claims (6)
1. a vitamin linseed oil compound capsules, it is characterized in that: it is by content and rubber solution composition, and wherein content is made up of the material of following masses percentage composition: linseed oil 80 ~ 95%, water soluble vitamin micro-capsule 1.5 ~ 15% and liposoluble vitamin 1.0 ~ 10%; Rubber solution is made up of the material of following volumn concentration: starch octenyl succinate anhydride 30 ~ 60%, glycerine 10 ~ 20% and pure water 20 ~ 60%.
2. according to the vitamin linseed oil compound capsules described in claim 1, it is characterized in that: described water soluble vitamin micro-capsule is combined by core and wall material, core is three kinds to five kinds in ascorbic acid, thiamine hydrochloride, riboflavin, puridoxine hydrochloride, folic acid, cigarette propylhomoserin, wall material is obtained by capsule material, and capsule material is starch octenyl succinate anhydride.
3. according to the vitamin linseed oil compound capsules described in claim 1 or 2, it is characterized in that: described liposoluble vitamin is one or both in VitAVitE or vitamin D.
4. the preparation method of vitamin linseed oil compound capsules described in claim 1, it is characterized in that: it is formed by content and rubber solution encapsulating machine pressure, content is mixed by linseed oil, water soluble vitamin micro-capsule and liposoluble vitamin, and wherein the preparation technology of water soluble vitamin micro-capsule is:
(1) core is prepared: by mixing soluble in water for water soluble vitamin, make core material solution;
(2) prepare wall material: be configured to soluble in water for capsule material starch octenyl succinate anhydride the solution that mass concentration is 1%-3%, make its fully swelling, dispersion, in 40-60 DEG C of water-bath, heating makes it dissolve, and makes wall material solution;
(3) mix: core material solution joined in wall material solution, be stirred to abundant mixing, the mass ratio of wall material and core is 5 ~ 15:1;
(4) microcapsules are prepared: adopt spray drying process to prepare water soluble vitamin micro-capsule, the process conditions of spray drying process are: EAT 160 ~ 180 DEG C, feed rate 3 ~ 4mL/min.
5. the preparation method of vitamin linseed oil compound capsules described in claim 4, is characterized in that: described linseed oil is extracted by following technique and obtains:
(1) clear up, pulverize, sieve: linseed is cleaned up after drying and pulverize, cross 40 ~ 60 mesh sieves;
(2) ultrasonic wave process: the linseed after pulverizing is put into bottle, and add solvent, solid-liquid ratio is 1:4 ~ 8 mass volume ratio; Be treated to supplementary means with ultrasonic wave, in supersonic generator, carry out grease extraction, ultrasonic power is: 180 ~ 540W, and sonication treatment time is: 10 ~ 40min, and ultrasonic treatment temperature is: 20 ~ 60 DEG C;
(3) be separated: the mixture of the solvent in step (2) with oil is separated with residue;
(4) rotary evaporation crude oil: the filtrate in step (3) is placed in except desolventizing on Rotary Evaporators, the linseed crude oil obtained;
(5) linseed oil: by the linseed crude oil in step (4) at 40 ~ 60 DEG C, vacuum dry 0.5 ~ 1.5h under being 6 ~ 8kPa, obtain linseed oil.
6. the preparation method of vitamin linseed oil compound capsules described in claim 5, is characterized in that: the solvent in described step (2) is the one in benzinum, ethanol or n-hexane.
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| CN106723064A (en) * | 2016-12-13 | 2017-05-31 | 广州富诺健康科技股份有限公司 | A kind of vitamin D3Soft capsule and preparation method thereof |
| CN108851058A (en) * | 2018-07-13 | 2018-11-23 | 德瑞美医药生物技术盐城有限公司 | A kind of multivitamin minerals soft capsule and preparation method thereof rich in alpha-linolenic acid |
| CN108968070A (en) * | 2018-08-13 | 2018-12-11 | 河南城建学院 | A kind of linseed omega-3 unsaturated fatty acid health care product and its microcapsule preparation method |
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| CN108851058A (en) * | 2018-07-13 | 2018-11-23 | 德瑞美医药生物技术盐城有限公司 | A kind of multivitamin minerals soft capsule and preparation method thereof rich in alpha-linolenic acid |
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Application publication date: 20150701 |