CN104721840A - Tracer for raising detection rate of sentinel lymph node of breast cancer and preparation method thereof - Google Patents
Tracer for raising detection rate of sentinel lymph node of breast cancer and preparation method thereof Download PDFInfo
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- CN104721840A CN104721840A CN201310716960.3A CN201310716960A CN104721840A CN 104721840 A CN104721840 A CN 104721840A CN 201310716960 A CN201310716960 A CN 201310716960A CN 104721840 A CN104721840 A CN 104721840A
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- tracer
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- breast cancer
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Abstract
The invention relates to a tracer for raising detection rate of sentinel lymph node of breast cancer and a preparation method of the preparation. The tracer is prepared as follows: 1ml 1% of methylthioninium chloride injection and 2.5ml 2% lidocaine hydrochloride injection are extracted by the use of a syringe; and normal saline is added to reach 5 ml so as to prepare a compound injection containing 0.2% methylene blue and 1% of lidocaine. A syringe is used to inject the prepared tracer in a point-like form under the skin around mammary areola of a patient's breast, and the total dosage of the tracer is 2ml to 4ml. Then, along the dilated blue-stained lymphatic vessels, all blue-stained lymph nodes are taken out to be inspected. The method has advantages of low cost, easy acquisition, no radiation, no requirement of special instrument detection and the like. By the method, detection rate of sentinel lymph node is raised, and cutaneous necrosis caused by methylene blue is avoided. The method is worth of popularization and application in various hospitals.
Description
Technical field
The present invention relates to and a kind ofly improve the tracer of sentinel lymph nodes of breast cancer recall rate and the collocation method of said preparation, this tracer can significantly improve the probability that sentinel lymph nodes of breast cancer detects and the number detecting lymph node, clinical treatment for next step provides strong guidance, and the use of radionuclide can be substituted, stop the chance that patient and medical worker contact nucleic.
Background technology
When patient with breast cancer selects operative treatment mode, first should determine whether there is the sentinel node transfer of axillary fossa, invade if sentinel node is not subject to cancer, then need not carry out ALND; Invade if sentinel node has been subject to cancerous cell, generally need to clean axillary gland.Therefore, find sentinel node and it detected smoothly to instructing next step therapeutic modality most important.
Existing sentinel node tracer generally selects radionuclide, fluorescent dye, dyestuff etc.Radionuclide method needs to inject radionuclide in patient body, and patient and associated medical person all can be subject to nucleic radiation in various degree, and this reagent needs the preparation of special section office, specialized equipment detects, and access threshold is high, and basic unit is difficult to promote; Fluorescent dye determination also needs specialized equipment to detect, and high, the disposable input of access threshold is many, still difficult universal; Current domestic situation of all-level hospitals many employings dye method as tracer, methylene blue wherein because cheap, obtain easily, need not the advantage such as specific apparatus detection, adopted by medical worker at most.But methylene blue exists lymph nodes number shortcoming on the low side as tracer, when methylene blue concentration is higher, also injection site cutaneous necrosis can be caused.
Summary of the invention
In order to overcome many deficiencies of above-mentioned tracer, the invention provides and a kind ofly improve the tracer of sentinel lymph nodes of breast cancer recall rate and the collocation method of said preparation.The method inherit methylene blue method cheap, obtain easy, radiationless, need not the advantage such as specific apparatus detection, improve sentinel node recall rate, avoid the cutaneous necrosis that methylene blue causes simultaneously.
The present invention solves the current methylene blue that uses: the method changing injection methylene blue stock solution or normal saline dilution methylene blue at present, lidocaine hydrochloride injection and methylthioninium chloride injection are carried out compatibility, reduce the concentration of methylene blue, improve sentinel node recall rate.
The invention has the beneficial effects as follows, the methylene blue of compatibility and lignocaine make the lowering of concentration of methylene blue again, there will not be the cutaneous necrosis of injection site; The use of local anesthetic lignocaine makes pain during tracer injection obviously decline; Lignocaine impels lymphangiectasis, and the lymphatic vessel increasing thick blue dye is easy to find, improve the recall rate of sentinel node, the quantity that detects of sentinel node also obviously increases simultaneously.
Tracer configuration of the present invention is as follows: syringe extracts 1ml1% methylthioninium chloride injection+2.5ml2% lidocaine hydrochloride injection, adds normal saline to 5ml, is configured to the compound injection containing 0.2% methylene blue and 1% lignocaine.
Detailed description of the invention
Syringe point-like is used to be injected in the mammary areola surrounding subcutaneous of ill breast, total consumption 2ml to 4ml the above-mentioned tracer configured.Soft massage injection site, after 5 minutes, cuts skin, and the lymphatic vessel following the blue dye of expansion moves ahead, through sentinel node place, takes out the lymph node of all indigo plant dyes, delivers to Pathology Deparment and check.
Although the present invention discloses as above with preferred embodiment, but and be not used to limit scope of the invention process, any medical worker, every do according to creation spirit of the present invention compatibility concentration change, diluent kind the embodiment such as adjustment and the tracer using it for other tumor sentinel nodes all should be contained among the present invention.
Claims (4)
1. improve tracer and the preparation method of sentinel lymph nodes of breast cancer recall rate, it is characterized by, this tracer comprises 1ml1% methylthioninium chloride injection+2.5ml2% lidocaine hydrochloride injection, adds normal saline to 5ml.
2. according to tracer according to claim 1, the concentration of methylene blue is 0.2%, and the concentration of lignocaine is 1%.
3., according to tracer according to claim 1, when using as sentinel node tracer, the compatibility adjustment of methylthioninium chloride injection and any ratio of lidocaine injection all belongs to the scope of patent of the present invention.
4., according to tracer according to claim 1, when the tracer as other tumor sentinel nodes uses, belong to the scope of the claims of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310716960.3A CN104721840A (en) | 2013-12-23 | 2013-12-23 | Tracer for raising detection rate of sentinel lymph node of breast cancer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310716960.3A CN104721840A (en) | 2013-12-23 | 2013-12-23 | Tracer for raising detection rate of sentinel lymph node of breast cancer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104721840A true CN104721840A (en) | 2015-06-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201310716960.3A Pending CN104721840A (en) | 2013-12-23 | 2013-12-23 | Tracer for raising detection rate of sentinel lymph node of breast cancer and preparation method thereof |
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| CN (1) | CN104721840A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260137A (en) * | 2017-07-31 | 2017-10-20 | 济南显微智能科技有限公司 | It is a kind of to detect ICG and double Tracing detection device and methods of methylenum careuleum simultaneously |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU906532A1 (en) * | 1980-06-13 | 1982-02-23 | Ростовский научно-исследовательский онкологический институт | Method of preparing patient to lymphoinfusion |
| EP2620144A1 (en) * | 2012-01-27 | 2013-07-31 | Medical Technology Transfer Holding B.V. | Staining Composition |
-
2013
- 2013-12-23 CN CN201310716960.3A patent/CN104721840A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU906532A1 (en) * | 1980-06-13 | 1982-02-23 | Ростовский научно-исследовательский онкологический институт | Method of preparing patient to lymphoinfusion |
| EP2620144A1 (en) * | 2012-01-27 | 2013-07-31 | Medical Technology Transfer Holding B.V. | Staining Composition |
Non-Patent Citations (1)
| Title |
|---|
| 刘汉前等: ""蓝染法定位CN0舌癌前哨***的价值"", 《临床口腔医学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260137A (en) * | 2017-07-31 | 2017-10-20 | 济南显微智能科技有限公司 | It is a kind of to detect ICG and double Tracing detection device and methods of methylenum careuleum simultaneously |
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| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150624 |
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| RJ01 | Rejection of invention patent application after publication |