CN104721248A - Composition with antidepressant effect and application thereof - Google Patents
Composition with antidepressant effect and application thereof Download PDFInfo
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- CN104721248A CN104721248A CN201510184623.3A CN201510184623A CN104721248A CN 104721248 A CN104721248 A CN 104721248A CN 201510184623 A CN201510184623 A CN 201510184623A CN 104721248 A CN104721248 A CN 104721248A
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a composition with an antidepressant effect and application thereof. Specifically, the composition is made of following active substances comprising acanthopanax trifoliatus and maca, and the composition further comprises agilawood. According to another implementation scheme, the composite is made of following active substances comprising the acanthopanax trifoliatus and the agilawood. The composition is used for preventing depression, relieving pressure and low mood, soothing mood and the like, an excellent biological efficacy is achieved.
Description
Technical field
The invention belongs to health-oriented products field, relate to a kind of compositions with antidepressant effect, and the purposes of said composition.Compositions of the present invention can use as health promoting product, health food, health beverage or medical product.
Background technology
White le, Latin literary fame: Acanthopanax trifoliatus (L.) Merr. hangs down loosely shrub, often seeks connections with and does on other shrubs or arbor.People often use its tender stem and leaf, and therefore Bai le Cheng also Weis LECAI (namely refering in particular to tender stem and the leaf of Bai le) by people usually.Bai le is palmately compound leaf, and usually have 3, lobule, petiole spinosity, lobule ellipticity is avette.Autumn and winter extract umbel out, petal yellow green, and fruit is spherical, and winter is ripe, ripe rear black.LECAI is clustered in the wild, and its stem and leaf is dark green, and leaf is little and many, and stem is barbed, and edible top end young stem and leaf, is mainly used to make soup.Produce various places on the south the Changjiang river; Vietnam, Philippine, Japan.Shenzhen sees Buji Mt Jigong and Nan Aodong gushes, cloud etc. half a day ground.Root and leaf people medicine, have the effect of heat-clearing and toxic substances removing, expelling wind and removing dampness.In addition, the famous producing region of Guangdong Enping City Shi Bai le.
Bai le is the Araliaceae equal with Radix Ginseng, and be that a kind of nutrition and health care is worth very high wild vegetable, it is the top grade of QI invigorating effect that Shennong's Herbal records it." Shanxi. Mingyi Bielu " record the effect that it has invigorating middle warmer, QI invigorating, hard muscles and bones, strong will." bright. Compendium of Materia Medica " record its for a long time clothes make light of one's life by commiting suicide always resistance to." Wanshan Mountain medical herbs " records its venting QI-blood stasis, dispels the wind by wet, repercussive hemostasis and pain-relieving, heat-clearing and toxic substances removing." Guangdong medicinal plants short course " is recorded its root, stem and leaf and all can be used as medicine, root, expelling wind and removing dampness, repercussive pain relieving; Leaf. dispelling wind, detumescence, antipruritic, there is effect of relaxing muscles and tendons to promote blood circulation, subduing swelling and detoxicating.
Bai le has multiple dietetic therapy effect, can improve body immunity, improves blood vessel elasticity, and clean blood vessel, can promote cholesterol decomposition, can prevent influenza, upper respiratory tract infection; Containing glutamic acid in Bai le, there is brain-strengthening and strengthen the respiratory function of brain cell, being conducive to brain development.The chlorophyllous content of Bai le is very high, can strengthen heart merit difficult, affect vascular system, have dredging vascellum, blood fat reducing, blood pressure lowering, balance blood sugar, strengthens liver metabolism function.Having bacteriostasis simultaneously, can play assosting effect to anti-inflammation drugs, is therefore the desirable health food of diabetics auxiliary treatment.Bai le is a kind of bitterness food, and integration of edible and medicinal herbs, has effects for removing toxic heat.Guangdong Enping City white le of collection among the people has long history as health-care vegetable and medical material, its distinctive dietetic therapy effect, deeply likes by Enping City people, is the wild vegetable and nutritional health food liking in people from Enping City daily life eating.
Bai le is bitter, puckery, is slightly cold.There is removing pathogenic heat from blood and toxic substance from the body, by wind, effect of evacuation of pus.Be used for the treatment of rheumatic arthritis, lumbago and skelalgia, enteritis, dysentery clinically, frustrate sprain, osteomyelitis, bone tuberculosis; Heat clearing away; Promoting blood circulation and detumescence.Cold, fever; Cough chest pain; Rheumatic arthralgia; Fracture; Knife injury; Carbuncle skin ulcer furuncle furuncle; Aphtha; Eczema; Scabies; Insect-bite.
Bai le has higher nutritive value.Also contain abundant aminoacid and the mineral element of needed by human in Bai le tender leaf, branch top, total amino acid content reaches 20.8%, has brain-strengthening and strengthens the respiratory function of brain cell.Frequent Shi Bai le, can take in the needs of enough heats for human normal physiological activity.Bai le fragrance is unique, among the people popular using it as health-care vegetable, its distinctive dietetic therapy effect.Be one of wild herbs of mainly using of Xishuangbanna various nationalities, especially standingly in red-letter day eat wild herbs raw.
Lepidinm meyenii Walp (Maca), have another name called Maca, Peruvian ginseng, maka, maca-maca, maino, ayak chichira, ayak willku etc., use the rhizome of its likeness in form Radix Raphani sample hypertrophy, originate in the mountain area, Andean, South America of height above sea level 3500 ~ 4500 meters, mainly be distributed in the Puno ecotope in the middle part of Peru and Peru the southeastern city of Puno, for Cruciferae (Cruciferae) Lepidium (Lepidium) plant, Classification system Lepidiummeyenii.Also distribution is had on Chinese yunnan, Tibet, China, Bolivia and other places.
Lepidinm meyenii Walp can be divided into black Lepidinm meyenii Walp, purple Lepidinm meyenii Walp and yellow Lepidinm meyenii Walp (comprising white Lepidinm meyenii Walp) according to product phase and epidermis color and luster.The wherein content of the core index such as Lepidinm meyenii Walp alkene, macamide, vitamin and aminoacid, black Lepidinm meyenii Walp is significantly higher than purple Lepidinm meyenii Walp, and purple Lepidinm meyenii Walp is significantly higher than yellow Lepidinm meyenii Walp.Accordingly, the growth conditions of black Lepidinm meyenii Walp is the harshest, and output is also minimum, and purple Lepidinm meyenii Walp takes second place.Black Lepidinm meyenii Walp is most precious, and output generally accounts for 3%-5%; Purple Lepidinm meyenii Walp accounts for 10%-15%.
Lepidinm meyenii Walp is the plateau plant of Cruciferae, originates in the plateau plant in more than 4000 meters, South America Peru Andes.Significant effect is had to balanced human's hormone secretion containing exclusive macamide and Lepidinm meyenii Walp alkene.Lepidinm meyenii Walp has resisting fatigue, improves sperm quality, regains one's strength of body, improving water flood, anti-climacteric, active fertility, the effects such as hypermnesis.And Lepidinm meyenii Walp is that men and women is suitable for, also there is good regulating action to the climacteric syndrome of women.
The required special natural environment and climate of Lepidinm meyenii Walp (MACA).It requires height above sea level more than 3500 meters, weather is special and soil is fertile, day and night the temperature difference reaches more than 40 degree, and such place is all rarely found in the whole world, only possesses such condition in the excessive area in the Yunnan-Guizhou Plateau of Andes, original producton location normal pulse China and Qinghai-Tibet Platean.The land area that global range can plant Lepidinm meyenii Walp is limited, and plant a Lepidinm meyenii Walp (MACA) in these limited soils after, the land requirement recuperation several years is in order to recover fertility, otherwise soil can not continue to cultivate.Although the U.S. and Japan successful introduction, but mainly based on scientific research, because Lepidinm meyenii Walp (MACA) growth conditions is very special and require that soil is fertile, the local whole world is like this all very rare, the place possessing this condition can not realize mechanized cultivation, so the global output of Lepidinm meyenii Walp is extremely low, the demand in the whole world substantially cannot be met.The cultivated area that the U.S. and Japan introduce a fine variety is little, and the Lepidinm meyenii Walp (MACA) that the content of wherein active ingredient is more original than Peru is low, and on labour costs, also exceeds tens times than Peru, so expensive.But the U.S. and Japan are to Lepidinm meyenii Walp demand all very greatly, so remain maximum Lepidinm meyenii Walp importer so far.
Lepidinm meyenii Walp has obtained the relevant authentication of each Main Developed Countries in the world as health food, and base comprises the FDA of the U.S..Moreover, Lepidinm meyenii Walp (MACA) also food and agricultural organization of united state (FAO) is listed among catalogue, that one of edible safety food is recommended by food and agricultural organization of united state, in order to improve people's malnutrition, nutrition unbalanced (life good do not represent balanced in nutrition), improve human body immune function and to improve reproductivity (sexuality) and completely without any toxic and side effects.Be that a kind of colloidal state needs to grow in rich soil with other common agricultural unlike, Lepidinm meyenii Walp (MACA), in final-period management process, other fertilizer can not be applied.Under the specific condition of height above sea level more than 4000 meters, it is almost life forbidden zone, do not need to use chemical agent parasite killing, because Foliage Absorption is very capable, also cannot use chemical agent weeding, plantation overall process uses manually completely, and in this unfrequented place, also do not have other industrial pollution, therefore this is a kind of real natural nuisance-free pollution-free food.In addition, Lepidinm meyenii Walp (MACA) has been eaten several thousand by local resident in Peru, never the clinical manifestation of addicted or drug dependence, so edible Lepidinm meyenii Walp (MACA) or Lepidinm meyenii Walp product are safe.Chinese yunnan Shanxi Academy of Agricultural Sciences high mountain economic plants institute started in Yulong Mountain Yunnan height above sea level more than 3000 meters region successful introduction in 2003, planting technology is comparatively ripe, cultivated area progressively expands, be with at Lijiang, yunnan Yulong Xueshan one, Huize, yunnan, the ground such as Shangri-la starts to produce Lepidinm meyenii Walp, now realized scale plantation.Main producing region is distributed in the ground such as Yulong Mountain Yunnan, and its quality can compare favourably with Peru's Lepidinm meyenii Walp quality.
Fresh Lepidinm meyenii Walp (MACA) moisture content 10.4%, protein 10.2%, fat 2.2%, carbohydrate 59%, fiber 8.5%, ash 4.9%.Aminoacid containing abundant needed by human, as: arginine (9.94%), aspartic acid (9.17%), glutamic acid (15.6%) and lysine (54.5%) etc.In the fatty acid of Lepidinm meyenii Walp (MACA), the content of unsaturated fatty acid accounts for 52.7% (its Linoleic acid 18.5%, linolenic acid 8.87%), containing glucosinolate (glucosinolates) sterol and potassium, calcium, ferrum etc.Lepidinm meyenii Walp alkene (macaenes) and macamide (mecamides) are contained in Lepidinm meyenii Walp (MACA) lipid position, also comprise N-benzyl caprylamide, N-benzyl-16-hydroxyl-9-oxidation-10E, 12E, 14E-pungent certain herbaceous plants with big flowers triolefin amide, N-benzyl-16 hydroxyl-9,16-dioxy-10E, the homologue of 12E, 14E-pungent certain herbaceous plants with big flowers triolefin amide and other 17 Lepidinm meyenii Walp alkene and macamide.Lepidinm meyenii Walp alkene and macamide are considered to tool in Lepidinm meyenii Walp (MACA) extract and promote one of active substance of sexual function.
Lepidinm meyenii Walp is rich in vigor nutrient, aminoacid, vitamin and several mineral materials, also containing secondary metabolites and multiple bioactive ingredients such as alkaloid, glucosinolate, sterols, Lepidinm meyenii Walp at blood fat reducing, endocrine regulation, hypersexuality, the treatment of sexual dysfunction, resisting fatigue, antioxidation, improve in climacteric syndrome, antitumor, treatment anemia etc. there is good effect, to balanced human's diet nutritional, strengthen immune system and improve subhealth state and have extraordinary effect.
Lignum Aquilariae Resinatum, Classification system Aquilariaagallocha (Lour.) Roxb, it is the timber that Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum AquilariaSinensis (Lour.) Gilg contains resin that thymelaeceae class plant Lignum Aquilariae Resinatum belongs to.The whole year all can gather, and extracts resiniferous timber, removes not resiniferous part, dries in the shade.Lignum Aquilariae Resinatum is distributed in Hainan Province of China, Guangxi province, Fujian Province, and the ground such as Indonesia, Malaysia, Vietnam.Property is pungent, bitter, and taste temperature, returns spleen, stomach, kidney, lung meridian.Timber and resin, can supply small timber and fumet.Its black fragrance, fat is condensed into block, and entering water can sink, therefore claims " Lignum Aquilariae Resinatum " Lignum Aquilariae Resinatum, has another name called " lignum aquilariae resinatum ", " water precipitating is fragrant ", archaism writing " Shen Xiang " (Shen, with heavy).Since time immemorial " the imperial Moschus moschiferous of heavy wingceltis " often said it " sink ", just refer to Lignum Aquilariae Resinatum.The fragrant product of Lignum Aquilariae Resinatum are graceful, and very rare, are namely listed in since ancient times first of many perfume (or spice).
The acetone extract of Lignum Aquilariae Resinatum distills through saponification, obtains volatile oil 13%.Wherein contain benzylacetone, to methoxybenzyl benzylacetone etc., have 3-phenylpropionic acid in residue, to methoxyl group 3-phenylpropionic acid etc.Lignum Aquilariae Resinatum through fungal infection contains agarospirol (Agaro-spirol), linalool (Agarol), agarofuran (Agarofuran), dihydroagarofuran, 4-Hydroxydihydroagarofuran, 3,4-dihydroxy dihydroagarofurans, Nor-Ketoagarofuran (Nor-ketoaga-rofuran); Without the Lignum Aquilariae Resinatum sulfur-bearing, selinane (Selinane), linalool etc. of fungal infection.
Lignum Aquilariae Resinatum is containing volatile oil, wherein Sesquiterpene Polyesters: agarospirol, baimuxinic acid (baimuxinic acid), baimuxinal (baimuxinal), baimuxinol (baimu-xinol), dehydrobaimuxinol (dehydrobaimuxinol), Lignum Aquilariae Resinatum Furan Aldehydes (sinenofuranal), Lignum Aquilariae Resinatum furan alcohol (ainenofuranol), β-agarofuran, dihydro calacone, isobaimuxinol (isobaimuxinol).Also containing other volatile ingredients: benzylacetone, to methoxybenzyl benzylacetone, anisic acid (anisic acid).Again containing 2-(2-phenethyl) chromone constituents: 6-hydroxyl-2-(2-phenethyl) chromone [6-hydroxy-2-(2-phenylethyl) chromone] is namely AH3, 6-methoxyl group-2-(2-phenethyl) chromone [6-methoxy-2-(2-phenylethyl) chromone] is namely AH4, 6, 7-dimethoxy-2-(2-phenethyl) chromone [6, 7-dimethoxy-2-(2-phenylethyl) chromone] be namely AH5, { namely 6-methoxyl-2-[2-(3 '-methoxyphenyl) ethyl] chromone} is AHb1 to 6-methoxyl group-2-[2-(3'-methoxybenzene) ethyl] chromone, 2-(2-phenethyl) chromone [2-(2-phenylethyl) chromone] is namely AH8, 6-hydroxyl-2-[2-(4'-methoxybenzene) ethyl] chromone 6-hydroxy-2-[2-(4'-methoxyphenyl) ethyl] ethyl] chromone}, 5, 8-dihydroxy-2-(2-is to methoxyphenethyl) chromone { 5, 8-dihydroxy-2-[2-(p-methoxyphenyl) ethyl] chromone}, 6, 7-dimethoxy-2-(2-is to methoxyphenethyl) chromone { 6, 7-dimethoxy-2-[2-(p-methoxyphenyl) ethyl] chromone}, 5, 8-dihydroxy-2-(2-phenethyl) chromone [5, 8-dihydroxy-2-(2-phenylethyl) chromone].
Lignum Aquilariae Resinatum contains volatile oil containing Lignum Aquilariae Resinatum, wherein Sesquiterpene Polyesters has: agarospirol (agarospirol), linalool (agarol), Ramulus et Folium Gmelinae furan (gmelo-furan), a-and β-agarofuran (agarofuran), dihydroagarofuran (dihydroa-garofuran), Nor-Ketoagarofuran (nor-ketoagarofuran), 4-hydroxy dioxetane agarofuran (4-hydroxydihydroagarofuran), 3, 4-dihydroxy dioxy agarofuran (3, 4-dihydroxydihydroagarofuran), a-guaiene (a-guaiene), a-cloth Herba chenopodii alkene (a-bulnesene), withered tree alcohol (kusunol), calacone (karanone), dihydro calacone (dihydrokaranone), agarospirol aldehyde (oxoagarospirol), 1 (10), 11-guaiadiene-15-aldehyde [guaia-1 (10), 11-dien-15-al], 3, 11-celery diene-9-ketone (seline-3, 11-dien-9-one), 3, 11-celery diene-9-alcohol (seline-3, 11-dien-9-ol), the blue alcohol (jinkoheremol) of the refined sill of Lignum Aquilariae Resinatum etc.Also containing other volatile ingredients: benzylacetone (benzylacetone), to methoxybenzyl benzylacetone (P-methoxybenzylacetone), 3-phenylpropionic acid (hydrocinnamic acid) etc.; Again containing Lignum Aquilariae Resinatum quality (aquillochin), tulipiferine (liriodenine).Another containing 2-(2-phenethyl) chromone class [2-(2-phenylethyl) chromone] and dimer, trimer, composition: AH1, AH1a, AH2, AH2a, Ah2b, AH3, AH4, AH5, AH6, AH7, AH8, AH9, A10, AH11, AH12, AH13, AH14, AH15, AH16, AH17, AH18, AH19b, AH19b, AH20, AH23.Wherein AH1 is also called Lignum Aquilariae Resinatum tetrol (agarotetrol), and AH2 is also called different Lignum Aquilariae Resinatum tetrol (isoagarotetrol).
Lignum Aquilariae Resinatum wide variety and precious, repair the holy product of the best of holding for Buddhist, " Compendium of Materia Medica " records that Lignum Aquilariae Resinatum has strong antibacterial efficacy, fragrance enters spleen, clear god regulates the flow of vital energy, tonifying five ZANG-organs, relieving cough and resolving phlegm, warming the stomach warming the spleen, ventilation analgesic therapy, can be used as medicine, and is first-class medical material superfine product.Slightly warm in nature, acrid in the mouth, hardship.Sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.Promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.Be used for the treatment of the diseases such as the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.Consumption 1.5 ~ 4.5g, enter decoct should after under.Aquilaria sinensis (Lour.) Spreng., containing volatile oil and resin, containing agarospirol (Agarospirol) in volatile oil, has sedation.Medicinal effect with suppressing the hyperactive liver, the kidney warming improving inspiration by invigorating kidney-QI in promoting the circulation of QI to relieve pain, tune.Cure mainly: control QI rising in reverse order and pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.In addition Lignum Aquilariae Resinatum can sending down the abnormal ascending QI adjust in.It can easing stomach-QI, rises temper, warm in nature and not dry, benefaction and not letting out.So keep vomiting because cruelly eating the food of raw food when you, or suffer from cholera into sordid food can take Lignum Aquilariae Resinatum because eating.In addition, Lignum Aquilariae Resinatum or the healthy lucky star of old people, the easy constipation of old people, but long-term taking Lignum Aquilariae Resinatum can be avoided.If you feel dizziness and tinnitus because of being busy with one's work, lie awake all night, Lignum Aquilariae Resinatum also can help your fragrant and sweet sleep.Lignum Aquilariae Resinatum can be controlled QI rising in reverse order and pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.
Improve greatly although the living standard of modern society people is existing, because a variety of causes such as operating pressure is large etc., usually can cause that people's is depressed, depressed etc.Therefore, for people provide one can relieving stress and poor morale, antidepressant, improves the health-oriented products of the emotion of releiving of physical fatigue, is still that those skilled in the art extremely expect.
Summary of the invention
The object of the present invention is to provide a kind of compositions with antidepressant effect, expect said composition have at least one aspect such as of the present invention and the excellent properties of at least one aspect.The present invention have been surprisingly found that, the compositions with prescription feature of the present invention has obtained the character of at least one above-mentioned aspect.The present invention is based on this find and be accomplished.
For this reason, first aspect present invention provides a kind of compositions, and it is by the: Bai le, the Lepidinm meyenii Walp that comprise following active substance and make.
In arbitrary embodiment of either side of the present invention, when using Bai le, if not otherwise indicated, the dry product of its tender stem and leaf is all referred to.Certainly, when indicating, also its fresh goods can be used.No matter but be use fresh goods or dry product, when calculating its amount or relative quantity, be all in dry product.
In arbitrary embodiment of either side of the present invention, when using Lepidinm meyenii Walp, if not otherwise indicated, its dry product is all referred to.Certainly, when indicating, also its fresh goods can be used.No matter but be use fresh goods or dry product, when calculating its amount or relative quantity, be all in dry product.
In arbitrary embodiment of either side of the present invention, the various active substance of plant used, no matter they feed intake in what manner, when measuring, are all calculate with the dry product of these active substance of plant.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 10000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 7500 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 5000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 2000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 750 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 500 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 400 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 300 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 200 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 100 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 75 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 50 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 25 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 20 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 15 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 10 weight portion.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 10 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 15 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 20 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 25 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 50 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 75 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 100 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 200 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 300 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 400 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 500 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 750 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1000 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 2000 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 5000 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 7500 ~ 10000 weight portions.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 5 ~ 7500 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 10 ~ 5000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 15 ~ 2000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 20 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 25 ~ 750 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 30 ~ 500 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 35 ~ 400 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 40 ~ 300 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 45 ~ 200 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 50 ~ 150 weight portions.
Have been found that, when by Lepidinm meyenii Walp Yu when Bai le is with the ratio combination of first aspect present invention arbitrary embodiment, described compositions not only has excellent antidepressant effect, can be used for relieving stress, poor morale, emotion of releiving, and unexpectedly can improve the present invention and comprise in the compositions of Bai le, certain/some Bai le chemical composition (particularly Bai le flavonoids) stability in compositions Long-term Storage process.
In the present invention, if not otherwise indicated, measure the literature method (Cai Lingyun of method with reference to Cai Lingyun etc. of white le total flavones in the various compositions of the present invention, Deng Bai le leaf flavonoids extraction process and assay research, Chinese crude drug, the 10th phase in 2008), and particularly adopt in the document respectively with rutin and hyperin for index, adopt the method for the total flavones of ultraviolet spectrophotometry in 260nm place mensuration Bai le leaf to measure.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein said Bai le is that the form being broken into powder with its former Plant Powder is added in described compositions; Or described Bai le adds in described compositions through extracting extract obtained form with its former plant.In one embodiment, the extract of described Bai le is its water extract or ethanol extraction (also can be described as alcohol extract or ethanol extract in the present invention, such as 10 ~ 90% ethanol extractions).The preparation technology of term " water extract " or " alcohol extract " well known to a person skilled in the art, namely processes 1-5 time in a heated condition for Extraction solvent at the described water of use or ethanol, each 0.5 ~ 5 hour, gets extracting solution, concentrated, is drying to obtain.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein said Lepidinm meyenii Walp is that the form being broken into powder with its former Plant Powder is added in described compositions; Or described Lepidinm meyenii Walp adds in described compositions through extracting extract obtained form with its former plant.In one embodiment, the extract of described Lepidinm meyenii Walp is its water extract or ethanol extraction (also can be described as alcohol extract or ethanol extract in the present invention, such as 10 ~ 90% ethanol extractions).The preparation technology of term " water extract " or " alcohol extract " well known to a person skilled in the art, namely processes 1-5 time in a heated condition for Extraction solvent at the described water of use or ethanol, each 0.5 ~ 5 hour, gets extracting solution, concentrated, is drying to obtain.
The compositions of arbitrary embodiment according to a first aspect of the present invention, it is for antidepressant, relieving stress, poor morale, emotion of releiving.
The compositions of arbitrary embodiment according to a first aspect of the present invention, it places 5 months at 42 DEG C of temperature, and compared with 0 month, in said composition, white le total flavones loss is lower than 5.0%, particularly lower than 4.5%, particularly lower than 4.0%, particularly lower than 3.5%.Term “ Bai le total flavones loses " be calculated as follows:
White le total flavones loss=[in (in white le general flavone content in 0 month compositions-May compositions white le general flavone content) ÷ 0 month compositions in vain le general flavone content] × 100%
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein can also comprise Lignum Aquilariae Resinatum.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 750 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 500 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 200 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 100 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 75 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 50 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 40 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 30 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 20 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 10 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 7.5 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 5 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 2.5 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 2 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1.5 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1 weight portion.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.2 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.3 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.4 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.5 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.6 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.75 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 2 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 2.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 3 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 3.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 4 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 4.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 5 ~ 1000 weight portions.
The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 750 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.2 ~ 500 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.3 ~ 200 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.4 ~ 100 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.5 ~ 75 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.6 ~ 50 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.75 ~ 40 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1 ~ 30 weight portion.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1.5 ~ 20 weight portions.The compositions of arbitrary embodiment according to a first aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 2 ~ 15 weight portions.
Additionally, second aspect present invention provides a kind of compositions, and it is by comprising: Bai le that following active substance makes, Lignum Aquilariae Resinatum.
In arbitrary embodiment of either side of the present invention, when using Lignum Aquilariae Resinatum, if not otherwise indicated, its dry product is all referred to.Certainly, when indicating, also its fresh goods can be used.No matter but be use fresh goods or dry product, when calculating its amount or relative quantity, be all in dry product.
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 750 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 500 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 200 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 100 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 75 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 50 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 40 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 30 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 20 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 10 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 7.5 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 5 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 2.5 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 2 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1.5 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1 weight portion.
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.2 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.3 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.4 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.5 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.6 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.75 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 2 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 2.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 3 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 3.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 4 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 4.5 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 5 ~ 1000 weight portions.
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 750 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.2 ~ 500 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.3 ~ 200 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.4 ~ 100 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.5 ~ 75 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.6 ~ 50 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.75 ~ 40 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1 ~ 30 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 1.5 ~ 20 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 2 ~ 15 weight portions.
Have been found that, when by Lignum Aquilariae Resinatum Yu when Bai le is with the ratio combination of first aspect present invention arbitrary embodiment, described compositions not only has excellent antidepressant effect, can be used for relieving stress, poor morale, emotion of releiving, and unexpectedly can improve the present invention and comprise in the compositions of Bai le, certain/some Bai le chemical composition (particularly Bai le flavonoids) stability in compositions Long-term Storage process.
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein said Lignum Aquilariae Resinatum is that the form being broken into powder with its former Plant Powder is added in described compositions; Or described Lignum Aquilariae Resinatum is added in described compositions through extracting extract obtained form with its former plant.In one embodiment, the extract of described Lignum Aquilariae Resinatum is its water extract or ethanol extraction (also can be described as alcohol extract or ethanol extract in the present invention, such as 10 ~ 90% ethanol extractions).The preparation technology of term " water extract " or " alcohol extract " well known to a person skilled in the art, namely processes 1-5 time in a heated condition for Extraction solvent at the described water of use or ethanol, each 0.5 ~ 5 hour, gets extracting solution, concentrated, is drying to obtain.
The compositions of arbitrary embodiment according to a second aspect of the present invention, it is for antidepressant, relieving stress, poor morale, emotion of releiving.
The compositions of arbitrary embodiment according to a second aspect of the present invention, it places 5 months at 42 DEG C of temperature, and compared with 0 month, in said composition, white le total flavones loss is lower than 6.0%, particularly lower than 5.5%, particularly lower than 5.0%, particularly lower than 4.5%.Term “ Bai le total flavones loses " be calculated as follows:
White le total flavones loss=[in (in white le general flavone content in 0 month compositions-May compositions white le general flavone content) ÷ 0 month compositions in vain le general flavone content] × 100%
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein can also comprise Lepidinm meyenii Walp.
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 10000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 7500 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 5000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 2000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 1000 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 750 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 500 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 400 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 300 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 200 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 100 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 75 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 50 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 25 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 20 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 15 weight portion.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 10 weight portion.
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 10 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 15 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 20 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 25 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 50 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 75 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 100 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 200 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 300 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 400 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 500 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 750 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1000 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 2000 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 5000 ~ 10000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 7500 ~ 10000 weight portions.
The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 5 ~ 7500 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 10 ~ 5000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 15 ~ 2000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 20 ~ 1000 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 25 ~ 750 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 30 ~ 500 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 35 ~ 400 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 40 ~ 300 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 45 ~ 200 weight portions.The compositions of arbitrary embodiment according to a second aspect of the present invention, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 50 ~ 150 weight portions.
According to the compositions of the arbitrary embodiment of either side of the present invention, it is the dosage form used in suitable for oral administration.Described dosage form is such as but not limited to: medicated wine, beverage (such as herbal tea), tablet, capsule, unguentum (such as with brown sugar, Colla Corii Asini, the kyphosis for substrate), solid beverage (such as electuary, powder etc.) etc.Preparing these dosage forms is that this area such as field of food or pharmaceutical field technical staff are known.And when preparing these dosage forms, usually can also add on food or pharmaceutically acceptable adjuvant.
According to the compositions of the arbitrary embodiment of either side of the present invention, wherein also comprise on food or pharmaceutically acceptable adjuvant.Term " adjuvant " refers to and to add to compositions be made suitable product form, and does not usually have physiological functional activity.Notoriously, the adjuvant kind that different product forms is selected is likely different.Such as medicated wine, its main adjuvant is wine, comprises various forms of beverage wine, such as Chinese liquor, yellow wine or foreign wine; Now, the amount of described active substance total amount in this medicated wine can be 1 ~ 50%, such as 1 ~ 40%, such as 1 ~ 30%, such as 1 ~ 20%, such as 1 ~ 10% usually.Such as beverage, its main adjuvant is water; Now, described active substance total amount amount in the beverage can be 1 ~ 50%, such as 1 ~ 40%, such as 1 ~ 30%, such as 1 ~ 20%, such as 1 ~ 10% usually.The contribution of the present invention to present technology is to find Lepidinm meyenii Walp and/or Lignum Aquilariae Resinatum Yu Bai le combines, in antidepressant, relieving stress, poor morale and/or releive outside the function of emotion when have been surprisingly found that being used alone far above them not only appears in this combination, also find the stability that this combination can improve the present invention and comprises the composition product Zhong Bai le total flavones of Bai le.That is, the present invention to the contribution of prior art be not depend on these adjuvant existence whether (although when they are present in the present composition be favourable for the convenience orally used).Therefore, essence of the present invention is to find that above-mentioned Lepidinm meyenii Walp and/or Lignum Aquilariae Resinatum are Yu Bai le combines.
Further, third aspect present invention provides compositions described in first aspect present invention or the arbitrary embodiment of second aspect for the preparation of antidepressant, relieving stress, poor morale and/or the purposes of releiving in the product of emotion.
Further, fourth aspect present invention provides the stable method of the product that is used in antidepressant, relieving stress, poor morale and/or emotion of releiving, described product comprises active substance Bai le, and this product is placed 5 months at 42 DEG C of temperature, compared with 0 month, in said composition, white le total flavones loss is lower than 5.0%, particularly lower than 4.5%, particularly lower than 4.0%, particularly lower than 3.5%; Or this product is placed 5 months at 42 DEG C of temperature, compared with 0 month, in this product, white le total flavones loss is lower than 6.0%, particularly lower than 5.5%, particularly lower than 5.0%, particularly lower than 4.5%.
Method according to a fourth aspect of the present invention, wherein said product has the feature of compositions as described in embodiment as arbitrary in first aspect present invention.
Method according to a fourth aspect of the present invention, wherein said product has the feature of compositions as described in embodiment as arbitrary in second aspect present invention.
Detailed description of the invention
The following examples provided only for task of explanation instead of for, should not be interpreted as limiting the present invention by any way yet.Those skilled in the art will recognize that can make routine to following examples when not surmounting the spirit or scope of the present invention changes and amendment.
In instantiation below, if not otherwise specified, the white le used be the dry product of its tender stem and leaf through powder pulverized powder, the Lepidinm meyenii Walp used be dry product through powder pulverized powder, the Lignum Aquilariae Resinatum used is that dry product is through powder pulverized powder.
In instantiation below, if not otherwise specified, use Bai le water extract Shi Bai le water and extract 3 times in a heated condition, each 1 hour, get extracting solution, concentrated, the extract of dry gained; Use Bai le ethanol extraction Shi Bai le 70% ethanol and extract 3 times in a heated condition, each 1 hour, get extracting solution, concentrated, the extract of dry gained.In instantiation below, if not otherwise specified, the Lepidinm meyenii Walp water extract used is that Lepidinm meyenii Walp water extracts 3 times in a heated condition, each 1 hour, gets extracting solution, concentrated, the extract of dry gained; The Lepidinm meyenii Walp ethanol extraction used is that Lepidinm meyenii Walp 70% ethanol extracts 3 times in a heated condition, each 1 hour, gets extracting solution, concentrated, the extract of dry gained.In instantiation below, if not otherwise specified, the Lignum Aquilariae Resinatum water extract used is that Lignum Aquilariae Resinatum use water extracts 3 times in a heated condition, each 1 hour, gets extracting solution, concentrated, the extract of dry gained; The Lignum Aquilariae Resinatum ethanol extraction used is that Lignum Aquilariae Resinatum 70% ethanol extracts 3 times in a heated condition, each 1 hour, gets extracting solution, concentrated, the extract of dry gained.No matter feeding intake in what manner, when measuring, is all calculate with the dry product of these active substance of plant.
In the following embodiments, if not otherwise indicated, when each material represents with weight portion, compositions amount of preparation Yi Bai le inventory counts 100g/ batch.In the following embodiments, if not otherwise indicated, when feeding intake, each material is ground into the powder by 80 mesh sieves all in advance.
one, compositions preparation example part
Embodiment 1: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 1 weight portion.Bai le and Lepidinm meyenii Walp with the abundant mix homogeneously of its powder, to obtain final product by method for making:.
Embodiment 2: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 10000 weight portion.Method for making: with reference to embodiment 1.
Embodiment 3: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 7500 weight portion.Method for making: with reference to embodiment 1.
Embodiment 4: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 5000 weight portion.Method for making: with reference to embodiment 1.
Embodiment 5: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 2000 weight portion.Method for making: with reference to embodiment 1.
Embodiment 6: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 1000 weight portion.Method for making: with reference to embodiment 1.
Embodiment 7: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 750 weight portion.Method for making: with reference to embodiment 1.
Embodiment 8: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 500 weight portion.Method for making: with reference to embodiment 1.
Embodiment 9: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 400 weight portion.Method for making: with reference to embodiment 1.
Embodiment 10: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 300 weight portion.Method for making: with reference to embodiment 1.
Embodiment 11: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 200 weight portion.Method for making: with reference to embodiment 1.
Embodiment 12: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion.Method for making: with reference to embodiment 1.
Embodiment 13: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 75 weight portion.Method for making: with reference to embodiment 1.
Embodiment 14: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 50 weight portion.Method for making: with reference to embodiment 1.
Embodiment 15: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 25 weight portion.Method for making: with reference to embodiment 1.
Embodiment 16: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 20 weight portion.Method for making: with reference to embodiment 1.
Embodiment 17: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 15 weight portion.Method for making: with reference to embodiment 1.
Embodiment 18: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 10 weight portion.Method for making: with reference to embodiment 1.
Embodiment 19: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 5 weight portion.Method for making: with reference to embodiment 1.
Embodiment 20: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 30 weight portion.Method for making: with reference to embodiment 1.
Embodiment 21: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 35 weight portion.Method for making: with reference to embodiment 1.
Embodiment 22: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 40 weight portion.Method for making: with reference to embodiment 1.
Embodiment 23: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 45 weight portion.Method for making: with reference to embodiment 1.
Embodiment 24: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.1 weight portion.Bai le, Lepidinm meyenii Walp, Lignum Aquilariae Resinatum with the abundant mix homogeneously of its powder, to obtain final product by method for making:.
Embodiment 25: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 1000 weight portion.Method for making: with reference to embodiment 24.
Embodiment 26: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 750 weight portion.Method for making: with reference to embodiment 24.
Embodiment 27: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 500 weight portion.Method for making: with reference to embodiment 24.
Embodiment 28: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 200 weight portion.Method for making: with reference to embodiment 24.
Embodiment 29: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 100 weight portion.Method for making: with reference to embodiment 24.
Embodiment 30: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 75 weight portion.Method for making: with reference to embodiment 24.
Embodiment 31: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 50 weight portion.Method for making: with reference to embodiment 24.
Embodiment 32: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 40 weight portion.Method for making: with reference to embodiment 24.
Embodiment 33: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 30 weight portion.Method for making: with reference to embodiment 24.
Embodiment 34: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 20 weight portion.Method for making: with reference to embodiment 24.
Embodiment 35: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 10 weight portion.Method for making: with reference to embodiment 24.
Embodiment 36: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 7.5 weight portion.Method for making: with reference to embodiment 24.
Embodiment 37: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion.Method for making: with reference to embodiment 24.
Embodiment 38: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 2.5 weight portion.Method for making: with reference to embodiment 24.
Embodiment 39: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 2 weight portion.Method for making: with reference to embodiment 24.
Embodiment 40: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 1.5 weight portion.Method for making: with reference to embodiment 24.
Embodiment 41: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 1 weight portion.Method for making: with reference to embodiment 24.
Embodiment 42: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.15 weight portion.Method for making: with reference to embodiment 24.
Embodiment 43: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.2 weight portion.Method for making: with reference to embodiment 24.
Embodiment 44: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.3 weight portion.Method for making: with reference to embodiment 24.
Embodiment 45: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.4 weight portion.Method for making: with reference to embodiment 24.
Embodiment 46: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.5 weight portion.Method for making: with reference to embodiment 24.
Embodiment 47: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.6 weight portion.Method for making: with reference to embodiment 24.
Embodiment 48: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 0.75 weight portion.Method for making: with reference to embodiment 24.
Embodiment 49: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 3 weight portion.Method for making: with reference to embodiment 24.
Embodiment 50: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 3.5 weight portion.Method for making: with reference to embodiment 24.
Embodiment 51: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 4 weight portion.Method for making: with reference to embodiment 24.
Embodiment 52: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 4.5 weight portion.Method for making: with reference to embodiment 24.
Embodiment 53: prepared by compositions
Formula: Bai le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, Lignum Aquilariae Resinatum 15 weight portion.Method for making: with reference to embodiment 24.
Embodiment 101: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.1 weight portion.Bai le, Lignum Aquilariae Resinatum with the abundant mix homogeneously of its powder, to obtain final product by method for making:.
Embodiment 102: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 1000 weight portion.Method for making: with reference to embodiment 101.
Embodiment 103: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 750 weight portion.Method for making: with reference to embodiment 101.
Embodiment 104: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 500 weight portion.Method for making: with reference to embodiment 101.
Embodiment 105: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 200 weight portion.Method for making: with reference to embodiment 101.
Embodiment 106: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 100 weight portion.Method for making: with reference to embodiment 101.
Embodiment 107: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 75 weight portion.Method for making: with reference to embodiment 101.
Embodiment 108: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 50 weight portion.Method for making: with reference to embodiment 101.
Embodiment 109: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 40 weight portion.Method for making: with reference to embodiment 101.
Embodiment 110: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 30 weight portion.Method for making: with reference to embodiment 101.
Embodiment 111: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 20 weight portion.Method for making: with reference to embodiment 101.
Embodiment 112: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 10 weight portion.Method for making: with reference to embodiment 101.
Embodiment 113: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 7.5 weight portion.Method for making: with reference to embodiment 101.
Embodiment 114: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion.Method for making: with reference to embodiment 101.
Embodiment 115: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 2.5 weight portion.Method for making: with reference to embodiment 101.
Embodiment 116: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 2 weight portion.Method for making: with reference to embodiment 101.
Embodiment 117: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 1.5 weight portion.Method for making: with reference to embodiment 101.
Embodiment 118: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 1 weight portion.Method for making: with reference to embodiment 101.
Embodiment 119: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.15 weight portion.Method for making: with reference to embodiment 101.
Embodiment 120: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.2 weight portion.Method for making: with reference to embodiment 101.
Embodiment 121: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.3 weight portion.Method for making: with reference to embodiment 101.
Embodiment 122: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.4 weight portion.Method for making: with reference to embodiment 101.
Embodiment 123: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.5 weight portion.Method for making: with reference to embodiment 101.
Embodiment 124: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.6 weight portion.Method for making: with reference to embodiment 101.
Embodiment 125: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 0.75 weight portion.Method for making: with reference to embodiment 101.
Embodiment 126: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 3 weight portion.Method for making: with reference to embodiment 101.
Embodiment 127: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 3.5 weight portion.Method for making: with reference to embodiment 101.
Embodiment 128: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 4 weight portion.Method for making: with reference to embodiment 101.
Embodiment 129: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 4.5 weight portion.Method for making: with reference to embodiment 101.
Embodiment 130: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 1 weight portion.Bai le, Lignum Aquilariae Resinatum, Lepidinm meyenii Walp with the abundant mix homogeneously of its powder, to obtain final product by method for making:.
Embodiment 131: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 10000 weight portion.Method for making: with reference to embodiment 130.
Embodiment 132: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 7500 weight portion.Method for making: with reference to embodiment 130.
Embodiment 133: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 5000 weight portion.Method for making: with reference to embodiment 130.
Embodiment 134: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 2000 weight portion.Method for making: with reference to embodiment 130.
Embodiment 135: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 1000 weight portion.Method for making: with reference to embodiment 130.
Embodiment 136: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 750 weight portion.Method for making: with reference to embodiment 130.
Embodiment 137: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 500 weight portion.Method for making: with reference to embodiment 130.
Embodiment 138: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 400 weight portion.Method for making: with reference to embodiment 130.
Embodiment 139: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 300 weight portion.Method for making: with reference to embodiment 130.
Embodiment 140: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 200 weight portion.Method for making: with reference to embodiment 130.
Embodiment 141: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 100 weight portion.Method for making: with reference to embodiment 130.
Embodiment 142: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 75 weight portion.Method for making: with reference to embodiment 130.
Embodiment 143: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 50 weight portion.Method for making: with reference to embodiment 130.
Embodiment 144: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 25 weight portion.Method for making: with reference to embodiment 130.
Embodiment 145: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 20 weight portion.Method for making: with reference to embodiment 130.
Embodiment 146: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 15 weight portion.Method for making: with reference to embodiment 130.
Embodiment 147: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 10 weight portion.Method for making: with reference to embodiment 130.
Embodiment 148: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 5 weight portion.Method for making: with reference to embodiment 130.
Embodiment 149: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 30 weight portion.Method for making: with reference to embodiment 130.
Embodiment 150: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 35 weight portion.Method for making: with reference to embodiment 130.
Embodiment 151: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 40 weight portion.Method for making: with reference to embodiment 130.
Embodiment 152: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 45 weight portion.Method for making: with reference to embodiment 130.
Embodiment 153: prepared by compositions
Formula: Bai le 100 weight portion, Lignum Aquilariae Resinatum 5 weight portion, Lepidinm meyenii Walp 150 weight portion.Method for making: with reference to embodiment 130.
Embodiment 201: prepared by compositions
Formula: with embodiment 1, but use Bai le water extract, Lepidinm meyenii Walp water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 202: prepared by compositions
Formula: with embodiment 2, but use Bai le water extract, Lepidinm meyenii Walp water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 203: prepared by compositions
Formula: with embodiment 1, but use Bai le alcohol extract, Lepidinm meyenii Walp alcohol extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 204: prepared by compositions
Formula: with embodiment 2, but use Bai le water extract, Lepidinm meyenii Walp alcohol extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 205: prepared by compositions
Formula: with embodiment 12, but use Bai le alcohol extract, Lepidinm meyenii Walp alcohol extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 206: prepared by compositions
Formula: with embodiment 12, but use Bai le water extract, Lepidinm meyenii Walp water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 207: prepared by compositions
Formula: with embodiment 12, but use Bai le alcohol extract, Lepidinm meyenii Walp water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 208: prepared by compositions
Formula: with embodiment 39, but use Bai le water extract, Lepidinm meyenii Walp water extract, Lignum Aquilariae Resinatum water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 209: prepared by compositions
Formula: with embodiment 39, but use Bai le water extract, Lepidinm meyenii Walp alcohol extract, Lignum Aquilariae Resinatum water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 210: prepared by compositions
Formula: with embodiment 39, but use Bai le alcohol extract, Lepidinm meyenii Walp water extract, linalool extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 211: prepared by compositions
Formula: with embodiment 101, but use Bai le alcohol extract, linalool extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 212: prepared by compositions
Formula: with embodiment 101, but use Bai le water extract, Lignum Aquilariae Resinatum water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 213: prepared by compositions
Formula: with embodiment 102, but use Bai le alcohol extract, linalool extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 214: prepared by compositions
Formula: with embodiment 102, but use Bai le water extract, Lignum Aquilariae Resinatum water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 215: prepared by compositions
Formula: with embodiment 114, but use Bai le alcohol extract, linalool extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 216: prepared by compositions
Formula: with embodiment 114, but use Bai le alcohol extract, Lignum Aquilariae Resinatum water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 217: prepared by compositions
Formula: with embodiment 114, but use Bai le water extract, linalool extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 218: prepared by compositions
Formula: with embodiment 114, but use Bai le water extract, Lignum Aquilariae Resinatum water extract.
Method for making: by each extract mix homogeneously, to obtain final product.
Embodiment 219: prepared by compositions
Formula is with embodiment 12, i.e. white le 100 weight portion, Lepidinm meyenii Walp 100 weight portion, 45% degree of Chinese liquor of additional 800 weight portions, makes medicated wine by the method for making of medicated wine.
Embodiment 220: prepared by compositions
Formula is with embodiment 208, and use three kinds of water extract, the water of additional 8000 weight portions, makes beverage by well-established law.
Embodiment 221: prepared by compositions
Formula is with embodiment 215, and use two kinds of alcohol extracts, additional 500 weight starch, 500 weight portion dextrin, make mixed-powder by well-established law, encapsulated, become capsule, and every Han Bai le is in medical material 0.25g.[in addition, can be wetting agent soft material by this mixed-powder water, granulate, dry, adding dry particle weight 0.5% magnesium stearate be lubricant, and mix homogeneously, is pressed into tablet by well-established law, and every sheet contains white le in medical material 0.25g].
Two, compositions chemical property is investigated
By whole compositionss prepared by above embodiment 1-embodiment 221, with vial sealing, place 5 months under putting 42 DEG C of temperature.Measure 0 month and general flavone content in each compositions during May, then calculate each compositions white le total flavones loss (%) amount before and after this high-temperature process of experience.Result shows, whole compositions Bai le total flavones loss is all lower than 5.0%, particularly, for the compositions that both only You Bai le and Lepidinm meyenii Walp are obtained, and the compositions that You Bai le, Lepidinm meyenii Walp, Lignum Aquilariae Resinatum three obtain, their Bai le total flavones lose all lower than 3.5%, all in 1.3 ~ 3.4% scopes; And for the obtained compositions of both only You Bai le and Lignum Aquilariae Resinatum, the loss of their Bai le total flavones all lower than 4.5%, all in 1.6 ~ 4.3% scopes.In addition, the method of to place at 42 DEG C of temperature 5 months is put according to above-mentioned, dispose the loss of Bai le dry product, Bai le water extract, Bai le alcohol extract Bai le total flavones respectively, the loss of result display three Bai le total flavones is all in 16.3 ~ 22.7% scopes, and such as the loss of Bai le dry product Bai le total flavones is 16.3%.The display of above result, when Bai le combine with Lepidinm meyenii Walp and/or Lignum Aquilariae Resinatum, can Shi Bai le chemical stability maintenance better.
Three, the biological property of compositions is investigated
Use evaluation product classical clinically to antidepressant below, relieving stress, poor morale, the method of emotion of releiving effect, investigate the embodiment of the present invention 12, embodiment 39, embodiment 114, embodiment 205, embodiment 208, (six dosage are 5g/ days in Bai le to embodiment 217 6 kinds of compositionss, once a day, be used in conjunction 6 weeks), (dosage is 10g/ days in Bai le to Bai le, once a day, be used in conjunction 6 weeks), (dosage is 10g/ days in Lepidinm meyenii Walp to Lepidinm meyenii Walp, once a day, be used in conjunction 6 weeks), (dosage is 0.5g/ days in Lignum Aquilariae Resinatum to Lignum Aquilariae Resinatum, once a day, be used in conjunction 6 weeks) biologic activity of totally nine kinds.
Choose body weight 60Kg ± 5Kg, there is depressive emotion, insomnia does not have enough sleep 3 hours (total sleep time was lower than 21 hours (all between 14 ~ 21 hours) weekly) every day, initiatively do not go out voluntary trier 135 people of (weekly initiatively outdoor activity number of times lower than 12 times (all between 6 ~ 12 times)), be divided into 9 groups, often organize 15 people, corresponding product is taken between every morning 9-10 point, take six weeks continuously, and record last week outdoor activity number of times and the length of one's sleep, to carry out efficacy assessment, result is as shown in table 1:
Table 1: trier's outdoor activity number of times and the length of one's sleep (representing with average)
| Group | The active outdoor activity number of times in last week | The length of one's sleep in last week |
| Embodiment 12 | 38 times | 40 hours |
| Embodiment 39 | 35 times | 42 hours |
| Embodiment 114 | 41 times | 44 hours |
| Embodiment 205 | 37 times | 45 hours |
| Embodiment 208 | 42 times | 41 hours |
| Embodiment 217 | 40 times | 39 hours |
| Bai le | 14 times | 25 hours |
| Lepidinm meyenii Walp | 13 times | 19 hours |
| Lignum Aquilariae Resinatum | 11 times | 21 hours |
Two evaluation indexes of the experimenter of alone three kinds of materials and basic value are quite or micro-high above, show that three kinds of materials are all substantially invalid.
In addition, find in extra complementary testing, on the basis of the present composition, add other material again, no matter be that there is the medicinal of biologic activity or edible materials, or do not have an adjuvant of biologic activity, all do not affect above the performance of the present composition stability described in " two, compositions chemical property investigate ", also all do not affect above the biological performance of the present composition described in " three, the biological property of compositions investigate ", namely the present invention finds by the impact whether other material adds.
Industrial applicability
The invention provides the excellent efficacy that a kind of compositions, particularly said composition with superior bio activity has antidepressant, relieving stress, poor morale, emotion of releiving.
Although present invention has been description to a certain degree, significantly, under the condition not departing from the spirit and scope of the present invention, can carry out the suitable change of each condition.Be appreciated that and the invention is not restricted to described embodiment, and be attributed to the scope of claim, it comprises the equivalent replacement of described each factor.
Claims (10)
1. a compositions, it is made by comprising following active substance: white le, Lepidinm meyenii Walp.
2. compositions according to claim 1, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 10000 weight portion, or 1 ~ 7500 weight portion, or 1 ~ 5000 weight portion, or 1 ~ 2000 weight portion, or 1 ~ 1000 weight portion, or 1 ~ 750 weight portion, or 1 ~ 500 weight portion, or 1 ~ 400 weight portion, or 1 ~ 300 weight portion, or 1 ~ 200 weight portion, or 1 ~ 100 weight portion, or 1 ~ 75 weight portion, or 1 ~ 50 weight portion, or 1 ~ 25 weight portion, or 1 ~ 20 weight portion, or 1 ~ 15 weight portion, or 1 ~ 10 weight portion; Or
In every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 10 ~ 10000 weight portions, or 15 ~ 10000 weight portions, or 20 ~ 10000 weight portions, or 25 ~ 10000 weight portions, or 50 ~ 10000 weight portions, or 75 ~ 10000 weight portions, or 100 ~ 10000 weight portions, or 200 ~ 10000 weight portions, or 300 ~ 10000 weight portions, or 400 ~ 10000 weight portions, or 500 ~ 10000 weight portions, or 750 ~ 10000 weight portions, or 1000 ~ 10000 weight portions, or 2000 ~ 10000 weight portions, or 5000 ~ 10000 weight portions, or 7500 ~ 10000 weight portions; Or
In every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 5 ~ 7500 weight portions, or 10 ~ 5000 weight portions, or 15 ~ 2000 weight portions, or 20 ~ 1000 weight portions, or 25 ~ 750 weight portions, or 30 ~ 500 weight portions, or 35 ~ 400 weight portions, or 40 ~ 300 weight portions, or 45 ~ 200 weight portions, or 50 ~ 150 weight portions.
3. compositions according to claim 1, it is for antidepressant, relieving stress, poor morale, emotion of releiving; Or it places 5 months at 42 DEG C of temperature, compared with 0 month, in said composition, white le total flavones loss is lower than 5.0%, particularly lower than 4.5%, particularly lower than 4.0%, particularly lower than 3.5%.
4. compositions according to claim 1, wherein can also comprise Lignum Aquilariae Resinatum; Further, in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1000 weight portion, or 0.1 ~ 750 weight portion, or 0.1 ~ 500 weight portion, or 0.1 ~ 200 weight portion, or 0.1 ~ 100 weight portion, or 0.1 ~ 75 weight portion, or 0.1 ~ 50 weight portion, or 0.1 ~ 40 weight portion, or 0.1 ~ 30 weight portion, or 0.1 ~ 20 weight portion, or 0.1 ~ 10 weight portion, or 0.1 ~ 7.5 weight portion, or 0.1 ~ 5 weight portion, or 0.1 ~ 2.5 weight portion, or 0.1 ~ 2 weight portion, or 0.1 ~ 1.5 weight portion, or 0.1 ~ 1 weight portion; Or
Wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 1000 weight portion, or 0.2 ~ 1000 weight portion, or 0.3 ~ 1000 weight portion, or 0.4 ~ 1000 weight portion, or 0.5 ~ 1000 weight portion, or 0.6 ~ 1000 weight portion, or 0.75 ~ 1000 weight portion, or 1 ~ 1000 weight portion, or 1.5 ~ 1000 weight portions, or 2 ~ 1000 weight portions, or 2.5 ~ 1000 weight portions, or 3 ~ 1000 weight portions, or 3.5 ~ 1000 weight portions, or 4 ~ 1000 weight portions, or 4.5 ~ 1000 weight portions, or 5 ~ 1000 weight portions; Or
Wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 750 weight portion, or 0.2 ~ 500 weight portion, or 0.3 ~ 200 weight portion, or 0.4 ~ 100 weight portion, or 0.5 ~ 75 weight portion, or 0.6 ~ 50 weight portion, or 0.75 ~ 40 weight portion, or 1 ~ 30 weight portion, or 1.5 ~ 20 weight portions, or 2 ~ 15 weight portions.
5. a compositions, it is made by comprising following active substance: white le, Lignum Aquilariae Resinatum; Further,
In every 100 weight portion Bai le in said composition, the amount of Lignum Aquilariae Resinatum is 0.1 ~ 1000 weight portion, or 0.1 ~ 750 weight portion, or 0.1 ~ 500 weight portion, or 0.1 ~ 200 weight portion, or 0.1 ~ 100 weight portion, or 0.1 ~ 75 weight portion, or 0.1 ~ 50 weight portion, or 0.1 ~ 40 weight portion, or 0.1 ~ 30 weight portion, or 0.1 ~ 20 weight portion, or 0.1 ~ 10 weight portion, or 0.1 ~ 7.5 weight portion, or 0.1 ~ 5 weight portion, or 0.1 ~ 2.5 weight portion, or 0.1 ~ 2 weight portion, or 0.1 ~ 1.5 weight portion, or 0.1 ~ 1 weight portion; Or
Wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 1000 weight portion, or 0.2 ~ 1000 weight portion, or 0.3 ~ 1000 weight portion, or 0.4 ~ 1000 weight portion, or 0.5 ~ 1000 weight portion, or 0.6 ~ 1000 weight portion, or 0.75 ~ 1000 weight portion, or 1 ~ 1000 weight portion, or 1.5 ~ 1000 weight portions, or 2 ~ 1000 weight portions, or 2.5 ~ 1000 weight portions, or 3 ~ 1000 weight portions, or 3.5 ~ 1000 weight portions, or 4 ~ 1000 weight portions, or 4.5 ~ 1000 weight portions, or 5 ~ 1000 weight portions; Or
Wherein in every 100 weight portion Bai le, the amount of Lignum Aquilariae Resinatum is 0.15 ~ 750 weight portion, or 0.2 ~ 500 weight portion, or 0.3 ~ 200 weight portion, or 0.4 ~ 100 weight portion, or 0.5 ~ 75 weight portion, or 0.6 ~ 50 weight portion, or 0.75 ~ 40 weight portion, or 1 ~ 30 weight portion, or 1.5 ~ 20 weight portions, or 2 ~ 15 weight portions.
6. compositions according to claim 5, it is for antidepressant, relieving stress, poor morale, emotion of releiving; Or it places 5 months at 42 DEG C of temperature, compared with 0 month, in said composition, white le total flavones loss is lower than 6.0%, particularly lower than 5.5%, particularly lower than 5.0%, particularly lower than 4.5%.
7. compositions according to claim 5, wherein can also comprise Lepidinm meyenii Walp; Further, wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 1 ~ 10000 weight portion, or 1 ~ 7500 weight portion, or 1 ~ 5000 weight portion, or 1 ~ 2000 weight portion, or 1 ~ 1000 weight portion, or 1 ~ 750 weight portion, or 1 ~ 500 weight portion, or 1 ~ 400 weight portion, or 1 ~ 300 weight portion, or 1 ~ 200 weight portion, or 1 ~ 100 weight portion, or 1 ~ 75 weight portion, or 1 ~ 50 weight portion, or 1 ~ 25 weight portion, or 1 ~ 20 weight portion, or 1 ~ 15 weight portion, or 1 ~ 10 weight portion; Or
Wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 10 ~ 10000 weight portions, or 15 ~ 10000 weight portions, or 20 ~ 10000 weight portions, or 25 ~ 10000 weight portions, or 50 ~ 10000 weight portions, or 75 ~ 10000 weight portions, or 100 ~ 10000 weight portions, or 200 ~ 10000 weight portions, or 300 ~ 10000 weight portions, or 400 ~ 10000 weight portions, or 500 ~ 10000 weight portions, or 750 ~ 10000 weight portions, or 1000 ~ 10000 weight portions, or 2000 ~ 10000 weight portions, or 5000 ~ 10000 weight portions, or 7500 ~ 10000 weight portions, or
Wherein in every 100 weight portion Bai le, the amount of Lepidinm meyenii Walp is 5 ~ 7500 weight portions, or 10 ~ 5000 weight portions, or 15 ~ 2000 weight portions, or 20 ~ 1000 weight portions, or 25 ~ 750 weight portions, or 30 ~ 500 weight portions, or 35 ~ 400 weight portions, or 40 ~ 300 weight portions, or 45 ~ 200 weight portions, or 50 ~ 150 weight portions.
8., according to the compositions of any one of claim 1-7, it is the dosage form used in suitable for oral administration; Further, described dosage form is such as but not limited to: medicated wine, beverage (such as herbal tea), tablet, capsule, unguentum (such as with brown sugar, Colla Corii Asini, the kyphosis for substrate), solid beverage (such as electuary, powder etc.) etc.; Further, wherein also comprise on food or pharmaceutically acceptable adjuvant.
9. the compositions of any one of claim 1-7 is for the preparation of antidepressant, relieving stress, poor morale and/or the purposes of releiving in the product of emotion.
10. be used in the method that the product of antidepressant, relieving stress, poor morale and/or emotion of releiving is stable, described product comprises active substance Bai le, and this product is placed 5 months at 42 DEG C of temperature, compared with 0 month, the loss of said composition Zhong Bai le total flavones is lower than 5.0%, particularly lower than 4.5%, particularly lower than 4.0%, particularly lower than 3.5%; Or this product is placed 5 months at 42 DEG C of temperature, compared with 0 month, in this product, white le total flavones loss is lower than 6.0%, particularly lower than 5.5%, particularly lower than 5.0%, particularly lower than 4.5%; Further, described product has the feature of compositions as described in any one of claim 1-7.
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| CN104905245A (en) * | 2015-03-12 | 2015-09-16 | 苏其远 | A composite Chinese herbal medicine cigarette-shaped health-care product |
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Effective date of registration: 20200831 Address after: Room 207B, second floor, No.4 factory building, science and Technology Park, South China Modern Chinese medicine city, Nanlang Town, Zhongshan City, Guangdong Province 528400 Patentee after: One health biotechnology (Guangdong) Co., Ltd Address before: 528402, room 15, 503 Dongming Road, Dongming garden, Shiqi District, Guangdong, Zhongshan, China Patentee before: Li Chenyue |
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