CN104689465A - Vacuum negative pressure ultrasonic transdermal drug delivery device - Google Patents
Vacuum negative pressure ultrasonic transdermal drug delivery device Download PDFInfo
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- CN104689465A CN104689465A CN201510115751.2A CN201510115751A CN104689465A CN 104689465 A CN104689465 A CN 104689465A CN 201510115751 A CN201510115751 A CN 201510115751A CN 104689465 A CN104689465 A CN 104689465A
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- negative pressure
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- transdermal delivery
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Abstract
A vacuum negative pressure ultrasonic transdermal drug delivery device is composed of a negative pressure unit for generating dermal negative pressure suction and an air pumping bag for generating negative pressure in the negative pressure unit. The air pumping bag and the negative pressure unit are in fixed connection through a thread. The top of the air pumping bag is provided with an air pumping check valve and a valve fixing tube for fixing the air pumping check valve. An ultrasound unit acting on the human body is arranged in the negative pressure unit. The vacuum negative pressure ultrasonic transdermal drug delivery device has the advantages of being tight in drug delivery space, achieving the effects of dermal looseness, intradermal congestion, epidermis stratum corneum fracture, keratinocyte gap increasing and obvious skin resistance decreasing through the action of negative pressure and providing transdermal drug delivery power for a drug under the ultrasonic stimulation, thereby improving the transdermal efficiency of the drug, increasing the transdermal penetration amount of the drug and enhancing the therapeutic effect accordingly.
Description
Technical field
The present invention designs ultrasonic therapeutic field, specifically the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum.
Background technology
Percutaneous dosing is a kind of new way of non-invasive administration, and medicine, by after the method transdermal of percutaneous dosing, enters the therapeutic modality of blood circulation and a therapeutical effect.Percutaneous dosing treatment has the particular advantages surmounting general administration, can destroy without " first pass effect " of liver and gastrointestinal, especially toxicity or the larger medicine of zest injure gastrointestinal tract to avoid oral drugs, also avoid the decomposition of effective ingredient to destroy simultaneously, side effect is little, is a kind of effective way of disease therapy.But skin is the natural cover for defense of human body, there is very careful structure, medicine is hindered to enter in body, drugs through skin is subject to sizable resistance, most medicine not easily passes human body skin, and this is effective, and optionally barrier, is difficult to the dosage making medicine reach required, how to apply potent safe transdermal and urge permeating method, play better drug effect is be the focus studied for many years always.
Negative pressure device is through being usually used in health care, it acts on skin surface, by formation vacuum negative pressure condition of bleeding, can make that effect skin surface is loose, density reductions, capillary rupture, Intradermal hyperemia, epidermal keratinocytes fault rupture, the increase of horn cell gap, on this basis, can promote that medicinal liquid absorbs, strengthen administering effect.
Ultrasonic percutaneous dosing technology is the one of physical enhancement method, and compared with other physical aproach to enhancing penetrations, it is all relatively high that ultrasound wave urgees milliosmolarity, the drug osmotic degree of depth and safety.Ultrasonic percutaneous dosing technology starts from 1954, Fellinger and Schmid points polyarthritis through without tunica vasculose to treat for hydrocortisone first, obtains gradually since then and studies widely.The sixties in 20th century, the short technology of oozing of ultrasound wave starts extensive use sports medical science.To the eighties, the in vitro study about ultrasonic administration shows, ultrasonic energy strengthens the Transdermal absorption of a lot of medicine.
But adopt single means, such as: adopt merely electroporation, iontophoresis, thermotherapy, ultrasonicly have its limitation, cannot make medicine carry out fast and effectively through, adopt multiple means synergism, more can increase work efficiency than adopting single lead-in mode, strengthen the effect, particularly ultrasound wave of drugs delivery, can significantly strengthen percutaneous infiltration capacity.So, in the negative pressure space (administration space) at closed medicinal liquid place, create transdermal administration power--ultrasound wave high as far as possible, strengthen drug osmotic amount.
Summary of the invention
Technical problem to be solved by this invention is to provide the device of the ultrasonic percutaneous dosing of a kind of negative pressure of vacuum, and this device makes safety of medicine effectively through skin, fatty tissue and muscular tissue, to overcome the problem existing for the single lead-in mode of prior art.
The present invention for solving the problems of the technologies described above adopted technical scheme is: the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum, described transdermal delivery device is by the negative pressure device for producing vacuum suction to people's body surface with for making the capsule of bleeding producing negative pressure in negative pressure device form, bleed between capsule and negative pressure device and be fixedly connected with by screw thread, the bleed top of capsule is provided with bleed one-way cock and the air valve stationary pipes for one-way cock of fixedly bleeding, and is provided with the Vltrasonic device acting on human body in negative pressure device.
Negative pressure device of the present invention is also provided with an one-way cock with capsule junction of bleeding, and the shell of negative pressure device is also provided with injection one-way cock, and injection one-way cock is communicated with the conduit arranged in negative pressure device.
Vltrasonic device of the present invention is fixed by the supporting plate that arranges in negative pressure device and closed housing, Vltrasonic device is made up of ultrasonic probe and ultrasonic integrated package, the binding post that ultrasonic probe is arranged by its top is connected with ultrasonic integrated package with wire, and ultrasonic integrated package is connected with the voltage device that falls outside the circuit access port that negative pressure device shell is arranged and negative pressure device successively by wire.
The upper surface of ultrasonic probe of the present invention is provided with insulating cell, and lower surface is provided with protective layer.
Be provided with outside wire of the present invention for the protection of wire and the metallic channel ensureing safety.
Circuit access port (14) place of the present invention is also provided with a wire binding post.
The invention has the beneficial effects as follows: the present invention is the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum, has following beneficial effect: the first, uses easy to operate, and ingredient volatility is little, improve utilization ratio of drug, decrease drug waste; Second, the present invention utilizes negative pressure device to change the structure of skin surface, reduce the density of skin, improve permeability of cell membrane, expansion pore is beneficial to macromolecular drug and imports, make safety of medicine effectively through skin, fatty tissue and muscular tissue, to overcome the problem of the single lead-in mode of prior art; Three, apparatus of the present invention can make administration space tight, can make that skin surface is loose, Intradermal is congested through suction function, epidermal keratinocytes fault rupture, horn cell gap increase, skin resistance obviously reduces, meanwhile, for medicine provides the power of transdermal administration under hyperacoustic stimulation, with this improve medicine transdermal efficiency, increase the transdermal infiltration capacity of medicine, thus strengthen therapeutic effect; In addition; the present invention focuses on the detail setting of device very much; wire is stuck in metallic channel; wire can be made overall and not fragile, and connecting position of wires arranges binding post, because wiring place wire frangibility; binding post is arranged can guardwire; although ultrasonic probe and ultrasonic integrated package airtight by closed housing, in order to ensure safety, be provided with insulating cell and protective layer etc. respectively again on the top of ultrasonic probe and bottom.
Ultrasound wave has following superior effect:
1. the radiation pressure that hyperacoustic vibration at high speed produces makes medicine promote along the direction of sonic propagation, promotes drug osmotic;
2. the sound miniflow produced under hyperacoustic effect impels medicine to the channel flow of skin, sweat gland, hair follicle, and the shearforce that sound miniflow produces can also make the barrier of skin weaken, and increases the diffusibility of medicine;
3. hyperacoustic cavitation can cause the disordering of keratodermatitis double-layer of lipoid to arrange, and the horny layer space caused because of it may reach 4um, thus promotes the transdermal penetration of medicinal liquid.
To sum up, this device, by negative pressure of vacuum and hyperacoustic favourable combination, improves the transdermal efficiency of medicine, increases the transdermal infiltration capacity of medicine, thus strengthens therapeutic effect.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Fig. 2 is the structural representation of ultrasonic probe in the present invention;
Labelling in figure: 1, negative pressure device, 2, injection one-way cock, 3, conduit; 4, supporting plate, 5, capsule of bleeding, 6, one-way cock; 7, ultrasonic probe, 8, protective layer, 9, insulating cell; 10, ultrasonic integrated package, 11, binding post, 12, metallic channel; 13, closed housing, 14, circuit access port, 15, fall voltage device; 16, wire, 17, one-way cock of bleeding, 18, air valve stationary pipes.
Detailed description of the invention
As shown in Figure 1, the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum, described transdermal delivery device is by the negative pressure device 1 for producing vacuum suction to people's body surface with for making the capsule 5 of bleeding producing negative pressure in negative pressure device form, bleed between capsule 5 and negative pressure device 1 and be fixedly connected with by screw thread, the bleed top of capsule 5 is provided with bleed one-way cock 17 and the air valve stationary pipes 18 for one-way cock 17 of fixedly bleeding, and is provided with the Vltrasonic device acting on human body in negative pressure device 1.
Negative pressure device 1 is also provided with an one-way cock 6 with capsule 5 junction of bleeding, and the shell of negative pressure device 1 is also provided with injection one-way cock 2, and injection one-way cock 2 is communicated with the conduit 3 arranged in negative pressure device 1.
Vltrasonic device is fixed by the supporting plate 4 that arranges in negative pressure device 1 and closed housing 13, Vltrasonic device is made up of ultrasonic probe 7 and ultrasonic integrated package 10, the binding post 11 that ultrasonic probe 7 is arranged by its top is connected with ultrasonic integrated package 10 with wire 16, and ultrasonic integrated package 10 is connected with the voltage device 15 that falls outside the circuit access port 14 that negative pressure device 1 shell is arranged and negative pressure device 1 successively by wire 16.
The upper surface of ultrasonic probe 7 is provided with insulating cell 9, and lower surface is provided with protective layer 8.
Be provided with outside wire 16 for the protection of wire and the metallic channel 12 ensureing safety.
Circuit access port 14 place is also provided with a wire binding post.
Apparatus of the present invention in use, pass through injection one-way cock 2 to liquid medicine injection in negative pressure device 1 with syringe, and then extrude with hands capsule 5 of bleeding and make device reach negative pressure state, switch on power line, device is operated and promotes the absorption of medicinal liquid.The medicinal liquid syringe of finishing using unnecessary is drawn back by injection one-way cock 2.
Claims (6)
1. the ultrasonic transdermal delivery device of negative pressure of vacuum, it is characterized in that: described transdermal delivery device is by the negative pressure device (1) for producing vacuum suction to people's body surface with for making the capsule of bleeding (5) producing negative pressure in negative pressure device form, bleed between capsule (5) and negative pressure device (1) and be fixedly connected with by screw thread, the bleed top of capsule (5) is provided with one-way cock of bleeding (17) and the air valve stationary pipes (18) for one-way cock of fixedly bleeding (17), in negative pressure device (1), be provided with the Vltrasonic device acting on human body.
2. the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum according to claim 1, it is characterized in that: described negative pressure device (1) is also provided with an one-way cock (6) with capsule (5) junction of bleeding, the shell of negative pressure device (1) is also provided with injection one-way cock (2), injection one-way cock (2) is communicated with the conduit (3) arranged in negative pressure device (1).
3. the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum according to claim 1, it is characterized in that: described Vltrasonic device by the supporting plate (4) that arranges in negative pressure device (1) and closed housing (13) fixing, Vltrasonic device is made up of ultrasonic probe (7) and ultrasonic integrated package (10), the binding post (11) that ultrasonic probe (7) is arranged by its top is connected with ultrasonic integrated package (10) with wire (16), ultrasonic integrated package (10) is connected with the circuit access port (14) that negative pressure device (1) shell is arranged and negative pressure device (1) voltage device (15) that falls outward successively by wire (16).
4. the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum according to claim 3, is characterized in that: the upper surface of described ultrasonic probe (7) is provided with insulating cell (9), and lower surface is provided with protective layer (8).
5. the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum according to claim 3, is characterized in that: described wire (16) outside is provided with for the protection of wire and the metallic channel (12) ensureing safety.
6. the ultrasonic transdermal delivery device of a kind of negative pressure of vacuum according to claim 3, is characterized in that: described circuit access port (14) place is also provided with a wire binding post.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510115751.2A CN104689465A (en) | 2015-03-17 | 2015-03-17 | Vacuum negative pressure ultrasonic transdermal drug delivery device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510115751.2A CN104689465A (en) | 2015-03-17 | 2015-03-17 | Vacuum negative pressure ultrasonic transdermal drug delivery device |
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| CN104689465A true CN104689465A (en) | 2015-06-10 |
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| CN201510115751.2A Pending CN104689465A (en) | 2015-03-17 | 2015-03-17 | Vacuum negative pressure ultrasonic transdermal drug delivery device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106730078A (en) * | 2017-01-06 | 2017-05-31 | 山东酵元生物科技有限公司 | A kind of built-in ultrasonic wave cup |
| CN109498980A (en) * | 2018-12-29 | 2019-03-22 | 重庆太极实业（集团）股份有限公司 | A kind of ageratum-liquid negative pressure administration product and its application |
| CN110193138A (en) * | 2019-06-14 | 2019-09-03 | 翁作森 | Drug penetration through skin device |
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| US20040039343A1 (en) * | 2000-06-08 | 2004-02-26 | Jonathan Eppstein | Transdermal drug delivery device, method of making same and method of using same |
| CN2621063Y (en) * | 2003-04-21 | 2004-06-23 | 赵宽 | Negative-pressure ultrasonic osmotic-promoting administration apparatus |
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| CN102068755A (en) * | 2010-11-11 | 2011-05-25 | 王建友 | Therapy device for percutaneously introducing Chinese herbal medicine into human body |
| US20110144564A1 (en) * | 2001-08-21 | 2011-06-16 | Hennings David R | Enhanced noninvasive collagen remodeling |
| CN202409613U (en) * | 2011-12-27 | 2012-09-05 | 广州市康乃馨健康发展有限公司 | Multifunctional pulse physiotherapy cosmetic instrument |
| CN202566821U (en) * | 2012-03-06 | 2012-12-05 | 青岛唯美德科美容科技股份有限公司 | Negative pressure water supplementing instrument for supplementing water to face |
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2015
- 2015-03-17 CN CN201510115751.2A patent/CN104689465A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040039343A1 (en) * | 2000-06-08 | 2004-02-26 | Jonathan Eppstein | Transdermal drug delivery device, method of making same and method of using same |
| US20110144564A1 (en) * | 2001-08-21 | 2011-06-16 | Hennings David R | Enhanced noninvasive collagen remodeling |
| CN2621063Y (en) * | 2003-04-21 | 2004-06-23 | 赵宽 | Negative-pressure ultrasonic osmotic-promoting administration apparatus |
| CN201791250U (en) * | 2010-09-27 | 2011-04-13 | 马月兰 | Negative pressure type coupling agent applicator |
| CN102068755A (en) * | 2010-11-11 | 2011-05-25 | 王建友 | Therapy device for percutaneously introducing Chinese herbal medicine into human body |
| CN202409613U (en) * | 2011-12-27 | 2012-09-05 | 广州市康乃馨健康发展有限公司 | Multifunctional pulse physiotherapy cosmetic instrument |
| CN202566821U (en) * | 2012-03-06 | 2012-12-05 | 青岛唯美德科美容科技股份有限公司 | Negative pressure water supplementing instrument for supplementing water to face |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106730078A (en) * | 2017-01-06 | 2017-05-31 | 山东酵元生物科技有限公司 | A kind of built-in ultrasonic wave cup |
| CN109498980A (en) * | 2018-12-29 | 2019-03-22 | 重庆太极实业（集团）股份有限公司 | A kind of ageratum-liquid negative pressure administration product and its application |
| CN110193138A (en) * | 2019-06-14 | 2019-09-03 | 翁作森 | Drug penetration through skin device |
| CN110193138B (en) * | 2019-06-14 | 2023-12-26 | 湖南铭仁控股集团有限公司 | Drug skin permeation device |
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Application publication date: 20150610 |
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