CN104689067A - Traditional Chinese medicine composition for treating sexual precocity and application thereof - Google Patents

Abstract

A traditional Chinese medicine composition for treating sexual precocity comprises the following raw materials: oriental wormwood, monkshood, semen cuscutae, poria cocos, radix ophiopogonis, tangerine peel, rhizoma pinelliae preparata, fructus aurantii, periostracum cicadae, gorgon fruit, ginkgo seeds, radix rehmanniae preparata, angelica sinensis, radix asparagi, gentian, fructus lycii, cistanche salsa, rhizoma chuanxiong, hawthorns, paeonia suffruticosa, fried gardenia, snakegourd peel, calcined oyster, rhizoma alismatis, glossy privet fruit, cortex lycii radicis, purslane, root of kudzu vine, balsam pears, radix glycyrrhizae, salviae miltiorrhizae, spiranthes sinensis, caltrop, herba ecliptae and polygonum multiflorum. The traditional Chinese medicine composition has high efficiency and no side effect, and is low in cost and suitable for treating various types of child sexual precocity.

Description

A kind of Chinese medicine composition for the treatment of precocious puberty and application thereof

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition and application thereof for the treatment of precocious puberty.

Background technology

So-called sexual precosity refers to that girl occurred breast development before 8 years old, and cloudy, armpit hair grows and menarche then, and the increase of testis, penis, the growth of cloudy armpit hair, erection, even ejaculation phenomenon appearred in boy before 9 years old.According to relevant investigation, from 80 years, Chinese children sexual precosity was cumulative year after year trend.

Children's sexual precocity can be divided into clinically:

1, true precocious puberty: be caused by hypothalamic pituitary gonadal axis starts in advance, its genesis mechanism is identical with normal condition, endocrine change is all similar with normal mature with inside and outside phallic growth, with height and weight accelerated growth, skeleton is in advance closed, growth is early stage to be stopped, and causes final height shorter.True precocious puberty, also known as Central precocious puberty, except referring to the secondary sex characteristics that patient is consistent with sex except performance, has Acceleration of growth, stone age increase simultaneously and has reproductive performance.

2, pseudo-precocious puberty: be have abnormal too much gonadal hormone source to cause due to external, body intrinsic factor is many caused by peripheral endocrine gland (gonad or adrenal cortex) pathological changes; Extrinsic factor mostly is medicine and food, the nutriment that misuse contains gonadal hormone, and use the cosmetics containing gonadal hormone, mother's pregnancy period or age of sucking take the medicine etc. containing sex gland hormones.

3, sexual precocity,incomplete: this precocity, not by the control of hypothalamic pituitary gonadal axis, only has breast or pubes to grow, and without other features.

In above-mentioned three kinds of pubertas praecoxs, because the cause of disease is different, Therapeutic Method is also different.As found tumor, answer excision; As should be stopped the absorption containing sex hormone drug and food immediately for extrinsic factor; If can not find the idiopathic sexual precocity of reason, mostly adopt doctor trained in Western medicine clinical treatment both at home and abroad at present.In recent years, children's sexual precocity sickness rate improves constantly.Wherein, what need to carry out Drug therapy is central idiopathic sexual precocity, and ratio is quite high.Trace it to its cause except with heredity and outside the Pass physical factors has, mostly and alteration in nutrition, environmental pollution and social factor have comparatively Important Relations.True precocious puberty infant starts ahead of time due to hypothalamic pituitary gonadal axis, and cause sex character to occur too early, bone growth accelerates, and if do not added intervention, quite a few infant closes too early because of bone marrow, causes its final height lower than same age normal development child; Meanwhile, because of relatively lagging behind of infant psychosexual development, easily cause learning and all difficulties in life.、

At present, the most effective internationally recognized medicine is that gonadotropin releasing hormone is intended like agent (GnRHa), megestrol.But GnRHa is expensive, though megestrol can make sex character disappear, skeletal maturation is accelerated without obvious therapeutic action, and easily causes obesity; There is report life-time service that the incidence rate of infant polycystic ovarian syndrome can be made to increase abroad.

Recent two decades comes, and Chinese medicine sexual precosity effectively can improve sings and symptoms, and without obvious toxicity, therefore widely use clinical.The traditional Chinese medical science is main relevant with hyperactivity of fire caused by deficiency of YIN, pathogenic fire derived from stagnation of liver-QI and phlegm-damp cohesion etc. to the pathogenetic understanding of children's sexual precocity.For above-mentioned pathogenic characteristic, current traditional Chinese medical science bound pair CPP Therapeutic Method based on nourishing YIN to lower pathogenic fire and soothing the liver pathogenic fire purging method, or combines employing dissipating phlegm and resolving masses method.But lack the Chinese medicine preparation of the children's sexual precocity of the various pattern of syndrome of effective percentage treatment that is high, that have no side effect clinically.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of precocious puberty, to solve the poor problem of curative effect that existing Chinese medicine exhausts sexual precosity.Chinese medicine composition effective percentage of the present invention is high, and without side reaction, cost is low, is applicable to the treatment of the treatment children's sexual precocity of various disease type.

Above-mentioned purpose of the present invention is realized by following technical proposals:

A Chinese medicine composition for treating precocious puberty, the crude drug of described Chinese medicine composition is made up of Herba Artemisiae Scopariae, Radix Aconiti Lateralis Preparata, Semen Cuscutae, Poria, Radix Ophiopogonis, Pericarpium Citri Reticulatae, Rhizoma Pinelliae, Fructus Aurantii, Periostracum Cicadae, Semen Euryales, Semen Ginkgo, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Asparagi, Radix Gentianae, Fructus Lycii, Herba Cistanches, Rhizoma Chuanxiong, Fructus Crataegi, Cortex Moutan, Fructus Gardeniae (parched), Pericarpium Trichosanthis, Concha Ostreae (calcined), Rhizoma Alismatis, Fructus Ligustri Lucidi, Cortex Lycii, Herba Portulacae, Radix Puerariae, Fructus Momordicae charantiae, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix seu Herba Spiranthis Lanceae, Fructus Tribuli, Herba Ecliptae, Radix Polygoni Multiflori.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 12-20 part, Radix Aconiti Lateralis Preparata 10-16 part, Semen Cuscutae 3-8 part, Radix Ophiopogonis 5-12 part, Pericarpium Citri Reticulatae 12-17 part, Rhizoma Pinelliae 4-9 part, Radix Angelicae Sinensis 15-20 part, Fructus Momordicae charantiae 10-15 part, Poria 8-12 part, Fructus Aurantii 2-5 part, Radix Glycyrrhizae 3-7 part, Periostracum Cicadae 11-14 part, Semen Euryales 9-15 part, Semen Ginkgo 3-6 part, Radix Rehmanniae Preparata 8-13 part, Cortex Lycii 3-5 part, Radix Asparagi 1-3 part, Radix Gentianae 5-10 part, Herba Portulacae 5-10 part, Fructus Lycii 13-16 part, Herba Cistanches 3-10 part, Rhizoma Chuanxiong 7-11 part, Radix Puerariae 7-12 part, Fructus Crataegi 2-4 part, Cortex Moutan 6-8 part, Fructus Gardeniae (parched) 20-30 part, Pericarpium Trichosanthis 16-25 part, Concha Ostreae (calcined) 4-7 part, Rhizoma Alismatis 12-18 part, Fructus Ligustri Lucidi 5-12 part, Radix Salviae Miltiorrhizae 3-5 part, Radix seu Herba Spiranthis Lanceae 13-20 part, Fructus Tribuli 16-30 part, Herba Ecliptae 13-16 part, Radix Polygoni Multiflori 3-10 part.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 12 parts, Radix Aconiti Lateralis Preparata 16 parts, Semen Cuscutae 3 parts, Radix Ophiopogonis 12 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Pinelliae 9 parts, Radix Angelicae Sinensis 15 parts, 15 parts, Fructus Momordicae charantiae, 8 parts, Poria, Fructus Aurantii 5 parts, 3 parts, Radix Glycyrrhizae, Periostracum Cicadae 14 parts, Semen Euryales 9 parts, Semen Ginkgo 6 parts, 8 parts, Radix Rehmanniae Preparata, Cortex Lycii 5 parts, Radix Asparagi 1 part, Radix Gentianae 10 parts, Herba Portulacae 5 parts, Fructus Lycii 16 parts, Herba Cistanches 3 parts, Rhizoma Chuanxiong 11 parts, Radix Puerariae 10 parts, Fructus Crataegi 2 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 25 parts, Pericarpium Trichosanthis 20 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 16 parts, Fructus Ligustri Lucidi 10 parts, Radix Salviae Miltiorrhizae 4 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Fructus Tribuli 28 parts, Herba Ecliptae 13 parts, Radix Polygoni Multiflori 10 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 20 parts, Radix Aconiti Lateralis Preparata 10 parts, Semen Cuscutae 8 parts, Radix Ophiopogonis 5 parts, Pericarpium Citri Reticulatae 17 parts, Rhizoma Pinelliae 4 parts, Radix Angelicae Sinensis 20 parts, 10 parts, Fructus Momordicae charantiae, 12 parts, Poria, Fructus Aurantii 2 parts, 7 parts, Radix Glycyrrhizae, Periostracum Cicadae 11 parts, Semen Euryales 15 parts, Semen Ginkgo 3 parts, 13 parts, Radix Rehmanniae Preparata, Cortex Lycii 3 parts, Radix Asparagi 3 parts, Radix Gentianae 5 parts, Herba Portulacae 10 parts, Fructus Lycii 13 parts, Herba Cistanches 10 parts, Rhizoma Chuanxiong 7 parts, Radix Puerariae 12 parts, Fructus Crataegi 4 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 20 parts, Pericarpium Trichosanthis 18 parts, Concha Ostreae (calcined) 5 parts, Rhizoma Alismatis 12 parts, Fructus Ligustri Lucidi 5 parts, Radix Salviae Miltiorrhizae 3.5 parts, Radix seu Herba Spiranthis Lanceae 16 parts, Fructus Tribuli 30 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 5 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 13 parts, Radix Aconiti Lateralis Preparata 11 parts, Semen Cuscutae 4 parts, Radix Ophiopogonis 6 parts, Pericarpium Citri Reticulatae 13 parts, Rhizoma Pinelliae 5 parts, Radix Angelicae Sinensis 18 parts, 11 parts, Fructus Momordicae charantiae, 9 parts, Poria, Fructus Aurantii 4 parts, 6 parts, Radix Glycyrrhizae, Periostracum Cicadae 12 parts, Semen Euryales 13 parts, Semen Ginkgo 4 parts, 9 parts, Radix Rehmanniae Preparata, Cortex Lycii 4 parts, Radix Asparagi 2 parts, Radix Gentianae 6 parts, Herba Portulacae 6 parts, Fructus Lycii 14 parts, Herba Cistanches 5 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 7 parts, Fructus Crataegi 3 parts, Cortex Moutan 6 parts, Fructus Gardeniae (parched) 20 parts, Pericarpium Trichosanthis 16 parts, Concha Ostreae (calcined) 7 parts, Rhizoma Alismatis 18 parts, Fructus Ligustri Lucidi 6 parts, Radix Salviae Miltiorrhizae 3 parts, Radix seu Herba Spiranthis Lanceae 18 parts, Fructus Tribuli 18 parts, Herba Ecliptae 16 parts, Radix Polygoni Multiflori 3 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 17 parts, Radix Aconiti Lateralis Preparata 15 parts, Semen Cuscutae 7 parts, Radix Ophiopogonis 11 parts, Pericarpium Citri Reticulatae 16 parts, Rhizoma Pinelliae 8 parts, Radix Angelicae Sinensis 16 parts, 14 parts, Fructus Momordicae charantiae, 11 parts, Poria, Fructus Aurantii 3 parts, 5 parts, Radix Glycyrrhizae, Periostracum Cicadae 13 parts, Semen Euryales 14 parts, Semen Ginkgo 5 parts, 12 parts, Radix Rehmanniae Preparata, Cortex Lycii 3 parts, Radix Asparagi 1 part, Radix Gentianae 10 parts, Herba Portulacae 9 parts, Fructus Lycii 13 parts, Herba Cistanches 7 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 8 parts, Fructus Crataegi 2 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 30 parts, Pericarpium Trichosanthis 25 parts, Concha Ostreae (calcined) 6 parts, Rhizoma Alismatis 13 parts, Fructus Ligustri Lucidi 12 parts, Radix Salviae Miltiorrhizae 5 parts, Radix seu Herba Spiranthis Lanceae 13 parts, Fructus Tribuli 23 parts, Herba Ecliptae 15 parts, Radix Polygoni Multiflori 8 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 15 parts, Radix Aconiti Lateralis Preparata 12 parts, Semen Cuscutae 5 parts, Radix Ophiopogonis 9 parts, Pericarpium Citri Reticulatae 15 parts, Rhizoma Pinelliae 7 parts, Radix Angelicae Sinensis 19 parts, 13 parts, Fructus Momordicae charantiae, 10 parts, Poria, Fructus Aurantii 4 parts, 4 parts, Radix Glycyrrhizae, Periostracum Cicadae 11 parts, Semen Euryales 11 parts, Semen Ginkgo 5 parts, 10 parts, Radix Rehmanniae Preparata, Cortex Lycii 5 parts, Radix Asparagi 3 parts, Radix Gentianae 58 parts, Herba Portulacae 8 parts, Fructus Lycii 14 parts, Herba Cistanches 6 parts, Rhizoma Chuanxiong 9 parts, Radix Puerariae 9 parts, Fructus Crataegi 4 parts, Cortex Moutan 7 parts, Fructus Gardeniae (parched) 28 parts, Pericarpium Trichosanthis 22 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 15 parts, Fructus Ligustri Lucidi 5 parts, Radix Salviae Miltiorrhizae 3 parts, Radix seu Herba Spiranthis Lanceae 14 parts, Fructus Tribuli 16 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 7 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 19 parts, Radix Aconiti Lateralis Preparata 14 parts, Semen Cuscutae 6 parts, Radix Ophiopogonis 7 parts, Pericarpium Citri Reticulatae 14 parts, Rhizoma Pinelliae 6 parts, Radix Angelicae Sinensis 17 parts, 12 parts, Fructus Momordicae charantiae, 9 parts, Poria, Fructus Aurantii 4 parts, 4 parts, Radix Glycyrrhizae, Periostracum Cicadae 12 parts, Semen Euryales 10 parts, Semen Ginkgo 4 parts, 11 parts, Radix Rehmanniae Preparata, Cortex Lycii 4 parts, Radix Asparagi 1 part, Radix Gentianae 7 parts, Herba Portulacae 7 parts, Fructus Lycii 15 parts, Herba Cistanches 8 parts, Rhizoma Chuanxiong 8 parts, Radix Puerariae 11 parts, Fructus Crataegi 4 parts, Cortex Moutan 6 parts, Fructus Gardeniae (parched) 26 parts, Pericarpium Trichosanthis 20 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 16 parts, Fructus Ligustri Lucidi 10 parts, Radix Salviae Miltiorrhizae 4 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Fructus Tribuli 28 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 9 parts.

Further, described Chinese medicine composition makes mixture, tablet, oral liquid, capsule or granule, and wherein said mixture, tablet, oral liquid, capsule, granule are prepared by the following method:

The preparation method of described mixture is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, add the water of 8 times of medical material gross weight, soak after 30-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the water of 10 times of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the water of 12 times of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, filtrate reduced in volume is to the extractum of relative density 1.1-1.15, this relative density is testing result at 60 c, adding ethanol to alcohol content is 75% (v/v), leave standstill 3040 hours, get supernatant, decompression recycling ethanol concentrates, add water to 1000ml, stir evenly, subpackage, flowing steam sterilization 35min, obtain mixture,

The preparation method of described tablet is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, with 50% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adding ethanol to alcohol content is 85% (v/v), leave standstill 24 hours, get supernatant, decompression recycling ethanol is to concentrated, vacuum drying, granulation, tabletting and get final product;

The preparation method of described capsule is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, add the water of 10 times of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the water of 12 times of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the water of 14 times of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, filtrate reduced in volume is to the extractum of relative density 1.2-1.25, this relative density is testing result at 60 c, adding ethanol to alcohol content is 90% (v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulate, encapsulated and get final product,

The preparation method of described granule is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, adds 8 times of water gagings, decocts 3 hours, leaches medicine juice; Add 6 times of water gagings again, decoct 2 hours, leach medicine juice; Merge secondary decocting liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, make alcohol content be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule;

The preparation method of described oral liquid is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, adds 9 times of water gagings, decocts 2 hours, leaches medicine juice; Add 10 times of water gagings again, decoct 3 hours, leach medicine juice; Merge secondary decocting liquid, when filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.15, adds ethanol, makes alcohol content be 50%, leave standstill 24 hours, filter, filtrate is concentrated into 2 times of medical material gross weight, adds adjuvant Mel, monoglycosides, benzoic acid, after stirring evenly fine straining, subpackage, sterilizing, obtained oral liquid.

The invention still further relates to a kind of application of Chinese medicine composition in treating precocious puberty medicine for the treatment of precocious puberty.

The Chinese medicine composition for the treatment of precocious puberty provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis." herbal classic ": the raw pathogenic heat gas of main air, accumulation of heat jaundice." not Lu ": control the whole body jaundice, dysuria, except feverish sensation in the head, removes mass in the large intestine.Supplement to the Herbal: get round by bribery, go stagnant heat, typhoid fever uses it." medical center bun is wanted ": hard kidney, dry spleen wets, and goes strongly fragrant, antipyretic." book on Chinese herbal medicine is new again ": pathogenic fire purging, suppressing the hyperactive liver, reduces phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treats all poison of skin ulcer fire.

Radix Aconiti Lateralis Preparata: pungent, sweet is warm greatly; Poisonous.GUIXIN, kidney, spleen channel.Function recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes." herbal classic ": main air is trembled with fear cough with dyspnea pathogen, warming middle-JIAO, and incised wound ， Po Disorder heavily fortified point gathers, abdominal mass due to blood stasis, Han Shi Wei lame, contracture gonalgia, can not go step.Essentials of Matea Medica: the kidney invigorating life fire, wets by wind and cold." book on Chinese herbal medicine converges and says ": Radix Aconiti Lateralis Preparata, recuperating depleted YANG gas, loose YIN-cold, by cold phlegm, the violent medicine of getting round by bribery also.All sick insufficiency of kidney-YANG, depletion fire syndrome going up, discomfort in the throat, anorexia, more notably, Radix Aconiti Lateralis Preparata is gate of vitality's principal agent to the cold medicine of clothes, can enter Qi Ku cave and recruit it, conducting fire back to its origin, then the fire swum is from putting out.

Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia." herbal classic ": the inverse gas of the main breast side of body, melancholy is angerd frightened heresy and is probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, the burnt dry tongue of mouth, diuresis." not Lu ": only quench one's thirst, like to sleep, large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema drenches knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." property of medicine opinion ": appetizing, preventing or arresting vomiting is inverse, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria." Japan hanako materia medica ": mend five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, happy Fructus Alpiniae Oxyphyllae, only forgetful.

Radix Ophiopogonis: sweet micro-hardship, cold.Enter lung, stomach, heart channel.Function cures mainly: nourishing YIN and moistening the lung, and clear away heart-fire relieving restlessness, reinforcing stomach reg fluid.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quenches one's thirst, and calentura Tianjin is hindered, dry mouth and throat, constipation." herbal classic ": main stagnation of QI in chest and abdomen, damaging the spleen and stomach wound is full, and stomach channels is exhausted, and weakness and emaciation is losed heart." Japan hanako materia medica ": control five kinds of strain and seven kinds of impairment, peace soul determine soul, time disease fanatical, have a headache, antitussive.Amplification on Canon of Materia Medica: control cardiopulmonary deficiency-heat." pearl sac ": control the lung fire second of the three ten-day periods of the hot season, raw arteries and veins protects god.

Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Temperature can circulation of qi promoting, pungently can disperse, bitter and sluice.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.

Rhizoma Pinelliae: acrid in the mouth, warm in nature; Poisonous.Return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI." herbal classic ": main typhoid fever cold and heat, hardness in the epigastrium, the therapeutic method to keep the adverse QI flowing downwards, laryngopharynx swells and ache, and dizziness breast is swollen, cough with dyspnea, borborygmus, hidroschesis." not Lu ": the full knot of diabetes with polydipsia as the prominent symptom abdomen chest and diaphragm expectorant heat, cough with dyspnea, the hard painful abdominal mass of acute pain in the epigastrium, seasonal epidemic pathogens vomiting; Subduing inflammation, induced abortion, treats dull yellowish colored skin, happy damp appearance.Raw make us telling, ripely to make us down." property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.

Fructus Aurantii: bitter in the mouth, pungent, sour, warm in nature.Return spleen, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus." property of medicine opinion ": control rubella all over, dislikes as numb bean in flesh and itches, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen, and the swollen void of two sides of body, pass diaphragm is congested." Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed." pearl sac ": dispelling the stagnated QI, lets out gas unfavorable in lung." medicine origin ": " curing mainly secret formula " cloud, broken hardness in the epigastrium painful abdominal mass, profit is gas in the heart, reduces phlegm, and helps digestion.

Periostracum Cicadae: sweet in the mouth, cold in nature.Return lung, Liver Channel.Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus." not Lu ": main children's's epilepsy; The main chronic dysentery of ash clothes." property of medicine opinion ": control children's's high fever infantile convulsion from head to foot, doublely can quench the thirst." detailed outline ": control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva.

Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Function cures mainly: supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.For emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia." herbal classic ": main arthralgia chiefly caused by damp pathogen spinal column gonalgia, invigorating middle warmer is except sudden and violent disease, and beneficial vital essence, Qiang Zhi, makes normal hearing and eyesight." Japan hanako materia medica ": appetizing helps gas." detailed outline ": quench the thirst kidney tonifying.Control incontinence of urine, seminal emission, nebulousurine, leukorrhagia." Bencao Congxin ": spleen reinforcing is reinforced the kidney, helps gas arresting seminal emission.Control emission, separate summer-heat alcoholism, treat foul leukorrhea and have loose bowels, incontinence of urine." book on Chinese herbal medicine newly organized " cloud: " Semen Euryales, also, its merit is entirely in the kidney invigorating damp eliminating ... Semen Euryales invigorating middle warmer is dried, and property is not dry again for assistant envoy, therefore the water and mend true water, use same with all YIN-tonifying drug of uncharming, especially can help to add essence, do not consider throw and humidification more yet ".

Semen Ginkgo: sweet in the mouth, hardship, puckery, property is put down; Poisonous.Return lung meridian.Function cures mainly: astringing lung QI for relieving asthma, and leukorrhagia stopping is turbid, urine reducing.Breath with cough for abundant expectoration, leukorrhagia nebulousurine, enuresis frequent micturition." Elementary Medicine ": lung heat clearing stomach foul smell, eliminating phlegm to relieve asthma, cough-relieving." detailed outline ": prepared food warming the lung and benefiting QI, relieving asthma and cough, urine reducing, only nebulousurine; Eat raw and fall expectorant, disinfection; (smashing) is coated with nasal surface brothers, and go Zha to steep, Shao-is dim, and chapped wrinkle and scabies infantile malnutrition are hidden, pubic louse." book on Chinese herbal medicine is new again ": QI invigorating nourishes heart, kidney tonifying YIN nourishing, cough-relieving relieving restlessness, granulation promoting is put on flesh, and evacuation of pus is drawn out pus by applying a plaster to the affected part, the skin ulcer that disappears scabies cellulitis tumor." book on Chinese herbal medicine is just read ": gold of above astringing the lung is except cough with dyspnea, and descending turbid damp reduces phlegm saliva." Shandong Chinese medicine ": control seminal emission, the enuresis.

Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair." pearl sac ": enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting." detailed outline ": fill out bone marrow, longue meat, promoting generation of vital essence and blood, tonifying five ZANG-organs, internal injury are not enough, and promoting blood circulation, Li Er, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments." Bencao Congxin ": kidney nourishing water, packing bone marrow, sharp blood vessels, tonification is Kidney-Yin, hearing-improing and eyesight improving, hair color crow palpus.Again can tonifying spleen-yin, only chronic diarrhea, controls impairment caused by overstrain migratory arthralgia, cloudyly loses heating, dry cough phlegmatic cough, dyspnea with shortness of breath, emptiness of the stomach feels hungry, and pox demonstrate,proves no pus of having a guilty conscience, and shin stock is ached after being ill, the anxious pain of umbilicus abdomen in puerperal, and sense card the moon loses, losslessly just close, all kinds of dynamic blood, all hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments are strengthening renal yin to inhibit predominant yang medicine." book on Chinese herbal medicine is just ": Radix Rehmanniae Preparata is put down, and abnormal smells from the patient is pure quiet, therefore energy tonifying five ZANG-organs is Kidney-Yin.

Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down." herbal classic ": main cough with dyspnea, pyrexial malaria cold and heat are washed in skin, and married woman is leaked down, sterilization, all malignant boil infections incised wounds, boil drink." property of medicine opinion ": preventing or arresting vomiting is inverse, asthenia cold and heat, broken stagnated blood, main woman's metrorrhagia, lower the intestines and stomach is cold, mends various symptoms and signs of deficiency, and dysentery relieving is suffered from abdominal pain.Singly boil drink juice, control pyrexial malaria, main woman's lumbago with blood stasis, treat tooth pain unbearably painful.Suffer from people's cold caused by deficiency add and use it." book on Chinese herbal medicine is new again ": control swelling from head to foot, blood vessels are got along well, and cloudy point not enough, peaceful tire, stillborn fetus of falling.

Radix Asparagi: sweet in the mouth, hardship, cold in nature.Return lung, kidney channel.Function cures mainly: nourishing YIN to relieve dryness, and lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.

Radix Gentianae, bitter, cold.Return liver, gallbladder meridian.Be used as medicine part for gentianaceae plant Radix Gentianae, Gentiana manshurica, G. triflora and Yunnan Radix Gentianae, root welding technology.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms." detailed outline ": treat throat pain, wind heat night sweat.Fire is posted in liver and gall mutually, have rush down of no help, therefore the gas of the liver benefiting gallbladder of Radix Gentianae, just with its can eliminating pathogen in the liver gallbladder pathogenic heat also.But in large bitter Great Cold, cross clothes and probably to injure one's stomach the gas of middle hair growth promoting, instead help pathogenic fire, also take Rhizoma Coptidis for a long time instead from the justice of cremate." book on Chinese herbal medicine is newly organized ": Radix Gentianae, its merit, specially in diuretic, disappears wet, and except jaundice, all the other are controlled order, dysentery relieving, detumescent, bring down a fever, and the speech of all popularizations also.But this kind too divides profit, rather consume gas deteriorated blood, water goes and blood also goes, wet disappearing and gas also disappears, from the beginning of water to wet jaundice, have to urgently with it, the water of prolonged illness wets jaundice, with must delay, just cannot not entirely rely on for diuretic god red, disappearing the wet miraculous cure removing illness also.Or meaning Radix Gentianae is controlled damp and hot, the most sharp illness is sick, just damp and hot disease also, so with Radix Gentianae with subcutaneous ulcer of harnessing the Yellow River, have not effect person, how also more? the real incessantly damp and hot one of jaundice also, have not hot and also become jaundice person, can control also by non-Radix Gentianae.Outstanding Radix Gentianae rushes down the heat in wetting, and can not rush down not hot wetting also.

Fructus Lycii, sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, beneficial intensive culture blood, improving eyesight removing nebula, nourishing the lung to arrest cough.Cure mainly the atrophic debility of bones of suffering from a deficiency of the kidney, impotence and seminal emission, fertility of a specified duration, senilism senilism, early whitening of beard and hair, blood deficiency and yellow complexion, the diseases such as puerperal, breast was few, poor vision, interior external oculopathy eye, and interior-heat is quenched one's thirst, consumptive fever hectic fever due to YIN-deficiency, and chronic consumptive disease is coughed, the few expectorant of dry cough.

Herba Cistanches, sweet, salty, temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation." herbal classic ": " main five kinds of strain and seven kinds of impairment, invigorating middle warmer, except stem invasion by pathogenic cold burning pain, support the five internal organs, reinforcing YIN-essence, beneficial vital essence, gynecological mass in abdomen.”

Rhizoma Chuanxiong, nature and flavor are pungent, temperature.Enter liver, gallbladder meridian.Cure mainly activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Fructus Crataegi, sour, sweet, tepor.Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.

Cortex Moutan, bitter, pungent, be slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.

Fructus Gardeniae (parched) is bitter, cold.GUIXIN, lung, tri-jiao channel.Cure mainly pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

Pericarpium Trichosanthis is the dry mature skin of cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms Trichosanthesrosthomii Harms.Sweet, cold.Attach to the lung and stomach meridians.Qinghua heat-phlegm, promoting the circulation of QI the chest stuffiness relieving.For phlegm-heat cough, hypochondriac pain uncomfortable in chest.

Concha Ostreae (calcined), salty, be slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Rhizoma Alismatis, sweet, cold.Return kidney, urinary bladder channel.Diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.

Fructus Ligustri Lucidi, sweet, bitter, cold.Return liver, kidney channel.Invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision." book on Chinese herbal medicine just ": " yin nourishing gas, Pingyin fire, separates dysphoria with smothery sensation hectic fever due to YIN-deficiency, and only sweating due to debility, quenches one's thirst, and stranguria with turbid discharge, and metrorrhagia, has blood in stool, hematuria, the erosion of vulva, anal fistula pain.Also clearing away liver-fire, can improving eyesight arresting lacrimation.”

Cortex Lycii: cold in nature, sweet in the mouth, returns liver, kidney, lung meridian, mainly has the effects such as blood sugar lowering, antimicrobial, antipyretic, blood pressure lowering, blood fat reducing, immunomodulating.

Herba Portulacae, acid, cold.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea; Furuncle swelling toxin is controlled in external, eczema, herpes zoster.Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.”

Radix Puerariae: Gan Xin is flat.Enter spleen, stomach warp.Yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is quenched the thirst, and cures the wound cold, and warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst.

Fructus Momordicae charantiae: abnormal smells from the patient is bitter, nontoxic, cold in nature, enter the heart, liver, spleen, lung meridian, have clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separate that labor clears away heart-fire, effect of QI invigorating tonifying YANG, find according to the study, it also has good blood sugar lowering, antiviral and anti-cancer efficacy.

Semen Cuscutae is the dry mature seed of convolvulaceous plant Cuscuta australis CuscutaaustralisR.Br. or Semen Cuscutae CuscutachinensisLam..Pungent, sweet, flat.Return liver,kidney,spleen warp.Can liver and kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal; External pathogenic wind expelling speckle dispelling.For deficiency of the liver and kindey, soreness of the waist and knees, impotence and seminal emission, enuresis frequent micturition.Vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, blurred vision tinnitus, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.

Radix Glycyrrhizae: sweet in the mouth is put down, GUIXIN, lung, taste warp, invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing; Modern pharmacological research Radix Glycyrrhizae has the effect of adrenocortical hormone sample, cellular immunization and humoral immunization can be strengthened, suppress humoral immunization and the immunologic function such as antiallergic, antiallergic action dual regulation, there is the antiinflammatory action of hydrocortisone sample, broad-spectrum antiviral, antibacterial, antiulcer, spasmolytic, antitumor action, blood fat reducing, anti-atherosclerosis, removing toxic substances.

Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltionhiza Bunge..Hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Radix seu Herba Spiranthis Lanceae, sweet, bitter, flat, GUIXIN, lung meridian, supplementing QI and nourishing YIN; Heat-clearing and toxic substances removing.Main weak after being ill; Yin asthenia generating intrinsic heat; Cough is spitted blood; Dizzy; Lumbago is aching and limp; Diabetes; Seminal emission; Stranguria with turbid discharge leukorrhagia; Laryngopharynx swelling and pain; Venom; Burn and scald; Skin infection carbuncle.

Fructus Tribuli: acrid in the mouth, hardship, slightly warm in nature, slightly poisonous; Return Liver Channel.Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight is antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.

Herba Ecliptae, sweet in the mouth, acid, cool in nature, return liver, kidney channel, liver and kidney tonifying; Cooling blood for hemostasis.Main deficiency of the liver and kindey; Have a dizzy spell; Early whitening of beard and hair; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Dysentery; Collapse; Leak; Traumatic hemorrhage.

Radix Polygoni Multiflori, bitter in the mouth, sweet; Puckery, slightly warm in nature, returns liver, kidney channel.Mainly contain nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, detoxify.Cure mainly blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid etc.

The traditional Chinese medical science is thought, sexual precosity appears in child, is imbalance of YIN and YANG, caused by the inverse unrest of QI and blood.Child is the body of " immature yin and yang ", all congenital full, and the child that the maintenance day after tomorrow is proper, himself negative and positive can arrive the development of harmonious balance, and its QI and blood is abundant, and mechanism of qi bar reaches, and passages through which vital energy circulates is unimpeded, and body can press human normal growth curve growth promoter.Otherwise work as imbalance of YIN and YANG, Kidney-Yin consumption wound, kidney-Yang is high prosperous, and QI and blood is disorderly inverse, and normal growth growth curve is upset, and just there will be sexual precosity.Therefore sexual precosity characteristic of disease is when for simulataneous insufficiency and excessive, disease located in liver, spleen, kidney, therefore should " tonifying for the deficiency, purging to treat the excess syndrome entangle that it is disorderly inverse during treatment.”。Therefore, the treatment of children's sexual precocity should be nursed one's health irritability from invigorating the spleen and regulating the stomach and be started with, and help and fall fire mutually with nourishing kidney-yin, damp eliminating is reduced phlegm, eliminating stagnation blood stasis dispelling.

In history, " precious mirror of hygiene " Sancai Fengsui Dan is made up of Radix Ginseng, Radix Asparagi, Radix Rehmanniae Preparata, Cortex Phellodendri, Fructus Amomi, Radix Glycyrrhizae, effect pathogenic fire purging consolidating YIN, controlling nocturnal emission with astringent drugs envelope marrow.For the disease such as emission, insomnia and dreamful sleep, soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, dry mouth and parching tongue of hyperactivity of fire caused by deficiency of YIN, hyperactivity of the ministerial fire, disturbing the essence-chamber.Radix Ginseng invigorating the spleen and replenishing QI in side; Radix Asparagi YIN nourishing tonifying the lung unboiled water; Radix Rehmanniae Preparata replenishing kidney-YIN; Cortex Phellodendri consolidating YIN lets out fire; Fructus Amomi is capable is stagnantly amusing; Radix Glycyrrhizae had both helped ginsenin QI invigorating to the greatest extent, the fraud that slow Cortex Phellodendri is bitter dry again.

The present invention is on the basis of " precious mirror of hygiene " Sancai Fengsui Dan ancient prescription, with the easy Radix Ginseng of Radix Salviae Miltiorrhizae, add Radix Ophiopogonis, Semen Euryales, Semen Ginkgo, Fructus Lycii, Fructus Ligustri Lucidi, Radix seu Herba Spiranthis Lanceae, Herba Ecliptae composition Sancai Fengsui Dan improvement side achieve significant effect for the treatment of children's sexual precocity; Radix Ophiopogonis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Ligustri Lucidi, Radix seu Herba Spiranthis Lanceae, Herba Ecliptae nourishing YIN to lower pathogenic fire in side, nourish blood Gu Jin; The deficiency of YIN is raw interior-heat then, therefore with Fructus Momordicae charantiae to rush down asthenic fire, admittedly rushing conception vessel with Semen Euryales, Semen Cuscutae, Radix Polygoni Multiflori, tonifying YIN increases liquid, invigorating middle warmer is dried, can be uncharmed water and mend true water, native lies prostrate fire with all YIN-tonifying drug with mending, especially can help to add essence, do not consider throw more and be humidified, to mend soil volt fire, with Fructus Crataegi spleen benefiting and stimulating the appetite, the Radix Glycyrrhizae blending property of medicine.

Chinese medicine composition of the present invention is by Herba Artemisiae Scopariae, Radix Aconiti Lateralis Preparata, Poria, Radix Ophiopogonis, Pericarpium Citri Reticulatae, Rhizoma Pinelliae, Fructus Aurantii, Periostracum Cicadae, Semen Euryales, Semen Ginkgo, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Asparagi, Radix Gentianae, Fructus Lycii, Herba Cistanches, Rhizoma Chuanxiong, Fructus Crataegi, Cortex Moutan, Fructus Gardeniae (parched), Pericarpium Trichosanthis, Concha Ostreae (calcined), Rhizoma Alismatis, Fructus Ligustri Lucidi, Cortex Lycii, Herba Portulacae, Radix Puerariae, Fructus Momordicae charantiae, Semen Cuscutae, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix seu Herba Spiranthis Lanceae, Fructus Tribuli, Herba Ecliptae, Radix Polygoni Multiflori forms, selected by this Chinese medicine composition, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is soothing liver and strengthening spleen dehumidifying, fire mutually falls in nourishing kidney-yin, effect of dissipating phlegm and resolving masses removing blood stasis, be applicable to deficiency of kidney-YIN, stagnation of liver-QI is damp and hot, the treatment of the children's sexual precocity of the multiple disease type such as combination of phlegm and heat, clinical therapeutic efficacy is obvious, short treating period, instant effect, safe without toxic side effect, wide popularization and application on clinic.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

The Chinese medicine composition of a kind for the treatment of precocious puberty of the present invention, get following traditional Chinese medicine raw medicine: Herba Artemisiae Scopariae 12 parts, Radix Aconiti Lateralis Preparata 16 parts, Semen Cuscutae 3 parts, Radix Ophiopogonis 12 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Pinelliae 9 parts, Radix Angelicae Sinensis 15 parts, 15 parts, Fructus Momordicae charantiae, 8 parts, Poria, Fructus Aurantii 5 parts, 3 parts, Radix Glycyrrhizae, Periostracum Cicadae 14 parts, Semen Euryales 9 parts, Semen Ginkgo 6 parts, 8 parts, Radix Rehmanniae Preparata, Cortex Lycii 5 parts, Radix Asparagi 1 part, Radix Gentianae 10 parts, Herba Portulacae 5 parts, Fructus Lycii 16 parts, Herba Cistanches 3 parts, Rhizoma Chuanxiong 11 parts, Radix Puerariae 10 parts, Fructus Crataegi 2 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 25 parts, Pericarpium Trichosanthis 20 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 16 parts, Fructus Ligustri Lucidi 10 parts, Radix Salviae Miltiorrhizae 4 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Fructus Tribuli 28 parts, Herba Ecliptae 13 parts, Radix Polygoni Multiflori 10 parts.

Embodiment 2:

The Chinese medicine composition of a kind for the treatment of precocious puberty of the present invention, get following traditional Chinese medicine raw medicine: Herba Artemisiae Scopariae 20 parts, Radix Aconiti Lateralis Preparata 10 parts, Semen Cuscutae 8 parts, Radix Ophiopogonis 5 parts, Pericarpium Citri Reticulatae 17 parts, Rhizoma Pinelliae 4 parts, Radix Angelicae Sinensis 20 parts, 10 parts, Fructus Momordicae charantiae, 12 parts, Poria, Fructus Aurantii 2 parts, 7 parts, Radix Glycyrrhizae, Periostracum Cicadae 11 parts, Semen Euryales 15 parts, Semen Ginkgo 3 parts, 13 parts, Radix Rehmanniae Preparata, Cortex Lycii 3 parts, Radix Asparagi 3 parts, Radix Gentianae 5 parts, Herba Portulacae 10 parts, Fructus Lycii 13 parts, Herba Cistanches 10 parts, Rhizoma Chuanxiong 7 parts, Radix Puerariae 12 parts, Fructus Crataegi 4 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 20 parts, Pericarpium Trichosanthis 18 parts, Concha Ostreae (calcined) 5 parts, Rhizoma Alismatis 12 parts, Fructus Ligustri Lucidi 5 parts, Radix Salviae Miltiorrhizae 3.5 parts, Radix seu Herba Spiranthis Lanceae 16 parts, Fructus Tribuli 30 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 5 parts.

Embodiment 3:

The Chinese medicine composition of a kind for the treatment of precocious puberty of the present invention, get following traditional Chinese medicine raw medicine: Herba Artemisiae Scopariae 13 parts, Radix Aconiti Lateralis Preparata 11 parts, Semen Cuscutae 4 parts, Radix Ophiopogonis 6 parts, Pericarpium Citri Reticulatae 13 parts, Rhizoma Pinelliae 5 parts, Radix Angelicae Sinensis 18 parts, 11 parts, Fructus Momordicae charantiae, 9 parts, Poria, Fructus Aurantii 4 parts, 6 parts, Radix Glycyrrhizae, Periostracum Cicadae 12 parts, Semen Euryales 13 parts, Semen Ginkgo 4 parts, 9 parts, Radix Rehmanniae Preparata, Cortex Lycii 4 parts, Radix Asparagi 2 parts, Radix Gentianae 6 parts, Herba Portulacae 6 parts, Fructus Lycii 14 parts, Herba Cistanches 5 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 7 parts, Fructus Crataegi 3 parts, Cortex Moutan 6 parts, Fructus Gardeniae (parched) 20 parts, Pericarpium Trichosanthis 16 parts, Concha Ostreae (calcined) 7 parts, Rhizoma Alismatis 18 parts, Fructus Ligustri Lucidi 6 parts, Radix Salviae Miltiorrhizae 3 parts, Radix seu Herba Spiranthis Lanceae 18 parts, Fructus Tribuli 18 parts, Herba Ecliptae 16 parts, Radix Polygoni Multiflori 3 parts.

Embodiment 4:

The Chinese medicine composition of a kind for the treatment of precocious puberty of the present invention, get following traditional Chinese medicine raw medicine: Herba Artemisiae Scopariae 17 parts, Radix Aconiti Lateralis Preparata 15 parts, Semen Cuscutae 7 parts, Radix Ophiopogonis 11 parts, Pericarpium Citri Reticulatae 16 parts, Rhizoma Pinelliae 8 parts, Radix Angelicae Sinensis 16 parts, 14 parts, Fructus Momordicae charantiae, 11 parts, Poria, Fructus Aurantii 3 parts, 5 parts, Radix Glycyrrhizae, Periostracum Cicadae 13 parts, Semen Euryales 14 parts, Semen Ginkgo 5 parts, 12 parts, Radix Rehmanniae Preparata, Cortex Lycii 3 parts, Radix Asparagi 1 part, Radix Gentianae 10 parts, Herba Portulacae 9 parts, Fructus Lycii 13 parts, Herba Cistanches 7 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 8 parts, Fructus Crataegi 2 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 30 parts, Pericarpium Trichosanthis 25 parts, Concha Ostreae (calcined) 6 parts, Rhizoma Alismatis 13 parts, Fructus Ligustri Lucidi 12 parts, Radix Salviae Miltiorrhizae 5 parts, Radix seu Herba Spiranthis Lanceae 13 parts, Fructus Tribuli 23 parts, Herba Ecliptae 15 parts, Radix Polygoni Multiflori 8 parts.

Embodiment 5:

The Chinese medicine composition of a kind for the treatment of precocious puberty of the present invention, get following traditional Chinese medicine raw medicine: Herba Artemisiae Scopariae 15 parts, Radix Aconiti Lateralis Preparata 12 parts, Semen Cuscutae 5 parts, Radix Ophiopogonis 9 parts, Pericarpium Citri Reticulatae 15 parts, Rhizoma Pinelliae 7 parts, Radix Angelicae Sinensis 19 parts, 13 parts, Fructus Momordicae charantiae, 10 parts, Poria, Fructus Aurantii 4 parts, 4 parts, Radix Glycyrrhizae, Periostracum Cicadae 11 parts, Semen Euryales 11 parts, Semen Ginkgo 5 parts, 10 parts, Radix Rehmanniae Preparata, Cortex Lycii 5 parts, Radix Asparagi 3 parts, Radix Gentianae 58 parts, Herba Portulacae 8 parts, Fructus Lycii 14 parts, Herba Cistanches 6 parts, Rhizoma Chuanxiong 9 parts, Radix Puerariae 9 parts, Fructus Crataegi 4 parts, Cortex Moutan 7 parts, Fructus Gardeniae (parched) 28 parts, Pericarpium Trichosanthis 22 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 15 parts, Fructus Ligustri Lucidi 5 parts, Radix Salviae Miltiorrhizae 3 parts, Radix seu Herba Spiranthis Lanceae 14 parts, Fructus Tribuli 16 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 7 parts.

Embodiment 6:

The Chinese medicine composition of a kind for the treatment of precocious puberty of the present invention, get following traditional Chinese medicine raw medicine: Herba Artemisiae Scopariae 19 parts, Radix Aconiti Lateralis Preparata 14 parts, Semen Cuscutae 6 parts, Radix Ophiopogonis 7 parts, Pericarpium Citri Reticulatae 14 parts, Rhizoma Pinelliae 6 parts, Radix Angelicae Sinensis 17 parts, 12 parts, Fructus Momordicae charantiae, 9 parts, Poria, Fructus Aurantii 4 parts, 4 parts, Radix Glycyrrhizae, Periostracum Cicadae 12 parts, Semen Euryales 10 parts, Semen Ginkgo 4 parts, 11 parts, Radix Rehmanniae Preparata, Cortex Lycii 4 parts, Radix Asparagi 1 part, Radix Gentianae 7 parts, Herba Portulacae 7 parts, Fructus Lycii 15 parts, Herba Cistanches 8 parts, Rhizoma Chuanxiong 8 parts, Radix Puerariae 11 parts, Fructus Crataegi 4 parts, Cortex Moutan 6 parts, Fructus Gardeniae (parched) 26 parts, Pericarpium Trichosanthis 20 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 16 parts, Fructus Ligustri Lucidi 10 parts, Radix Salviae Miltiorrhizae 4 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Fructus Tribuli 28 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 9 parts.

The Chinese medicine composition of the described sexual precosity of embodiment 1-6 can be made into the form of mixture, tablet, oral liquid, capsule or granule, also can be prepared into the different pharmaceutical such as honeyed pill, drop pill version.

Wherein, the preparation method of described mixture is:

Each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 1-6, add the water of 8 times of medical material gross weight, soak after 30-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the water of 10 times of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the water of 12 times of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, filtrate reduced in volume is to the extractum of relative density 1.1-1.15, this relative density is testing result at 60 c, adding ethanol to alcohol content is 75% (v/v), leave standstill 30-40 hour, get supernatant, decompression recycling ethanol concentrates, add water to 1000ml, stir evenly, subpackage, flowing steam sterilization 35min, obtain mixture.

The preparation method of described tablet is:

Each medical material of components by weight percent in the described Chinese medicine composition that Example 1-6 is arbitrary, with 50% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filters, and when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adding ethanol to alcohol content is 85% (v/v), leave standstill 24 hours, get supernatant, decompression recycling ethanol is to concentrated, vacuum drying, granulation, tabletting and get final product.

The preparation method of described capsule is:

Each medical material of components by weight percent in the described Chinese medicine composition that Example 1-6 is arbitrary, add the water of 10 times of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the water of 12 times of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the water of 14 times of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, filtrate reduced in volume is to the extractum of relative density 1.2-1.25, this relative density is testing result at 60 c, adding ethanol to alcohol content is 90% (v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulate, encapsulated and get final product.

The preparation method of described granule is:

In the described Chinese medicine composition that Example 1-6 is arbitrary, each medical material of components by weight percent, adds 8 times of water gagings, decocts 3 hours, leaches medicine juice; Add 6 times of water gagings again, decoct 2 hours, leach medicine juice; Merge secondary decocting liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, make alcohol content be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.

The preparation method of described oral liquid is:

In the described Chinese medicine composition that Example 1-6 is arbitrary, each medical material of components by weight percent, adds 9 times of water gagings, decocts 2 hours, leaches medicine juice; Add 10 times of water gagings again, decoct 3 hours, leach medicine juice; Merge secondary decocting liquid, when filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.15, adds ethanol, makes alcohol content be 50%, leave standstill 24 hours, filter, filtrate is concentrated into 2 times of medical material gross weight, adds adjuvant Mel, monoglycosides, benzoic acid, after stirring evenly fine straining, subpackage, sterilizing, obtained oral liquid.

Acute toxicity test:

Get mice 40, body weight 19-25 gram, be divided into 2 groups at random by body weight, treatment group and matched group: treatment group takes granule prepared by the embodiment of the present invention 4, and 0.43ml/10g body weight gastric infusion is pressed in fasting after 12 hours, dose 0.45g/ml, matched group takes distilled water, three times on the one, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other obviously abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.

Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical trial:

In order to verify the effect of Chinese medicine composition of the present invention, in May ,-2014 in January, 2013, under the guidance of Shandong pediatric hospital expert, the routine sexual precosity patient of outpatient service place Stochastic choice 104,4 ~ 11 years old age, wherein young girl 74 example, age at first visit was from 4 years old to 11 years old, wherein < 7 years old 21 example, 7 years old ~ 9 years old 42 example, 9 ~ 11 years old 11 example, finds that breast increases, the course of disease was from 3 days to 3 years, wherein < 3 months 17 examples, 3 ~ June 13 is routine, June ~ 1 year 27 examples, 1 year ~ 2 years 10 examples, > 2 years 7 examples.Breast increase is many by Tanner standard, makes Paederus fuscipes Curtis by stages with tenderness, wherein n phase 21 example, phase m phase 23, W phase 30 example.Large nympha increases and increases 37 examples with vaginal secretions, and menstrual onset 18 example is all irregular.Boy 30 example, during first visit age 10-12 year, the course of disease 13 example 2 years, 17 examples 3 years.According to Testicular Size and pubes distribution, by male sex characteristics Growth phrase, G2 phase 11 example, field phase 14 example, taste phase 5 example.There are 5 routine bimastisms to increase, belonged to for 11 phases.In addition the still sound change of tune thick, beard, penis increases thick easily erection, acne etc.

Inclusive criteria:

1. within 10 years old age of young girl's onset, in boy 12 years old;

2. except secondary sex characteristics, all there is the growth of sexual organ;

3. advanced more than 2 years of the stone age;

4. except, be secondary to the sexual precosity that maincenter tumor, wound etc. cause.

Inspection:

Uterus, ovary, testicular volume application Hitachi EVB-4D type two-dimensional ultrasound diagnostic apparatus measure, wherein uterus increase (> 2 milliliters) 59 example, it is routine that ovary increases (> 1 milliliter) 64, and it is routine that testis increases (> 3.5 milliliters) 27.

Bone-age determination gets left hand carpal bone normotopia X-ray film, by the measuring and calculating of TW2 method, and the acceleration 3 ~ 5.2 years compared with actual age of young girl's stone age, average 3.45 ± 0.71 years.Boy's stone age accelerates 2 ~ 2.5 years, average 2.13 ± 0.50 years.

Experimental study: 104 examples all take the granule of embodiments of the invention 3, morning and evening every day twice, each two bags, drug treatment 13 years, average 1.82.

74 routine young girls treat front and back Tanner aging schedule:

Grouping	I	II	III	IV
					Before treatment	0	21	23	30
After treatment	45	19	7	3

X2＝77.21，P＜0.001

74 routine young girl uterus and ovary treatment front and back change list:

*X2＝77.20，P＜0.001，**X2＝117.6，P＜0.001

Wherein, after treatment, mammary gland has and obviously reduces, and 45 examples (60.8%) have returned to child's type level, and after treatment, uterus and ovary all have obvious reduction, has mostly returned to the level corresponding to the age.

11 routine persons in the period are controlled all completely, and the 37 routine vaginal secretions persons of increasing have 36 examples disappear or reduce.Hyperactivity of fire caused by deficiency of YIN disease improves.

Stone age checks: 84 examples are grown simultaneously with the age or lower than age growth rate, 11 examples are still higher than age rate of rise.

Reduce to G1 phase 12 example by G3, G4 phase after 16 routine boy's treatments, G2 phase 4 example, the another 9 routine G2 phases subtract the G1 phase.Breast increases 5 examples, and 3 examples disappear, and 1 example reduces.Erection, acne all take a favorable turn.27 example stone ages and age grow simultaneously, and 3 examples are still higher than age rate of rise.

Result shows: do not improve after having 8 examples to take medicine in 104 examples, total effects reaches 92.3%.5 examples are had because sb.'s illness took a favorable turn from drug withdrawal, Relapse rate after causing in 8 invalid examples.

Conclusion: Chinese medicine composition of the present invention effectively can treat the sexual precosity disease of child, has significant therapeutic effect, is applicable to large-scale promotion application.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. a Chinese medicine composition for treating precocious puberty, is characterized in that: the crude drug of described Chinese medicine composition is made up of Herba Artemisiae Scopariae, Radix Aconiti Lateralis Preparata, Semen Cuscutae, Poria, Radix Ophiopogonis, Pericarpium Citri Reticulatae, Rhizoma Pinelliae, Fructus Aurantii, Periostracum Cicadae, Semen Euryales, Semen Ginkgo, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Asparagi, Radix Gentianae, Fructus Lycii, Herba Cistanches, Rhizoma Chuanxiong, Fructus Crataegi, Cortex Moutan, Fructus Gardeniae (parched), Pericarpium Trichosanthis, Concha Ostreae (calcined), Rhizoma Alismatis, Fructus Ligustri Lucidi, Cortex Lycii, Herba Portulacae, Radix Puerariae, Fructus Momordicae charantiae, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix seu Herba Spiranthis Lanceae, Fructus Tribuli, Herba Ecliptae, Radix Polygoni Multiflori.

2. the Chinese medicine composition for the treatment of precocious puberty according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 12-20 part, Radix Aconiti Lateralis Preparata 10-16 part, Semen Cuscutae 3-8 part, Radix Ophiopogonis 5-12 part, Pericarpium Citri Reticulatae 12-17 part, Rhizoma Pinelliae 4-9 part, Radix Angelicae Sinensis 15-20 part, Fructus Momordicae charantiae 10-15 part, Poria 8-12 part, Fructus Aurantii 2-5 part, Radix Glycyrrhizae 3-7 part, Periostracum Cicadae 11-14 part, Semen Euryales 9-15 part, Semen Ginkgo 3-6 part, Radix Rehmanniae Preparata 8-13 part, Cortex Lycii 3-5 part, Radix Asparagi 1-3 part, Radix Gentianae 5-10 part, Herba Portulacae 5-10 part, Fructus Lycii 13-16 part, Herba Cistanches 3-10 part, Rhizoma Chuanxiong 7-11 part, Radix Puerariae 7-12 part, Fructus Crataegi 2-4 part, Cortex Moutan 6-8 part, Fructus Gardeniae (parched) 20-30 part, Pericarpium Trichosanthis 16-25 part, Concha Ostreae (calcined) 4-7 part, Rhizoma Alismatis 12-18 part, Fructus Ligustri Lucidi 5-12 part, Radix Salviae Miltiorrhizae 3-5 part, Radix seu Herba Spiranthis Lanceae 13-20 part, Fructus Tribuli 16-30 part, Herba Ecliptae 13-16 part, Radix Polygoni Multiflori 3-10 part.

3. the Chinese medicine composition for the treatment of precocious puberty according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 12 parts, Radix Aconiti Lateralis Preparata 16 parts, Semen Cuscutae 3 parts, Radix Ophiopogonis 12 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Pinelliae 9 parts, Radix Angelicae Sinensis 15 parts, 15 parts, Fructus Momordicae charantiae, 8 parts, Poria, Fructus Aurantii 5 parts, 3 parts, Radix Glycyrrhizae, Periostracum Cicadae 14 parts, Semen Euryales 9 parts, Semen Ginkgo 6 parts, 8 parts, Radix Rehmanniae Preparata, Cortex Lycii 5 parts, Radix Asparagi 1 part, Radix Gentianae 10 parts, Herba Portulacae 5 parts, Fructus Lycii 16 parts, Herba Cistanches 3 parts, Rhizoma Chuanxiong 11 parts, Radix Puerariae 10 parts, Fructus Crataegi 2 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 25 parts, Pericarpium Trichosanthis 20 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 16 parts, Fructus Ligustri Lucidi 10 parts, Radix Salviae Miltiorrhizae 4 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Fructus Tribuli 28 parts, Herba Ecliptae 13 parts, Radix Polygoni Multiflori 10 parts.

4. the Chinese medicine composition for the treatment of precocious puberty according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 20 parts, Radix Aconiti Lateralis Preparata 10 parts, Semen Cuscutae 8 parts, Radix Ophiopogonis 5 parts, Pericarpium Citri Reticulatae 17 parts, Rhizoma Pinelliae 4 parts, Radix Angelicae Sinensis 20 parts, 10 parts, Fructus Momordicae charantiae, 12 parts, Poria, Fructus Aurantii 2 parts, 7 parts, Radix Glycyrrhizae, Periostracum Cicadae 11 parts, Semen Euryales 15 parts, Semen Ginkgo 3 parts, 13 parts, Radix Rehmanniae Preparata, Cortex Lycii 3 parts, Radix Asparagi 3 parts, Radix Gentianae 5 parts, Herba Portulacae 10 parts, Fructus Lycii 13 parts, Herba Cistanches 10 parts, Rhizoma Chuanxiong 7 parts, Radix Puerariae 12 parts, Fructus Crataegi 4 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 20 parts, Pericarpium Trichosanthis 18 parts, Concha Ostreae (calcined) 5 parts, Rhizoma Alismatis 12 parts, Fructus Ligustri Lucidi 5 parts, Radix Salviae Miltiorrhizae 3.5 parts, Radix seu Herba Spiranthis Lanceae 16 parts, Fructus Tribuli 30 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 5 parts.

5. the Chinese medicine composition for the treatment of precocious puberty according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 13 parts, Radix Aconiti Lateralis Preparata 11 parts, Semen Cuscutae 4 parts, Radix Ophiopogonis 6 parts, Pericarpium Citri Reticulatae 13 parts, Rhizoma Pinelliae 5 parts, Radix Angelicae Sinensis 18 parts, 11 parts, Fructus Momordicae charantiae, 9 parts, Poria, Fructus Aurantii 4 parts, 6 parts, Radix Glycyrrhizae, Periostracum Cicadae 12 parts, Semen Euryales 13 parts, Semen Ginkgo 4 parts, 9 parts, Radix Rehmanniae Preparata, Cortex Lycii 4 parts, Radix Asparagi 2 parts, Radix Gentianae 6 parts, Herba Portulacae 6 parts, Fructus Lycii 14 parts, Herba Cistanches 5 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 7 parts, Fructus Crataegi 3 parts, Cortex Moutan 6 parts, Fructus Gardeniae (parched) 20 parts, Pericarpium Trichosanthis 16 parts, Concha Ostreae (calcined) 7 parts, Rhizoma Alismatis 18 parts, Fructus Ligustri Lucidi 6 parts, Radix Salviae Miltiorrhizae 3 parts, Radix seu Herba Spiranthis Lanceae 18 parts, Fructus Tribuli 18 parts, Herba Ecliptae 16 parts, Radix Polygoni Multiflori 3 parts.

6. the Chinese medicine composition for the treatment of precocious puberty according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 17 parts, Radix Aconiti Lateralis Preparata 15 parts, Semen Cuscutae 7 parts, Radix Ophiopogonis 11 parts, Pericarpium Citri Reticulatae 16 parts, Rhizoma Pinelliae 8 parts, Radix Angelicae Sinensis 16 parts, 14 parts, Fructus Momordicae charantiae, 11 parts, Poria, Fructus Aurantii 3 parts, 5 parts, Radix Glycyrrhizae, Periostracum Cicadae 13 parts, Semen Euryales 14 parts, Semen Ginkgo 5 parts, 12 parts, Radix Rehmanniae Preparata, Cortex Lycii 3 parts, Radix Asparagi 1 part, Radix Gentianae 10 parts, Herba Portulacae 9 parts, Fructus Lycii 13 parts, Herba Cistanches 7 parts, Rhizoma Chuanxiong 10 parts, Radix Puerariae 8 parts, Fructus Crataegi 2 parts, Cortex Moutan 8 parts, Fructus Gardeniae (parched) 30 parts, Pericarpium Trichosanthis 25 parts, Concha Ostreae (calcined) 6 parts, Rhizoma Alismatis 13 parts, Fructus Ligustri Lucidi 12 parts, Radix Salviae Miltiorrhizae 5 parts, Radix seu Herba Spiranthis Lanceae 13 parts, Fructus Tribuli 23 parts, Herba Ecliptae 15 parts, Radix Polygoni Multiflori 8 parts.

7. the Chinese medicine composition for the treatment of precocious puberty according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 15 parts, Radix Aconiti Lateralis Preparata 12 parts, Semen Cuscutae 5 parts, Radix Ophiopogonis 9 parts, Pericarpium Citri Reticulatae 15 parts, Rhizoma Pinelliae 7 parts, Radix Angelicae Sinensis 19 parts, 13 parts, Fructus Momordicae charantiae, 10 parts, Poria, Fructus Aurantii 4 parts, 4 parts, Radix Glycyrrhizae, Periostracum Cicadae 11 parts, Semen Euryales 11 parts, Semen Ginkgo 5 parts, 10 parts, Radix Rehmanniae Preparata, Cortex Lycii 5 parts, Radix Asparagi 3 parts, Radix Gentianae 58 parts, Herba Portulacae 8 parts, Fructus Lycii 14 parts, Herba Cistanches 6 parts, Rhizoma Chuanxiong 9 parts, Radix Puerariae 9 parts, Fructus Crataegi 4 parts, Cortex Moutan 7 parts, Fructus Gardeniae (parched) 28 parts, Pericarpium Trichosanthis 22 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 15 parts, Fructus Ligustri Lucidi 5 parts, Radix Salviae Miltiorrhizae 3 parts, Radix seu Herba Spiranthis Lanceae 14 parts, Fructus Tribuli 16 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 7 parts.

8. the Chinese medicine composition for the treatment of precocious puberty according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Artemisiae Scopariae 19 parts, Radix Aconiti Lateralis Preparata 14 parts, Semen Cuscutae 6 parts, Radix Ophiopogonis 7 parts, Pericarpium Citri Reticulatae 14 parts, Rhizoma Pinelliae 6 parts, Radix Angelicae Sinensis 17 parts, 12 parts, Fructus Momordicae charantiae, 9 parts, Poria, Fructus Aurantii 4 parts, 4 parts, Radix Glycyrrhizae, Periostracum Cicadae 12 parts, Semen Euryales 10 parts, Semen Ginkgo 4 parts, 11 parts, Radix Rehmanniae Preparata, Cortex Lycii 4 parts, Radix Asparagi 1 part, Radix Gentianae 7 parts, Herba Portulacae 7 parts, Fructus Lycii 15 parts, Herba Cistanches 8 parts, Rhizoma Chuanxiong 8 parts, Radix Puerariae 11 parts, Fructus Crataegi 4 parts, Cortex Moutan 6 parts, Fructus Gardeniae (parched) 26 parts, Pericarpium Trichosanthis 20 parts, Concha Ostreae (calcined) 4 parts, Rhizoma Alismatis 16 parts, Fructus Ligustri Lucidi 10 parts, Radix Salviae Miltiorrhizae 4 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Fructus Tribuli 28 parts, Herba Ecliptae 14 parts, Radix Polygoni Multiflori 9 parts.

9. according to the Chinese medicine composition of the arbitrary described treating precocious puberty of claim 2-8, it is characterized in that: described Chinese medicine composition makes mixture, tablet, oral liquid, capsule or granule, wherein said mixture, tablet, oral liquid, capsule, granule are prepared by the following method:

The preparation method of described mixture is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, add the water of 8 times of medical material gross weight, soak after 30-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the water of 10 times of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the water of 12 times of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, filtrate reduced in volume is to the extractum of relative density 1.1-1.15, this relative density is testing result at 60 c, adding ethanol to alcohol content is 75% (v/v), leave standstill 30-40 hour, get supernatant, decompression recycling ethanol concentrates, add water to 1000ml, stir evenly, subpackage, flowing steam sterilization 35min, obtain mixture,

The preparation method of described tablet is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, with 50% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adding ethanol to alcohol content is 85% (v/v), leave standstill 24 hours, get supernatant, decompression recycling ethanol is to concentrated, vacuum drying, granulation, tabletting and get final product;

The preparation method of described capsule is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, add the water of 10 times of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the water of 12 times of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the water of 14 times of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, filtrate reduced in volume is to the extractum of relative density 1.2-1.25, this relative density is testing result at 60 c, adding ethanol to alcohol content is 90% (v/v), leave standstill 24 hours, get supernatant, reclaim ethanol to concentrated, vacuum drying, granulate, encapsulated and get final product,

The preparation method of described granule is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, adds 8 times of water gagings, decocts 3 hours, leaches medicine juice; Add 6 times of water gagings again, decoct 2 hours, leach medicine juice; Merge secondary decocting liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, make alcohol content be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule;

The preparation method of described oral liquid is: each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 2-7, adds 9 times of water gagings, decocts 2 hours, leaches medicine juice; Add 10 times of water gagings again, decoct 3 hours, leach medicine juice; Merge secondary decocting liquid, when filtrate is concentrated into 80 DEG C, relative density is the clear paste of 1.15, adds ethanol, makes alcohol content be 50%, leave standstill 24 hours, filter, filtrate is concentrated into 2 times of medical material gross weight, adds adjuvant Mel, monoglycosides, benzoic acid, after stirring evenly fine straining, subpackage, sterilizing, obtained oral liquid.

10. the application of Chinese medicine composition in treating precocious puberty medicine of the treating precocious puberty as described in as arbitrary in claim 1-9.