CN104688653A - Whitening skin lotion and preparation method thereof - Google Patents
Whitening skin lotion and preparation method thereof Download PDFInfo
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- CN104688653A CN104688653A CN201510117336.0A CN201510117336A CN104688653A CN 104688653 A CN104688653 A CN 104688653A CN 201510117336 A CN201510117336 A CN 201510117336A CN 104688653 A CN104688653 A CN 104688653A
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Abstract
The invention relates to the field of cosmetics, and specifically relates to whitening skin lotion and a preparation method thereof. The whitening skin lotion is prepared from the following components: pearl powder, a pearl extract, a glycyrrhiza glabra water solution, hydrolyzed conchiolin protein, a pisum sativum extract, glycerinum and xanthan gum; the pearl powder content and the pearl extract are synchronously used; the glycyrrhiza glabra water solution contains 0.5 to 5.0% of a glycyrrhiza glabra extract. According to the whitening skin lotion, the pearl powder is a nutritional functional ingredient good for human skin; the whitening skin lotion can improve the barrier function of the skin, is able to moisture the skin and increase the degree of hydration of the skin, and has an obvious effect on inhibiting activity of tyrosinase; the study shows that the pearl powder is high in free radical inhibiting and removing capacity.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of whitening and skin-protecting water and preparation method thereof.
Background technology
The type of the melanin (melanin) that the colour of skin of people, hair color and eye color mainly synthesize with melanocyte (melanocyte), quantity are relevant with distribution.In melanocyte, be subject to the catalytic action of tryrosinase, tyrosine is successively oxidized to DOPA and DOPA quinone, and DOPA quinone changes into dopachrome again further; Under DHI enzyme and dopachrome interconvertible enzyme and the oxidasic catalytic action respectively of DHICA, dopachrome is further converted to 5,6-istain and 5,6-istain-2-carboxylic acid through 5,6-dihydroxy indole and 5,6-dihydroxy indole-2-carboxylic acid; 5,6-istain and 5,6-istain-2-carboxylic acid are finally polymerized formation melanin.Tryrosinase is first step rate-limiting enzyme and the key enzyme of B16 cell.Therefore, all tyrosinase inhibitor is contained in most of whitening agent.
Containing the pigment cell of 4% ~ 5% in the basal layer cell of human epidermal.The color of human skin is not depend on melanocyte quantity, but depends on the quantity of melanosome, size, distribution and melanocyte degree.Therefore, some whitening composition is by affecting formation, the maturation of melanosome and shifting the effect reaching whitening.
Under ultraviolet radiation, keratinocyte can discharge Endothelin, when after the receptors bind on Endothelin and melanocyte film, the propagation of meeting stimulation melanin cell, activate the activity of tryrosinase, accelerate the growth of melanocyte dendritic processes, thus accelerate the migration to keratinocyte of melanic synthesis and melanosome.Therefore, the melanism effect of ultraviolet to skin is effectively suppressed will to block keratinocyte to melanocyte transmission of information.Therefore, endothelin antagonist also becomes the important whitening agent of a class gradually.
The reason formed due to melanin is many-sided, and Beauty of Product white effect be made remarkable, must consider the reason that melanin is formed by Comprehensive, only in this way can design efficient whitening product.But multipath acts on melanic generation and transfer process, the safety of product, stability and outward appearance must be considered.Therefore, select have multi-functional, stable, safety and light-colored whitening raw material, play its collaborative whitening function, have great importance.
Summary of the invention
The present invention has considered the melanic various factors of formation, an object of the present invention is to propose a kind of whitening and skin-protecting water.This whitening and skin-protecting water is main active component with the biological enzymolysis product of multiple natural extract and natural extract, works in coordination with and plays a role, and check melanin generates and moves the effect reaching skin whitening.Another object of the present invention is the preparation method proposing above-mentioned whitening and skin-protecting water.
In order to realize first above-mentioned object, present invention employs following technical scheme:
A kind of whitening and skin-protecting water, said composition comprises following component by mass percentage:
Margarita powder 0 ~ 30%
Margarita extract 0 ~ 10%
Glycyrrhiza glabra L. aqueous solution 0.1 ~ 10%
Hydrolysis conchiolin 0.005 ~ 1%
Semen Pisi sativi extract 0.1 ~ 5%
Glycerol 1.0 ~ 8%
Xanthan gum 0.01 ~ 0.5%;
Be zero when above-mentioned Margarita powder is different with the content of Margarita extract, and in described Glycyrrhiza glabra L. aqueous solution, the percentage composition of Glycyrrhiza glabra L. extract is 0.5 ~ 5.0%.
As preferably, said composition comprises following component by mass percentage:
Margarita powder 0.5 ~ 20%
Margarita extract 0.5 ~ 5%
Glycyrrhiza glabra L. aqueous solution 0.3 ~ 3%
Hydrolysis conchiolin 0.01 ~ 0.3%
Semen Pisi sativi extract 0.5 ~ 3%
Glycerol 2.0 ~ 7.0%
Xanthan gum 0.05 ~ 0.3%.
As preferably, said composition comprises following component by mass percentage:
Margarita powder 1.0 ~ 15%
Margarita extract 1.0 ~ 4%
Glycyrrhiza glabra L. aqueous solution 0.5 ~ 3%
Hydrolysis conchiolin 0.05 ~ 0.2%
Semen Pisi sativi extract 1.0 ~ 2.5%
Glycerol 3.0 ~ 6.0%
Xanthan gum 0.05 ~ 0.2%.
As preferably, in described Glycyrrhiza glabra L. aqueous solution, the percentage composition of Glycyrrhiza glabra L. extract is 1.0 ~ 3.0%.
As preferably, described Glycyrrhiza glabra L. aqueous solution is scattered in water by Glycyrrhiza glabra L. extract after hydroxypropyl cyclodextrin envelope, and add the solution that 1,2-pentanediol is formed, in Glycyrrhiza glabra L. extract, glabridin mass fraction is greater than 90%.
As preferably, described Margarita powder is that Margarita grinds 1000 ~ 3000 order flours obtained through physical mechanical.
As preferably, the described Margarita extract multiple peptide class that to be Margarita powder obtain through enzymolysis and amino acid whose mixture.
As preferably, the described hydrolysis conchiolin powdered substance that to be hydrobiological conchiolin obtain through the mode of biological enzymolysis, quality purity is greater than 70%.
As preferably, described Semen Pisi sativi extract quality purity is 2 ~ 3%.
In order to realize second above-mentioned object, present invention employs following technical scheme:
Prepare a method for above-mentioned whitening and skin-protecting water, the method comprises the following steps:
1) add in reaction pot by water, glycerol and xanthan gum, open and stir, be heated to 75 ~ 80 DEG C, dispersed with stirring is even;
2) open cooling circulating water, stir cooling, when temperature is down to 45 ~ 50 DEG C, add Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract and antiseptic add in reaction pot, stirring and dissolving is complete;
3) continuing stirring is cooled to lower than 30 ~ 40 DEG C, stops stirring, terminates.
Margarita powder in this whitening and skin-protecting water is the good nutritive effect composition of one of human body skin.It can improve the barrier function of skin, can also skin care, increases the degree of hydration of skin, goes out inhibitory action significantly to the activities present of tryrosinase.Further, there are some researches show that Margarita powder has very strong suppression and removes the ability of free radical.
Margarita extract in this whitening and skin-protecting water contains Margarita native polypeptide and multiple necessary aminoacid, Margarita native polypeptide has the effect suppressing Endothelin to activate tryrosinase and suppression Endothelin promotion Differentiation of Melanocytes, and aminoacid can promote that Skin Cell increases, restraint of tyrosinase promotes to generate the multi abilities such as melanin activity, scavenging free radicals.
Active component in Glycyrrhiza glabra L. aqueous solution in this whitening and skin-protecting water is glabridin, glabridin has significant antiinflammatory and whitening effect, in the world glabridin is published as check and approve license, one of the safest, most whitening effect composition, be the whitening gold that industry is generally acknowledged, exist only in the root of Glycyrrhiza glabra L..But find in the application, the low mixture strip of glabridin purity has color and luster, and under temperature high condition color burn, have impact to the color and luster of cosmetics like this.And glabridin content is not less than 90% in the Glycyrrhiza glabra L. extract adopted in the present invention, therefore in use less for cosmetic color impact.In addition, water-soluble formation aqueous solution after this product employing hydroxypropyl cyclodextrin envelope, easy to use.
Hydrolysis conchiolin in this whitening and skin-protecting water is a kind of endothelin antagonist, and endothelin antagonist is a kind of natural whiting additive of extracting and developing and purification from natural product.After the mid-90 skin physiology scholar finder body skin is irradiated by ultraviolet (UVB), epithelial cells discharges Endothelin, the information of this Endothelin is by after the receptor acceptance on melanocyte film, have stimulated the differentiation of melanocyte, propagation activate the activity of tryrosinase, thus melanin sharply increases.Endothelin antagonist can preferentially and the receptors bind of melanocyte film, make Endothelin ineffective, thus suppress the propagation of the melanocyte caused because ultraviolet radiation causes Endothelin to discharge and melanic synthesis, and play whitening function by suppressing keratinocyte release Endothelin, be safety, efficiently whitening agent.
Semen Pisi sativi extract in this whitening and skin-protecting water can suppress the activity of Pmel 17 protein gene, and Pmel 17 is key genes of melanosome maturation.Melanic generation can be reduced from source like this, and there is effect of whitening and light speckle.
Accompanying drawing explanation
Fig. 1 experimenter's face-image example.
Detailed description of the invention
Skin whitening whitening and skin-protecting water provided by the invention be with Margarita powder or Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract for main component, be aided with cosmetics and commonly use matrix components emulsifying agent, emollient, wetting agent, thickening agent, antiseptic, essence and water and make.The present invention will be described to enumerate a part of specific embodiment below, but do not limit content of the present invention.
Detailed description of the invention
embodiment 1
Whitening and skin-protecting water:
The component and the relative content thereof that form above-mentioned whitening and skin-protecting water are:
| Glycerol | 5 |
| Xanthan gum | 0.1 |
| Margarita extract | 2 |
| Glycyrrhiza glabra L. aqueous solution | 2 |
| Hydrolysis conchiolin | 0.05 |
| Semen Pisi sativi extract | 1 |
| Antiseptic | 0.8 |
| Water | Surplus |
The preparation method of above-mentioned whitening and skin-protecting water, comprises the following steps: water, glycerol and xanthan gum to add in reaction pot, and open and stir, be heated to 75 ~ 80 DEG C, dispersed with stirring is even; Open cooling circulating water, stir cooling, when temperature is down to 45 ~ 50 DEG C, add Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract and antiseptic add in reaction pot, stirring and dissolving is complete; Continuing stirring is cooled to lower than 38 DEG C, stops stirring, terminates.
embodiment 2
The component and the relative content thereof that form above-mentioned whitening and skin-protecting water are:
| Glycerol | 1.5 |
| Xanthan gum | 0.2 |
| Margarita extract | 1 |
| Margarita powder | 15 |
| Glycyrrhiza glabra L. aqueous solution | 3 |
| Hydrolysis conchiolin | 0.02 |
| Semen Pisi sativi extract | 2 |
| Antiseptic | 0.5 |
| Water | Surplus |
The preparation method of above-mentioned whitening and skin-protecting water, comprises the following steps: water, glycerol and xanthan gum to add in reaction pot, and open and stir, be heated to 75 ~ 80 DEG C, dispersed with stirring is even; Open cooling circulating water, stir cooling, when temperature is down to 45 ~ 50 DEG C, add Margarita extract, Margarita powder, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract and antiseptic add in reaction pot, stirring and dissolving is complete; Continuing stirring is cooled to lower than 38 DEG C, stops stirring, terminates.
embodiment 3
The component and the relative content thereof that form above-mentioned whitening and skin-protecting water are:
| Glycerol | 1.5 |
| Xanthan gum | 0.2 |
| Margarita powder | 20 |
| Glycyrrhiza glabra L. aqueous solution | 6 |
| Hydrolysis conchiolin | 0.1 |
| Semen Pisi sativi extract | 0.5 |
| Antiseptic | 0.5 |
| Water | Surplus |
The preparation method of above-mentioned whitening and skin-protecting water, comprises the following steps: water, glycerol and xanthan gum to add in reaction pot, and open and stir, be heated to 75 ~ 80 DEG C, dispersed with stirring is even; Open cooling circulating water, stir cooling, when temperature is down to 45 ~ 50 DEG C, add Margarita powder, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract and antiseptic add in reaction pot, stirring and dissolving is complete; Continuing stirring is cooled to lower than 38 DEG C, stops stirring, terminates.
embodiment 4
The component and the relative content thereof that form above-mentioned whitening and skin-protecting water are:
| Glycerol | 5.0 |
| Xanthan gum | 0.1 |
| Margarita extract | 1.5 |
| Margarita powder | 10 |
| Glycyrrhiza glabra L. aqueous solution | 2.5 |
| Hydrolysis conchiolin | 0.1 |
| Semen Pisi sativi extract | 1.5 |
| Antiseptic | 0.5 |
| Water | Surplus |
The preparation method of above-mentioned whitening and skin-protecting water, comprises the following steps: water, glycerol and xanthan gum to add in reaction pot, and open and stir, be heated to 75 ~ 80 DEG C, dispersed with stirring is even; Open cooling circulating water, stir cooling, when temperature is down to 45 ~ 50 DEG C, add Margarita extract, Margarita powder, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract and antiseptic add in reaction pot, stirring and dissolving is complete; Continuing stirring is cooled to lower than 38 DEG C, stops stirring, terminates.
embodiment 5whitening effect is evaluated
The whitening and skin-protecting water provided in this experimental selection embodiment 2 carries out clinical experiment.
This experiment comprises 23 volunteers, and female age is in 23-50 one full year of life, and face has the speckle caused due to Exposure to Sunlight, operating pressure, age etc.Tested material is used and all information by regulation at duration of test.Every day smears whitening and skin-protecting water for twice sooner or later, and test period is 4 weeks.Before W0(uses), W2 (using 2 weeks), W4(use 4 weeks) obtain face image data by VISIA-CR, and with the change of the facial particular spots L* value of SSA software analysis, and check its diversity with t.Its result is as follows:
1. L-value change list
Note: * * represents difference highly significant (P<0.01)
Can see from table, can see that use is after two weeks, skin colourity L* value just has increase trend, and the level be obviously greater than before use, difference has statistical significance (p<0.01), after illustrating that face uses whitening and skin-protecting water, skin color shoal gradually and mottle color thin out gradually.
As can see from Figure 1, when W2, blee obviously highlights, and can have a good maintenance effect when W4.Be consistent with the L-value result of face.
2. volunteer's self evaluation
Adopt questionnaire form, the degree that before and after being used by experimenter's self-assessment product, the skin color depth and spot size change judges that product improves degree to skin.Wherein without improvement refer to mottle size unchanged/colour of skin is unchanged; Slight improvement refers to that mottle slightly reduces, thin out/overall colour of skin highlights to some extent; Moderate improvement refers to that mottle obviously reduces, and thin out/overall colour of skin obviously highlights.Use in sample E surrounding, what experimenter thought that blee moderate improves account for 38% of total number of persons, is slightly improved as 54%; And in mottle improvement, what think that moderate improves is 15%, slight improvement account for 77%.
In sum, this whitening product has significant white-skinned face function, namely has the double effects of bright color and desalination mottle.
Claims (10)
1. a whitening and skin-protecting water, is characterized in that this whitening and skin-protecting water comprises following component by mass percentage:
Margarita powder 0 ~ 30%
Margarita extract 0 ~ 10%
Glycyrrhiza glabra L. aqueous solution 0.1 ~ 10%
Hydrolysis conchiolin 0.005 ~ 1%
Semen Pisi sativi extract 0.1 ~ 5%
Glycerol 1.0 ~ 8%
Xanthan gum 0.01 ~ 0.5%;
Be zero when above-mentioned Margarita powder is different with the content of Margarita extract, and in described Glycyrrhiza glabra L. aqueous solution, the percentage composition of Glycyrrhiza glabra L. extract is 0.5 ~ 5.0%.
2. a kind of whitening and skin-protecting water according to claim 1, is characterized in that said composition comprises following component by mass percentage:
Margarita powder 0.5 ~ 20%
Margarita extract 0.5 ~ 5%
Glycyrrhiza glabra L. aqueous solution 0.3 ~ 3%
Hydrolysis conchiolin 0.01 ~ 0.3%
Semen Pisi sativi extract 0.5 ~ 3%
Glycerol 2.0 ~ 7.0%
Xanthan gum 0.05 ~ 0.3%.
3. a kind of whitening and skin-protecting water according to claim 1, is characterized in that said composition comprises following component by mass percentage:
Margarita powder 1.0 ~ 15%
Margarita extract 1.0 ~ 4%
Glycyrrhiza glabra L. aqueous solution 0.5 ~ 3%
Hydrolysis conchiolin 0.05 ~ 0.2%
Semen Pisi sativi extract 1.0 ~ 2.5%;
Glycerol 3.0 ~ 6.0%
Xanthan gum 0.05 ~ 0.2%.
4. a kind of whitening and skin-protecting water according to claim 1 or 2 or 3, is characterized in that the percentage composition of Glycyrrhiza glabra L. extract in described Glycyrrhiza glabra L. aqueous solution is 1.0 ~ 3.0%.
5. a kind of whitening and skin-protecting water according to claim 4, it is characterized in that described Glycyrrhiza glabra L. aqueous solution is scattered in water by Glycyrrhiza glabra L. extract after hydroxypropyl cyclodextrin envelope, add 1, the solution that 2-pentanediol is formed, in Glycyrrhiza glabra L. extract, glabridin mass fraction is greater than 90%.
6. a kind of whitening and skin-protecting water according to claim 1 or 2 or 3, is characterized in that described Margarita powder is that Margarita grinds 1000 ~ 3000 order flours obtained through physical mechanical.
7. a kind of whitening and skin-protecting water according to claim 1 or 2 or 3, is characterized in that the described Margarita extract multiple peptide class that to be Margarita powder obtain through enzymolysis and amino acid whose mixture.
8. a kind of whitening and skin-protecting water according to claim 1 or 2 or 3, it is characterized in that the described hydrolysis conchiolin powdered substance that to be hydrobiological conchiolin obtain through the mode of biological enzymolysis, quality purity is greater than 70%.
9. a kind of whitening and skin-protecting water according to claim 1 or 2 or 3, is characterized in that described Semen Pisi sativi extract quality purity is 2 ~ 3%.
10. prepare a method for the whitening and skin-protecting water described in claim 1 ~ 9 any one claim, it is characterized in that the method comprises the following steps:
1) add in reaction pot by water, glycerol and xanthan gum, open and stir, be heated to 75 ~ 80 DEG C, dispersed with stirring is even;
2) open cooling circulating water, stir cooling, when temperature is down to 45 ~ 50 DEG C, add Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract and antiseptic add in reaction pot, stirring and dissolving is complete;
3) continuing stirring is cooled to lower than 30 ~ 40 DEG C, stops stirring, terminates.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510117336.0A CN104688653A (en) | 2015-03-17 | 2015-03-17 | Whitening skin lotion and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510117336.0A CN104688653A (en) | 2015-03-17 | 2015-03-17 | Whitening skin lotion and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042473A (en) * | 2017-12-27 | 2018-05-18 | 广西还珠海洋生物科技有限公司 | A kind of surfactant containing pearl |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004123563A (en) * | 2002-09-30 | 2004-04-22 | Iskra Ind Co Ltd | Cosmetic containing fruit oil obtained from hippophae and ingredients extracted from other galenicals |
| CN104042547A (en) * | 2014-06-16 | 2014-09-17 | 诺斯贝尔(中山)无纺日化有限公司 | Whitening and moistening silk facial mask essence containing lecithin |
-
2015
- 2015-03-17 CN CN201510117336.0A patent/CN104688653A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004123563A (en) * | 2002-09-30 | 2004-04-22 | Iskra Ind Co Ltd | Cosmetic containing fruit oil obtained from hippophae and ingredients extracted from other galenicals |
| CN104042547A (en) * | 2014-06-16 | 2014-09-17 | 诺斯贝尔(中山)无纺日化有限公司 | Whitening and moistening silk facial mask essence containing lecithin |
Non-Patent Citations (1)
| Title |
|---|
| 刘华钢: "《中药化妆品学》", 30 November 2005, 中国中医药出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042473A (en) * | 2017-12-27 | 2018-05-18 | 广西还珠海洋生物科技有限公司 | A kind of surfactant containing pearl |
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Application publication date: 20150610 |