CN104688554A - Application of saligenin in preparation of mouth care healthcare product - Google Patents
Application of saligenin in preparation of mouth care healthcare product Download PDFInfo
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- CN104688554A CN104688554A CN201510049072.XA CN201510049072A CN104688554A CN 104688554 A CN104688554 A CN 104688554A CN 201510049072 A CN201510049072 A CN 201510049072A CN 104688554 A CN104688554 A CN 104688554A
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Abstract
The invention discloses application of saligenin in preparation of a mouth care healthcare product and relates to the technical field of mouth care. The saligenin is used as a unique active component with an analgesic and anti-inflammatory effect to be added in the mouth care healthcare product in a process of preparing the mouth care healthcare product. The saligenin is safe to use in the mouth care healthcare products such as toothpaste, mouth wash, tooth powder, throat lozenge and chewing gum and has an obvious analgesic and anti-inflammatory effect.
Description
Technical field
The present invention relates to oral care techniques field, especially a kind of oral cavity nursing health products with assisting in preventing and treating gingivitis and tooth, gingiva pain.
Background technology
The oral care product that people commonly use is toothpaste, collutory, dentifrice, throat lozenge, chewing gum etc. mainly, and its basic function is exactly cleaning teeth, and protection gingiva, safeguards the hygiene and health in oral cavity.Along with the raising of people's living standard, the health care consciousness of consumer constantly strengthens, more requirement be it is also proposed to oral care product, the requirement of people to toothpaste and collutory also add effect that some can assist prevention oral disease except having this basic function that cleans the teeth, therefore, toothpaste in the market and collutory almost all add the functional component for the various oral disease of control, therefore the product that oral care product both domestic and external has a various functional type becomes the market mainstream, is mostly wherein to add western medicine composition to realize.
But along with the development of economy, along with day by day manifesting of the problem such as environmental pollution, ecological disturbance, the safety of consumer to product is more and more paid close attention to, thus more and more advocates natural and safe product.Interpolation effectively can prevent and treat the oral care product of the natural plant active component of various oral disease, little with its toxic and side effects, and the feature of green, environmental protection, safety, is more and more subject to the favor of consumer.
Gingivitis, toothache are the oral diseases caused by many reasons; show according to interrelated data; China has consumer more than more than 50% to there is toothache in various degree at different times, gingivitis be then most consumer often can or light or retransmit raw a kind of oral disease.
At present, anti-inflammation hemostasia analgesia class Chinese herbal toothpaste on the market, various in style, the medicinal herb components of interpolation is also different, and as Radix Zanthoxyli, Herba Pileae Scriptae, Flos Lonicerae, Flos Chrysanthemi Indici etc., part Chinese herbal toothpaste really can play the gingiva that takes care of one's teeth, the effect of anti-inflammatory analgesic.But the effective ingredient proportioning of some toothpaste is also improper, and the actual effect played is very limited, really can not improve oral problem.
Summary of the invention
The problem that the present invention solves is to provide salicin and is preparing the application scheme in oral cavity nursing health products, and this oral cavity nursing health products has obvious anti-inflammatory analgesic action.
Salicin of the present invention is exactly joined in toothpaste, collutory, dentifrice, throat lozenge, chewing gum oral cavity nursing health products by the sole active agent of salicin as anti-inflammatory analgesic action in the technique preparing oral cavity nursing health products preparing the application scheme in oral cavity nursing health products.
In technique scheme, described salicin can join in toothpaste as the sole active agent of anti-inflammatory analgesic action, and the percentage by weight of described salicin in total mastic of toothpaste is 0.11 ~ 5.0%.
In such scheme, described salicin can join in collutory as the sole active agent of anti-inflammatory analgesic action, and the percentage by weight of described salicin in the raw material of collutory is 0.11 ~ 5.0%.
In such scheme, described salicin joins in dentifrice as the sole active agent of anti-inflammatory analgesic action, and the percentage by weight of described salicin in dentifrice raw material is 0.11 ~ 5.0%.
In such scheme, described salicin joins in throat lozenge as the sole active agent of anti-inflammatory analgesic action, and the percentage by weight of described salicin in throat lozenge raw material is 0.11 ~ 5.0%.
In such scheme, described salicin joins in chewing gum as the sole active agent of anti-inflammatory analgesic action, and the percentage by weight of described salicin in chewing-gum material is 0.11 ~ 5.0%.
The natural active products that branch or bark extract that the said salicin of the present invention is Liu Ke plant Salix babylonica L. Salix babylonica L. extract, Ramulus Salicis Babylonicae nature and flavor are pungent, bitter, cold, function dispelling wind and heat pathogens, removing damp-heat, reducing swelling and alleviating pain.Salicin is one of active component that in Ramulus Salicis Babylonicae or Willow bark, content is very high, and the salicin extracted from Ramulus Salicis Babylonicae or Willow bark has antipyretic and analgesic activity.
Salicin of the present invention uses existing commercially available extracting and purified product from Ramulus Salicis Babylonicae or Willow bark, and the content of its salicin is more than 50%.
The consumption of the salicin described in the present invention is all the pure extract powder of 100% for active component, but is not limited to pure extract powder, also can be other form such as extracting solution or extractum.In time being applied to oral care product with other forms as extracting solution, the addition in formula should be converted to the amount of pure form of extract disclosed in the present invention.
Oral cavity nursing health products in the present invention is applied to wherein with the form of single medicinal material by salicin.
Mouth care health product of the present invention adds the raw material not only use safety of salicin as natural plant active component in preparation process, and has obvious anti-inflammatory analgesic action.
(xylol causes the antiinflammatory action of white mice auricle acute inflammation swelling to the antiinflammation of white mice to adopt toothpaste sample of the present invention
(1).)
Choose body weight 18 ~ 22g healthy Kunming kind ♂ white mice 70, divide equally 7 groups at random, often organize 10.Blank group (normal saline 0.1ml/ only), toothpaste bare substrate group (toothpaste bare substrate 0.1g/ only), fluocinonide cream group (fluocinonide cream 0.1g/only), toothpaste sample No. 1 group, toothpaste sample No. 2 groups, toothpaste sample No. 3 groups, toothpaste sample No. 4 groups.Respectively organize two sides uniform application dimethylbenzene 0.1ml inside and outside every animal auris dextra exterior feature/only cause inflammation during experiment, left ear does not add process and does self-blank contrast.After smearing dimethylbenzene 30min, uniform application group tested material sample 0.1g/ respectively, two sides inside and outside each group every animal auris dextra exterior feature.After giving tested material 1h, white mice cervical dislocation is put to death, cut two auricles, wash away the wide tested material sample of auris dextra with normal saline, dry cotton ball is cleaned, overlapping two auricles, two circle auricles are got at same position cutter with the card punch of internal diameter 8mm, weigh on FA1004 type electronic analytical balance respectively, it is swelling value that auris dextra sheet weight deducts left auricle weight, and data carry out statistics t inspection.The results are shown in Table 1.
table 1: containing white mice auricle acute inflammation swelling caused by salicin toothpaste sample xylol impact (
± S, n=10)
Note: compare with blank group: #P < 0.05, ##P < 0.01, ###P < 0.001, ▲ P > 0.05.
Compare with toothpaste bare substrate group: * P < 0.05, * * P < 0.01, * * * P < 0.001, △ P > 0.05.
experimental result shows, salicin toothpaste sample group and fluocinonide cream group compare with blank group and toothpaste bare substrate group, obviously can suppress white mice auricle acute inflammation swelling caused by dimethylbenzene, show to acute inflammation, to there is obvious antiinflammatory action containing salicin toothpaste sample group.
Adopt toothpaste sample of the present invention to the anti-inflammatory analgesic action (hot plate method) of white mice; Choose body weight 18 ~ 22g healthy Kunming kind ♀ white mice, with GJ-8402 type hot plate dolorimeter, regulable control temperature is at 55 ± 0.5 DEG C, white mice is placed on the pain threshold (white mice contact hot plate is to the time of licking metapedes) hot plate measuring every Mus, allly lick the metapedes time and be less than 5 seconds (S) or be greater than 30 seconds (S) and leaper gives it up, select qualified white mice 40, divide equally 4 groups at random, often organize 10.Blank group, toothpaste bare substrate group, positive drug diclofenac diethylamine emulgel group, Fructus Gardeniae toothpaste sample group.Each group of white mice repeats the normal pain threshold that 2 times measure white mice by the same method, and every minor tick 15min, gets twice normal pain threshold meansigma methods, as the pain threshold before this group white mice administration.Be coated with respectively at the sufficient sole of the foot of the every Mus of each treated animal 4 and only give corresponding tested material 0.2g/, blank group is coated with only gives normal saline 0.2ml/, be coated with 15min, 30min, 45min after giving tested material and measure the pain threshold of white mice by the same method respectively, as still reactionless in white mice 60 seconds (S), white mice is taken out, in order to avoid scald, its pain threshold calculates with 60 seconds (s), record each group of white mice pain threshold, data carry out statistics t inspection, the results are shown in Table 1.
Table 2: containing salicin toothpaste sample to the analgesic activity (hot plate method) of white mice (
± S, n=10)
Note: compare with before administration: * P < 0.05, * * P < 0.01, △ P > 0.05;
Compare with blank group: #P < 0.05, ##P < 0.01, ▲ P > 0.05;
Compare with toothpaste bare substrate group: b P < 0.01
Experimental result shows: containing salicin toothpaste sample group and diclofenac diethylamine emulgel group with before administration and blank group compare, all can significantly improve white mice pain threshold; Compare with toothpaste bare substrate group containing salicin toothpaste sample group, white mice pain threshold can be significantly improved, show, containing salicin toothpaste sample group, there is obvious analgesic activity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, and in following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
Embodiment 1 ~ 5: the application of salicin in toothpaste
Toothpaste constitutive material in embodiment 1 to embodiment 5 and weight percent content are as following table 3:
The preparation method of toothpaste in embodiment 1:
Lotion of toothpaste can adopt the one-step method cream production technology of conventional medicine toothpaste to make: in temporary cylinder, drop into the liquid material such as pure water, sorbitol, salicin measured; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes, drop into essence, close colloid mill, agitator, scraper successively after 10 minutes, vacuum breaker, stop vacuum pump, make after sampling detection is qualified.
The production technology of embodiment 2 to embodiment 5 is with reference to embodiment 1.
Embodiment 6 ~ 10: the application of salicin in collutory
The collutory constitutive material of embodiment 6 to embodiment 10 and weight percent content are as following table 4:
The preparation method of collutory in embodiment 6:
First salicin, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol and is placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirs 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stir 10 minutes, finally add essence and stir 5 minutes, stop stirring, make after sampling detection is qualified.
The production technology of embodiment 7 to embodiment 10 is with reference to embodiment 6.
Embodiment 11 ~ 15: the application of salicin in dentifrice
The dentifrice constitutive material of embodiment 11 to embodiment 15 and weight percent content are as following table 5:
The preparation method of dentifrice in embodiment 11 ~ 15:
Add after the opaque raw materials such as natural whiting, calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium, nipalgin mixed ester sodium are weighed up by formula consumption in mixing agitator to stir and add salicin after 20 minutes and stir 10 minutes; finally add essence, sorbitol stir after 20 minutes shut down, sampling detect qualified after make.
Embodiment 16 ~ 20: the application of salicin in throat lozenge
The throat lozenge constitutive material of embodiment 16 to embodiment 20 and weight percent content are as following table 6:
The preparation technology of embodiment 16 to embodiment 20 adopts existing throat lozenge production technology.
Example 21 ~ 25: the application of gardenia extract in chewing gum:
The chewing gum constitutive material of embodiment 21 to embodiment 25 and weight percent content are as following table 7:
The preparation technology of embodiment 21 to embodiment 25 adopts existing chewing gum production technology.
Claims (6)
1. salicin is preparing the application in oral cavity nursing health products, is namely added in oral cavity nursing health products by the sole active agent of salicin as anti-inflammatory analgesic action in the technique preparing oral cavity nursing health products.
2. salicin according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described salicin is preparing the sole active agent as anti-inflammatory analgesic action in toothpaste technique, the percentage by weight of described salicin in total mastic of toothpaste is 0.11% ~ 5.0%.
3. salicin according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described salicin is preparing the sole active agent as anti-inflammatory analgesic action in collutory technique, the percentage by weight of described salicin in the raw material of collutory is 0.11% ~ 5.0%.
4. salicin according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described salicin is preparing the sole active agent as anti-inflammatory analgesic action in dentifrice technique, the percentage by weight of described salicin in dentifrice raw material is 0.11% ~ 5.0%.
5. salicin according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described salicin is preparing the sole active agent as anti-inflammatory analgesic action in throat lozenge technique, the percentage by weight of described salicin in throat lozenge raw material is 0.11% ~ 5.0%.
6. salicin according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described salicin is preparing the sole active agent as anti-inflammatory analgesic action in chewing gum technique, the percentage by weight of described salicin in chewing-gum material is 0.11% ~ 5.0%.
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| CN201510049072.XA CN104688554A (en) | 2015-01-30 | 2015-01-30 | Application of saligenin in preparation of mouth care healthcare product |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106333956A (en) * | 2016-08-29 | 2017-01-18 | 杨延芳 | Pharmaceutical composition and application thereof in treating acute myelitis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09268117A (en) * | 1996-04-02 | 1997-10-14 | Lion Corp | Composition for oral cavity |
| JP2004189685A (en) * | 2002-12-13 | 2004-07-08 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Functional composition for oral administration |
| CN1761487A (en) * | 2003-03-20 | 2006-04-19 | 法玛西雅公司 | Dispersible formulation of an anti-inflammatory agent |
| US20110028412A1 (en) * | 2009-08-03 | 2011-02-03 | Cappellos, Inc. | Herbal enhanced analgesic formulations |
-
2015
- 2015-01-30 CN CN201510049072.XA patent/CN104688554A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09268117A (en) * | 1996-04-02 | 1997-10-14 | Lion Corp | Composition for oral cavity |
| JP2004189685A (en) * | 2002-12-13 | 2004-07-08 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Functional composition for oral administration |
| CN1761487A (en) * | 2003-03-20 | 2006-04-19 | 法玛西雅公司 | Dispersible formulation of an anti-inflammatory agent |
| US20110028412A1 (en) * | 2009-08-03 | 2011-02-03 | Cappellos, Inc. | Herbal enhanced analgesic formulations |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106333956A (en) * | 2016-08-29 | 2017-01-18 | 杨延芳 | Pharmaceutical composition and application thereof in treating acute myelitis |
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Application publication date: 20150610 |
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