CN104677689A - Suction device, sampling diluting device using suction device, analysis system and sampling analysis method - Google Patents
Suction device, sampling diluting device using suction device, analysis system and sampling analysis method Download PDFInfo
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- CN104677689A CN104677689A CN201410794655.0A CN201410794655A CN104677689A CN 104677689 A CN104677689 A CN 104677689A CN 201410794655 A CN201410794655 A CN 201410794655A CN 104677689 A CN104677689 A CN 104677689A
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Abstract
The invention relates to a suction device. The suction device comprises a suction nozzle and a guide pipe, and a connection part for connecting the suction nozzle and the guide pipe. The suction nozzle is used for collecting a sample. The guide pipe is used for leading out the sample. The central axis of the suction nozzle deviates from the central axis of the whole suction device. The invention further relates to a sampling diluting device using the suction device, an analysis system and a sampling analysis method.
Description
Technical field
The present invention relates to a kind of extractor, use the sampling air mix facilities of this extractor, the analytic system using this extractor and sampling analysis method.
Background technology
When carrying out in-vitro diagnosis experiment, often needing sample, such as: the liquid such as blood, urine, carrying out sampling analysis.The liquid sample mode that current industry is commonly used is for extract liquid by blood taking needle or syringe.But, after adopting this kind of mode also to need to be transferred to by gathered sample and carry out pre-service by specific device in other containers after collecting sample, detect again, thus existing liquid sample mode from the process steps sampling analysis loaded down with trivial details and in the process sample be easily subject to outside contamination.
Summary of the invention
Given this, be necessary simple, the easy to operate extractor of a kind of step to be provided, to use the sampling air mix facilities of this extractor, analytic system and sampling analysis method.
A kind of extractor, comprises suction nozzle and conduit, and connects the connecting portion of described suction nozzle and conduit.Described suction nozzle is used for collecting sample.Described conduit is for deriving sample.The central axis of the whole extractor of center axis deviation of described suction nozzle.
A kind of sampling air mix facilities, it comprise for the extractor of collecting sample and for diluting the dilution tube of collecting sample.Described extractor comprises suction nozzle and conduit, and connects the connecting portion of described suction nozzle and conduit.Described suction nozzle is used for collecting sample.Described conduit is for deriving sample.The central axis of the whole extractor of center axis deviation of described suction nozzle.Described dilution tube is used for splendid attire dilution.The side at the suction nozzle place of described extractor is inserted in dilution tube and is mixed with dilution to be derived by the sample of sampling.Described conduit exposes at dilution tube outer to be poured out by the sample of mixing away from one end of suction nozzle.
A kind of analytic system, the composition of sample for analyzing, it comprises detection medium, analytical equipment, and sampling air mix facilities.Described sampling air mix facilities comprise for the extractor of collecting sample and for diluting the dilution tube of collecting sample.Described extractor comprises suction nozzle and conduit.And connect the connecting portion of described suction nozzle and conduit.Described suction nozzle is used for collecting sample.Described conduit is for deriving sample.The central axis of the whole extractor of center axis deviation of described suction nozzle.Described dilution tube is used for splendid attire dilution.The side at the suction nozzle place of described extractor is inserted in dilution tube and is mixed with dilution to be derived by the sample of sampling.Described conduit exposes at dilution tube outer to be poured out by the sample of mixing away from one end of suction nozzle.Described detection medium is for absorbing the mixed sample poured out from described sampling air mix facilities.Described analytical equipment is for analyzing the composition of sample on described detection medium.
A kind of sampling analysis method, the method comprises the steps:
One sampling air mix facilities is provided, described sampling air mix facilities comprise for the extractor of collecting sample and for diluting the dilution tube of collecting sample, described extractor comprises for the suction nozzle of collecting sample and the conduit for deriving sample, the central axis of the whole extractor of center axis deviation of described suction nozzle, the one end open of described dilution tube and dilution is equipped with in inside;
By the suction nozzle of described extractor and sample contact sample is sucked in described suction nozzle;
Inserted in dilution tube by the suction nozzle drawing sample of extractor, the conduit of described extractor is exposed to the outside of described dilution tube;
Rock insert extractor dilution tube with the sample in suction nozzle is exported in dilution tube with dilution Homogeneous phase mixing;
One detection medium is provided and the sample mixed in dilution tube is exported on described detection medium from the conduit of described extractor;
There is provided an analytical equipment to carry out constituent analysis to the sample on described detection medium.
Relative to prior art, mixed diluting is carried out in extractor of the present invention, the dilution tube that uses the sampling air mix facilities of this extractor, analytic system and sampling analysis method directly to insert after collecting sample dilution is housed, step is simple, and easy to operate and good airproof performance can reduce the outside contamination be subject in collection, diluted sample process.In addition, adopting the suction nozzle of eccentric setting more effectively can be uniformly mixed sample in described extractor makes it mix with dilution and the suction nozzle of eccentric setting more easily stretches into internal tank collection when gathering less sample.
Accompanying drawing explanation
Fig. 1 is the structural representation of the analytic system that embodiment of the present invention provides.
Fig. 2 is the assembling schematic diagram of the sampling air mix facilities in Fig. 1.
Fig. 3 is the decomposing schematic representation of the sampling air mix facilities in Fig. 1.
Fig. 4 is the decomposing schematic representation of the sampling air mix facilities in Fig. 1 along another angle.
Fig. 5 is the cut-open view of sampling air mix facilities in Fig. 1 linearly V-V.
Fig. 6 is the structural representation of another embodiment of sampling air mix facilities in Fig. 5.
Fig. 7 is the structural representation of the lid of sampling air mix facilities in Fig. 1.
Fig. 8 is the method flow diagram of the sampling analysis method that embodiment of the present invention provides.
Main element symbol description
| Analytic system | 1 |
| Sampling air mix facilities | 10 |
| Detect medium | 20 |
| Analytical equipment | 30 |
| Extractor | 12 |
| Dilution tube | 14 |
| Holding section | 140 |
| Resettlement section | 143 |
| Separatrix | 144 |
| Suction nozzle | 120 |
| Conduit | 122 |
| Introduction segment | 1220 |
| Derive section | 1222 |
| Connecting portion | 126 |
| Opening | 1260 |
| Connection rib | 1262 |
| Suction end | 1201 |
| Link | 1202 |
| Cover plate | 1203 |
| Go out vent hole | 1204 |
| Reference column | 124 |
| Abutting end | 1230 |
| Open ports | 1231 |
| Derive end | 1232 |
| Boss | 1233 |
| First reference column | 1240 |
| Second reference column | 1242 |
| Spacer ribs | 1243 |
| Top board | 160 |
| Sidewall | 162 |
| Pickup groove | 163 |
| Fixing rib | 165 |
| Protruding | 164 |
Following embodiment will further illustrate the present invention in conjunction with above-mentioned accompanying drawing.
Embodiment
As shown in Figures 1 to 4, it comprises sampling air mix facilities 10, detects medium 20 and analytical equipment 30 for analytic system 1 that embodiments of the present invention provide.Described sampling air mix facilities 10 comprises extractor 12 and dilution tube 14.Described extractor 12 is for collecting sample, and it comprises suction nozzle 120 and conduit 122 and the connecting portion 126 being connected described suction nozzle 120 and conduit 122.Described suction nozzle 120 is for collecting sample.Described conduit 122 is for deriving sample.The central axis of the whole extractor 12 of center axis deviation of described suction nozzle 120.Described dilution tube 14 is for containing dilution.The side that described extractor 12 inserts suction nozzle 120 place of dilution tube 14 is inserted in dilution tube 14 sample derivation to be mixed with dilution.Described conduit 122 is for deriving mixed sample to described detection medium 20.Described analytical equipment 30 is for analyzing the composition of sample on described detection medium 20.
In the present embodiment, the central axis of described suction nozzle 120 and the central axis of described conduit 122 are parallel to each other and stagger.In other embodiments, the central axis of described suction nozzle 120 not necessarily with the centerline axis parallel of described conduit 122, and can in a predetermined angle.
Described suction nozzle 120 is an elongated hollow tube.Described suction nozzle 120 comprises the suction end 1201 and link 1202 that are oppositely arranged.The suction end 1201 of described suction nozzle 120 is one uncovered for drawing sample, and the suction nozzle 120 that the sample gathered is housed in hollow is inner.The link 1202 of described suction nozzle 120 is sealed by a cover plate 1203.The center of this cover plate 1203 offer one with suction nozzle 120 internal run-through go out vent hole 1204.When drawing sample, described suction end 1201 puts into sample, and described sample to be pressed under capillary action in suction nozzle 120 thus to complete collection.
Described conduit 122 is an elongated hollow tube.Described conduit 122 is included in abutting end 1230 that length direction is oppositely arranged and derives end 1232, and described abutting end 1230 is towards described suction nozzle 120, and described derivation end 1232 is away from described suction nozzle 120.Described abutting end 1230 and derivation end 1232 all offer open ports 1231.See also Fig. 5, described conduit 122 comprises the introduction segment 1220 be connected with abutting end 1230 and the derivation section 1222 be connected with derivation end 1232.Described introduction segment 1220 is extended towards derivation end 1232 by abutting end 1230.Described derivation section 1222 is continued to extend to described derivation end 1232 by the end of described introduction segment 1220 away from abutting end 1230.In the present embodiment, the length of described introduction segment 1220 accounts for the overwhelming majority of whole conduit 122 length, is roughly eighty per cant.The length of described derivation section 1222 only accounts for the sub-fraction of whole conduit 122 length, is roughly twenty percent.The bore of described derivation section 1222 increases towards derivation end 1232 gradually by near one end of abutting end 1230, narrow horn-like of the wide other end in one end.Thus, mixed sample is when oozing from derivation section 1222, and the muddy impurity in sample is more easily trapped on the madial wall of derivation section 1222, thus plays a role in filtering to the sample of deriving.
Described extractor 12 also comprises reference column 124.Described reference column 124 is for offseting to be clamped in dilution tube 14 by conduit 122 with the inwall of dilution tube 14.Described reference column 124 is arranged on the position near described abutting end 1230 away from described derivation end 1232 on conduit 122 outer wall.In the present embodiment, described reference column 124 radially to be extended along conduit 122 by the outer wall of conduit 122 around the central shaft of conduit 122 and forms.The external diameter of described reference column 124 reduces gradually from the one end near a laterally closer abutting end 1230 of deriving end 1232, presents the truncated conical shape that the wide other end in one end is narrow.In the present embodiment, described reference column 124 is the flange around conduit 122 lateral wall one circle.Be understandable that, in other embodiments, described reference column 124 not necessarily needs to arrange around the whole circle of conduit 122, also can only be symmetrical arranged about reference column 124.
The abutting end 1230 of described conduit 122 gives prominence to a predetermined distance to form a boss 1233 from reference column 124 away from the bottom of deriving end 1232.Thus, the boss 1233 that described abutting end 1230 is formed when mixed sample is poured out from dilution tube 14 makes the impurity mixing rear sample can be deposited in the bottom of described reference column 124, thus purifies the mixing sample of deriving.
Described reference column 124 comprises the first reference column 1240, second reference column 1242 and connects the spacer ribs 1243 of described first reference column 1240 and the second reference column 1242.Described first reference column 1240 is arranged near deriving end 1232.Described second reference column 1242 is arranged near abutting end 1230.Described spacer ribs 1243 is extended by the lateral wall of described conduit 122 along the radial direction of conduit 122 and is connected with a side surface of the first reference column 1240 and a side surface of the second reference column 1242 respectively.Described spacer ribs 1243 is arranged around conduit 122 according to the angle intervals preset.Between adjacent spaces rib 1243 formed one be similar to triangular prism shape clearance space 1244 so that extractor 12 shaping after depanning.
Described connecting portion 126 connects the link 1202 of suction nozzle 120 and the abutting end 1230 of conduit 122.Described connecting portion 126 offers opening 1260 to expose the open ports 1231 gone out on vent hole 1204 and abutting end 1230 on described link 1202.In the present embodiment, described connecting portion 126 is a pair connection rib 1262.Wherein one end of described a pair connection rib 1262 is connected to both sides relative on the link 1202 of suction nozzle 120 respectively.The other end of described a pair connection rib 1262 is connected to the relative both sides of the abutting end 1230 of described conduit 122 and described reference column 124 respectively near the bottom of abutting end 1230.Described conduit 122 is not directly connected with suction nozzle 120.The central shaft of described conduit 122 and the central shaft of described suction nozzle 120 are parallel to each other and stagger, and namely the central shaft of described conduit 122 is not aimed at mutually with the central shaft of described suction nozzle 120.In the present embodiment, described conduit 122 is positioned at the center of whole reference column 124, then described suction nozzle 120 is relative to the edge of conduit 122 closer to described reference column 124.So the container of tiltable carrying sample makes sample suction nozzle 120 that reference column 124 edge arranges is easier stretches into collecting sample in container along container side wall to being now partial to close to the position of vessel port along the wall flow of container when sample is less.And the suction nozzle 120 of eccentric setting when rocking dilution tube 14 can more effectively agitation and dilution liquid and sample to make it mix more even.
Described dilution tube 14 is the elongated hollow cylinder of one end open.The sidewall of described dilution tube 14 comprises holding section 140 and resettlement section 143.Described holding section 140 is one section of sidewall that dilution tube 14 is positioned at opening part.Described resettlement section 143 is one section of sidewall bottom bottom, holding section 140 to dilution tube 14.With the reference column 124 on extractor 12, described holding section 140 is for coordinating that described extractor 12 is clamped on dilution tube 14.The bore of described holding section 140 is reduced towards bottom gradually by openend, narrow round table-like of wide opposite side in side.The bore of described resettlement section 143 can remain unchanged, also can be reduced gradually bottom dilution tube 14 by bottom, fastening end 140, the bore change of right resettlement section 143 changes slowly compared with the bore of holding section 140 thus forms a separatrix 144 in holding section 140 and the junction of resettlement section 143.The opening periphery of described dilution tube 14 extends outward a circle edge 142.The maximum outside diameter that the opening diameter of described dilution tube 14 is greater than described reference column 124 can insert in dilution tube 14 completely to make suction nozzle 120 one end of described extractor 12.When described suction nozzle 120 stretches into bottom dilution tube 14, along with holding section 140 internal diameter diminishes gradually, with the fixing position of suction nozzle 120 in dilution tube 14 on the inwall that the reference column 124 of described suction nozzle 120 is clamped on dilution tube 14, to insert in dilution tube 14 at the extractor 12 having drawn sample and the sample in suction nozzle 120 can be derived by dandle dilution tube 14 after fixing and mix with the dilution liquid phase in dilution tube 14.
Be understandable that, described extractor 12 can be set by the change of the internal diameter of the external diameter and described dilution tube 14 that adjust described reference column 124 and insert the degree of depth in dilution tube 14.Preferably, as shown in Figure 5, in the present embodiment, the inwall that described extractor 12 is stuck in dilution tube 14 by the second reference column 1242 is fixed.In other embodiments, as shown in Figure 6, the inwall that described extractor 12 can also be stuck in dilution tube 14 by the first reference column 1240 is fixed.
As shown in Figure 5 and 7, described sampling air mix facilities 1 also comprises lid 16.Described lid 16 is enclosed within the openend of described dilution tube 14 to cover the derivation end 1232 of the conduit 122 exposed by the openend of dilution tube 14.Described lid 16 is the cylinder of one end open, it sidewall 162 comprising top board 160 and extended one week towards the same side by described top board 160 periphery and formed.Described top board 160 surrounds a receiving space for covering the derivation end 1232 of described conduit 122 with sidewall 162.Described top board 160 center be positioned on the surface, side of receiving space is provided with a pickup groove 163.The inwall of described pickup groove 163 extends multiple fixing rib 165 towards the center of top board 160 to clamp the derivation end 1232 of described conduit 122 when lid is enclosed within dilution tube 14.The outwardly formation one in center projection 164 bottom described pickup groove 163.When the derivation that described lid 16 covers described conduit 122 holds 1232, described protruding 164 fill in the opening parts of deriving end 1232 prevents the mixing sample in dilution tube 14 from overflowing better.
Described extractor 12, dilution tube 14 and lid 16 are medical disposable material, all or are partly made up of transparent plastic material.Preferably, in the present embodiment, described extractor 12 is made up of polystyrene (Polystyrene, PS), and described dilution tube 14 and lid 16 are made up of polypropylene (Polypropylene, PP).Described dilution tube 14 and lid 16 have elasticity, so that squeeze out mixed sample and keep comfortable hand sense of touch.
Described detection medium 20 is analyzed to be transferred to analytical equipment 30 for absorbing mixed sample.Can comprise in described detection medium 20 and specifically detect reagent, to carry out chemical reaction with mixed sample thus to detect ready for follow-up analysis.In the present embodiment, described detection medium is test paper, and in described dilution tube 14, mixed sample is via open ports 1231 inflow catheter 122 on the abutting end 1230 of conduit 122, and is derived by the derivation end 1232 of conduit 122 and be dropped on described test paper.Described lid 16 is pulled out when deriving sample.
Described analytical equipment 30 carries out constituent analysis to the sample detected on medium 20, to obtain the parameter of special component in sample, and the content etc. of such as this special component.In the present embodiment, described sample is blood.Be understandable that, in other embodiments, described sample can also be the liquid such as urine or saliva.
Directly insert after described analytic system 1 adopts extractor 12 collecting sample in the dilution tube 14 that dilution is housed and carry out mixed diluting and can shift easily, and can also carry out sealing reducing by cover upper cover body 16 chance that sample reveals in mixing and transfer process also prevent introduced contaminants to the pollution of sample simultaneously after extractor 12 inserts dilution tube 14.
As shown in Figure 8, Fig. 8 is a kind of method flow diagram using above-mentioned analytic system 1 pair of sample to carry out sampling analysis provided by the present invention, and this sampling analysis method comprises the steps:
Step S801, provides a sampling air mix facilities 10.Described sampling air mix facilities 10 comprise for the extractor 12 of collecting sample and for diluting the dilution tube 14 of collecting sample.Described extractor 12 comprises for the suction nozzle 120 of collecting sample and the conduit 122 for deriving sample.The central axis of the whole extractor 12 of center axis deviation of described suction nozzle 120.Described dilution tube 14 one end open and dilution is equipped with in inside.
Step S802, by the suction nozzle 120 of described extractor 12 with sample contact sample is sucked in described suction nozzle 120.
Step S803, the suction nozzle 120 extractor 12 having been drawn sample inserts in dilution tube 14.The conduit 122 of described extractor 12 is exposed to the outside of described dilution tube 14.
Step S804, rock the dilution tube 14 that inserts extractor 12 with by suction nozzle sample export in dilution tube 14 with dilution Homogeneous phase mixing.Described sampling air mix facilities 10 also comprises a lid 16.Described lid 16 is enclosed within the openend of described dilution tube 14 before rocking to cover the conduit 122 exposed by the openend of dilution tube 14.
Step S805, one detection medium 20 is provided, unplug lid 16, and dilution tube 14 is put upside down make conduit 122 derivation end 1232 down, then in dilution tube 14, mixed sample, via open ports 1231 inflow catheter 122 on the abutting end 1230 of conduit 122, and to be exported on described detection medium 20 by the derivation end 1232 of conduit 122.Can comprise in described detection medium 20 and specifically detect reagent, to carry out chemical reaction with mixed sample thus to detect ready for follow-up analysis.
Step S806, provides an analytical equipment 30 to carry out constituent analysis to the sample on described detection medium 20.
Although the present invention discloses as above with embodiment; so itself and be not used to limit the present invention; have in any art and usually know the knowledgeable; without departing from the spirit and scope of the invention; when doing a little change and retouching, thus the protection domain of the present invention when depending on after the attached claim person of defining be as the criterion.
Claims (14)
1. an extractor, comprises suction nozzle and conduit, and connects the connecting portion of described suction nozzle and conduit, described suction nozzle be used for collecting sample, described conduit for deriving sample, the central axis of the whole extractor of center axis deviation of described suction nozzle.
2. extractor as claimed in claim 1, it is characterized in that: described conduit and described suction nozzle are separated from each other, the both ends open of described suction nozzle, the both ends open of described conduit, described connecting portion is provided with opening to expose described suction nozzle and conduit one end open separately, the central axis of described conduit and the central axes of whole extractor.
3. extractor as claimed in claim 2, it is characterized in that: also comprise reference column, described reference column radially extends from the outer wall of described conduit and is formed, described conduit comprises near the abutting end of described suction nozzle and the derivation end away from described suction nozzle, described abutting end pass described reference column and an outstanding predetermined distance to form a boss.
4. extractor as claimed in claim 3, is characterized in that: the external diameter of described reference column reduces gradually from the side of the abutting end of a laterally closer described conduit of the derivation end near described conduit.
5. extractor as claimed in claim 3, it is characterized in that: described connecting portion comprises a pair connection rib, wherein one end of described connection rib is connected to the relative both sides of one end of described suction nozzle respectively, the other end of described connection rib is connected to the relative both sides of the abutting end of described conduit and described reference column respectively near the bottom of described abutting end, and described opening is between described connection rib.
6. a sampling air mix facilities, it comprise for the extractor of collecting sample and for diluting the dilution tube of collecting sample, described extractor comprises suction nozzle and conduit, and connect the connecting portion of described suction nozzle and conduit, described suction nozzle is used for collecting sample, described conduit is for deriving sample, the central axis of the whole extractor of center axis deviation of described suction nozzle, described dilution tube is used for containing dilution, the side at the suction nozzle place of described extractor is inserted in dilution tube and is mixed with dilution to be derived by the sample of sampling, described conduit exposes at dilution tube outer to be poured out by the sample of mixing away from one end of suction nozzle.
7. to sample as claimed in claim 6 air mix facilities, it is characterized in that: described conduit and described suction nozzle are separated from each other, the both ends open of described suction nozzle, the both ends open of described conduit, described connecting portion is provided with opening to expose described suction nozzle and conduit one end open separately, the central axis of described conduit and the central axes of whole extractor.
8. to sample as claimed in claim 7 air mix facilities, it is characterized in that: also comprise reference column, described reference column radially extends from the outer wall of described conduit and is formed, described conduit comprises near the abutting end of described suction nozzle and the derivation end away from described suction nozzle, described abutting end pass described reference column and an outstanding predetermined distance to form a boss.
9. to sample as claimed in claim 8 air mix facilities, it is characterized in that: the external diameter of described reference column reduces gradually from the side of the abutting end of a laterally closer described conduit of the derivation end near described conduit.
10. to sample as claimed in claim 8 air mix facilities, it is characterized in that: described connecting portion comprises a pair connection rib, wherein one end of described connection rib is connected to the relative both sides of one end of described suction nozzle respectively, the other end of described connection rib is connected to the relative both sides of the abutting end of described conduit and described reference column respectively near the bottom of described abutting end, and described opening is between described connection rib.
11. sample air mix facilities as claimed in claim 8, and it is characterized in that: described sampling air mix facilities also comprises lid, described lid is enclosed within described dilution tube to cover the derivation end of described conduit.
12. sample air mix facilities as claimed in claim 11, it is characterized in that: the place of bottom centre of described lid is provided with a pickup groove, the inwall of described pickup groove extends multiple fixing rib to clamp the derivation end of described conduit when lid is enclosed within dilution tube towards the center of top board, and the center bottom described pickup groove forms one for sealing the projection of described conduit.
13. 1 kinds of analytic systems, the composition of collecting sample for analyzing, it comprises detection medium, analytical equipment, and as the sampling air mix facilities of any one in claim 6-12 item, described detection medium is for absorbing the mixed sample poured out from described sampling air mix facilities, and described analytical equipment is for analyzing the composition of sample on described detection medium.
14. 1 kinds of sampling analysis methods, the method comprises the steps:
One sampling air mix facilities is provided, described sampling air mix facilities comprise for the extractor of collecting sample and for diluting the dilution tube of collecting sample, described extractor comprises for the suction nozzle of collecting sample and the conduit for deriving sample, the central axis of the whole extractor of center axis deviation of described suction nozzle, the one end open of described dilution tube and dilution is equipped with in inside;
By the suction nozzle of described extractor and sample contact sample is sucked in described suction nozzle;
Inserted in dilution tube by the suction nozzle drawing sample of extractor, the conduit of described extractor is exposed to the outside of described dilution tube;
Rock insert extractor dilution tube with the sample gathered in suction nozzle is exported in dilution tube with dilution Homogeneous phase mixing;
One detection medium is provided and the sample mixed in dilution tube is exported on described detection medium from the conduit of described extractor;
There is provided an analytical equipment to carry out constituent analysis to the sample on described detection medium.
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| CN113564026A (en) * | 2021-06-30 | 2021-10-29 | 佛山丁智生物科技有限公司 | Micro-droplet sample introduction mechanism, device and method |
| CN113564026B (en) * | 2021-06-30 | 2024-04-26 | 佛山丁智生物科技有限公司 | Droplet sampling mechanism, device and method |
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