CN104675808B - A kind of optical fiber microfluid drive and driving method - Google Patents
A kind of optical fiber microfluid drive and driving method Download PDFInfo
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- CN104675808B CN104675808B CN201510102507.2A CN201510102507A CN104675808B CN 104675808 B CN104675808 B CN 104675808B CN 201510102507 A CN201510102507 A CN 201510102507A CN 104675808 B CN104675808 B CN 104675808B
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- 239000000835 fiber Substances 0.000 claims description 24
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Abstract
The invention belongs to microfluidic control field, more particularly to a kind of optical fiber microfluid drive and driving method.Optical fiber microfluid drive, including mini flume 1, quartzy micro-pipe 2, microfluid 3, optical fiber 4, light source 5, absorption fluid 6, optical fiber in quartzy micro-pipe insertion mini flume with being placed in mini flume both sides, the light sent from light source causes the absorption fluid in groove to produce thermal convection current campaign in being incident on mini flume by optical fiber, thermal convection current campaign produces negative pressure at the quartzy micro-pipe mouth of pipe, the microfluid in quartzy micro-pipe is produced the flowing into mini flume.The present invention use quartzy micro-pipe as microfluidic channel, and the structural parameters of quartzy micro-pipe can be drawn such as the method for drawing optical fiber, can flexibly control size, the structure of microfluidic channel, and technology maturation, make simply, cost it is low.
Description
Technical field
The invention belongs to microfluidic control field, more particularly to a kind of optical fiber microfluid drive and driving method.
Background technology
Microfluidic control technology refers to control at least one-dimensional low-dimensional channel design for micron or even nanoscale
Volume be picoliters to nanoliter fluid flow and mass transfer, the technology of heat transfer, can be widely applied to biochemical analysis, immune point
The various fields such as analysis, micro-wound surgical operation, environmental monitoring.
The key technology of microfluidic control mainly includes：The design of MCA and manufacture, the drive of micro/nano-scale fluid
The dynamic integrated and encapsulation with control and microfluid control device and system.And the design of MCA and manufacture and micro/nano-scale
The driving of fluid and the premise that control is microfluidic control.
Fluid needs to be flowed in some way in the microchannel of certain size and structure in microfluidic system, with
The purpose of heat transfer, mass transfer and MOMENTUM TRANSMISSION is reached, is the core of microfluidic system.Microchannel is processed on silicon and glass material
It is main to use photoetching and lithographic technique, but photoetching process is harsh to substrate surface quality requirement, complex process is, it is necessary to the exposure of costliness
Light and etching apparatus, cost is higher, the more low deficiency of yield rate.The processing of polymer-based material generally using soft lithography come
Complete, but organic matter poor thermal conductivity, non-refractory, processing technology and micro manufacturing technique are incompatible, make it in microflow control technique
Using by a definite limitation.
In addition, the resistance that fluid flows in the passage of micro/nano-scale is very big, to form effective driving can have a variety of
Method, such as carries out pressure-driven, or utilize EOF, electrophoresis, electrowetting and Jie using syringe pump, air pump, wriggling Micropump
The phenomenons such as electrofluid realize that electric power drives.Which kind of type of drive it will consider that microfluid flow is atomic, flow velocity is controllable, low using
Cost and longevity of service.
At present, the driving of microfluid and control technology species are a lot, such as divide by principle, can be divided into pressure-driven, electric water
Power driving, driven by electroosmosis, thermal drivers, surface tension driving, centrifugal force driving etc..Pressure-driven mode is that micro-fluidic chip is most normal
The type of drive seen, is motion of the fluid under barometric gradient effect.Pressure is belonged to using syringe pump, air pump, wriggling Micropump etc.
Power drives.Nakamura H et al. article " Preparation of CdSe nanocrystals in a micro-flow-
The microfluidic control for the injection pump type mentioned in reactor ", microfluid is quickly accurately controlled using microsyringe by temperature
Injection, it is possible to achieve the control of molecule, and may be reused, this article is published in Chemical
Communications,2002(23):On 2844-2845；Green pearl of other Taiwan Province Industrial Technology Research Institute Wu etc.
Patent " micro fluid dynamcis and speed control unit and method " (application number of application：CN200510135579.3) it is also a kind of work
Plug is pressure-driven method.This piston-type pressure driving method using outer piston due to controlling microfluid, complicated, behaviour
Make difficult, integrated difficulty is high；Grover W H et al. article " Monolithic membrane valves and
diaphragm pumps for practical large-scale integration into glass microfluidic
Devices " and Xie J et al. article " Surface micromachined electrostatically actuated
Membrane pump is described in micro peristaltic pump " respectively and peristaltic pump produces method of the pressure to drive microfluid
(Sensors and Actuators B are published in respectively:Chemical,2003,89(3):315-323 and Lab on a
Chip,2004,4(5):On 495-501), in addition there are a variety of pressure-driven methods using mechanical pump as power, he
It is inevitable it is more or less to introduce mechanical structure or tiny device, this is unfavorable for micro-fluidic chip.Therefore we
Propose a kind of new pressure-driven method --- negative pressure driving method, this method is simple in construction, pressure controlling section with it is micro-
Fluidic chip separation is contactless, it is easy to accomplish miniaturization, integrated.
In summary technology, we make a kind of quartzy micro-pipe by the use of method for drawing optical fibers and are used as microfluidic channel, utilize
Photic fuel factor make liquid produce thermal convection current, by the use of thermal convection current at the quartzy micro-pipe mouth of pipe Bernoulli effect produce negative pressure as
Driving, it is proposed that a kind of new microfluid drive and driving method.
The content of the invention
It is an object of the invention to provide a kind of based on the compact easy to operate optical fiber microfluid drive of optical fiber structure,
The present invention also aims to provide a kind of optical fiber microfluid drive driving method.
The object of the present invention is achieved like this：
Optical fiber microfluid drive, including mini flume 1, quartzy micro-pipe 2, microfluid 3, optical fiber 4, light source 5, absorption stream
Body 6, optical fiber in quartzy micro-pipe insertion mini flume with being placed in mini flume both sides, and the light sent from light source is incident by optical fiber
The absorption fluid in groove is caused to produce thermal convection current campaign in mini flume, thermal convection current campaign produces negative at the quartzy micro-pipe mouth of pipe
Pressure, makes the microfluid in quartzy micro-pipe produce the flowing into mini flume.
Optical fiber is single-mode fiber, multimode fibre or photonic crystal fiber, and fiber end face is planar end surface, hemispherical end face, throwing
The linear end face of thing or tapered end face.
Light source outgoing optical wavelength is corresponding with the absworption peak wavelength that fluid is absorbed in mini flume or is inhaled comprising multiple
Receive peak.
Optical fiber is with being placed in mini flume both sides in quartzy micro-pipe insertion mini flume or having an angle.
Optical fiber micro fluid dynamcis method, the optical fiber of described optical fiber microfluid drive and quartzy micro-pipe insertion is miniature
In tank, the light sent from light source causes the absorption fluid in groove to produce thermal convection current in being incident on mini flume by optical fiber transmission
Motion, thermal convection current campaign produces negative pressure at the quartzy micro-pipe mouth of pipe, the microfluid in quartzy micro-pipe is flowed into mini flume,
By adjusting the microfluid rate of outflow in the quartzy micro-pipe of the big minor adjustment of light source power.
The beneficial effects of the present invention are：
The present invention uses quartzy micro-pipe as microfluidic channel, and the structural parameters of quartzy micro-pipe can be such as the side of drawing optical fiber
Method is drawn, and can flexibly control size, the structure of microfluidic channel, and technology maturation, to make simple, cost low.It is of the invention skilful
The liquid convection that the fuel factor of the photic liquid of wonderful utilization is produced, produces negative pressure dynamic as pressure-driven in microfluidic channel mouthful
Power, it is to avoid microfluid is directly contacted with pressue device.Transmitted using optical fiber as light energy, transimission power is high, structure is small
Ingeniously, the integration and miniaturization of device is conducive to.Can according to the power of the big minor adjustment fiber exit light of light source power so that
The convection velocity in liquid is adjusted, the pressure size of regulation microfluidic channel mouthful realizes the flowing speed of high accuracy regulation microfluid
Degree.
Brief description of the drawings
Fig. 1 places stereogram for the quartzy micro-pipe of the present invention with fiber-coaxial.
Fig. 2 places side view for the quartzy micro-pipe of the present invention with fiber-coaxial.
Fig. 3 has an angle top view for the quartzy micro-pipe of the present invention with optical fiber.
Fig. 4 is the present invention quartzy micro-tubular structure schematic diagram used.
Embodiment
It is described further with reference to embodiments with the accompanying drawing present invention, but the protection model of the present invention should not be limited with this
Enclose.
The present invention utilizes photic fuel factor, and the light that light source is sent transmits outgoing in a liquid by optical fiber, produces photic heat
Effect so that liquid flows, negative pressure is formed in quartzy micro-pipe mouthful, realizes that microfluid flows out.
Optical fiber microfluid drive, including mini flume 1, quartzy micro-pipe 2, microfluid 3, optical fiber 4, light source 5, absorption stream
Body 6；It is characterized in that：Optical fiber 4 in the quartzy insertion of micro-pipe 2 mini flume 1 with being placed in the both sides of mini flume 1, and end face is at a distance of conjunction
Suitable distance, the light sent from light source 5 is incident on by optical fiber 4 causes the absorption fluid 6 in groove to produce thermal convection current in mini flume 1
Motion, thermal convection current campaign produces negative pressure at the quartzy mouth of pipe of micro-pipe 2, the microfluid 3 in quartzy micro-pipe 2 is produced to mini flume
Flowing in 1.
A kind of described optical fiber microfluid drive, it is characterised in that：Described optical fiber 4 can be single-mode fiber, many
Mode fiber or photonic crystal fiber, the end face of optical fiber 4 can be planar end surface, hemispherical end face, parabola shaped end face or tapered end face.
A kind of described optical fiber microfluid drive, it is characterised in that：The described outgoing optical wavelength of light source 5 should with it is miniature
An absworption peak wavelength of absorption fluid 6 is corresponding in tank 1 or includes multiple absworption peaks.
A kind of described optical fiber microfluid drive, it is characterised in that：Described optical fiber 4 is embedded in micro- with quartzy micro-pipe 2
The both sides of mini flume 1 are placed in type tank 1 or have an angle.
A kind of optical fiber micro fluid dynamcis method, the optical fiber 4 of optical fiber microfluid drive and quartzy micro-pipe 2 is embedded in miniature
In tank 1, end face is at a distance of suitable distance, and the light sent from light source 5 is incident in mini flume 1 by the transmission of optical fiber 4 causes groove
In absorption fluid 6 produce thermal convection current campaign, thermal convection current campaign produces negative pressure at the quartzy mouth of pipe of micro-pipe 2, makes in quartzy micro-pipe 2
Microfluid 3 flowed into mini flume 1, flow out speed by adjusting microfluid 3 in the quartzy micro-pipe 2 of the watt level of light source 5 regulation
Degree.
Operation principle：
Absorbed because material is selective to light, any liquid can all have the absorption spectrum of oneself corresponding light,
Heat is converted into after the energy of light is by liquid absorption.Fiber exit illumination is mapped in liquid, is deposited because light distribution is uneven
In action of thermal difference, the high liquid of temperature rises, and the low liquid of temperature supplements rapidly reheatings, thus be formed about in light field it is hot right
Stream.It is fast specific to quartzy micro-pipe mouth of pipe liquid flow velocity in the present invention, understood to form negative pressure in the mouth of pipe by Bernoulli effect,
Realize the microfluid outflow in quartzy micro-pipe.
The present invention can be realized by such a way：As shown in Figure 1.
In the sustained height perforate of a mini flume 1, quartzy micro-pipe 2 and optical fiber 4 are passed through from hole respectively and cause stone
English micro-pipe 2 and optical fiber 4 are inoculated with microfluid 2 apart from suitable and then be fixed with epoxy resin inside quartzy micro-pipe 2, optical fiber 4 with
Light source 5 is connected, and is irrigated in mini flume 1 to the absorbent liquid 6 of the wavelength of light source 5, is allowed to liquid level and is higher than the quartzy He of micro-pipe 2
The height of optical fiber 4；
When light is transferred in absorbability liquid 6 by light source 5 by optical fiber 4, the absorption heat production due to liquid 6 to light wave,
The high liquid flows upwards of temperature for liquid 6, the low liquid of temperature supplements rapidly reheating, convection current is formed, in quartz
Because Bernoulli effect occurs for the flowing of liquid at the mouth of pipe of micro-pipe 2, the microfluid 3 produced in negative pressure, quartzy micro-pipe 2 outflows, real
The flowing velocity of microfluid 3 can be controlled by showing the driving of optical fiber microfluid, and adjusting the watt level of light source 5.
Embodiment one：The making of optical fiber microfluid drive.Step is as follows：
1st, the upper opening of mini flume of long 25mm, wide 5mm, high 10mm 1 one is taken first, takes 125 μm of external diameter, internal diameter 20
μm, long 0.5m 2 one sections of quartzy micro-pipe, take length 1m 4 one sections of common standard single-mode fiber, take with FC interfaces can Power Regulation
Rate 1480nm LASER Light Sources 5 one.
2nd, open the aperture of an a diameter of 0.5mm respectively in the high 4mm positional symmetries in the both sides of mini flume 1 taken, will be taken
The two ends of quartzy micro-pipe 2 cut with optical fiber cutter smooth, the coat of the one end of common standard single-mode fiber 4 taken is shelled
From 20~30mm smooth and remaining naked fibre length about 10mm is cut using optical fiber cutter.By the quartzy micro-pipe 2 handled well and naked
Optical fiber 4 penetrates inside from the two ends aperture of mini flume 1 respectively, makes quartzy micro-pipe 2 and the both ends of the surface of bare fibre 4 at a distance of about 300 μ
M is simultaneously coaxial, and quartzy micro-pipe 2 and bare fibre 4 are fixed on to the two ends of mini flume 1 respectively using epoxy resin.
3rd, 20~30mm coats, profit are peeled off in one end that the common standard single-mode fiber 4 of the side of mini flume 1 will be fixed on
Make remaining naked fibre length 12mm, insertion fiber active linker and 1480nm LASER Light Source phases with optical fiber cutter cutting is smooth
Even, so that the optical fiber microfluid drive that completed.
Embodiment two：A kind of micro fluid dynamcis is realized using optical fiber microfluid drive, as shown in Figure 1.
1st, such as step of embodiment one is made after optical fiber microfluid drive, is poured into mini flume 1 to 1480nm
The larger distilled water 6 of optical band absorbability, untill liquid level reaches 8~9mm positions, now due to quartzy micro-pipe 2
Distilled water 6 is full of in capillarity, quartzy micro-pipe 2.
2nd, the other end for the quartzy micro-pipe 2 handled well is placed in the rhodamine B solution pool of microfluid 3, it is former according to linker
The Luo Dan of microfluid 3 in the height in reason regulation microfluid pond so that the liquid pressure balance in quartzy micro-pipe 2, i.e., quartzy micro-pipe 2
Bright B solution is in stable state.
3rd, the power of regulation 1480nm LASER Light Sources 5 is allowed to minimum, opens in 1480nm LASER Light Sources 5, observation mini flume 1
The flowing of water, the miniflow passed through due to the flowing of the reclaimed water of mini flume 1 in the mouth of pipe formation negative pressure of quartzy micro-pipe 2, quartzy micro-pipe 2
The rhodamine B solution of body 3 is flowed outwardly, and the size of the power of regulation 1480nm LASER Light Sources 5 can change the Luo Wei in quartzy micro-pipe 2
The speed that the red bright B solution of fluid 3 is flowed outwardly.So far we are realized to the rhodamine B solution of microfluid 3 in quartzy micro-pipe 2
Micro fluid dynamcis.
Claims (5)
1. a kind of optical fiber microfluid drive, including mini flume (1), quartzy micro-pipe (2), microfluid (3), optical fiber (4), light
Source (5), absorption fluid (6), it is characterised in that：Optical fiber is embedded in mini flume with quartzy micro-pipe and is placed in mini flume both sides,
The light sent from light source causes the absorption fluid in groove to produce thermal convection current campaign, thermal convection current in being incident on mini flume by optical fiber
Motion produces negative pressure at the quartzy micro-pipe mouth of pipe, the microfluid in quartzy micro-pipe is produced the flowing into mini flume.
2. a kind of optical fiber microfluid drive according to claim 1, it is characterised in that：Described optical fiber is single-mode optics
Fine, multimode fibre or photonic crystal fiber, fiber end face is planar end surface, hemispherical end face, parabola shaped end face or tapered end face.
3. a kind of optical fiber microfluid drive according to claim 1, it is characterised in that：Described light source outgoing light wave
A long absworption peak wavelength with absorbing fluid in mini flume is corresponding or includes multiple absworption peaks.
4. a kind of optical fiber microfluid drive according to claim 1, it is characterised in that：Described optical fiber and quartz are micro-
Mini flume both sides are placed in pipe insertion mini flume or have an angle.
5. a kind of optical fiber micro fluid dynamcis method, it is characterised in that：By the optical fiber of optical fiber microfluid drive and quartzy micro-pipe
In embedded mini flume, the light sent from light source causes the absorption fluid production in groove in being incident on mini flume by optical fiber transmission
Heat convective motion, thermal convection current campaign produces negative pressure at the quartzy micro-pipe mouth of pipe, makes microfluid in quartzy micro-pipe to Miniature water
Flowed in groove, by adjusting the microfluid rate of outflow in the quartzy micro-pipe of the big minor adjustment of light source power；Optical fiber microfluid drive,
Including mini flume (1), quartzy micro-pipe (2), microfluid (3), optical fiber (4), light source (5), absorption fluid (6), optical fiber and quartz
Mini flume both sides are placed in micro-pipe insertion mini flume, the light sent from light source makes in being incident on mini flume by optical fiber
The absorption fluid obtained in groove produces thermal convection current campaign, and thermal convection current campaign produces negative pressure at the quartzy micro-pipe mouth of pipe, makes quartzy micro-pipe
In microfluid produce the flowing into mini flume；Described optical fiber is single-mode fiber, multimode fibre or photonic crystal fiber,
Fiber end face is planar end surface, hemispherical end face, parabola shaped end face or tapered end face；Described light source outgoing optical wavelength with it is miniature
An absworption peak wavelength of absorption fluid is corresponding in tank or includes multiple absworption peaks；Described optical fiber is embedded in quartzy micro-pipe
Mini flume both sides are placed in mini flume or have an angle.
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| CN106582903B (en) * | 2016-12-26 | 2018-12-07 | 华南师范大学 | Micro-fluidic chip and its microfluidic methods based on photo-thermal waveguide |
| CN111617683B (en) * | 2020-04-10 | 2022-04-19 | 桂林电子科技大学 | Photothermal microfluidic mixer based on porous optical fiber |
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| CN1991370A (en) * | 2005-12-29 | 2007-07-04 | 财团法人工业技术研究院 | Micro-fluid drive and speed control device and method |
| CN101561448A (en) * | 2008-04-18 | 2009-10-21 | 中国科学院大连化学物理研究所 | Negative-pressure pinched injection method of micro-fluidic chip based on integrated minipump valve and special chip thereof |
| CN101609088A (en) * | 2008-06-16 | 2009-12-23 | 索尼株式会社 | Flow sending method in micro-fluidic chip and the micro-fluidic chip |
| CN103920545A (en) * | 2014-04-24 | 2014-07-16 | 上海市刑事科学技术研究院 | Microfluid tunable optical filter based on PDMS (Polydimethylsiloxane) chip and manufacture method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7270786B2 (en) * | 2001-03-28 | 2007-09-18 | Handylab, Inc. | Methods and systems for processing microfluidic samples of particle containing fluids |
| WO2009102796A1 (en) * | 2008-02-11 | 2009-08-20 | Integrated Sensing Systems, Inc. | Microfluidic device and methods of operation and making |
| KR101578149B1 (en) * | 2009-01-29 | 2015-12-17 | 삼성전자주식회사 | Microfluidic valve unit for controlling fluid flow and method for fabricating the same |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1991370A (en) * | 2005-12-29 | 2007-07-04 | 财团法人工业技术研究院 | Micro-fluid drive and speed control device and method |
| CN101561448A (en) * | 2008-04-18 | 2009-10-21 | 中国科学院大连化学物理研究所 | Negative-pressure pinched injection method of micro-fluidic chip based on integrated minipump valve and special chip thereof |
| CN101609088A (en) * | 2008-06-16 | 2009-12-23 | 索尼株式会社 | Flow sending method in micro-fluidic chip and the micro-fluidic chip |
| CN103920545A (en) * | 2014-04-24 | 2014-07-16 | 上海市刑事科学技术研究院 | Microfluid tunable optical filter based on PDMS (Polydimethylsiloxane) chip and manufacture method thereof |
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