CN104666658A - Traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia, and preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia, and preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 10-15 parts of codonopsis pilosula, 10-15 parts of poria, 15-20 parts of raw rhizoma atractylodis macrocephalae, 15-30 parts of radix rehmanniae preparata, 10-15 parts of eucommia ulmoides, 15-20 parts of glossy privet fruit, 15-30 parts of salviae miltiorrhizae, 10-12 parts of olibanum, 10-15 parts of cattail pollen, 10-15 parts of trogopterus dung, 8-10 parts of eupolyphaga, 15-30 parts of white paeony root, 15-30 parts of rhizoma corydalis and 5-15 parts of honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, is free of a toxic or side effect, convenient to process, low in cost, and obvious in treatment effect on osteosarcoma ostalgia and bone metastasis neoplasm. The invention further discloses a preparation method of the traditional Chinese medicine composition and a medicine prepared from the traditional Chinese medicine composition for treating osteosarcoma ostalgia and bone metastasis neoplasm ostalgia.
Description
Technical field
The invention belongs to modern Chinese traditional medicine field, relate to a kind of treat osteosarcoma osteodynia and metastatic tumor of bone osteodynia Chinese prescription and application in the medicine of preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia.
Background technology
Osteosarcoma is one of common malignant tumor of teenager, and send out well the age between 3-25 year, the multiple long bone being born in human body, sees femur at most.Osteosarcomatous main clinical manifestation is: local pain and swelling, and pain is persistence severe pain, is difficult to stand, bone and arthralgia or swelling, and night increases the weight of, and whole body is with heating, weight loss, fatigue and mobility decline simultaneously.Disease progression is rapid, and grade malignancy is high, often Lung metastases occurs in early days and occurs the symptoms such as cough, spitting of blood.
Metastatic tumor of bone refers to other organs tumor, is transferred to the tumor of osseous tissue by the multiple channel such as blood or lymph.The modal primary tumo(u)r of metastatic tumor of bone is breast carcinoma, pulmonary carcinoma, thyroid carcinoma and renal carcinoma, and other have nasopharyngeal carcinoma, cervical cancer, gastric cancer, colon cancer, ovarian cancer, the esophageal carcinoma, melanoma and lymphoma etc.All can there is metastatic tumor in the bone of whole body, but common with rib, vertebrae, ilium, pubis, humerus, femur and skull etc. clinically.The modal symptom of metastatic tumor of bone is local pain.Also can there is pathologisch Bruch and subside or the outer extensive diffusive of bone and cause the neurological symptom caused by corresponding spinal cord, cranial nerve and peripheral nerve pressurized due to osteoclasia.
The symptom that metastatic tumor of bone and osteosarcoma also have some identical.Bone tumor and pernicious metastatic tumor of bone develop very fast because of it, often merge General Symptoms, and as weak, anemia, malnutrition, even cachexia, visible local pain and tenderness, normal and lump occurs simultaneously or first occurs.Start pain slightly in intermittent dull pain, then become persistence and to give a farfetched interpretation sample severe pain, make us unbearably, especially to attach most importance to night.
For the treatment of osteosarcoma and metastatic tumor of bone, often first-selected operation, but because postoperative recurrence needs row second operation, also may occur recurrence and transfer in addition, therefore Most patients and relatives are unwilling to accept this reality.Chemotherapy is owing to directly suppressing bone marrow hematogenesis function, and the leukocyte of patient reduces rapidly, and body constitution obviously weakens, and makes treatment have to interrupt.From traditional medicine, find active active drug that is strong, that have no side effect become the new way solving this problem.
Summary of the invention
The object of the present invention is to provide a kind of Be very effective, have no side effect, medication is convenient, treatment osteosarcoma osteodynia with low cost and the medicine of metastatic tumor of bone osteodynia.
For achieving the above object, the present invention takes following technical scheme:
The invention provides a kind of Chinese prescription for the treatment of osteosarcoma osteodynia and metastatic tumor of bone osteodynia, described Chinese prescription is prepared from by the raw material of Chinese medicine of following weight: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 10-15 part, Poria (Poria cocos (Schw.) Wolf) 10-15 part, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15-20 part, Radix Rehmanniae Preparata (Rehmannia glutinosa) 15-30 part, the Cortex Eucommiae (Eucommia ulmoides) 10-15 part, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15-20 part, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 15-30 part, Olibanum (Boswellia carterii Birdw.) 10-12 part, Pollen Typhae (Typha angustifolia L.) 10-15 part, Oletum Trogopterori (Faeces Trogopterori) 10-15 part, eupolyphaga (ground beetle) 8-10 part, the Radix Paeoniae Alba (Radix Paeoniae Alba) 15-30 part, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 15-30 part, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 5-15 part.
Preferably, a kind of Chinese prescription for the treatment of osteosarcoma osteodynia and metastatic tumor of bone osteodynia provided by the invention is prepared from by the raw material of Chinese medicine of following weight: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 12 parts, Poria (Poria cocos (Schw.) Wolf) 12 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15 parts, 20 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 12 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 30 parts, Olibanum (Boswellia carterii Birdw.) 10 parts, Pollen Typhae (Typha angustifolia L.) 10 parts, Oletum Trogopterori (Faeces Trogopterori) 10 parts, eupolyphaga (ground beetle) 10 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 30 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 30 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 10 parts.
Chinese medicine of the present invention according to traditional medicine and modern medical analysis, the property of medicine and pharmacological action as follows:
Radix Codonopsis: sweet in the mouth, property is put down.Return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI; For diseases such as deficiency of vital energy deficiency, fatigue and weakness, dyspnea with rapid breath, insufficiency of the spleen lack of appetite, the edema of the face, chronic diarrhea proctoptosis.
Poria: slightly sweet flavor, property are flat; Gui Jing: GUIXIN, lung, spleen channel; Function cures mainly: spleen invigorating, calm the nerves, calm, diuresis, also can promote body immune ability.
Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, has loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement for insufficiency of the spleen lack of appetite, abdominal distention.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function cures mainly: the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, and night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, vertigo and tinnitus, early whitening of beard and hair.
The Cortex Eucommiae: nature and flavor are sweet, temperature; Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Fructus Ligustri Lucidi: nature and flavor are sweet, bitter, cool; Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, improving eyesight, clearind deficient heat.
Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold.GUIXIN, Liver Channel.Function cures mainly: obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, and abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.
Olibanum: nature and flavor are pungent, bitter, temperature; GUIXIN, liver, spleen channel.Function cures mainly: obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, and lump in the abdomen is suffered from abdominal pain, rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection.
Pollen Typhae: nature and flavor are sweet, flat; Return liver, pericardium channel.Function cures mainly: spit blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, and amenorrhea stimulates the menstrual flow, breast ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Oletum Trogopterori: nature and flavor are bitter, sweet, warm; Return Liver Channel.Function cures mainly: function cures mainly: amenorrhea, dysmenorrhea, postpartum stagnation, breast abdomen pain, metrorrhagia, menorrhagia.
Eupolyphaga: nature and flavor are salty, cold, slightly poisonous; Return Liver Channel.Function cures mainly: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.
The Radix Paeoniae Alba: bitter, acid, to be slightly cold; Return liver, spleen channel.Function cures mainly: menoxenia, metrorrhagia, sweating due to debility, gastral cavity abdomen shoot, the pain over the hypochondriac region, limb pain twin, headache are dizzy.
Rhizoma Corydalis: pungent, bitter, temperature; Return liver, spleen channel.Function cures mainly: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Glycyrrhizae Preparata: taste is sweet, flat; GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Present invention also offers a kind of pharmaceutical preparation for the treatment of osteosarcoma osteodynia and metastatic tumor of bone osteodynia, the effective ingredient of described pharmaceutical preparation is prepared from according to pharmaceutical preparation customary preparation methods by above-mentioned Chinese prescription.In specific embodiment of the invention scheme, the effective ingredient of described pharmaceutical preparation is prepared by the following method: (1) prepares above-mentioned Chinese prescription; (2) above-mentioned Chinese prescription is concentrated into paste; (3) by extractum prepared by step (2), pharmaceutics conventional formulation technique is adopted to be prepared into various dosage form.
Further, said medicine preparation also comprises pharmaceutically conventional adjuvant, and described adjuvant can be lubricant, filler, disintegrating agent, correctives.Filler is selected from one or more in lactose, microcrystalline cellulose, sucrose, sorbitol, mannitol, starch, pregelatinized Starch; Disintegrating agent is selected from one or more in hydroxypropyl cellulose, Sodium Hydroxymethyl Stalcs, sodium carboxymethyl cellulose, sodium lauryl sulphate, Hexadecvlthio sodium succinate, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, sodium dioctyl sulfosuccinate; Lubricant is selected from one or more in Stepanol MG, silicon dioxide, Pulvis Talci, stearic acid, magnesium stearate, calcium stearate; Correctives includes but not limited to sucrose, polyhydric alcohol, glycerol, aspartame, cyclamate, stevioside.
Further, the dosage form of described pharmaceutical preparation is the conventional oral dosage formulations on pharmaceutics.Described peroral dosage form can be oral liquid, granule, pill, tablet, capsule.
The invention provides a kind of preparation method of above-mentioned Chinese prescription, the concrete steps of described preparation method are as follows:
(1) get it filled by above-mentioned raw material of Chinese medicine proportioning, clear water soaks;
(2) medicament mixed through soaking is put into drug-decocting appliance and decoct twice, first time adds 3 times amount soak by water and filters, and second time adds 2 times amount soak by water and filters;
(3) twice decoction liquor is merged, needed for gained Chinese medicine extract is.
Further, the concrete steps of the preparation method of above-mentioned Chinese prescription are as follows:
(1) get it filled by above-mentioned raw material of Chinese medicine proportioning, clear water soaks 6-10h;
(2) medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1-3h and filters, and second time adds 2 times amount soak by water 0.5-1.5h and filters;
(3) twice decoction liquor is merged, needed for the Chinese medicine extract of acquisition is.
In specific embodiment of the invention scheme, the concrete operation step of bolus of drug preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) ball is made by extractum group prepared by step (2), obtain pill.
In specific embodiment of the invention scheme, the concrete operation step of medicinal granule preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) extractum prepared by step (2) is added the starch of raw material of Chinese medicine total amount 1/10 weight portion, the sucrose of 1/10 weight portion, make granule; Or add the dextrin of raw material of Chinese medicine total amount 1/5 weight portion, make granule; Or add the aspartame of the starch of raw material of Chinese medicine total amount 1/5 weight portion, 1/2000 weight portion, make granule.
In specific embodiment of the invention scheme, the concrete operation step of medicine capsule preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) by extract dry prepared by step (2), pulverize and sieve, incapsulate shell, capsule.
In specific embodiment of the invention scheme, the concrete operation step of medicinal tablet preparation method is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) extractum prepared by step (2) is added the starch mixing of raw material of Chinese medicine total amount 1/5 weight portion, make granule, dry, tabletting, makes tablet.
In specific embodiment of the invention scheme, the concrete operation step of drug oral liquid and preparation method thereof is:
(1) Chinese medicine extract is prepared according to above-mentioned steps;
(2) extracting solution prepared by step (1) is concentrated into original 1/20, cold preservation, gets supernatant and is again concentrated into 2/3, cold preservation, centrifugal, the sucrose that centrifugal liquid adds raw material of Chinese medicine total amount 1/5 weight portion boils dosing, bottling, sealing sterilizing, obtained oral liquid.
Present invention also offers the application of above-mentioned Chinese prescription in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
Present invention also offers the application of said medicine preparation in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
Pharmaceutical preparation the present invention prepared is applied to osteosarcoma osteodynia patient, metastatic tumor of bone patient, detects therapeutic effect.Pharmaceutical preparation consumption: patient often takes the pharmaceutical preparation be equivalent to containing Radix Codonopsis 12g, Poria 12g, Rhizoma Atractylodis Macrocephalae 15g, Radix Rehmanniae Preparata 20g, Cortex Eucommiae 12g, Fructus Ligustri Lucidi 15g, Radix Salviae Miltiorrhizae 30g, Olibanum 10g, Pollen Typhae 10g, Oletum Trogopterori 10g, eupolyphaga 10g, Radix Paeoniae Alba 30g, Rhizoma Corydalis 30g, Radix Glycyrrhizae Preparata 10g day by day.
The primary tumor of metastatic tumor of bone of the present invention includes but not limited to breast carcinoma, pulmonary carcinoma, thyroid carcinoma, renal carcinoma, nasopharyngeal carcinoma, cervical cancer, gastric cancer, colon cancer, ovarian cancer, the esophageal carcinoma, melanoma, lymphoma.
Advantage of the present invention and beneficial effect:
(1) Chinese prescription of the present invention, pharmaceutical preparation the experiment proved that good effect, toxic and side effects are little, low price, are suitable for clinical universal use;
(2) Chinese prescription of the present invention can make the medicine of various ways, as capsule, tablet, pill, granule, meets the demand of different patient.
Detailed description of the invention
In order to understand better and implement, further illustrate the present invention below in conjunction with embodiment.If no special instructions, embodiments of the invention only for explaining the present invention, and do not mean that restriction protection scope of the present invention.
The preparation of embodiment 1 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 10 parts, Poria (Poria cocos (Schw.) Wolf) 10 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15 parts, 15 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 10 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 15 parts, Olibanum (Boswellia carterii Birdw.) 10 parts, Pollen Typhae (Typha angustifolia L.) 10 parts, Oletum Trogopterori (Faeces Trogopterori) 10 parts, eupolyphaga (ground beetle) 8 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 15 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 15 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 5 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 6h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1h and filters, and second time adds 2 times amount soak by water 0.5h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 2 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 15 parts, Poria (Poria cocos (Schw.) Wolf) 15 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 20 parts, 30 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 15 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 20 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 30 parts, Olibanum (Boswellia carterii Birdw.) 12 parts, Pollen Typhae (Typha angustifolia L.) 15 parts, Oletum Trogopterori (Faeces Trogopterori) 15 parts, eupolyphaga (ground beetle) 10 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 30 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 30 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 15 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 8h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 2h and filters, and second time adds 2 times amount soak by water 1h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 3 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 12 parts, Poria (Poria cocos (Schw.) Wolf) 12 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 18 parts, 18 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 12 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 18 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 18 parts, Olibanum (Boswellia carterii Birdw.) 11 parts, Pollen Typhae (Typha angustifolia L.) 12 parts, Oletum Trogopterori (Faeces Trogopterori) 11 parts, eupolyphaga (ground beetle) 9 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 20 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 20 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 10 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 10h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 3h and filters, and second time adds 2 times amount soak by water 1.5h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 4 Chinese prescription
1, the following raw material of Chinese medicine of precise: Radix Codonopsis (Codonopsis pilosula (Franch.) Nannf.) 12 parts, Poria (Poria cocos (Schw.) Wolf) 12 parts, Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala) 15 parts, 20 parts, Radix Rehmanniae Preparata (Rehmannia glutinosa), the Cortex Eucommiae (Eucommia ulmoides) 12 parts, Fructus Ligustri Lucidi (Fructus Ligustri Lucidi) 15 parts, Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bge.) 30 parts, Olibanum (Boswellia carterii Birdw.) 10 parts, Pollen Typhae (Typha angustifolia L.) 10 parts, Oletum Trogopterori (Faeces Trogopterori) 10 parts, eupolyphaga (ground beetle) 10 parts, the Radix Paeoniae Alba (Radix Paeoniae Alba) 30 parts, Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang) 30 parts, Radix Glycyrrhizae Preparata (RADIX GLYCYRRHIZAE PREPARATA) 10 parts.
2, raw material of Chinese medicine clear water will be mixed and soak 8h;
3, the medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1h and filters, and second time adds 2 times amount soak by water 0.5h and filters;
4, twice decoction liquor is merged, needed for gained Chinese medicine extract is.
The preparation of embodiment 5 pharmaceutical preparation
1, the preparation of oral liquid
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) extract prepared by step (1) is concentrated into original 1/20, cold preservation, gets supernatant and is again concentrated into 2/3, cold preservation, centrifugal, the sucrose that centrifugal liquid adds raw material of Chinese medicine total amount 1/5 weight portion boils dosing, bottling, sealing sterilizing, obtained oral liquid.
2, the preparation of pill
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) ball is made by extractum group prepared by step (2), obtain pill.
3, the preparation of granule
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) add the sucrose of the starch of raw material of Chinese medicine total amount 1/10 weight portion, 1/10 weight portion, make granule; Or add the dextrin of raw material of Chinese medicine total amount 1/5 weight portion, make granule; Or add the aspartame of the starch of raw material of Chinese medicine total amount 1/5 weight portion, 1/2000 weight portion, make granule.
4, the preparation of capsule
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) by extract dry prepared by step (2), pulverize and sieve, incapsulate shell, capsule.
5, the preparation of tablet
(1) Chinese medicine extract is prepared according to the method in embodiment 1,2,3 or 4;
(2) Chinese medicine extract prepared by step (1) is concentrated into paste;
(3) by extractum prepared by step (2), add the starch mixing of raw material of Chinese medicine total amount 1/5 weight portion, make granule, dry, tabletting, makes tablet.
The curative effect of embodiment 6 pharmaceutical preparation
1, study subject: 300 routine patients all derive from specific disease outpatient and inpatient, have trackability, all can coordinate experiment.200 routine patients undergoing surgery, the definitive pathological diagnosis such as bronchoscope and lymph node biopsy is malignant tumor, and the kind of malignant tumor comprises breast carcinoma, pulmonary carcinoma, thyroid carcinoma, renal carcinoma, nasopharyngeal carcinoma, cervical cancer, gastric cancer, colon cancer, ovarian cancer, the esophageal carcinoma, melanoma, lymphoma.Be diagnosed as metastatic tumor of bone through imaging examinations such as ECT, MRI, CT, x-ray, PET-CT, meet the patient of following standard simultaneously, the age is between 18-70 years old; Do not carry out the treatments such as metastatic tumor of bone local radiotherapy, chemotherapy, Diphosphonate and nucleic; Estimate that survival period was more than 6 months.Other 100 routine patients are through being diagnosed as Patients with Osteosarcoma.
2, Therapeutic Method: patient often takes the pharmaceutical preparation (can be oral liquid, granule, tablet or capsule) be equivalent to containing Radix Codonopsis 12g, Poria 12g, Rhizoma Atractylodis Macrocephalae 15g, Radix Rehmanniae Preparata 20g, Cortex Eucommiae 12g, Fructus Ligustri Lucidi 15g, Radix Salviae Miltiorrhizae 30g, Olibanum 10g, Pollen Typhae 10g, Oletum Trogopterori 10g, eupolyphaga 10g, Radix Paeoniae Alba 30g, Rhizoma Corydalis 30g, Radix Glycyrrhizae Preparata 10g day by day.The every bu of pharmaceutical preparation three picked-ups of above-mentioned dosage, take 3 months continuously.3 months post-evaluation curative effects.
3, efficacy assessment standard
Bone pain palliation rate is with reference to VRS method, and pain divides 4 grades, 0 grade: painless; I level: slight, pain can tolerate, and does not affect sleep, can orthobiosis; II level: moderate, pain is obvious, and can not tolerate, sleep is disturbed, and requires to take analgesic, can with autonomic nervous dysfunction or positive position; M level: severe, sharp ache, can not tolerate, sleep by severe jamming, need take analgesic, can with autonomic nervous dysfunction or positive position.Pain relieving standard: effective, pain relief more than II grade.Effective: pain relief I level.Invalid: pain slightly alleviates, but far less than I level or pain without alleviating or increasing the weight of.Evaluation on quality of life standard is scored by Kamofsky scoring criteria, and the increase >10 person of dividing that scores is raising; Reduce >10 and be divided into reduction; The increase and decrease <10 person of dividing is stable.
4, result
Use pharmaceutical preparation of the present invention treatment osteosarcoma osteodynia or Painful bone metastases effective percentage to reach more than 95%, the lighter one week, severe one is obviously alleviated for one month.
Table 1 bone pain palliation rate curative effect
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. treat the Chinese prescription of osteosarcoma osteodynia and metastatic tumor of bone osteodynia for one kind, it is characterized in that, described Chinese prescription is prepared from by the raw material of Chinese medicine of following weight: Radix Codonopsis 10-15 part, Poria 10-15 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Rehmanniae Preparata 15-30 part, Cortex Eucommiae 10-15 part, Fructus Ligustri Lucidi 15-20 part, Radix Salviae Miltiorrhizae 15-30 part, Olibanum 10-12 part, Pollen Typhae 10-15 part, Oletum Trogopterori 10-15 part, eupolyphaga 8-10 part, Radix Paeoniae Alba 15-30 part, Rhizoma Corydalis 15-30 part, Radix Glycyrrhizae Preparata 5-15 part.
2. Chinese prescription according to claim 1, it is characterized in that, described Chinese prescription is formulated by the raw material of Chinese medicine of following weight: Radix Codonopsis 12 parts, Poria 12 parts, Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Radix Rehmanniae Preparata, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 15 parts, Radix Salviae Miltiorrhizae 30 parts, Olibanum 10 parts, Pollen Typhae 10 parts, Oletum Trogopterori 10 parts, eupolyphaga 10 parts, the Radix Paeoniae Alba 30 parts, Rhizoma Corydalis 30 parts, Radix Glycyrrhizae Preparata 10 parts.
3. treat a pharmaceutical preparation for osteosarcoma osteodynia and metastatic tumor of bone osteodynia, it is characterized in that, the effective ingredient of described pharmaceutical preparation is prepared from by the Chinese prescription described in claim 1 or 2.
4. pharmaceutical preparation according to claim 3, is characterized in that, the dosage form of described pharmaceutical preparation is the conventional oral dosage formulations on pharmaceutics.
5. pharmaceutical preparation according to claim 4, is characterized in that, described peroral dosage form is oral liquid, granule, pill, tablet, capsule.
6. a preparation method for the Chinese prescription described in claim 1 or 2, is characterized in that, the concrete operation step of described preparation method is as follows:
(1) get it filled by the raw material of Chinese medicine proportioning described in claim 1 or 2, clear water soaks;
(2) medicament mixed through soaking is put into drug-decocting appliance and decoct twice, first time adds 3 times amount soak by water and filters, and second time adds 2 times amount soak by water and filters;
(3) twice decoction liquor is merged, needed for the Chinese medicine extract of acquisition is.
7. preparation method according to claim 6, is characterized in that, the concrete maneuvering sequence of described preparation method is as follows:
(1) get it filled by the raw material of Chinese medicine proportioning described in claim 1 or 2, clear water soaks 6-10h;
(2) medicament mixed through soaking is put into Traditional Chinese medicine decocting earthen pot and decoct twice, first time adds 3 times amount soak by water 1-3h and filters, and second time adds 2 times amount soak by water 0.5-1.5h and filters;
(3) bottling of twice decoction liquor is merged, needed for the drug extract of acquisition is.
8. the application of the Chinese prescription described in claim 1 or 2 in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
9. the application of the pharmaceutical preparation according to any one of claim 3-5 in preparation treatment osteosarcoma osteodynia and metastatic tumor of bone osteodynia medicine.
10. application according to claim 8 or claim 9, it is characterized in that, described medicine is the pharmaceutical preparation according to any one of claim 3-5.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267886A (en) * | 2015-11-28 | 2016-01-27 | 隋丽红 | Traditional Chinese medicine composition for treating osteosarcoma and plaster preparation method thereof |
| CN105853742A (en) * | 2016-05-30 | 2016-08-17 | 青岛辰达生物科技有限公司 | Pharmaceutical composition for thyroid cancer with osseous metastasis |
| CN106309585A (en) * | 2015-07-01 | 2017-01-11 | 上海中医药大学附属龙华医院 | Traditional Chinese medicinal composition with effect of relieving ostealgia of tumor patient, and application of traditional Chinese medicinal composition in pain-easing |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908563A (en) * | 2014-04-03 | 2014-07-09 | 荆振海 | Traditional Chinese medicine medicament for treating extraskeletal osteosarcoma and preparation method thereof |
-
2015
- 2015-03-24 CN CN201510130068.6A patent/CN104666658A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908563A (en) * | 2014-04-03 | 2014-07-09 | 荆振海 | Traditional Chinese medicine medicament for treating extraskeletal osteosarcoma and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 盛展能: "《抗癌治验本草》", 31 July 1994 * |
| 陈德货: "定痛汤加味治疗癌性疼痛45例", 《湖北中医杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309585A (en) * | 2015-07-01 | 2017-01-11 | 上海中医药大学附属龙华医院 | Traditional Chinese medicinal composition with effect of relieving ostealgia of tumor patient, and application of traditional Chinese medicinal composition in pain-easing |
| CN106309585B (en) * | 2015-07-01 | 2019-09-27 | 上海中医药大学附属龙华医院 | A kind of Chinese medicine composition improving tumor patient ostalgia and its application in analgesia |
| CN105267886A (en) * | 2015-11-28 | 2016-01-27 | 隋丽红 | Traditional Chinese medicine composition for treating osteosarcoma and plaster preparation method thereof |
| CN105853742A (en) * | 2016-05-30 | 2016-08-17 | 青岛辰达生物科技有限公司 | Pharmaceutical composition for thyroid cancer with osseous metastasis |
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