CN104666581B - For enhancing bone density and improving health products and its preparation of immunity - Google Patents
For enhancing bone density and improving health products and its preparation of immunity Download PDFInfo
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Abstract
The present invention provides a kind of health products and its preparation for enhancing bone density and improving immunity, which has effects that enhance bone density, repairs cartilaginous tissue and improve immunity.The product of the present invention is helped with dispelling wind and eliminating dampness, promoting blood circulation and removing blood stasis, taking into account improves rheumatism bone disease affected area adverse environment as mark, realizes treating both manifestation and root cause of disease with tonifying the liver and kidney as this.The product of the present invention has effects that treat cervical spondylosis, lumbar vertebra disease, degenerative knee, rheumatism or rheumatoid arthritis etc..The product of the present invention is using medicine materical crude slice cervus elaphus linnaeus, the root of bidentate achyranthes, prepared rehmannia root, pueraria lobata, Herba Epimedii etc., above each material combination, the interpretation of the cause, onset and process of an illness that osteoporosis of hitting kidney deficiency, spleen deficiency, the interpretation of the cause, onset and process of an illness of blood stasis and the laboured breathing of immunocompromised person kidney Tibetan the congenital essence and spleen transporting and transforming nutrients from foodstuff lose, complete square nourishing liver and kidney, invigorating the spleen, blood-nourishing, promoting blood circulation and removing blood stasis, strengthening the muscles and bones, strengthening vital QI to eliminate pathogenic factors, can reach increases the healthcare function of bone density and strengthen immunity, and has significant therapeutic effect to various osteopathy.
Description
Technical field
The present invention relates to traditional Chinese medicine health care product and its preparation fields, and in particular to one kind is immunized for enhancing bone density and improving
The preparation method of the health products of power and corresponding health products.
Background technology
The middle-aged and the old, especially 45 years old or more women, 50 years old or more male tend to osteoporosis, immunity occur low
Inferior situation carrys out the health care belt of the middle-aged and the old very big threat.Moreover, with the growth along with the age, people are also easy
Suffer from some osteopathy, such as cervical spondylosis, lumbar vertebra disease, gonarthrosis, rheumatoid arthritis.
At present, doctor trained in Western medicine generally believe osteoporosis be due to caused by calcium deficiency, for osteoporosis patient often
Most directly mode is taken, that is, is replenished the calcium, to improve bone density.Doctor trained in Western medicine thinks bone density, i.e. " bone mineral density ", is bone
The important symbol of bone quality, reflects osteoporosis degree, and bone density height can be as the important evidence of prediction fracture probability.
The health food for being presently used for increasing bone density mainly has：1. calcium：Calcium is body chats materialization tissue bone and tooth
The essential minerals of tooth is the basal nutrient for maintaining bone density and an important dietary factors for influencing bone density.When calcium is taken the photograph
Enter or when calcium uptake deficiency will induce hyperparathyroidism, the bone from bone is then caused to be mobilized, release is more
To maintain the calcium stable of serum, therefore bone loss occurs calcium.Therefore, status of the calcium in osteoporosis is prevented and treated is
It is extremely important and irreplaceable.2. vitamin D：The level of body vitamin D is closely related with bone density.Vitamin D is calcium
The main adjusting factor absorbed, can help absorption of human body calcium, effectively improve human bone mineral density.The quantity and effect of vitamin D
Can reduce may be the one of the major reasons that senile osteoporosis is caused to occur；Appropriate vitamin D can delay sclerotin
It loses, reduces incidence of fracture.3. isoflavones, soyasaponin.
But it is above-mentioned for substance for enhancing bone density, each mean that mark does not effect a permanent cure, be only according to bone
Composition corresponding substance is provided, do not find the basic sexual factor of enhancing bone density, do not have to the immune system of body yet
Any help.Moreover, these above-mentioned products produce little effect for the treatment of various osteopathy.
Accordingly it is desirable to there is a kind of product that can enhance bone density, treat osteopathy and improve the immunity of the human body.
Invention content
In view of the above-mentioned problems, the present invention is desirable to provide a kind of osteopathy that can fundamentally enhance bone density, treat human body
(lumbar vertebra disease, cervical spondylosis, arthritis etc.), and improve the preparation method of the health products of user's immunity and corresponding health care production
Product.
On the one hand, the present invention provides a kind of preparation method of health products for enhancing bone density and improving immunity, institute
The method of stating includes：
Step 1)：The root of bidentate achyranthes and prepared rehmannia root of predetermined amount are taken, the two is mixed and is placed in decocting the predetermined time in water；
Step 2)：Gained Aqueous extracts will be decocted to filter out, discard the dregs of a decoction；
Step 3)：Obtained Aqueous extracts are concentrated under reduced pressure, obtain the first thick medicinal extract；
Step 4)：The pueraria lobata and Herba Epimedii of predetermined amount are taken, one or many alcohol extractings are carried out to the two；
Step 5)：The alcohol extract obtained is concentrated, obtains the second thick medicinal extract；
Step 6)：First thick medicinal extract and second thick medicinal extract are merged, processing is dried, obtains dry extract；
Step 7)：The dry extract obtained is crushed and is filtered, obtains extract extract powder；
Step 8)：The cervus elaphus linnaeus of predetermined amount is taken, cervus elaphus linnaeus powder is made；
Step 9)：The cervus elaphus linnaeus powder is uniformly mixed with the extract extract powder.
Drying process is preferably using vacuum drying mode in the present invention, of course it is not excluded other drying sides can also be used
Formula.Water used herein can be the drinking water for meeting national standard, or purified water.
Further, the method, which further includes, carries out the cervus elaphus linnaeus60Co irradiation sterilizations, dosage 5kGy.
Further, the step 5) is put including weighing medicine materical crude slice pueraria lobata, the Herba Epimedii of formula ratio in (positive cone) extractor, point
Not plus 8-10 times is measured 70% ethyl alcohol, and refluxing extraction 2 times 2 hours every time, filters respectively, and merging filtrate obtains alcohol extract.
Further, by weight, used each material quantity is：70-90 parts of cervus elaphus linnaeus, 400-600 parts of the root of bidentate achyranthes, pueraria lobata
350-620 parts, 400-510 parts of prepared rehmannia root, 210-430 parts of Herba Epimedii.
Further, the method further includes adds in 120-140 parts of Divine Comedy, 75-95 parts of dried orange peel in said products.
On the other hand, the present invention provides a kind of health products for enhancing bone density and improving immunity, which is characterized in that
The health products include：It is cervus elaphus linnaeus, the root of bidentate achyranthes, pueraria lobata, prepared rehmannia root, Herba Epimedii or cervus elaphus linnaeus, the root of bidentate achyranthes, pueraria lobata, prepared rehmannia root, excessive
The extract of the sheep leaves of pulse plants.
Further, the powder of 70-90 parts of cervus elaphus linnaeus, 400-600 parts of the root of bidentate achyranthes and prepared rehmannia root are included in the health products
The dried powder of the alcohol extract of 210-430 parts of the dried powder of 400-510 parts of water extract, 350-620 parts of pueraria lobata and Herba Epimedii.
Further, the health products include the powder of 85 parts of cervus elaphus linnaeus, and the water of 450 parts of 500 parts of the root of bidentate achyranthes and prepared rehmannia root carries
The dried powder of the alcohol extract of 333 parts of the dried powder of object, 500 parts of pueraria lobata and Herba Epimedii.
On the other hand, the present invention provides a kind of application of the health products, which is characterized in that the health products are used to treat
Osteopathy.
Further, the osteopathy includes cervical spondylosis, lumbar vertebra disease, gonarthrosis, rheumatoid arthritis.The production of the present invention
Product mainly treat osteopathy by repairing damaged cartilage.
It should be noted that various raw materials of the present invention are commercially available conventional Chinese medicine.
The foundation and principle of formula of the present invention is described below.Applicant thinks osteopathy, either cervical vertebra
Disease, lumbar vertebra disease or gonarthrosis etc., morbidity are all impaired related with the tissues such as cartilage, fibrous ring and synovial membrane.Therefore, it repaiies
The tissues such as multiple damaged cartilage, fibrous ring and synovial membrane, make its regeneration, are the key that treatment osteopathy.
It is external source replacement therapy to repair damaged cartilage one kind, such as directly supplements cartilage, fibrous ring and synovial membrane group for human body
Main component ammonia sugar knitted etc., as a result, it has been found that curative effect is not very good, because ammonia sugar etc. is difficult to be directly absorbed by the body.
A kind of is the endogenous source therapy of Chinese Medicine Thinking, by ingeniously mending the tissues such as enhancing human body cartilage, fibrous ring and synovial membrane
Endogenous system --- (traditional Chinese medical science thinks liver kidney, liver governing tendons, Shen controls bone, so liver kidney is the groups such as human body cartilage, fibrous ring and synovial membrane
The endogenous origin head knitted), to repair the tissues such as impaired cartilage, fibrous ring and synovial membrane, make its regeneration, clinical effectiveness is agreed
It is fixed.
Chinese department of traditional Chinese medicine institute seat of honour rheumatism bone disease expert professor Feng Xinghua thinks that the treatment of rheumatism bone disease will be from morbidity
Source is set about, and using skilful filling liver kidney as this, is helped with dispelling wind and eliminating dampness, promoting blood circulation and removing blood stasis, and taking into account improves the unfavorable ring of rheumatism bone disease affected area
Border is mark, realizes treating both manifestation and root cause of disease." skilful filling liver kidney, regenerating bone or cartilage " reaches source side's (i.e. product of the invention), exactly Feng Xinghua religions
It awards by the clinical experience of the treatment rheumatism bone disease of more than 50 years and creates.This Fang Qiaoxuan's " tissues such as filling liver kidney, interior raw cartilage "
Medicinal material is strictly particular about monarch and channel tropism, the morbidity source for the rheumatism bone disease that goes directly.
The present invention is said from traditional Chinese medical science legislation, is broadly divided into two aspects " this and mark ", i.e. treating both manifestation and root cause of disease.
1. nourishment for vitality, double filling liver kidney (pilose antler, cultivated land etc.), effect a permanent cure.
The present invention by ingeniously selecting the Chinese medicine compatibilities of double filling liver kidney such as pilose antler, cultivated land, take later the cartilage of enhancing human body,
Fibrous ring and synovial membrane Endogenous system, that is, enhance hepatic and renal function, improves the self-regeneration energy to tissues such as cartilage, fibrous ring and synovial membranes
Power.
In addition, it is demonstrated experimentally that after the medicinal materials compatibility such as pilose antler, cultivated land takes, the conjunction of protein and nucleic acid can be effectively facilitated
Into, and protein and nucleic acid are the base substances of the generations such as cartilage, annulus fibrosus disci intervertebralis, synovium of joint, knuckle synovia.And
Pilose antler yang-tonifying, cultivated land enriching yin by the ingenious compatibility (both ingenious selections proportioning) of the Chinese medicines such as pilose antler, cultivated land, enhance human body
The Endogenous system of cartilage, fibrous ring and synovial membrane --- hepatic and renal function improves the reparation energy to human body cartilage, fibrous ring and synovial membrane
Power is realized and is effected a permanent cure from source.
2. dispelling wind and eliminating dampness, (Herba Epimedii, the root of bidentate achyranthes, pueraria lobata etc.) promoting blood circulation and removing blood stasis, take stopgap measures.
During liver this void of kidney, wind-cold damp pathogen easily invades human body, and numbness passages through which vital energy circulates, and blood vessels is caused to stagnate, osteopathy damaged part
Poor blood circulation, the nutrition supply and inflammation for being unfavorable for damaged part tissue are eliminated.
(1) removing cold and wind damp evil.The medicinal materials such as Herba Epimedii, can cold-dispelling damp evil and invigorating yangqi, can effectively release blood
Arteries and veins stagnates.
(2) it ensurings proper downward flow of the blood, it is promoting blood circulation and removing blood stasis.The root of bidentate achyranthes can ensuring proper downward flow of the blood and promoting blood circulation and removing blood stasis, and Herba Epimedii etc. can be coordinated to have
Effect improves the local environment of waist, knee damaged part, promotes blood circulation, and increases needed for endotrophic, swelling and pain relieving.
(3) rising Yang expelling pathogenic factors from muscles and skin is promoting blood circulation and removing blood stasis.Because of caused by liver and kidney deficiency, wind-cold damp pathogen invasion neck, qi and blood stagnation channels and collaterals lead to neck
Item is strong anxious, and muscle tendon and vessel is had a pain.Pueraria lobata is the good medicine for treating cervical spondylosis, can coordinate the removing cold and winds damp evil such as Herba Epimedii, Wen Tong
Yang-energy, rising Yang expelling pathogenic factors from muscles and skin, and the blood circulation at neck position can be promoted, accelerate the reparation of damaged cartilage, fibrous ring etc..
The present invention by the ingenious compatibilities of the Chinese medicines such as Herba Epimedii, the root of bidentate achyranthes, pueraria lobata (proportioning of three kinds of medicinal materials of ingenious selection),
Removing cold and wind damp evil, invigorating yangqi, swelling and pain relieving is promoting blood circulation and removing blood stasis, improves osteopathy damaged part blood circulation, increases impaired soft
The nutrition supply of bone, fibrous ring and synovial membrane etc., realization take stopgap measures.
Therefore, product of the invention can enhance bone density, repair cartilaginous tissue, and for lumbar vertebrae, cervical vertebra, arthritis
Etc. osteopathy can realize treating both manifestation and root cause of disease.
Description of the drawings
Fig. 1 is the simplification of flowsheet figure of the health products preparation method of the present invention.
Fig. 2 is the refined flow chart of the health products preparation method of the present invention.
Specific embodiment
The embodiment of the present invention is further elaborated with reference to Fig. 1 and Fig. 2.
Embodiment one
1st, raw material, auxiliary material requirement and pre-treatment
Prepare raw material medicine materical crude slice cervus elaphus linnaeus, the root of bidentate achyranthes, prepared rehmannia root, pueraria lobata, Herba Epimedii and supplementary product starch, magnesium stearate etc. respectively.
And prepare to be used to extract the drinking water or purified water with preparation.
Medicine materical crude slice cervus elaphus linnaeus is carried out60Co irradiation sterilizations, dosage 5kGy, the cervus elaphus linnaeus after irradiation are spare；It is the medicine materical crude slice root of bidentate achyranthes, ripe
Glutinous rehmannia, pueraria lobata, Herba Epimedii are weighed respectively by formula ratio, spare；Supplementary product starch, magnesium stearate cross 80 mesh sieve respectively, by formula ratio
It weighs, it is spare.
Each raw material proportioning such as following table：
2nd, it feeds intake, extract
The medicine materical crude slice root of bidentate achyranthes, the prepared rehmannia root for weighing formula ratio are put in positive cone extractor, and respectively plus 10 times of amount (purifying) water, decoction carry
It takes 2 times, extracts 1.5h every time, filter respectively, merging filtrate obtains Aqueous extracts.The dregs of a decoction discard.
Medicine materical crude slice pueraria lobata, the Herba Epimedii for weighing formula ratio are put in positive cone extractor, and respectively plus 8 times of 70% ethyl alcohol of amount, reflux carry
It takes 2 times, 2 hours every time, filters respectively, merging filtrate obtains alcohol extract.The dregs of a decoction discard.
3rd, it concentrates
Aqueous extracts are put in vacuum concentration pot, are concentrated under reduced pressure into relative density 1.20-1.25 (being measured under the conditions of about 60 DEG C),
Obtain thick medicinal extract I.Technological parameter is concentrated under reduced pressure：65~75 DEG C of vacuum degree 0.08MPa, temperature.
Alcohol extract is put in vacuum concentration pot, is concentrated under reduced pressure into no alcohol taste, recycles ethyl alcohol, and continue to be concentrated into relative density
1.20-1.25 (is measured) under the conditions of about 60 DEG C, obtains thick medicinal extract II.Technological parameter is concentrated under reduced pressure：Vacuum degree 0.08MPa, temperature 55
~65 DEG C.
4th, dry, crushing
Thick medicinal extract I with thick medicinal extract II is merged, puts in vacuum drying chamber and is dried in vacuo (technological parameter：Vacuum degree
0.08MPa, 70~80 DEG C of temperature), dry extract is obtained, dry extract is put in pulverizer and is crushed, 80 mesh sieve is crossed, obtains extract medicinal extract
Powder, it is spare.
It will be through60The cervus elaphus linnaeus of Co irradiation sterilizations, which is put in pulverizer, to be crushed, and is crossed 80 mesh sieve, is obtained cervus elaphus linnaeus powder, claim by formula ratio
It takes, it is spare.
5th, it mixes
Said extracted object extract powder, cervus elaphus linnaeus powder, starch and magnesium stearate are put in mixing machine and mixed 20 minutes, must be mixed
Powder.Mixed powder answers uniform color consistent, no color differnece.
6th, capsule is filled, polishes, select capsule
Mixed powder Autocapsulefillingmachine is filled into capsule, using 0# Capsules, filling specification is 0.45g/,
Content uniformity is controlled in the range of ± 5%.By the capsule after filling in being polished in capsule polisher, inferior etc. do not conform to is removed
Lattice product.
7th, inner packing
By qualified capsule be packed into plastic bottle, 60 every bottle.Packaging material is oral stable medicinal polythene bottle with high density (symbol
Close the standard requirement of YBB00122002).
8th, outer packing, product inspection, storage：
Labelling, vanning.Every batch of product is randomly selected, is tested according to quality standard the method and requirement, is examined
After qualification, warehousing finished products.
9th, production environment and management should meet the requirement of health food GMP, be dried in vacuo, crush in production process, being sieved,
Mixing, capsule filling and inner packing process are under the conditions of the production clean area that GB17405-1998 is required (for 100,000 grades) is met
Operation.
After the product for preparing the present invention, in order to verify the effect of the present invention, need to face the product of the present invention
Bed verification.Specifically, applicant provides this in clinic to patient of the positions up to a hundred with arthritis, lumbar vertebra disease or cervical spondylosis
The product of invention carries out clinical verification (in the case where appointing confidentiality obligations), then, after taking medicine respectively to up to a hundred patients
Effect carry out regular further consultation.
By being measured to these bone mineral densities, it is found that patient 2-3 weeks after the tablet has been ingested, bone density will significantly increase
Add, also, cervical spondylosis and lumbar vertebra disease can all have apparent improvement.And 4-6 weeks after the tablet has been ingested, synovitis, rheumatoid arthritis
Etc. diseases can all be almost recovered.Moreover, by the measure to pill taker's immunity albumen, it has also been discovered that, medication patient is taking
The content of immune protein increases after medicine.
Therefore, it is sufficient to which bone density can be enhanced by proving the product of the present invention, treated osteopathy also, improved the immunity of the human body.
And currently used medicine, or osteopathy is often treated only for bone density or only, it is difficult to both realize that bone was close
The increase of degree, and realize the treatment of osteopathy and the promotion of immunity.
Embodiment two
In the present embodiment, used preparation method and embodiment one are essentially identical, each component content being only formulated
Appropriate adjustment is carried out.
This formula more stresses effecting a permanent cure for osteopathy, therefore, more long-acting after taking.
Embodiment three
In the present embodiment, used preparation method and embodiment one are substantially similar, are only to be fitted in formula
Work as adjustment.
Specifically, its formula such as following table
In above-mentioned material, Morinda officinalis and the fruit of Chinese wolfberry are using (in the step of alcohol extracting add in) by the way of alcohol extracting, alcohol extracting
After obtain dried powder.Amomum cardamomum, Divine Comedy, dried orange peel (add in) in a manner that water carries in the step of water carries.On being added to
After stating auxiliary material, the effect for treating osteopathy is more preferable, stimulates smaller to the stomach of patient, people digest is promoted to absorb.
It should be noted that, although the present invention is described in detail above in conjunction with specific embodiments and the drawings, but
It is that above description only schematically illustrates, in order to those skilled in the art's the understanding of the present invention, shown in figure
The detail of part is not the restriction to invention protection domain.Those skilled in the art it should also be understood that above-described embodiment also only
Only it is the explanation to the exemplary implementation of the present invention, not limiting the scope of the invention.
Claims (4)
1. a kind of preparation method of health products for enhancing bone density and improving immunity, the method includes：
Step 1)：90 parts of 450 parts of 300 parts of the root of bidentate achyranthes, prepared rehmannia root, 80 parts of Amomum cardamomum, 120 parts of Divine Comedy and the dried orange peel of predetermined amount are taken, it will
Its mixing is placed in decocting the predetermined time in water；
Step 2)：Gained Aqueous extracts will be decocted to filter out, discard the dregs of a decoction；
Step 3)：Obtained Aqueous extracts are concentrated under reduced pressure, obtain the first thick medicinal extract；
Step 4)：60 parts of 400 parts of pueraria lobata, 333 parts of Herba Epimedii, 162 parts of Morinda officinalis and the fruit of Chinese wolfberry are taken, it is carried out one or many
Alcohol extracting；
Step 5)：The alcohol extract obtained is concentrated, obtains the second thick medicinal extract；
Step 6)：First thick medicinal extract and second thick medicinal extract are merged, processing is dried, obtains dry extract；
Step 7)：The dry extract obtained is crushed and is filtered, obtains extract extract powder；
Step 8)：85 parts of cervus elaphus linnaeus is taken, cervus elaphus linnaeus powder is made；
Step 9)：The cervus elaphus linnaeus powder is uniformly mixed with the extract extract powder.
2. the preparation method of health products according to claim 1, which is characterized in that the method is further included to the red deer
Young pilose antler carries out60Co irradiation sterilizations, dosage 5kGy.
3. the preparation method of health products according to claim 1, which is characterized in that the step 4) is including weighing formula ratio
Medicine materical crude slice pueraria lobata, Herba Epimedii, Morinda officinalis and the fruit of Chinese wolfberry be placed in positive cone extractor, respectively plus 8-10 times measure 70% ethyl alcohol, flow back
Extraction 2 times, 2 hours every time, filters, merging filtrate obtains alcohol extract respectively.
4. a kind of health products for enhancing bone density and improving immunity, which is characterized in that the health products include：The root of bidentate achyranthes
300 parts, 450 parts of prepared rehmannia root, 80 parts of Amomum cardamomum, 120 parts of Divine Comedy and the water extract of 90 parts of dried orange peel and 400 parts of pueraria lobata, Herba Epimedii
333 parts, the alcohol extract of 60 parts of 162 parts of Morinda officinalis and the fruit of Chinese wolfberry also include the powder of 85 parts of cervus elaphus linnaeus in the health products, and
The health products are prepared using method described in claim 1.
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| CN105249463A (en) * | 2015-11-19 | 2016-01-20 | 哈尔滨圣吉药业股份有限公司 | Health food with function of enhancing bone mineral density and production method thereof |
| CN113170883A (en) * | 2021-04-26 | 2021-07-27 | 吉林大清鹿苑保健科技有限公司 | Health food for increasing bone mineral density and preparation method thereof |
Citations (2)
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|---|---|---|---|---|
| CN102626463A (en) * | 2012-05-07 | 2012-08-08 | 赵全成 | Natural medicine compound for increasing bone mineral density and preventing and treating osteoporosis |
| CN102885304A (en) * | 2012-10-12 | 2013-01-23 | 中科乐仁（北京）科技发展有限公司 | BMD (bone mineral density)-increased health food composite and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102626463A (en) * | 2012-05-07 | 2012-08-08 | 赵全成 | Natural medicine compound for increasing bone mineral density and preventing and treating osteoporosis |
| CN102885304A (en) * | 2012-10-12 | 2013-01-23 | 中科乐仁（北京）科技发展有限公司 | BMD (bone mineral density)-increased health food composite and preparation method thereof |
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| Title |
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| [国食健字G20120550]方中方牌达源胶囊;北京方中方科技有限公司;《http://www.jianzihao.com/view-20653》;20121222;1-5 * |
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