CN104651665A - Corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy capable of being degraded in human body and application of corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy - Google Patents
Corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy capable of being degraded in human body and application of corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
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Abstract
The invention discloses a corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy capable of being degraded in a human body and an application of the corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy, relates to field of medical implantation materials, and provides the corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy which is low in cost of added materials, high in strength, good in plasticity and controllable in degradation rate, has non-expanding and non-migrating degradation products and can be simultaneously degraded in the human body against the defects in the prior art. The zinc alloy comprises Zn, Fe and Li elements, wherein the content of the Zn element in mass percentage is 80-99.997%, the content of the Fe element in mass percentage is 0.002-10%, and the content of the Li element in mass percentage is 0.001-10%. The cost of the materials added into the zinc-based alloy disclosed by the invention is low, the degradation products of various components in the prepared alloy material can be degraded in the human body by metabolism, the corrosion resistance is much higher than that of a magnesium alloy, the degradation speed is greatly reduced, the mechanical support can be provided for a longer time, and the alloy material has good strength and toughness.
Description
Technical field
The present invention relates to the degradable corrosion-proof and high-strength of a kind of human body tough Zn-Fe-Li system zinc alloy, belong to medical embedded material technical field.
Background technology
Zine ion is the nutritive element of needed by human, participates in the metabolic activity that human body is a lot.U.S. clinical creative design (ACI) recommends human body must take in the zinc of 2.5 to 6.4 milligrams every day, and grownup takes in about 300 milligrams of zinc every day just may have certain toxic reaction.The zinc of one piece of zinc-base degradable bone peg release every day is approximately 0.2 ~ 0.3 milligram, even if these zine ions are all discharged in blood vessel, also well below the intake of needed by human.That is, the zine ion of zinc-base degradable orthopaedics implantation instrument degraded release can not cause general toxicity.Research also finds, the transport of zine ion in tissue is very fast, therefore there will not be zinc enrichment, cytotoxicity or necrosis near zinc-base degradable orthopaedics implantation instrument.
The function of zine ion in human body is a lot, and extremely important to human body, a wherein very important function promotes bone growth exactly.Researchist finds the aminoacyl-tRNA synthetase that can activate due to zine ion in scleroblast, and effectively can suppress differentiation and the growth of osteoclast, therefore the existence of zine ion not only facilitates the increase of bone calcium salt content, also help the raising of bone collagen content, this illustrates that zine ion has directly short osteogenesis function.In addition, research also finds that zine ion promotes the combination of cartilage oligomeric matrix protein and collagen, is the catalytic elements of cartilage growth and regeneration.
Traditional intravascular stent generally adopts nondegradable metal to make, and its shortcoming is metal non-degradable, cannot takes out, and is trapped in Ink vessel transfusing and easily causes advanced thrombus.A large amount of clinical cases confirms patient to implant this kind of support, and after 1 ~ 5 year, thrombosis rate is up to 3% ~ 9%, and after thrombosis, mortality ratio is up to 30%.Nail and hone lamella are conventional fixing fracture and the medical implantation instrument of ligament injury, and traditional nail and hone lamella cannot be taken out by nondegradable metal, must carry out second operation, bring great wound to patient.Meanwhile, traditional metal materials intensity is too high, easily brings stress shielding, causes injured osseous tissue to be difficult to regeneration and healing.
In human body, degradable medical material is becoming the emphasis of research and development, and wherein degradable high polymer material, pure iron and ferrous alloy, pure magnesium and magnesium based alloys are the most deep materials of research in recent years.Degradable high polymer material intensity is too low, in Clinical practice process, often fracture accident can occur, and clinical applicability receives very big restriction.The intensity of pure iron and ferrous alloy and toughness are far above macromolecular material, but the degradation speed of iron is too slow, and the degradable time may reach the several years.More seriously, the iron rust shape mass volume generated in iron degradation process expands several times, and has obvious migration trend.The degraded product of pure magnesium and magnesium based alloys is nontoxic, degradable, but the non-constant of its solidity to corrosion, will soon be degraded in human body, the enough mechanical support time cannot be provided.
Pure zinc and alloy thereof are also degradable materials under a kind of human body environment, but be applied in medical material aspect and still have that mechanical strength is low, the uncontrollable shortcoming of degradation rate, all improve mechanical property and regulation and control degradation rate by adding other material to reach to it at present, Ce, Mg, Cu, Ca is added in zinc disclosed in application number 201310756776.1, but zinc alloy material plasticity prepared by this application is lower, and also do not find the adding material of cheap iron as zinc at present, use as bio-medical material.
Summary of the invention
The object of the invention is the deficiency existed for existing medical embedded material, there is provided a kind of adding material cost low, intensity is high, plasticity good, and degradation rate is controlled, degraded product does not expand, do not move, the Zn-Fe-Li system zinc alloy simultaneously can degraded by human body and application thereof.
The invention provides the degradable corrosion-proof and high-strength of a kind of human body tough Zn-Fe-Li system zinc alloy, described zinc alloy comprises Zn, Fe and Li element, wherein the mass percentage of Zn element is: 80 ~ 99.997%, the mass percentage of Fe element is: the mass percentage of 0.002 ~ 10%, Li element is: 0.001 ~ 10%.
Based on the composition of above alloy material, in order to optimize mechanical property and biological corrosion performance, we are at alloy optimization of material: in described zinc alloy, the mass percentage of Zn element is: 90 ~ 99.993%, the mass percentage of Fe element is: the mass percentage of 0.005 ~ 8%, Li element is: 0.002 ~ 2%.
More preferably, also comprise trace element in described zinc alloy, described trace element is at least one in Mg, Ca, Sr, Si, Mn and rare earth element, and the mass ratio of described trace element and Zn element is 0 ~ 0.0625:1.
Based on the composition of above alloy material, in order to optimize mechanical property and biological corrosion performance, we are optimized for by alloy material further, and in described zinc alloy, trace element is 0 ~ 0.025:1 with the mass ratio of Zn.
The degradable corrosion-proof and high-strength of human body prepared by foregoing invention tough Zn-Fe-Li system zinc alloy, uses the method for this area routine to be prepared into degradable medical implant.
Therefore, the present invention also provides the degradable corrosion-proof and high-strength of a kind of human body tough Zn-Fe-Li system zinc alloy preparing the application in degradable medical apparatus material.
Described degradable medical apparatus is implant frame, orthopaedics implantation instrument, gear division implantation instrument, operating sutures or stapler.Wherein implant frame comprises intravascular stent, trachea bracket, urethra rack, esophageal stents appear, intestinal stent or biliary tract rack; Orthopaedics implantation instrument comprises retaining screw, fixing rivet, hone lamella, bone cover, intramedullary needle or bone tissue restoration support; Stapler comprises bowel anastomosis device, blood vessel anastomat or dialyneury device.
The present invention has following beneficial effect:
1, adding material is with low cost, and each ingredient degradation product of alloy material of preparation can be degraded by body metabolism;
2, solidity to corrosion is far above magnesium alloy, and degradation rate is controlled, and degraded product does not expand, do not move;
3, alloy material intensity and good toughness.Iron has the dual function of solution strengthening and precipitation strength at a room temperature and a high temperature, can with Zn formed plurality of stable intermetallic compound, play strengthening effect, and have crystal grain thinning, improve the effect of plasticity, improve alloy material intensity and toughness.
Accompanying drawing explanation
Fig. 1 is that alloy of the present invention is degraded microstructure schematic diagram in animal body.
Embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
Due to the difference of coenocorrelation and functional requirement, the different requirement of degradable implantation instrument to degradation speed is different.Zinc corrosion potential be-0.76V, the corrosion potential of iron is-0.44V, therefore iron adds in zinc as alloying element and can produce two kinds of reverse effects simultaneously, and the first effect is that ferro element is solidly soluted in matrix zinc, and the corrosion potential of zinc reduces, solidity to corrosion strengthens, degradation speed reduces; The second effect is that ferro element and zinc element generate granular compound, forms microbattery, solidity to corrosion declines, degradation speed raises with matrix zinc.By regulating the content of iron, the degradation speed controlling zinc alloy can be reached and make it be suitable for the requirement of medical embedded material.
Embodiment 1
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe-Li system zinc alloy, its elementary composition and mass percent is: Zn 80%, Fe 10%, Li 10%.
Embodiment 2
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe-Li system zinc alloy, its elementary composition and mass percent is: Zn 99.997%, Fe 0.002%, Li 0.001%.
Embodiment 3
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe-Li system zinc alloy, its elementary composition and mass percent is: Zn 99.975%, Fe 0.01%, Li 0.015%.
Embodiment 4
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe-Li system zinc alloy, its elementary composition and mass percent is: Zn 97%, Fe 1%, Li 1%, Mg 1%.
Embodiment 5
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe-Li system zinc alloy, its elementary composition and mass percent is: Zn 95.5%, Fe 2%, Li 2%, Ce 0.5%.
Embodiment 6
With the zinc alloy that elementary composition use this area routine techniques in embodiment 1 ~ 5 is obtained, carry out simulated body fluid soak test, test Zn-Fe-Li system zinc alloy degradation rate experimental results is as table one:
Table one
The present embodiment is studied the external degradation mechanism of zinc-base Zn-Fe-Li system alloy and degradation property according to ASTM-G31-72 standard method of test, the simulated body fluid simulated body fluid environment of 37 degrees Celsius, find that the degradation speed of Zn-Fe-Li system zinc alloy is slow and controlled in this environment.Li is a kind of very active metallic element, very easily oxidation and corrosion reaction occurs, and can be used for regulating the degradation process accelerating Zn and Fe.
Embodiment 7
With the zinc alloy that elementary composition use this area routine techniques in embodiment 1 ~ 5 is obtained, carry out tensile strength test result as shown in Table 2.
Table two
The present embodiment is according to GB/T228.1-2010 testing standard, and carry out stretching mechanical property testing to Zn-Fe-Li system zinc alloy embodiment 1 ~ 5, result as shown in Table 2.Find that Zn-Fe-Li system zinc alloy yield strength reaches as high as 290MPa, tension set is up to 36%, this is because iron and zinc generate the tiny compound particle of Dispersed precipitate, reach the effect of crystal grain thinning, can improve thermostability and the creep resistance of zinc alloy, the trace element added then improves material mechanical performance further.
Embodiment 8
With the zinc alloy that elementary composition use this area routine techniques in embodiment 1 ~ 5 is obtained, carry out vitro cytotoxicity test.
The present embodiment has carried out vitro cytotoxicity test according to GB/T 16886.5-2003 to zinc alloy, inoblast L-929 is cultivated in the extracting solution of zinc alloy degraded product, measure the cytoactive of 24 hours and 72 hours, and compare in the cytoactive of cellar culture liquid with cultivation, find that the cytoactive of cultivation in zinc alloy degraded product extracting solution is all higher than 90%, and cell morphology is in the pink of condition, therefore can think that zinc alloy degraded product does not affect cytoactive, cell does not have toxic reaction to zinc alloy degraded product.
Embodiment 9
With the zinc alloy that elementary composition use this area routine techniques in embodiment 1 is obtained, carry out et al. Ke test.Zinc alloy prepared by embodiment 1 is made filament to implant in New Zealand white rabbit aorta abdominalis 12 months, as shown in Figure 1, in figure, clear zone is B alloy wire cross section, and the gray area being close to B alloy wire is degraded product, and black region is the resin material of fixed sample.Research finds that B alloy wire does not find the situation of any expansion and migration after degradation, and its degraded product still maintains original shape, not have discovery to drop the phenomenon of particle, fragment.Carry out et al. Ke test equally to alloy material prepared by other embodiment, the micro-image obtained is similar to the zinc alloy of embodiment 1 simultaneously.
Above content is the further description done the present invention in conjunction with concrete embodiment, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (6)
1. the degradable corrosion-proof and high-strength of a human body tough Zn-Fe-Li system zinc alloy, it is characterized in that: described zinc alloy comprises Zn, Fe and Li element, wherein the mass percentage of Zn element is: 80 ~ 99.997%, the mass percentage of Fe element is: the mass percentage of 0.002 ~ 10%, Li element is: 0.001 ~ 10%.
2. the tough Zn-Fe-Li system of the degradable corrosion-proof and high-strength of human body as claimed in claim 1 zinc alloy, it is characterized in that: in described zinc alloy, the mass percentage of Zn element is: 90 ~ 99.993%, the mass percentage of Fe element is: the mass percentage of 0.005 ~ 8%, Li element is: 0.002 ~ 2%.
3. the tough Zn-Fe-Li system of the degradable corrosion-proof and high-strength of human body as claimed in claim 1 or 2 zinc alloy, it is characterized in that: in described zinc alloy, also comprise trace element, described trace element is at least one in Mg, Ca, Sr, Si, Mn and rare earth element, and the mass ratio of described trace element and Zn element is 0 ~ 0.0625:1.
4. the tough Zn-Fe-Li system of the degradable corrosion-proof and high-strength of human body as claimed in claim 3 zinc alloy, is characterized in that: the mass ratio of described zinc alloy medium trace element and Zn element is 0 ~ 0.025:1.
5. the application in degradable medical apparatus material prepared by the degradable corrosion-proof and high-strength of the human body according to any one of a Claims 1 to 4 tough Zn-Fe-Li system zinc alloy.
6. the application in degradable medical apparatus material prepared by the tough Zn-Fe-Li system of the degradable corrosion-proof and high-strength of human body as claimed in claim 5 zinc alloy, it is characterized in that: described degradable medical apparatus is implant frame, orthopaedics implantation instrument, gear division implantation instrument, operating sutures or stapler; Wherein implant frame comprises intravascular stent, trachea bracket, urethra rack, esophageal stents appear, intestinal stent or biliary tract rack; Orthopaedics implantation instrument comprises retaining screw, fixing rivet, hone lamella, bone cover, intramedullary needle or bone tissue restoration support; Stapler comprises bowel anastomosis device, blood vessel anastomat or dialyneury device.
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| CN201510111250.7A CN104651665B (en) | 2015-03-13 | 2015-03-13 | A kind of tough Zn-Fe-Li systems kirsite of the degradable corrosion-proof and high-strength of human body and its application |
| PCT/CN2016/073439 WO2016145958A1 (en) | 2015-03-13 | 2016-02-04 | Corrosion-resistant, high strength and ductility zn-fe-li zinc alloy degradable by the human body and applications of the alloy |
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| CN201510111250.7A CN104651665B (en) | 2015-03-13 | 2015-03-13 | A kind of tough Zn-Fe-Li systems kirsite of the degradable corrosion-proof and high-strength of human body and its application |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145958A1 (en) * | 2015-03-13 | 2016-09-22 | 西安爱德万思医疗科技有限公司 | Corrosion-resistant, high strength and ductility zn-fe-li zinc alloy degradable by the human body and applications of the alloy |
| CN106377795A (en) * | 2016-08-25 | 2017-02-08 | 上海交通大学 | Degradable medical Zn-Li-Fe ternary alloy material, preparation and application |
| CN106974718A (en) * | 2016-01-15 | 2017-07-25 | 西安爱德万思医疗科技有限公司 | A kind of bone screw |
| CN107460371A (en) * | 2016-06-02 | 2017-12-12 | 北京大学 | A kind of Zn-Li systems kirsite and preparation method and application |
| CN107773781A (en) * | 2016-08-29 | 2018-03-09 | 上海交通大学 | The preparation method of flexible degradable kirsite nerve trachea |
| CN108315583A (en) * | 2018-03-23 | 2018-07-24 | 北京大学 | A kind of Zn-Li-Mn systems kirsite and the preparation method and application thereof |
| CN110512117A (en) * | 2019-09-27 | 2019-11-29 | 石家庄新日锌业有限公司 | Medical zinc alloy material and preparation method thereof |
| CN112899527A (en) * | 2021-01-20 | 2021-06-04 | 湖南华锐科技集团股份有限公司 | Degradable zinc alloy bar and preparation method thereof |
| US11351290B1 (en) | 2020-04-08 | 2022-06-07 | Admtech, Llc | Absorbable high-strength zinc alloy for medical implants |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102634725A (en) * | 2012-03-31 | 2012-08-15 | 大连理工大学 | Biomedical corrodible degradation bi-component Fe-Zn alloy material |
| CN103736152A (en) * | 2013-12-26 | 2014-04-23 | 西安爱德万思医疗科技有限公司 | Anti-corrosion high-toughness zinc alloy implant material capable of being absorbed by human body |
| CN104195368A (en) * | 2014-08-21 | 2014-12-10 | 北京大学 | Zn-Sr series zinc alloy as well as preparation method and application of Zn-Sr series zinc alloy |
| CN104195369A (en) * | 2014-08-21 | 2014-12-10 | 北京大学 | Zn-Ca series zinc alloy as well as preparation method and application of Zn-Ca series zinc alloy |
| CN104328312A (en) * | 2014-10-20 | 2015-02-04 | 东北大学 | Medical biodegradable zinc alloy and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005018356B4 (en) * | 2005-04-20 | 2010-02-25 | Eurocor Gmbh | Resorbable implants |
| DE102007042451A1 (en) * | 2007-09-06 | 2009-03-12 | Biotronik Vi Patent Ag | Stent with a body made of a biocorrodible alloy |
| CN104651665B (en) * | 2015-03-13 | 2017-11-03 | 西安爱德万思医疗科技有限公司 | A kind of tough Zn-Fe-Li systems kirsite of the degradable corrosion-proof and high-strength of human body and its application |
-
2015
- 2015-03-13 CN CN201510111250.7A patent/CN104651665B/en active Active
-
2016
- 2016-02-04 WO PCT/CN2016/073439 patent/WO2016145958A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102634725A (en) * | 2012-03-31 | 2012-08-15 | 大连理工大学 | Biomedical corrodible degradation bi-component Fe-Zn alloy material |
| CN103736152A (en) * | 2013-12-26 | 2014-04-23 | 西安爱德万思医疗科技有限公司 | Anti-corrosion high-toughness zinc alloy implant material capable of being absorbed by human body |
| CN104195368A (en) * | 2014-08-21 | 2014-12-10 | 北京大学 | Zn-Sr series zinc alloy as well as preparation method and application of Zn-Sr series zinc alloy |
| CN104195369A (en) * | 2014-08-21 | 2014-12-10 | 北京大学 | Zn-Ca series zinc alloy as well as preparation method and application of Zn-Ca series zinc alloy |
| CN104328312A (en) * | 2014-10-20 | 2015-02-04 | 东北大学 | Medical biodegradable zinc alloy and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王伟强等: "Ｆe－Ｚｎ合金的粉末冶金法制备及其生物降解特性研究", 《功能材料》 * |
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| WO2016145958A1 (en) * | 2015-03-13 | 2016-09-22 | 西安爱德万思医疗科技有限公司 | Corrosion-resistant, high strength and ductility zn-fe-li zinc alloy degradable by the human body and applications of the alloy |
| CN106974718A (en) * | 2016-01-15 | 2017-07-25 | 西安爱德万思医疗科技有限公司 | A kind of bone screw |
| CN107460371A (en) * | 2016-06-02 | 2017-12-12 | 北京大学 | A kind of Zn-Li systems kirsite and preparation method and application |
| CN107460371B (en) * | 2016-06-02 | 2019-01-22 | 北京大学 | A kind of Zn-Li system kirsite and the preparation method and application thereof |
| CN106377795A (en) * | 2016-08-25 | 2017-02-08 | 上海交通大学 | Degradable medical Zn-Li-Fe ternary alloy material, preparation and application |
| CN107773781A (en) * | 2016-08-29 | 2018-03-09 | 上海交通大学 | The preparation method of flexible degradable kirsite nerve trachea |
| CN108315583A (en) * | 2018-03-23 | 2018-07-24 | 北京大学 | A kind of Zn-Li-Mn systems kirsite and the preparation method and application thereof |
| CN110512117A (en) * | 2019-09-27 | 2019-11-29 | 石家庄新日锌业有限公司 | Medical zinc alloy material and preparation method thereof |
| CN110512117B (en) * | 2019-09-27 | 2022-05-13 | 石家庄新日锌业有限公司 | Medical zinc alloy material and preparation method thereof |
| US11351290B1 (en) | 2020-04-08 | 2022-06-07 | Admtech, Llc | Absorbable high-strength zinc alloy for medical implants |
| CN112899527A (en) * | 2021-01-20 | 2021-06-04 | 湖南华锐科技集团股份有限公司 | Degradable zinc alloy bar and preparation method thereof |
| CN112899527B (en) * | 2021-01-20 | 2022-04-08 | 湖南华锐科技集团股份有限公司 | Degradable zinc alloy bar and preparation method thereof |
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| Publication number | Publication date |
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| WO2016145958A1 (en) | 2016-09-22 |
| CN104651665B (en) | 2017-11-03 |
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