CN104649944A - Methoxybenzenesulfonyl hydrazide type GPR119 agonist, as well as preparation method and application thereof - Google Patents
Methoxybenzenesulfonyl hydrazide type GPR119 agonist, as well as preparation method and application thereof Download PDFInfo
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- CN104649944A CN104649944A CN201510080419.7A CN201510080419A CN104649944A CN 104649944 A CN104649944 A CN 104649944A CN 201510080419 A CN201510080419 A CN 201510080419A CN 104649944 A CN104649944 A CN 104649944A
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- compound
- diabetes
- glp
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- 0 NNS1(*C1)c1ccccc1 Chemical compound NNS1(*C1)c1ccccc1 0.000 description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- SODWJACROGQSMM-UHFFFAOYSA-N Nc1c(CCCC2)c2ccc1 Chemical compound Nc1c(CCCC2)c2ccc1 SODWJACROGQSMM-UHFFFAOYSA-N 0.000 description 1
- HHKKJSNWJYYOBE-UHFFFAOYSA-N O=C(Nc(cc1)ccc1N=C=O)Nc1c(CCCC2)c2ccc1 Chemical compound O=C(Nc(cc1)ccc1N=C=O)Nc1c(CCCC2)c2ccc1 HHKKJSNWJYYOBE-UHFFFAOYSA-N 0.000 description 1
- ALQLPWJFHRMHIU-UHFFFAOYSA-N O=C=Nc(cc1)ccc1N=C=O Chemical compound O=C=Nc(cc1)ccc1N=C=O ALQLPWJFHRMHIU-UHFFFAOYSA-N 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Compound | EC 50(nM) |
Reference compound D-1 | 20.9 |
Compound I-1 | 4.7 |
Compound I-2 | 5.2 |
Compound I-3 | 5.8 |
Claims (4)
Priority Applications (1)
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CN201510080419.7A CN104649944B (en) | 2015-02-13 | 2015-02-13 | One class methoxy benzene sulfonyl hydrazine GPR119 agonist, preparation method and its usage |
Applications Claiming Priority (1)
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CN201510080419.7A CN104649944B (en) | 2015-02-13 | 2015-02-13 | One class methoxy benzene sulfonyl hydrazine GPR119 agonist, preparation method and its usage |
Publications (2)
Publication Number | Publication Date |
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CN104649944A true CN104649944A (en) | 2015-05-27 |
CN104649944B CN104649944B (en) | 2016-08-31 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201510080419.7A Active CN104649944B (en) | 2015-02-13 | 2015-02-13 | One class methoxy benzene sulfonyl hydrazine GPR119 agonist, preparation method and its usage |
Country Status (1)
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CN (1) | CN104649944B (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08238852A (en) * | 1995-03-06 | 1996-09-17 | Nippon Paper Ind Co Ltd | Thermal recording sheet |
EP1314723A1 (en) * | 2001-11-27 | 2003-05-28 | Warner-Lambert Company | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases |
CN102397257A (en) * | 2010-09-17 | 2012-04-04 | 北京化工大学 | Preparation process for ultrafine glibenclamide particles |
CN103159651A (en) * | 2011-12-14 | 2013-06-19 | 安徽贝克联合制药有限公司 | Sulfonylurea guanidine and preparation method and application thereof |
-
2015
- 2015-02-13 CN CN201510080419.7A patent/CN104649944B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08238852A (en) * | 1995-03-06 | 1996-09-17 | Nippon Paper Ind Co Ltd | Thermal recording sheet |
EP1314723A1 (en) * | 2001-11-27 | 2003-05-28 | Warner-Lambert Company | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases |
CN102397257A (en) * | 2010-09-17 | 2012-04-04 | 北京化工大学 | Preparation process for ultrafine glibenclamide particles |
CN103159651A (en) * | 2011-12-14 | 2013-06-19 | 安徽贝克联合制药有限公司 | Sulfonylurea guanidine and preparation method and application thereof |
Non-Patent Citations (2)
Title |
---|
FARNOUSH FARIDBOD ET AL: "Multi-walled carbon nanotubes (MWCNTs) and room temperature ionic liquids (RTILs) carbon paste Er(III) sensor based on a new derivative of dansyl chloride", 《ELECTROCHIMICA ACTA》, vol. 55, 31 December 2009 (2009-12-31), XP026670118, DOI: doi:10.1016/j.electacta.2009.08.044 * |
李鹏飞等: "4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征", 《有机化学》, vol. 25, no. 9, 31 December 2005 (2005-12-31) * |
Also Published As
Publication number | Publication date |
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CN104649944B (en) | 2016-08-31 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Methoxybenzenesulfonyl hydrazide type GPR119 agonist, as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160831 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Date of cancellation: 20190604 Granted publication date: 20160831 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
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Effective date of registration: 20190805 Address after: 233000 Yuhui District, Bengbu City, Anhui Province, No. 1750 Shengli West Road, No. 316 Pioneering Building, Huineng Small and Micro Enterprise Pioneering Center Patentee after: Bengbu Dingrong Science and Technology Information Consulting Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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