CN104648834A - Protecting device of freeze-drying excipient containing skeleton support agent and binder and preparation method thereof - Google Patents
Protecting device of freeze-drying excipient containing skeleton support agent and binder and preparation method thereof Download PDFInfo
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- CN104648834A CN104648834A CN201310587249.2A CN201310587249A CN104648834A CN 104648834 A CN104648834 A CN 104648834A CN 201310587249 A CN201310587249 A CN 201310587249A CN 104648834 A CN104648834 A CN 104648834A
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- drying excipient
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- fender guard
- drying
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
Abstract
The invention relates to a protecting device of a freeze-drying excipient and a preparation method thereof, in particular relates to a freeze-drying excipient containing skeleton support agent and binder and a protecting device of the freeze-drying excipient, and aims at essentially solving the defects of low hardness, easy breaking, manual moving out to lead to secondary pollution and other of the traditional freeze-drying excipient, decreasing the preparation cost, increasing the yield, reducing the packing cost as well as realizing automatic production.
Description
Technical field
The present invention relates to a kind of freeze-drying excipient preparation fender guard and preparation method thereof, particularly a kind of fender guard containing the freeze-drying excipient preparation of skeleton supporting agent and adhesive agent composition, and its corresponding preparation method.
Background technology
Freeze-drying excipient technology refers to and add skeleton supporting agent and adhesive agent in the active component of flowable liquid, semisolid or solid, or itself contains adhesive agent and skeleton supporting agent in described flowable liquid, semisolid or solid, then be filled in forming mould, be able to shaping technology by freeze drying process, the preparation prepared by freeze-drying excipient technology is called freeze-drying excipient preparation.
Because such preparation adopts freeze drying process; thermally sensitive composition can be protected not to be destroyed; produce a large amount of micropore and duct by water sublimed simultaneously; very fast disintegration and dissolution velocity can be had; therefore receive widespread use, multiple fields such as oral disnitegration tablet, fast-release tablet, chewable tablets, special cosmetics can be applied to.
, there is the shortcomings such as the strong but hardness of complex manufacturing, high, the easy moisture absorption of cost, toughness is low in traditional freeze-drying excipient preparation (see Chinese patent CN200580013010.8).
Contriver dedicates itself to innovation; there is provided a kind of containing skeleton supporting agent and the freeze-drying excipient preparation of adhesive agent and the fender guard of freeze-drying excipient preparation; inherently solve low, the easy fragmentation of above-mentioned traditional freeze-drying excipient preparation hardness, need staff taking-up to cause the preparation defects such as secondary pollution; both preparation cost can be reduced; improve yield rate; can also packing cost be reduced, realize automated production.
Summary of the invention
The invention provides a kind of fender guard and the preparation method that contain the freeze-drying excipient preparation of skeleton supporting agent and adhesive agent composition.
The fender guard of described freeze-drying excipient preparation is the cavity of a two ends Ji mouth, comprises feed end (1), freeze-drying excipient preparation (2), discharge end (3) three part.
The feed end (1) of described fender guard, can be connected with the port of various adapter, connection mode includes but not limited to the various fixed forms that can dismantle after a procedure such as plug-in type, screw-type, clamping hoop type, and the port of shape and size chi and adapter adapts;
The discharge end (3) of described fender guard can be the discharging opening of any form, include but not limited to straight pipe type, suction pipe shape, dropper shape, ball shape, spray first-class;
Freeze-drying excipient preparation (2) in described fender guard, primarily of active component and matrix composition.
The main component of described matrix is adhesive agent and skeleton supporting agent.
The weight proportion of described matrix is adhesive agent: skeleton supporting agent=1:100 to 100:1.Can more preferably 1:50 to 50:1,1:30 to 30:1,1:25 to 25:1,1:20 to 20:1,1:15 to 15:1,1:10 to 10:1,1:5 to 5:1,1:3 to 3:1, wherein most preferably 1:25 to 25:1,1:5 to 5:1,1:3 to 3:1.
Described adhesive agent is edible or pharmaceutically useful a kind of water-soluble high-molecular material, can be polysaccharide, polypeptide, protein, also may be synthetic polymeric's Polymer, or through the natural macromolecular material of remodeling or its compound.Conventional adhesive agent includes but not limited to glue class (collagen, gelatin, gelatin hydrolysate, Arabic gum, xanthans, carragheen, pectin, konjac glucomannan, carrageenan, locust bean gum, natural gum, locust bean gum etc.), cellulose ethers (carboxymethyl cellulose, carboxyethyl cellulose, HEMC, hydroxypropyl methylcellulose etc.), modified starch series (pulullan, hydroxypropul starch etc., see R.P.Scherer US4305502A), PVP, PVA, hyalomitome acids, albumin, shitosan, dextran, agar, polyaminoacid, glucan and their combination etc. thereof, polyaminoacid (polyglutamic acid, polyalanine, polylysine etc.), glycan (fucoidin, synanthrin, glucan) etc.
Described skeleton supporting agent comprises the material such as amino acid (as amino acetic acid, alanine, glutamic acid etc.) and inorganic salts (as sodium phosphate, aluminium silicate etc.) being not limited to sugar (as maltose, trehalose etc.), sugar alcohol (as sweet mellow wine, sorbierite), 2-12 carbon atom.
Described active component can be water-soluble also can be water-fast material, and described active component can be selected from one or more the combination in chemicals composition, traditional Chinese medicine ingredients, natural extract, bioactive ingredients, skin nursing beneficiating ingredient.
There is no particular limitation for active component involved in the present invention, can be selected from but be not limited to the composite of one or more compositions following.
Chemicals (active constituents of medicine):
Antipyretic-antalgic anti-inflammatory agent, such as aspirin, Diflunisal, salsalate, paracetamol, Indomethacin, brufen, naproxen, Ketoprofen, pirprofen, suprofen, Flurbiprofen, piroxicam, Meloxicam, aulin, Benzbromarone etc.;
Central stimulant, such as pemoline, adrafinil, Piracetam etc.;
Treatment migraine agent, such as Sumatriptan succinate;
Antalgesic, such as rotundin, buprenorphine, pentazocine, naloxone etc.;
Anti-parkinson profit treatment senile dementia medicine, such as levodopa, compound carbidopa, compound benserazide, amantadine hydrochloride, piribedil, general sieve phenol amine, donepezil, huperzine are first-class;
Psychotolytic, such as chlorpromazine, fenazil, pethidine, thioridazine, Chlorprothixene, Clozapine, Sulpiride, Tai Bili, penfluridol, Risperidone etc.;
Antiepileptic and anticonvulsive drug, such as dilantin sodium, carbamazepine, Primidone, Gabapentin, Lamotrigine, sodium vedproate, Clonazepam etc.Hypnotic sedative agent, such as diazepam, nitrazepam, Oxazepam, Lorazepam, phenobarbital etc.;
Cholinesterase inhibitor, such as hyoscine etc.;
Antiarrhymic, such as the third pyridine, tocainide, mexiletine, aetmozine, dilantin sodium, Propafenone, amiodarone etc.;
Antianginal and antiatherosclerotic, such as Propranolol, nifedipine, Gemfibrozil, Bezafibrate, Lovastatin, Simvastatin, Pravastatin etc.;
Antihypertensive, such as Enalapril, captopril, Hydrochioro, Amlodipine etc.;
Adrenoceptor blocking agents, such as acebutolol, alprenolol etc.;
Corticosteroid medicine, such as betamethasone, cortisone acetate etc.;
Antidiabetic, such as Repaglinide etc.;
Antithyroid drug, such as propylthiouracil (PTU), Carbimazole, methimazole etc.;
Antithistamine, such as Cetirizine Hydrochloride, Loratadine etc.;
Autacoid, such as dinoprostone, Alprostadil, Betahistine etc.;
Digestive system surgical procedures, such as scopolamine butylbromide, Granisetron Hydrochloride etc.;
Hematological system medicine, such as EPO, cobamamide etc.;
Urinary system medicine, such as azosemide, frusemide etc.;
Reproductive system medicine, such as estrogen, Nandrolone Phenylpropionate etc.;
Antiparasitic agent, such as albendazole, cambendazole etc.;
Antineoplastic, such as aminoglutethimide, amsacrine etc.;
Antimicrobial, such as ampicillin, sulbenicillin disodium etc.;
Tri-Biocin, such as Amoxicillin, cefalexin, Cefprozil, CEFUROXIME AXETIL, Roxithromycin, Erythromycin Ethylsuccinate, josamycin etc.
Traditional Chinese medicine ingredients:
Effective Component of Chinese Medicine monomer, as: Breviscapinun, qinghaosu, huperzine, tetrahydropalmatine etc.;
Single medicinal material material extract and compound Chinese medicine extract, as: tanshinone extract, salvianolic acid extract, composite salvia dropping extract of bolus, cow-bezoar bolus compound extract, ginseng stem and leave general saponin, asiatic moonseed extract, general ginsenoside, American ginseng total saponins, Breviscapinun, Glabrous Sarcandra Herb medicinal extract, arasaponin, capillary extract, extractum rhei, andrographolide, hawthorne leaf P.E, asiaticoside, ginkgo biloba p.e etc.Natural plant extracts: as aloe extract, yam extract, Bilberry fruit P.E, Bitter Melon P.E, Echinacea Purpurea Herb P.E, Feverfew P.E, mangosteen extract, pine needle and Pine Bark, Brazilian blackberry extract, mulberries extract, elder berry extract, Cranberry extract, astaxanthin, lycopene, green-tea extract, grape pip and grape skin extract, glabridin, Paeoniflorin, licoflavone, Cortex Moutan extract etc.Bioactive ingredients: EGF, bFGF, aFGF, KGF, IGF, NGF, TGF, HGH etc.
Nutritious supplementary pharmaceutical, skin nursing beneficiating ingredient: vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, coenzyme class, proteinase, metallothionein, pearl and hydrolyzate, cow's milk and extract thereof, pollen and extract, royal jelly, propolis etc.
Described freeze-drying excipient preparation, needs to add antioxidant, flavouring and essence, skin penetration enhancer, pH adjusting agent etc. according to preparation process.
Described antioxidant includes but not limited to the compound of one or several in the polyhydric phenols of vitamin C and derivant thereof, anthocyanidin, resveratrol, plant origin;
Described flavouring and essence include but not limited to the compound of mint flavored, chocolate flavoured, the essence such as fruity, vanilla flavored, caf, tea flavour, corn taste, lemon, milk flavor or more one or more fragrance;
Described skin penetration enhancer includes but not limited to the compound of any one or several in lecithin, saponin(e, bay alkyd sodium, azone, tween, sapn;
Described pH adjusting agent includes but not limited to any one in citric acid, tartaric acid, carbonate, sodium carbonate, phosphate or several compound.
Described freeze-drying excipient preparation (2) can be the freeze-drying excipient preparation that arbitrary shape and size and fender guard cavity adapt; fender guard cavity can arrange the devices such as projection, screw thread or sieve plate at inside face, further to ensure that freeze-drying excipient preparation can not come off or skid off in preparation and course of normal operation from fender guard.
Described fender guard can adopt any material to make as required, includes but not limited to plastics, rubber, metal, glass, composite material etc.
The invention still further relates to the method preparing above-mentioned freeze-drying excipient preparation, the method comprises assembling method after original position desivac and freeze-drying.
I. original position desivac:
A () will include but not limited to that the solution that active component, water, adhesive agent, skeleton supporting agent and other auxiliaries are formed or suspension inject fender guard cavity; Or solid constituent (can comprise active component, adhesive agent and other auxiliary materials) is injected fender guard cavity, then add water and be made into suspension;
B solution that (a) obtains by () or suspension carry out degassed in fender guard;
(c) (b) is obtained degassed after suspension or without degassed direct that (a) is freezing at low temperatures;
D preparation that (c) obtains by () carries out lyophilisation in fender guard, obtains freeze-drying excipient preparation.
II. assembling method after freeze-drying:
A () will include but not limited to the solution that active component, water, adhesive agent, skeleton supporting agent and other auxiliaries are formed or suspension injection moulding mould; Or by solid constituent (active component, adhesive agent and other auxiliary materials can be comprised) injection moulding mould, then add water and be made into suspension;
B solution that (a) obtains by () or suspension carry out degassed in forming mould;
(c) (b) is obtained degassed after suspension or without degassed direct that (a) is freezing at low temperatures;
D preparation that (c) obtains by () carries out lyophilisation in forming mould, obtains freeze-drying excipient preparation;
E freeze-drying excipient preparation that (d) obtains by () is detached into mould, is fitted in fender guard cavity.
In above-mentioned preparation method, wherein Liquid Injection can adopt the liquid-transfering devices such as accurate quantification pipet, liquid-transfering gun, electronic liquor-transferring rifle, also plunger pump, gear type pump, peristaltic pump etc. can be adopted, the solution configured, suspension or suspending fluid are injected quantitative forming mould, and solid injection molding can adopt accurate solid measurer, vibrations capillary tub flow of powder controller;
Wherein degas method can adopt centrifugal degassing method, vacuum degasification method and ultrasonic degas method etc.;
The wherein freezing mode that can adopt liquid nitrogen or liquid, dry ice spray refrigeration or sleeve pipe cooling back installation, turbine expander refrigeration mode or cascade refrigeration mode, at-20 DEG C--at 196 DEG C of temperature, become solid by freezing to solution, suspension or suspending fluid rapidly;
Wherein freeze-drying adopts the degree of vacuum of 0.01-20 millibar, temperature freeze-drying between-70 DEG C to 50 DEG C scopes;
In use; after feed end (1) in fender guard is connected with the adapter port containing liquid; liquid can pass through feed end (1) and enter in fender guard cavity and mix with freeze-drying excipient preparation (2), then flows out from discharge end (3).
Accompanying drawing explanation
Fig. 1 is the structural representation of freeze-drying excipient preparation fender guard;
Detailed description of the invention
Further illustrate the present invention by the following examples, but the present invention is not restricted to this.
Embodiment 1:
Pearl powder: sweet mellow wine: hyaluronic acid=1:2:100; hyaluronic acid 100mg; after wherein 90mg hyaluronic acid mixes with 1mg pearl fine powder and 2mg sweet mellow wine; accurately fillingly enter in 0.5ml mould, 10mg hyaluronic acid, after the water-soluble solution of 0.3ml, pours into in the mould containing 90mg hyaluronic acid and 1mg pearl powder; stirring makes aqueous dispersion in powder; quick-frozen is to-20 degrees Celsius, and freeze-drying becomes skin care solid elite, loads in fender guard.
During use, take out freeze-drying excipient preparation fender guard, inserted in by coupling end on hair conditioner extrusion, promote to extrude pump head, hair conditioner enters fender guard through feed end, extrudes, become novel hair products with freeze-drying excipient preparation after fully mixing from discharge end.
Embodiment 2:
EGF stoste; gelatin, gelatin hydrolysate and sweet mellow wine is added after thawing; be mixed with containing the EGF (weight ratio) of 5/100000ths, the gelatin+gelatin hydrolysate solution containing 5%, fillingly enter 0.1 milliliter of forming mould, in the shaping rear loading fender guard cavity of freeze-drying.
During use; take out freeze-drying excipient preparation fender guard; by the Essence bottle mouth position of feed end access band Pressing pump; pressing pump head makes Essence enter freeze-drying excipient preparation fender guard cavity from feed end; after water fully mixes with freeze-drying excipient preparation; again mixed liquor is extruded use from discharge end, become modern biotechnology cosmetics.
Embodiment 3:
Royal jelly: trehalose: PVP=2:1:1, is mixed with solution, is fed in the fender guard cavity with fog-spray nozzle, and in cavity, quick-frozen is to after-100 degrees Celsius, freeze-drying in position.Potable water is sucked in advance in syringe during use; afterwards freeze-drying excipient preparation fender guard is connected on syringe outlet position; when the potable water in syringe is extruded from outlet; freeze-drying excipient preparation fender guard cavity is entered by feed end; be thoroughly mixed to form containing drug solns with freeze-drying excipient preparation; spray in oral cavity by the fog-spray nozzle of discharge end afterwards, form mouth spray type medicine.
Fender guard structure of the present invention is not limited to form cited in embodiment, and embodiment is only preferred embodiment of the present invention, can not limit protection domain with this.All with the simple or equivalent change described in right of the present invention and modification, all belong to protection scope of the present invention.
Claims (13)
1. contain a freeze-drying excipient preparation fender guard for skeleton supporting agent and adhesive agent, be the cavity of a both ends open, comprise feed end (1), freeze-drying excipient preparation (2), discharge end (3) three part.
2. freeze-drying excipient preparation fender guard as claimed in claim 1, it is characterized in that feed end (1) can be connected with the port of various adapter, connection mode includes but not limited to the various fixed forms that can dismantle after a procedure such as plug-in type, screw-type, clamping hoop type, and the port of shape and size dimension and adapter adapts; Discharge end (3) can be the discharging opening of any form, include but not limited to straight pipe type, suction pipe shape, dropper shape, ball shape, spray first-class.
3. freeze-drying excipient preparation fender guard as claimed in claim 1; it is characterized in that the cavity inner surface of fender guard can arrange the devices such as projection, screw thread or sieve plate further, to ensure that freeze-drying excipient preparation can not come off or skid off in manufacture, packaging, transport and use procedure from fender guard.
4. freeze-drying excipient preparation fender guard as claimed in claim 1, is characterized in that the material of this fender guard can adopt any material to make as required, includes but not limited to plastics, rubber, metal, glass, composite material etc.
5. freeze-drying excipient preparation as claimed in claim 1, it is characterized in that this freeze-drying excipient preparation is primarily of active component and matrix composition, the main component of its mesostroma is adhesive agent and skeleton supporting agent, and the weight proportion of matrix is adhesive agent: skeleton supporting agent=1:100 to 100:1.
6. freeze-drying excipient preparation as claimed in claim 5, is characterized in that described active component is selected from one or more the combination in chemicals composition, traditional Chinese medicine ingredients, natural extract, bioactive ingredients, nutrition fortifier, skin nursing beneficiating ingredient.
7. freeze-drying excipient preparation as claimed in claim 5, is characterized in that described adhesive agent is glue class, cellulose ethers, modified starch series, PVP, carbomer, PVA, hyalomitome acids, albumin, shitosan, dextran, agar, polyaminoacid, glycan or their combination.
8. freeze-drying excipient preparation according to claim 7, is characterized in that described glue class adhesive agent is collagen, gelatin, gelatin hydrolysate, Arabic gum, xanthans, carragheen, pectin, konjac glucomannan, carrageenan, locust bean gum, natural gum, locust bean gum; Described cellulose ethers adhesive agent is carboxymethyl cellulose, carboxyethyl cellulose, HEMC, hydroxypropyl methylcellulose; Described modified starch series adhesive agent is selected from pulullan, hydroxypropul starch, hydroxypropyl methyl starch, pregelatinized starch, amylose, CMS, HES, hydroxypropul starch etc.; Described polyaminoacid is selected from polyglutamic acid, polyalanine, polylysine etc.; Affiliated glycan is selected from fucoidin, synanthrin, glucan etc.
9. freeze-drying excipient preparation as claimed in claim 5, is characterized in that this skeleton supporting agent contained by freeze-drying excipient preparation comprises materials such as being not limited to sugar (as maltose, trehalose etc.), sugar alcohol (as sweet mellow wine, sorbierite), the amino acid (as amino acetic acid, alanine, glutamic acid etc.) of 2-12 carbon atom and inorganic salts (as sodium phosphate, aluminium silicate etc.);
10. freeze-drying excipient preparation as claimed in claim 5, is characterized in that wherein also containing other auxiliary material, and other stone described is one or more in antioxidant, flavouring and essence, skin penetration enhancer, PH conditioning agent.
11. freeze-drying excipient preparations as claimed in claim 9, is characterized in that described antioxidant is selected from the compound of one or several in the polyhydric phenols of vitamin C, anthocyanidin, resveratrol, plant origin; Described flavouring and essence are selected from the compound of one or more fragrance of mint flavored, chocolate flavoured, the essence such as vanilla flavored, caf, tea flavour, corn taste, lemon, milk flavor or more; Described skin penetration enhancer is selected from the compound of any one or several in lecithin, tween, sapn; Described PH conditioning agent is selected from any one in citric acid, tartaric acid, sodium bicarbonate, sodium carbonate or several compound.
The preparation method of 12. freeze-drying excipient preparations as claimed in claim 5, is characterized in that this preparation method is divided into assembling method two kinds of methods after original position desivac and freeze-drying:
I. original position desivac:
A () will include but not limited to that the solution that active component, water, adhesive agent, skeleton supporting agent and other auxiliaries are formed or suspension inject fender guard cavity; Or solid constituent (can comprise active component, adhesive agent and other auxiliary materials) is injected fender guard cavity, then add water and be made into suspension;
B solution that (a) obtains by () or suspension carry out degassed in fender guard;
(c) (b) is obtained degassed after suspension or without degassed direct that (a) is freezing at low temperatures;
D preparation that (c) obtains by () carries out lyophilisation in fender guard, obtains freeze-drying excipient preparation.
II. assembling method after freeze-drying:
A () will include but not limited to the solution that active component, water, adhesive agent, skeleton supporting agent and other auxiliaries are formed or suspension injection moulding mould; Or by solid constituent (active component, adhesive agent and other auxiliary materials can be comprised) injection moulding mould, then add water and be made into suspension;
B solution that (a) obtains by () or suspension carry out degassed in forming mould;
(c) (b) is obtained degassed after suspension or without degassed direct that (a) is freezing at low temperatures;
D preparation that (c) obtains by () carries out lyophilisation in forming mould, obtains freeze-drying excipient preparation;
E freeze-drying excipient preparation that (d) obtains by () is detached into mould, is fitted in fender guard cavity.
13. freeze-drying excipient preparation fender guards as claimed in claim 1; it is characterized in that this fender guard in use; after feed end (1) in fender guard is connected with the adapter port containing liquid; liquid can pass through feed end (1) and enter in fender guard cavity and mix with freeze-drying excipient preparation (2), then flows out from discharge end (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310587249.2A CN104648834A (en) | 2013-11-21 | 2013-11-21 | Protecting device of freeze-drying excipient containing skeleton support agent and binder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310587249.2A CN104648834A (en) | 2013-11-21 | 2013-11-21 | Protecting device of freeze-drying excipient containing skeleton support agent and binder and preparation method thereof |
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| Publication Number | Publication Date |
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| CN104648834A true CN104648834A (en) | 2015-05-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310587249.2A Pending CN104648834A (en) | 2013-11-21 | 2013-11-21 | Protecting device of freeze-drying excipient containing skeleton support agent and binder and preparation method thereof |
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| CN (1) | CN104648834A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468528A (en) * | 2016-06-07 | 2017-12-15 | 董玲 | A kind of lyophilized formulations and preparation method thereof |
| CN111773188A (en) * | 2020-08-06 | 2020-10-16 | 武汉人福药业有限责任公司 | Preparation method of urokinase freeze-dried powder |
| CN114568708A (en) * | 2020-11-30 | 2022-06-03 | 河北菲瑞生物技术有限公司 | Lactoferrin preparation and preparation method thereof |
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| CN1089829A (en) * | 1992-12-01 | 1994-07-27 | R·P·谢勒有限公司 | Be used to be manufactured on the improved method of the lyophilization medicament in the protruding blister pack of multilamellar |
| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
| CN103318551A (en) * | 2013-06-24 | 2013-09-25 | 李和伟 | System for packaging and delivering freeze-dried excipient and preparation method of freeze-dried excipient |
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2013
- 2013-11-21 CN CN201310587249.2A patent/CN104648834A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089829A (en) * | 1992-12-01 | 1994-07-27 | R·P·谢勒有限公司 | Be used to be manufactured on the improved method of the lyophilization medicament in the protruding blister pack of multilamellar |
| CN1689649A (en) * | 2004-04-30 | 2005-11-02 | 量子高科（北京）研究院有限公司 | Oral cavity quick dissolving preparation and production method thereof |
| CN103318551A (en) * | 2013-06-24 | 2013-09-25 | 李和伟 | System for packaging and delivering freeze-dried excipient and preparation method of freeze-dried excipient |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468528A (en) * | 2016-06-07 | 2017-12-15 | 董玲 | A kind of lyophilized formulations and preparation method thereof |
| CN111773188A (en) * | 2020-08-06 | 2020-10-16 | 武汉人福药业有限责任公司 | Preparation method of urokinase freeze-dried powder |
| CN111773188B (en) * | 2020-08-06 | 2022-05-20 | 武汉人福药业有限责任公司 | Preparation method of urokinase freeze-dried powder |
| CN114568708A (en) * | 2020-11-30 | 2022-06-03 | 河北菲瑞生物技术有限公司 | Lactoferrin preparation and preparation method thereof |
| CN114568708B (en) * | 2020-11-30 | 2023-12-12 | 湖北菲瑞生物药业有限公司 | Lactoferrin preparation and preparation method thereof |
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Application publication date: 20150527 |