CN104644785B - The red dredging collateral patch of a kind of hydrophilic polymer gel layer and its river obtained - Google Patents
The red dredging collateral patch of a kind of hydrophilic polymer gel layer and its river obtained Download PDFInfo
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- CN104644785B CN104644785B CN201510056322.2A CN201510056322A CN104644785B CN 104644785 B CN104644785 B CN 104644785B CN 201510056322 A CN201510056322 A CN 201510056322A CN 104644785 B CN104644785 B CN 104644785B
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Abstract
The invention discloses the red dredging collateral patches of a kind of hydrophilic polymer gel layer and its river obtained.Hydrophilic polymer gel layer is contains safflower, Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens and the hydrophilic polymer gel of peppermint.It is pasted using the red dredging collateral in river a kind of made from hydrophilic polymer gel layer; including heating bag, fixed bed, nonadherent protective layer and the hydrophilic polymer gel layer; the fixed bed is fixed with heating bag on one side; another side is coated with hydrophilic polymer gel layer, covered with nonadherent protective layer on hydrophilic polymer gel layer.The red dredging collateral patch good permeability in river of the present invention, without sensitization, irritation, using easy, comfortable, there is stasis-dispelling and pain-killing, expand blood vessel, increase blood flow, the effect of improving microcirculation and inhibiting platelet aggregation and prevention infection, the situation effect for occurring scar, scleroma, spasm, breakage, vascellum endometrial hyperplasia, tenderness or strip scleroma especially for skin at internal arteriovenous fistula can be more preferable.
Description
Technical field
The invention belongs to medical medicine technical fields, and in particular to a kind of hydrophilic polymer gel layer and its river obtained
Red dredging collateral patch.
Background technology
Internal arteriovenous fistula (Arterio-venous Fistula, AVF) be current hemodialysis patients it is most preferable, using most
A kind of extensive permanent vascular access, dialysis patient carry out weekly 3 to 4 punctures, unavoidably cause patient vessel's inner membrance
Damage, leads to the complication such as Fistuk stenosis, thrombosis, false aneurysm, pain, bleeding, hemotoncus and infection, and internal fistula is risen
Promoting blood circulation and removing blood stasis, the processing of swelling and pain relieving effect has the measures such as Hirudoid smearing, potato slice external application, but these schemes must be avoided
Puncture needle mouth, preventive measure of protection when being only capable of as patient vessel without being damaged or being formed without clear scar, once occur
Cicatrix of skin, scleroma, spasm, vascellum endometrial hyperplasia, tenderness, strip scleroma are just difficult to maintain AVF's when severe complications
Function.
The pungent scattered temperature of Rhizoma Chuanxiong is logical, function promoting blood circulation, and effect is extensive, can extension body suitable for the illness of various stagnation of blood stasis
The platelet aggregation time of outer ADP inductions, there is depolymerisation to the blood platelet assembled.Safflower acrid flavour, it is warm-natured.The thoughts of returning home, Liver Channel.
Has the effect of invigorate blood circulation, removing blood stasis and analgesics.《Collected statements on the herbal foundation》：Safflower, blood-breaking, promoting circulation of blood and blood, the medicine for adjusting blood.Peppermint has alleviation
Pain, antisepsis and sterilization and other effects.Radix paeoniae rubrathe clearing heat and cooling blood, removing blood stasis and analgesics.《Newly organized traditional Chinese medicine summary》It is clearing heat and detoxicating to record ilex pubescens,
Blood circulation and channel invigorating, swelling and pain relieving expand blood vessel, release vasopasm, promote blood circulation, antibacterial anti-inflammatory.And these drugs how
It can act at internal arteriovenous fistula, it is current urgent problem to be solved to be preferably absorbed by the body.
Invention content
The present invention overcomes a kind of dredging collateral patch the defects of the prior art, is provided, hydrophilic polymer gel is immersed in
Safflower, Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens, peppermint extracting solution in, manufactured external use plaster, using aquagel to drug
Slow releasing function realizes the sustained release of drug, while patch good permeability of the present invention, no sensitization, stimulation good to skin adherence
Property.Zhi Jie Stickers are applied at internal arteriovenous fistula during use, using easy, comfortable, had stasis-dispelling and pain-killing, are expanded blood vessel, increase blood flow,
The effect of improving microcirculation and inhibiting platelet aggregation and prevention infection, there is scar especially for skin at internal arteriovenous fistula
Trace, scleroma, spasm, breakage, vascellum endometrial hyperplasia, the situation effect of tenderness or strip scleroma are more preferable.
It is existing it is defervescence plaster used be that body local amount of heat is walked by the vaporization zone of moisture in gel, play the work of cooling
With；Inventor promotes the performance of efficacy of drugs, those skilled in the art are universal the study found that during using aquagel
Think that chitosan has the function of to promote blood clotting, there is hemostatic function, and the drug of the present invention is blood vessel to be expanded, and is increased
Blood flow improves microcirculation and inhibits platelet aggregation, therefore aquagel is used as that during pharmaceutical carrier drug can be influenced
Promoting blood circulation effect, but the study found that the slow releasing function of aquagel promotes the performance of efficacy of drugs.
The object of the invention is achieved through the following technical solutions：
A kind of hydrophilic polymer gel layer, to contain safflower, Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens and the hydrophily of peppermint high score
Sub- gel.
The preferably hydrophilic polymer gel of the invention is aquagel.
The present invention also provides a kind of preparation methods of hydrophilic polymer gel layer.Specifically include following steps：
(1) after the radix paeoniae rubrathe is fried, cooling is for use；Rhizoma Chuanxiong shave solarization 2 days or more, then in 40 DEG C~45 DEG C drying, for use；
(2) radix paeoniae rubrathe, Rhizoma Chuanxiong, safflower, ilex pubescens and peppermint are impregnated two weeks or more in white wine, wherein, the radix paeoniae rubrathe, Rhizoma Chuanxiong,
Safflower, ilex pubescens and the mass ratio of peppermint are (5~10):(5~10):(5~10):(5~10):(0.5~1), the radix paeoniae rubrathe is white
Mass volume ratio in wine is 1:(15~30) g/ml；
(3) clear liquid is filtered to take；
(4) hydrophilic polymer gel is placed in clear liquid and impregnated, taken out up to hydrophilic polymer gel layer.
It is preferred that soaking time of the hydrophilic polymer gel in clear liquid is 4~6h；The volume of ethyl alcohol point in white wine
Number is 60%~70%.
A kind of preferred embodiment, the hydrophilic polymer gel are aquagel.
Another goal of the invention of the present invention is to provide a kind of red dredging collateral patch in river, including heating bag, fixed bed and anti-stick protection
Layer, further includes the hydrophilic polymer gel layer, and the heating bag is fixed on the upper surface of fixed bed, the following table of fixed bed
Face is coated with hydrophilic polymer gel layer, covered with nonadherent protective layer on hydrophilic polymer gel layer.
It is using modes such as stickup, sewings that the heating bag, which is fixed on above fixed bed, is preferably pasted.
It is preferred that the fixed bed sticks band for pharmaceutical grade non-woven fabrics, medical absorbent cotton/gauze or medical Elastic Cloth.
It is preferred that the nonadherent protective layer is medical embossing plastic film.
The heating bag includes the exothermic material in outer packing, inner bag and inner bag, and the exothermic material is iron powder, lemon
Acid, wood powder, activated carbon and water, mass ratio are：16:3:4.5:1:2.Using iron powder micro- electricity is formed in the case where acidity moistens Oxygen Condition
Pond aoxidizes, and discharges thermal energy；Citric acid is solid edible acid, and property is stablized, and soluble easily in water, acidity is suitable；Wood powder, activated carbon hole
It is more, acid solution can be adsorbed and maintain certain humidity, and make system always in loose condition (of surface), with control heating temp with it is lasting when
Between, activated carbon can make oxidation reaction continue to carry out as the anode of micro cell, and up to iron powder, the reaction was complete；Inner bag using multilayer without
Woven fabric is made, and has certain gas permeability and thermal conductivity, can control the height of heating temp and the length of duration, to avoid
The occurrence of low temperature, scald, outer packing using isolation air polybag, the production method of heating bag of the present invention be by
Various composition uniformly mixes, and puts into inner bag, then the inner bag equipped with exothermic material is fitted into outer packing, completely cuts off air.During use
Outer packing need to be only torn, inner bag is taken out and gently rubs, you can heat production.
Exothermic material can also add in aluminium powder and carbon dust.Exothermic material can be 20-60 parts of the reduced iron powder of 200 mesh, 100
5-20 parts of purpose activated carbon, 2-7 parts of sodium chloride, 1-5 parts of aluminium powder.
The present invention is had the advantage that relative to the prior art and advantageous effect.
1st, it is easy to use, comfortable, it is willing to accept for internal arteriovenous fistula person；
2nd, Stickers is applied conveniently, totally, without sensitization；
3rd, drug can the outer ADP inductions of extension body the platelet aggregation time, have depolymerisation, medicine to the blood platelet assembled
In object can preferably penetrate to the skin, improve blood circulation, there is partly sterilised, sterilization, prevention infection, promoting blood circulation, detumescence
The effect of analgesic, blood circulation, and there is sterilizing ability, heating bag contributes to the absorption of active ingredient, increases blood circulation, has
Imitate the formation of pre- preventing thrombosis；
When the 4th, being pasted using the red dredging collateral in patch river, position applies position without limited , Stickers can be freely movable, makes patient comfort；
Description of the drawings
Fig. 1 is the present invention looks up structural representation of the red dredging collateral patch in river of the present invention.
Fig. 2 is the overlooking the structure diagram of the red dredging collateral patch in river of the present invention.
Specific embodiment
The following example is further explanation of the present invention, and the present invention is not limited in any way.
Embodiment 1
A kind of hydrophilic polymer gel layer is made in the present invention, to contain safflower, Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens and peppermint
Polyether-Chitosan Hydrogel.
Polyether-Chitosan Hydrogel of the present invention is to use Wu Guojie, Li Jinman, what Wang Fuhua was delivered《Polyethers-chitosan water
The research of gel swelling performance》In method be prepared.
As illustrated in fig. 1 and 2：It is pasted using a kind of dredging collateral made from a kind of hydrophilic polymer gel layer of the present invention, including adding
Hot bag 4, fixed bed 1 and nonadherent protective layer 3, further include hydrophilic polymer gel layer 2, and the heating bag 4 is pasted onto fixed bed 1
Upper surface, the lower surface of fixed bed 1 is coated with hydrophilic polymer gel layer 2, on hydrophilic polymer gel layer 2 covered with
Nonadherent protective layer 3.
The heating bag includes the exothermic material in outer packing, inner bag and inner bag.The exothermic material is iron powder, lemon
Acid, wood powder, activated carbon and water, mass ratio are：16:3:4.5:1:2.Inner bag is made of non-woven fabrics, and outer packing is empty using isolation
The polybag of gas.
The preparation method of the hydrophilic polymer gel layer 2 includes the following steps：
(1) radix paeoniae rubrathe tablet is taken to put stir-fry in pot has focus for degree to micro-, and taking-up cools completely, and pharmacological property relatively mitigation, living after the radix paeoniae rubrathe is fried
Blood and relieving pain is without in wound, available for the stagnant pain of the stasis of blood.The solarization of Rhizoma Chuanxiong shave is placed in baking oven for 2 days, and oven temperature is controlled 40
DEG C, it is stirred up and down during solarization and baking, to dry as early as possible.Then by the radix paeoniae rubrathe after stir-fry, the Rhizoma Chuanxiong after drying, safflower, hair
It is impregnated one month in the white wine that Chinese ilex and peppermint are 75% in volume fraction of ethanol, wherein, radix paeoniae rubrathe 100g, safflower 100g, Rhizoma Chuanxiong
100g, ilex pubescens 100g, peppermint 5g, white wine 2000ml；
(2) clear liquid is filtered to take；
(3) aquagel is placed in clear liquid and impregnates 4h, taken out up to hydrophilic polymer gel layer.
The fixed bed 1 sticks band for medical Elastic Cloth, and the nonadherent protective layer 3 is medical embossing plastic film.During use
Nonadherent protective layer 3 is thrown off, is covered in internal fistula swelling position with hydrophilic polymer gel layer 2, medical Elastic Cloth sticks band and sticks in
Skin other than swelling position plays the role of fixed.The heating bag 4 is pasted onto the upper surface of fixed bed 1, and heating bag helps
In the absorption of active ingredient, increase blood circulation, the formation of effective pre- preventing thrombosis.The swelling of patient's internal fistula uses this hair after 24 hours
The patch of bright embodiment 1, effect are as shown in table 1.
Reference examples 1
Hydrophilic polymer gel uses polyvinyl alcohol hydrogel, remaining is identical with the embodiment of the present invention 1.Same disease
People uses the patch effect comparison table of embodiment 1 and reference examples 1, as shown in table 1.
Reference examples 2
Hydrophilic polymer gel uses polyacrylamide gel, remaining is identical with the embodiment of the present invention 1.Same disease
People uses the patch effect comparison table of embodiment 1 and reference examples 2, as shown in table 1.
Table 1
Table 1 can obtain hydrophilic polymer gel using the effect of aquagel better than reference examples 1 and 2, reason
The slow releasing function that may be aquagel is better than remaining two kinds of hydrogel, and drug effect can be kept long-acting, promotes pharmic function
Performance.
Dredging collateral patch and the Hirudoid of the embodiment of the present invention 1 are smeared, and the Contrast on effect that potato slice is applied with is as shown in table 2.
Table 2
| Embodiment 1 | Hirudoid is smeared | Potato slice is applied with | |
| Patient Huang 52 years old | Swelling disappears after 40 hours | Swelling disappears after one week | Swelling disappears after fortnight |
Table 2 can show that hydrophilic polymer gel is smeared using the effect of aquagel better than Hirudoid, potato
Slice is applied with, and reason may be that safflower has the function of promoting blood circulation, dissolving stasis, detumescence, and Rhizoma Chuanxiong has the work(of blood-activating and qi-promoting wind-expelling pain-stopping
Effect, alcohol have the function of permeability by force and reduction surface tension, peppermint relieves pain, antisepsis and sterilization, and other effects.Their phases
Interaction promotes the performance of pharmic function.
Embodiment 2
A kind of hydrophilic polymer gel layer is made in the present invention, to contain safflower, Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens and peppermint
Aquagel.
As illustrated in fig. 1 and 2：It is pasted using a kind of dredging collateral made from a kind of hydrophilic polymer gel layer of the present invention, including adding
Hot bag 4, fixed bed 1 and nonadherent protective layer 3, further include hydrophilic polymer gel layer 2, and the heating bag 4 is pasted onto fixed bed 1
Upper surface, the lower surface of fixed bed 1 is coated with hydrophilic polymer gel layer 2, on hydrophilic polymer gel layer 2 covered with
Nonadherent protective layer 3.
The heating bag includes the exothermic material in outer packing, inner bag and inner bag.The exothermic material is iron powder, lemon
Acid, wood powder, activated carbon and water, mass ratio are：16:3:4.5:1:2.Inner bag is made of non-woven fabrics, and outer packing is empty using isolation
The polybag of gas.
The preparation method of the hydrophilic polymer gel layer 2 includes the following steps：
(1) radix paeoniae rubrathe tablet is taken to put stir-fry in pot has focus for degree to micro-, and taking-up cools completely, and pharmacological property relatively mitigation, living after the radix paeoniae rubrathe is fried
Blood and relieving pain is without in wound, available for the stagnant pain of the stasis of blood.The solarization of Rhizoma Chuanxiong shave is placed in baking oven for 2 days, and oven temperature is controlled 45
DEG C, it is stirred up and down during solarization and baking, to dry as early as possible.Then by the radix paeoniae rubrathe after stir-fry, the Rhizoma Chuanxiong after drying, safflower, hair
It is impregnated three weeks in the white wine that Chinese ilex and peppermint are 75% in volume fraction of ethanol, wherein, radix paeoniae rubrathe 50g, safflower 50g, Rhizoma Chuanxiong 50g,
Ilex pubescens 50g, peppermint 10g, white wine 750ml；
(2) clear liquid is filtered to take；
(3) aquagel is placed in clear liquid and impregnates 6h, taken out up to hydrophilic polymer gel layer.
The fixed bed 1 sticks band for medical Elastic Cloth, and the nonadherent protective layer 3 is medical embossing plastic film.During use
Nonadherent protective layer 3 is thrown off, is covered in internal fistula swelling position with hydrophilic polymer gel layer 2, medical Elastic Cloth sticks band and sticks in
Skin other than swelling position plays the role of fixed, and the heating bag 4 is pasted onto the upper surface of fixed bed 1, and heating bag helps
In the absorption of active ingredient, increase blood circulation, the formation of effective pre- preventing thrombosis.The swelling of patient's internal fistula uses this hair after 24 hours
The patch of bright embodiment 2, effect are as shown in table 3.
Reference examples 3
Hydrophilic polymer gel uses gelatin, remaining is identical with the embodiment of the present invention 2.Same patient uses implementation
The patch effect comparison table of example 2 and reference examples 3, as shown in table 3.
Reference examples 4
Hydrophilic polymer gel uses polyvinylpyrrolidone hydrogel, remaining is identical with the embodiment of the present invention 2.Together
The patient of sample uses the patch effect comparison table of embodiment 2 and reference examples 4, as shown in table 3.
Table 3
Table 3 can obtain hydrophilic polymer gel using the effect of aquagel better than reference examples 3 and 4, reason
The slow releasing function that may be aquagel is better than remaining two kinds of hydrogel, and drug effect can be kept long-acting, promotes pharmic function
Performance.
Embodiment 3
A kind of hydrophilic polymer gel layer is made in the present invention, to contain safflower, Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens and peppermint
Aquagel.
As illustrated in fig. 1 and 2：It is pasted using a kind of dredging collateral made from a kind of hydrophilic polymer gel layer of the present invention, including adding
Hot bag 4, fixed bed 1 and nonadherent protective layer 3, further include hydrophilic polymer gel layer 2, and the heating bag 4 is pasted onto fixed bed 1
Upper surface, the lower surface of fixed bed 1 is coated with hydrophilic polymer gel layer 2, on hydrophilic polymer gel layer 2 covered with
Nonadherent protective layer 3.
The heating bag includes the exothermic material in outer packing, inner bag and inner bag.It is added in the exothermic material
Aluminium powder and carbon dust.The exothermic material is iron powder, citric acid, wood powder, activated carbon and water, and mass ratio is：16:3:4.5:1:2.It is interior
Bag is made of non-woven fabrics, and outer packing is using the polybag for completely cutting off air.
The preparation method of the hydrophilic polymer gel layer 2 includes the following steps：
(1) radix paeoniae rubrathe tablet is taken to put stir-fry in pot has focus for degree to micro-, and taking-up cools completely, and pharmacological property relatively mitigation, living after the radix paeoniae rubrathe is fried
Blood and relieving pain is without in wound, available for the stagnant pain of the stasis of blood.The solarization of Rhizoma Chuanxiong shave is placed in baking oven for 2 days, and oven temperature is controlled 45
DEG C, it is stirred up and down during solarization and baking, to dry as early as possible.Then by the radix paeoniae rubrathe after stir-fry, the Rhizoma Chuanxiong after drying, safflower, hair
It is impregnated two months in the white wine that Chinese ilex and peppermint are 60% in volume fraction of ethanol, wherein, radix paeoniae rubrathe 50g, safflower 100g, Rhizoma Chuanxiong
80g, ilex pubescens 50g, peppermint 10g, white wine 1500ml；
(2) clear liquid is filtered to take；
(3) aquagel is placed in clear liquid and impregnates 5h, taken out up to hydrophilic polymer gel layer.
The fixed bed 1 sticks band for medical Elastic Cloth, and the nonadherent protective layer 3 is medical embossing plastic film.During use
Nonadherent protective layer 3 is thrown off, is covered in internal fistula swelling position with hydrophilic polymer gel layer 2, medical Elastic Cloth sticks band and sticks in
Skin other than swelling position plays the role of fixed, and the heating bag 4 is pasted onto the upper surface of fixed bed 1.Heating bag helps
In the absorption of active ingredient, increase blood circulation, the formation of effective pre- preventing thrombosis.The swelling of patient's internal fistula uses this hair after 24 hours
The patch of bright embodiment 2, effect are as shown in table 4.
Reference examples 5
Hydrophilic polymer gel using polymethylacrylic acid (PMA) be grafted polyethylene glycol (PEG) gel, remaining with this
Inventive embodiments 3 are identical.Same patient uses the patch effect comparison table of embodiment 3 and reference examples 5, as shown in table 4.
Table 4
Table 4 can show that hydrophilic polymer gel is better than reference examples 5 using the effect of aquagel, and reason may
It is that the slow releasing function of aquagel is better than the hydrogel of reference examples 5, drug effect can be kept long-acting, promote the hair of pharmic function
It waves.
Reference examples 6
The dredging collateral face of sticking is not covered with heating bag, remaining is identical with the embodiment of the present invention 3.Same patient uses implementation
The patch effect comparison table of example 3 and reference examples 6, as shown in table 5
Table 5
Upper table can show that dredging collateral sticks dredging collateral patch of the effect better than no heating bag of face covering heating bag, and reason may be
The traditional Chinese medicine ingredients such as Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens is made preferably to evaporate after heating, enhance the work(of blood-activating and qi-promoting wind-expelling pain-stopping
Effect, they interact, and promote the performance of pharmic function.
Claims (7)
1. a kind of hydrophilic polymer gel layer, which is characterized in that it is by Chinese medicine safflower, Rhizoma Chuanxiong, the radix paeoniae rubrathe, ilex pubescens and peppermint
The hydrophilic polymer gel of active constituent composition,
Wherein, the hydrophilic polymer gel is aquagel, and the hydrophilic polymer gel layer is by including
It is prepared by the method for following steps：
(1) after the radix paeoniae rubrathe is fried, cooling is for use；Rhizoma Chuanxiong shave solarization 2 days or more, then in 40 DEG C~45 DEG C drying, for use；
(2) radix paeoniae rubrathe, Rhizoma Chuanxiong, safflower, ilex pubescens and peppermint are impregnated two weeks or more in white wine, wherein, the radix paeoniae rubrathe, Rhizoma Chuanxiong, safflower,
The mass ratio of ilex pubescens and peppermint is (5~10):(5~10):(5~10):(5~10):(0.5~1), the radix paeoniae rubrathe is in white wine
Mass volume ratio is 1:(15~30) g/ml；
(3) clear liquid is filtered to take；
(4) hydrophilic polymer gel aquagel is placed in 4~6h of immersion in clear liquid, taken out up to hydrophilic macromolecule
Gel layer.
2. hydrophilic polymer gel layer according to claim 1, which is characterized in that the volume of ethyl alcohol point in the white wine
Number is 60%~70%.
3. a kind of red dredging collateral patch in river, including heating bag, fixed bed and nonadherent protective layer, which is characterized in that further include claim 1
Or the hydrophilic polymer gel layer described in 2, the fixed bed are fixed with heating bag on one side, the another side of fixed bed is coated with
Hydrophilic polymer gel layer, covered with nonadherent protective layer on hydrophilic polymer gel layer.
4. the red dredging collateral patch in a kind of river according to claim 3, which is characterized in that the heating bag is fixed using bonding method
Above fixed bed.
5. the red dredging collateral patch in a kind of river according to claim 3, which is characterized in that the fixed bed is medicinal non-woven fabrics, doctor
Band is sticked with absorbent gauze or medical Elastic Cloth.
6. the red dredging collateral patch in a kind of river according to claim 3, which is characterized in that the nonadherent protective layer is medical embossing plastic
Expect film.
7. the red dredging collateral patch in a kind of river according to claim 3, which is characterized in that the heating bag includes outer packing, inner bag
With the exothermic material in inner bag, the exothermic material is iron powder, citric acid, wood powder, activated carbon and water, and mass ratio is：16:3:
4.5:1:2。
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| CN105496634A (en) * | 2015-12-16 | 2016-04-20 | 安徽苗德堂药业有限公司 | Mammary gland cryotherapy patch and preparation method thereof |
| CN107189081A (en) * | 2017-06-07 | 2017-09-22 | 兰州理工大学 | A kind of Preparation method and use of multi-functional polysaccharide hydrogel |
| CN107441168A (en) * | 2017-09-27 | 2017-12-08 | 山东维赫生物科技有限公司 | Compound peppermint is unsting hydrogel plaster |
| CN111388870A (en) * | 2020-03-21 | 2020-07-10 | 武汉天天健康生物工程有限公司 | Far infrared magnetic therapy patch and preparation method thereof |
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