CN104630055A - Main control board of in-situ hybridization system - Google Patents
Main control board of in-situ hybridization system Download PDFInfo
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- CN104630055A CN104630055A CN201310549115.1A CN201310549115A CN104630055A CN 104630055 A CN104630055 A CN 104630055A CN 201310549115 A CN201310549115 A CN 201310549115A CN 104630055 A CN104630055 A CN 104630055A
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- situ hybridization
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Abstract
The invention provides a main control board of an in-situ hybridization system. The main control board comprises a valve control module, which is used to control the opening/closing of a valve in a pipe connected to a cleaning liquid groove and a valve in another pipe connected to a waste liquid tank in an in-situ hybridization system; a pump control module, which is used to control the operation of a peristaltic pump in the in-situ hybridization system; a motor control module, which is used to control the operation of a motor arranged in a swing-bed device in the in-situ hybridization system; a temperature control module, which is used to control the operation of a temperature control device in the in-situ hybridization system; and a CPU processor module, which is used to communicate with the valve control module, the pump control module, the motor control module, and the temperature control module and control the operation of the valve control module, the pump control module, the motor control module, and the temperature control module according to an in-situ hybridization experiment program. The main control board can achieve embryo hybridization automatically, and the experiment standardization, repeatability, and high-throughput can also be achieved by the main control board.
Description
Technical field
The present invention relates to a kind of switchboard, especially a kind of master control board in situ hybridization system.
Background technology
Hybridization in situ technique detects expression level and the expressive site of gene from rna level, the basic experiment criterions such as immunohistochemical methods and Western blot hybridization detect protein level change, and these are all detect gene and the specific basic fundamental of product spatial and temporal expression thereof and powerful measure in Life Science Experiment.These basic experiment technology have been widely used in the research of developmental biology, anatomy, cytobiology, genetics, evolutionary biology, molecular biology, biotechnology exploitation, immunology and cancer and stem cell etc., and provide huge help for the development and progression in these fields.
Although hybridization in situ technique is a kind of conventional basic experiment technology, this technological step is tediously long and complicated, takes time and effort, and tests the time often needing several days each time, comprising a lot of simple but cleaning repeated with hatch process.And traditional manual operation pattern exist again uninteresting loaded down with trivial details, the shortcoming such as to take time and effort.Therefore, above-mentioned traditional pattern hand-manipulated is difficult to the consistence ensureing total Test process, often affects accuracy and the confidence level of experimental result.In addition, more existing in-situ hybridization methods, test mainly for section or film hybridization, cannot be applied on overall embryo.
In sum, existing hybridization in situ technique has following shortcoming: the step of (1) nucleic acid hybridization in situ is many, the time is grown, easily make mistakes, experimental result unstable; (2) in the experimentation of overall embryo, the duplication of labour is many, and embryo is easily broken; (3) hybridization needs to be equipped with special hybrid heater, and take up room large, control condition is complicated; (4) be difficult to realize high-throughput; And (5) existing self-reacting device cannot realize from moving liquid.
Summary of the invention
The present invention is intended to solve above-described problem.An object of the present invention is to provide any one master control board in situ hybridization system in a kind of overcoming the above problems, automatically to realize overall embryo's crossover process, and realize the stdn of hybridization in situ experiment, repeatability and high-throughput.
To achieve these goals, the invention provides a kind of master control board of in situ hybridization system, described master control board comprises: valve control module, and it is for controlling the opening and closing of valve on the conduit be connected with cleaning liquid groove in described in situ hybridization system and the opening and closing with valve on the tank connected conduit of waste liquid in described in situ hybridization system; Pump control module, it is for controlling the work of peristaltic pump in described in situ hybridization system; Motor control module, it is for controlling the work of motor on shaking table device in described in situ hybridization system; Temperature control modules, it is for controlling the work of temperature control unit in described in situ hybridization system; And CPU processor module, its for respectively with described valve control module, described pump control module, described motor control module, and described temperature control modules communicates, with valve control module according to hybridization in situ experiment time variable control, described pump control module, described motor control module, and the operation of described temperature control modules.
In addition, described master control board also comprises communication interface modules, and described CPU processor module communicates with described communication interface modules.
In addition, described communication interface modules comprises 232 interfaces and USB interface, and wherein, described 232 are used for downloading hybridization in situ experiment program from PC for downloading from PC and upgrading application program and described USB interface.
In addition, described master control board also comprises LCD display module, and described CPU processor module communicates with described LCD display module, and described LCD display module is for showing the working order of described in situ hybridization system.
In addition, described master control board also comprises keyboard interface module, and described CPU processor module communicates with described keyboard interface module, and described keyboard interface module communicates with keyboard.
In addition, described keyboard interface module is also undertaken alternately for operator by described keyboard and described master control board, to be adjusted described hybridization in situ experiment program by operator.
In addition, described master control board also comprises temperature test module, and described temperature test module is for responding to the temperature in hybridizing box.
In addition, described pump control module for controlling the direction of peristaltic pump pumping, number of times that pump is got and speed.
In addition, described CPU processor module adopts the ARM chip of embedded LINUX embedded OS.
In addition, described motor control module also for communicating with the motor on two shaking table devices in described in situ hybridization system respectively simultaneously, to control the work of two motors simultaneously.
The master control board in situ hybridization system of the present invention is adopted to control hybridization in situ experiment process, by the automatic distribution of liquid and recovery, example reaction temperature and the automatic control of environment and the automatic control of reagent dosage, whole overall embryonic in situ hybrid experiment is made to realize automatization.In addition, master control board in situ hybridization system can the experimental procedure of Criterion, the experiment reagent of selection standard, thus allow numerous and diverse experiment become simple, as long as set experiment condition, just can repeat experiment very simply, and not worry, due to the change of condition and uncontrollable, occurring different experimental results.Again, the master control board in situ hybridization system controls automatically to a large amount of sample experiments process of operation, is convenient to the high-throughput realizing experiment.
Adopt technical scheme of the present invention, automatically can realize overall embryo's crossover process, and realize the stdn of hybridization in situ experiment, repeatability and high-throughput.
Accompanying drawing explanation
To be incorporated in specification sheets and the accompanying drawing forming a part for specification sheets shows embodiments of the invention, and together with the description for explaining principle of the present invention.In the drawings, similar Reference numeral is used for key element like representation class.Accompanying drawing in the following describes is some embodiments of the present invention, instead of whole embodiment.For those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can be obtained according to these accompanying drawings.
Fig. 1 is the structural representation according to the master control board in situ hybridization system of the present invention; And
Fig. 2 is another structural representation according to the master control board in situ hybridization system of the present invention.
Embodiment
For making the object, technical solutions and advantages of the present invention clearly understand, hereinafter will be described in detail to embodiments of the invention by reference to the accompanying drawings.It should be noted that, when not conflicting, the embodiment in the application and the feature in embodiment can arbitrary combination mutually.
Master control board in situ hybridization system according to the present invention comprises CPU processor module, valve control module, pump control module, motor control module, and temperature control modules.Wherein, CPU processor module respectively with valve control module, pump control module, motor control module, and temperature control modules communicates.
Below with reference to the accompanying drawings, modules and the annexation thereof of the master control board being used in situ hybridization system is described in detail.
With reference to shown in Fig. 1, the master control board in situ hybridization system according to the present invention comprises: CPU processor module, valve control module, pump control module, motor control module, and temperature control modules.As can be seen from Figure 1, CPU processor module respectively with valve control module, pump control module, motor control module, and temperature control modules communicates, to control the work of these modules.
First the modules included by the master control board in situ hybridization system of the present invention is described below in detail:
CPU processor module adopts embedded ARM chip of simplifying LINUX embedded OS.This embedded operating system makes ARM chip can well realize man-machine interaction, communication and various controlling functions, and possesses on-line maintenance and remote upgrade ability.CPU processor module respectively with communication interface modules, valve control module, pump control module, motor control module, and temperature control modules communicates, to control the operation of these modules according to the hybridization in situ experiment program stored in CPU processor module.
Particularly, CPU processor module is according to the hybridization in situ experiment scheme wherein stored and program, the opening and closing of the multiple valves be connected with the conduit in cleaning liquid groove in situ hybridization system is controlled by valve control module, and the opening and closing of the valve to be connected with the conduit in waste liquid tank in situ hybridization system, to realize the discharge of selection to different cleaning liquid and waste liquid.CPU processor module controls the operating mode of peristaltic pump in situ hybridization system by pump control module, to realize injecting the accurate quantification of cleaning liquid and the discharge of waste liquid.CPU processor module also controls the shake pattern of shaking table device in situ hybridization system by motor control module, to realize cleaning and the hybridization of embryo in hybridization in situ experiment process.In addition, CPU processor module also controls the temperature control unit in situ hybridization system by temperature control modules, thus controls the temperature of the hybridizing box in situ hybridization system, and hybrid experiment is carried out according to the temperature of program setting.
Valve control module is for controlling the opening and closing of valve on the conduit be connected with cleaning liquid groove in situ hybridization system and the opening and closing with valve on the tank connected conduit of waste liquid.CPU processor module communicates with this valve control module, and valve control module communicates with the supravasal valve of every root.When according to the program of hybrid experiment, CPU processor module judges that a kind of cleaning liquid cleaning embryo chosen by needs, CPU processor module, with regard to the supravasal valve opening of cleaning liquid needed for indicator valve door control module control linkage, connects the supravasal valve of other cleaning liquids and connects the supravasal valve closes of waste liquid tank.Cleaning liquid selected so just can enter changing in liquid bath of the hybridizing box of in situ hybridization system by the valve opened under the effect of peristaltic pump.Certainly, according to the needs of cross experiment program, CPU processor module also can be opened supravasal multiple valve of indicator valve door control module control linkage multiple kinds of cleaning agent body simultaneously, changes liquid bath with what this multiple kinds of cleaning agent body is injected the hybridizing box of in situ hybridization system simultaneously.When CPU processor module according to the program of hybrid experiment judge to need from the hybridizing box of in situ hybridization system change effluent discharge liquid bath time, with regard to the supravasal valve opening of indicator valve door control module control linkage waste liquid tank, the supravasal valve connecting all cleaning liquids is all closed.The waste liquid changed like this in liquid bath just enters waste liquid tank by the valve of that unlatching under the effect of peristaltic pump.In order to integrated accessibility, valve control module adopts the large rate electronic switch chip of integrated digital hyperchannel to reduce its volume.
Pump control module, for controlling the operating mode of peristaltic pump in situ hybridization system, comprises the direction of peristaltic pump pumping, number of times that pump is got and speed.CPU processor module communicates with pump control module, and pump control module communicates with the peristaltic pump in situ hybridization system.CPU processor module requires to obtain the number of times of peristaltic pump when often kind of liquid got by pump and speed according to the consumption of cleaning liquid various in hybridization in situ experiment program, and the pump obtained is got number of times and speed is transferred to pump control module, then pump control module gets according to the pump received from CPU processor module the work that number of times and speed control peristaltic pump.In addition, CPU processor module is also according to being the direction of getting cleaning liquid from cleaning liquid groove pump or the waste liquid hybridizing box being ejected control pumping.
Motor control module is for controlling the work of motor on shaking table device in situ hybridization system.CPU processor module communicates with motor control module, and motor control module communicates with the motor on shaking table device in situ hybridization system.Motor on shaking table device can be stepper-motor, and therefore motor control module can be step motor control module.When CPU processor module judges to need clean the embryo in the hybridizing box in situ hybridization system or hybridize according to hybridization in situ experiment, just experimentally program obtains the pattern of shaking table device shake, comprise amplitude and the frequency of shake, and by the amplitude of this shake and frequency transmission to motor control module.Then, motor control module just according to the work of motor on the shake amplitude received and frequency control shaking table device, to make shaking table device shake according to the needs of experimental arrangement, thus realizes dynamic cleaning and the hybridization of embryo.In addition, this motor control module can communicate with the motor on two shaking table devices respectively, to control the work of these two motors simultaneously, thus makes it possible to carry out two hybridization in situ experiment simultaneously.Now, these two hybridization in situ experiment simultaneously performed adopt identical experimental arrangement.
Temperature control modules for controlling the work of temperature control unit in situ hybridization system, thus controls the temperature of hybridization in situ experiment.CPU processor module communicates with temperature control modules, and temperature control modules communicates with the temperature control unit in situ hybridization system.CPU processor module obtains the current required temperature of hybridization in situ experiment according to hybridization in situ experiment program, and this temperature is transferred to temperature control modules.The temperature sensor of temperature control modules also from situ hybridization system on temperature control unit obtains the current actual temperature of hybridization in situ experiment.Then, the current required temperature of the hybridization in situ experiment that temperature control modules is obtained is compared with the current actual temperature of hybridization in situ experiment, judge it is the current actual temperature needing to increase or reduce hybridization in situ experiment, and control the work of temperature control unit in situ hybridization system according to this, comprise and reduce the current actual temperature of hybridization in situ experiment by the scatterer of temperature control unit in situ hybridization system and increase the current actual temperature of hybridization in situ experiment by the well heater of temperature control unit in situ hybridization system.Temperature control modules can be semiconductor temperature-control driver module, and this semiconductor temperature-control driver module adopts metal-oxide-semiconductor half-bridge circuit, and heating and refrigeration are switched freely.
In addition, communication interface modules can also be comprised according to the master control board in situ hybridization system of the present invention.Communication interface modules comprises 232 interfaces and USB interface, and CPU processor module communicates with this 232 interface and USB interface, to control its download carrying out program and renewal.Wherein, 232 interfaces are connected with the serial communication port of computer and are used for downloading and upgrading system application, and this system application is for controlling the operational process of whole system, and 232 interfaces can realize local download and remote download.USB interface is used for communicating with PC, and CPU processor module receives from PC the hybridization in situ experiment scheme and program that upper computer management software issues by the USB interface in communication interface modules.Only have after master control board and PC establish a communications link, the experimental arrangement worked out on PC in advance is just downloaded on the master control board of in situ hybridization system by by USB interface.Then master control board is according to the enforcement of the experimental arrangement downloaded by CPU processor module Control release.
In addition, LCD display module can also be comprised according to the master control board in situ hybridization system of the present invention.CPU processor module communicates with LCD display module, the various state transfer of hybridization in situ experiment to be shown by it to LCD display module.Various states shown by LCD display module comprise the current temperature of reagent of hybridization in situ experiment, current valve opening and closure state, current peristaltic pump working order, current shaking table device working order, and current experimental temperature.Wherein, this temperature of reagent can experience temperature of reagent by the digital thermometric chip on the heating aluminium alloy post below the temperature test module induction hybridizing box on master control board.And, when motor control module controls the machine operation of two shaking table devices simultaneously, LCD display module can show the experimental state changing liquid bath in two hybridizing boxes simultaneously, and the experimental state that liquid bath is changed in perception is carried out in this position can detecting optoelectronic switch by master control board.This LCD display module can adopt 5.6 cun of true color screens, and comprises LCD driving chip and serial line interface, so that carry out man-machine interaction.
In addition, keyboard interface module can also be comprised according to the master control board in situ hybridization system of the present invention.Keyboard interface module is used for communicating with keyboard, so that operator is undertaken by keyboard and in situ hybridization system alternately.CPU processor module communicates with keyboard interface module, thus when operator by keyboard input information time, keyboard by keyboard interface module by this information transmission to CPU processor module.Like this, CPU processor module just can control according to the information of operator's input accordingly.Such as, operator can be selected by the program of keyboard to hybridization in situ experiment and start corresponding experimental arrangement.Operator can also according to practical situation need hybridization in situ experiment program ongoing in master control board is adjusted, such as adjust pump and get the order of reagent or dosage, regulation experiment temperature, the shake of adjustment shaking table device amplitude and frequency etc., reach rapidly default requirement to make the cleaning of embryo or hybridization environment.
In addition, temperature test module can also be comprised according to the master control board in situ hybridization system of the present invention.Temperature test module is for being transferred to CPU by the temperature of the digital thermometric chip testing on the heating aluminium alloy post below hybridizing box.
According to the master control board in situ hybridization system of the present invention according to actual needs, above-mentioned communication interface modules, LCD display module, keyboard interface module can be comprised, and one or more in temperature test module.The master control board of the in situ hybridization system shown in Fig. 2 comprises above-mentioned all modules.
The above-mentioned master control board in situ hybridization system according to the present invention describes for the application scenarios of the cleaning of embryo and hybridization, it will be appreciated by those skilled in the art that, application according to the master control board in situ hybridization system of the present invention is not limited to this, and it also may be used for other purposes.In addition, the master control board in situ hybridization system according to the present invention can be used for various hybridization in situ experiment, comprises nucleic acid hybridization in situ experiment.
The master control board in situ hybridization system of the present invention is adopted to control hybridization in situ experiment process, by the automatic distribution of liquid and recovery, example reaction temperature and the automatic control of environment and the automatic control of reagent dosage, whole overall embryonic in situ hybrid experiment is made to realize automatization.In addition, master control board in situ hybridization system can the experimental procedure of Criterion, the experiment reagent of selection standard, thus allow numerous and diverse experiment become simple, as long as set experiment condition, just can repeat experiment very simply, and not worry, due to the change of condition and uncontrollable, occurring different experimental results.Again, the master control board in situ hybridization system controls automatically to a large amount of sample experiments process of operation, is convenient to the high-throughput realizing experiment.
Above embodiment only in order to technical scheme of the present invention and unrestricted to be described, only with reference to preferred embodiment to invention has been detailed description.Those of ordinary skill in the art should be appreciated that and can modify to technical scheme of the present invention or equivalent replacement, and does not depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (10)
1. for a master control board in situ hybridization system, it is characterized in that, described master control board comprises:
Valve control module, it is for controlling the opening and closing of valve on the conduit be connected with cleaning liquid groove in described in situ hybridization system and the opening and closing with valve on the tank connected conduit of waste liquid in described in situ hybridization system;
Pump control module, it is for controlling the work of peristaltic pump in described in situ hybridization system;
Motor control module, it is for controlling the work of motor on shaking table device in described in situ hybridization system;
Temperature control modules, it is for controlling the work of temperature control unit in described in situ hybridization system; And
CPU processor module, its for respectively with described valve control module, described pump control module, described motor control module, and described temperature control modules communicates, with valve control module according to hybridization in situ experiment time variable control, described pump control module, described motor control module, and the operation of described temperature control modules.
2. master control board as claimed in claim 1, it is characterized in that, described master control board also comprises communication interface modules, and described CPU processor module communicates with described communication interface modules.
3. master control board as claimed in claim 2, it is characterized in that, described communication interface modules comprises 232 interfaces and USB interface, and wherein, described 232 are used for downloading hybridization in situ experiment program from PC for downloading from PC and upgrading application program and described USB interface.
4. master control board as claimed in claim 1, it is characterized in that, described master control board also comprises LCD display module, and described CPU processor module communicates with described LCD display module, and described LCD display module is for showing the working order of described in situ hybridization system.
5. master control board as claimed in claim 1, it is characterized in that, described master control board also comprises keyboard interface module, and described CPU processor module communicates with described keyboard interface module, and described keyboard interface module communicates with keyboard.
6. master control board as claimed in claim 5, it is characterized in that, described keyboard interface module is also undertaken alternately for operator by described keyboard and described master control board, to be adjusted described hybridization in situ experiment program by operator.
7. master control board as claimed in claim 1, it is characterized in that, described master control board also comprises temperature test module, and described temperature test module is for responding to the temperature in hybridizing box.
8. master control board as claimed in claim 1, is characterized in that, described pump control module for controlling the direction of peristaltic pump pumping, number of times that pump is got and speed.
9. master control board as claimed in claim 1, it is characterized in that, described CPU processor module adopts the ARM chip of embedded LINUX embedded OS.
10. master control board as claimed in claim 1, is characterized in that, described motor control module also for communicating with the motor on two shaking table devices in described in situ hybridization system respectively simultaneously, to control the work of two motors simultaneously.
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| CN201310549115.1A CN104630055A (en) | 2013-11-08 | 2013-11-08 | Main control board of in-situ hybridization system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110272821A (en) * | 2018-03-13 | 2019-09-24 | 赵炜 | Full-automatic in situ hybridization device and method |
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| CN1726275A (en) * | 2002-12-20 | 2006-01-25 | 达可斯通(丹麦)公司 | Method and apparatus for auto-dyeing of tissue slides |
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Application publication date: 20150520 |