CN104623220A - Traditional Chinese medicine composition for treating acute mastitis and application of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating acute mastitis and application of traditional Chinese medicine composition Download PDF

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CN104623220A
CN104623220A CN201510101864.7A CN201510101864A CN104623220A CN 104623220 A CN104623220 A CN 104623220A CN 201510101864 A CN201510101864 A CN 201510101864A CN 104623220 A CN104623220 A CN 104623220A
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chinese medicine
medicine composition
traditional chinese
acute mastitis
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王宁
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Abstract

The invention discloses a traditional Chinese medicine composition for treating acute mastitis, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials: fiveleaf akebia fruit, chachi citrus leaf, achyranthes bidentata, Japanese conehead herb, smilax riparia, salvia chinensis, holboellia latifolia, bower actinidia root and leaf, pangolin, adiantum capillus-veneris and gynura bicolor. The traditional Chinese medicine composition is reasonable in compatibility, brings out the best in each other, works together to reach the efficacies of strengthening the body resistance and cultivating constitution, and has the efficacies of soothing the liver, harmonizing the stomach, promoting the qi circulation, relieving chest stuffiness, activating blood circulation, dredging main and collateral channels, clearing heat, eliminating stagnant blood, expelling pus and relieving pain, so that the target of treating acute mastitis is reached, and the traditional Chinese medicine composition is good in effect, fast in acting, safe and free of a toxic and side effect.

Description

A kind of Chinese medicine composition and application thereof for the treatment of acute mastitis
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of Chinese medicine composition for the treatment of acute mastitis.
Background technology
Acute mastitis refers to i.e. acute mastitis, name of disease.Sending out in breast person of carbuncle.Go out " rescuing soldier side after elbow " volume five.Have another name called (Epileptic torr) breast, Jealousy be newborn, breast is malicious, blow you, blow breast, in blow, postpartum mastitis, infrapapillary carbuncle, newborn crazy etc.Many because of irritability stasis, gastric heat is jammed, galactostasis, and the pathogens agglomerating of sense wind and cold of holding concurrently is poly-and send out." General Treatise on the Cause and Symptoms of Diseases the miscellaneous internal diseases in woman ": " also have because milk stores knot, fight mutually with blood, accumulate long-pending heat-dissipating, knot is poly-forms acute mastitis person ".From the beginning of person, card is shown in that the scleroma of differing in size appears in breast portion, begins to feel that distending pain, milk suck freely stasis, feels whole body aversion to cold fever gradually, or headache, and podomere is uncomfortable.Continue, lump increases , inflammation erythralgia and adds, and cold and heat do not move back, and very then the pain increased, generalized muscle ache and weakness, and local lump is by hard and soft change, and having fluctuation, is formed pus.This disease is early stage, controls suitable liver-smoothing, qi-regulating, heat clearing away of invigorating blood circulation, lactogenesis eliminating stagnation.Be more common in women's puerperal, its cause of disease has because of depression of liver-QI, accumulation of stomach-heat; Or because of galactostasis; Or nursing infant's damage nipple when inhaling breast, infect pyretic toxicity; Or puerperal blood deficiency, being invaded by exogenous pathogen, so that damp-heat accumulation, coagulation of QI-blood forms.Have the medicine of multiple treatment acute mastitis in prior art, but it is large to there is toxic and side effects, the problems such as the course for the treatment of is long, and therapeutic effect is undesirable.
Summary of the invention
The present invention, for solving above-mentioned Problems existing, provides a kind of safe without toxic side effect, determined curative effect, can the Chinese medicine composition for the treatment of acute mastitis for the treatment of both the principal and secondary aspects of a disease.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine composition for acute mastitis, be made up of following weight parts Chinese crude drug: Fructus Akebiae 40-42 part, Citrus chachiensis Hort. (C. Suavissima Tanaka) 38-40 part, Radix Achyranthis Bidentatae 36-38 part, Herba Strobilanthis Japonici 41-43 part, Radix et Rhizoma Smilacis Ripariae 36-38 part, Herba Salviae Chinensis 32-34 part, Fructus Akebiae 28-30 part, Radix actinidiae argutae 31-33 part, Squama Manis 21-23 part, black nylon yarn 17-19 part, Herba Gynurae bicoloris 10-12 part.
Preferably, the Chinese medicine composition of above-mentioned treatment acute mastitis, is made up of following weight parts Chinese crude drug: Fructus Akebiae 41 parts, Citrus chachiensis Hort. (C. Suavissima Tanaka) 39 parts, Radix Achyranthis Bidentatae 37 parts, Herba Strobilanthis Japonici 42 parts, Radix et Rhizoma Smilacis Ripariae 37 parts, Herba Salviae Chinensis 33 parts, Fructus Akebiae 29 parts, Radix actinidiae argutae 32 parts, Squama Manis 22 parts, black nylon yarn 18 parts, Herba Gynurae bicoloris 11 parts.
According to Chinese medicine Historical Data Data About, above-mentioned each Chinese crude drug possesses following pharmacologically active:
Herba Strobilanthis Japonici, [nature and flavor] are pungent, temperature.[function cures mainly] promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.For dysmenorrhea, pelvic inflammatory disease, puerperal abdonimal pain, traumatic injury, rheumatic ostalgia." Chinese herbal medicine is commonly used in Sichuan ": " the capable water of repercussive, soothing liver-QI falls apart strongly fragrant.Control menoxenia, puerperal dripping stomachache, bruise, lump in the abdomen carbuncle, traumatic injury and body and face edema.”
Radix Achyranthis Bidentatae, [nature and flavor] are bitter, sour, flat.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Herba Salviae Chinensis, [nature and flavor] micro-hardship, flat.[function cures mainly] blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating.Main menoxenia; Dysmenorrhea; Amenorrhea; Metrorrhagia, has blood in stool; Jaundice due to damp-heat; Hot toxic-heat and blood stasis; Drench pain; Leukorrhagia; Rheumatic ostalgia; Scrofula; Skin ulcer swells; Acute mastitis; Herpes zoster; Leprosy; Traumatic injury wound is swollen.
Radix et Rhizoma Smilacis Ripariae, [function cures mainly] inrigorating qi and promoting blood circulation, channels sootheing and network vessel quickening.Control deficiency of vital energy edema, bones and muscles pain, hemiplegia, dizziness headache, cough is spitted blood, bone tuberculosis, leucorrhea.
Herba Gynurae bicoloris, [nature and flavor] acrid in the mouth; Sweet; Cool in nature.[function cures mainly] clearing away heat and cooling blood; Removing toxic substances disappears.Main hemoptysis; Metrorrhagia; Traumatic hemorrhage; Dysmenorrhea; Dysentery; Sore swollen toxin; Traumatic injury; Ulcer does not restrain for a long time.
Radix actinidiae argutae, [function cures mainly] stomach invigorating, heat clearing away, dampness removing.Control dyspepsia, vomiting, diarrhoea, jaundice, rheumatic arthritis.
Fructus Akebiae, [nature and flavor] are bitter; Cool.[return through] bladder; The heart; Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Blood circulation and channel invigorating; Promoting the circulation of QI to relieve pain.Main oliguria with reddish urine; Stranguria with turbid discharge; Edema; Rheumatic arthralgia; Traumatic injury; Galactostasis; Colicky; Uterine prolapse; Orchitis.
Black nylon yarn, [nature and flavor] are light; Flat.[return through] lung; Urinary bladder channel.[function cures mainly] clearing away lung-heat to relieve cough; Relieving stranguria by diuresis; Eliminating carbuncle stimulating milk secretion.Main cough due to lung-heat; Urine leaching pain; Acute mastitis swells and ache; Agalactia.
Squama Manis, [nature and flavor] are salty, are slightly cold.[return through] returns liver, stomach warp.[function cures mainly] stimulates the menstrual flow stimulating milk secretion, detumescence and apocenosis, expel wind to dredge collateral.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Fructus Akebiae, [nature and flavor] hide micro-hardship, and property is put down.Return liver, stomach, urinary bladder channel.[return through] liver; Stomach warp.[function cures mainly] dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
Citrus chachiensis Hort. (C. Suavissima Tanaka), [nature and flavor] are pungent; Bitter; Flat.[return through] spleen; Stomach; Liver Channel.[function cures mainly] circulation of qi promoting the chest stuffiness relieving; Dispersing the stagnated liver-QI for regulating the stomach; Removing toxicity for eliminating carbuncles.Main septum pectorale is full vexed; Distending pain over the hypochondrium; Blockage of menstruation; Diaphragm carbuncle; Acute mastitis; Breast carcinoma.
Found by a large amount of clinical practice, Chinese medicine composition of the present invention has the advantage such as determined curative effect, Be very effective for treatment acute mastitis.Therefore, present invention also offers a kind of new pharmaceutical use, that is: the application of above-mentioned Chinese medicine composition in the medicine of preparation treatment acute mastitis.
The preparation method that the present invention treats the Chinese medicine preparation of acute mastitis comprises the steps: to take each Chinese crude drug of weight portion, then adds the soak by water 1-1.5h of medical material weight 10-15 times amount, filters, and collects filtrate; In medicinal residues, add the soak by water 0.5-1h of medical material weight 10 times amount again, filter, collect filtrate, twice filtrate is merged, is concentrated into liquor capacity: the drug extract of medical material weight=0.5-1: 1, by extractum and adjuvant conveniently technique be prepared as oral liquid.
The present invention is according to folk tradition formula, according to the theory of traditional Chinese medical science the body resistance strengthening and constitution consolidating, dispersing the stagnated live-QI to relieve the stagnation of QI, meticulously develops.All medicine compatibilities, bring out the best in each other, play the body resistance strengthening and constitution consolidating altogether, have effect of dispersing the stagnated liver-QI for regulating the stomach, circulation of qi promoting the chest stuffiness relieving, promoting blood circulation to restore menstrual flow network, heat clearing away dissipating blood stasis, evacuation of pus pain relieving, thus realize the object for the treatment of acute mastitis.It is effective, instant effect, safe without toxic side effect.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
(1) medicine preparation
The preparation of embodiment 1 Chinese medicine oral liquid of the present invention
Prescription: Fructus Akebiae 40 parts, Citrus chachiensis Hort. (C. Suavissima Tanaka) 38 parts, Radix Achyranthis Bidentatae 36 parts, Herba Strobilanthis Japonici 41 parts, Radix et Rhizoma Smilacis Ripariae 36 parts, Herba Salviae Chinensis 32 parts, Fructus Akebiae 28 parts, Radix actinidiae argutae 31 parts, Squama Manis 21 parts, black nylon yarn 17 parts, Herba Gynurae bicoloris 10 parts.
Preparation method: take each Chinese crude drug of weight portion, then adds the soak by water 1-1.5h of medical material weight 10 times amount, filters, and collects filtrate; In medicinal residues, add the soak by water 0.5-1h of medical material weight 10 times amount again, filter, collect filtrate, twice filtrate is merged, is concentrated into liquor capacity: the drug extract of medical material weight=0.5-1: 1, by extractum and adjuvant conveniently technique be prepared as oral liquid.
The preparation of embodiment 2 Chinese medicine oral liquid of the present invention
Prescription: Fructus Akebiae 42 parts, Citrus chachiensis Hort. (C. Suavissima Tanaka) 40 parts, Radix Achyranthis Bidentatae 38 parts, Herba Strobilanthis Japonici 43 parts, Radix et Rhizoma Smilacis Ripariae 38 parts, Herba Salviae Chinensis 34 parts, Fructus Akebiae 30 parts, Radix actinidiae argutae 33 parts, Squama Manis 23 parts, black nylon yarn 19 parts, Herba Gynurae bicoloris 12 parts.
Preparation method is with embodiment 1.
The preparation of embodiment 3 Chinese medicine oral liquid of the present invention
Prescription: Fructus Akebiae 41 parts, Citrus chachiensis Hort. (C. Suavissima Tanaka) 39 parts, Radix Achyranthis Bidentatae 37 parts, Herba Strobilanthis Japonici 42 parts, Radix et Rhizoma Smilacis Ripariae 37 parts, Herba Salviae Chinensis 33 parts, Fructus Akebiae 29 parts, Radix actinidiae argutae 32 parts, Squama Manis 22 parts, black nylon yarn 18 parts, Herba Gynurae bicoloris 11 parts.
Preparation method is with embodiment 1.
(2) acute toxicity and chronic toxicity experiment
Preliminary experiment shows, and oral liquid in the present invention, toxicity is very little, cannot measure LD 50, therefore, according to maximum amount feeding.
1, animal acute toxicity test
Medicine: embodiment of the present invention 1-3 gained Chinese medicine oral liquid.
Experimental animal: regular grade NIH mice, body weight 21g ± 2g, male and female half and half, female rats is all without pregnant.
Method and result:
1), by experiment mice be divided into 4 groups of male and female half and half at random, wherein 3 groups of difference gavages, 3 kinds of Chinese medicine oral liquid, volume is 2ml/10g body weight, remains the normal saline that a group is matched group, gavage same volume, and close observation 8h also notes down, and continues observation 7 days;
2), in 7 days, mice is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirty, and without fainting from fear addicted to saliva, eye, mouth, nose, ear and crissum secretions without exception, without the rotten toe of docking.From 4 groups, select 20 execution (often organizing 5) respectively, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes, and shows that 3 kinds of these Chinese medicine oral liquid are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: embodiment of the present invention 1-3 gained Chinese medicine oral liquid.
Animal: regular grade SD rat, body weight 215g ± 10g, male and female half and half, female rats is all without pregnant.
Method and result:
1), 3 kinds of Chinese medicine oral liquid: be divided into high, medium and low three dosage groups, per weight dosage is respectively 40,20,10 times of patient's dose;
2), by experimental mouse be divided into 10 groups at random, wherein the oral liquid of 9 groups of difference gavages, 3 kinds of three dosage, remains one group of gavage normal saline (40 times of patient's dose); All 10 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
3), through long-term feeding, all there is not toxic reaction in 10 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, think through proved by pathology, 3 kinds of Chinese medicine oral liquid show without chronic toxicity animal.
By above two toxicity tests, prove that the present invention is safe by the Chinese medicine oral liquid that embodiment 1-3 makes, have no side effect, can be taken by patient.
(3) clinical trial
1, case and grouping
Screening acute mastitis patient 102 example, be women breast-feeding their children, diagnosis basis: from the beginning of there being painful lump in breast, skin is not red or micro-red, and milk ejection is smooth, and nipple can be had to break erosion; During suppuration, breast swell and pain increases the weight of, lump deliquescing, has and should refer to sense, after diabrosis or incision and drainage, swells and ache and alleviates; As pus flows out not smooth, swell and ache and do not disappear, the change of " biography capsule " can be had; Do not close up after bursting, seepage flow milk or pus, can form mammary fistula; There is fever with aversion to cold, headache, the symptoms such as the whole body is uncomfortable more; Ipsilateral oxter Ke You Xing core enlargement pain; Most patients is nursing women, is common especially with the primipara of non-full moon; Blood leukocytes sum and neutrophilic granulocyte increase.
All patients are divided into three groups at random, and often organize 34 examples, three groups of patients are through statistical procedures in age, the course of disease etc., and there was no significant difference, has comparability.
2, medication instruction
Three groups of patients are corresponding in turn to each 20ml of oral liquid taking embodiment of the present invention 1-3 and prepare, every day three times, take 1-2 month continuously.
3, therapeutic evaluation
Cure: General Symptoms disappears, lump dissipates, wound healing.
Take a turn for the better: General Symptoms disappears, and partial gall alleviates, or the open sore part not yet heals.
Do not heal: " biography capsule " or formation mammary fistula repeatedly.
4, after treatment, three groups of efficacy results are in table 1.
The comparitive study of table 1 three groups of patients
Can be found out by the result of the test of table 1, three groups of Chinese medicines have significant effect for treatment acute mastitis, and without recurrence, particularly the therapeutic effect of embodiment 3 groups is best.
5, model case
Case 1, Chen, female, 25 years old, 10 days first puerperal, breast congestion and swelling pain, milk is discharged smooth, has lump in breast, and western medicine one month is invalid, after take Chinese medicine oral liquid of the present invention, after 3 days, swell and ache and obviously alleviate, continue to take two months, full mistake of swelling and ache, cures.
Case 2, Wang, female, 29 years old, in 10 days first puerperal, right breast lump increased gradually, and skin rubefaction is scorching hot, and pain is pulsation, has tenderness, and right side axillary gland enlargement, takes Chinese medicine composition of the present invention, takes after two months, recovery from illness, without swelling and ache sense.
Case 3, Lee, female, 34 years old, have two babies, produce latter two weeks, breast swell and pain, milk is not smooth, has lump, red swelling of the skin in right breast, have obvious pain, after take Chinese medicine composition of the present invention, after taking 10 days, pain obviously alleviates, and lump softness diminishes, and continues to take after two months afterwards, lump in right breast disappears, painless, cures.

Claims (4)

1. treat a Chinese medicine composition for acute mastitis, it is characterized in that being made up of following weight parts Chinese crude drug: Fructus Akebiae 40-42 part, Citrus chachiensis Hort. (C. Suavissima Tanaka) 38-40 part, Radix Achyranthis Bidentatae 36-38 part, Herba Strobilanthis Japonici 41-43 part, Radix et Rhizoma Smilacis Ripariae 36-38 part, Herba Salviae Chinensis 32-34 part, Fructus Akebiae 28-30 part, Radix actinidiae argutae 31-33 part, Squama Manis 21-23 part, black nylon yarn 17-19 part, Herba Gynurae bicoloris 10-12 part.
2. treat the Chinese medicine composition of acute mastitis as claimed in claim 1, it is characterized in that being made up of following weight parts Chinese crude drug: Fructus Akebiae 41 parts, Citrus chachiensis Hort. (C. Suavissima Tanaka) 39 parts, Radix Achyranthis Bidentatae 37 parts, Herba Strobilanthis Japonici 42 parts, Radix et Rhizoma Smilacis Ripariae 37 parts, Herba Salviae Chinensis 33 parts, Fructus Akebiae 29 parts, Radix actinidiae argutae 32 parts, Squama Manis 22 parts, black nylon yarn 18 parts, Herba Gynurae bicoloris 11 parts.
3. the process for preparing medicine of the Chinese medicine composition for the treatment of acute mastitis as claimed in claim 1 or 2, is characterized in that comprising the following steps: take each Chinese crude drug of weight portion, then adds the soak by water 1-1.5h of medical material weight 10-15 times amount, filter, collect filtrate; In medicinal residues, add the soak by water 0.5-1h of medical material weight 10 times amount again, filter, collect filtrate, twice filtrate is merged, is concentrated into liquor capacity: the drug extract of medical material weight=0.5-1: 1, by extractum and adjuvant conveniently technique be prepared as oral liquid.
4. the application of Chinese medicine composition in the medicine of preparation treatment acute mastitis of the treatment acute mastitis described in right 1 or 2.
CN201510101864.7A 2015-03-09 2015-03-09 Traditional Chinese medicine composition for treating acute mastitis and application of traditional Chinese medicine composition Withdrawn CN104623220A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105363011A (en) * 2015-12-18 2016-03-02 青岛市第三人民医院 Medicinal moxa stick for treating qi stagnation and phlegm stasis type breast lumps
CN105362675A (en) * 2015-12-22 2016-03-02 青岛海之源智能技术有限公司 Emulsifiable paste for treating plasmacellular mastitis and preparation method thereof
CN105920292A (en) * 2016-06-25 2016-09-07 丁常燕 Chinese medicinal composition for treating acute mastitis
CN105943733A (en) * 2016-06-22 2016-09-21 岳宁宁 Traditional Chinese medicine composition for treating mammary carbuncles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579912A (en) * 2012-04-01 2012-07-18 李佃场 Chinese medicinal capsules special for treating acute mastitis and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579912A (en) * 2012-04-01 2012-07-18 李佃场 Chinese medicinal capsules special for treating acute mastitis and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105363011A (en) * 2015-12-18 2016-03-02 青岛市第三人民医院 Medicinal moxa stick for treating qi stagnation and phlegm stasis type breast lumps
CN105362675A (en) * 2015-12-22 2016-03-02 青岛海之源智能技术有限公司 Emulsifiable paste for treating plasmacellular mastitis and preparation method thereof
CN105943733A (en) * 2016-06-22 2016-09-21 岳宁宁 Traditional Chinese medicine composition for treating mammary carbuncles
CN105920292A (en) * 2016-06-25 2016-09-07 丁常燕 Chinese medicinal composition for treating acute mastitis

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