CN104606712B - A kind of bionical bioceramic with through hole structure and its preparation method and application - Google Patents
A kind of bionical bioceramic with through hole structure and its preparation method and application Download PDFInfo
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- CN104606712B CN104606712B CN201410853889.8A CN201410853889A CN104606712B CN 104606712 B CN104606712 B CN 104606712B CN 201410853889 A CN201410853889 A CN 201410853889A CN 104606712 B CN104606712 B CN 104606712B
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Abstract
The invention belongs to bionical bioceramic technical field, disclose a kind of bionical bioceramic with through hole structure and its preparation method and application.The preparation method of the described bionical bioceramic with through hole structure is: first prepare the mould with through filament, then organic plastics granule is added in mould and prepare plastics porous support, then ceramics and binding agent are inserted in the hole of plastics porous support, removing through filament and plastics porous support, sintering obtains the bionical bioceramic with through hole structure the most at a certain temperature.Present invention shape, size and distribution by through filament, can realize the good control to bionical bioceramic through hole shape, size and density, and it has significant advantage in the replacement reparation or tissue engineering bracket of spongy bone.
Description
Technical field
The invention belongs to bionical bioceramic technical field, be specifically related to a kind of there is the bionical of through hole structure
Bioceramic and its preparation method and application.
Background technology
One of Cranial defect difficult problems being always field of orthopaedics caused such as fracture, osteopathia and bone cyst.Bone Defect Repari
Material is mainly autologous bone, allograph bone and artificial bone, and multiporous biological active ceramic artificial bone is good with it
Biocompatibility and degradability become preferable osseous tissue and substitute and repair materials.
For porous bio-ceramic, existing multiple preparation method and application:
Patent CN 101690828 A discloses the preparation method of a kind of gradient porous bioceramic scaffold, passes through
Manufacture three-dimensional shells, cast bioceramic slurry, lyophilization and sintering step, prepared outside relative
The porous bioceramic scaffold of the layered porous structure fine and close, inside has oriented alignment.But described in this invention
Bioceramic scaffold Kong Yukong between connectedness indefinite, there is no assurance that dextrin, polyvinyl alcohol
Deng the whole burn off of binding agent.
Patent CN 101524555 A discloses the preparation method of a kind of combined porous biological ceramics bracket, logical
Cross the spherical granule of manufacture bioceramic, manufacture the step such as three-dimensional shells, assembling, be manufactured that there is outside phase
To fine and close, the gradient-porosity porous bioceramic scaffold of loose and porous inner surface.
Patent CN 101011602 A discloses the preparation method of a kind of porous bioceramic scaffold, uses poly-second
Enol aqueous solution makees binding agent, mixs homogeneously with bioceramic powder body, through orifice plate extruding, cuts off and round as a ball,
Manufacture spheroidal particle；Take polyvinyl alcohol water solution again to mix with above-mentioned granule, compression molding in a mold, put
Enter sintering furnace sintering.
Patent CN 101352583 A discloses a kind of stephanoporate calcium polyphosphate biological ceramic, is added by CPP powder
Water and xanthan gum are made into slurry, are subsequently adding chitosan microball and are dried to gypsum mold, and finally sintering obtains many
Hole calcium polyphosphate biological ceramic.
Patent CN 1927769 A discloses preparation method and the device of a kind of nano porous biologic ceramics: it is special
Point is synthesis to have the slurry of nanostructured be performing centrifugal separation on rear gained thick paste and add foaming agent and become porous germule
Body, through 300～800 DEG C of plastic removals；First idiosome is carried out microwave sintering, it is thus achieved that there is the biological pottery of nanostructured
Porcelain products.
Patent CN 102515849 A discloses a kind of surface layer and is made pottery by the multiporous biological of calcium phosphate nano bar construction
Porcelain and constructive method thereof.The method is to use hydro-thermal method to constitute surface layer to have the porous life of calcium phosphate nano rod
Thing pottery, this calcium phosphate nano rod is to have the calcium phosphate porous ceramic base of same or analogous chemical composition
The growth of basal surface extensionality is formed.
Patent CN 1793057 A discloses the preparation method of a kind of layered porous calcium phosphate biological ceramic and answers
With, use supercritical ultrasonics technology to obtain the compound colloidal solution of bovine serum albumin and calcium phosphate, then placement, old
Change, obtain starchiness precipitate；Starchiness precipitate is inserted molding in container, carries out freezing dry after freezing
The dry presoma obtaining there is layer structure；Finally 600～1000 DEG C of roastings 1 hour, remove albumin mould
Plate, and form porous calcium phosphate biological ceramic.
Patent CN 102276291 A discloses a kind of method preparing porous calcium phosphate bioceramic material, will
It is added to before hydroxyapatite in die casting, is compacted and keeps certain time, idiosome is warmed up to
200～500 DEG C are sintered, and insulation 0.5～2.0h, is then heated to may insure that hydroxy-apatite at such a temperature
The temperature undergone phase transition mutually before stone, reaches this and may insure that the temperature undergone phase transition i.e. stops heating, allow idiosome
In agglomerating plant, naturally cool to room temperature, i.e. obtain porous calcium phosphate bioceramic material.
Patent CN 101766843 A discloses the artificial bone of a kind of porous laminated structure and passage, by calcium phosphate
The dense layer of base bioceramic material and porous layer alternative stacked molding, and the side of set angle is being become with lamination
Set up conveying cell, the passage of body fluid.By the powder such as hydroxyapatite, beta-calcium phosphate with deionization
Water is that medium is mixed to prepare slurry.Using three dimensional gel laminated forming system, preparation is by dense layer, porous layer
The ceramic idiosome formed with passage, then through high temperature sintering, prepare artificial bone.Although this application is mentioned with folded
Layer becomes to be provided with on the direction of set angle conveying cell, the passage of body fluid, but its porous part uses to be sent out
Infusion fabrication techniques, porous connectedness is uncontrollable.
Patent CN 102512267 A discloses a kind of bone restoration body with composite porous structure and preparation method thereof, institute
State preparation method direct metal rapid shaping technique to be combined with Freeze Drying Technique, first pass through structure design
With porous metals support at direct metal rapid shaping technique manufacture, then by the polymer of mix homogeneously/biology pottery
Porcelain mixed solution is poured in porous metals support, and carries out freezing processing, thus obtains compound porous structure
Bone repair.
Patent CN 103182099 A discloses a kind of porous active artificial bone, with calcium orthophosphate base bioceramic material
Material is matrix, including aperture, dense portion and directional hole passage, and chelates diphosphonate.Although this application
Mention the concept in orientation duct, but can not accomplish between hole and the connectedness in orientation duct.
Patent CN 1850293 A discloses a kind of medical reinforced porous biological ceramic, preparation method and answers
With.This bioceramic contains porous and tight section, and tight section primarily serves increase mechanical strength effect,
Porous part mainly makes cell and tissue grow among pottery, makes new life's to organize the formation of corresponding function.
Patent CN 103113129 A discloses a kind of multi-stage porous bioactive ceramics and preparation method and application.
The present invention, by binding agent, plasticizer, pore creating material and solvent being mixed, obtains pore creating material viscous solution；Again will
Bioactive powder joins in pore creating material viscous solution mixing, obtains high plasticity walk；It is used for squeezing by walk
Go out molding, after sintering, obtain cellular multi-stage porous bioactive ceramics.
(M.Descamps et.al. is at Synthesis of macroporous β for M.Descamps etc.
-tricalcium phosphate with controlled porous architectural) pass through PMMA granule as cause
Hole agent becomes support by hot melt adhesive together, then is made into by bioceramic granule in serosity injection support,
Sinter porous bio-ceramic into.Although the porous ceramics porous that the method prepares is good, but internal material
The excessively complicated connectivity within lack of materials of structure.Scholar is currently also had to use fascial flap to wrap up this biology pottery
Porcelain, improves its blood supply problem, but stem cell still can only be in periphery enrichment and growth, it is impossible to be distributed in pottery
Internal portion, leverages repairing effect.
The porous ceramics prepared in above patent and document mostly exist internal connect uncontrollable, ditch passband is low or
The problem of connectivity difference, owing to bioactive ceramics is as et al. Ke material, the connection between Kong Yukong
Property and ditch passband is creeped for cell, the degraded of material and angiogenesis significant；In bioceramic
Portion's connectivity is poor, causes bone marrow stem cell to be enriched with in material periphery, it is impossible to be distributed at inner homogeneous, particularly
For nonweight-bearing Cranial defect position, pulp cavity congestion effects repairing effect.Particularly with adding biology not phase
Bioceramic prepared by the porogen of capacitive, pottery is internal to be needed to connect guarantee completely in sintering process
Porogen is completely exhausted out outside pottery embryo.
Summary of the invention
In place of solving the shortcoming and defect of prior art, the primary and foremost purpose of the present invention is to provide a kind of tool
There is the preparation method of the bionical bioceramic of through hole structure.
Another object of the present invention is to provide a kind of, by what above-mentioned preparation method prepared, there is through hole knot
The bionical bioceramic of structure.
It is still another object of the present invention to provide the application of the above-mentioned bionical bioceramic with through hole structure.
The object of the invention is achieved through the following technical solutions:
A kind of preparation method of the bionical bioceramic with through hole structure, including following operating procedure:
(1) preparation of mould: choose length and width or diameter range is 5mm～40mm, a height of 9mm～80mm
The hollow mould main body of upper and lower side opening, die main body upper and lower side opening part is respectively provided with top cover and base plate, mould
The material of preparing that material is zirconia ceramics or aluminium oxide ceramics, top cover and base plate of preparing of tool main body is
Gasifiable material at 300 DEG C, die main body, top cover and base plate three surround mold cavity, die main body and the end
Plate can realize being tightly connected, and selects the through filament of hard of a diameter of 300～500 μm, by through filament
One end is fixed on base plate, and the other end extends to top cover in mold cavity, and through filament is spaced 700
μm～1mm；
(2) preparation of plastics porous support: by the organic plastics granule of a diameter of 100 μm～500 μm from
It is filled at die main body upper end open in the mold cavity being provided with through filament, adds organic solvent or add
Heat makes organic plastics particle surface dissolve or fusing, it is achieved the mutual bonding between organic plastics granule, then
The organic plastics granule mutually bondd is taken out together with base plate and through filament from mold cavity, uses distilled water
Rinse cooling, obtain the plastics porous support being fixed on base plate and through filament after drying；
(3) bioceramic molding: plastics porous support is reloaded mould together with base plate and through filament
Tool intracavity, then places it on reciprocating sieve, particle diameter is less than the biological ceramic powder of 5 μm from die main body
Add on plastics porous support at upper end open, make biological ceramic powder be full of plastics porous by reciprocating sieve vibration
The hole of support, is then placed on centrifuge centrifugal 5 minutes, adds binding agent and is centrifuged 1 minute
Overall to the mould containing pottery idiosome, the mould entirety containing pottery idiosome is put into drying baker, and to be dried 24 little
Time, then remove through filament putting it into sintering furnace is warming up to 300 DEG C of burn off plastics porous supports,
Top cover and base plate, then be warming up to 900～1200 DEG C and sinter 12 hours, removing die main body obtains having through
The bionical bioceramic of pore structure.
Also set up horizontal through filament on described die main body to be connected with through filament fixing on base plate
Connect, form three-dimensional netted communicating structure.
The cross section of described die main body is circular, square, rectangle or triangle.
Described through filament is aciculiform or S-shaped, and the cross section of through filament is circular, square, length
Square or triangle.
Described through filament with the fixed form of base plate is: be distributed on base plate and through filament cross section
The aperture that form and dimension is identical, through filament is fixed by inserting aperture.
At described 300 DEG C, gasifiable material is polyethylene, polypropylene or makrolon material.
Described organic plastics granule is polyformaldehyde granule, ABS plastic granule, polyethylene terephthalate
One in granule and polycarbonate pellets.
Described organic solvent is acetic acid, Hexafluoro acetone or acetone.
Described biological ceramic powder is hydroxylapatite powder, type alpha tricalcium phosphate (α-TCP) powder, bata-tricalcium phosphate
At least one in (β-TCP) powder, polyphosphoric acid calcium powder and tetracalcium phosphate powder.
Described binding agent is Polyethylene Glycol, polyvinyl alcohol or acrylate copolymer.
The material of preparing of described through filament is metal material, removes the side of through filament in step (3)
Formula is that machinery is extracted.
Described through filament prepare material can also with mould top cover or base plate to prepare material identical, step
(3) remove the mode of through filament suddenly for putting in sintering furnace on 300 DEG C and plastics porous support, top
Lid and bottom plate burn off together.
A kind of bionical bioceramic with through hole structure prepared by above-mentioned preparation method.Gained has
The bionical bioceramic having through hole structure can prepare different knot by the shape of through filament or distribution
The through hole of structure.
The above-mentioned bionical bioceramic with through hole structure the replacing of spongy bone in medical domain or veterinary applications
Application in generation reparation or tissue engineering bracket.
Preparation method and obtained product by the present invention have the advantage that and beneficial effect:
(1) present invention is by the design of through hole in bioceramic body, can realize the quick reparation to Cranial defect.
For use stable in fixing and Cranial defect gap more than in the case of 0.1mm, bone marrow stem cell is to lead most
The repair cell wanted.Although the different types of Bone Defect Repari different cell of employing and tissue, but final bone
Synthesis is still by mesenchyme osteoblast and/or surface osteoblast and braided substrate and/or stratiform substrate
Formed, so the working cell of Bone Defect Repari engineering is osteoblast.Assuming that for the Cranial defect of certain case-specific
In, a composition osteocyte is certain for the action effect of Bone Defect Repari, then the repairing effect of Cranial defect depends on
In the osteoblastic how many and distribution acting on this reparation district.Osteoblastic how much depend on Bone Defect Repari material
Expecting the adhesive attraction for bone marrow stem cell and differentiation, material internal structure is depended in osteoblastic distribution.
The adhesion being designed with beneficially bone marrow stem cell of the through hole in the present invention and bone marrow stem cell are whole imitative
Being uniformly distributed in raw bioceramic, simultaneously facilitates transport and the cellular metabolism of nutrient substance.
(2) the bionical bioceramic with through hole structure of the present invention can be used for the replacement reparation of spongy bone.
The spongy bone of human body is between 30% to 90%.Contradiction is there is between bioceramic porosity and mechanical strength,
Bioceramic porosity height then mechanical strength is relatively low, and the low then mechanical strength of bioceramic porosity is higher.Due to
The nonweight-bearing position of human body need not the biggest mechanical strength and supports, so the present invention passes through from bionical angle
Control the diameter of through hole and density produces the bioceramic that porosity is 60% to 90%, can be used to
Join different Cranial defect positions.
(3) the bionical bioceramic with through hole structure of the present invention can prop up as good organizational project
Frame.Owing to the bionical bioceramic structure of the present invention has good connectivity, blood fortune can arrive ceramic material
Each position so that be attached on ceramic material the bone marrow stem cell at each position all can normal growth, no
There will be internal downright bad situation.
(4) production technology of the present invention uses vibration and centrifugal step just can prepare and with plastics porous support be
The ceramic idiosome of porogen, compared to existing technology in by being configured to the slurry filling of ceramic powder and water to many
Method in the timbering material of hole, this technique can avoid the pollution of trace element in the dispersant of water and serosity,
It is greatly saved preparation and the cost of detection purified water simultaneously, and can be realized greatly by the optimization of technological parameter
Large-scale production.
(5), during prior art prepares the technique of bioceramic, during porogen gasifies, it is easily caused pottery
The bending of porcelain idiosome fractures；This technique substantially increases product by die main body to the effect of contraction of pottery idiosome
Qualification rate, simultaneously in the burn off in sintering furnace and sintering process, pottery idiosome can shrink and die main body is big
Little constant, certain gap can be produced between pottery idiosome and die main body, thus ensure that porogen can be complete
Full gasification.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention do not limit
In this.
Embodiment 1
The preparation method of a kind of bionical bioceramic with through hole structure of the present embodiment, including following behaviour
Make step:
(1) preparation of mould: selecting internal diameter is 20 millimeters, the cylinder mold main body of a height of 80 millimeters and
Associated top cover and base plate, die main body prepare the system that material is zirconia ceramics, top cover and base plate
Standby material is polyethylene, and die main body, top cover and base plate three surround mold cavity, and on base plate, fixed diameter is
500 microns, spacing distance be the aciculiform cylindrical metal silk of 1 millimeter, tinsel extends to top in mold cavity
Lid；
(2) preparation of plastics porous support: by the ABS plastic granule of a diameter of 300 μm～400 μm from
Die main body upper end open is filled in mold cavity, puts into 180 DEG C of baking oven and heats 30 minutes, makes ABS mould
Material particle surface fusing mutually bonding, then by the ABS plastic granule that mutually bonds together with base plate and tinsel
In die cavity, taking-up distilled water cools down, and is then dried to obtain the plastics porous being fixed on base plate and tinsel
Support；
(3) bioceramic molding: plastics porous support is reloaded mold cavity together with base plate and tinsel
In, then place it on reciprocating sieve, 78g particle diameter is less than the β-TCP powder of 5 μm from mould upper end
Opening part adds on plastics porous support, makes α-TCP powder be full of plastics porous support by reciprocating sieve vibration
Hole, is then placed on centrifuge centrifugal 5 minutes, adds 3.2g Polyethylene Glycol binding agent, centrifugal
Within 1 minute, obtain the mould containing pottery idiosome overall, the mould entirety containing pottery idiosome is put into drying baker and does
Dry 24 hours, then extract through filament putting it in sintering furnace and be warmed up to 1 DEG C/min speed
300 DEG C of burn off plastics porous supports, top cover and base plate, be then warmed up to 1200 DEG C of sintering 12 with 5 DEG C/min
Individual hour, removing die main body obtained the bionical bioceramic with through hole structure.
Embodiment 2
The preparation method of a kind of bionical bioceramic with through hole structure of the present embodiment, including following operation
Step:
(1) preparation of mould: select a length of 31.4 millimeters, a width of 10 millimeters a height of 18 millimeters rectangular
Mould main body and associated top cover and base plate, the material of preparing of die main body is zirconia ceramics, top
The material of preparing of lid and bottom plate is polypropylene, and die main body, top cover and base plate three surround mold cavity, base plate
The aciculiform cylindric polyethylene hard silk that upper fixed diameter is 300 microns, spacing distance is 700 microns, firmly
Matter silk extends to top cover in mold cavity.
(2) preparation of plastics porous support: the ABS plastic granule of a diameter of 200 μm～300 μm is filled out
Enter in mold cavity, add acetone, make ABS plastic particle surface dissolve mutually bonding, use distilled water flushing
Fall acetone, then the ABS plastic granule mutually bondd is taken together with base plate and polyethylene hard silk in die cavity
Go out and be dried to obtain the plastics porous support being fixed on base plate and polyethylene hard silk.
(3) bioceramic molding: plastics porous support is reloaded together with base plate and polyethylene hard silk
In mold cavity, then place it on reciprocating sieve, 4.4g particle diameter is less than the β-TCP powder of 5 μm from mould
Add on plastics porous support at tool upper end open, make β-TCP powder be full of plastics porous by reciprocating sieve vibration
The hole of support, is then placed on centrifuge centrifugal 5 minutes, adds 0.2g polyvinyl alcohol adhesive,
Obtain the mould containing pottery idiosome after centrifugal 1 minute overall, will put into containing the mould entirety of pottery idiosome
Drying baker is dried 24 hours, then puts it in sintering furnace and is warmed up to 300 DEG C of burn offs with 1 DEG C/min speed
Plastics porous support, top cover, base plate and hard silk, be then warmed up to 1150 DEG C with 5 DEG C/min and sinter 12
Hour, removing die main body obtains the bionical bioceramic with through hole structure.
Embodiment 3
The preparation method of a kind of bionical bioceramic with through hole structure of the present embodiment, including following operation
Step:
(1) preparation of mould: selecting the length of side is the square die main body of 24 millimeters and associated top
Lid and bottom plate, the material of preparing that material is aluminium oxide ceramics, top cover and base plate of preparing of die main body is poly-third
Alkene, die main body, top cover and base plate three surround mold cavity, and on base plate, fixed diameter is 500 micron,
Spacing from for the S-shaped cylindric polypropylene hard silk of 1 millimeter, hard silk extends to top cover in mold cavity.
(2) preparation of plastics porous support: the polycarbonate pellets of a diameter of 400 μm～500 μm is filled out
Enter in mold cavity, add acetone, make polycarbonate pellets surface dissolve mutually bonding, use distilled water flushing
Fall acetone, then the polycarbonate pellets mutually bondd is taken together with base plate and polypropylene hard silk in die cavity
Go out and be dried to obtain the plastics porous support being fixed on base plate and polypropylene hard silk.
(3) bioceramic molding: plastics porous support is reloaded together with base plate and polypropylene hard silk
In mold cavity, then place it on reciprocating sieve, 11g particle diameter is less than the polyphosphoric acid calcium powder of 5 μm from mould
Add on plastics porous support at tool upper end open, make polyphosphoric acid calcium powder be full of plastics by reciprocating sieve vibration many
The hole of hole support, is then placed on centrifuge centrifugal 5 minutes, adds 0.5g acrylate copolymer
Binding agent, the mould that after centrifugal 1 minute, top cover obtains containing pottery idiosome is overall, will be containing pottery embryo
The mould entirety of body is put into drying baker and is dried 24 hours, then puts it in sintering furnace with 1 DEG C/min speed
It is warmed up to 300 DEG C of burn off plastics porous supports, top cover, base plate and hard silk, is then warmed up to 5 DEG C/min
900 DEG C sinter 12 hours, and removing die main body obtains the bionical bioceramic with through hole structure.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-mentioned reality
Execute the restriction of example, the change made under other any spirit without departing from the present invention and principle, modification,
Substitute, combine, simplify, all should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (10)
1. the preparation method of a bionical bioceramic with through hole structure, it is characterised in that: include with
Lower operating procedure:
(1) preparation of mould: choose length and width or diameter range is 5mm～40mm, a height of 9mm～80mm
The hollow mould main body of upper and lower side opening, die main body upper and lower side opening part is respectively provided with top cover and base plate, mould
The material of preparing that material is zirconia ceramics or aluminium oxide ceramics, top cover and base plate of preparing of tool main body is
Gasifiable material at 300 DEG C, die main body, top cover and base plate three surround mold cavity, die main body and the end
Plate can realize being tightly connected, and selects the through filament of hard of a diameter of 300～500 μm, by through filament
One end is fixed on base plate, and the other end extends to top cover in mold cavity, and through filament is spaced 700
μm～1mm；
(2) preparation of plastics porous support: by the organic plastics granule of a diameter of 100 μm～500 μm from
It is filled at die main body upper end open in the mold cavity being provided with through filament, adds organic solvent or add
Heat makes organic plastics particle surface dissolve or fusing, it is achieved the mutual bonding between organic plastics granule, then
The organic plastics granule mutually bondd is taken out together with base plate and through filament from mold cavity, uses distilled water
Rinse cooling, obtain the plastics porous support being fixed on base plate and through filament after drying；
(3) bioceramic molding: plastics porous support is reloaded mould together with base plate and through filament
Tool intracavity, then places it on reciprocating sieve, particle diameter is less than the biological ceramic powder of 5 μm from die main body
Add on plastics porous support at upper end open, make biological ceramic powder be full of plastics porous by reciprocating sieve vibration
The hole of support, is then placed on centrifuge centrifugal 5 minutes, adds binding agent and is centrifuged 1 minute
Overall to the mould containing pottery idiosome, the mould entirety containing pottery idiosome is put into drying baker, and to be dried 24 little
Time, then remove through filament putting it into sintering furnace is warming up to 300 DEG C of burn off plastics porous supports,
Top cover and base plate, then be warming up to 900～1200 DEG C and sinter 12 hours, removing die main body obtains having through
The bionical bioceramic of pore structure.
The preparation method of a kind of bionical bioceramic with through hole structure the most according to claim 1,
It is characterized in that: on described die main body, also set up the through silk that horizontal through filament is fixing with on base plate
Shape thing is connected, and forms three-dimensional netted communicating structure.
The preparation of a kind of bionical bioceramic with through hole structure the most according to claim 1 and 2
Method, it is characterised in that: the cross section of described die main body is circular, rectangle or triangle；Described pass through
Logical filament is aciculiform or S-shaped, and the cross section of through filament is circular, rectangle or triangle.
The preparation of a kind of bionical bioceramic with through hole structure the most according to claim 1 and 2
Method, it is characterised in that: described through filament with the fixed form of base plate is: is distributed on base plate and passes through
Logical filament shape of cross section and the identical aperture of size, through filament is fixed by inserting aperture.
The preparation of a kind of bionical bioceramic with through hole structure the most according to claim 1 and 2
Method, it is characterised in that: at described 300 DEG C, gasifiable material is polyethylene, polypropylene or Merlon material
Material；Described organic plastics granule is polyformaldehyde granule, ABS plastic granule, polyethylene terephthalate
Granule or polycarbonate pellets；Described organic solvent is acetic acid, Hexafluoro acetone or acetone.
The preparation of a kind of bionical bioceramic with through hole structure the most according to claim 1 and 2
Method, it is characterised in that: described biological ceramic powder is hydroxylapatite powder, type alpha tricalcium phosphate powder, β-phosphoric acid
At least one in three calcium powders, polyphosphoric acid calcium powder and tetracalcium phosphate powder；Described binding agent is Polyethylene Glycol, gathers
Vinyl alcohol or acrylate copolymer.
The preparation of a kind of bionical bioceramic with through hole structure the most according to claim 1 and 2
Method, it is characterised in that: the material of preparing of described through filament is metal material, removes in step (3)
The mode of through filament is that machinery is extracted.
The preparation of a kind of bionical bioceramic with through hole structure the most according to claim 1 and 2
Method, it is characterised in that: described through filament prepare material and mould top cover or base plate prepare material
Identical, the mode removing through filament in step (3) is warming up to 300 DEG C and plastics for putting in sintering furnace
Porous support, top cover burn off together with base plate.
9. a bionical bioceramic with through hole structure, it is characterised in that: by claim 1～8
One described preparation method prepares.
10. a kind of bionical bioceramic with through hole structure described in claim 9 is led in preparation medical science
The application substituted in repair materials or tissue engineering bracket of spongy bone in territory or veterinary applications.
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| CN108452385B (en) * | 2017-02-17 | 2020-07-03 | 重庆润泽医药有限公司 | Porous material |
| CN108452384B (en) * | 2017-02-17 | 2020-09-15 | 重庆润泽医药有限公司 | Porous material |
| CN108452386B (en) * | 2017-02-17 | 2020-09-15 | 重庆润泽医药有限公司 | Porous material |
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| CN107190571A (en) * | 2017-04-27 | 2017-09-22 | 舒尔环保科技（合肥）有限公司 | A kind of new ceramics fiber air scavenging material and preparation method |
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