CN104587344A - Prescription for tonifying kidney and spleen in patients with hyperthyroidism and preparation method of prescription - Google Patents

Abstract

The invention discloses a prescription for tonifying kidney and spleen in patients of hyperthyroidism. The prescription is mainly prepared from the following crude medicines in parts by weight: 10-20 parts of fried wild jujube seeds, 9-15 parts of herba cistanche, 8-15 parts of cape jasmine fruit, 8-12 parts of seed of Chinese dodder, 5-10 parts of rhizoma pinelliae preparata, 8-14 parts of thunberg fritillary bulb, 6-9 parts of seaweed, 9-14 parts of oyster, 10-20 parts of angelica, 10-20 parts of raspberry, 12-25 parts of fermented soybean, 9-18 parts of cuttlebone, 8-16 parts of rhizoma galangae, 3-6 parts of thunder god vine, 3-6 parts of serrate rabdosia herb, 8-12 parts of citrus chirocarpus, 15-20 parts of yam, 15-20 parts of dried orange peel, 8-12 parts of safflower, 9-15 parts of codonopsis pilosula and 6-9 parts of airpotato yam rhizome. The prescription disclosed by the invention follows the theory of traditional Chinese medicine from material selection to preparation, and is scientifically prepared; the prescription is applicable to different groups, and has functions of soothing liver and regulating qi, eliminating dampness and reducing phlegm, dispersing heat and suffocating, calming heart and tranquilizing, and the like; upon clinical tests, the agent prepared by the invention is verified to be safe and effective, significant in curative effect and short in treatment course.

Description

Hyperthyroid kidney and spleen invigorating side and preparation

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of hyperthyroid kidney and spleen invigorating side and preparation.

Background technology

Hyperthyroidism is called for short hyperthyroidism, mean and cause thyroid function to strengthen by many reasons, secretion thyroxin (TH) is too much, and causing the system stimulant such as the nerve of body, circulation and digestion to increase with hypermetabolism is the clinical syndrome of main manifestations.Most hyperthyroidism onset is slow, and also have acute onset, women is common, and the ratio of men and women is about 1: 4 ~ 6.Each age group all can be fallen ill, and it is many for sending out patient with 20 ~ 40 years old.The sickness rate each department of thyroid disease are different, and hyperthyroidism typically refers to hyperfunctioning graves, the most common clinically.The typical clinical manifestation of hyperthyroidism comprises the metabolism that thyroxine too much causes and increases and the large syndrome of neural excitation two.(1) metabolic rate increases: show as bulimia, lose weight, cool To Be Protected from Heat, skin is warm for increased heart rate, fatigue and weak, happiness, moist hyperhidrosis, can also occur the symptom such as sensation of oppression over the chest with shortness of breath, diarrhoea loose stool; (2) neural excitation: often show as nervousness, disposition is nervous, irritable, emotional, insomnia and dreamful sleep.Melancholy, the Mental Subnormality such as manic performance can be there is in the person of being in a bad way.In a word, primary disease diagnosis not difficult, if clinical manifestation be cardiopalmus, spontaneous perspiration, appetite increase lose weight, emotion is emotional, hand shaking, exophthalmos and thyromegaly etc.The basic skills controlling hyperthyroidism disease group is: 1. antithyroid drug; 2. iodine radioisotope; 3. perform the operation.Publication number CN 103505666 A(application number 201210199841.0) Chinese patent literature disclose a kind of Chinese medicine for the treatment of hyperthyroidism, composition Sargassum 28-32 gram, Thallus Laminariae (Thallus Eckloniae) 28-32 gram, Spica Prunellae 28-32 gram, Bulbus Fritillariae Thunbergii 18-22 gram, Rhizoma Sparganii 13-17 gram, Pericarpium Citri Reticulatae Viride 13-17 gram, Rhizoma Atractylodis Macrocephalae 18-22 gram, Herba Dendrobii 18-22 gram, Rhizoma Dioscoreae 18-22 gram, Radix Pseudostellariae 18-22 gram, Radix Rehmanniae Preparata 18-22 gram, Semen Sinapis Albae 10-14 gram.Publication number CN 103505619 A(application number 201210200521.2) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of hyperthyroidism, medical material in compositions has Radix Adenophorae (Radix Glehniae) 13-17 gram, Radix Asparagi 13-17 gram, Radix Scrophulariae 13-17 gram, Radix Rehmanniae 13-17 gram, pollen 13-17 gram, Thallus Laminariae (Thallus Eckloniae) 13-17 gram, Sargassum 13-17 gram, Radix Sophorae Tonkinensis 10-14 gram, Bulbus Fritillariae Thunbergii 8-12 gram, Radix Paeoniae Rubra 10-14 gram.Publication number CN 103040972 A(application number 201210565981.5) Chinese patent literature disclose treatment hyperthyroidism Chinese medicine formula, major ingredient: Spica Prunellae 12 grams, Fructus Forsythiae 12 grams, Fructus Atriplicis Sibiricae 15 grams, Concha Ostreae (calcined) 30 grams, Semen Impatientis 9 grams, Semen Ziziphi Spinosae 15 grams, adjuvant: water 1000ml.

At present, the main or sulfonylurea receptor of the western drug for the treatment of hyperthyroidism, by suppressing the synthesis of thyroxin to play a role, but such courses of pharmaceuticals is long, needs long-term taking, and antithyroid drug consumption improperly words can cause hypothyroidism.Radiotherapy, therapeutic outcome varies with each individual, and radiological dose and individual can have influence on therapeutic outcome to radiation sensitive.Chinese Herbs is stablized, treatment safety, and effective, therefore about research in this respect still needs further effort.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide a kind of determined curative effect, relieved hyperthyroid kidney and spleen invigorating side of taking and preparation method.

Technical scheme of the present invention is:

Hyperthyroid kidney and spleen invigorating side, is prepared from primarily of following bulk drugs, is weight portion: Semen Ziziphi Spinosae (parched) 10-20, Herba Cistanches 9-15, Fructus Gardeniae 8-15, Semen Cuscutae 8-12, Rhizoma Pinelliae 5-10, Bulbus Fritillariae Thunbergii 8-14, Sargassum 6-9, Concha Ostreae 9-14, Radix Angelicae Sinensis 10-20, Fructus Rubi 10-20, Semen Sojae Preparatum 12-25, Endoconcha Sepiae 9-18, Rhizoma Alpiniae Officinarum 8-16, Radix Tripterygii Wilfordii 3-6, Herba Rabdosiae Lophanthoidis 3-6, Fructus Citri Sarcodactylis 8-12, Rhizoma Dioscoreae 15-20, Pericarpium Citri Reticulatae 15-20, Flos Carthami 8-12, Radix Codonopsis 9-15, Rhizoma Dioscoreae Bulbiferae 6-9.

In preferred scheme, Semen Ziziphi Spinosae (parched) 12-18, Herba Cistanches 11-13, Fructus Gardeniae 10-13, Semen Cuscutae 9-11, Rhizoma Pinelliae 6-9, Bulbus Fritillariae Thunbergii 10-12, Sargassum 7-8, Concha Ostreae 10-13, Radix Angelicae Sinensis 12-18, Fructus Rubi 12-18, Semen Sojae Preparatum 15-22, Endoconcha Sepiae 10-17, Rhizoma Alpiniae Officinarum 10-14, Radix Tripterygii Wilfordii 4-5, Herba Rabdosiae Lophanthoidis 4-5, Fructus Citri Sarcodactylis 9-11, Rhizoma Dioscoreae 16-19, Pericarpium Citri Reticulatae 16-19, Flos Carthami 9-11, Radix Codonopsis 11-13, Rhizoma Dioscoreae Bulbiferae 7-8.

Be more preferably, Semen Ziziphi Spinosae (parched) 15, Herba Cistanches 12, Fructus Gardeniae 11.5, Semen Cuscutae 10, Rhizoma Pinelliae 7.5, Bulbus Fritillariae Thunbergii 11, Sargassum 7.5, Concha Ostreae 11.5, Radix Angelicae Sinensis 15, Fructus Rubi 15, Semen Sojae Preparatum 18.5, Endoconcha Sepiae 13.5, Rhizoma Alpiniae Officinarum 12, Radix Tripterygii Wilfordii 4.5, Herba Rabdosiae Lophanthoidis 4.5, Fructus Citri Sarcodactylis 10, Rhizoma Dioscoreae 17.5, Pericarpium Citri Reticulatae 17.5, Flos Carthami 10, Radix Codonopsis 12, Rhizoma Dioscoreae Bulbiferae 7.5.

The preparation method of described hyperthyroid kidney and spleen invigorating side powder is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder, make medicated powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae and Concha Ostreae are scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder, obtained medicamental pulverata;

(4) by other crude drug except Fructus Gardeniae, Herba Cistanches, Endoconcha Sepiae and Concha Ostreae, decontamination, cleans, slightly soak, be placed in pot to steam, take out, after cooling, be placed in baking oven, dry, pulverize and sieve together with step (2) made crude drug, with step (1) (3) made medicated powder and medicamental pulverata, mixing, obtains powder.

The preparation method of described hyperthyroid kidney and spleen invigorating side powder, step (4) is placed in pot and steams 20-40 minute (preferably, steaming 25-35 minute; Be more preferably, steam 30 minutes).

The preparation method of described pill is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder, make medicated powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae and Concha Ostreae are scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder, obtained medicamental pulverata;

(4) by other crude drug except Fructus Gardeniae, Herba Cistanches, Endoconcha Sepiae and Concha Ostreae, decontamination, cleans, slightly soak, be placed in pot to steam, take out, after cooling, be placed in baking oven, dry, pulverize and sieve together with step (2) made crude drug, with step (1) (3) made medicated powder and medicamental pulverata, mixing, makes mixed powder;

(5) by step (4) made mixed powder, mix with refined honey water, generally make honeyed pill, obtain pill.

The preparation method of described hyperthyroid kidney and spleen invigorating side pill, in step (5) refined honey water, the mass ratio of refined honey and water is that 1:3-1:5(is preferred, and the mass ratio of refined honey and water is 1:4).

The preparation method of described granule is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae is scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder;

(4) remove the Rhizoma Pinelliae after impurity, Bulbus Fritillariae Thunbergii and Concha Ostreae and be placed in pot, add water and do not have crude drug, decoct 20 minutes, add Semen Ziziphi Spinosae (parched), Semen Cuscutae, Sargassum, Radix Angelicae Sinensis, Fructus Rubi, Semen Sojae Preparatum, Rhizoma Alpiniae Officinarum, Radix Tripterygii Wilfordii, Herba Rabdosiae Lophanthoidis, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Flos Carthami, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and step (2) made crude drug, add water and do not have medical material 3cm, soak 30 minutes;

(5) be heated to boiling, then simmer in water that (preferred, simmered in water 35-45 minute in 30-50 minute; Be more preferably, simmer in water 40 minutes), filter, collect filtrate, remaining filtering residue will be filtered and again decoct, filter, merge twice filtrate, step (1) (3) made medicated powder and medicamental pulverata are added in filtrate, stirs, spraying dry, pulverizes, mixes with pharmaceutical excipients, make soft material, granulate, 60-70 DEG C of drying, granulate, obtains granule.

The preparation method of described hyperthyroid kidney and spleen invigorating side granule, the time that step (5) filtering residue decocts again is that (preferred, the time that filtering residue decocts again was 45-55 minute in 40-60 minute; Be more preferably, the time that filtering residue decocts again is 50 minutes).

The preparation method of described decoction is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, Fructus Gardeniae ground into powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae is scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder;

(4) remove the Rhizoma Pinelliae after impurity, Bulbus Fritillariae Thunbergii and Concha Ostreae and be placed in pot, add water and do not have crude drug, decoct 20 minutes, add Semen Ziziphi Spinosae (parched), Semen Cuscutae, Sargassum, Radix Angelicae Sinensis, Fructus Rubi, Semen Sojae Preparatum, Rhizoma Alpiniae Officinarum, Radix Tripterygii Wilfordii, Herba Rabdosiae Lophanthoidis, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Flos Carthami, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and step (2) made crude drug, add water and do not have medical material 3cm, soak 30 minutes;

(5) be heated to boiling, then simmer in water, filter, step (1) (3) made medicated powder and medicamental pulverata are added wherein, stirs, obtain decoction.

The preparation method of described hyperthyroid kidney and spleen invigorating side decoction, step (5) simmers in water again, and within 30-50 minute, (preferred, simmer in water 35-45 minute; Be more preferably, simmer in water 40 minutes).

Hyperthyroid kidney and spleen invigorating side provided by the invention, multiple dosage form preparation method is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:

1, the present invention is from selection to preparation, follows theory of Chinese medical science, and science is formulated, can effective patients in remission;

2, this prescription is applicable to different crowd, has depressed liver-energy dispersing and QI regulating, the effect such as drying dampness to eliminate phlegm, a surname send out hot and suffocating, mind tranquilizing and the heart calming;

3, the made medicament of the present invention is through verification experimental verification, safe and effective, evident in efficacy, and short treating period.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1hyperthyroid kidney and spleen invigorating side, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Ziziphi Spinosae (parched) 10 parts, Herba Cistanches 9 parts, Fructus Gardeniae 8 parts, Semen Cuscutae 8 parts, Rhizoma Pinelliae 5 parts, Bulbus Fritillariae Thunbergii 8 parts, Sargassum 6 parts, Concha Ostreae 9 parts, Radix Angelicae Sinensis 10 parts, Fructus Rubi 10 parts, Semen Sojae Preparatum 12 parts, Endoconcha Sepiae 9 parts, Rhizoma Alpiniae Officinarum 8 parts, Radix Tripterygii Wilfordii 3 parts, Herba Rabdosiae Lophanthoidis 3 parts, Fructus Citri Sarcodactylis 8 parts, Rhizoma Dioscoreae 15 parts, Pericarpium Citri Reticulatae 15 parts, 8 parts, Flos Carthami, Radix Codonopsis 9 parts, Rhizoma Dioscoreae Bulbiferae 6 parts.

The preparation method of above-mentioned hyperthyroid kidney and spleen invigorating side powder is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder, make medicated powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae and Concha Ostreae are scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder, obtained medicamental pulverata;

(4) by other crude drug except Fructus Gardeniae, Herba Cistanches, Endoconcha Sepiae and Concha Ostreae, decontamination, cleans, slightly soak, be placed in pot to steam 30 minutes, take out, after cooling, be placed in baking oven, dry, pulverize and sieve together with step (2) made crude drug, with step (1) (3) made medicated powder and medicamental pulverata, mixing, obtains powder.

The instructions of taking of powder of the present invention: powder is 7 days courses for the treatment of, twice daily, each one bag (4-6g), uses warm boiled water.

embodiment 2hyperthyroid kidney and spleen invigorating side, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Ziziphi Spinosae (parched) 20 parts, Herba Cistanches 15 parts, Fructus Gardeniae 15 parts, Semen Cuscutae 12 parts, Rhizoma Pinelliae 10 parts, Bulbus Fritillariae Thunbergii 14 parts, Sargassum 9 parts, Concha Ostreae 14 parts, Radix Angelicae Sinensis 20 parts, Fructus Rubi 20 parts, Semen Sojae Preparatum 25 parts, Endoconcha Sepiae 18 parts, Rhizoma Alpiniae Officinarum 16 parts, Radix Tripterygii Wilfordii 6 parts, Herba Rabdosiae Lophanthoidis 6 parts, Fructus Citri Sarcodactylis 12 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Citri Reticulatae 20 parts, 12 parts, Flos Carthami, Radix Codonopsis 15 parts, Rhizoma Dioscoreae Bulbiferae 9 parts.

The preparation method of hyperthyroid kidney and spleen invigorating side pill is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder, make medicated powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae and Concha Ostreae are scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder, obtained medicamental pulverata;

(4) by other crude drug except Fructus Gardeniae, Herba Cistanches, Endoconcha Sepiae and Concha Ostreae, decontamination, cleans, slightly soak, be placed in pot to steam, take out, after cooling, be placed in baking oven, dry, pulverize and sieve together with step (2) made crude drug, with step (1) (3) made medicated powder and medicamental pulverata, mixing, makes mixed powder;

(5) by step (4) made mixed powder, mix with refined honey water (mass ratio of refined honey and water is 1:4), generally make honeyed pill, obtain pill.

Model case: xxx, female, 36 years old.Main suit: nearly one week, appearance without obvious inducement is had palpitation, the malaise symptoms such as To Be Protected from Heat, hyperhidrosis, appetite increases comparatively before, but figure is day by day become thin, with limb paralysis and thyromegaly, medical check, blood, urine, feces analysis are all without exception, and first merit five checks that display thyroxine (194.27nmmol/L) is higher, is diagnosed as hyperthyroidism.

Take the present embodiment gained hyperthyroid kidney and spleen invigorating side pill, each 4-5, every day 2 times, warm water delivery service, 7 days courses for the treatment of.After taking a course for the treatment of, the nervous malaise symptoms that waits makes moderate progress, after taking two courses for the treatment of, patient's thyromegaly obviously disappears, and malaise symptoms is comparatively close to disappear, after taking four courses for the treatment of, patient is without malaise symptoms, thyroid disappears substantially, and after taking six courses for the treatment of, patient's thyroid is subsided a swelling completely, before weight recovery to morbidity, hospital checks, and every physico-chemical examination is all normal, and patient fully recovers.

embodiment 3hyperthyroid kidney and spleen invigorating side, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Ziziphi Spinosae (parched) 12 parts, Herba Cistanches 11 parts, Fructus Gardeniae 10 parts, Semen Cuscutae 9 parts, Rhizoma Pinelliae 6 parts, Bulbus Fritillariae Thunbergii 10 parts, Sargassum 7 parts, Concha Ostreae 10 parts, Radix Angelicae Sinensis 12 parts, Fructus Rubi 12 parts, Semen Sojae Preparatum 15 parts, Endoconcha Sepiae 10 parts, Rhizoma Alpiniae Officinarum 10 parts, Radix Tripterygii Wilfordii 4 parts, Herba Rabdosiae Lophanthoidis 4 parts, Fructus Citri Sarcodactylis 9 parts, Rhizoma Dioscoreae 16 parts, Pericarpium Citri Reticulatae 16 parts, 9 parts, Flos Carthami, Radix Codonopsis 11 parts, Rhizoma Dioscoreae Bulbiferae 7 parts.

The preparation method of hyperthyroid kidney and spleen invigorating side granule is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae is scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder;

(4) remove the Rhizoma Pinelliae after impurity, Bulbus Fritillariae Thunbergii and Concha Ostreae and be placed in pot, add water and do not have crude drug, decoct 20 minutes, add Semen Ziziphi Spinosae (parched), Semen Cuscutae, Sargassum, Radix Angelicae Sinensis, Fructus Rubi, Semen Sojae Preparatum, Rhizoma Alpiniae Officinarum, Radix Tripterygii Wilfordii, Herba Rabdosiae Lophanthoidis, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Flos Carthami, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and step (2) made crude drug, add water and do not have medical material 3cm, soak 30 minutes;

(5) be heated to boiling, then simmer in water 40 minutes, filter, collect filtrate, remaining filtering residue will be filtered and again decoct 50 minutes, filter, merge twice filtrate, step (1) (3) made medicated powder and medicamental pulverata are added in filtrate, stirs, spraying dry, pulverizes, mixes with pharmaceutical excipients, make soft material, granulate, 60-70 DEG C of drying, granulate, obtains granule.

Model case: xxx, man, 50 years old.Before 4 years, there is the malaise symptoms such as cardiopalmus, hand tremor, agitation, lassitude and weak, loose stool, medical check, thyromegaly, is diagnosed as hyperthyroidism, after take the pharmaceutical treatments such as thyroid tablet more than a year,, nearest 3 days, once more there is the symptoms such as cardiopalmus, loose stool, hand tremor in stable disease, on inspection, hyperthyroidism recurrence is diagnosed as.

Take the present embodiment gained hyperthyroid kidney and spleen invigorating side granule, adopt twice daily, each one bag (5-7g), with warm boiled water, 7 days courses for the treatment of.After taking two weeks, the uncomfortable disease symptoms such as patient's cardiopalmus alleviate, after taking one month, patient mental is good, and the symptom that feels uneasy disappears substantially, and thyroid reduces, take after two months, patient's malaise symptoms disappears completely, and thyroid, without enlargement, is checked, health indices is all normal, patient fully recovers, and follow up a case by regular visits in two years, patient is not recurred.

embodiment 4hyperthyroid kidney and spleen invigorating side, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Ziziphi Spinosae (parched) 18 parts, Herba Cistanches 13 parts, Fructus Gardeniae 13 parts, Semen Cuscutae 11 parts, Rhizoma Pinelliae 9 parts, Bulbus Fritillariae Thunbergii 12 parts, Sargassum 8 parts, Concha Ostreae 13 parts, Radix Angelicae Sinensis 18 parts, Fructus Rubi 18 parts, Semen Sojae Preparatum 22 parts, Endoconcha Sepiae 17 parts, Rhizoma Alpiniae Officinarum 14 parts, Radix Tripterygii Wilfordii 5 parts, Herba Rabdosiae Lophanthoidis 5 parts, Fructus Citri Sarcodactylis 11 parts, Rhizoma Dioscoreae 19 parts, Pericarpium Citri Reticulatae 19 parts, 11 parts, Flos Carthami, Radix Codonopsis 13 parts, Rhizoma Dioscoreae Bulbiferae 8 parts.

The preparation method of hyperthyroid kidney and spleen invigorating side decoction is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, Fructus Gardeniae ground into powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae is scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder;

(4) remove the Rhizoma Pinelliae after impurity, Bulbus Fritillariae Thunbergii and Concha Ostreae and be placed in pot, add water and do not have crude drug, decoct 20 minutes, add Semen Ziziphi Spinosae (parched), Semen Cuscutae, Sargassum, Radix Angelicae Sinensis, Fructus Rubi, Semen Sojae Preparatum, Rhizoma Alpiniae Officinarum, Radix Tripterygii Wilfordii, Herba Rabdosiae Lophanthoidis, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Flos Carthami, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and step (2) made crude drug, add water and do not have medical material 3cm, soak 30 minutes;

(5) be heated to boiling, then simmer in water 40 minutes, filter, step (1) (3) made medicated powder and medicamental pulverata are added wherein, stirs, obtain decoction.

Model case: xxx, man, 47 years old.The year before without the appearance hyperhidrosis of obvious inducement, dysphoria with feverish sensation in the chest palms and soles, binocular dryness, malaise, symptom such as stool frequency etc., patient thinks to stay up late and gets angry made, has a rest several days, malaise symptoms slightly takes a turn for the better, do not pay attention to, over nearly three months, malaise symptoms increases the weight of, cervical region and upper breast mild consistent distending pain, build is become thin, medical check, diagnosis hyperthyroidism.

Take the present embodiment gained hyperthyroid kidney and spleen invigorating side decoction upon somebody's introduction, adopt twice daily, each 60-100ml(is warm), 7 days courses for the treatment of.After taking two courses for the treatment of, the malaise symptoms such as patient's hyperhidrosis take a favorable turn, and after taking one month, patient's malaise symptoms disappears substantially, cervical region and upper breast distending pain disappear, two courses for the treatment of of consolidate curative effect, and patient checks, health indices is all normal, and follow up a case by regular visits in two years, patient is not recurred.

embodiment 5hyperthyroid kidney and spleen invigorating side, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Ziziphi Spinosae (parched) 15 parts, Herba Cistanches 12 parts, Fructus Gardeniae 11.5 parts, Semen Cuscutae 10 parts, Rhizoma Pinelliae 7.5 parts, Bulbus Fritillariae Thunbergii 11 parts, Sargassum 7.5 parts, Concha Ostreae 11.5 parts, Radix Angelicae Sinensis 15 parts, Fructus Rubi 15 parts, Semen Sojae Preparatum 18.5 parts, Endoconcha Sepiae 13.5 parts, Rhizoma Alpiniae Officinarum 12 parts, Radix Tripterygii Wilfordii 4.5 parts, Herba Rabdosiae Lophanthoidis 4.5 parts, Fructus Citri Sarcodactylis 10 parts, Rhizoma Dioscoreae 17.5 parts, Pericarpium Citri Reticulatae 17.5 parts, 10 parts, Flos Carthami, Radix Codonopsis 12 parts, Rhizoma Dioscoreae Bulbiferae 7.5 parts.

The preparation method of hyperthyroid kidney and spleen invigorating side powder is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder, make medicated powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae and Concha Ostreae are scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder, obtained medicamental pulverata;

(4) by other crude drug except Fructus Gardeniae, Herba Cistanches, Endoconcha Sepiae and Concha Ostreae, decontamination, cleans, slightly soak, be placed in pot to steam 30 minutes, take out, after cooling, be placed in baking oven, dry, pulverize and sieve together with step (2) made crude drug, with step (1) (3) made medicated powder and medicamental pulverata, mixing, obtains powder.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Semen Ziziphi Spinosae (parched): base is former: be the dry mature seed of Rhamnaceae plant Ziziphi Spinosae.Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in pot to fry with slow fire and to heave to crust and be micro-yellow, taking-up, cools.Nature and flavor: sweet, sour are flat.Gui Jing: return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.

Herba Cistanches: base is former: be the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche.Nature and flavor: sweet, salty, temperature.Gui Jing: return kidney, large intestine channel.Function cures mainly: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.

Fructus Gardeniae: base is former: be the fruit of Maguireothamnus speciosus Fructus Gardeniae.Nature and flavor: bitter, cold.Gui Jing: GUIXIN, lung, tri-jiao channel.Function cures mainly: fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

Semen Cuscutae: base is former: be the seed of convolvulus cuscuta plant or cuscuta japonica Choisy.Nature and flavor: sweet, temperature.Gui Jing: return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.

Rhizoma Pinelliae: base is former: be the dry tuber of the aroid Rhizoma Pinelliae.Rhizoma Pinelliae: get and pick the clean Rhizoma Pinelliae, is dipped to after mouth tastes slightly spicy sense according to the method under above-mentioned Rhizoma Pinelliae Preparatum item, adds Alumen well-done altogether with water, taking-up, dries in the air to sixty percent dry, cuts into slices, dry after moistening.Nature and flavor: pungent, temperature; Poisonous.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.

Bulbus Fritillariae Thunbergii: base is former: be the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii.Nature and flavor: bitter, cold.Gui Jing: return lung, heart channel.Function cures mainly: heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing, for wind-heat invading the lung, and phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.

Sargassum: base is former: be the dry frond of Sargassaceae plant Sargassum or Sargassum fusiforme (Harv.) Setch.Nature and flavor: bitter, salty, cold.Gui Jing: return liver, stomach, kidney channel.Function cures mainly: hard masses softening and resolving, expectorant, diuretic.For goiter, scrofula, painful and swollen testis, phlegm retention edema.

Concha Ostreae: base is former: the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.Nature and flavor: salty, are slightly cold.Gui Jing: return liver, gallbladder, kidney channel.Function cures mainly: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Radix Angelicae Sinensis: base is former: be the dry root of umbelliferae angelica.Nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Fructus Rubi: base is former: be the dry fruit of Rosaceae rubus rubus chingii Hu.Nature and flavor: sweet, sour, temperature.Gui Jing: return kidney, urinary bladder channel.Function cures mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.

Semen Sojae Preparatum: base is former: for the seed of legume soybean processes through steaming net for catching birds or fish.Nature and flavor: bitter, pungent, cool.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: induce sweat, relieving restlessness, and a surname sends out hot and suffocating.For flu, cold and heat headache, fidgety uncomfortable in chest, restlessness of asrhenia type and insomnia.

Endoconcha Sepiae: base is former: be the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish.Nature and flavor: salty, puckery, temperature.Gui Jing: return spleen, kidney channel.Function cures mainly: astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.

Rhizoma Alpiniae Officinarum: base is former: be the dry rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum.Nature and flavor: pungent, heat.Gui Jing: return spleen, stomach warp.Function cures mainly: warming stomach for dispelling cold, and help digestion pain relieving.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.

Radix Tripterygii Wilfordii: base is former: be root, the Ye Jihua of Celastraceae plant Radix Tripterygii Wilfordii.Nature and flavor: bitter, pungent, cool.Very toxic.Function cures mainly: dispel the wind, removing toxic substances, parasite killing.External treating rheumatic arthritis, skin is itched, and kills maggot, wriggler, water-snail eradication, malicious Mus.

Herba Rabdosiae Lophanthoidis: base is former: be the herb of labiate Rabdosia lophanthoides.Nature and flavor: bitter, cold.Gui Jing: return liver; Gallbladder; Large intestine channel.Function cures mainly: clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.For acute icterohepatitis, acute cholecystitis, enteritis, dysentery, treating swelling and pain by traumatic injury.

Fructus Citri Sarcodactylis: base is former: be the fruit of rutaceae Fructus Citri Sarcodactylis.Nature and flavor: pungent; Bitter; Temperature.Gui Jing: liver; Stomach; Spleen; Lung meridian.Function cures mainly: liver-smoothing, qi-regulating; Stomach function regulating reduces phlegm.Hypochondriac pain, the breast of main depression of liver-QI are vexed; The abdominal distention of incoordination between the liver and stomach, stagnation of QI in spleen and stomach, heating installation, to feel sick; Chronic cough abundant expectoration.

Rhizoma Dioscoreae: base is former: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Pericarpium Citri Reticulatae: base is former: be the dry mature skin of rutaceae orange and variety thereof.Nature and flavor: bitter, pungent, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Flos Carthami: base is former: be the dried floral of feverfew Flos Carthami.Nature and flavor: pungent, temperature.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.

Radix Codonopsis: base is former: be Campanulaceae Radix Codonopsis, the plain dry root spending Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) or radix codonpsis tangshen.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Rhizoma Dioscoreae Bulbiferae: base is former: the tuber of Dioscoreaceae yam Dioscorea bulbifera L..Nature and flavor: bitter, pungent, cool.Slightly poisonous.Gui Jing: " Bencao Jingshu ": " start with few the moon, meridian of Foot-JUE YIN."。Function cures mainly: removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, cooling blood for hemostasis.For thyromegaly, tuberculous lymphadenitis, laryngopharynx swelling and pain, spits blood, spitting of blood, pertussis, cancerous protuberance; Furuncle is controlled in external.

test example 1the clinical practice of gained hyperthyroid kidney and spleen invigorating side (embodiment 5) of the present invention:

In February ,-2014 in February, 2012, in the patient of 6 hospital's department of endocrinology outpatient clinics, filter out 324 examples be diagnosed as hyperthyroid case, wherein women 158 example, male 166 example, age 18-63 year, 35.47 ± 4.13 years old mean age, course of disease 1-5, average course of disease 1.96 ± 0.62 years.Diagnostic criteria: with reference to " new Chinese medicine guideline of clinical investigations ": (1) nervous system anxiety, nervous, emotional, absent minded, insomnia, menoxenia, To Be Protected from Heat, hyperhidrosis, and skin is warm and humid, hand tremor (eye closing, arm are put down when stretching visible); (2) cardiovascular system tachycardia, first heart sound is hyperfunction, and pulse pressure difference increases, visible arrhythmia (premature beat, atrial fibrillation etc.); (3) digestive system bulimia, weight loss, times of defecation increase; (4) thyroid Most patients thyroid is even enlargement, and matter is soft, smooth, has Ni sexy, and without tuberosity, not bitterly, without tenderness, local palpation can feel fine tremor, auscultation audible and vascular murmur; (5) other some patientss companion expophthalmos, small number of patients companion pretibial myxedema.Physico-chemical examination: (1) hormone determination (trilute (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) measured value raise, hypersensitive thyroid stimulating hormone (TSH) measured value reduction or normal); (2) (iodine taking rate increases Thyroid Intaking I functional examination, 3 hours > 25%; Or 24 hours > 45%; Peak value moves forward); (3) thyroid B is super checks (supporting thyroid diffusivity hypertrophy, without obvious tuberosity).

Inclusive criteria: (1) age was at 18 ~ 65 years old; (2) above-mentioned hyperthyroidism diagnostic criteria is met; (3) severity Scaling belongs to light, moderate; (4) darling renal function is normal; (5) without other endocrinopathy; (6) observer of voluntary partner treatment.

Exclusion standard: (1) does not meet above-mentioned inclusive criteria; (2) gestation or women breast-feeding their children, psychotic etc.; (3) severity Scaling belongs to severe; (4) primary diseases such as the heart, Liver and kidney function obstacle and hemopoietic system are merged; (5) hyperthyroidism crisis person, and various thyroiditis; (6) significantly thyromegaly oppresses adjacent organs person; (7) long-term taking Western medicine, can not drug withdrawal person; (8) to this drug allergy person.

Test method: patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, and twice daily, each one bag (4-6g), with warm boiled water, 7 days courses for the treatment of, matched group takes other medicine (conventional medication such as medicine for treating thyreoidism capsule, hyperthyroidism Tablet, levothyroxine sodium tables).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.

Curative effect situation criterion: cure: transference cure, pulse frequency is normal, and body weight increases, and region thyreoidea trembles and vascular murmur disappears, and goiter and expophthalmos are levied and alleviated, and relevant physico-chemical examination recovers normal; Effective: cardinal symptom disappears substantially, pulse frequency is normal, and body weight increases, and region thyreoidea trembles and vascular murmur disappears, and goiter and expophthalmos are levied and alleviated, and relevant physico-chemical examination is normal; Effective: symptom is improved, and pulse frequency slows down, and vascular murmur alleviates, goiter is reduced, and in relevant physico-chemical examination, FT3, FT4 are normal; Invalid: symptom, sign, relevant physico-chemical examination are all without obviously changing.

Table 1 liang component group situation and the patient treatment outcome after two months that takes medicine

Two groups of patient treatment outcome are as shown in table 1, in experimental group, cure 23 examples, effective 63 examples, effective 102 examples, total effectively example 188 example, total effective rate 96.9%.Cure 13 examples in matched group, effective 20 examples, effective 70 examples, total effectively example 103 example, total effective rate 79.2%, the therapeutic effect of experimental group is obviously better than matched group (P < 0.05).

The improvement situation (improving the front uncomfortable number of cases of number of cases/improvement) of table 2 cardinal symptom

The comparison (unit: `x ± s nmmol/L) of physical and chemical index before and after table 3 liang group patient treatment

Relatively two groups of patients symptomatic improve situation (table 2) and physical and chemical mutagenesis (table 3), result shows, in experimental group, the main clinic symptoms of patient improves, and be obviously better than matched group (P < 0.05), after experimental group and matched group patient treatment, in blood T3, T4, FT3, FT4 all comparatively before obviously reduce, TSH comparatively before to some extent obviously raise, but between two groups of data and there was no significant difference.

Semen Ziziphi Spinosae (parched) tonifying liver in formula of the present invention, mind calming; Herba Cistanches kidney-replenishing, benefiting essence-blood; Fructus Gardeniae pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis; Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination; Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI; Bulbus Fritillariae Thunbergii heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing; Sargassum hard masses softening and resolving, expectorant, diuretic; Concha Ostreae tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving; Fructus Rubi kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination; Semen Sojae Preparatum induces sweat, relieving restlessness, and a surname sends out hot and suffocating; Endoconcha Sepiae astringing to arrest bleeding, relieving leukorrhea by astringents; Rhizoma Alpiniae Officinarum warming stomach for dispelling cold, help digestion pain relieving; Herba Rabdosiae Lophanthoidis clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis; Fructus Citri Sarcodactylis depressed liver-energy dispersing and QI regulating, stomach function regulating reduces phlegm; Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Rhizoma Dioscoreae Bulbiferae removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, multiple medicines merges, altogether long memorial liver and qi, drying dampness to eliminate phlegm, a surname send out hot and suffocating, the effect such as mind tranquilizing and the heart calming, to treatment hyperthyroidism, there is good therapeutic effect.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. hyperthyroid kidney and spleen invigorating side, is characterized in that, is prepared from primarily of following bulk drugs, is weight portion: Semen Ziziphi Spinosae (parched) 10-20, Herba Cistanches 9-15, Fructus Gardeniae 8-15, Semen Cuscutae 8-12, Rhizoma Pinelliae 5-10, Bulbus Fritillariae Thunbergii 8-14, Sargassum 6-9, Concha Ostreae 9-14, Radix Angelicae Sinensis 10-20, Fructus Rubi 10-20, Semen Sojae Preparatum 12-25, Endoconcha Sepiae 9-18, Rhizoma Alpiniae Officinarum 8-16, Radix Tripterygii Wilfordii 3-6, Herba Rabdosiae Lophanthoidis 3-6, Fructus Citri Sarcodactylis 8-12, Rhizoma Dioscoreae 15-20, Pericarpium Citri Reticulatae 15-20, Flos Carthami 8-12, Radix Codonopsis 9-15, Rhizoma Dioscoreae Bulbiferae 6-9.

2. hyperthyroid kidney and spleen invigorating side as claimed in claim 1, it is characterized in that, Semen Ziziphi Spinosae (parched) 12-18, Herba Cistanches 11-13, Fructus Gardeniae 10-13, Semen Cuscutae 9-11, Rhizoma Pinelliae 6-9, Bulbus Fritillariae Thunbergii 10-12, Sargassum 7-8, Concha Ostreae 10-13, Radix Angelicae Sinensis 12-18, Fructus Rubi 12-18, Semen Sojae Preparatum 15-22, Endoconcha Sepiae 10-17, Rhizoma Alpiniae Officinarum 10-14, Radix Tripterygii Wilfordii 4-5, Herba Rabdosiae Lophanthoidis 4-5, Fructus Citri Sarcodactylis 9-11, Rhizoma Dioscoreae 16-19, Pericarpium Citri Reticulatae 16-19, Flos Carthami 9-11, Radix Codonopsis 11-13, Rhizoma Dioscoreae Bulbiferae 7-8 is (preferred, Semen Ziziphi Spinosae (parched) 15, Herba Cistanches 12, Fructus Gardeniae 11.5, Semen Cuscutae 10, Rhizoma Pinelliae 7.5, Bulbus Fritillariae Thunbergii 11, Sargassum 7.5, Concha Ostreae 11.5, Radix Angelicae Sinensis 15, Fructus Rubi 15, Semen Sojae Preparatum 18.5, Endoconcha Sepiae 13.5, Rhizoma Alpiniae Officinarum 12, Radix Tripterygii Wilfordii 4.5, Herba Rabdosiae Lophanthoidis 4.5, Fructus Citri Sarcodactylis 10, Rhizoma Dioscoreae 17.5, Pericarpium Citri Reticulatae 17.5, Flos Carthami 10, Radix Codonopsis 12, Rhizoma Dioscoreae Bulbiferae 7.5).

3. the hyperthyroid kidney and spleen invigorating side as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder, make medicated powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae and Concha Ostreae are scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder, obtained medicamental pulverata;

(4) by other crude drug except Fructus Gardeniae, Herba Cistanches, Endoconcha Sepiae and Concha Ostreae, decontamination, cleans, slightly soak, be placed in pot to steam, take out, after cooling, be placed in baking oven, dry, pulverize and sieve together with step (2) made crude drug, with step (1) (3) made medicated powder and medicamental pulverata, mixing, obtains powder.

4. the preparation method of hyperthyroid kidney and spleen invigorating side as claimed in claim 3 powder, is characterized in that, step (4) is placed in pot and steams 20-40 minute (preferably, steaming 25-35 minute; Be more preferably, steam 30 minutes).

5. the hyperthyroid kidney and spleen invigorating side as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder, make medicated powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae and Concha Ostreae are scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder, obtained medicamental pulverata;

(4) by other crude drug except Fructus Gardeniae, Herba Cistanches, Endoconcha Sepiae and Concha Ostreae, decontamination, cleans, slightly soak, be placed in pot to steam, take out, after cooling, be placed in baking oven, dry, pulverize and sieve together with step (2) made crude drug, with step (1) (3) made medicated powder and medicamental pulverata, mixing, makes mixed powder;

(5) by step (4) made mixed powder, mix with refined honey water, generally make honeyed pill, obtain pill.

6. the preparation method of hyperthyroid kidney and spleen invigorating side as claimed in claim 5 pill, is characterized in that, in step (5) refined honey water, the mass ratio of refined honey and water is that 1:3-1:5(is preferred, and the mass ratio of refined honey and water is 1:4).

7. the hyperthyroid kidney and spleen invigorating side as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, smash into Fructus Gardeniae to pieces powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae is scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder;

(4) remove the Rhizoma Pinelliae after impurity, Bulbus Fritillariae Thunbergii and Concha Ostreae and be placed in pot, add water and do not have crude drug, decoct 20 minutes, add Semen Ziziphi Spinosae (parched), Semen Cuscutae, Sargassum, Radix Angelicae Sinensis, Fructus Rubi, Semen Sojae Preparatum, Rhizoma Alpiniae Officinarum, Radix Tripterygii Wilfordii, Herba Rabdosiae Lophanthoidis, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Flos Carthami, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and step (2) made crude drug, add water and do not have medical material 3cm, soak 30 minutes;

(5) be heated to boiling, then simmer in water that (preferred, simmered in water 35-45 minute in 30-50 minute; Be more preferably, simmer in water 40 minutes), filter, collect filtrate, remaining filtering residue will be filtered and again decoct, filter, merge twice filtrate, step (1) (3) made medicated powder and medicamental pulverata are added in filtrate, stirs, spraying dry, pulverizes, mixes with pharmaceutical excipients, make soft material, granulate, 60-70 DEG C of drying, granulate, obtains granule.

8. the preparation method of hyperthyroid kidney and spleen invigorating side as claimed in claim 7 granule, is characterized in that, the time that step (5) filtering residue decocts again is that (preferred, the time that filtering residue decocts again was 45-55 minute in 40-60 minute; Be more preferably, the time that filtering residue decocts again is 50 minutes).

9. the hyperthyroid kidney and spleen invigorating side as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:

(1) by Fructus Gardeniae decontamination, clean, after steeping in wine stain 3-4 hour, take out and be placed in pot steaming 1 hour again, take out, be exposed to the sun, after drying, Fructus Gardeniae ground into powder;

(2) by Herba Cistanches decontamination, clean, run through, shave, be placed in pot mature vinegar uniform spraying, slightly vexed, use slow fire fried dry, take out, dry in the air cool;

(3) Endoconcha Sepiae is scrubbed clean, dry, pound into fritter, fry to time yellow with slow fire, take out, grind into powder;

(4) remove the Rhizoma Pinelliae after impurity, Bulbus Fritillariae Thunbergii and Concha Ostreae and be placed in pot, add water and do not have crude drug, decoct 20 minutes, add Semen Ziziphi Spinosae (parched), Semen Cuscutae, Sargassum, Radix Angelicae Sinensis, Fructus Rubi, Semen Sojae Preparatum, Rhizoma Alpiniae Officinarum, Radix Tripterygii Wilfordii, Herba Rabdosiae Lophanthoidis, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Flos Carthami, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and step (2) made crude drug, add water and do not have medical material 3cm, soak 30 minutes;

(5) be heated to boiling, then simmer in water, filter, step (1) (3) made medicated powder and medicamental pulverata are added wherein, stirs, obtain decoction.

10. the preparation method of hyperthyroid kidney and spleen invigorating side as claimed in claim 9 decoction, is characterized in that, step (5) simmers in water again, and within 30-50 minute, (preferred, simmer in water 35-45 minute; Be more preferably, simmer in water 40 minutes).