CN104587325A - Preparation method for medicament for treating infantile anorexia - Google Patents
Preparation method for medicament for treating infantile anorexia Download PDFInfo
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- CN104587325A CN104587325A CN201510088929.9A CN201510088929A CN104587325A CN 104587325 A CN104587325 A CN 104587325A CN 201510088929 A CN201510088929 A CN 201510088929A CN 104587325 A CN104587325 A CN 104587325A
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Abstract
The invention relates to a preparation method for a medicament for treating infantile anorexia. The method comprises the following steps: (1), weighting 100 grams of stephania sinica diels, 50 grams of rhizoma corydalis, 100 grams of medicated leaven, 80 grams of neocheiropteris palmatopedata, 50 grams of scirpus fluviatilis, 120 grams of cydonia oblonga, 100 grams of Huangchagen, 50 grams of endothelium corneum gigeriae galli, 100 grams of papayas, 80 grams of tangerine peel, 50 grams of hops, 100 grams of radish seeds, 80 grams of small centipeda herbs, 120 grams of pyropolyporus fomentarium teng, 100 grams of thunbergia fragrans and 90 grams of licorice, adding 6,000 milliliters of water, performing heating refluxing for 3 hours in a flask with a condenser pipe, and performing filtration to obtain filtrate 1 and filter residues 1; (2), adding 2,000 milliliters of water into the filter residues 1, performing heating for 1 hour in the flask with the condenser pipe, and performing filtration to obtain filtrate 2 and filter residues 2; (3), mixing the filtrate 1 and the filtrate 2, performing distillation drying and crushing, adding 200 grams of lanolin and 300 grams of vaseline, performing uniform stirring, and uniformly smearing 100 nonwoven sterile gauzes with the mixture to obtain the medicament.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of preparation method for the treatment of the medicament of infantile anorexia.
Background technology
Infantile anorexia is the commonly encountered diseases in modern children, and 1-6 year children's is common, is reduced to cardinal symptom with longer loss of appetite or disappearance, appetite.Due to the change of modern food structure and dietary habit, the impact of social factor, the factor such as pollution, only child's increase of natural environment, the sickness rate of primary disease has the trend day by day increased in recent years.Apositia all has impact to the growth promoter of children's, nutriture, intelligent development, and severe patient can cause malnutrition and multivitamin and trace element deficiency, affects children's upgrowth and development, therefore is subject to the head of a family and medical circles extensively pay attention to.
Chinese and western medicine is substantially identical to infantile anorexia cause of disease understanding, but has his own strong points in treatment.Western medical treatment primary disease meets body to lacking the needs of material with digestive enzymes, vitamin, the supplementary of trace element, but without specificity, lacks taste and self is to the conditioning of the absorption function of nutrient substance.And the traditional Chinese medical science has unique understanding and abundant Couple herbs to primary disease, treat based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs side's medicine, advocate function of spleen and stomach regulating function, to promote intestinal absorption.
Primary disease belongs to the category such as motherland's medical science " evil food ", " getting ill from overeating ", " food stagnation ", " expectorant is stagnant ".Chinese medicine thinks that pediatric diet does not save, improper feeding, and the normal transportation capabilities of impairing the spleen and stomach, cause incoordination between the spleen and stomach, and transporting of being received is lost strong, and therefore insufficiency of the spleen food stagnation is this pathogenetic Etiological pathogenesis.The active drug of infantile anorexia is studied based on Chinese medicine, significant to raising children's health level.
Summary of the invention
The object of this invention is to provide a kind of preparation method for the treatment of the medicament of infantile anorexia.
In order to realize object of the present invention, the invention provides a kind of preparation method for the treatment of the medicament of infantile anorexia, the method comprises: take Radix polygalae arillatae 100 grams, Rhizoma Corydalis 50 grams, Massa Medicata Fermentata 100 grams, Neocheiropteris palmatopedata(Bak.) Christ 80 grams, Rhizoma Sparganii 50 grams, Fructus cydoniae oblongae 120 grams, yellow tea root 100 grams, Endothelium Corneum Gigeriae Galli 50 grams, Fructus Caricae 100 grams, Pericarpium Citri Reticulatae 80 grams, Flos lupuli (Flos Humuli Lupuli) 50 grams, Semen Raphani 100 grams, Herba Centipedae 80 grams, Fomes Fomentarius 120 grams, Thunbergia fragrans Roxb. 100 grams and 90 grams, Radix Glycyrrhizae, add 6000 ml waters, reflux 3 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1, 2) in described filtering residue 1, add 2000 ml waters, heat 1 hour in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2, 3) merge described filtrate 1 and described filtrate 2, evaporate to dryness, pulverize, add lanoline 200 grams and 300 grams, vaseline, stir, uniform application, on 100 pieces of same nonwoven sterile gauzes, to obtain final product.
The present invention also provides the purposes of compositions in the medicine of preparation treatment infantile anorexia, and described compositions is made up of the material of following weight portion: Radix polygalae arillatae 5-15 part, Rhizoma Corydalis 1-10 part, Massa Medicata Fermentata 5-15 part, Neocheiropteris palmatopedata(Bak.) Christ 1-10 part, Rhizoma Sparganii 1-10 Fen, Fructus cydoniae oblongae 5-15 part, yellow tea root 5-15 part, Endothelium Corneum Gigeriae Galli 1-10 part, Fructus Caricae 5-15 part, Pericarpium Citri Reticulatae 1-10 part, Flos lupuli (Flos Humuli Lupuli) 1-10 part, Semen Raphani 5-15 part, Herba Centipedae 1-10 part, Fomes Fomentarius 5-15 part, Thunbergia fragrans Roxb. 5-15 part and Radix Glycyrrhizae 1-10 part.
Preferably, described compositions is made up of the material of following weight portion: Radix polygalae arillatae 10 parts, Rhizoma Corydalis 5 parts, Massa Medicata Fermentata 10 parts, Neocheiropteris palmatopedata(Bak.) Christ 8 parts, Rhizoma Sparganii 5 Fen, Fructus cydoniae oblongae 12 parts, yellow tea root 10 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Caricae 10 parts, Pericarpium Citri Reticulatae 8 parts, Flos lupuli (Flos Humuli Lupuli) 5 parts, Semen Raphani 10 parts, Herba Centipedae 8 parts, Fomes Fomentarius 12 parts, Thunbergia fragrans Roxb. 10 parts and 9 parts, Radix Glycyrrhizae.
More preferably, described medicine can be tablet, dispersible tablet, capsule, patch or decoction.
In the present compositions, Fomes Fomentarius, Thunbergia fragrans Roxb., Neocheiropteris palmatopedata(Bak.) Christ are monarch drug; Radix polygalae arillatae, Massa Medicata Fermentata, Fructus cydoniae oblongae, yellow tea root, Pericarpium Citri Reticulatae are ministerial drug; Rhizoma Corydalis, Rhizoma Sparganii, Endothelium Corneum Gigeriae Galli, Fructus Caricae, Flos lupuli (Flos Humuli Lupuli), Semen Raphani, Herba Centipedae are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
At home, because household economy is improved, market infant foods supply increases, and only child is pampered and spoiled, and great change occurs for pediatric diet custom and Family's environment factors.And children's's " body does not fill ", " the spleen tending to insufficiency usually ", often affect transportation capabilities, causing breast food stagnates and does not change, and stay in gastral cavity abdomen, burnt in retardance, thus easily occur distension and fullness in the abdomen, food stagnation is hot and suffocating, for a long time impairing the spleen and stomach, and fortune mistake of receiving is executed, and becomes apositia.Medicament of the present invention plays whole synthesis effect, plays the merit of nourishing the stomach nourishing YIN, invigorate the spleen and warm the kidney, promote qi circulation digestion promoting altogether, can promote intestinal motility, strengthen the absorption function of small intestinal, improve Immune Function, achieve good clinical effectiveness, be worthy of popularization.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment patch of the present invention
Take Radix polygalae arillatae 100 grams, Rhizoma Corydalis 50 grams, Massa Medicata Fermentata 100 grams, Neocheiropteris palmatopedata(Bak.) Christ 80 grams, Rhizoma Sparganii 50 Ke, Fructus cydoniae oblongae 120 grams, yellow tea root 100 grams, Endothelium Corneum Gigeriae Galli 50 grams, Fructus Caricae 100 grams, Pericarpium Citri Reticulatae 80 grams, Flos lupuli (Flos Humuli Lupuli) 50 grams, Semen Raphani 100 grams, Herba Centipedae 80 grams, Fomes Fomentarius 120 grams, Thunbergia fragrans Roxb. 100 grams and 90 grams, Radix Glycyrrhizae, add 6000 ml waters, reflux 3 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1; 2) in described filtering residue 1, add 2000 ml waters, heat 1 hour in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2; 3) merge described filtrate 1 and described filtrate 2, evaporate to dryness, pulverize, add lanoline 200 grams and 300 grams, vaseline, stir, uniform application, on 100 pieces of same nonwoven sterile gauzes, to obtain final product.
The curative effect of experimental example medicament of the present invention
1 data and method
1.1 physical data
This group children with anorexia is totally 80 examples, is divided into treatment group 40 example and matched group 40 example.Wherein treatment group man 23 example, women 17 example; Age between 2-12 year, 8.7 years old mean age; Average 9.4 ± 2.1 months of the course of disease.Matched group man 22 example, women 18 example; Age between 2-13 year, 8.5 years old mean age; Average 9.6 ± 1.9 months of the course of disease.Two groups of infants, at the equal not statistically significant of the difference of above-mentioned each side (p > 0.05), have comparability.
1.2 observation index
The symptom and sign scalar quantization standard formulating infantile anorexia is as follows:
(1) loss of appetite
Normal 0 point
Light 2 points of appetite slightly subtract, and know hungry few food
In 4 points of loss of appetite more, not hungry inadequate feed
Weigh 6 points of appetite to go down in a large number, often meal feed seldom, not hungry few food
(2) appetite reduces
Normal 0 point
Light 2 points of appetite slightly subtract, compared with normal few about 1/3
In 4 points of appetite reduce, compared with normal few about 1/2
Weigh 6 points of appetite to reduce, compared with normal few about 2/3
(3) suffer from abdominal pain
Without 0 point
Light 1 point of idol has abdominal part hypodynia, spontaneous remission in half an hour
In 2 points stomachache more very, still can stand, persistent period 0.5-1 hour
Weigh 3 points of stomachache to be difficult to stand, the pain of pressing is obvious, still can not alleviate in 2 hours
(4) abdominal distention
Without 0 point
Light 1 point of abdominal distention is slight, alleviates or disappear in half an hour, does not affect study and activity
In 2 points of abdominal distention more very, persistent period 0.5-1 hour, some effects study and movable
Weigh 3 points of abdominal distention more very, still can not alleviate in 2 hours, impact study and activity.
1.3 Therapeutic Method
Treatment group takes the patch of the present invention prepared in embodiment, 1 times/day, is attached on the umbilicus of infant by 1 piece of patch at every turn.Be a course for the treatment of with 7 days, take 2 courses for the treatment of continuously.Matched group takes tuckahoe spleen-strengthening granule (authentication code: the accurate word B20020619 of traditional Chinese medicines, Hangzhou Guoguang Pharmaceutical Co., Ltd. produces), less than 5 years old infant 1 bag (10 grams)/time, 2 times/day, more than 5 years old infants 1 bag (10 grams)/time, 3 times/day.Be a course for the treatment of with 7 days, take 2 courses for the treatment of continuously.
1.4 criterion of therapeutical effect
The criterion of therapeutical effect of infantile anorexia is formulated as follows.According to before treatment, rear twice scoring score value calculates therapeutic index (N) and effective percentage with treatment.
Cure: symptom, sign disappear or substantially disappear, and appetite appetite returns to normal level, N >=95%;
Effective: symptom, sign are obviously improved, and appetite is obviously recovered, appetite returns to 3/4, N=70%-95% of normal level;
Effective: symptom, sign take a turn for the better to some extent, and appetite is improved, and appetite is recovered to some extent, but do not reach 3/4, N=30%-70% of normal amount;
Invalid: symptom, sign are not improved or increase the weight of, N < 30%.
Wherein,
Score value × 100% before therapeutic index (N)=(before treatment the rear score value of score value-treatment)/treatment
Effective percentage=(cure+effective+effectively) number of cases/total number of cases × 100%
1.5 statistical method
SPSS13.0 statistical software is adopted to carry out data analysis.Measurement data with
represent, adopt t inspection; Enumeration data adopts x
2inspection.With p < 0.05 for difference has statistical significance.
2 results
2.1 symptoms, sign are marked
Symptom before and after the treatment of two groups of infants, the change of sign scoring score value relatively in table 1.As can be seen from Table 1, two groups of infants score value not statistically significant before the treatment (p > 0.05), and after treating 14 days, two groups of infant symptoms, signs all improve, its score value declines all to some extent, difference has statistical significance (p<0.05), and treatment group comparatively matched group decline more obvious, group difference has statistical significance (p<0.05).
The comparison of table 1 liang group infant symptom, the change of sign scoring score value
Note: compare with before treatment, * p<0.05; Compare with matched group, * * p<0.05
2.2 clinical efficacy
The clinical efficacy of two groups of infants relatively in table 2.Table 2 shows, and the difference of two groups of infant clinical efficacies has statistical significance (p<0.05).This shows that treatment group symptom takes a turn for the better and is better than matched group, and the clinical efficacy of medicament of the present invention is better than tuckahoe spleen-strengthening granule.
Table 2 Clinical efficacy comparison
Note: compare with matched group, * p<0.05.
Claims (4)
1. treat the preparation method of the medicament of infantile anorexia for one kind, the method can comprise: take Radix polygalae arillatae 100 grams, Rhizoma Corydalis 50 grams, Massa Medicata Fermentata 100 grams, Neocheiropteris palmatopedata(Bak.) Christ 80 grams, Rhizoma Sparganii 50 Ke, Fructus cydoniae oblongae 120 grams, yellow tea root 100 grams, Endothelium Corneum Gigeriae Galli 50 grams, Fructus Caricae 100 grams, Pericarpium Citri Reticulatae 80 grams, Flos lupuli (Flos Humuli Lupuli) 50 grams, Semen Raphani 100 grams, Herba Centipedae 80 grams, Fomes Fomentarius 120 grams, Thunbergia fragrans Roxb. 100 grams and 90 grams, Radix Glycyrrhizae, add 6000 ml waters, reflux 3 hours in the flask that condensing tube is housed, then filter, obtain filtrate 1 and filtering residue 1; 2) in described filtering residue 1, add 2000 ml waters, heat 1 hour in the flask that condensing tube is housed, filter, obtain filtrate 2 and filtering residue 2; 3) merge described filtrate 1 and described filtrate 2, evaporate to dryness, pulverize, add lanoline 200 grams and 300 grams, vaseline, stir, uniform application, on 100 pieces of same nonwoven sterile gauzes, to obtain final product.
2. the purposes of compositions in the medicine of preparation treatment infantile anorexia, is characterized in that described compositions is made up of the material of following weight portion: Radix polygalae arillatae 5-15 part, Rhizoma Corydalis 1-10 part, Massa Medicata Fermentata 5-15 part, Neocheiropteris palmatopedata(Bak.) Christ 1-10 part, Rhizoma Sparganii 1-10 Fen, Fructus cydoniae oblongae 5-15 part, yellow tea root 5-15 part, Endothelium Corneum Gigeriae Galli 1-10 part, Fructus Caricae 5-15 part, Pericarpium Citri Reticulatae 1-10 part, Flos lupuli (Flos Humuli Lupuli) 1-10 part, Semen Raphani 5-15 part, Herba Centipedae 1-10 part, Fomes Fomentarius 5-15 part, Thunbergia fragrans Roxb. 5-15 part and Radix Glycyrrhizae 1-10 part.
3. purposes according to claim 2, wherein said compositions is made up of the material of following weight portion: Radix polygalae arillatae 10 parts, Rhizoma Corydalis 5 parts, Massa Medicata Fermentata 10 parts, Neocheiropteris palmatopedata(Bak.) Christ 8 parts, Rhizoma Sparganii 5 Fen, Fructus cydoniae oblongae 12 parts, yellow tea root 10 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Caricae 10 parts, Pericarpium Citri Reticulatae 8 parts, Flos lupuli (Flos Humuli Lupuli) 5 parts, Semen Raphani 10 parts, Herba Centipedae 8 parts, Fomes Fomentarius 12 parts, Thunbergia fragrans Roxb. 10 parts and 9 parts, Radix Glycyrrhizae.
4. purposes according to claim 3, wherein said medicine can be tablet, dispersible tablet, capsule, patch or decoction.
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Citations (3)
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| CN1686221A (en) * | 2005-03-31 | 2005-10-26 | 周鑫 | Umbilicus sticking powder for treating child aversion to food |
| CN102657799A (en) * | 2012-05-23 | 2012-09-12 | 天津药业集团新郑股份有限公司 | External application for treatment of infantile anorexia and preparation method thereof |
| CN103416460A (en) * | 2012-05-20 | 2013-12-04 | 陈冠卿 | Healthy food capable of preventing and curing anorexia of children |
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- 2015-02-26 CN CN201510088929.9A patent/CN104587325A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686221A (en) * | 2005-03-31 | 2005-10-26 | 周鑫 | Umbilicus sticking powder for treating child aversion to food |
| CN103416460A (en) * | 2012-05-20 | 2013-12-04 | 陈冠卿 | Healthy food capable of preventing and curing anorexia of children |
| CN102657799A (en) * | 2012-05-23 | 2012-09-12 | 天津药业集团新郑股份有限公司 | External application for treatment of infantile anorexia and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 吉训超等: "中药敷脐法治疗小儿厌食症65例疗效观察", 《新中医》 * |
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