CN104548392A - Transcranial ultrasonic stimulation device and stimulation method - Google Patents
Transcranial ultrasonic stimulation device and stimulation method Download PDFInfo
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- CN104548392A CN104548392A CN201510021745.0A CN201510021745A CN104548392A CN 104548392 A CN104548392 A CN 104548392A CN 201510021745 A CN201510021745 A CN 201510021745A CN 104548392 A CN104548392 A CN 104548392A
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Abstract
The invention provides a transcranial ultrasonic stimulation device and a stimulation method for carrying out nervous tissue orientation and neuromodulation through transcranial ultrasonic stimulation. The transcranial ultrasonic stimulation device comprises an upper computer unit, an ultrasonic pulse transmission unit, an ultrasonic transduction unit and a power circuit. The transcranial ultrasonic stimulation device adopts the integrated circuit mode and further comprises an echo amplification circuit. The focal distance of the ultrasonic transduction unit is 30 mm. The ultrasonic pulse transmission voltage is adjusted by adjusting the power supply voltage, and therefore the transcranial ultrasonic stimulation device is small in size and high in spatial orientation resolution ratio and can achieve system self-inspection. Meanwhile, because the ultrasonic intensity can be adjusted, a low ultrasonic intensity can be selected for carrying out nervous tissue orientation and neuromodulation, a high ultrasonic intensity can be selected for carrying out tissue damage, and the positional information of the stimulation part can be verified.
Description
Technical field
The invention belongs to nerve stimulation technical field, being specifically related to a kind of TCD,transcranial Doppler stimulating apparatus and a kind of TCD,transcranial Doppler stimulates method for neuromodulation.
Background technology
Traditional stimulating through cranial nerve has three kinds of methods usually: external electrode method, inputs cerebral tissue through skin and osseous tissue electrode by pulse current; Microelectrode method, is mainly used in the neuromodulation of deep-brain; Neural stem cell method, relative to first two method, the time of appearance is more late, and the method refers to logical high frequency electric in coil, produces alternating electromagnetic field, forms electromagnetic wave and enters nervous tissue to play Neuromodulation.All there is certain defect in three kinds of traditional methods.External electrode method can only stimulate the nervous tissue of shallow table, and microelectrode method needs electrode to be inserted in brain, be that one has damage method, and the focus of Neural stem cell method is Centimeter Level, is difficult to accurate location.
Utilizing TCD,transcranial Doppler ripple to modulate brain neuroblastoma, is the ultrasonic important application in non-invasive medical field, by the focusing ultrasonic wave of external transmitting, makes focus act on nervous tissue, can realize the efficient modulation to brain neuroblastoma.But TCD,transcranial Doppler of the prior art stimulates generating means to be mostly to be spliced by multiple stage equipment, not only volume is large, uses inconvenience, and does not possess stimulation location and ultrasound intensity self-checking function.
Summary of the invention
The present invention carries out for solving the problem, by providing a kind of TCD,transcranial Doppler stimulating apparatus of detected ultrasonic echo of integrated form, not only easy to use, and possesses and stimulate location and ultrasound intensity self-checking function.
Present invention employs following technical scheme:
TCD,transcranial Doppler stimulating apparatus provided by the invention, for generation of the ultrasonic pulse stimulated intracranial nerve, has such feature, comprising: host computer unit, for transmitting manipulation command parameter; Ultrasound pulse transmission unit, be connected with host computer unit, comprise the programmable pulse generating assembly and ultrasound pulse transmission circuit that are linked in sequence, programmable pulse generating assembly for receiving the manipulation command parameter of host computer unit, and drives ultrasound pulse transmission circuit to send high electric field pulse; Ultrasonic transduction unit, is connected with ultrasound pulse transmission unit, for high electric field pulse signal is converted to ultrasonic pulse, and power circuit, for powering to ultrasound pulse transmission unit, wherein, the pulse voltage of ultrasound pulse transmission circuit is adjustable.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have such feature, also comprise: echo reception amplifying circuit, for amplifying ultrasound echo signal.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have such feature: ultrasound pulse transmission unit also comprises buffer circuit, and the noise voltage by a small margin for blocking ultrasound pulse transmission unit enters ultrasonic echo and receives amplifying circuit.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have such feature, also comprise: oscillograph, for showing the ultrasound echo signal that echo reception amplifying circuit exports.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have such feature: ultrasonic transduction unit is focused transducer.
TCD,transcranial Doppler stimulating apparatus provided by the invention, such feature can also be had: host computer unit is the various computers that can run Graphic Operating System such as desk computer, notebook or tablet PC, and the manipulation command parameter of its interface configurations comprises ultrasonic mid frequency, pulse duration, pulse recurrence frequency and pulse duration.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have such feature: ultrasound pulse transmission voltage is adjustable.
TCD,transcranial Doppler stimulating apparatus provided by the invention, can also have such feature: the gain of echo reception amplifying circuit is adjustable.
Further, the invention provides a kind of method that TCD,transcranial Doppler stimulating apparatus carries out nervous tissue location and neuromodulation, it is characterized in that, comprise the following steps:
Step one, the control inerface of host computer unit selects " station-keeping mode ";
Step 2, brain position finder is determined the position needing to carry out the nervous tissue stimulated, and places needle point reverberation at this place, and ultrasonic transduction unit is aimed at needle point reverberation;
Step 3, impulse ejection circuit repeats the high pressure pulse signal of telecommunication sent, and sends ultrasonic pulse through buffer circuit rear drive ultrasonic transduction unit;
Step 4, the position of adjustment ultrasonic transduction unit and angle, when echo-signal is the strongest, illustrate that the position of needle point reverberation is exactly the focal position of ultrasonic transduction unit;
Step 5, keeps ultrasonic transduction cell position constant, is removed by needle point reverberation, body need be stimulated to be fixed on brain position finder by brain map requirement from brain position finder;
Step 6, the control inerface of upper computer module selects " stimulus modelity ";
Step 7, selects suitable pulse parameter, pulse voltage and ultrasonic transduction unit, produces ultrasound stimulation impulse stimulation nervous tissue, modulates nervous tissue.
Further, present invention also offers a kind of method that TCD,transcranial Doppler stimulating apparatus carries out nervous tissue's damage, for verifying the positional information of the site of action of ultrasound stimulation in zoopery, it is characterized in that, comprising the following steps:
Step one, the control inerface of host computer unit selects " station-keeping mode ";
Step 2, brain position finder is determined the position needing to carry out the nervous tissue stimulated, and places needle point reverberation at this place, and ultrasonic transduction unit is aimed at needle point reverberation;
Step 3, impulse ejection circuit repeats the high pressure pulse signal of telecommunication sent, and sends ultrasonic pulse through buffer circuit rear drive ultrasonic transduction unit;
Step 4, the position of adjustment ultrasonic transduction unit and angle, when echo-signal is the strongest, illustrate that the position of needle point reverberation is exactly the focal position of ultrasonic transduction unit;
Step 5, keeps ultrasonic transduction cell position constant, is removed by needle point reverberation, body need be stimulated to be fixed on brain position finder by brain map requirement from brain position finder;
Step 6, the control inerface of host computer unit selects " Wear mode ", and under " Wear mode ", improve pulse voltage, impulse ejection circuit sends continuous impulse, to damage the nervous tissue at focus place simultaneously.
Invention effect and effect
The invention provides a kind of TCD,transcranial Doppler stimulating apparatus and a kind of TCD,transcranial Doppler and stimulate the method for carrying out nervous tissue location and neuromodulation, TCD,transcranial Doppler stimulating apparatus comprises the host computer unit for command parameters, the ultrasound pulse transmission unit be connected with host computer unit, comprises the programmable pulse generating assembly, ultrasound pulse transmission circuit and the buffer circuit that are linked in sequence, ultrasonic transduction unit, be connected with ultrasound pulse transmission unit, for high electric field pulse is converted to ultrasonic pulse, and power circuit, for powering to ultrasound pulse transmission unit, because TCD,transcranial Doppler stimulating apparatus provided by the invention adopts ic-type, also comprise echo amplifying circuit, the focal length of ultrasonic transduction unit is 30mm, realized the adjustment of ultrasound pulse transmission voltage by the adjustment of power source supplying voltage simultaneously, make TCD,transcranial Doppler stimulating apparatus volume provided by the invention little, spatial positioning resolution is high, and feasible system self-inspection, whether judgment device situation offsets, simultaneously because ultrasound intensity is adjustable, low ultrasound intensity can be selected to carry out tissue positioned and neuromodulation, high ultrasound intensity is selected to carry out tissue damage, with the positional information of checking at zoopery moderate stimulation site of action.
Accompanying drawing explanation
Fig. 1 is the structural representation of TCD,transcranial Doppler stimulating apparatus of the present invention;
Fig. 2 utilizes TCD,transcranial Doppler stimulating apparatus of the present invention to carry out the process flow diagram flow chart of neuromodulation.
Detailed description of the invention
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is described.
Fig. 1 is the structural representation of the TCD,transcranial Doppler stimulating apparatus in the present embodiment.
As shown in Figure 1, host computer unit 1, ultrasound pulse transmission unit 2, ultrasonic transduction unit 3, pressure limiting circuit 4, echo reception amplifying circuit 5, oscillograph 6, power circuit 7 and synchronizing indicator 8 is comprised through cranial nerve stimulating apparatus 100.Wherein, ultrasound pulse transmission unit 2, pressure limiting circuit 4, echo reception amplifying circuit 5 and power circuit 7 are positioned at cabinet, and miscellaneous part is positioned at outside cabinet.Ultrasound pulse transmission unit 2 comprises the programmable pulse generating assembly 21, ultrasound pulse transmission circuit 22 and the buffer circuit 23 that are linked in sequence.
Host computer unit 1 passes down the parameter of control signal and ultrasonic pulse to programmable pulse generating assembly 21 by serial ports, after programmable pulse generating assembly 21 receives parameter, the parameter of control signal and ultrasonic pulse is converted into switching pulse EP+ and EP-under special parameter, switching pulse drives ultrasound pulse transmission circuit 22 to send high electric field pulse, and high electric field pulse is input to ultrasonic transduction unit 3 after buffer circuit 23.Then, high electric field pulse is converted to ultrasonic pulse for carrying out neuromodulation by ultrasonic transduction unit 3.
Pressure limiting circuit 4 and ultrasonic echo receive amplifying circuit 5 and are connected, ultrasound pulse transmission unit is got back to for avoiding ultrasound echo signal, echo reception amplifying circuit 5 adjustable gain, for amplifying the ultrasound echo signal of intracranial neural reflex, ultrasound echo signal when stimulating location through amplifying is exported by echo and shows with certain forms in oscillograph 6, convenient operation person direct vision echo.
Power circuit 7 is for powering to ultrasound pulse transmission unit 2, the voltage of power circuit is adjustable simultaneously, for regulating the pulse voltage of ultrasound pulse transmission circuit 22, and then regulates ultrasound intensity, the low sound intensity is used for nervous tissue location and nerve stimulation, and the high sound intensity is for organizing damage.
Synchronizing indicator 8 is connected with programmable pulse generating assembly 21, for the working condition of Real-Time Monitoring programmable pulse generating assembly 21.
In the present embodiment, host computer unit is the various computers that can run Graphic Operating System such as desk computer, notebook or tablet PC, the parameter information of its interface configurations and scope thereof are: ultrasonic mid frequency (Ft) is 100KHZ-2MHZ, pulse duration (PD) is 0.1ms-10ms, pulse recurrence frequency (PRF) is 10HZ-2KHZ, and the pulse duration (SD) is 0.5min-60min.
In the present embodiment, programmable pulse emitting module FPGA realizes, and FPGA launches the switching pulse EP+ under special parameter after receiving data, EP-is to ultrasound pulse transmission circuit.
In the present embodiment, the scope that ultrasonic echo receives amplifying circuit adjustable gain is :-10dB-20dB, and the available ultrasonic pulse voltage range of power circuit is at ± 20V-± 80V.
Ultrasonic transduction unit in the present embodiment is focused transducer, and the focal length of this ultrasonic transducer is 30mm, according to actual needs, can select the focused transducer of three kinds of mid frequencyes difference 500KHZ, 1MHZ and 1.25MHZ.
Further, the present embodiment additionally provide a kind of utilize the TCD,transcranial Doppler stimulating apparatus in the present embodiment carry out nervous tissue location, neuromodulation and tissue damage method.
Fig. 2 is the method flow diagram utilizing the TCD,transcranial Doppler stimulating apparatus in the present embodiment to carry out nervous tissue location and neuromodulation.
As shown in Figure 2, TCD,transcranial Doppler stimulates the step of carrying out nervous tissue location and neuromodulation as follows:
Step one, the control inerface of host computer unit selects " station-keeping mode ";
Step 2, brain position finder is determined the position needing to carry out the nervous tissue stimulated, and places needle point reverberation at this place;
Step 3, impulse ejection circuit 22 repeats to send the two-way pulse signal of telecommunication, and the two-way pulse signal of telecommunication sends ultrasonic pulse through buffer circuit 23 rear drive focused transducer 3;
Step 4, by the alignment probe needle point reverberation of focused transducer 3 and by oscillograph 6 observed echo signal;
Step 5, the position of adjustment focused transducer 3 and angle, find echo maximum, now the position at needle point reverberation place is the focal position of focused transducer 3;
Step 6, keeps the invariant position of focused transducer 3, is removed by needle point reverberation, body need be stimulated to be fixed on brain position finder by brain map requirement from brain position finder;
Step 7, the control inerface of host computer PC selects " stimulus modelity ";
Step 8, select suitable pulse parameter, pulse voltage according to practical situation, focused transducer 3 produces ultrasound stimulation signal stimulus nervous tissue, modulates nervous tissue.
Under being applied to zooperal situation, after experiment terminates, if need the positional information verifying stimulation position, Wear mode can be used.In this mode, impulse ejection circuit 22 sends continuous wave, also needs the pulse voltage of impulse ejection circuit 22 to be increased to high voltage simultaneously, after long enough, can damage the nervous tissue at focus place.The nervous tissue of diverse location is damaged, needs to be determined by experiment pulse voltage, ultrasonic wavelength and persistent period.
After experiment terminates, put to death and dissect animal, observing the change of its cerebral tissue, determine the precise location stimulated.
Simultaneously, TCD,transcranial Doppler stimulating apparatus in the present embodiment can also carry out System self-test, particular content is: after TCD,transcranial Doppler stimulating apparatus 100 is assembled, by pulse-echo method, under the pulse voltage and echo gain amplifier of setting, measure the echo strength of focus place flat target under vertical incidence condition and to go forward side by side line item; In follow-up use procedure, can measure under the same conditions echo strength and and protocol contrast, get final product determining apparatus state whether there occurs skew.
Embodiment effect and effect
Present embodiments provide a kind of TCD,transcranial Doppler stimulating apparatus and a kind of TCD,transcranial Doppler and stimulate the method for carrying out nervous tissue location and neuromodulation, TCD,transcranial Doppler stimulating apparatus comprises the host computer unit for command parameters, the ultrasound pulse transmission unit be connected with host computer unit, comprises the programmable pulse generating assembly, ultrasound pulse transmission circuit and the buffer circuit that are linked in sequence, ultrasonic transduction unit, be connected with ultrasound pulse transmission unit, for high electric field pulse is converted to ultrasonic pulse, and power circuit, for powering to ultrasound pulse transmission unit, the TCD,transcranial Doppler stimulating apparatus provided due to the present embodiment adopts ic-type, also comprise echo amplifying circuit, the focal length of ultrasonic transduction unit is 30mm, realized the adjustment of ultrasound pulse transmission voltage by the adjustment of power source supplying voltage simultaneously, the TCD,transcranial Doppler stimulating apparatus volume that the present embodiment is provided is little, spatial positioning resolution is high, and feasible system self-inspection, whether judgment device situation offsets, simultaneously because ultrasound intensity is adjustable, low ultrasound intensity can be selected to carry out tissue positioned and neuromodulation, high ultrasound intensity is selected to carry out tissue damage, to verify the positional information at stimulation position.
The invention is not restricted to the scope of detailed description of the invention; to those skilled in the art; as long as various change to limit and in the spirit and scope of the present invention determined in described claim; these changes are apparent, and all innovation and creation utilizing the present invention to conceive are all at the row of protection.
Claims (10)
1. a TCD,transcranial Doppler stimulating apparatus, for generation of the ultrasonic pulse stimulated intracranial nerve, is characterized in that, comprising:
Host computer unit, for transmission of control signals and ultrasonic pulse parameter;
Ultrasound pulse transmission unit, be connected with described host computer unit, comprise the programmable pulse generating assembly and ultrasound pulse transmission circuit that are linked in sequence, described programmable pulse generating assembly is for receiving the manipulation command parameter of described host computer unit, and drive described ultrasound pulse transmission circuit to send high electric field pulse
Ultrasonic transduction unit, is connected with described ultrasound pulse transmission unit, for described high electric field pulse is converted to ultrasonic pulse, and
Power circuit, for powering to described ultrasound pulse transmission unit,
Wherein, the pulse voltage of described ultrasound pulse transmission circuit is adjustable.
2. TCD,transcranial Doppler stimulating apparatus according to claim 1, is characterized in that, also comprise:
Echo reception amplifying circuit, for amplifying the ultrasound echo signal through described intracranial neural reflex.
3. TCD,transcranial Doppler stimulating apparatus according to claim 2, is characterized in that:
Wherein, described ultrasound pulse transmission unit also comprises buffer circuit, and described buffer circuit enters described ultrasonic echo for the noise voltage by a small margin blocking described ultrasound pulse transmission unit and receives amplifying circuit.
4. TCD,transcranial Doppler stimulating apparatus according to claim 2, is characterized in that, also comprise:
Oscillograph, for showing the ultrasound echo signal that described echo reception amplifying circuit exports.
5. TCD,transcranial Doppler stimulating apparatus according to claim 1, is characterized in that:
Wherein, described ultrasonic transduction unit is focused transducer.
6. TCD,transcranial Doppler stimulating apparatus according to claim 1, is characterized in that:
Wherein, described host computer unit is the computer that can run Graphic Operating System, and the described ultrasonic pulse parameter that the interface of described computer configures comprises ultrasonic mid frequency, pulse duration, pulse recurrence frequency and pulse duration.
7. TCD,transcranial Doppler stimulating apparatus according to claim 1, is characterized in that:
Wherein, the voltage of described ultrasound pulse transmission circuit is adjustable.
8. TCD,transcranial Doppler stimulating apparatus according to claim 2, is characterized in that:
Wherein, described echo reception amplifying circuit adjustable gain.
9. TCD,transcranial Doppler stimulates a method of carrying out nervous tissue location and neuromodulation, it is characterized in that, comprises the following steps:
Step one, the control inerface of host computer unit selects " station-keeping mode ";
Step 2, brain position finder is determined the position needing to carry out the nervous tissue stimulated, and places needle point reverberation at this place, and ultrasonic transduction unit is aimed at described needle point reverberation;
Step 3, the high pressure pulse signal of telecommunication that impulse ejection circuit repeats to send drives described ultrasonic transduction unit to send ultrasonic pulse;
Step 4, adjusts position and the angle of described ultrasonic transduction unit, and when in oscillograph, echo-signal is the strongest, the position of described needle point reverberation is the focal position of described ultrasonic transduction unit;
Step 5, keeps described ultrasonic transduction cell position constant, is removed by described needle point reverberation from brain position finder, and body need be stimulated to be fixed on described brain position finder by the requirement of brain map;
Step 6, the control inerface of described host computer unit selects " stimulus modelity ";
Step 7, selects suitable pulse parameter, pulse voltage and ultrasonic transduction unit, produces ultrasound stimulation signal stimulus nervous tissue, modulates described nervous tissue.
10. TCD,transcranial Doppler stimulates a method of carrying out nervous tissue's damage, for verifying the positional information of the site of action of described ultrasound stimulation in zoopery, it is characterized in that, comprising the following steps:
Step one, the control inerface of host computer unit selects " station-keeping mode ";
Step 2, brain position finder is determined the position needing to carry out the nervous tissue stimulated, and places needle point reverberation at this place, and ultrasonic transduction unit is aimed at described needle point reverberation;
Step 3, the high pressure pulse signal of telecommunication that impulse ejection circuit repeats to send drives described ultrasonic transduction unit to send ultrasonic pulse;
Step 4, adjusts position and the angle of described ultrasonic transduction unit, when echo-signal is the strongest, illustrates that the position of needle point reverberation is exactly the focal position of ultrasonic transduction unit;
Step 5, keeps described ultrasonic transduction cell position constant, is removed by described needle point reverberation from described brain position finder, and body need be stimulated to be fixed on described brain position finder by brain map requirement;
Step 6, the control inerface of described host computer unit selects " Wear mode ", under described " Wear mode ", improves described pulse voltage, and described impulse ejection circuit sends continuous impulse, to damage the nervous tissue at described focus place simultaneously.
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| CN112043379A (en) * | 2020-08-06 | 2020-12-08 | 韶关东阳光自动化设备有限公司 | Accurate focusing method and system of phased array transducer |
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