CN104548113B - A kind of production technology of film coating agent - Google Patents
A kind of production technology of film coating agent Download PDFInfo
- Publication number
- CN104548113B CN104548113B CN201410763878.0A CN201410763878A CN104548113B CN 104548113 B CN104548113 B CN 104548113B CN 201410763878 A CN201410763878 A CN 201410763878A CN 104548113 B CN104548113 B CN 104548113B
- Authority
- CN
- China
- Prior art keywords
- coating agent
- production technology
- rotating speed
- plasticizer
- filmogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Cosmetics (AREA)
- Paints Or Removers (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
The present invention relates to a kind of production technology of film coating agent, the production method is mainly crushed using high pressure draught to material.The problem of heavy metal and raw material particle size in film coating agent producing process be present in prior art.The method good crushing effect of the present invention, product cut size are thin and uniform；High velocity air can avoid material heated denaturalization；Coating agent finished product heavy metal analysis meets the control requirement of food, health products trade；Production efficiency is higher.
Description
Technical field：
The present invention relates to a kind of preparation method of medicament clothing sheet material, more particularly to a kind of production technology of film coating agent
Background technology：
Film coating is a kind of new art for coating, is that polymer solution or suspension are ejected into piece wicking surface to be formed
A few micrometers of one layer of thick more stable plastic thin film layers, make up to certain Expected Results, this technical process is referred to as thin
Film coating.When Swertia Tablet operates in seed-coating machine, the superfine small drop of Coating Solution or suspension is ejected into the outer of label
Table, when these drops reach label, by contacting, hitting, sprawling, coalescing, dry, one layer of clothing is formed on the surface of label
Film.
Film coating procedure can be divided into aqueous coatings technique and organic solvent art for coating according to the difference of solvent.Film
Being coated purpose is mainly:Improve outward appearance and be easy to identify, cover bad smell, facilitate patients, mitigate gastrointestinal reaction, control
Insoluble drug release, change drug release patterns, protection against the tide, lucifuge, completely cut off air to increase the stability of medicine.
Film coating process is critical that with excellent film coating agent.Film coating agent generally by high polymer material,
Plasticizer, colouring agent etc. form, have strict compatibility in kind and quantity, with ensure medicine core surface energy formed one layer or
Several layers of clothing film continuous, fine and close, lasting and with specific function.So superior in quality film coating agent should meet operation side
Just, quick dissolving, be suspended uniformly, atomization is good, film forming is rapid, unilateral attractive in appearance, colour stable and moisture resistance height etc. require.
The existing frequently-used coating agent mode of production is generally divided into ball-milling method, comminuting method etc..Ball-milling method is relatively simple：In ball milling
In tank operation process, porcelain ball or metal ball phase mutual friction are mixed and disperseed to material, and this mode by equipment rotating speed due to being limited
System, ball operating linear velocity is not high, the limited strength of application, need to obtain the scattered of coloring agent particle by extending milling time, when
Between be up to 3-5 hours, low production efficiency, and due to the scattered not up to thinner state of colouring agent, colour stable between product batches
Property can not ensure.
Rule is crushed to hit material by weight or weight, mechanical force is enough to overcome the cohesiveness between colouring agent,
Reach required fineness, but surface area increases after colouring agent refinement, surface free energy rise, because surface energy is made after cancellation external force
With, still have the generation of reunion situation, cause product colour is uneven, in operation phenomena such as sedimentation, stifled rifle；Moreover, high-speed impact
Part high polymer material molecular chain rupture or denaturation can be caused with overheat, influences the filming performance of product.
In my company (Tianjin Bokelin Medicine Packaging Technology Co., Ltd.) patent (Patent No. authorized in 2011
ZL200910069076.9 in), although overcoming some shortcomings in ball-milling method and comminuting method, many technological problemses are solved,
But when coating agent is applied in food, health products coating, it is possible to cause indivedual batch heavy metals exceeding standards；This is due to divide at a high speed
During dissipating, collision and friction are produced between material and equipment blade, bucket wall, very small amount metal ingredient is likely to result in and comes off,
It is blended in material.Because amount is larger, compared with medicine, food, health products heavy metal require tightened up：For example curing
In medicine product, heavy metal limit should be generally less than 10-20ppm, and the limitation of lead is no more than 0.5ppm in food and health products, arsenic
Limitation be no more than 0.3ppm, control is strict, only has very small amount metal ingredient also to have exceeded risk even if in product.And
And with the use of new material, when the larger filmogen of indivedual particle diameters is applied to coating agent, the slow-speed of revolution can not provide enough
Energy is crushed, and because particle diameter is different between different material, is likely to result in and is mixed uneven situation, influence color and production
Moral character energy.
In order to solve asking for prior art heavy metal present in film coating agent producing process and raw material particle size
Topic, we have developed new coating agent producing process, its cardinal principle is that material is crushed using high pressure draught.
The content of the invention
The present invention provides a kind of film coating agent producing process, and the technique solves film coating present in prior art
The problem of content of beary metal is more in agent and particle diameter is uneven.
The present invention is achieved by the following technical solutions：
A kind of production technology of film coating agent, the production method comprise the following steps：
Step 1, filmogen is put into the mixer for having blade, start mixer, blade rotating speed is controlled in 200-
1000r/min, plasticizer is slowly added into, operates 6-15min；
Step 2, colouring agent is added, the control of blade rotating speed is in 200-1000r/min, operating 10-20min；Obtain three kinds into
The mixture divided；
Step 3, mixture are crushed with airslide disintegrating mill, and the Stress control of compressed air is in 0.7-1.0MPa, size controlling
In 1-20 μ ms, produce.
Film coating agent in the above method, the composition of each component are as follows：
The parts by weight of filmogen 30~85；
The parts by weight of plasticizer 6~22；
The parts by weight of colouring agent 9~50.
Preferably, the composition of each component is as follows：
The parts by weight of filmogen 44~82；
The parts by weight of plasticizer 10~18；
The parts by weight of colouring agent 17~38.
Described film forming agent is in hydroxypropyl methyl cellulose, methylcellulose, hydroxypropyl cellulose, polyacrylic resin
It is one or more of.
Described plasticizer is one or more of in glycerine, castor oil, triethyl citrate.
Described colouring agent is sunset yellow lake, erythrosine color lake, light blue color lake, iron oxide red, iron oxide yellow, titanium dioxide
One of which is several.It is preferred that titanium dioxide, this area is referred to as titanium dioxide.
Above-mentioned raw materials are pharmaceutical grade marketable material.
The model high shear mixers such as SRL, SHR, GH can be selected in mixer of the present invention, and (such as thin close Krona in river is public
Take charge of the mixer prepared)；Airslide disintegrating mill (such as Jiangsu close friend group system of the models such as QYF, YQ, QW can be used in airslide disintegrating mill
Standby airslide disintegrating mill).
Preferably, the production technology of film coating agent of the invention, comprises the following steps：
Step 1, filmogen is put into the mixer for having blade, mixer selects SRL, SHR or GH model high speed shear
Mixer, starts mixer, and the control of blade rotating speed is slowly added into plasticizer in 500-800r/min, equipment operation 6-15min,
Plasticizer is set to be fully infiltrated into filmogen；
Step 2, into mixer, input colouring agent is further mixed again, and blade rotating speed is controlled in 500-800r/min, if
Received shipment turns 10-20min, is well mixed three；
Step 3, the material input air flow pulverizer mixed, airslide disintegrating mill use the air-flow powder of QYF, YQ or QW model
Broken machine, the Stress control of compressed air is in 0.7-1.0MPa, and for material by after air-flow crushing in crushing chamber, its particle diameter is most of
Concentrate in 5-10 μ ms, obtain that color is uniform and the satisfactory coating agent finished product of particle diameter.
Test example
The process conditions such as rotating speed of the present invention, mixing time, air pressure etc. are obtained by screening, and screening process is such as
Under：
The rotating speed of test example 1 and the screening of time
The rotating speed of mixing paddle is set to 150r/min, 300r/min, 900r/min, 1100r/min by us, is added
Enter the incorporation time after colouring agent and be also set to 5min, 11min, 19min, 23min, carry out the plasticising and mixing of material, effect is shown in
Table 1 below
The rotating speed of table 1. and the screening of time
It can be seen that when the rotating speed of mixing paddle is relatively low, dispersion mixing is poor, and plasticizer is not completely dispersed into film forming
Material internal, material still some be moist agglomerate, colouring agent also disperses uneven, and time lengthening does not reach effect yet；
When the rotating speed of mixing paddle is increased to 200-1000r/min, contribute to material dispersion, powder color is substantially uniform；But after
The long-time that renews effect changes unobvious；But when the rotating speed of blade is more than 1000r/min, powder at a high speed with pot wall collide by rotation
Heating, material have ruckbildung.So it is determined that the process range effect of this patent selection is preferable.
The screening of the pressure of test example 2
The good material of above-mentioned preparation effect is crushed using airslide disintegrating mill, the pressure of compressed air is respectively 0.6MPa,
0.7MPa, 1.0MPa, 1.2MPa, crushing effect see the table below 2：
The screening of the pressure of table 2
| 0.6MPa | 0.7MPa | 1.0MPa | 1.2MPa | |
| Finished product grain size | 10—30μm | 1—20μm | 1—20μm | 1—20μm |
Due to crushing the pressure relied primarily in air-flow, the low crushing effect to material of air pressure is bad so that finished product grain size
It is larger, it is unsatisfactory for the requirement of our processing；And more than air pressure 1.0MPa finished product grain sizes and be not apparent from diminishing, more preferable effect is not played
Fruit, so Stress control is more suitable in 0.7-1.0MPa.
The gas flow crushing process of test example 3 and common process performance comparison
Common process：Method disclosed in ZL200910069076.9
Present invention process gas flow crushing process：Embodiment 1
Table 3 is gas flow crushing process and common process performance comparison
The advantages of the present invention
1st, plasticization effect is good.Liquid plasticizer can not be uniformly distributed using being added by the way of drenching in powder, can be in office
Portion forms the agglomerate of humidity, and other parts are still dry powder.Powder is set to produce motion, liquid using low velocity shear hybrid mode
When plasticizer sprays, reach preliminary with the powder of motion and mix, then penetrated into by the frictional impact of blade inside filmogen,
Form good plasticization effect.The slow-speed of revolution of blade will not also cause materials from spattering simultaneously.
2nd, product quality is more guaranteed.Colouring agent can shape using the mixing compared with the slow-speed of revolution in mixer with filmogen
Into preferable mixed effect, do not use high rotating speed to disperse, material can be avoided to introduce metal to blade and the power friction of pot wall miscellaneous
The situation of matter.And the further scattered and refinement in color lake uses air-flow crushing mode, because material is in high velocity air condition
Mutually collide down and crush, equipment surface will not be impacted, also free from admixture enters.After testing, the coating agent produced into
Product lead content is less than 0.5ppm, and the content of arsenic is less than 0.3ppm, and the heavy metal analysis of product meets the control of food, health products trade
System requires.
3rd, product cut size is thin and uniform.Airslide disintegrating mill is coated the principle that agent is processed：Compressed air is through crushing
Multiple nozzles of intracavitary inject disintegrating area after being accelerated into supersonic airstream, material is suspended in fluidized state and seethe with excitement and mutually collide
Hit, accelerated particle mutually clashes crushing in each nozzle joint, is fully opened the coloring agent particle of reunion, into membrane material
Bulky grain in material, which can also crush, to attenuate.Material after crushing is raised air-flow and is delivered to graded region, reaches the thin of granularity requirements
Powder is collected, and not up to the coarse powder of granularity requirements returns to disintegrating area and continues to crush.The method good crushing effect, particle diameter distribution are equal
Even, coating agent fineness can reach 1-20 μm, and the particle of wherein 5-10 μm particle diameter reaches more than 85%, illustrate to obtain using air-flow crushing
The material obtained has good fineness and the size distribution concentrated, the product cut size obtained better than original high shear process, and
Solves the problems, such as the heavy metal in product.Finished product grain size is uniform so that coating agent is in coating in use, solution dissolves rapid, face
Color is uniform, unilateral bright and clean after coating, no piebald and color dot.
4th, material heated denaturalization is avoided.Carried out using the mode of production in crushing process, high velocity air can take away material and hit
Caused heat is hit, so temperature of charge can be maintained at less than 30 DEG C all the time in production, there will not be the phenomenon of hot-spot, it is right
The situation that will not be melted or be denatured in the relatively low materiel machining of some fusing points.
5th, production efficiency is higher.Continuous work can be realized when being crushed using the mode of production, it is high without frequently charging discharging
Pressure gas stream can reach fast-crushing to material, and its speed of production than other production technologies faster, saves the production time.
Under
Embodiment
The present invention is further illustrated by the following examples, but not as limitation of the present invention.
Embodiment 1
1st, 850g hydroxypropyl methyl celluloses are added in mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min
Clock, slowly plus 60g enters glycerine, and equipment is run 6 minutes, reaches the plasticising to material.
2nd, 90g titanium dioxide is put into mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min, to cladding
Colouring agent afterwards carries out the mixing of 10 minutes, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 0.7MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Embodiment 2
1st, 610g methylcellulose is added in mixer, the blade rotating speed for controlling mixing apparatus is 600 revs/min, is delayed
Slow to add 160 castor oil, equipment is run 10.5 minutes, reaches the plasticising to material.
2nd, put into 190g titanium dioxide into mixer and 40g sunset yellow lakes, the blade rotating speed for controlling mixing apparatus are
600 revs/min, the mixing of 15 minutes is carried out to the colouring agent after cladding, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 0.85MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Embodiment 3
1st, 300g hydroxypropyl celluloses being added in mixer, the blade rotating speed for controlling mixing apparatus is 1000 revs/min,
200 triethyl citrates are slowly added into, equipment is run 15 minutes, reaches the plasticising to material.
2nd, put into 150g titanium dioxide into mixer and 350g medicinal iron oxides, the blade rotating speed for controlling mixing apparatus are
1000 revs/min, the mixing of 20 minutes is carried out to the colouring agent after cladding, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 1.0MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Embodiment 4
1st, 300g hydroxypropyl methyl celluloses are added in mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min
Clock, slowly plus 60g enters glycerine, and equipment is run 6 minutes, reaches the plasticising to material.
2nd, 90g titanium dioxide is put into mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min, to cladding
Colouring agent afterwards carries out the mixing of 10 minutes, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 0.7MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Embodiment 5
1st, 850g hydroxypropyl methyl celluloses are added in mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min
Clock, slowly plus 220g enters glycerine, and equipment is run 6 minutes, reaches the plasticising to material.
2nd, 500g titanium dioxide is put into mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min, to bag
Colouring agent after covering carries out the mixing of 10 minutes, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 0.7MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Embodiment 6
1st, 440g hydroxypropyl methyl celluloses are added in mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min
Clock, slowly plus 100g enters glycerine, and equipment is run 6 minutes, reaches the plasticising to material.
2nd, 170g titanium dioxide is put into mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min, to bag
Colouring agent after covering carries out the mixing of 10 minutes, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 0.7MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Embodiment 7
1st, 820g hydroxypropyl methyl celluloses are added in mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min
Clock, slowly plus 180g enters glycerine, and equipment is run 6 minutes, reaches the plasticising to material.
2nd, 380g titanium dioxide is put into mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min, to bag
Colouring agent after covering carries out the mixing of 10 minutes, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 0.7MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Embodiment 8
1st, 600g hydroxypropyl methyl celluloses are added in mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min
Clock, slowly plus 140g enters glycerine, and equipment is run 6 minutes, reaches the plasticising to material.
2nd, 280g titanium dioxide is put into mixer, the blade rotating speed for controlling mixing apparatus is 200 revs/min, to bag
Colouring agent after covering carries out the mixing of 10 minutes, forms mixture.
3rd, the material input air flow pulverizer mixed, compressed air pressure 0.7MPa, material is in crushing chamber by air-flow
After crushing, discharging obtains that color is uniform and the satisfactory coating agent finished product of particle diameter.
Claims (5)
1. a kind of production technology of film coating agent, comprises the following steps：
(1) take in filmogen input mixing apparatus and stir, rotating speed is in 500-800r/min, addition plasticizer operating 6-15min；
(2) colouring agent is added into mixing apparatus again, continues to stir, rotating speed in 500-800r/min, equipment operation 10-20min,
Obtain mixed material；
(3) mixed material is put into and crushed into airslide disintegrating mill, wherein pressure is 0.7-1.0MPa, and the particle diameter after crushing is
1-20μm；
Described plasticizer is selected from：It is one or more of in glycerine, castor oil, triethyl citrate；
The colouring agent is selected from：In sunset yellow lake, erythrosine color lake, light blue color lake, iron oxide red, iron oxide yellow, titanium dioxide
One or more；
Described mixer is with paddle mixer.
2. production technology as claimed in claim 1, it is characterised in that the filmogen described in step (1) is selected from：Hydroxypropyl
Methylcellulose, methylcellulose, hydroxypropyl cellulose, the one of which of polyacrylic resin.
3. production technology as claimed in claim 1, it is characterised in that the particle diameter described in step (3) is 5-10 μm.
4. the production technology as described in claim any one of 1-3, it is characterised in that described filmogen：Plasticizer：Coloring
Agent weight ratio is 30~85：6~22：9~50.
5. production technology as claimed in claim 4, it is characterised in that described filmogen：Plasticizer：Colourant weights ratio
For 44~82：10~18：17~38.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410763878.0A CN104548113B (en) | 2014-12-11 | 2014-12-11 | A kind of production technology of film coating agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410763878.0A CN104548113B (en) | 2014-12-11 | 2014-12-11 | A kind of production technology of film coating agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104548113A CN104548113A (en) | 2015-04-29 |
| CN104548113B true CN104548113B (en) | 2017-12-01 |
Family
ID=53065877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410763878.0A Active CN104548113B (en) | 2014-12-11 | 2014-12-11 | A kind of production technology of film coating agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104548113B (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197598A (en) * | 1998-05-01 | 1998-11-04 | 李伟 | Preparation of superfine powder seed-casing agent |
| CN1276158A (en) * | 2000-06-15 | 2000-12-13 | 江苏华农种衣剂有限责任公司 | Dry-powder seed coating agent and production method thereof |
| WO2006072832A1 (en) * | 2005-01-07 | 2006-07-13 | Pfizer Products Inc. | Fast-disintegrating dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene |
| CN101011051A (en) * | 2006-02-05 | 2007-08-08 | 武汉绿世纪生物工程有限责任公司 | Water dispersion granule for disinsection and disinfection |
| CN101238821A (en) * | 2007-02-07 | 2008-08-13 | 上海市农业科学院 | Flower small particle seed pill pelletizing formula and process method |
| CN101361979A (en) * | 2008-09-19 | 2009-02-11 | 天津博科林药品包装技术有限公司 | Solid preparation film coating agent and preparation method thereof |
| CN101559231A (en) * | 2009-06-01 | 2009-10-21 | 天津博科林药品包装技术有限公司 | High shearing production method for film coating agent |
| CN101569615A (en) * | 2009-06-01 | 2009-11-04 | 天津博科林药品包装技术有限公司 | Film coating agent used for exudative solid preparation and method for preparing same |
| CN103520733A (en) * | 2013-10-25 | 2014-01-22 | 天津博科林药品包装技术有限公司 | Coating agent capable of overcoming solution sedimentation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130267590A1 (en) * | 2011-09-13 | 2013-10-10 | Dr. Reddy's Laboratories Limited | Retigabine compositions |
-
2014
- 2014-12-11 CN CN201410763878.0A patent/CN104548113B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197598A (en) * | 1998-05-01 | 1998-11-04 | 李伟 | Preparation of superfine powder seed-casing agent |
| CN1276158A (en) * | 2000-06-15 | 2000-12-13 | 江苏华农种衣剂有限责任公司 | Dry-powder seed coating agent and production method thereof |
| WO2006072832A1 (en) * | 2005-01-07 | 2006-07-13 | Pfizer Products Inc. | Fast-disintegrating dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene |
| CN101011051A (en) * | 2006-02-05 | 2007-08-08 | 武汉绿世纪生物工程有限责任公司 | Water dispersion granule for disinsection and disinfection |
| CN101238821A (en) * | 2007-02-07 | 2008-08-13 | 上海市农业科学院 | Flower small particle seed pill pelletizing formula and process method |
| CN101361979A (en) * | 2008-09-19 | 2009-02-11 | 天津博科林药品包装技术有限公司 | Solid preparation film coating agent and preparation method thereof |
| CN101559231A (en) * | 2009-06-01 | 2009-10-21 | 天津博科林药品包装技术有限公司 | High shearing production method for film coating agent |
| CN101569615A (en) * | 2009-06-01 | 2009-11-04 | 天津博科林药品包装技术有限公司 | Film coating agent used for exudative solid preparation and method for preparing same |
| CN103520733A (en) * | 2013-10-25 | 2014-01-22 | 天津博科林药品包装技术有限公司 | Coating agent capable of overcoming solution sedimentation |
Non-Patent Citations (1)
| Title |
|---|
| 薄膜包衣技术及应用;盛春梁等;《食品与药品》;20070810;第09卷(第08期);第36-38页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104548113A (en) | 2015-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5393333A (en) | Film-forming product for coating solid forms, process for its manufacture and products coated with this film-forming product | |
| US5630871A (en) | Film coatings and film coating compositions based on cellulosic polymers and lactose | |
| DK174805B1 (en) | Colored powder coating compositions | |
| EP0551700B1 (en) | Film coatings and film coating compositions based on cellulosic polymers and lactose | |
| EP0771339B1 (en) | Dry moisture barrier film coating composition, method of coating substrates using the same and pharmaceutical tablets coated therewith | |
| JPH034577B2 (en) | ||
| TWI243845B (en) | Powder coating composition, manufacturing method thereof, and coating film obtained by using the composition | |
| WO2006016506A1 (en) | Modified powder, fluid composition containing said modified powder, formed article, and method for producing modified powder | |
| US8388983B2 (en) | Film coatings containing fine particle size detackifiers and substrates coated therewith | |
| CN107384170B (en) | It is a kind of aluminum paint, aqueous and preparation method thereof | |
| CN107841049A (en) | A kind of polypropene composition of heat discoloration and its preparation method and application | |
| CN104548113B (en) | A kind of production technology of film coating agent | |
| WO2012120364A2 (en) | Novel immediate release film coating compositions | |
| CN110054990A (en) | High-temperature-resistant powder coating and preparation method thereof | |
| CN108546367A (en) | A kind of high dispersive flame-proof ABS Masterbatch and preparation method thereof | |
| CN101559231B (en) | High shearing production method for film coating agent | |
| CN106085160A (en) | A kind of environmentally friendly alkide resin emulsion of zero VOC content and preparation method thereof | |
| CN109988490A (en) | A kind of antibacterial sublimation transfer wood grain powder paint compositions | |
| CN106336864A (en) | Preparing technology for organic coating of zinc-sulfide long-afterglow luminescent powder | |
| CN114381170B (en) | Soft oil painting stick and preparation method thereof | |
| CN106085231A (en) | A kind of thermoprint aqueous mould release and preparation method thereof | |
| CN103122184A (en) | Production method of mothproof and fireproof paint for trees | |
| CN106189617A (en) | High temperature resistant plastic-wood material compositions and high temperature resistant mould wood and preparation method thereof | |
| CN108676404B (en) | High-imitation metal powder coating and preparation method thereof | |
| CN110637817A (en) | Pesticide composition based on niclosamide ethanolamine salt and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |