CN104547862A - Use of traditional Chinese medicine preparation in preparation of medicine for treating bone fracture - Google Patents
Use of traditional Chinese medicine preparation in preparation of medicine for treating bone fracture Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to the use of a traditional Chinese medicine preparation in the preparation of a medicine for treating bone fracture. The traditional Chinese medicine preparation is prepared by performing a special preparation process on the traditional Chinese medicinal materials: astragalus membranaceus, Chinese yam, radix rehmanniae preparata, Chinese wolfberries, cuscuta chinensis, rhizoma atractylodis macrocephalae, colla corii asini, cortex eucommiae, cornus officinalis, radix dipsaci, fructus amomi, dried orange peel, Chinese angelica, Chinese taxillus twig, rhizoma cimicifugae, herba leonuri, desertliving cistanche, cyperus rotundus, radix paeoniae alba, radix liquiritiae and the like. The traditional Chinese medicine preparation has the effects of replenishing blood, activating the blood, promoting the circulation of qi, dispelling melancholy, activating the blood to remove stasis, eliminating stasis, relieving pain and the like, and has a very remarkable treatment effect on the bone fracture; the traditional Chinese medicine preparation also has a remarkable treatment effect on cervical spondylosis; moreover, the traditional Chinese medicine preparation provided by the invention can be developed into a finished preparation which is convenient to take, and is high in universal applicability, simple in production process and easy to popularize and apply.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the preparation of the purposes in treatment fracture medicine.
Background technology
Fracture is that the seriality of bone structure ruptures wholly or in part, be the external force such as wound, traumatic injury and cause bone injury, fracture, comminuted caused a kind of disease.Its clinical main manifestations is: fractures has localized pain and tenderness; local swelling and occur ecchymosis; limb function position or completely lose; still can there is cacomelia and abnormal movement in completeness sclerotin; fracture not only brings huge pain to patient; also there will be a series of complication; such as heating paresthesia; and patient Chang Yin widely soft tissue injury, bleed profusely, have an intense pain or concurrent visceral injury etc. and cause the phenomenon of shock; cause the damage of around vital tissue, blood vessel and nerve, have a strong impact on the healthy of patient.
Up to now, the Therapeutic Method of general doctor trained in Western medicine is suited the remedy to the case, anti-inflammatory analgetic, interim control pain, but this Therapeutic Method can produce dependency to medicine, and side effect is larger, larger harm is existed to the health of patient, also have at present to adopt and be aided with medicine for external use in necessity by after reduction with clamping plate or Gypsum Fibrosum extenal fixation, but, larger misery can be brought to patient like this, healing rate is comparatively slow, and curative effect is only desirable.Therefore, find a kind of heal fractures successful, the little medicine of side effect is the current problem needing solution badly.
Cervical spondylosis is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, one of middle-aged and elderly people and office's white collar commonly encountered diseases frequently-occurring disease, cervical spondylosis is chronic strain mainly, the damage of long-term local muscle, ligament, joint capsule causes, cervical spondylosis not only brings great pain to patient, has a strong impact on the life of patient simultaneously.Mainly there is operative treatment and non-operative treatment two kinds in the treatment of current cervical spondylosis, operative treatment exists the shortcoming of medical expense costliness, is unfavorable for the use of extensive patients.Non-operative treatment comprises the methods such as Chinese and western drugs, acupuncture, massage, physical therapy, traction, and Western medicine medicine is usually rapid-action, but effect is difficult to lastingly, needs long-term prescription, has a strong impact on the healthy of patient.
Summary of the invention
In order to the medication effect solving prior art treatment fracture is not obvious, therapeutic effect is difficult to continue, the defect that toxic and side effects is large, an object of the present invention there is provided a kind of Chinese medicine preparation for the preparation of the purposes in treatment fracture medicine.
In order to solve first technical problem, inventor according to oneself from clinical experience for many years, traditional proved recipe and secret prescription handed down in the family from generation to generation are fully transformed and utilized, and according to the ill feature of contemporary people with adapt to industrial needs, carry out increase and decrease medical material and dose, again scientific compatibility medical material, and grope through clinical checking repeatedly, finally obtain a very significant Chinese prescription for the treatment of fracture effect, this Chinese prescription with parts by weight is:
Radix Astragali 16-24 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 14-22 part, Radix Rehmanniae Preparata 14-22 part, Fructus Lycii 6-14 part, Semen Cuscutae 11-19 part, Rhizoma Atractylodis Macrocephalae 6-14 part, Colla Corii Asini 8-16 part, Cortex Eucommiae 11-19 part, Fructus Corni 14-22 part, Radix Dipsaci 6-14 part, Fructus Amomi 6-14 part, Pericarpium Citri Reticulatae 3-12 part, Radix Angelicae Sinensis 11-19 part, Herba Taxilli 6-14 part, Rhizoma Cimicifugae 3-12 part, Herba Leonuri 16-24 part, Herba Cistanches 8-16 part, Rhizoma Cyperi 4-12 part, Radix Paeoniae Alba 6-14 part, Radix Glycyrrhizae 6-14 part.
The excellent therapeutic effect that has found in practice is respectively with the proportioning of parts by weight:
The Radix Astragali 20 parts, RHIIZOMA DIOSCOREAE fr0m Henan of China 18 parts, 18 parts, Radix Rehmanniae Preparata, Fructus Lycii 10 parts, Semen Cuscutae 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 12 parts, Colla Corii Asini, the Cortex Eucommiae 15 parts, Fructus Corni 18 parts, Radix Dipsaci 10 parts, Fructus Amomi 10 parts, Pericarpium Citri Reticulatae 7 parts, Radix Angelicae Sinensis 15 parts, Herba Taxilli 10 parts, Rhizoma Cimicifugae 7 parts, Herba Leonuri 20 parts, Herba Cistanches 12 parts, Rhizoma Cyperi 8 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Radix Glycyrrhizae.
Two of object of the present invention is to provide the method for this Chinese medicine preparation of preparation, inventor adjusts through prescription, the processing procedure of repetition test ingredients and extraction process, and in conjunction with modern pharmaceutical technological invention a set of preparation technology, this technological operation is easy, preparation stabilization, guarantee drug effect, be easy to apply.Said preparation technique is following steps:
Step 1, get Radix Astragali processed with honey method, fry to tack-free, for subsequent use; Get the Rhizoma Atractylodis Macrocephalae, Cortex Eucommiae parched with bran, for subsequent use;
Step 2, take the Radix Astragali, Radix Rehmanniae Preparata, Fructus Lycii, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, the Cortex Eucommiae, Rhizoma Cimicifugae, the Radix Paeoniae Alba 8 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the ethanol of 65% of 8 times of weight, soaks 20 hours, reflux 2 hours, filtration; Filtering residue adds the ethanol of 65% of 6 times of initial medical material weight, reflux 2 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution A, for subsequent use;
Step 3, take RHIIZOMA DIOSCOREAE fr0m Henan of China, Colla Corii Asini, Fructus Corni, Radix Dipsaci, Fructus Amomi, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Herba Taxilli, Herba Leonuri, Herba Cistanches, Rhizoma Cyperi, Radix Glycyrrhizae 12 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the purified water of 8 times of weight, backflow decoction 3 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 2 hours, filters, and by twice filtrate mixing, 1/5 of simmer down to original volume, is extracting solution B;
Step 4, by extracting solution A, B mix, being concentrated into density is 1.30(70 DEG C of survey), be Chinese medical concrete;
Step 5, Chinese medical concrete is added adjuvant make finished product Chinese medicine preparation.
Chinese medicine preparation of the present invention can make granule or capsule.
The source of Chinese Herbs Medicines raw material of the present invention, character and function:
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali.Sweet in the mouth, warm in nature; Return lung, spleen channel; Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
RHIIZOMA DIOSCOREAE fr0m Henan of China: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.
Radix Rehmanniae Preparata: this product is the Preparation process product of Radix Rehmanniae.Sweet in the mouth, slightly warm in nature; Return liver, kidney channel; Nourishing YIN and supplementing blood, beneficial essence fills out marrow.
Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum.Sweet in the mouth, property is put down; Return liver, kidney channel; Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant.Sweet in the mouth, warm in nature; Return liver,kidney,spleen warp; Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp; Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.
Colla Corii Asini: this product is that the skin of equine species donkey is through decocting, concentrating the solid gum made.Sweet in the mouth, property is put down; Return lung, liver, kidney channel; To enrich blood YIN nourishing, moisturize, hemostasis.
The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae.Sweet in the mouth, warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Fructus Corni: this product is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni.Sour in the mouth, puckery, slightly warm in nature; Return liver, kidney channel; Liver and kidney tonifying, essence astringing and desertion stemming.
Radix Dipsaci: this product is the dry root of Dipsacaceae plant Radix Dipsaci.Bitter in the mouth, pungent, slightly warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA.Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.
Pericarpium Citri Reticulatae: be the mature peel of rutaceae orange and variety thereof.Bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Herba Taxilli: this product is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli.Taste, sweet, property is put down; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.
Rhizoma Cimicifugae: this product is the dry rhizome of ranunculaceae plant C.heracleifolia, Cimicifuga Dahurica or Rhizoma Cimicifugae.Acrid in the mouth, micro-sweet, cold nature; Return lung, spleen, stomach, large intestine channel; Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Herba Leonuri: this product is the fresh of labiate Herba Leonuri or dry aerial parts.Bitter in the mouth, pungent, cold nature; Return liver, pericardium channel; Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.
Herba Cistanches: this product is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche.Sweet in the mouth, salty, warm in nature; Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
Rhizoma Cyperi: this product is the dry rhizome of sedge dried tuber.Acrid in the mouth, micro-hardship, micro-sweet, property is put down; Return liver, spleen, tri-jiao channel; Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae.Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese medicine of the present invention:
According to the compatibility theory of the traditional Chinese medical science to the dialectical and Chinese crude drug of fracturing, in conjunction with the body constitution of modern and the feature of modern pharmaceutical technology, the collocation ingredients of reasonable science, form Chinese prescription of the present invention, this prescription is with the Radix Astragali, RHIIZOMA DIOSCOREAE fr0m Henan of China, Fructus Corni, Radix Rehmanniae Preparata, Herba Leonuri, Radix Dipsaci for monarch drug, invigorating QI to consolidate the body surface resistance, blood circulation promoting and blood stasis dispelling, eliminating stasis to stop pain, promoting blood flow to regulate menstruation; With Fructus Lycii, Semen Cuscutae, Herba Cistanches, the Cortex Eucommiae, Colla Corii Asini, for ministerial drug, YIN nourishing of enriching blood, stopping pain and expelling blood stasis; With the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Herba Taxilli for adjuvant drug, invigorating the spleen and benefiting QI, enrich blood and invigorate blood circulation; With Fructus Amomi, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Rhizoma Cyperi for making medicine, regulating qi-flowing for strengthening spleen, elevate a turnable ladder yang-energy, promoting QI circulation for relieving depression; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicine of monarch is coordinated, collaboratively to promote, complement each other, finally reaching enriches blood invigorates blood circulation, promoting QI circulation for relieving depression, blood circulation promoting and blood stasis dispelling, the effect such as eliminating stasis to stop pain, thus to fracture, there is very significant therapeutic effect.
Prove through effect experiment, Chinese medicine preparation of the present invention can also treat cervical spondylosis, and therapeutic effect is obvious, and toxic and side effects is little, and the therapeutic effect persistent period is long, alleviates the misery of vast Patients with Cervical Spondylopathy.
Compared with prior art, Chinese medicine preparation of the present invention has good effect, has no side effect, conditioning effect is remarkable, and Chinese medicine preparation of the present invention is natural pure Chinese medicinal preparation, untoward reaction is little, effect comprehensively, and after being developed to the finished product preparation conveniently taken, general applicability is good, curative effect is still remarkable, and production technology is simple, is easy to apply.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but those skilled in the art should know, described embodiment does not also limit the present invention in any way.
the granule preparation of embodiment 1, Chinese medicine preparation of the present invention
Step 1, get Radix Astragali processed with honey method, fry to tack-free, for subsequent use; Get the Rhizoma Atractylodis Macrocephalae, Cortex Eucommiae parched with bran, for subsequent use;
Step 2, take the 16kg Radix Astragali, 14kg Radix Rehmanniae Preparata, 6kg Fructus Lycii, 11kg Semen Cuscutae, the 6kg Rhizoma Atractylodis Macrocephalae, the 11kg Cortex Eucommiae, 3kg Rhizoma Cimicifugae, the 6kg Radix Paeoniae Alba 8 taste medical material, pulverize respectively, mixing, add the ethanol of 65% of 8 times of weight, soak 20 hours, reflux 2 hours, filter; Filtering residue adds the ethanol of 65% of 6 times of initial medical material weight, reflux 2 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution A, for subsequent use;
Step 3, take 14kg RHIIZOMA DIOSCOREAE fr0m Henan of China, 8kg Colla Corii Asini, 14kg Fructus Corni, 6kg Radix Dipsaci, 6kg Fructus Amomi, 3kg Pericarpium Citri Reticulatae, 11kg Radix Angelicae Sinensis, 6kg Herba Taxilli, 16kg Herba Leonuri, 8kg Herba Cistanches, 4kg Rhizoma Cyperi, 6kg Radix Glycyrrhizae 12 taste medical material, pulverize respectively, mixing, add the purified water of 8 times of weight, backflow decoction 3 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 2 hours, filters, and by twice filtrate mixing, 1/5 of simmer down to original volume, is extracting solution B;
Step 4, by extracting solution A, B mix, being concentrated into density is 1.30(70 DEG C of survey), be Chinese medical concrete;
Step 5, Chinese medical concrete is added adjuvant make granule.
the capsule preparation of embodiment 2, Chinese medicine preparation of the present invention
Step 1, get Radix Astragali processed with honey method, fry to tack-free, for subsequent use; Get the Rhizoma Atractylodis Macrocephalae, Cortex Eucommiae parched with bran, for subsequent use;
Step 2, take the 20kg Radix Astragali, 14kg Radix Rehmanniae Preparata, 10kg Fructus Lycii, 15kg Semen Cuscutae, the 10kg Rhizoma Atractylodis Macrocephalae, the 15kg Cortex Eucommiae, 7kg Rhizoma Cimicifugae, the 10kg Radix Paeoniae Alba 8 taste medical material, pulverize respectively, mixing, add the ethanol of 65% of 8 times of weight, soak 20 hours, reflux 2 hours, filter; Filtering residue adds the ethanol of 65% of 6 times of initial medical material weight, reflux 2 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution A, for subsequent use;
Step 3, take 18kg RHIIZOMA DIOSCOREAE fr0m Henan of China, 12kg Colla Corii Asini, 18kg Fructus Corni, 10kg Radix Dipsaci, 10kg Fructus Amomi, 7kg Pericarpium Citri Reticulatae, 15kg Radix Angelicae Sinensis, 10kg Herba Taxilli, 20kg Herba Leonuri, 12kg Herba Cistanches, 8kg Rhizoma Cyperi, 10kg Radix Glycyrrhizae 12 taste medical material, pulverize respectively, mixing, add the purified water of 8 times of weight, backflow decoction 3 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 2 hours, filters, and by twice filtrate mixing, 1/5 of simmer down to original volume, is extracting solution B;
Step 4, by extracting solution A, B mix, being concentrated into density is 1.30(70 DEG C of survey), be Chinese medical concrete;
Step 5, Chinese medical concrete is added adjuvant make capsule.
the capsule preparation of embodiment 3, Chinese medicine preparation of the present invention
Step 1, get Radix Astragali processed with honey method, fry to tack-free, for subsequent use; Get the Rhizoma Atractylodis Macrocephalae, Cortex Eucommiae parched with bran, for subsequent use;
Step 2, take the 24kg Radix Astragali, 22kg Radix Rehmanniae Preparata, 14kg Fructus Lycii, 19kg Semen Cuscutae, the 14kg Rhizoma Atractylodis Macrocephalae, the 19kg Cortex Eucommiae, 12kg Rhizoma Cimicifugae, the 14kg Radix Paeoniae Alba 8 taste medical material, pulverize respectively, mixing, add the ethanol of 65% of 8 times of weight, soak 20 hours, reflux 2 hours, filter; Filtering residue adds the ethanol of 65% of 6 times of initial medical material weight, reflux 2 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution A, for subsequent use;
Step 3, take 22kg RHIIZOMA DIOSCOREAE fr0m Henan of China, 16kg Colla Corii Asini, 22kg Fructus Corni, 14kg Radix Dipsaci, 14kg Fructus Amomi, 12kg Pericarpium Citri Reticulatae, 19kg Radix Angelicae Sinensis, 14kg Herba Taxilli, 24kg Herba Leonuri, 16kg Herba Cistanches, 12kg Rhizoma Cyperi, 14kg Radix Glycyrrhizae 12 taste medical material, pulverize respectively, mixing, add the purified water of 8 times of weight, backflow decoction 3 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 2 hours, filters, and by twice filtrate mixing, 1/5 of simmer down to original volume, is extracting solution B;
Step 4, by extracting solution A, B mix, being concentrated into density is 1.30(70 DEG C of survey), be Chinese medical concrete;
Step 5, Chinese medical concrete is added adjuvant make capsule.
embodiment 4, Chinese medicine preparation of the present invention are on the impact of White Rabbit fracture model
one, test material
1, experimental animal: White Rabbit, male, 2.2-2.6kg, by Changsha, Rui Ling agricultural science and technology company limited provides.
2, instrument: Hitachi 7020 automatic clinical chemistry analyzer, Japanese Hitachi company.Absorptiometry (Piximus bone densito-meter, LUNAR company of the U.S.)
3, trial drug: Yunnan Baiyao Capsule, Yunnan Paiyao Group Corp., Ltd, every dress 0.25g;
Capsule prepared by the embodiment of the present invention 2.
two, test method:
1, animal grouping: get White Rabbit 50, be divided into 5 groups at random, often organizes 10, is respectively model group (equal-volume distilled water), YUNNAN BAIYAO positive group, low dose group, middle dosage group and high dose group.Each group of administering mode is as described below:
Model group: gavage gives the distilled water of same volume;
The positive group of YUNNAN BAIYAO: gavage gives Yunnan Baiyao Capsule 0.15g/kg.d;
Low dose group: gavage gives the embodiment of the present invention 2 and prepares capsule 0.05g/kg.d
Middle dosage group: gavage gives the embodiment of the present invention 2 and prepares capsule 0.15g/kg.d
High dose group: gavage gives the embodiment of the present invention 2 and prepares capsule 0.3g/kg.d.
2, the preparation of animal model: after White Rabbit adaptability raises a week, after White Rabbit is anaesthetized according to 1ml/kg dose intravenous with 3% Nembutal sodium solution, both sides forelimb cropping, 75% alcohol disinfecting, is aseptically widely about 3mm with horizontal being drilled to of medical operation dental burr epimere 1/3 intersection in the radius of both sides, go deep into medullary cavity and form bone injury, skin suture, Post operation starts gastric infusion, successive administration next day, within after administration the 14th, 28 day, get 7 in each group of White Rabbit, measure indices.
3, bone densitometry: intercepted both sides radius respectively at after administration the 14th, 28 day, its length comprises damage and each normal reach sclerotin up and down, measures bone density, observe union of fracture situation with LUNAR company of U.S. Piximus bone densito-meter analyzer.
three, result of the test
Result of the test shows (specifically in table 1): give capsule of the present invention continuously after 14 days, and the bone density of YUNNAN BAIYAO positive group and low middle high three the dosage groups of the present invention increases, and has significant difference (p<0.05) compared with model group.Administration is after 28 days, the positive group of YUNNAN BAIYAO has pole significant difference (p<0.01) compared with model group, the present invention is low, and middle high three dosage groups have significant difference (p<0.05) compared with model group, and the bone density of the bone density of 28 days than 14 days increases, result shows that Chinese medicine preparation of the present invention has and accelerates bone ore deposit sedimentation rate, improve bone density, promote the function of fracture site healing.
table 1 Chinese medicine preparation of the present invention is on the impact of White Rabbit fracture model bone density
▲compared with model group, p<0.05;
▲ ▲compared with model group, p<0.01.
embodiment 8, Chinese medicine preparation of the present invention are tested the clinical effectiveness of cervical spondylosis
1, subjects data
Experimenter is all from treatment cervical spondylosis hospital of certain city, that accepts for medical treatment in December, 2012 to 2013 year December for this hospital suffers from Patients with Cervical Spondylopathy, therefrom select the patient 210 of applicable clinical trial, wherein male 140, women 70, age 40-60 year, the short person 4-5 of sick time month, elder 6-8.Patients with Cervical Spondylopathy is divided at random A group, B group and C group, often organizes 70 people.
2, trial drug
Trial drug is capsule prepared by the embodiment of the present invention 2.
3, test method
Capsule prepared by the oral embodiment of the present invention 2 of A, B, C tri-group difference, 2g/ time, every day 3 times, 3 months courses for the treatment of.Treatment terminates all patients of rear return visit, the situation of statistics Patients with Cervical Spondylopathy.
4, test evaluation standard
All patients all make a definite diagnosis through X-ray photograph or CT examination, and make a definite diagnosis in conjunction with patients symptomatic.
5, clinical symptoms
The clinical symptoms of Patients with Cervical Spondylopathy has: dizziness, restriction of neck motion shoulder pain, dizzy vomiting, body soft unable, have nape pain, upper myasthenia of limbs, point the symptoms such as numb, numbness of lower limbs and lower limb moving difficulty.
6, criterion of therapeutical effect
(1) cure: without the clinical symptoms of cervical spondylosis, without the need to treating again.。
(2) effective: related symptoms partial disappearance, health takes a turn for the better, but still needs treatment further.
(3) invalid: related symptoms is without any improvement, even more serious.
7, therapeutic effect
Table 2 embodiment of the present invention 2 capsule treatment cervical spondylosis effect table
8, conclusion (of pressure testing)
In this experiment 210 Patients with Cervical Spondylopathies, the average cure rate of the embodiment of the present invention 2 capsule 3 test group is 88.6%, and total effective rate is 100%, and therapeutic effect is remarkable, without there is toxic and side effects, prove that Chinese medicine preparation of the present invention has significant therapeutic effect to cervical spondylosis.
Claims (5)
1. Chinese medicine preparation is for the preparation of the purposes in treatment fracture medicine, and it is characterized in that, described Chinese medicine preparation with the Chinese prescription of parts by weight is:
Radix Astragali 16-24 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 14-22 part, Radix Rehmanniae Preparata 14-22 part, Fructus Lycii 6-14 part, Semen Cuscutae 11-19 part, Rhizoma Atractylodis Macrocephalae 6-14 part, Colla Corii Asini 8-16 part, Cortex Eucommiae 11-19 part, Fructus Corni 14-22 part, Radix Dipsaci 6-14 part, Fructus Amomi 6-14 part, Pericarpium Citri Reticulatae 3-12 part, Radix Angelicae Sinensis 11-19 part, Herba Taxilli 6-14 part, Rhizoma Cimicifugae 3-12 part, Herba Leonuri 16-24 part, Herba Cistanches 8-16 part, Rhizoma Cyperi 4-12 part, Radix Paeoniae Alba 6-14 part, Radix Glycyrrhizae 6-14 part.
2. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation with the Chinese prescription of parts by weight is:
The Radix Astragali 20 parts, RHIIZOMA DIOSCOREAE fr0m Henan of China 18 parts, 18 parts, Radix Rehmanniae Preparata, Fructus Lycii 10 parts, Semen Cuscutae 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 12 parts, Colla Corii Asini, the Cortex Eucommiae 15 parts, Fructus Corni 18 parts, Radix Dipsaci 10 parts, Fructus Amomi 10 parts, Pericarpium Citri Reticulatae 7 parts, Radix Angelicae Sinensis 15 parts, Herba Taxilli 10 parts, Rhizoma Cimicifugae 7 parts, Herba Leonuri 20 parts, Herba Cistanches 12 parts, Rhizoma Cyperi 8 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Radix Glycyrrhizae.
3. purposes as claimed in claim 1 or 2, it is characterized in that, the preparation method of described Chinese medicine preparation, comprises the following steps:
Step 1, get Radix Astragali processed with honey method, fry to tack-free, for subsequent use; Get the Rhizoma Atractylodis Macrocephalae, Cortex Eucommiae parched with bran, for subsequent use;
Step 2, take the Radix Astragali, Radix Rehmanniae Preparata, Fructus Lycii, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, the Cortex Eucommiae, Rhizoma Cimicifugae, the Radix Paeoniae Alba 8 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the ethanol of 65% of 8 times of weight, soaks 20 hours, reflux 2 hours, filtration; Filtering residue adds the ethanol of 65% of 6 times of initial medical material weight, reflux 2 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution A, for subsequent use;
Step 3, take RHIIZOMA DIOSCOREAE fr0m Henan of China, Colla Corii Asini, Fructus Corni, Radix Dipsaci, Fructus Amomi, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Herba Taxilli, Herba Leonuri, Herba Cistanches, Rhizoma Cyperi, Radix Glycyrrhizae 12 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the purified water of 8 times of weight, backflow decoction 3 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 2 hours, filters, and by twice filtrate mixing, 1/5 of simmer down to original volume, is extracting solution B;
Step 4, by extracting solution A, B mix, being concentrated into density is that 1.30(is 70 DEG C of surveys), be Chinese medical concrete;
Step 5, Chinese medical concrete is added adjuvant make finished product Chinese medicine preparation.
4. the purposes as described in as arbitrary in claim 1-3, it is characterized in that, described Chinese medicine preparation makes granule or capsule.
5. the purposes as described in as arbitrary in claim 1-4, is characterized in that, described Chinese medicine preparation is for the preparation of the purposes for the treatment of cervical spondylosis.
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