CN104547834A - Agent capable of improving intelligence level of patients suffering from intellectual disability - Google Patents
Agent capable of improving intelligence level of patients suffering from intellectual disability Download PDFInfo
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Abstract
The invention discloses an agent capable of improving intelligence level of patients suffering from intellectual disability. The agent is prepared from the following raw material medicines in parts by weight: 10-20 parts of gorgon fruits, 15-30 parts of lotus leaf, 15-20 parts of gray polypody, 15-30 parts of cassia twig, 9-15 parts of stone-like omphalia, 8-16 parts of flickingeria comata, 20-30 parts of semen sesami nigrum, 15-20 parts of angelica sinensis, 15-30 parts of poria with hostwood, 3-6 parts of ruddle, 5-9 parts of digua fig stem and leaf, 8-12 parts of longstalk condorvine herb, 8-12 parts of fructus viticis, 15-30 parts of wolfberry and 15-30 parts of fructus alpiniae oxyphyllae. The agent disclosed by the invention has the excellent effects that the traditional medicine properties and the modern pharmacology of traditional Chinese medicine are organically combined, the drugs are used to form a prescription, and the curative effect is improved; the traditional Chinese medicine has the effects of nourishing liver and kidney, benefiting qi for activating blood circulation and invigorating the brain and improving the intelligence, is capable of obviously improving the intelligence level of the patients suffering from intellectual disability, is safe and does not have any side effect; and moreover, the drug source is readily available, the cost of the medicinal materials is low, and the burdens of patients can be alleviated.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of medicament contributing to improving disturbance of intelligence patient level of intelligence.
Background technology
Intelligence is exactly that a people uses the knowledge experience in the past accumulated to solve the ability of current physical presence problem.It shows as attention, memory, faculty of understanding, computing power, comprehensive analytical capacity and creativity etc.It just can must show in the process solving certain problem, and because of the difficulty of problem, different in kind and need different abilities.But the growth of intelligence and play and have substantial connection with social environment and education, good education is conducive to the growth of intelligence, but is not the single factor determining level of intelligence height, factors such as age, schooling, occupation and position and intelligently have certain contacting.In a word, the general ability carrying out wisdom activity is intelligence.
Disturbance of intelligence is exactly that the ability development carrying out wisdom activity is hindered or produces defect, cause the individual adaptation to environment difficulty occurs and shows mentally disabled, or make because of the disseminated lesions of brain structure patient background clearly occur lasting, comprehensive hypophrenia realizing.Common disturbance of intelligence has the following aspects: (1) mental retardation or mental retardation: mainly patient period of fetus, birth time or cradle; the growth course of brain due to heredity, infect, the factor such as poisoning, head trauma, cryptorrhea or anoxia and being hindered; so that brain development is bad; or blocked, make the growth of intelligence rest on certain stage.(2) dull-witted; (3) pseudodementia.The origin cause of formation of disturbance of intelligence is divided into the congenital and day after tomorrow two kinds.Inborn disturbance of intelligence may be due to chromosomal abnormality; The posteriori origin cause of formation may be then that brain sustains damage (such as: traffic accident), or is subject to the stimulation of outward thing.Promote cerebral metabolism this year, improve the Western medicine drug of brain function and develop to some extent, such as cerebrolysin, piracetam etc., drug effect is obvious; The traditional Chinese medical science think the five internal organs impaired with can not cause mental retardation completely, impaired and not enough according to internal organs, carrying out differentiation of symptoms and signs for classification of syndrome treatment, is traditional method for the treatment of of primary disease.
Publication number CN 1943749 A(application number 200510105946.5) Chinese invention patent document disclose one and treat children mental retardation Chinese medicine composition and preparation method thereof, it is made up of the crude drug of following weight ratio: Radix Ginseng 2-6, Fructus Alpiniae Oxyphyllae 4-12, Pericarpium Citri Reticulatae Viride 1-3, Carapax et Plastrum Testudinis 2-6, Fructus Lycii 2-6, Herba Menthae 0.5-2.Publication number CN 1943681 A(application number 200510107841.3) Chinese invention patent document disclose one and treat children mental retardation Chinese medicine composition and preparation method thereof, it is made up of the crude drug of following weight ratio: Radix Panacis Quinquefolii 30-80, Radix Et Caulis Acanthopanacis Senticosi extractum 10-30, Carapax et Plastrum Testudinis(processed with vinegar) 70-150, Ganoderma 100-200, Rhizoma Acori Graminei 70-150, Radix Polygalae (processed) 70-150, Radix Polygoni Multiflori Preparata 70-150, Fructus Schisandrae Chinensis 30-80, zinc gluconate 0.5-2.Application publication number CN 102416134 A(application number 201110411013.4) Chinese invention patent document disclose a kind of medicine and preparation method for the treatment of mental retardation of children, make in the crude drug by following weight portion: Fructus Mori 20-50, Arillus Longan 20-25, Fructus Lycii 10-18, Radix Polygalae 20-30, Radix Ginseng 2-5, Semen Armeniacae Amarum 6-15, Rhizoma Dioscoreae 20-25, Isodon ternifolius 50-80, Radix Puerariae 5-8, Concha Arcae 10-15, Pericarpium Citri Reticulatae 5-15, Radix Codonopsis 10-20, Colla cornus cervi 20-25, Colla Corii Asini 5-8, Fructus Alpiniae Oxyphyllae 20-30, Semen Cuscutae 5-10.
At present, Western medicine there is no the specific drug for the treatment of disturbance of intelligence, and Chinese medicine, from differential diagnosis of diseases and the dialectical thinking combined, adopts specially side to discuss the Therapeutic Method controlled and achieves significant curative effect in clinical research and treatment, and Chinese medicine safely, have no side effect, prospect is very wide.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare the medicament simply, conveniently taking, contribute to safely and effectively improving disturbance of intelligence patient level of intelligence.This curative effect of medicine is remarkable, without any side effects.
Technical scheme of the present invention is:
Contribute to the medicament improving disturbance of intelligence patient level of intelligence, be prepared from by following bulk drugs, be weight portion: Semen Euryales 10-20; Folium Nelumbinis 15-30; Rhizoma Polypodiodis Nipponicae 15-20; Ramulus Cinnamomi 15-30; Omphalia 9-15; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 8-16; Semen Sesami Nigrum 20-30; Radix Angelicae Sinensis 15-20; Poria cum Radix Pini 15-30; Haematitum 3-6; Caulis et Folium fici Tikouae 5-9; Radix Marsdeniae Longipedis 8-12; Fructus Viticis 8-12; Fructus Lycii 15-30; Fructus Alpiniae Oxyphyllae 15-30.
In preferred scheme, Semen Euryales 14-16; Folium Nelumbinis 20-25; Rhizoma Polypodiodis Nipponicae 17-18; Ramulus Cinnamomi 20-25; Omphalia 10-13; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10-14; Semen Sesami Nigrum 23-27; Radix Angelicae Sinensis 17-18; Poria cum Radix Pini 20-25; Haematitum 4-5; Caulis et Folium fici Tikouae 6-8; Radix Marsdeniae Longipedis 9-11; Fructus Viticis 9-11; Fructus Lycii 20-25; Fructus Alpiniae Oxyphyllae 20-25.
Be more preferably, Semen Euryales 15; Folium Nelumbinis 22.5; Rhizoma Polypodiodis Nipponicae 17.5; Ramulus Cinnamomi 22.5; Omphalia 11.5; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 12; Semen Sesami Nigrum 25; Radix Angelicae Sinensis 17.5; Poria cum Radix Pini 22.5; Haematitum 4.5; Caulis et Folium fici Tikouae 7; Radix Marsdeniae Longipedis 10; Fructus Viticis 10; Fructus Lycii 22.5; Fructus Alpiniae Oxyphyllae 22.5.
Contribute to the medicament improving disturbance of intelligence patient level of intelligence, the preparation method of described oral liquid is as follows:
(1) Ramulus Cinnamomi adds clear water and is dipped to epidermis deliquescing, and removing epidermis, cleans, section, and put in smokeless stove fire, heating is dried, and have black speck to surperficial buff, taking-up cools, and grinds for subsequent use; Rhizoma Polypodiodis Nipponicae and Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. are cleaned, and join in the salt grain made popular, and it is buff slightly focal spot that slow fire heating continues to stir-fry to medical material surface, takes out, lets cool, grind for subsequent use; Haematitum is placed in the fine grinding of white beeswax water, outwells water layer, three times repeatedly, to water layer redfree, leaves standstill, filtered through gauze, dry, continues to grind to form fine powder, for subsequent use; By gained fine powder, mixing, sieves, loads in penetrating bag, for subsequent use;
(2) get refined honey to add water and make old honey, join in the Fructus Alpiniae Oxyphyllae of clean system, mix thoroughly, slightly vexed, in medicine pot, moderate heat is fried to color burn, and tack-free is degree, takes out to dry in the air cool, smashs to pieces for subsequent use; Semen Euryales, Fructus Viticis and Semen Sesami Nigrum are placed in pulverizer pulverize, for subsequent use;
(3) step (2) raw materials treated medicine and Radix Angelicae Sinensis, Caulis et Folium fici Tikouae, Folium Nelumbinis, Omphalia, Poria cum Radix Pini, Radix Marsdeniae Longipedis and Fructus Lycii are together placed in frying pan, adding distil water, slow fire boiling twice, first time decocts 1-3 hour (preferably first time decocts 2 hours), second time decocts 40-80 minute (preferably second time decocts 60 minutes), filter, merge twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (1) gained mixing fine powders, continue to decoct 15-35 minute (preferably continuing decoction 25 minutes), filter, obtain filtrate; Gained filtrate being heated to 50 DEG C of relative densities is the concentrated solution of 1.13-1.15;
(5) in above-mentioned concentrated solution, add ethanol mixing, leave standstill 15-20 hour (preferably leaving standstill 18 hours), filter, waste, reclaim ethanol, add distilled water, make medicinal liquid density be 1.08(25 DEG C), add correctives and Mel, stir evenly, fill, to obtain final product.
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence, preferred scheme is, leaves standstill 5-8 hour (preferred standing 6-7 hour, what be more preferably leaves standstill 6.5 hours) in step (1).
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence, preferred scheme is, the middle 90-150 mesh sieve excessively of step (1) (preferred 110-130 mesh sieve excessively, mistake 120 mesh sieve be more preferably).
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence, preferred scheme is, the distilled water (preferably adding the distilled water of 9-11 times of material quantity, the distilled water adding 10 times of material quantities be more preferably) of 7-13 times of material quantity is added in step (3).
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence, preferred scheme is, in step (5), the mass concentration of added ethanol is the concentration of the preferred added ethanol of 60%-100%(is 70%-90%, and the mass concentration of the added ethanol be more preferably is 80%).
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence, preferred scheme is, the 40%-50% of the amount of ethanol to be the amount of the preferred ethanol of 30%-60%(of concentrated liquid measure be concentrated liquid measure in step (5), the amount of the ethanol be more preferably is 45% of concentrated liquid measure).
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence, preferred scheme is, step (5) herb liquid: correctives: Mel=4:1.1:0.9.
Scientific formula of the present invention, preparation method is simple, taking convenience, Be very effective.In addition, excellent results of the present invention also shows:
1 ,traditional property of medicine and Chinese medicine modern pharmacology organically combine by the present invention, using drugs to form a prescription, promote curative effect;
2 ,this Chinese medicine has invigorating the liver and kidney, benefiting QI for activating blood circulation, effect of nourishing the brain and improving intelligence, can significantly improve the level of intelligence of disturbance of intelligence patient, and safety has no side effect;
3 ,medicine source of the present invention is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1contribute to the medicament improving disturbance of intelligence patient level of intelligence, be prepared from by following bulk drugs, be weight portion (40g/ part): Semen Euryales 10 parts; 15 parts, Folium Nelumbinis; Rhizoma Polypodiodis Nipponicae 15 parts; Ramulus Cinnamomi 15 parts; Omphalia 9 parts; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 8 parts; Semen Sesami Nigrum 20 parts; Radix Angelicae Sinensis 15 parts; Poria cum Radix Pini 15 parts; Haematitum 3 parts; Caulis et Folium fici Tikouae 5 parts; Radix Marsdeniae Longipedis 8 parts; Fructus Viticis 8 parts; Fructus Lycii 15 parts; Fructus Alpiniae Oxyphyllae 15 parts.
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence is:
(1) Ramulus Cinnamomi adds clear water and is dipped to epidermis deliquescing, and removing epidermis, cleans, section, and put in smokeless stove fire, heating is dried, and have black speck to surperficial buff, taking-up cools, and grinds for subsequent use; Rhizoma Polypodiodis Nipponicae and Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. are cleaned, and join in the salt grain made popular, and it is buff slightly focal spot that slow fire heating continues to stir-fry to medical material surface, takes out, lets cool, grind for subsequent use; Haematitum is placed in the fine grinding of white beeswax water, outwells water layer, three times repeatedly, to water layer redfree, leaves standstill 5 hours, filtered through gauze, dry, continues to grind to form fine powder, for subsequent use; By gained fine powder, mixing, crosses 90 mesh sieves, loads in penetrating bag, for subsequent use;
(2) get refined honey to add water and make old honey, join in the Fructus Alpiniae Oxyphyllae of clean system, mix thoroughly, slightly vexed, in medicine pot, moderate heat is fried to color burn, and tack-free is degree, takes out to dry in the air cool, smashs to pieces for subsequent use; Semen Euryales, Fructus Viticis and Semen Sesami Nigrum are placed in pulverizer pulverize, for subsequent use;
(3) step (2) raw materials treated medicine and Radix Angelicae Sinensis, Caulis et Folium fici Tikouae, Folium Nelumbinis, Omphalia, Poria cum Radix Pini, Radix Marsdeniae Longipedis and Fructus Lycii are together placed in frying pan, add the distilled water of 7 times of material quantities, slow fire boiling twice, first time decocts 1 hour, second time decocts 40 minutes, filters, merges twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (1) gained mixing fine powders, continue decoction 15 minutes, filter, obtain filtrate; Gained filtrate being heated to 50 DEG C of relative densities is the concentrated solution of 1.13-1.15;
(5) mass concentration adding 30% concentrated liquid measure in above-mentioned concentrated solution is the ethanol mixing of 60%, leave standstill 15 hours, filter, waste, reclaim ethanol, add distilled water, medicinal liquid density is made to be 1.08(25 DEG C), add correctives and Mel (medicinal liquid: correctives: Mel=4:1.1:0.9), stir evenly, fill, to obtain final product.
The instructions of taking of oral liquid of the present invention is: each 20-30mL, every day three times, 20 days courses for the treatment of.
embodiment 2contribute to the medicament improving disturbance of intelligence patient level of intelligence, be prepared from by following bulk drugs, be weight portion (20g/ part): Semen Euryales 20 parts; 30 parts, Folium Nelumbinis; Rhizoma Polypodiodis Nipponicae 20 parts; Ramulus Cinnamomi 30 parts; Omphalia 15 parts; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 16 parts; Semen Sesami Nigrum 30 parts; Radix Angelicae Sinensis 20 parts; Poria cum Radix Pini 30 parts; Haematitum 6 parts; Caulis et Folium fici Tikouae 9 parts; Radix Marsdeniae Longipedis 12 parts; Fructus Viticis 12 parts; Fructus Lycii 30 parts; Fructus Alpiniae Oxyphyllae 30 parts.
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence is:
(1) Ramulus Cinnamomi adds clear water and is dipped to epidermis deliquescing, and removing epidermis, cleans, section, and put in smokeless stove fire, heating is dried, and have black speck to surperficial buff, taking-up cools, and grinds for subsequent use; Rhizoma Polypodiodis Nipponicae and Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. are cleaned, and join in the salt grain made popular, and it is buff slightly focal spot that slow fire heating continues to stir-fry to medical material surface, takes out, lets cool, grind for subsequent use; Haematitum is placed in the fine grinding of white beeswax water, outwells water layer, three times repeatedly, to water layer redfree, leaves standstill 8 hours, filtered through gauze, dry, continues to grind to form fine powder, for subsequent use; By gained fine powder, mixing, crosses 150 mesh sieves, loads in penetrating bag, for subsequent use;
(2) get refined honey to add water and make old honey, join in the Fructus Alpiniae Oxyphyllae of clean system, mix thoroughly, slightly vexed, in medicine pot, moderate heat is fried to color burn, and tack-free is degree, takes out to dry in the air cool, smashs to pieces for subsequent use; Semen Euryales, Fructus Viticis and Semen Sesami Nigrum are placed in pulverizer pulverize, for subsequent use;
(3) step (2) raw materials treated medicine and Radix Angelicae Sinensis, Caulis et Folium fici Tikouae, Folium Nelumbinis, Omphalia, Poria cum Radix Pini, Radix Marsdeniae Longipedis and Fructus Lycii are together placed in frying pan, add the distilled water of 13 times of material quantities, slow fire boiling twice, first time decocts 3 hours, second time decocts 80 minutes, filters, merges twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (1) gained mixing fine powders, continue decoction 35 minutes, filter, obtain filtrate; Gained filtrate being heated to 50 DEG C of relative densities is the concentrated solution of 1.13-1.15;
(5) mass concentration adding 60% concentrated liquid measure in above-mentioned concentrated solution is the ethanol mixing of 100%, leave standstill 20 hours, filter, waste, reclaim ethanol, add distilled water, medicinal liquid density is made to be 1.08(25 DEG C), add correctives and Mel (medicinal liquid: correctives: Mel=4:1.1:0.9), stir evenly, fill, to obtain final product.
The instructions of taking of oral liquid of the present invention is: each 20-30mL, every day three times, 20 days courses for the treatment of.
Model case: Cui XX, man, 9 years old, people from Tengzhou.Patient is to our hospital on July 15th, 2013.Its female Dai Shu: all normally, do not have obvious physiological defect to infant when birth, later along with slowly increasing, find that child child more of the same age grows comparatively slow, also not sociable by two years old, action behavior is accessible at ordinary times, is sparing of one's words, and learning capacity is poor.Check: brain in patients is grown normal, routine blood test is normal, and without strange behavior, dull expression, reticent hypologia, emaciated physique, tongue body slight of stature, pale tongue, tongue are greasy in vain, and soft pulse is sliding.Be diagnosed as disturbance of intelligence.
Take the oral liquid that the present embodiment gained contributes to improving disturbance of intelligence patient level of intelligence, instructions of taking: each 20-30mL, every day three times, 20 days courses for the treatment of.Take after two months, patient's personality is optimistic, active gradually, visual cognitive ability, strong to nouveaut curiosity, likes imitating surroundings; Continue to take two months, patients symptomatic obviously alleviates, and exhorts father and mother's multihoming child, and temper and cultivate child and support oneself, many and child links up, and adheres to medication, follows up a case by regular visits to after half a year, and all are normal, in the pink of condition for infant.
embodiment 3contribute to the medicament improving disturbance of intelligence patient level of intelligence, be prepared from by following bulk drugs, be weight portion (35g/ part): Semen Euryales 14 parts; 20 parts, Folium Nelumbinis; Rhizoma Polypodiodis Nipponicae 17 parts; Ramulus Cinnamomi 20 parts; Omphalia 10 parts; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10 parts; Semen Sesami Nigrum 23 parts; Radix Angelicae Sinensis 17 parts; Poria cum Radix Pini 20 parts; Haematitum 4 parts; Caulis et Folium fici Tikouae 6 parts; Radix Marsdeniae Longipedis 9 parts; Fructus Viticis 9 parts; Fructus Lycii 20 parts; Fructus Alpiniae Oxyphyllae 20 parts.
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence is:
(1) Ramulus Cinnamomi adds clear water and is dipped to epidermis deliquescing, and removing epidermis, cleans, section, and put in smokeless stove fire, heating is dried, and have black speck to surperficial buff, taking-up cools, and grinds for subsequent use; Rhizoma Polypodiodis Nipponicae and Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. are cleaned, and join in the salt grain made popular, and it is buff slightly focal spot that slow fire heating continues to stir-fry to medical material surface, takes out, lets cool, grind for subsequent use; Haematitum is placed in the fine grinding of white beeswax water, outwells water layer, three times repeatedly, to water layer redfree, leaves standstill 6 hours, filtered through gauze, dry, continues to grind to form fine powder, for subsequent use; By gained fine powder, mixing, crosses 110 mesh sieves, loads in penetrating bag, for subsequent use;
(2) get refined honey to add water and make old honey, join in the Fructus Alpiniae Oxyphyllae of clean system, mix thoroughly, slightly vexed, in medicine pot, moderate heat is fried to color burn, and tack-free is degree, takes out to dry in the air cool, smashs to pieces for subsequent use; Semen Euryales, Fructus Viticis and Semen Sesami Nigrum are placed in pulverizer pulverize, for subsequent use;
(3) step (2) raw materials treated medicine and Radix Angelicae Sinensis, Caulis et Folium fici Tikouae, Folium Nelumbinis, Omphalia, Poria cum Radix Pini, Radix Marsdeniae Longipedis and Fructus Lycii are together placed in frying pan, add the distilled water of 9 times of material quantities, slow fire boiling twice, first time decocts 1.5 hours, second time decocts 50 minutes, filters, merges twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (1) gained mixing fine powders, continue decoction 20 minutes, filter, obtain filtrate; Gained filtrate being heated to 50 DEG C of relative densities is the concentrated solution of 1.13-1.15;
(5) mass concentration adding 40% concentrated liquid measure in above-mentioned concentrated solution is the ethanol mixing of 70%, leave standstill 16 hours, filter, waste, reclaim ethanol, add distilled water, medicinal liquid density is made to be 1.08(25 DEG C), add correctives and Mel (medicinal liquid: correctives: Mel=4:1.1:0.9), stir evenly, fill, to obtain final product.
The instructions of taking of oral liquid of the present invention is: each 20-30mL, every day three times, 20 days courses for the treatment of.
embodiment 4contribute to the medicament improving disturbance of intelligence patient level of intelligence, be prepared from by following bulk drugs, be weight portion (25g/ part): Semen Euryales 16 parts; 25 parts, Folium Nelumbinis; Rhizoma Polypodiodis Nipponicae 18 parts; Ramulus Cinnamomi 25 parts; Omphalia 13 parts; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 14 parts; Semen Sesami Nigrum 27 parts; Radix Angelicae Sinensis 18 parts; Poria cum Radix Pini 25 parts; Haematitum 5 parts; Caulis et Folium fici Tikouae 8 parts; Radix Marsdeniae Longipedis 11 parts; Fructus Viticis 11 parts; Fructus Lycii 25 parts; Fructus Alpiniae Oxyphyllae 25 parts.
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence is:
(1) Ramulus Cinnamomi adds clear water and is dipped to epidermis deliquescing, and removing epidermis, cleans, section, and put in smokeless stove fire, heating is dried, and have black speck to surperficial buff, taking-up cools, and grinds for subsequent use; Rhizoma Polypodiodis Nipponicae and Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. are cleaned, and join in the salt grain made popular, and it is buff slightly focal spot that slow fire heating continues to stir-fry to medical material surface, takes out, lets cool, grind for subsequent use; Haematitum is placed in the fine grinding of white beeswax water, outwells water layer, three times repeatedly, to water layer redfree, leaves standstill 7 hours, filtered through gauze, dry, continues to grind to form fine powder, for subsequent use; By gained fine powder, mixing, crosses 130 mesh sieves, loads in penetrating bag, for subsequent use;
(2) get refined honey to add water and make old honey, join in the Fructus Alpiniae Oxyphyllae of clean system, mix thoroughly, slightly vexed, in medicine pot, moderate heat is fried to color burn, and tack-free is degree, takes out to dry in the air cool, smashs to pieces for subsequent use; Semen Euryales, Fructus Viticis and Semen Sesami Nigrum are placed in pulverizer pulverize, for subsequent use;
(3) step (2) raw materials treated medicine and Radix Angelicae Sinensis, Caulis et Folium fici Tikouae, Folium Nelumbinis, Omphalia, Poria cum Radix Pini, Radix Marsdeniae Longipedis and Fructus Lycii are together placed in frying pan, add the distilled water of 11 times of material quantities, slow fire boiling twice, first time decocts 2.5 hours, second time decocts 70 minutes, filters, merges twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (1) gained mixing fine powders, continue decoction 30 minutes, filter, obtain filtrate; Gained filtrate being heated to 50 DEG C of relative densities is the concentrated solution of 1.13-1.15;
(5) mass concentration adding 50% concentrated liquid measure in above-mentioned concentrated solution is the ethanol mixing of 90%, leave standstill 19 hours, filter, waste, reclaim ethanol, add distilled water, medicinal liquid density is made to be 1.08(25 DEG C), add correctives and Mel (medicinal liquid: correctives: Mel=4:1.1:0.9), stir evenly, fill, to obtain final product.
The instructions of taking of oral liquid of the present invention is: each 20-30mL, every day three times, 20 days courses for the treatment of.
Model case: Xiao XX, female, 13 years old, patient was to our hospital on May 10th, 2013.Its female Dai Shu: when patient is born, stages of labor is longer, causes anoxia asphyxia, impaired development, growth promoter than age cohorts a little later.Infant is talkative at ordinary times, and behavior is how dynamic, strange, absent minded, and self care ability is poor, can only complete the simple computation within 10.Check: patient's thinking is abnormal, nature and flavor are eccentric, IQ at 40-50, dark tongue quality, thready and hesitant pulse.Be diagnosed as disturbance of intelligence.
Take the oral liquid that the present embodiment gained contributes to improving disturbance of intelligence patient level of intelligence, instructions of taking: each 20-30mL, every day three times, 20 days courses for the treatment of.Take after two months, patient's emotion is stablized gradually, other symptoms are obviously improved, continue two courses for the treatment of of medication, patient clinical transference cure, visual cognitive ability, learning capacity improves, exhort that continuing medication is consolidated two courses for the treatment of, advise that father and mother add to guide child, its self-care ability of cultivation and training simultaneously.
embodiment 5contribute to the medicament improving disturbance of intelligence patient level of intelligence, be prepared from by following bulk drugs, be weight portion (30g/ part): Semen Euryales 15 parts; 22.5 parts, Folium Nelumbinis; Rhizoma Polypodiodis Nipponicae 17.5 parts; Ramulus Cinnamomi 22.5 parts; Omphalia 11.5 parts; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 12 parts; Semen Sesami Nigrum 25 parts; Radix Angelicae Sinensis 17.5 parts; Poria cum Radix Pini 22.5 parts; Haematitum 4.5 parts; Caulis et Folium fici Tikouae 7 parts; Radix Marsdeniae Longipedis 10 parts; Fructus Viticis 10 parts; Fructus Lycii 22.5 parts; Fructus Alpiniae Oxyphyllae 22.5 parts.
The above-mentioned preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence is:
(1) Ramulus Cinnamomi adds clear water and is dipped to epidermis deliquescing, and removing epidermis, cleans, section, and put in smokeless stove fire, heating is dried, and have black speck to surperficial buff, taking-up cools, and grinds for subsequent use; Rhizoma Polypodiodis Nipponicae and Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. are cleaned, and join in the salt grain made popular, and it is buff slightly focal spot that slow fire heating continues to stir-fry to medical material surface, takes out, lets cool, grind for subsequent use; Haematitum is placed in the fine grinding of white beeswax water, outwells water layer, three times repeatedly, to water layer redfree, leaves standstill 6.5 hours, filtered through gauze, dry, continues to grind to form fine powder, for subsequent use; By gained fine powder, mixing, crosses 120 mesh sieves, loads in penetrating bag, for subsequent use;
(2) get refined honey to add water and make old honey, join in the Fructus Alpiniae Oxyphyllae of clean system, mix thoroughly, slightly vexed, in medicine pot, moderate heat is fried to color burn, and tack-free is degree, takes out to dry in the air cool, smashs to pieces for subsequent use; Semen Euryales, Fructus Viticis and Semen Sesami Nigrum are placed in pulverizer pulverize, for subsequent use;
(3) step (2) raw materials treated medicine and Radix Angelicae Sinensis, Caulis et Folium fici Tikouae, Folium Nelumbinis, Omphalia, Poria cum Radix Pini, Radix Marsdeniae Longipedis and Fructus Lycii are together placed in frying pan, add the distilled water of 10 times of material quantities, slow fire boiling twice, first time decocts 2 hours, second time decocts 60 minutes, filters, merges twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (1) gained mixing fine powders, continue decoction 25 minutes, filter, obtain filtrate; Gained filtrate being heated to 50 DEG C of relative densities is the concentrated solution of 1.13-1.15;
(5) mass concentration adding 45% concentrated liquid measure in above-mentioned concentrated solution is the ethanol mixing of 80%, leave standstill 18 hours, filter, waste, reclaim ethanol, add distilled water, medicinal liquid density is made to be 1.08(25 DEG C), add correctives and Mel (medicinal liquid: correctives: Mel=4:1.1:0.9), stir evenly, fill, to obtain final product.
The instructions of taking of oral liquid of the present invention is: each 20-30mL, every day three times, 20 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Euryales: base is former: be the mature seed kernel of nymphaeaceae plant Gorgon euryale.Chemical analysis: seed is containing volume starch.Containing 4.4 grams, protein in every 100 grams, 0.2 gram, fat, carbohydrate 32 grams, crude fibre 0.4 gram, ash 0.5 gram, calcium 9 milligrams, 110 milligrams, phosphorus, ferrum 0.4 milligram, thiamine 0.40 milligram, 0.08 milligram, riboflavin, nicotinic acid 2.5 milligrams, 6 milligrams, ascorbic acid, carotene trace.Nature and flavor: sweet puckery are flat.Gui Jing: enter spleen, kidney channel.Function cures mainly: reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak.Control seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, loose stool and diarrhea.
Folium Nelumbinis: base is former: this product is the dried leaves of nymphaeaceae plant lotus.Chemical analysis: leaf is containing nuciferine, nuciferine, miltanthin, armepavine, pronuciferine (+)-Pronuciferine, N-demethyl nuciferine, D-N-methyl coclaurine, anonaine, liriodendrin, Quercetin, Isoquercitrin, lotus glycoside, tartaric acid, citric acid, malic acid, gluconic acid, oxalic acid, succinic acid, tannin.Also containing the alkaline components of resisting mitosis effect.Nature and flavor: bitter are flat.Gui Jing: return liver, spleen, stomach warp.Effect: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.Cure mainly: for multiple hemorrhage and puerperal blood faints.
Rhizoma Polypodiodis Nipponicae: base is former: be the rhizome of Plants of Polypodiaceae Rhizoma Polypodiodis Nipponicae.Nature and flavor: bitter, cool.Function cures mainly: removing dampness, and heat clearing away is dispeled the wind, dredging collateral, controls that acute diseases such as cholera and sunstroke is dirty has loose bowels, dysentery, gonorrhea nebulousurine, migratory arthralgia, lumbago, acute catarrhal conjunctivitis, and skin ulcer swells.
Ramulus Cinnamomi: base is former: this product is the dry twig of canella Cortex Cinnamomi.Nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Pharmacological action: 1, antibacterial action, 2, antivirus action, 3, diuresis.
Omphalia: base is former: be the sclerotium of Polyporaceae plant Omphalia lapidescens.Chemical analysis: moisture content 6.5%, ash 4.0%, ether extractum 0.6%, alcohol extract 22%.Nature and flavor: bitter, cold, slightly poisonous.Gui Jing: enter stomach, large intestine channel.Function cures mainly: removing food stagnancy, parasite killing.Control abdominal pain due to worm stagnation, infantile malnutrition, acute infantile convulsion.
Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh.: base is former: the orchid family Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh., is used as medicine with stem.Nature and flavor: sweet, light are flat.Function cures mainly: replenishing YIN and removing heat.Cure mainly consumption of body fluid caused by febrile disease, lips and teeth are dry, hectic fever, night sweat, arthritis.
Semen Sesami Nigrum: base is former: be the seed of Pedaliaceae plant sesame.Chemical analysis: fatty oil is the glyceride such as oleic acid, linoleic acid, Palmic acid, stearic acid, arachidic acid, and containing sesamin, sesamolin, sesamol, linum glycoside, planteose, sesame seed candy etc.Nature and flavor: property is put down, sweet in the mouth.Function cures mainly: invigorating the liver and kidney, benefiting essence-blood, and intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.
Radix Angelicae Sinensis: base is former: this product is the dry root of umbelliferae angelica.Chemical analysis: root is containing volatile oil, and Minxian County, Gansu product person contains 0.7% containing 0.4%, Si Chuanwen county product person.Volatilization main body of oil has: butylidenephthalide, the positive pentanone of adjacent carboxyl benzene and Δ 2,4-dihydro acid phthalic anhydride.Nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Cure mainly: for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Poria cum Radix Pini: base is former: be the natural white portion entertaining Radix Pini massonianae (i.e. " Lignum Poria ") in the middle of Polyporaceae plant poria cocos sclerotium.Nature and flavor: sweet light are flat.Gui Jing: enter the heart, spleen channel.Function cures mainly: mind calming, calms the nerves, diuretic.Control palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.Pharmacological action: sedation.
Haematitum: base is former: be the Ore of oxide-based mineral bloodstone.Chemical analysis: main containing iron sesquioxide, wherein ferrum 70%, oxygen 30%, sometimes impure titanium, magnesium, aluminum, silicon and moisture.Nature and flavor: bitter, sweet, flat.Gui Jing: return liver, stomach, heart born of the same parents warp.Function cures mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.
Caulis et Folium fici Tikouae: base is former: be stem, the leaf of moraceae plants Radix Pachyrhizi Erosi.Nature and flavor: bitter, cold.Function cures mainly: heat clearing away, and dampness removing is invigorated blood circulation, removing toxic substances.Control cough due to pathogenic wind-heat, dysentery, edema, jaundice, rheumatalgia, bleeding hemorrhoids, amenorrhea, leukorrhagia, infantile dyspepsia, traumatic injury, innominate toxic swelling.
Radix Marsdeniae Longipedis: base is former: be the Herb of asclepiadaceae plant Radix Marsdeniae Longipedis.Nature and flavor: sweet micro-hardship, temperature, poisonous.Gui Jing: liver; Kidney channel.Function cures mainly: expelling wind and removing dampness; Relieving asthma; Promoting blood circulation to remove obstruction in the collateral.Main air pain of dampness syndrome; Rheumatic heart disease; Bronchial asthma; Traumatic injury damages appoints; Fracture.
Fructus Viticis: base is former: this product is the dry mature fruit of Verbenaceae Vitex rotundifolia or wild pepper.Character: this product is spherical in shape, diameter 4-6mm.Surface grey black or pitchy, by canescence Refined Mercurous chloride shape fine hair, have longitudinal shallow ridges 4, top nick, base portion has canescence Constellation calyx and short carpopodium.Nature and flavor: pungent, bitter, are slightly cold.Gui Jing: return bladder, liver, stomach warp.Effect: dispelling wind and heat pathogens, the clear sharp head.Cure mainly: for anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.
Fructus Lycii: base is former: be the mature fruit of matrimony vine of solanaceae plant or lycium barbarum.Chemical analysis: containing carotene 3.39 milligrams of %, thiamine 0.23 milligram of %, riboflavin 0.33 milligram of %, nicotinic acid 1.7 milligrams of %, ascorbic acid 3 milligrams of % in Fructus Lycii.Still isolate cupreol, linoleic acid.Pharmacological action: 1. lipotropic effect; 2. choline-like effect is intended; Nature and flavor: sweet are flat.Gui Jing: enter liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Fructus Alpiniae Oxyphyllae: base is former: be the fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.Nature and flavor: pungent, temperature.Gui Jing: enter spleen, kidney channel.Function cures mainly: warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.
test example 1gained of the present invention contributes to the clinical practice of the medicament (embodiment 5) improving disturbance of intelligence patient level of intelligence:
1 data and method
1.1 physical data
Choose the patient being diagnosed as disturbance of intelligence that in April, 2011, my institute of in December ,-2013 accepted for medical treatment totally 186 examples, wherein male 106 example, women 80 example, the age 6-16 year, 10.5 years old mean age.Its mild or moderate disturbance of intelligence 113 example, moderate disturbance of intelligence 57 example, severe disturbance of intelligence 13 example, pole severe disturbance of intelligence 3 example.
1.2 screening criteria
(1) all patients all carry out Haskell Wexler test of intelligence, and intelligent quotient be less than 70 points regard as disturbance of intelligence.Its mild or moderate person IQ is 50-69, and moderate person's IQ is 35-49, and severe person's IQ is 20-34, and pole severe person's IQ is below 20
(2) the differential diagnosis of diseases standard of traditional Chinese medical science disturbance of intelligence (mental retardation) is met.
1.3 Therapeutic Method
All patients are divided into treatment group and matched group at random, and two groups of patients, in sex, the state of an illness, the course of disease etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein treatment group takes gained medicine of the present invention, and matched group takes other medicine (as mental treasure ball, Fructus Alpiniae Oxyphyllae health brain ball, piracetam granule conventional medication).Treat four courses for the treatment of altogether.
1.4 curative effect determinate standard
Clinical cure: sings and symptoms all disappears, level of intelligence significantly improves; Effective: sings and symptoms partial disappearance or obviously alleviate, level of intelligence significantly improves; Effective: sings and symptoms takes a turn for the better to some extent, level of intelligence slightly improves; Invalid: symptom is unchanged, level of intelligence is without improvement.
1.5 therapeutic outcome
Result is as shown in table 1.
Table 1: the therapeutic outcome for the treatment of group and matched group patient
Therapeutic effect: cure 53 examples (55.2%), effective 32 examples (33.3%), effective 9 examples (9.4%), invalid 2 examples (2.1%), total effective rate 97.9%.Treatment group successful is better than matched group.
Take period intelligence and change of spirit as shown in table 2.
Table 2: take period two groups of patient's intelligence and change of spirit
The present invention is prepared from by 15 taste primary raw material medicines such as Semen Euryales, Folium Nelumbinis, Rhizoma Polypodiodis Nipponicae, Ramulus Cinnamomi, Omphalia, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh., Semen Sesami Nigrum, Radix Angelicae Sinensis, Poria cum Radix Pini, Haematitum, Caulis et Folium fici Tikouae, Radix Marsdeniae Longipedis and Fructus Alpiniae Oxyphyllae.Fang Zhong, Semen Euryales reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak; Folium Nelumbinis clearing away summer-heat, sending up the lucid YANG; Rhizoma Polypodiodis Nipponicae has heat clearing away, dispels the wind, effect of dredging collateral, refreshment; Poria cum Radix Pini has the effect of mind tranquilizing and the heart calming; Radix Marsdeniae Longipedis expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Fructus Alpiniae Oxyphyllae enters spleen, kidney channel, warming the spleen, warming the kidney, solid and gas, arresting seminal emission; Full side's compatibility, plays the merit of promoting blood circulation to remove obstruction in the collateral, nourishing the brain and improving intelligence altogether.Treat four courses for the treatment of, treatment group total effective rate is 97.9%, and matched group total effective rate is only 76.7%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. contribute to the medicament improving disturbance of intelligence patient level of intelligence, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Euryales 10-20; Folium Nelumbinis 15-30; Rhizoma Polypodiodis Nipponicae 15-20; Ramulus Cinnamomi 15-30; Omphalia 9-15; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 8-16; Semen Sesami Nigrum 20-30; Radix Angelicae Sinensis 15-20; Poria cum Radix Pini 15-30; Haematitum 3-6; Caulis et Folium fici Tikouae 5-9; Radix Marsdeniae Longipedis 8-12; Fructus Viticis 8-12; Fructus Lycii 15-30; Fructus Alpiniae Oxyphyllae 15-30.
2. contribute to the medicament improving disturbance of intelligence patient level of intelligence as claimed in claim 1, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Euryales 14-16; Folium Nelumbinis 20-25; Rhizoma Polypodiodis Nipponicae 17-18; Ramulus Cinnamomi 20-25; Omphalia 10-13; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10-14; Semen Sesami Nigrum 23-27; Radix Angelicae Sinensis 17-18; Poria cum Radix Pini 20-25; Haematitum 4-5; Caulis et Folium fici Tikouae 6-8; Radix Marsdeniae Longipedis 9-11; Fructus Viticis 9-11; Fructus Lycii 20-25; Fructus Alpiniae Oxyphyllae 20-25.
3. contribute to the medicament improving disturbance of intelligence patient level of intelligence as claimed in claim 1, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Semen Euryales 15; Folium Nelumbinis 22.5; Rhizoma Polypodiodis Nipponicae 17.5; Ramulus Cinnamomi 22.5; Omphalia 11.5; Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 12; Semen Sesami Nigrum 25; Radix Angelicae Sinensis 17.5; Poria cum Radix Pini 22.5; Haematitum 4.5; Caulis et Folium fici Tikouae 7; Radix Marsdeniae Longipedis 10; Fructus Viticis 10; Fructus Lycii 22.5; Fructus Alpiniae Oxyphyllae 22.5.
4. the preparation method contributing to the oral liquid of raising disturbance of intelligence patient level of intelligence as described in claim 1-3, it is characterized in that, step is as follows:
(1) Ramulus Cinnamomi adds clear water and is dipped to epidermis deliquescing, and removing epidermis, cleans, section, and put in smokeless stove fire, heating is dried, and have black speck to surperficial buff, taking-up cools, and grinds for subsequent use; Rhizoma Polypodiodis Nipponicae and Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. are cleaned, and join in the salt grain made popular, and it is buff slightly focal spot that slow fire heating continues to stir-fry to medical material surface, takes out, lets cool, grind for subsequent use; Haematitum is placed in the fine grinding of white beeswax water, outwells water layer, three times repeatedly, to water layer redfree, leaves standstill, filtered through gauze, dry, continues to grind to form fine powder, for subsequent use; By gained fine powder, mixing, sieves, loads in penetrating bag, for subsequent use;
(2) get refined honey to add water and make old honey, join in the Fructus Alpiniae Oxyphyllae of clean system, mix thoroughly, slightly vexed, in medicine pot, moderate heat is fried to color burn, and tack-free is degree, takes out to dry in the air cool, smashs to pieces for subsequent use; Semen Euryales, Fructus Viticis and Semen Sesami Nigrum are placed in pulverizer pulverize, for subsequent use;
(3) step (2) raw materials treated medicine and Radix Angelicae Sinensis, Caulis et Folium fici Tikouae, Folium Nelumbinis, Omphalia, Poria cum Radix Pini, Radix Marsdeniae Longipedis and Fructus Lycii are together placed in frying pan, adding distil water, slow fire boiling twice, first time decocts 1-3 hour (preferably first time decocts 2 hours), second time decocts 40-80 minute (preferably second time decocts 60 minutes), filter, merge twice decocting liquid;
(4) in above-mentioned decocting liquid, add step (1) gained mixing fine powders, continue to decoct 15-35 minute (preferably continuing decoction 25 minutes), filter, obtain filtrate; Gained filtrate being heated to 50 DEG C of relative densities is the concentrated solution of 1.13-1.15;
(5) in above-mentioned concentrated solution, add ethanol mixing, leave standstill 15-20 hour (preferably leaving standstill 18 hours), filter, waste, reclaim ethanol, add distilled water, make medicinal liquid density be 1.08(25 DEG C), add correctives and Mel, stir evenly, fill, to obtain final product.
5. the preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence according to claim 4, is characterized in that: leave standstill 5-8 hour in step (1) (preferred standing 6-7 hour, what be more preferably leaves standstill 6.5 hours).
6. the preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence according to claim 4, is characterized in that: the middle 90-150 mesh sieve excessively of step (1) (preferred 110-130 mesh sieve excessively, mistake 120 mesh sieve be more preferably).
7. the preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence according to claim 4, it is characterized in that: the distilled water (preferably adding the distilled water of 9-11 times of material quantity, the distilled water adding 10 times of material quantities be more preferably) adding 7-13 times of material quantity in step (3).
8. the preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence according to claim 4, it is characterized in that: in step (5), the mass concentration of added ethanol is the concentration of the preferred added ethanol of 60%-100%(is 70%-90%, and the mass concentration of the added ethanol be more preferably is 80%).
9. the preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence according to claim 4, it is characterized in that: the 40%-50% of the amount of ethanol to be the amount of the preferred ethanol of 30%-60%(of concentrated liquid measure be concentrated liquid measure in step (5), the amount of the ethanol be more preferably is 45% of concentrated liquid measure).
10. the preparation method contributing to the oral liquid improving disturbance of intelligence patient level of intelligence according to claim 4, is characterized in that: step (5) herb liquid: correctives: Mel=4:1.1:0.9.
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