CN104529896B - 一种二芳基取代异喹啉化合物的合成方法 - Google Patents
一种二芳基取代异喹啉化合物的合成方法 Download PDFInfo
- Publication number
- CN104529896B CN104529896B CN201410757773.4A CN201410757773A CN104529896B CN 104529896 B CN104529896 B CN 104529896B CN 201410757773 A CN201410757773 A CN 201410757773A CN 104529896 B CN104529896 B CN 104529896B
- Authority
- CN
- China
- Prior art keywords
- compound
- synthetic method
- formula
- reaction
- palladium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC1([C@@]2C=C3C([Al]C)=NC(*)=C(*)C3=CC12)N Chemical compound CC1([C@@]2C=C3C([Al]C)=NC(*)=C(*)C3=CC12)N 0.000 description 4
- ROFVEXUMMXZLPA-UHFFFAOYSA-N c1ccnc(-c2ccccn2)c1 Chemical compound c1ccnc(-c2ccccn2)c1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410757773.4A CN104529896B (zh) | 2014-12-11 | 2014-12-11 | 一种二芳基取代异喹啉化合物的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410757773.4A CN104529896B (zh) | 2014-12-11 | 2014-12-11 | 一种二芳基取代异喹啉化合物的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104529896A CN104529896A (zh) | 2015-04-22 |
CN104529896B true CN104529896B (zh) | 2017-05-03 |
Family
ID=52845576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410757773.4A Active CN104529896B (zh) | 2014-12-11 | 2014-12-11 | 一种二芳基取代异喹啉化合物的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104529896B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106674050B (zh) * | 2016-12-15 | 2018-05-11 | 温州大学 | 一种二苯甲酮取代异喹啉化合物的合成方法 |
CN106674106A (zh) * | 2016-12-15 | 2017-05-17 | 温州医科大学附属第二医院 | 一种拓扑异构酶i抑制剂的合成方法 |
CN106674109A (zh) * | 2016-12-15 | 2017-05-17 | 温州医科大学附属第二医院 | 一种抗癌抑制剂中间体的合成方法 |
CN106632039A (zh) * | 2016-12-15 | 2017-05-10 | 温州医科大学附属第二医院 | 一种抗肿瘤含氮杂环药物中间体的合成方法 |
CN106674107A (zh) * | 2016-12-15 | 2017-05-17 | 温州医科大学附属第二医院 | 一种抗肿瘤药物化合物的合成方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4786443A (en) * | 1987-03-11 | 1988-11-22 | Shell Oil Company | Process for the carbonylation of olefinically unsaturated compounds with a palladium catalyst |
CN101429165A (zh) * | 2007-11-09 | 2009-05-13 | 温州大学 | 一种喹唑啉酮类化合物的合成方法 |
CN102503883A (zh) * | 2011-10-18 | 2012-06-20 | 上海交通大学 | 选择性制备异吲哚啉-1-酮衍生物或异喹啉-1-酮衍生物的方法 |
WO2012093271A1 (en) * | 2010-12-16 | 2012-07-12 | H4Sep Kft | A new palladium catalyst, method for its preparation and its use |
CN103288730A (zh) * | 2012-02-27 | 2013-09-11 | 海洋王照明科技股份有限公司 | 含喹啉有机半导体材料、其制备方法及有机电致发光器件 |
CN103435558A (zh) * | 2013-09-02 | 2013-12-11 | 温州大学 | 一种喹唑啉衍生物的合成方法 |
-
2014
- 2014-12-11 CN CN201410757773.4A patent/CN104529896B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4786443A (en) * | 1987-03-11 | 1988-11-22 | Shell Oil Company | Process for the carbonylation of olefinically unsaturated compounds with a palladium catalyst |
CN101429165A (zh) * | 2007-11-09 | 2009-05-13 | 温州大学 | 一种喹唑啉酮类化合物的合成方法 |
WO2012093271A1 (en) * | 2010-12-16 | 2012-07-12 | H4Sep Kft | A new palladium catalyst, method for its preparation and its use |
CN102503883A (zh) * | 2011-10-18 | 2012-06-20 | 上海交通大学 | 选择性制备异吲哚啉-1-酮衍生物或异喹啉-1-酮衍生物的方法 |
CN103288730A (zh) * | 2012-02-27 | 2013-09-11 | 海洋王照明科技股份有限公司 | 含喹啉有机半导体材料、其制备方法及有机电致发光器件 |
CN103435558A (zh) * | 2013-09-02 | 2013-12-11 | 温州大学 | 一种喹唑啉衍生物的合成方法 |
Non-Patent Citations (4)
Title |
---|
A Novel Synthesis of 1-Substituted 2H-Isoquinolin-3-ones;Alicia S. Cánepa,等;《Journal of Heterocyclic Chemistry》;20041231;第41卷(第6期);第979-982页 * |
An expedient synthesis of poly-substituted 1-arylisoquinolines from δ-ketonitriles via indium-mediated Barbier reaction protocol;Sung Hwan Kim,等;《Tetrahedron Letters》;20090906;第50卷(第47期);第6476-6479页 * |
Convenient Synthesis of N-Substituted 1-Alkyl and 1-Aryl-3-Aminoisoquinolines;Alicia S. Cánepa,等;《Journal of Heterocyclic Chemistry》;20060228;第43卷(第1期);第235-238页 * |
钯-稀土催化一氧化碳和苯乙烯交替共聚反应;郭锦棠,等;《催化学报》;20040331;第25卷(第03期);第231-237页 * |
Also Published As
Publication number | Publication date |
---|---|
CN104529896A (zh) | 2015-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104529896B (zh) | 一种二芳基取代异喹啉化合物的合成方法 | |
CN104529895B (zh) | 一种取代含氮杂环化合物的合成方法 | |
CN104610250A (zh) | 含三个氮杂环的1,2,3-噻二唑-5-甲脒类化合物及合成 | |
CN101020658B (zh) | 喹诺酮主环化合物的合成方法 | |
CN112679420B (zh) | 一种2,5-二溴吡啶的制备方法 | |
CN105218621B (zh) | 一类具有抗肿瘤活性的脱氢枞酸苯并咪唑席夫碱类杂环衍生物及其制备方法和应用 | |
Dunwell et al. | Synthesis and antiinflammatory activity of some 2-heteroaryl-. alpha.-methyl-5-benzoxazoleacetic acids | |
CN105566215A (zh) | 一种瑞戈非尼的制备方法 | |
CN103755628B (zh) | 2-氨基-3-碘-5-溴吡啶的合成方法 | |
CN104557701B (zh) | 一种异喹啉衍生物的制备方法 | |
CN104725325B (zh) | 一种2‑(1‑苯乙基)喹唑啉酮及其催化合成方法 | |
CN106083539B (zh) | 一种单氟甲氧基或单氟氘代甲氧基类化合物的合成方法 | |
TWI829641B (zh) | 嘧啶酮類化合物的製備方法 | |
CN108558758A (zh) | 一种4-氟异喹啉-5-胺的合成方法 | |
CN109384767A (zh) | 一种吡啶并嘧啶类衍生物的制备方法及其中间体 | |
CN111533706B (zh) | 一种1,4,6-三取代1,2-二氢-三嗪类化合物的制备方法 | |
CN105272921A (zh) | 一种制备Ceritinib的方法及其中间体化合物 | |
CN113861103A (zh) | 一种合成吡啶、联吡啶、三联吡啶配体的方法 | |
CN103896889B (zh) | 拉帕替尼中间体及其制备方法和应用 | |
CN105367481A (zh) | 一种3,3-二氟-2-氧化吲哚衍生物的合成方法 | |
CN105399683B (zh) | 苯并咪唑衍生物及其制备方法 | |
CN101434601B (zh) | 一种2-呋喃基-1h-苯并咪唑-4-酰胺型衍生物 | |
CN106432105B (zh) | 一种迈华替尼的化学合成方法 | |
CN104761506B (zh) | 一种2‑(1‑苯乙烯基)喹唑啉酮化合物及其合成方法 | |
CN109734713A (zh) | 一种3-亚胺基咪唑并[1,2-a]吡啶化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Chen Jiuxi Inventor after: Wu Huayue Inventor after: Liu Miaochang Inventor after: Ding Jinchang Inventor after: Gao Wenxia Inventor after: Huang Xiaobo Inventor before: Wu Huayue Inventor before: Chen Jiuxi Inventor before: Liu Miaochang Inventor before: Ding Jinchang Inventor before: Gao Wenxia Inventor before: Huang Xiaobo |
|
CB03 | Change of inventor or designer information | ||
GR01 | Patent grant | ||
GR01 | Patent grant |