CN104528772A - Innocent treatment method for producing solid wastes by using metformin hydrochloride - Google Patents
Innocent treatment method for producing solid wastes by using metformin hydrochloride Download PDFInfo
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- CN104528772A CN104528772A CN201410814401.0A CN201410814401A CN104528772A CN 104528772 A CN104528772 A CN 104528772A CN 201410814401 A CN201410814401 A CN 201410814401A CN 104528772 A CN104528772 A CN 104528772A
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- solid waste
- walaphage
- innocent treatment
- carbonate
- solid wastes
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Abstract
The invention belongs to the technical field of chemical engineering and in particular relates to an innocent treatment method for producing solid wastes by using metformin hydrochloride. Alkali liquor is added into the solid wastes, organic matters are converted into recyclable carbonate and ammonia gas by virtue of a high-pressure reaction, the ammonia nitrogen value and COD in the treated wastewater are low, and the ammonia nitrogen and COD can be continuously recycled and also can be emitted by virtue of simple biochemical treatment. The atom utilization ratio is high, secondary pollution is avoided, the ammonia water and carbonate can be recycled, high-concentration waste alkali liquid can be used, and the method has obvious economic benefits and social benefits.
Description
Technical field
The invention belongs to chemical technology field, be specifically related to a kind of method for innocent treatment of Walaphage production solid waste.
Background technology
Walaphage is one oral hypoglycaemic medicine safely and effectively, for the world today being also Chinese adult type ii diabetes people oral prescription antidiabetic drug with the most use.The demand of present Walaphage and turnout still have sizable scale.Walaphage is obtained by dimethylamine hydrochloride and dicyandiamide condensation, can be divided into primary isoamyl alcohol method, DMF method according to the difference of solvent in condensation course.The highest yield of these two kinds of methods is all no more than 90%, also just means and still has a large amount of by products, if these by products can not obtain rationally process will cause very large pollution to environment.
In prior art, Walaphage mother liquor produces a large amount of solid waste after having reclaimed solvent, and its complicated component mostly is itrogenous organic substance and nitrogen content is high, and separation cannot be relied on to obtain any valuable material.If these by products enter water body or soil will bring severe contamination, so must it be processed.Treatment process at present about nitrogenous solid waste mostly is biochemical treatment process, but for the solid waste mentioned in this programme, because its ammonia nitrogen value is high, carbon-nitrogen ratio is low, complex operation step can be caused according to this rule and processing efficiency is low, therefore simple biochemical treatment process is not suitable for this programme needs the processing scheme developing a kind of effective environmental protection badly.
Summary of the invention
The present invention is directed to above-mentioned problems of the prior art, harmless treatment has been carried out to the solid waste produced in Walaphage production process, through reaction under high pressure, organism to be converted into carbonate and the ammonia of recoverable by adding alkali lye in solid waste, ammonia nitrogen in waste water value after process and COD all lower, both can return cover continuously and also can discharge after simple biochemical treatment.
Indication solid waste complicated component of the present invention but mostly wherein be itrogenous organic substance as Dyhard RU 100 (C
2h
4n
4), biguanides (C
2h
7n
5), N, N-dimethylguanidine (C
3h
9n
3), N, N-dimethyl trimeric cyanamide (C
5h
10n
6) etc., can there is cracking through high temperature, high pressure in these organism, finally become carbonate, ammonia G&W, this method atom utilization is high can not produce secondary pollution under highly basic exists.
The alkali that the present invention adds is sodium hydroxide, potassium hydroxide, sodium carbonate, salt of wormwood, high-concentration waste sodium hydroxide solution or potassium hydroxide solution; Alkali add-on at least should be 1.5 times of solid waste weight; Temperature of reaction must not lower than 200 DEG C; Reaction times must not lower than 5 hours.
Advantage of the present invention is: first, and the treatment process atom utilization that this programme relates to is high, does not produce secondary pollution, also recyclable ammoniacal liquor and carbonate; Secondly, this programme is less demanding to used alkali, and both also can use with new alkali the high concentration waste alkali solution produced in other Chemical Manufacture, the solid waste so both having processed Walaphage also consumes salkali waste, this method is killed two birds with one stone, and has obvious economic benefit and social benefit.
Embodiment
Embodiment 1: add 100g solid waste, 400g water (Walaphage Workshop Production waste water) in 1000ml autoclave, slowly add 200g sodium hydroxide under stirring, reinforced complete, tighten autoclave, be slowly warming up to 230 DEG C of insulations 10 hours.React complete, be cooled to about 95 DEG C.Pressure relief opening connected a conduit and be inserted into bottom in the 500ml there-necked flask filling 200ml purified water, slowly opening pressure relief opening and reclaim ammoniacal liquor, reclaiming ammoniacal liquor 228g(concentration 12.3% altogether).Reclaim complete, feed liquid proceeded in another 1000ml four-hole boiling flask and add 1g gac and reflux 0.5 hour, suction filtration while hot, mother liquor is steamed and separates out white sodium carbonate solid except being cooled to 0-10 DEG C after 100ml water, after oven dry 125g, be 98.5% through titration detection level.
Embodiment 2: add 100g solid waste, 400g water (Walaphage Workshop Production waste water) in 1000ml autoclave, slowly add 150g sodium hydroxide under stirring, reinforced complete, tighten autoclave, be slowly warming up to 210 DEG C of insulations 10 hours.React complete, be cooled to about 95 DEG C.Pressure relief opening connected a conduit and be inserted into bottom in the 500ml there-necked flask filling 200ml purified water, slowly opening pressure relief opening and reclaim ammoniacal liquor, reclaiming ammoniacal liquor 218.2g(concentration 8.3% altogether).Reclaim complete, feed liquid proceeded in another 1000ml four-hole boiling flask and add 1g gac and reflux 0.5 hour, suction filtration while hot, mother liquor is steamed and separates out white sodium carbonate solid except being cooled to 0-10 DEG C after 100ml water, after oven dry 116g, be 98.6% through titration detection level.
Embodiment 3: criticize mother liquor add 100g solid waste, 400g in 1000ml autoclave before, slowly add 200g sodium hydroxide under stirring, reinforced complete, tighten autoclave, be slowly warming up to 230 DEG C of insulations 10 hours.React complete, be cooled to about 95 DEG C.Pressure relief opening connected a conduit and be inserted into bottom in the 500ml there-necked flask filling 200ml purified water, slowly opening pressure relief opening and reclaim ammoniacal liquor, reclaiming ammoniacal liquor 232g(concentration 13.8% altogether).Reclaim complete, feed liquid proceeded in another 1000ml four-hole boiling flask and add 1g gac and reflux 0.5 hour, suction filtration while hot, mother liquor is steamed and separates out white sodium carbonate solid except being cooled to 0-10 DEG C after 100ml water, after oven dry 130g, be 98.5% through titration detection level.
Embodiment 4: add 100g solid waste in 1000ml autoclave, 600g 40% waste lye (sulfamethoxazole produces waste liquid, containing a small amount of sodium carbonate substantially without organism) tightens autoclave, be slowly warming up to 230 DEG C of insulations 10 hours.React complete, be cooled to about 95 DEG C.Pressure relief opening connected a conduit and be inserted into bottom in the 500ml there-necked flask filling 200ml purified water, slowly opening pressure relief opening and reclaim ammoniacal liquor, reclaiming ammoniacal liquor 225g(concentration 11.1% altogether).Reclaim complete, feed liquid is proceeded in another 1000ml four-hole boiling flask and add 2.5g gac and reflux 0.5 hour, suction filtration while hot, mother liquor is steamed and separates out off-white color sodium carbonate solid except being cooled to 0-10 DEG C after 150ml water, obtaining 130g after oven dry, is 97.6% through titration detection level.
Claims (6)
1. a method for innocent treatment for Walaphage production solid waste, is characterized in that: by adding alkali lye in solid waste, through reaction under high pressure, organism is converted into carbonate and the ammonia of recoverable.
2. the method for innocent treatment of Walaphage production solid waste as claimed in claim 1, is characterized in that: solid waste complicated component, but mostly wherein is itrogenous organic substance as Dyhard RU 100 (C
2h
4n
4), biguanides (C
2h
7n
5), N, N-dimethylguanidine (C
3h
9n
3), N, N-dimethyl trimeric cyanamide (C
5h
10n
6) etc.
3. the method for innocent treatment of Walaphage production solid waste as claimed in claim 2, is characterized in that: the alkali added is sodium hydroxide, potassium hydroxide, sodium carbonate, salt of wormwood, high-concentration waste sodium hydroxide solution or potassium hydroxide solution.
4. the method for innocent treatment of Walaphage production solid waste as claimed in claim 3, is characterized in that: alkali add-on at least should be 1.5 times of solid waste weight.
5. the method for innocent treatment of Walaphage production solid waste as claimed in claim 4, is characterized in that: temperature of reaction must not lower than 200 DEG C.
6. the method for innocent treatment of Walaphage production solid waste as claimed in claim 5, is characterized in that: the reaction times must not lower than 5 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410814401.0A CN104528772A (en) | 2014-12-25 | 2014-12-25 | Innocent treatment method for producing solid wastes by using metformin hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410814401.0A CN104528772A (en) | 2014-12-25 | 2014-12-25 | Innocent treatment method for producing solid wastes by using metformin hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104528772A true CN104528772A (en) | 2015-04-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410814401.0A Pending CN104528772A (en) | 2014-12-25 | 2014-12-25 | Innocent treatment method for producing solid wastes by using metformin hydrochloride |
Country Status (1)
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| CN (1) | CN104528772A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107056719A (en) * | 2017-06-03 | 2017-08-18 | 寿光富康制药有限公司 | It is a kind of that the method that solid waste is recycled is produced to Metformin hydrochloride |
| CN113943068A (en) * | 2021-11-30 | 2022-01-18 | 江苏同禾药业有限公司 | Treatment method of metformin hydrochloride production wastewater |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119250A (en) * | 2014-07-15 | 2014-10-29 | 徐晓宁 | Production method of high-purity metformin hydrochloride |
-
2014
- 2014-12-25 CN CN201410814401.0A patent/CN104528772A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119250A (en) * | 2014-07-15 | 2014-10-29 | 徐晓宁 | Production method of high-purity metformin hydrochloride |
Non-Patent Citations (4)
| Title |
|---|
| 王丽娟等: "反相离子对HPLC法同时测定盐酸二甲双胍中双氰胺和三聚氰胺的含量", 《烟台大学学报（自然科学与工程版）》 * |
| 王宝品等: "三聚氰酸的降解方法", 《中国高新技术企业》 * |
| 程宗佳等: "《来自饲料生产第一线的技术问答》", 30 April 2013, 中国农业科学技术出版社 * |
| 翁玲玲主编: "《临床药物化学》", 31 August 2007, 人民卫生出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107056719A (en) * | 2017-06-03 | 2017-08-18 | 寿光富康制药有限公司 | It is a kind of that the method that solid waste is recycled is produced to Metformin hydrochloride |
| CN107056719B (en) * | 2017-06-03 | 2020-04-24 | 寿光富康制药有限公司 | Method for recycling solid waste produced in metformin hydrochloride production |
| CN113943068A (en) * | 2021-11-30 | 2022-01-18 | 江苏同禾药业有限公司 | Treatment method of metformin hydrochloride production wastewater |
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Application publication date: 20150422 |
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| RJ01 | Rejection of invention patent application after publication |