CN104524422B

CN104524422B - A kind of pill that treating gynecomastia and preparation method

Info

Publication number: CN104524422B
Application number: CN201410706426.9A
Authority: CN
Inventors: 李毅; 牛兆霞; 杨美荣; 朱雪洁
Original assignee: Qingdao Women and Childrens Hospital
Current assignee: Qingdao Women and Childrens Hospital
Priority date: 2014-11-28
Filing date: 2014-11-28
Publication date: 2019-05-31
Anticipated expiration: 2034-11-28
Also published as: CN104524422A

Abstract

The invention discloses a kind of pill for treating gynecomastia and preparation methods, belong to the field of Chinese medicines.The raw material of effective ingredient of the present invention forms are as follows: Cortex Eucommiae, teasel root, Semen Cuscutae, Rhizoma Atractylodis Macrocephalae, HERBA EPIMEDII, fructus lycii, cortex cinnamomi, radix bupleuri, rhizoma cyperi, dried orange peel, Radix Salviae Miltiorrhizae, Poria cocos, cortex moutan, Rhizoma Chuanxiong, radix paeoniae rubra, the fleece-flower root, curcuma zedoary, pilose antler, radix cyathulae, rhizoma alismatis, rhizoma pinellinae praeparata, tuber fleeceflower stem, bulbus fritillariae cirrhosae, Radix Glycyrrhizae, pulp of dogwood fruit, thizoma curculiginis, said medicine is processed with ad hoc approach, is prepared as pellet product.The present invention selects medicinal material to meet a monarch and his subjects left side and is allowed to manage, pharmacological property is mutually fitted mutually auxiliary, for liver kidney dystrophy, qi and blood is unsmooth, liver energy depression and phlegm stagnation, and the causes of disease such as qi depression to blood stasis are suited the remedy to the case, nourishing liver and kidney, liver soothing and depression relief, promoting blood circulation and removing obstruction in channels, good absorption effect, it is significant in efficacy, it has no toxic side effect and clinical adverse, it is higher to gynecomastia cure rate according to clinical verification.

Description

A kind of pill that treating gynecomastia and preparation method

Technical field

The present invention relates to the field of Chinese medicines more particularly to a kind of pill for treating gynecomastia and preparation methods.

Background technique

Gynecomastia is common clinical disease, refers to that man's breast is unilateral or double after puberty or adult Side breast increases, and occurs oblate lump under mammary areola, even gynecoid type breast is presented, with the illness of distending pain.Clinic is also known as male Property mammary hypertrophy.It after this disease can betide puberty and adult, but is more with middle age and the aged.With hebetic year Age shifts to an earlier date, and clinic also sees 10 years old or so child patient.This disease belongs to benign mammary gland interstitial and catheter hyperplasia, and has voluntarily The case of recession.

Modern medicine thinks that the pathogenic factor of this disease is not affirmed still, it is considered that related with endocrine disorder.Testicualr development Bad or testis inflammation, damage, tumour can lead to 3male hormone secretion reduction.And the exception of liver function, and can lead to female Obstacle occurs for the inactivation of hormone, can both make intracorporal estrogen level is opposite to increase, so as to cause breast tissue development and Paraplasm.In addition, taken for a long time because of hypertrophy of the prostate and prostate cancer estrin treatment and prolonged application digitalis, The drugs such as Reserpine, isoniazid, isonizaone can cause male breast proliferation loose.

There are the drug therapy and operative treatment of adjustment estrogen and androgen level on western medical treatment at present.Operation is generally under local anaesthesia It carries out, general operation has through areola edge, nipple, mammary areola transverse incision and on the outside of mammary areola and breast makees L shape notch, by mammary gland Tissue and partial skin excision.Postoperative drainage, pressure dressing take antibiotic prophylaxis infection in 7 days；Heptan also can be used in addition to operation The treatment of the hormone medicines such as alkanoic acid protona, tamoxifen, Clomifene, testosterone lactone.But abnormal pigmentary deposit on the skin trace is easily stayed for surgical removal, Not only it had influenced beautiful but also easy to recur.It is more at present not use, it removes because breast is excessive, distending pain is obvious, or even causes the upper anxiety of patient mental It is uneasy；And long-term steroid adjust class drug therapy, can not short-term response, need Long-term Hormone drug, this can be to patient There is very big side effect, therefore doctor trained in Western medicine is unsatisfactory to the treatment method of gynecomastia.

Chinese medicine thinks that man's breast category kidney, nipple category liver, if feelings will is uncomfortable, the violent rage impariment of the liver causes stagnation of liver qi unsmooth, strongly fragrant Long then change fire, the body fluid for liver kidney of burning, hepatic disorder, function of detoxification is low, and the female hormone for keeping human body excessive is from liver It is dirty to be inactivated, and act on target organ breast or aged debility, chronic disease involving kidney, caused by liver and kidney deficiency, kidney it is yin-yang deficiency, cannot Edema with the liver involved is conserved, wood gas does not relax, and catharsis dereliction of duty, then phlegm wet stops gathering, this disease or congenital pathogen impairing the liver can also occur for the newborn network of upper knot, and liver is lost Catharsis all can lead to channels and collaterals dystrophy, and qi and blood is unsmooth, to blood stasis and phlegm stagnation occur, obstruction of meridian forms gynecomastia.Always It, disease disease position is dialectical to be related to liver,spleen,kidney in breast；Characteristic of disease simulataneous insufficiency and excessive；The leading interpretation of the cause, onset and process of an illness is liver energy depression and phlegm stagnation, qi depression to blood stasis； Also soothing the liver resolving sputum, the promoting flow of qi and blood circulation is treated, is helped with resolving hard lump, kidney tonifying, essence replenishing etc.；It is added and subtracted when clinical with disease.The male of Chinese traditional treatment at present Property Gynecomastia it is less at side, mostly with dispersing stagnated hepatoqi, based on clearing and activating the channels and collaterals, there is certain curative effect, but treatment cycle Longer slow effect.

Pill of the present invention mostly uses adjusting and reinforcing liver and kidney, to adjust function of the hypothalamus --- hypophysis --- between testis axis, Restore liver function simultaneously, reinforce the deactivation to superfluous estrogen, boost metabolism, improves qi-blood circulating, reach liver protection Kidney-nourishing rationally adjusts endocrine, and hormone in vivo level is made to keep relative equilibrium, for treating gynecomastia, from old complaint It sets out, treating both manifestation and root cause of disease, the side effect of no doctor trained in Western medicine hormone medicine, curative effect is also very significant.

Summary of the invention

The present invention provides a kind of pill for treating gynecomastia and preparation methods, have nourishing liver and kidney, liver of relaxing The effect of relieve stagnation, reducing phlegm and resolving masses, cures the disease and seeks source treating both manifestation and root cause of disease, all has very well to gynecomastia caused by a variety of causes Curative effect.

To achieve the above object, technical solution of the present invention is implemented as follows:

The raw material composition and parts by weight of the effective ingredient is made in a kind of pill for treating gynecomastia Are as follows:

The raw material composition and parts by weight of the effective ingredient is made are as follows:

A kind of preparation method of pill that treating gynecomastia, comprises the following steps that:

(1) by fructus lycii, pulp of dogwood fruit, cortex cinnamomi, Poria cocos, cortex moutan, radix bupleuri, dried orange peel, radix cyathulae, rhizoma pinellinae praeparata, tuber fleeceflower stem, sweet Grass is uniformly mixed after cleaning, drying, and is put into container, the water of 6~8 times of amounts is added in a reservoir, heating is boiled 3~4 hours, cold But immersion liquid is taken afterwards；The water of 4~6 times of amounts is added in the remaining dregs of a decoction, heating is boiled 2~3 hours, immersion liquid after cooling；Merge Gained immersion liquid twice, heating are concentrated by evaporation as the thick paste of relative density 1.10~1.20, spare；

(2) fleece-flower root, teasel root, Semen Cuscutae are put into container, the shao-hsing rice wine of 3~5 times of amounts are added, is cooled after boiling, Continue immersion 3~4 hours, takes immersion liquid；The shao-hsing rice wine that 2~3 times of amounts are added in the remaining dregs of a decoction, puts after boiling and dries in the air, after It is continuous to impregnate 2~3 hours, take immersion liquid；Merge gained immersion liquid twice, adds and be concentrated by evaporation as the thick of relative density 1.15~1.25 Cream, it is spare；

(3) it is ground after crushing pilose antler, curcuma zedoary, bulbus fritillariae cirrhosae, crosses 120 mesh dusting covers, obtain fine powder, it is spare；

(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, radix paeoniae rubra, thizoma curculiginis are put into iron pan, the micro- stir-fry of mild fire, are fried to epidermis after turning yellow, sprinkling Jimo is old Wine, continue fry to epidermis it is sallow after, taking-up cools, and crushing is ground, cross 120 mesh dusting covers, obtain fine powder, it is spare；

(5) rhizoma cyperi is taken to clean slice, the rice vinegar for the amount of reordering is mixed thoroughly, after bored profit is sucked to vinegar, is set in frying container, with text Fire heating fried dry, taking-up cool down.Clast is weeded out, crushing is ground, and is crossed 120 mesh dusting covers, is obtained fine powder, spare；

(6) it takes quantitative common salt to be dissolved in clear water, uniformly admixes in Eucommia ulmoides, set heating in pot and stir-fry to dry, medicinal material Surface color slightly depth is degree, weeds out clast, and crushing is ground, and crosses 120 mesh dusting covers, obtains fine powder, spare；

(7) it takes suet to enter heating fusing in pot, adds HERBA EPIMEDII and mix stir-frying thoroughly to suet exhaustion, medicinal material is crisp, weeds out Clast, crushing are ground, and are crossed 120 mesh dusting covers, are obtained fine powder, spare；

(8) it taking Radix Salviae Miltiorrhizae, rhizoma alismatis to clean slice and dry, Radix Salviae Miltiorrhizae, rhizoma alismatis piece is added, stir-frying sprays even, fried dry for several times, with yellow rice wine, Crushing is ground, and is crossed 120 mesh dusting covers, is obtained fine powder, spare；

It (9) will be by step (1), step (2) resulting thick paste, with step (3), step (4), step (5), step (6), step Suddenly (7), the mixing of fine powder obtained in step (8), are added refined honey after mixing evenly, are prepared as the pill of every 10g.

The property of medicine of Chinese medicine is as follows:

Cortex Eucommiae: sweet in flavor；Micro-pungent；It is warm-natured.Enter liver；Kidney channel.Nourishing liver and kidney；Strengthening the bones and muscles.Cure mainly spinal column ache；Rheumatic arthralgia.It is " standby Anxious Qianjin Yao Fang " it carries: " wind-damp dispelling, stopping numbness pain, liver and kidney benefiting fill blood, and be affected by the cold damp evil, and waist and knee crymodynia, podomere is bent and stretched not Benefit, or paralysis are meciless, chilly happiness temperature." modern medical studies have confirmed that Cortex Eucommiae has sedation to nerve center, cell can be enhanced Immune function, promote cortisol secretion and cAMP in plasma and cGMP metabolism.

Teasel root: bitter；It is pungent；Slightly warm in nature.Return liver；Kidney channel.Nourishing liver and kidney；Strengthening the bones and muscles；Adjust blood vessels；Continuous injured；Only metrorrhagia and metrostaxis.For Back ache；Podomere flaccidity syndrome and arthralgia syndrome；Fall and flutters wound；It damages disk and rolls over bone；Ulcer sore swells." Standards of Diagnosis and Treatment " carry: " sweet temperature is supporing yang, pungent to dissipate the stasis of blood, It has concurrently and tonifies the liver and kidney, strong bone strengthening, promoting blood circulation function." modern medical studies have confirmed that teasel root contains, there are many alkaloids and micro Element titanium plays the role of antivitamin E deficiency disease, plays the role of apocenosis to large carbuncle, hemostasis, analgesia, promotes regeneration.

Semen Cuscutae: acrid flavour；It is sweet；It is mild-natured.Enter liver；Kidney；The spleen channel.Tonifying kidney and benefiting sperm；It nourishes the liver to improve visual acuity；Gu tire stopping leak.Cure mainly waist and knee Ache；Spermatorrhea；Impotence；Premature ejaculation；Infertility；It quenches one's thirst；Stranguria with turbid discharge；The enuresis；Blurred vision tinnitus；Threatened abortion；Miscarriage；Diarrhea." book on Chinese herbal medicine converges Speech " carry: " tonifying kidney and nourishing liver, warm spleen help the medicine of stomach, but mend without high, and warm but not dry, void can mend, in fact can benefit, trembling with fear can be with Temperature, heat can be cool, and temperature can be dry, dry to moisten." modern medical studies have confirmed that Semen Cuscutae can significantly protect hepatic injury active, Increase nonspecific resistance, enhances Sexual potency, in addition there are antitumor, anti-inflammatory, antisterility, lead to diarrhea and inhibit central nervous system The effect of system.

Rhizoma Atractylodis Macrocephalae: bitter；It is sweet；It is warm-natured.Returns spleen；Stomach meridian.Strengthening the spleen and replenishing qi；Eliminate dampness and have diuretic effect；Hidroschesis；Miscarriage prevention.Cure mainly deficiency-weakness of spleen-QI； Spiritlessness and weakness；Deficiency of food abdominal distension；Big loose stool is thin；Fluid retention stagnating in the interior；Difficult urination；Oedema；Phlegmatic vertigo；Arthritis with fixed pain caused by dampness is ached；Spontaneous perspiration due to deficiency of vital energy； Threatened abortion." this is through meeting original " carries: " art, raw to control wind-cold-dampness arthralgia with there is dehumidifying dry, the dissolving phlegm Li Shui of benefit, dead flesh convulsion subcutaneous ulcer dissipates waist navel Between blood and chong channel be disease, the function of urgency in inverse gas；Make it is ripe, have with middle tonifying Qi, slake thirst and help produce saliva, hidroschesis is except warm, into diet, miscarriage prevention it Effect." modern medical studies have confirmed that Rhizoma Atractylodis Macrocephalae plays the role of strong and improves body resistance against diseases, enhance gulping down for reticuloendothelial system Function is bitten, the function of leukocytes phagocytic staphylococcus aureus is enhanced, has leukogenic effect to leukopenia, it is thin to improve lymph Dysuria with lower abdominal colic rate, promote cellular immune function, to staphylococcus aureus, hemolytic streptococcus, viridans streptococci, pneumococcus, Meningococcus, corynebacterium diphtheriae, hay bacillus have different degrees of inhibiting effect, to acrothesium floccosum, star-shaped nocardia, violet The dermatophytes such as color trichophyta, Trichophyton concentricum have certain inhibiting effect.

HERBA EPIMEDII: acrid flavour；It is sweet；It is warm-natured.Enter liver；Kidney two warp.Tonifying kidney and strengthening yang；Dispelling wind and eliminating dampness；Strengthening the muscles and bones.Cure mainly waist and knee acid It is soft；Rheumatic arthralgia；Hemiplegia；Four limbs are meciless." Bencao Jingshu " carries: " liver governing tendons, Shen controls bone, then muscles and bones is certainly hard for kidney-nourishing liver. It is pungent can dissipating bind, in Gan Nenghuan, temperature can ventilate promoting circulation of blood, therefore sore is arranged at the red carbuncle of main scrofula and lower part, washes out worm." modern medicine study card Real, HERBA EPIMEDII has more significant inhibiting effect to staphylococcus albus, staphylococcus aureus, to Nai Shi micrococcus catarrhalis, pneumonia Diplococcus, haemophilus influenzae have slight inhibiting effect, can be reduced red blood cell hematocrit, accelerate erythrocyte sedimentation rate, reduce whole blood contrast viscosity, mention High DNA synthetic ratio.

Fructus lycii: sweet in flavor；It is mild-natured.Return liver；Kidney；Lung channel.Nourishing the liver；Nourshing kidney；Moistening lung.Cure mainly caused by liver and kidney deficiency；It has a dizzy spell；Mesh It is clear depending on one；Soreness and weakness of waist and knees；The expensive essence of impotence；Cough due to consumptive disease；It quenches one's thirst and draws drink." book on Chinese herbal medicine is just " carries: " bright knowledge, adds the solid marrow of essence, and strong bone is strong Muscle is apt to mend internal lesion caused by overexertion, outstanding only to quench one's thirst." modern medical studies have confirmed that fructus lycii is adjusted body's immunity, can effectively inhibit swollen Tumor growth and cell mutation, with anti-aging, anti-fatty liver, the work for adjusting blood lipid and blood glucose, promotion hematopoiesis function etc. With.

Cortex cinnamomi: acrid flavour；It is bitter；Property heat.Enter kidney；Spleen；The heart；Liver Channel.Mends fire supporing yang；Let the fire back to its origin；Eliminating cold to stop pain；Wen Jingtong Arteries and veins.Cure mainly the insufficiency of the kidney yang；Gate of vitality's fire；Aversion to cold and cold limbs；Soreness and weakness of waist and knees；Impotence and seminal emission；Difficult urination or frequency；It loses heart syndrome characterized by dyspnea；It is floating The swollen all cards of oliguria；The Yang-function insufficiency of kidneyzang；Fiery not Gui Yuan；Floating yang；Refusing yang；And heat in the upper and cold in the lower；Flushing is cold enough；Dizziness and tinnitus；Dispute gruel is broken； Spleen kidney deficiency is cold；Coldness and pain in the epigastrium；Food subtracts loose stool；Lumbago due to the kidney deficiency；Numbness and ache of cold dampness；Cold hernia pain；Uterus cold infertile；Dysmenorrhea menostasis；Postpartum Stasis of blood；Negative subcutaneous ulcer streamer；Or cold of insufficiency type large carbuncle purulence is not at bursting；Or it is not held back after bursting." haigoushen " carry: " cure mainly nine kinds it is pained, kill three Worm, main blood-breaking, the tonneau moon close, and control weak foot, numbness, meciless, placenta retension, except cough is inverse, knot gas gathers around numbness, and only cold air in abdomen, bitterly can not Bear, main diarrhea, nasal polyp.Herbicide wood poison." modern medical studies have confirmed that cortex cinnamomi contains cinnamic acid, cinnamyl acetate, acetic acid benzene The ingredients such as the third junket of base, have the function of fragrant stomach invigorating, antipyretic-antalgic, antibacterial anti-inflammatory.

Radix bupleuri: bitter；It is pungent；Cold nature.Return liver；Gallbladder channel.Inducing diaphoresis is brought down a fever；Soothing liver-qi stagnation, lifting disease.The major functions: exogenous disease is sent out Heat；Fevers and chills alternate；Malaria；Liver-depressed hypochondrium pain mammary swelling；Headache is dizzy；Irregular menstruation；The rectal prolapse of collapse from qi deficiency；Uterine prolapse；Under stomach It hangs down." detailed outline ", which carries, " to be controlled yang-energy to sink, calming the liver, gallbladder, three burnt, envelope phase fire, and headache, dizziness, blurred vision, red pain are hidden from view, deaf Ring, all malarias and fat gas fever and chills, married woman's invasion of blood chamber by heat, irregular menstruation, children's acne rash waste heat, the thin heat of five infantile malnutrition due to digestive disturbances or intestinalparasites." modern medicine study It confirms, radix bupleuri has antipyretic, calm, analgesia, antibechic, anti-inflammatory effect, while fighting hepatic lesion, cholagogue, anti-fatty liver, and promotes Enterocinesia etc. has certain effect.

Rhizoma cyperi: acrid flavour；Cold nature；It is nontoxic.Return liver；Lung；Spleen；Stomach；Tri-jiao channel.Regulating the flow of vital energy and dispeling melancholy；Menstruction regulating and pain relieving；Miscarriage prevention.It is main Control the distending pain in hypochondrium；Breast swelling；Hernia pain；Irregular menstruation；Epigastric abdominal fullness pain；Belch acid regurgitation；Evil of vomitting；Dysmenorrhea；It collapses Leak leukorrhagia；Threatened abortion." detailed outline " carries: " gas cold epidemic disease when dissipating, benefit three is burnt, Xie Nvyu, and the diet that disappears accumulation, phlegm retention feeling of fullness, instep is swollen, Abdominal distension, tinea pedis, only trusted subordinate, limbs, head, mesh, tooth, all pains of ear, ulcer sores are spitted blood, lower blood, hematuria, married woman's metrorrhagia and metrostaxis leukorrhagia, the moon Through uncomfortable, postpartum all kinds of diseases and ailments before tire." modern medicine study proves that rhizoma cyperi is adjustable nervous function, have heart tonifying, reducing heart rate, It reduces blood pressure, prevent and treat the effects of hyperlipemia and atherosclerosis.

Dried orange peel: acrid flavour；It is sweet；It is cold in nature.Enter spleen；Stomach meridian.Lower gas；In tune；Resolving sputum；It sobers up.Cure mainly feeding desorder；Upper gas is tired It is full；It gets sick from drinking too much wine thirsty." Japan hanako materia medica " carries: " soup is made in skin toast, can relieving alcoholism and wine it is thirsty, typhoid fever diet Lao Fuzhe, dense pan-fried juice clothes." Medicine clinical research shows that aurantiamarin contained by dried orange peel can inhibit gastric ulcer, reduces capillary permeability, has adjustment stomach Function and anti-inflammatory effect, volatile oil have the effects that eliminating the phlegm, relieving asthma, promote digestive juice secretion and exclude enteral pneumatosis, this It is outer there are also coronary artery dilator, reduce blood pressure and the effects of cholagogue.

Radix Salviae Miltiorrhizae: bitter；Cold nature；It is nontoxic.Enter the heart；Liver Channel.Promoting blood circulation for regulating menstruation；Stasis-dispelling and pain-killing；Cool blood to disappear carbuncle；Relieving restlessness and restlessness； Nourishing blood and tranquilization.Cure mainly trusted subordinate's perverse trend；Fever and chills accumulation；Ailment said due to cold or exposure stays heat.Shennong's Herbal carries: " main trusted subordinate's perverse trend, borborygmus is faint such as to leak water, Fever and chills accumulation；Broken disease removes lump in the abdomen, only dysphoria, QI invigorating." modern medical studies have confirmed that Radix Salviae Miltiorrhizae can improve plasmin activity, extend out Blood, clotting time inhibit platelet aggregation, expand coronary artery and peripheral blood vessel, increase myocardial blood flow, promote the reparation of tissue with Regeneration promotes the formation of fibroblast differentiation and collagenous fibres, inhibits the synthesis of intracellular originality cholesterol

Poria cocos: sweet in flavor；It is light；It is mild-natured.Enter the heart；Spleen；Lung；Kidney channel.Eliminating dampness and diuresis；Strengthening the spleen and stomach；Antitoxic heart-soothing and sedative.Cure mainly urine It is unfavorable；Edema swelling；Sip and cough；Vomiting；Spleen eating less；Let out wash with watercolours；Palpitation and restlessness；Insomnia forgetfulness；Spermatorrhea gonorrhoea." Bie Lu " It carries: " only quenching one's thirst, like to sleep, big abdomen, leaching drips, phlegm water in diaphragm, oedema leaching knot.Chest internal organs is opened, visceral-qi is adjusted, cuts down kidney heresy, long negative, benefiting energy, During guarantor's mind is kept." modern medical studies have confirmed that Poria cocos has inhibition to make staphylococcus aureus, Escherichia coli, proteus etc. With can kill the bacteriums such as Leptospira, there is certain protection to make digestive system, hematological system and central nervous system With furthermore pachyman content is very high, can anti-tumor activity.

Cortex moutan: acrid flavour is bitter；It is cool in nature, slightly cold, return heart；Liver；Kidney；Lung channel.Heat-clearing；Promoting blood circulation to remove blood stasis.The major functions: warm heat disease heat enters Blood system；Macular eruption；Hematemesis；Germ later period hot Fu Yin distribution heat brimful of tears；Deficiency of Yin osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhea；Carbuncle swells sore Poison；The pain of injury caused by falling and tumbling；Beriberoid pyretic arthralgia.Compendium of Material Medica: cortex moutan controls the few yin of brothers, yin four of fainting through blood system and lies prostrate fire.Gai Fuhuo is yin Fire, yin fire are phase fire, and ancient prescription only controls mutually fire with this, therefore Zhong Jing shenqi pill uses it.Descendant is specially controlling mutually fire with amur cork tree, is not known The function of the root bark of tree peony more wins.Red Hua Zheli, white flower person mend, and people also seldom realizes, and preferably distinguish it.

Rhizoma Chuanxiong: acrid flavour；It is warm-natured.Return liver；Gallbladder；Pericardium channel.Promoting blood circulation；Promote breath and open depression；Wind-expelling pain-stopping.Zhu Zhi wei lump in the abdomen is swollen Block；Pain in chest and hypochondrium；Headache and dizziness；Wind-cold-dampness arthralgia；Traumatic injury；Ulcer sores." book on Chinese herbal medicine is just " carries: " dispersing wind and cold controls pain, broken stasis of blood It stores, promoting blood circulation, unhitch gas, by pain, apocenosis detumescence, by blood promoting menstruation." modern medical science is the study found that Rhizoma Chuanxiong extracting solution pair Leukaemia cell is inhibited to have a certain effect, preparation has certain antibacterial action, especially to typhoid bacillus, paratyphosum Bacterium, suddenly Random vibrios, Pseudomonas aeruginosa and pathogenic dermatophyte etc. have inhibiting effect, and ligustrazine contained by Rhizoma Chuanxiong, ferulic acid are received to have and live Blood stagnation resolvation effect, expansible coronary artery promotes coronary flow, allevating angina pectoris, and has anti-thrombosis function, contained The effects of ligustilide has smooth muscle spasmolysis and inhibits myenteron, uterine contraction.

Radix paeoniae rubra: bitter；It is slightly cold.Return liver warp.Clearing heat and cooling blood；Removing blood stasis and acesodyne.Cure mainly febrile virulent maculae, hematemesis and epistaxis；Hot eyes is swollen Bitterly；Liver-depressed hypochondrium pain；Amenorrhea and algomenorrhea；Abdominal mass abdominal pain；Injury from falling down；Carbuncle swells sore.Shennong's Herbal carries: " bitter is flat, main perverse trend Abdominal pain, except blood-arthralgia, broken hard product fever and chills hernia lump in the abdomen, analgesic, raw Chuan Gu." modern medical studies have confirmed that radix paeoniae rubra to high viscid blood coronary heart disease Patient plays the role of changing hemorheological property, and can making whole blood viscosity, when erythrocyte electrophoretic time reduces, can be by influencing calcium generation Thank to antagonism atherosclerosis, water-alcohol extraction has significant sedation and analgesic effect, the acidity of gastric juice can be slightly improved, It can be used for improving appetite, digestive function and certain neuropathies.

The fleece-flower root: bitter；It is sweet；It is puckery；Slightly warm in nature.Return liver；Kidney channel.Nourishing the blood and yin；Relax bowel and defecation；Preventing malaria；Wind-dispelling；Removing toxic substances. The major functions: deficiency of blood Light-headedness；Palpitaition；Insomnia；The soreness and weakness of waist and knees of the deficiency of liver-yin and kidney-yin；Poliosis；Tinnitus；Spermatorrhea；Dry constipation of intestines；Long Malaria is physically weak；Rubella itch；Sore carbuncle；Scrofula.Compendium of Material Medica: the fleece-flower root, white person enter gas point, and red person enters blood system.Kidney master closes hiding, liver Main catharsis, this object temperature bitter and puckery flavor, bitter kidney tonifying, temperature compensation liver can restrain vital essence, so energy blood-nourishing benefit liver, controlling nocturnal emission with astringent drugs kidney-nourishing are good for muscle Bone, black hair are tonic medicine, and not cold not dry, function is on glutinous rehmannia, all medicines of lucid asparagus.Qi and blood Taihe county, then wind void, carbuncle swells, scrofula Known to all diseases (removing).

Curcuma zedoary: acrid flavour；It is bitter；It is warm-natured.Return liver；The spleen channel.Promoting the circulation of qi blood-breaking；Clearing stagnation and killing pain.It is pained to cure mainly vim and vigour；Eating accumulation； Abdominal distention；Amenorrhea due to stagnation of blood；Dysmenorrhea；Wei lump in the abdomen tumor lump in the abdomen；Traumatic injury." drugization justice " carries: " acrid flavour is strong, specializes in it in gas Blood, the main broken long-pending heavily fortified point that disappears, removes accumulation addiction block, menostasis blood stasis flutters report pain." modern medical studies have confirmed that curcuma zedoary to a variety of tumor strains Growth has apparent inhibition and destruction, has inhibiting effect to tumor, the metabolism of cancer cell core, significantly improves lymphocytes in blood Content, enhance oncocyte immunogenicity, temptation or promote body to the immunological rejection of tumour, improve radiotherapy effect Fruit.It takes decoction orally, grind or enters ball and is scattered；External application decoction is washed or is ground and dresses.Promoting qi circulation and relieving pain is mostly raw to be used, and dissipating blood stasis with potent drugs is preferably vinegar-fried.

Pilose antler: sweet in flavor；It is salty；It is warm-natured.Enter kidney；Liver Channel.Invigorating kidney yang；Benefiting essence-blood；Strengthening the bones and muscles；Torr sore poison.Cure mainly decline of kidney-YANG； Impotence involuntary emission；Uterus cold infertile；Consumptive disease is won thin；The tired chilly of mind；Dizziness；Hiccough and deaf；Aching pain in waist and back；Muscles and bones impotence；Children's five kinds of retardation； Woman's metrorrhagia and metrostaxis leukorrhagia；Negative subcutaneous ulcer." Bencao Jingshu " carries: " treating consumptive disease voluminous such as malaria, thin thin, painful limbs, pain along spinal column, small convenience to let out Essence, blood of drowning is broken to stay blood in abdomen, dissipates urolithiasis, carbuncle swells, and heat in bone, subcutaneous ulcer is itched." modern medical studies have confirmed that pilose antler ammonia rich in The cellular immunity and humoral immune function of body can be improved in base acid, lecithin, vitamin and microelement, promotes lymph thin The conversion of born of the same parents, has the function of immunopotentiating agent, moreover it is possible to increase body to extraneous defence capability, adjust intracorporal immunologic balance And disease is avoided to occur and promote wound healing, sick body rehabilitation.

Radix cyathulae: sweet in flavor；Slight bitter；It is mild-natured.Enter liver；Kidney channel.Promoting blood circulation；Expelling wind and removing dampness.Cure mainly blood stasis；Difficult labour； Placenta retension；Postpartum blood stasis abdominal pain；Heat gonorrhea；Urolithiasis；Dysmenorrhea；Rheumatism lumbocrural pain." Traditional Chinese Medicine in Sichuan will " carries: " expelling wind and removing dampness leads to Blood is dissipated, stranguria syndrome is controlled, hematuria is lost and drowns." modern medical studies have confirmed that insectean metamorphosis steroidal contained by radix cyathulae have it is stronger Protein synthesizes facilitation.

Rhizoma alismatis: sweet in flavor；It is light；It is cold in nature.Return kidney；Bladder meridian.Clearing damp and promoting diuresis；It expels the heat-evil treating stranguria.Cure mainly difficult urination；Heat gonorrhea is puckery Bitterly；Edema swelling；Diarrhea；Phlegmatic vertigo；Spermatorrhea." Bie Lu " carries: " qi-restoratives damages the exhaustion or lesion of the five internal organs, removes the five internal organs feeling of fullness, negative gas, stopping leak essence, It quenches one's thirst, drench drip, cut off the water by bladder, three cokes." modern medical studies have confirmed that rhizoma alismatis has reduction cholesterol and prevents Atherosclerosis Change effect, improves liver fat metabolism, reduces blood glucose, blood pressure, influences function of immune system, reduces serum hemolysin.

Rhizoma pinellinae praeparata: acrid flavour；It is warm-natured；It is slightly cold.Enter spleen；Stomach meridian.It is eliminating dampness and eliminating phlegm；Check drops；Dissolving lump and resolving mass；Outer subduing inflammation. " Bie Lu " carries: " subduing inflammation treats sallow, happy pool appearance." modern medical studies have confirmed that the tuber of pinellia has significant antitussive effect, energy The secretion for inhibiting body of gland, inhibits the hydrolysis of trypsase, in addition there are decompression, blood coagulation, promotes fissional effect.

Tuber fleeceflower stem: sweet in flavor；Slight bitter；It is mild-natured.Enter the heart；Liver Channel.Mental-tranquilization；Wind-dispelling；Dredging collateral.Cure mainly insomnia；Dreaminess；The deficiency of blood Bodily pain；Numbness；Rheumatic arthralgia；Rubella itch." medicine materical crude slice is newly joined " carries: " nourishing liver and kidney, only abnormal sweating, tranquilizing the mind hypnosis, bowl spares gas, It passes through network, internal lesion caused by overexertion is controlled in promoting blood circulation." modern medical studies have confirmed that tuber fleeceflower stem contains rheum emodin, Physcion, with amobarbital Sodium has significant calm, syngignoscism, especially extension slow wave sleep phase in synergistic effect.

Bulbus fritillariae cirrhosae: sweet in flavor；It is bitter；Cold nature.Return lung；The heart channel of Hang-Shaoyin.Clearing heat and moistening lung；Preventing phlegm from forming and stopping coughing；Mass dissipating and swelling eliminating.Cure mainly the deficiency syndrome of the lung； Chronic cough；Cough due to consumptive disease；Cough caused by dryness-heat；Pulmonary abscess；Scrofula；Carbuncle swells；Acute mastitis." collected statements on the herbal foundation ": fritillaria opens the medicine of strongly fragrant, lower gas, resolving sputum ?.Moistening lung dissolving phlegm, relieving cough and relieving asthma, then the card of consumptive disease fire knot, fritillaria specially take charge of first dose.Therefore match rhizoma anemarrhenae, it can be with clean air enriching yin；With a kind of reed mentioned in ancient books, It even can clear phlegm fall fire；It can go to mend with over sixty years of age ginseng and not gather；With return, Chinese herbaceous peony can be with regulating the qi flowing in the channels and battalion；Again with Fructus Forsythiae can relieve stagnation poison, control under item Goitre core；It, can be with tonifying lung dissolving phlegm and middle fall fire person with two old half summer grades of generation.Use is repaired above, must be wonderful with river person.If solving carbuncle poison, Broken crux, disappear real phlegm, applies malignant sore, and be preferred with native person.The lightly seasoned property of right river person is excellent, and native person's bitter is bad, and the two to use respectively.It is existing It is confirmed for medical research, bulbus fritillariae cirrhosae has significant antibechic and phlegm-dispelling functions, significantly inhibits pepsin and stress ulcer, inhibits Central nervous system.

Radix Glycyrrhizae: sweet in flavor；It is mild-natured.Return heart；Lung；Spleen；Stomach meridian.It invigorates the spleen and benefits qi；It is clearing heat and detoxicating；Expelling phlegm and arresting coughing；Relieving spasm to stop pain；It adjusts With all medicines.It cures mainly weakness of the spleen and the stomach；Fatigue and weakness；Shortness of breath and palpitation；Coughing with a lot of sputum；Four muscle spasm of the leg and foot pain of stomach duct and abdomen；Carbuncle sore tumefacting virus；Alleviate Drug toxicity.Compendium of Material Medica carries: " Radix Glycyrrhizae is monarch in all medicines.72 kinds of mammary calculus poison are controlled, draft is malicious by every means by Xie Yiqian bis-, adjusts With it is active from medicine." modern medical studies have confirmed that Radix Glycyrrhizae has stronger detoxication, there are also antiulcer, anti-inflammatory, antispastic antibechic, Lowering blood pressure and blood fat, antitumaous effect are widely used in treatment sphagitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis Etc. diseases, additionally have anti-gastric-ulcer, gastritis effect.

Pulp of dogwood fruit: sour；Slightly warm in nature returns liver；Kidney channel.It tonifies the liver and kidney；Astringing and avoiding visceroptosis, the major functions: waist is had a dizzy spell；Deaf ear Ring；Soreness and weakness of waist and knees；Xian essence spermatorrhoea；Frequent urination；Incessant sweating due to debility；Woman uterine bleeding." Elementary Medicine ": this astringent of Fructus Corni, what It is evil hair can be led to? covering all diseases is all the lower part cold of insufficiency type, with benefit nourishing liver and kidney, with Yi Qiyuan, then the five internal organs Amway, the person of closing is logical and benefit person Only, if the meaning of the light dredging of non-other medicine.Modern medicine study shows: pulp of dogwood fruit has antibacterial, adjusts immune, hypoglycemic, drop The functions such as blood lipid, anti-oxidant, anticancer, anti-AIDS, heart tonifying.

Thizoma curculiginis: acrid flavour；It is warm-natured；It is toxic.Enter kidney；Liver Channel.Warm kidney sun is strong；Dispel cold-dampness.Cure mainly impotence cold sperm；Urine is lost Prohibit；Coldness and pain in the epigastrium；Soreness of waist and knee joint；Muscles and bones is weak；Lower limb muscular constricture；Climacteric syndrome." sward pharmacological property standby will " carries: " kidney tonifying, only Bitterly, gonorrhoea is controlled, convulsive seizure due to phlegm-fire is managed, is stewed carnivorous.Ten, which steam nine, shines, and can strengthen spirit, black beard and hair." clinic study shows that thizoma curculiginis can be significant The phagocytosis of macrophage is improved, immune function is enhanced, hence it is evident that extends sleeping time, hence it is evident that extends toxin and causes convulsion effect Incubation period improves the activity of Na-ATP enzyme, and in addition there are antibacterial, antitumor, expansion coronary artery, heart tonifying, decompression and anti-inflammatory effects.

Compared with the prior art, the present invention has the following beneficial effects:

The present invention selects medicinal material monarch, minister, a left side, keeps all reasons all standby, and pharmacological property is mutually suitable mutually auxiliary, for initiation gynecomastia Liver kidney dystrophy, qi and blood is unsmooth, liver energy depression and phlegm stagnation, and the causes of disease such as qi depression to blood stasis are suited the remedy to the case, and has nourishing liver and kidney, liver soothing and depression relief, promoting blood circulation The effect of dredging collateral, reducing phlegm and resolving masses, good absorption effect is significant in efficacy, has no toxic side effect and clinical adverse, right according to clinical verification Gynecomastia cure rate is higher.

Specific embodiment

Present invention is further elaborated in following combination specific embodiment.

Embodiment 1

The raw material of effective ingredient of the present invention forms and weight are as follows:

The processing step of process for preparing medicine of the present invention are as follows:

(5) rhizoma cyperi is taken to clean slice, the rice vinegar for the amount of reordering is mixed thoroughly, after bored profit is sucked to vinegar, is set frying and is held in 3 devices, use Mild fire heats fried dry, and taking-up cools down.Clast is weeded out, crushing is ground, and is crossed 120 mesh dusting covers, is obtained fine powder, spare；

Usage and dosage: oral, 2 ball every time 3 times a day, severe patient 3 ball every time 3 times a day, before meals

It is taken with warm water or warm yellow rice wine within one hour, 24 days as a treatment course.

Embodiment 2

The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.

Embodiment 3

Clinical data:

1, case selection

60 clinical observations of gynecomastia patient that selection our hospital or outer court make a definite diagnosis, patient are randomly divided into two groups. Treatment group 30, male, the age 45~65 years old, average age 56.6 years old.Control group 30, male is the age 47~64 years old, average Age 55.4 years old.Two groups of qualifications are almost the same, and no significant difference is comparable.

2, treatment group patient takes drug of the present invention, takes orally, 3 times a day 2 ball every time, and severe patient 3 times a day every time 3 Ball is taken for one hour before meals with warm water or warm yellow rice wine, and 24 days as a treatment course take three courses for the treatment of.Control group is according to diagnosis The classification of gynecomastia out gives respectively using heptanesulfonic acid protona, tamoxifen, Clomifene, testosterone lactone Equal hormone medicines treatment.

3, efficacy determination:

(1) cure: clinical symptoms obviously disappear, and palpation lump disappears, and pain disappears.

(2) improve: clinical symptoms are substantially reduced, and palpation mass reduction, pain is relieved.

(3) invalid: pretherapy and post-treatment clinical symptoms are without substantially changeing.

4, result

21 are cured in treatment group, are improved 7, invalid 2, cure rate 70%, total effective rate 93.33%.

18 are cured in control group, are improved 8, invalid 4, cure rate 60%, total effective rate 86.67%.

The above results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group.

Typical case citing:

1, Zhao so-and-so, male, 47 years old, patient find double newborn enlargements and distending pain before half a year, carrys out our hospital's physical examination and goes to a doctor, through our hospital Physical examination sign is shown in double obvious enlargements of cream, and sign female breast, double accessible 11X11cm disk sample lumps of cream, matter is hard, the activity pushed away, Surface is smooth, clear border, and tenderness and the obvious of tenderness are diagnosed as gynecomastia (bilateral), of the present invention through taking Further consultation after 1 course for the treatment of of pill, double creams obviously collapse, and lump, which softens, to be reduced, then after even served two courses for the treatment of, lump all dissipates, touching Examine painless, bilateral breast restores normal, has cured.

2, Yang, male, 61 years old, the right cream of patient had lump to have distending pain sense nearly 2 years, carrys out our hospital's physical examination and goes to a doctor, disease is shown in the right side Side breast obvious tumefaction touches the big lump of 8x7cm under nipple, and clear border, the activity pushed away, surface is smooth, there is tenderness and tenderness Sense, left cream no abnormality seen is diagnosed as gynecomastia (right side), after being taken 1 course for the treatment of of pill of the present invention, lump Obvious soften is contracted to 5x5cm, and palpation pain is substantially reduced, then after even served two courses for the treatment of, lump dissipates, and palpation is painless, Right breast shape and left side no significant difference, have been cured.

From clinical treatment analysis of statistical data, this illness is mainly in the middle-aged and the old, and main cause liver-kidney deficiency is originally phlegm and qi stasis Blood stasis is mark, and pill of the present invention is mutually fitted mutually auxiliary from old complaint, pharmacological property, it is intended that liver-kidney tonifying, activating microcirculation and removing stasis medicinal, this mark are simultaneous It cares for.The nourishing liver and kidney of the Chinese medicine warms such as Cortex Eucommiae, the fleece-flower root, HERBA EPIMEDII, thizoma curculiginis, fructus lycii, pulp of dogwood fruit, coordinating Chong and Conception Vessels in side；Radix bupleuri, rhizoma cyperi Equal Chinese medicines liver-smoothing, qi-regulating, the Chinese medicines such as Rhizoma Atractylodis Macrocephalae, Poria cocos, dried orange peel, rhizoma pinellinae praeparata strengthening the spleen and stomach, promoting the circulation of qi resolving sputum, Radix Salviae Miltiorrhizae, radix cyathulae, curcuma zedoary, The activating microcirculation and removing stasis medicinal of the Chinese medicines such as Rhizoma Chuanxiong, reducing phlegm and resolving masses, then with Radix Glycyrrhizae coordinating the drug actions of a prescription, reach liver protection kidney-nourishing, activating microcirculation and removing stasis medicinal, rationally adjust in Secretion makes hormone in vivo level keep relative equilibrium, from the point of view of 30 therapeutic effects of this group, treats with pill of the present invention Gynecomastia, curative effect is very significant, and without side-effects.

Claims

1. a kind of pill for treating gynecomastia, it is characterised in that: the raw material composition of the pill effective component is made And parts by weight are as follows:

2. a kind of pill for treating gynecomastia according to claim 1, it is characterised in that: the pill is made The raw material of effective component forms and parts by weight are as follows:

3. a kind of pill for treating gynecomastia according to claim 1, it is characterised in that: the pill is made The raw material of effective component forms and parts by weight are as follows:

4. any a kind of pill for treating gynecomastia according to claim 1~3, it is characterised in that: including Following processing step:

(1) fructus lycii, pulp of dogwood fruit, cortex cinnamomi, Poria cocos, cortex moutan, radix bupleuri, dried orange peel, radix cyathulae, rhizoma pinellinae praeparata, tuber fleeceflower stem, Radix Glycyrrhizae are washed Only, it is uniformly mixed, is put into container after drying, the water of 6~8 times of amounts is added in a reservoir, heating is boiled 3~4 hours, after cooling Take immersion liquid；The water of 4~6 times of amounts is added in the remaining dregs of a decoction, heating is boiled 2~3 hours, takes immersion liquid after cooling；Merge two Secondary gained immersion liquid, heating are concentrated by evaporation as the thick paste of relative density 1.10~1.20, spare；

(2) fleece-flower root, teasel root, Semen Cuscutae are put into container, the shao-hsing rice wine of 3~5 times of amounts is added, is cooled after boiling, continued It impregnates 3~4 hours, takes immersion liquid；The shao-hsing rice wine that 2~3 times of amounts are added in the remaining dregs of a decoction, puts after boiling and dries in the air, continue to soak Bubble 2~3 hours, takes immersion liquid；Merge gained immersion liquid twice, adds the thick paste being concentrated by evaporation as relative density 1.15~1.25, it is standby With；

(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, radix paeoniae rubra, thizoma curculiginis are put into iron pan, the micro- stir-fry of mild fire, are fried to epidermis after turning yellow, spray Ji Me Lao Jiu, Continue fry to epidermis it is sallow after, taking-up cools, and crushing is ground, cross 120 mesh dusting covers, obtain fine powder, it is spare；

(5) rhizoma cyperi is taken to clean slice, the rice vinegar for the amount of reordering mixes thoroughly, after bored profit is sucked to vinegar, set in frying container, with mild fire plus Propagandize hotly dry, taking-up cools down, and weeds out clast, and crushing is ground, and crosses 120 mesh dusting covers, obtains fine powder, spare；

(7) it taking suet to enter heating fusing in pot, adds HERBA EPIMEDII and mix stir-frying to suet thoroughly and exhaust, medicinal material is crisp, clast is weeded out, Crushing is ground, and is crossed 120 mesh dusting covers, is obtained fine powder, spare；

(8) it takes Radix Salviae Miltiorrhizae, rhizoma alismatis to clean slice and dry, Radix Salviae Miltiorrhizae, rhizoma alismatis piece is added, stir-frying is sprayed even, fried dry for several times, with yellow rice wine, crushed It grinds, crosses 120 mesh dusting covers, obtain fine powder, it is spare；

It (9) will be by step (1), step (2) resulting thick paste, with step (3), step (4), step (5), step (6), step (7), fine powder obtained in step (8) mixes, and refined honey is added after mixing evenly, is prepared as the pill of every 10g.