CN104524096B - A kind ofly treat Chinese medicine preparation of deficiency of the liver and kidney dysmenorrhea and preparation method thereof - Google Patents
A kind ofly treat Chinese medicine preparation of deficiency of the liver and kidney dysmenorrhea and preparation method thereof Download PDFInfo
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Classifications
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Abstract
The invention discloses and a kind ofly treat Chinese medicine preparation of deficiency of the liver and kidney dysmenorrhea and preparation method thereof, belong to the field of Chinese medicines.It is that medicinal raw material is made by Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis, the Radix Aucklandiae, Rhizoma Cyperi, prescription of the present invention is terse, only be made up of seven taste Chinese medicines, there is high the kidney invigorating essence, moisten nourishing the liver blood, regulate the flow of vital energy and nourish blood, effect of menstruction regulating and pain relieving, can be made into multiple dosage form, for this disease treating both the principal and secondary aspects of a disease, excellent effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind ofly treat Chinese medicine preparation of deficiency of the liver and kidney dysmenorrhea and preparation method thereof.
Background technology
Dysmenorrhea is name premenstrual abdominal pain, abdominal pain during menstruation, menstrual abdominalgia, postmenstrual abdominal pain etc. also.Refer at each intermenstrual period, or occur lower abdomen and flank pain before and after passing through, even severe pain person unbearably, is called dysmenorrhea.Being one of commonly encountered diseases of women, is common with young women especially.
The disease of dysmenorrhea, sees Han dynasty " Medical Treasures of the Golden Chamber the miscellaneous internal diseases in woman arteries and veins is demonstrate,proved and controls ": " leukorrhagia, menstrual disorders, lower abdominal pain and fullness " the earliest." danxi's experiential therapy married woman " point out further dysmenorrhea can have have a pain through row, through after have a pain, and differentiate deficiency and excess.Blood stored in the liver, kidney storing essence, essence and blood alternate, yi and Kui are derived from the same origin, Liver and kidney is appointed originally for rushing, and essence and blood fills, and eight extra-channel is able to free and easy, and the sea of blood is quiet, passes unimpeded through water.If hepatic and renal YIN deficiency, the kidney failing to nourish the liver, wood loses bar and reaches, catharsis mistake department, functional activity of QI being not smooth, and vessels of the uterus is disorderly inverse and have a pain.
Visible deficiency of the liver and kidney dysmenorrhea is how not enough by natural endowment, and Liver and kidney deficiency in origin, or voluminous exhaustion due to sexual indulgence, undermine Liver and kidney, damage of essence insufficiency of blood, and punching is appointed not enough, and vessels of the uterus loses supports, will be clean and the sea of blood is more empty through water, and then causes the generation of dysmenorrhea.
Chinese traditional treatment primary disease shows unique characteristics, from Overall View Coryza Treated by Syndrome Differentiation, be dialectical main points according to the periodicity of menstrual onset and lower abdomen panic attacks, comprehensively analyze through amount, color, matter and arteries and veins disease according to the character of pain, degree, position referring and synthesizing, the object for the treatment of can be reached, the toxic and side effects of Western medicine can be avoided again.
Summary of the invention
Caused by liver and kidney deficiency, punching is appointed all empty, asthenia of essence and blood, and after passing through, the sea of blood is more empty, and vessels of the uterus loses supports, therefore after only lower abdomen dull pain; Damage of essence insufficiency of blood, deficiency of YIN affecting YANG, hypomenorrhea and the light matter of color is thin, empty and bearing-down sensation of the lower abdomen is not warm; Deficiency of kidney essence, YANG-orifices failing to be nourished, therefore dizziness and tinnitus; Waist is house of kidney, the then soreness of waist of suffering from a deficiency of the kidney.Therefore deficiency of the liver and kidney dysmenorrhea main symptom: lower abdomen dull pain, the soreness of waist after clean, through blood volume is few, matter is thin, light and dull menses, or has dizziness and tinnitus, and empty and bearing-down sensation of the lower abdomen is not warm, pale tongue, white and thin fur, deep-thready pulse.
Inventor is based on to the understanding of deficiency of the liver and kidney dysmenorrhea and Couple herbs, on the basis of forefathers, hammer away, meticulous compatibility, adopts modern crafts, provide a kind of Chinese medicine preparation for the treatment of deficiency of the liver and kidney dysmenorrhea, make it have nourishing the liver and kidney, regulate the flow of vital energy and nourish blood, the merit of menstruction regulating and pain relieving, for this disease treating both the principal and secondary aspects of a disease, excellent effect.
For achieving the above object, the present invention adopts following technical scheme:
A kind of Chinese medicine preparation for the treatment of deficiency of the liver and kidney dysmenorrhea, it is that medicinal raw material is made by Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis, the Radix Aucklandiae, Rhizoma Cyperi, and the weight portion of described each component is as follows: Semen Cuscutae 13-18 part, Radix Rehmanniae Preparata 16-21 part, Fructus Lycii 13-18 part, Herba Epimedii 8-13 part, Radix Angelicae Sinensis 9-15 part, Radix Aucklandiae 8-13 part, Rhizoma Cyperi 11-16 part.
For the dysmenorrhea that caused by liver and kidney deficiency causes, treatment must nourish kidney water to conserve edema with the liver involved.Semen Cuscutae sweet energy nourishing the liver and kidney in side, life essence-filling, marrow-benefitting, temperature can help taste; Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence fills out marrow, and two medicines share nourishing the liver and kidney, life essence-filling, marrow-benefitting power is strong, kidney energy store essential substances, liver energy store blood, and kidney essense can change raw liver blood, and this i.e. kidney water nourishing edema with the liver involved, and in the sufficient then kidney of kidney essense, negative and positive biochemistry has, and controlling its deficiency in origin, is monarch drug.The sweet temperature of Radix Angelicae Sinensis, kind the enriching blood of merit is invigorated blood circulation, menstruction regulating and pain relieving; Rhizoma Cyperi merit benefaction gas, menstruction regulating and pain relieving, two medicine compatibilities, had both enriched blood and had invigorated blood circulation, and menstruction regulating and pain relieving controls its mark again, is ministerial drug.Herba Epimedii is warm in nature, kidney-replenishing, bone and muscle strengthening, gets the justice for the treatment of YIN within YANG, and Fructus Lycii is put down, and nourishing the liver and kidney, asks cloudy Zhong Yuyangzhi road, YIN and YANG balancing like this, biochemical infinite, is adjuvant drug.The Radix Aucklandiae returns spleen, stomach, large intestine, tri-jiao channel, has both helped ministerial drug regulating QI to relieve pain, again strengthening the spleen to promote digestion, makes benefit and not high, is adjuvant.We's organic compatibility, high the kidney invigorating essence, moisten nourishing the liver blood, regulate the flow of vital energy and nourish blood, menstruction regulating and pain relieving, all diseases disappear, evident in efficacy.
Preferably, the Chinese medicine preparation for the treatment of deficiency of the liver and kidney dysmenorrhea described above, is characterized in that the weight portion of described each component is as follows: Semen Cuscutae 15-17 part, Radix Rehmanniae Preparata 18-21 part, Fructus Lycii 14-17 part, Herba Epimedii 9-11 part, Radix Angelicae Sinensis 11-15 part, Radix Aucklandiae 9-12 part, Rhizoma Cyperi 14-16 part.
The preferred version of the present invention optimized further: a kind of Chinese medicine preparation for the treatment of deficiency of the liver and kidney dysmenorrhea, is characterized in that the weight portion of described each component is as follows: Semen Cuscutae 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Lycii 15 parts, Herba Epimedii 10 parts, Radix Angelicae Sinensis 13 parts, the Radix Aucklandiae 10 parts, Rhizoma Cyperi 15 parts.
The pharmaceutical research present situation of the present invention's each medicinal raw material used is as follows:
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Fructus Lycii: sweet is flat.Return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Herba Epimedii: acrid, sweet, warm.Return liver, kidney channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
The Radix Aucklandiae: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Cyperi: pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Present invention also offers a kind of preparation method of Chinese medicine preparation described above, it mainly comprises following step: the Radix Aucklandiae, Rhizoma Cyperi add the water of 4-6 times of weight portion, soak 2-3 hour, distillation extraction 2-3 hour, collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 4-6 times of weight portion that add water 2 times, each 1.5-2 hour, merge decoction liquor, adding ethanol to concentration is 50-60%, places 8-12 hour, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make clinical receptible dosage form by conventional formulation method.
Described above clinical institute receptible dosage form such as, powder, pill, granule, tablet, capsule, dispersible tablet, slow releasing tablet, oral liquid etc.
Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into tablet, capsule, granule.
Further illustrate beneficial effect of the present invention by clinical observation test, details are as follows:
1. physical data: select deficiency of the liver and kidney primary dysmenorrhea patient 80 example of going to a doctor in July, 8 ~ 2014 in 2013 in my institute, be divided into treatment group and matched group at random, each 40 examples.18 ~ 37 years old treatment group age, average (25.2 ± 5.5) year, the course of disease 1 ~ 8 year, average (2.8 ± 1.4) year; 18 ~ 36 years old matched group age, average (25.5 ± 5.7) year, the course of disease 1 ~ 8 year, average (3.2 ± 1.5) year.Two groups of physical data, through statistical procedures difference nonsignificance (P > 0.05), have comparability.
2. diagnostic criteria: Western medicine diagnose is according to " newly organized practical gynecology " (Su Yingkuan, Shandong science tech publishing house, 2005).Menstrual period or before and after row lower abdomen pain, pain and waist sacrum, very then faint, in periodical attack; Tcm diagnosis according to " petty official by heavenly maiden section face card record will " (Xu Jingsheng, Xu Bo, Wang Maoni, etc., People's Health Publisher, 2010:193).
3. exclusion standard: have significant organic pathological changes person through gynecologial examination; Those who are allergic to this drug; Be associated with severe primary disease, the psychotics such as cardiovascular, liver, kidney and hemopoietic system; Menstrual cycle is irregular, and affect the treatment judgement person; Do not take medicine by regulation, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
4. Therapeutic Method
Treatment group: take capsule prepared by the embodiment of the present invention 1, each 2-3 grain, every 0.4g (being equivalent to crude drug 1.5g), sooner or later 2 sub-services, each menstrual cycle started to take medicine from premenstrual 5 days, serve on 7 days (generally within the 3rd day, stopping in menstrual onset), 3 cycles for the treatment of were 1 course for the treatment of continuously.
Matched group: dysmenorrhea outbreak time take ibuprofen modified release capsule (Sino-U.S.'s Tianjin history can pharmaceutical Co. Ltd produce, specification 0.3g × 20), 1 time 1, every day 1 time.Continuous treatment 3 menstrual cycle are 1 course for the treatment of.
Two groups of patients all inform, note menstrual hygiene, note rule of life.
5. observation index: clinical symptoms, scoring situation, untoward reaction.
6. criterion of therapeutical effect and tcm symptom improve situation:
Dysmenorrhea criterion of therapeutical effect formulates dysmenorrhea curative effect determinate standard with reference to " guideline of clinical investigations for the treatment of by Chinese herbs dysmenorrhea ": dysmenorrhea integration evaluation criteria: (1) lower abdominal distention pain: even promising 1 ~ 3 point; Frequently as 4 ~ 6 points; Continue to appear as 7 ~ 9 points.(2) lumbosacral aching pain: even have outbreak 1 ~ 3 point; Recurrent exerbation 4 ~ 6 points; Continue outbreak 7 ~ 9 points.(3) dysmenorrhea: mild pain 1 ~ 3 point; Moderate pain 4 ~ 6 points; Severe pain 7 ~ 9 points.
Curative effect determinate standard adopts in " guideline of clinical investigations for the treatment of by Chinese herbs dysmenorrhea ", therapeutic index=[before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.Recovery from illness: stomachache and other transference cures, drug withdrawal 3 non-recidivists of menstrual cycle, integration reduces >=95%; Effective: stomachache obviously alleviates, all the other symptoms take a turn for the better, and drug withdrawal 3 menstrual cycle symptoms do not increase the weight of, and after 90%> treatment, integration reduces >=70%; Effective: stomachache alleviates, other symptoms take a turn for the better, though symptom repeatedly, comparatively alleviates before treatment after drug withdrawal, after 70%> treatment, integration reduces >=30%; Invalid: stomachache and other symptoms are without change or add severe one, and after treatment, integration reduces <30%.
7. statistical method: adopt SPSS15.0 statistical software to calculate.Each numerical value with
represent, measurement data adopts t inspection, and enumeration data adopts χ
2inspection, ranked data Ridit analyzes.
8. result
Treatment group total effective rate is 95.0%, matched group total effective rate is 70.0%, two groups of comparitive study difference significances (P<0.05), show that the curative effect of Drug therapy deficiency of the liver and kidney dysmenorrhea of the present invention is better than ibuprofen modified release capsule.In table 1.
Table 1 liang group Clinical efficacy comparison, example
Treat the symptom integral no significant difference (P>0.05) of front two groups of patients, there is comparability.Treatment after symptom total mark, two groups comparatively treat before all have statistical significance (P<0.01).After treatment, between two groups of groups, comparing difference has statistical significance (P<0.05).In table 2.
Before and after table 2 liang group patient treatment, TCM symptom score compares
point
Note: compare with before treatment: * P<0.01; Compare between two groups after treatment:
#p<0.05.
By the observation to treatment group patient medication overall process, have no toxic and side effects and occur.
Visible, medicine of the present invention compared with prior art, have significant progressive, promote the use of by clinic.
Beneficial effect of the present invention:
1. Chinese medicine composition of the present invention has nourishing the liver and kidney, regulates the flow of vital energy and nourishes blood, effect of menstruction regulating and pain relieving, for this disease treating both the principal and secondary aspects of a disease.
2. Chinese medicine composition prescription of the present invention is terse, is only made up of seven taste Chinese medicines, but excellent effect.
3. can be made into multiple dosage form, facilitate clinical portably using.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Semen Cuscutae 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Lycii 15 parts, Herba Epimedii 10 parts, Radix Angelicae Sinensis 13 parts, the Radix Aucklandiae 10 parts, Rhizoma Cyperi 15 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 5 times of weight portions, soaks 2.5 hours, distillation extraction 2.5 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 5 times of weight portions that add water 2 times, each 2.0 hours, merge decoction liquor, adding ethanol to concentration is 55%, places 10 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make capsule by conventional formulation method.
Embodiment 2
Prescription: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 18 parts, Fructus Lycii 14 parts, Herba Epimedii 9 parts, Radix Angelicae Sinensis 11 parts, the Radix Aucklandiae 9 parts, Rhizoma Cyperi 14 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 4 times of weight portions, soaks 3 hours, distillation extraction 2 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 6 times of weight portions that add water 2 times, each 1.5 hours, merge decoction liquor, adding ethanol to concentration is 50%, places 12 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make capsule by conventional formulation method.
Embodiment 3
Prescription: Semen Cuscutae 17 parts, Radix Rehmanniae Preparata 21 parts, Fructus Lycii 17 parts, Herba Epimedii 11 parts, Radix Angelicae Sinensis 15 parts, the Radix Aucklandiae 12 parts, Rhizoma Cyperi 16 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 6 times of weight portions, soaks 3 hours, distillation extraction 3 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 4 times of weight portions that add water 2 times, each 1.5 hours, merge decoction liquor, adding ethanol to concentration is 60%, places 8 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make capsule by conventional formulation method.
Embodiment 4
Prescription: Semen Cuscutae 17 parts, Radix Rehmanniae Preparata 18 parts, Fructus Lycii 15 parts, Herba Epimedii 10 parts, Radix Angelicae Sinensis 14 parts, the Radix Aucklandiae 11 parts, Rhizoma Cyperi 14 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 5 times of weight portions, soaks 2.5 hours, distillation extraction 3 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 4 times of weight portions that add water 2 times, each 2 hours, merge decoction liquor, adding ethanol to concentration is 55%, places 12 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make tablet by conventional formulation method.
Embodiment 5
Prescription: Semen Cuscutae 16 parts, Radix Rehmanniae Preparata 19 parts, Fructus Lycii 15 parts, Herba Epimedii 10 parts, Radix Angelicae Sinensis 13 parts, the Radix Aucklandiae 12 parts, Rhizoma Cyperi 14 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 5 times of weight portions, soaks 2.5 hours, distillation extraction 2 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 6 times of weight portions that add water 2 times, each 1.5 hours, merge decoction liquor, adding ethanol to concentration is 60%, places 10 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make tablet by conventional formulation method.
Embodiment 6
Prescription: Semen Cuscutae 13 parts, Radix Rehmanniae Preparata 16 parts, Fructus Lycii 13 parts, Herba Epimedii 8 parts, Radix Angelicae Sinensis 9 parts, the Radix Aucklandiae 8 parts, Rhizoma Cyperi 11 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 4 times of weight portions, soaks 2.5 hours, distillation extraction 2.5 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 5 times of weight portions that add water 2 times, each 2 hours, merge decoction liquor, adding ethanol to concentration is 55%, places 10 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make tablet by conventional formulation method.
Embodiment 7
Prescription: Semen Cuscutae 18 parts, Radix Rehmanniae Preparata 21 parts, Fructus Lycii 18 parts, Herba Epimedii 13 parts, Radix Angelicae Sinensis 15 parts, the Radix Aucklandiae 13 parts, Rhizoma Cyperi 16 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 5 times of weight portions, soaks 3 hours, distillation extraction 3 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 4 times of weight portions that add water 2 times, each 1.5 hours, merge decoction liquor, adding ethanol to concentration is 54%, places 10 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make granule by conventional formulation method.
Embodiment 8
Prescription: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 18 parts, Fructus Lycii 15 parts, Herba Epimedii 12 parts, Radix Angelicae Sinensis 13 parts, the Radix Aucklandiae 9 parts, Rhizoma Cyperi 13 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 5 times of weight portions, soaks 2 hours, distillation extraction 3 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 5 times of weight portions that add water 2 times, each 2 hours, merge decoction liquor, adding ethanol to concentration is 50%, places 8 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make granule by conventional formulation method.
Embodiment 9
Prescription: Semen Cuscutae 18 parts, Radix Rehmanniae Preparata 18 parts, Fructus Lycii 14 parts, Herba Epimedii 8 parts, Radix Angelicae Sinensis 13 parts, the Radix Aucklandiae 12 parts, Rhizoma Cyperi 12 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 6 times of weight portions, soaks 3 hours, distillation extraction 3 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 4 times of weight portions that add water 2 times, each 1.5 hours, merge decoction liquor, adding ethanol to concentration is 60%, places 12 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make pill by conventional formulation method.
Embodiment 10
Prescription: Semen Cuscutae 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Lycii 15 parts, Herba Epimedii 10 parts, Radix Angelicae Sinensis 13 parts, the Radix Aucklandiae 10 parts, Rhizoma Cyperi 15 parts.
Preparation method: the Radix Aucklandiae, Rhizoma Cyperi add the water of 5 times of weight portions, soaks 2.5 hours, distillation extraction 2.5 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 5 times of weight portions that add water 2 times, each 2.0 hours, merge decoction liquor, adding ethanol to concentration is 55%, places 10 hours, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make oral liquid by conventional formulation method.
Claims (4)
1. treat the Chinese medicine preparation of deficiency of the liver and kidney dysmenorrhea for one kind, it is that medicinal raw material is made by Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis, the Radix Aucklandiae, Rhizoma Cyperi, it is characterized in that the weight portion of described each component is as follows: Semen Cuscutae 15-17 part, Radix Rehmanniae Preparata 18-21 part, Fructus Lycii 14-17 part, Herba Epimedii 9-11 part, Radix Angelicae Sinensis 11-15 part, Radix Aucklandiae 9-12 part and Rhizoma Cyperi 14-16 part.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that the weight portion of described each component is as follows: Semen Cuscutae 16 parts, Radix Rehmanniae Preparata 20 parts, Fructus Lycii 15 parts, Herba Epimedii 10 parts, Radix Angelicae Sinensis 13 parts, the Radix Aucklandiae 10 parts and Rhizoma Cyperi 15 parts.
3. the Chinese medicine preparation as described in as arbitrary in claim 1-2, it is characterized in that its preparation method comprises the following steps: the Radix Aucklandiae, Rhizoma Cyperi add the water of 4-6 times of weight portion, soak 2-3 hour, distillation extraction 2-3 hour, collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and the another device of debris are deposited; After Semen Cuscutae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Epimedii, Radix Angelicae Sinensis and the Radix Aucklandiae, Rhizoma Cyperi extract volatile oil, medicinal residues, debris merge, the soak by water of the 4-6 times of weight portion that add water 2 times, each 1.5-2 hour, merge decoction liquor, adding ethanol to concentration is 50-60%, places 8-12 hour, filters to obtain alcohol deposit fluid, decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds volatile oil clathrate compound, add appropriate amount of auxiliary materials mixing again, make clinical receptible dosage form by conventional formulation method.
4. Chinese medicine preparation as claimed in claim 3, is characterized in that it makes granule, tablet or capsule.
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