CN104511048B - A kind of antibacterial suture of degradable metal - Google Patents
A kind of antibacterial suture of degradable metal Download PDFInfo
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- CN104511048B CN104511048B CN201310451040.3A CN201310451040A CN104511048B CN 104511048 B CN104511048 B CN 104511048B CN 201310451040 A CN201310451040 A CN 201310451040A CN 104511048 B CN104511048 B CN 104511048B
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Abstract
The invention provides a kind of antibacterial suture of degradable metal, including one or more strands of silk threads, described silk thread is magnesium-base metal material, and wherein the content of magnesium is 90 100wt%.The antibacterial suture of described degradable metal also includes the syringe needle being connected with wire ends.The present invention provide the antibacterial suture of degradable metal there is good degradation rate, in degradation process, discharge various trace elements, it is possible to promote skin healing, can local antibacterial, tissue reaction is little.
Description
Technical field
The present invention relates to a kind of bio-medical material, particularly relate to a kind of antibacterial suture of degradable metal.
Background technology
Absorbable suture use in surgical departments has had the history of decades.Commonly using absorbable suture class clinically is mainly catgut and synthetic line, such as Dexon (PGA, polyglycolic acid), Maxon (poly-glycol carbonic acid), Vicryl (Polyglactin910, polylactic-co-glycolic acid), PDS (Polydioxanone, poly-dioxa cyclohexanone) and PVA (poly-acetic acid vinylon) etc. at present.Such as CN1363397A discloses a kind of process for preparing medical suture bio-silk from goat intestines, and clean goat casing is the most longitudinally broken into 2-4 bar, puts in the sodium hydroxide solution of 10-30% and soak after cleaning casing inwall；Take out and clean, at normal temperatures with hydrogen peroxide bleaching 4-8 hour of 0.1-0.4%, apply animal collagen after taking-up on its surface, reach wire body soft；By machine line and dry at normal temperatures, then with buffing machine, wire body is polished, make wire body bright and clean；After physical property detection is qualified, reperfusion protection liquid also carries out sterilizing to wire body and protection liquid, packs, puts in storage.And for example CN201543004U discloses and a kind of repairs mesh sheet and the fiber of anti diaphragm for surgical sutures, hernia and body wall, and including polypropylene core, polyvinylidene fluoride cortex, sandwich layer, cortex are concentric structure, form concentric structure composite fibre through composite spinning.
But owing to its soak time is longer, often find that foreign body reaction occurs.Finding a kind of degradation time moderate, it is possible to promote tissue or skin healing, the absorbable suture material of local antibacterial is always clinician and the target of material scholar joint efforts.
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency, it is provided that a kind of antibacterial suture of degradable metal, it is possible to promote tissue or skin healing, and local antibacterial, absorbable.
The invention provides a kind of antibacterial suture of degradable metal, including one or more strands of silk threads, described silk thread is magnesium-base metal material, wherein the content of magnesium is 90-100wt%, more preferably 91-99.999wt%, more preferably 93-99.99wt%, more preferably 94-99.99wt%, more preferably 95-99.99wt%.
A diameter of 0.01-5mm of described silk thread, more preferably 0.01-3.5mm, more preferably 0.01-2mm, more preferably 0.1-1.5mm, more preferably 0.5-1mm.
According to disease character and treatment needs, described magnesium-base metal material can select pure magnesium or the magnesium base alloy with other element combinations.
In described magnesium base alloy outside demagging element, it is also possible to containing one or more in copper, zinc, manganese, selenium, strontium, calcium, ferrum, zirconium, stannum, nickel, aluminum, silver etc., and/or one or more in rare earth metal.
Described rare earth metal includes scandium, yttrium, lanthanum, cerium, praseodymium, neodymium, hard iron, samarium, europium, gadolinium, terbium, dysprosium, neodymium, holmium, erbium, thulium, ytterbium, lutecium.
Wherein, described magnesium base alloy can also contain one or more in a small amount of impurity element, such as rare earth element, and/or one or more in ferrum, zirconium, stannum, nickel, copper, silver and aluminum.
Preferably, every kind of content in described impurity element is less than 1wt%, more preferably less than 0.5wt%, more preferably less than 0.1wt%, more preferably less than 0.05wt%.
Preferably, described impurity element total amount is less than 2wt%, more preferably less than 1wt%, more preferably less than 0.5wt%, more preferably no more than 0.3wt%, more preferably less than 0.1wt%.
In a preferred embodiment, the antibacterial suture of described degradable metal also includes the syringe needle being connected with wire ends.
Preferably, the end plating hard metal of described silk thread, it is polished into pointed formation syringe needle.
Wherein, the hard metal of the end plating stating silk thread described in is titanium, tungsten, titanium alloy, tungsten alloy, steel or other hard alloys.
Preferably, described syringe needle is hard metal staight needle syringe needle or looper syringe needle, such as, can be stainless pin head.
Preferably, the tail end of described syringe needle is provided with the pin hole allowing that described silk thread passes.
Preferably, described syringe needle is that hollow can self-locking hard metal staight needle syringe needle or looper syringe needle.Being become by two pin lobeds of described syringe needle, the front end of two pin lobes is connected as a single entity and forms the needle point of syringe needle, two pin lobes surface (being properly termed as the inner surface of pin lobe) close to each other is provided with the latching member cooperated, and it is additionally provided with groove on two pin lobes surface close to each other, described groove connects with the tail end of pin lobe, under external force, after latching member self-locking, the groove on the surface that two pin lobes are close to each other forms the passage accommodating described silk thread.
It is further preferred that the diameter of described passage is less than the diameter of described silk thread, thus after latching member self-locking, described silk thread can be clamped by two pin lobes.
Further preferably, between described groove and latching member, width and/or the degree of depth big groove more than described groove it is additionally provided with on the surface that said two pin lobe is close to each other, and described big groove is interconnected with described groove, under external force, after latching member self-locking, big groove on the surface that two pin lobes are close to each other forms the space of the end accommodating described silk thread, and the end of described silk thread can not depart from from described space, the internal diameter of the passage of the groove formation on the surface that the Breadth Maximum of the end of the most described silk thread is close to each other more than two pin lobes.
The end of described silk thread can be that length is more than the plane of wire body cross-sectional area, triangular pyramidal, tetragonal body, many cubes, spheroid etc. more than the strip of wire body diameter, area.
Preferably, the inner surface of a pin lobe in said two pin lobe is provided with projection, described projection includes projection and projection, described projection connects described projection and the inner surface of pin lobe, the diameter of described projection is less than the minimum widith of the lower surface of described projection, the lower surface of described projection is plane, upper surface is arcwall face, the inner surface of another pin lobe in said two pin lobe is provided with the hole accommodating described projection, the diameter of the opening of described hole is less than the Breadth Maximum of the lower surface of (should be understood to be slightly less than) described projection, and the thickness of the opening part of described hole is equal to the height of described projection, under the effect of external force, described projection can be squeezed in described hole, form self-locking structure.
Preferably, the latching member that cross section is 7 fonts it is respectively equipped with on inner surface in said two pin lobe, described latching member includes horizontal block and cylinder, described horizontal block one end is connected formation 7 fonts with cylinder, described cylinder is connected with the inner surface of pin lobe away from one end of horizontal block, the height of described cylinder is more than the thickness of horizontal block, and the other end that described horizontal block is not connected with cylinder is self-locking end；The self-locking end of the horizontal block on the inner surface of two pin lobes is right in opposite directions, and two the outer surface (away from the surface of this horizontal block place pin lobe inner surface on horizontal block) of horizontal block contact with each other, under the effect of external force, two horizontal blocks can occur less relative displacement, it is mutually clamped, the inner surface (near the surface of this horizontal block place pin lobe inner surface on horizontal block) making two horizontal blocks contacts with each other, and forms self-locking structure.
It is further preferred that the self-locking end of described horizontal block is inclined-plane, and the acute angle on inclined-plane is towards this horizontal block place pin lobe inner surface；Or the self-locking end of described horizontal block is arcwall face.
Preferably, the inner surface portion of described pin lobe is raised, and directly substitutes described cylinder.
Wherein, described silk thread is compact texture or loose structure.
In a preferred embodiment, described silk thread it is coated with degradable macromolecule coating, degradable ceramic coating and promotes one or more in skin composition healing substances.
The composition material of degradable macromolecule coating is preferably Poly(D,L-lactide-co-glycolide (PLGA), polyglycolic acid (PGA), polylactic acid (PLA), PLLA (PLLA), polycaprolactone (PCL), poly-hydroxy acrylate (PACA), gathers one or more in dioxane ketone, condensing model, poly phosphazene, polymer-amino-acid, poly-B-butyric ester and hydroxypentanoic acid fat and copolymer etc. thereof.
The composition material of degradable ceramic coating is preferably one or more of hydroxyapatite, strontium containing hydroxyapatite, Silicon-Substituted Hydroxyapatite, B-trialcium phosphate and phosphoric acid oxygen four calcium.
Promote that skin composition healing substances can be one or more of collagen protein or other biological coating.
The thickness of biodegradable coating is preferably 0.01-10mm, more preferably 0.05-5mm, more preferably 0.05-2mm, such as 0.5mm, 1mm, 1.5mm, 2mm.
Preferably, described implant is wire or bar-shaped.
It is further preferred that a length of 1-100cm of described implant, more preferably 5-50cm, more preferably 10-50cm, more preferably 20-50cm, such as 20cm, 30cm, 40cm or 50cm.
The present invention provide the antibacterial suture of degradable metal there is good degradation rate, in degradation process, discharge various trace elements, it is possible to promote skin healing, can local antibacterial, tissue reaction is little.
Accompanying drawing explanation
Fig. 1 is the structural representation of the antibacterial suture of degradable metal in the first embodiment of the present invention；
Fig. 2 is the structural representation of the silk thread of the antibacterial suture of degradable metal in the second embodiment of the present invention；
Fig. 3 is the sectional view of the syringe needle of the antibacterial suture of degradable metal in the second embodiment of the present invention, and a is outside drawing, and b is sectional view during non-self-locking, and c is sectional view during self-locking；
Fig. 4 is the silk thread of the antibacterial suture of degradable metal, staight needle syringe needle and the structural representation of looper syringe needle in the third embodiment of the present invention.
Detailed description of the invention
With reference to the accompanying drawings, the invention will be further described in conjunction with specific embodiments, to be more fully understood that the present invention.
Embodiment 1
With reference to Fig. 1, the antibacterial suture of degradable metal that the present embodiment provides includes magnesium-base metal silk thread 1, and magnesium-base metal silk thread 1 is higher than the pure magnesium of 99.99wt%, a diameter of 0.5mm, after testing mechanical strength 200Mpa, elongation percentage 20% for purity.The end titanizing of silk thread 1, sharpening forms syringe needle 2.
Biological safety: carry out biological assessment according to experimental technique described in GB/T16886.Test result indicate that, the present embodiment material does not has obvious cytotoxicity and hemagglutinin to fibroblast, does not has obvious sensitization, stimulation and genetoxic.
Interior animal experiment and material degradation situation:
Select the SD rat at 30 6 monthly ages, back preserved skin, do long 5cm otch.It is randomly divided into A, B group, often group 15.The antibacterial suture of degradable metal that the present embodiment provides, B group PGA silk suture.Rat skin healing state after observing 5,10,15,20,30, HE organizes, histological score, blood vessel number, masson dyes, substantially sxemiquantitative (GB/T16886.10: acute inflammation, chronic inflammatory disease, foreign body reaction, fibrosis, erythema and eschar are formed, and edema is formed), lymphocyte grade etc..Experimental result shows, compared to B group, the A group skin healing time is early, masson dyeing display A group surrounding materials collagen component increases, substantially sxemiquantitative finds that A group tissue reaction is little, NIP reacts, illustrate the antibacterial suture of degradable metal that the present embodiment provides can promote skin healing, can local antibacterial, tissue reaction little.Material degrades 35%, 60% respectively on the 15,30th.
Embodiment 2
With reference to Fig. 2 and Fig. 3, the antibacterial suture of degradable metal that the present embodiment provides includes magnesium-base metal silk thread 1 and syringe needle 2, and the end 11 of described magnesium-base metal silk thread 1 is spherical.Described magnesium-base metal silk thread 1 is Mg-Zn-Ca alloy (content of magnesium is 94wt%), a diameter of 0.4mm, after testing, mechanical strength 180Mpa, elongation percentage 18%.
Syringe needle 2 is become by two pin lobeds, the front end of two pin lobes is connected as a single entity and forms the needle point of syringe needle 2, two pin lobes surface (being properly termed as the inner surface of pin lobe) close to each other is provided with the latching member cooperated, and it is additionally provided with groove on two pin lobes surface close to each other, described groove connects with the tail end of pin lobe, under external force, after latching member self-locking, the groove on the surface that two pin lobes are close to each other forms the passage 21 accommodating described silk thread.
The diameter of passage is slightly less than the diameter of described silk thread, thus after latching member self-locking, described silk thread can be clamped by two pin lobes.
In one preferred embodiment, between described groove and latching member, width and/or the degree of depth big groove more than described groove it is additionally provided with on the inner surface of described pin lobe, and described big groove is interconnected with described groove, under external force, after latching member self-locking, big groove on the surface that two pin lobes are close to each other forms the space 22 of the end accommodating described silk thread, and the end of described silk thread can not depart from from described space, the internal diameter of the passage 21 that the groove on surface that the Breadth Maximum of the end 11 of the most described silk thread is close to each other more than two pin lobes is formed.
The latching member that cross section is 7 fonts it is respectively equipped with on inner surface in said two pin lobe, described latching member includes horizontal block and cylinder, described horizontal block one end is connected formation 7 fonts with cylinder, described cylinder is connected with the inner surface of pin lobe away from one end of horizontal block, the height of described cylinder is more than the thickness of horizontal block, and the other end that described horizontal block is not connected with cylinder is self-locking end；The self-locking end of the horizontal block on the inner surface of two pin lobes is right in opposite directions, and two the outer surface (away from the surface of this horizontal block place pin lobe inner surface on horizontal block) of horizontal block contact with each other, the self-locking end of described horizontal block is inclined-plane, and the acute angle on inclined-plane towards this horizontal block place pin lobe inner surface under the effect of external force, two horizontal blocks can occur less relative displacement, it is mutually clamped, makes the inner surface (near the surface of this horizontal block place pin lobe inner surface on horizontal block) of two horizontal blocks contact with each other, form self-locking structure.
The inner surface portion of the most described pin lobe is raised, and directly substitutes described cylinder.
During use, being placed in the big groove of a certain pin lobe the end 11 of magnesium-base metal silk thread 1, silk thread is placed in groove, by two pin lobe Guan Bis, under external force, two horizontal block generation relative displacements, is mutually clamped, and forms self-locking structure, two pin lobe laminatings, is clamped by silk thread.
Biological safety: carry out biological assessment according to experimental technique described in GB/T16886.Test result indicate that, the present embodiment material does not has obvious cytotoxicity and hemagglutinin to fibroblast, does not has obvious sensitization, stimulation and genetoxic.
Interior animal experiment and material degradation situation:
Select the SD rat at 30 6 monthly ages, back preserved skin, do long 5cm otch.It is randomly divided into A, B group, often group 15.The antibacterial suture of degradable metal that the present embodiment provides, B group PGA silk suture.Rat skin healing state after observing 5,10,15,20,30, HE organizes, histological score, blood vessel number, masson dyes, substantially sxemiquantitative (GB/T16886.10: acute inflammation, chronic inflammatory disease, foreign body reaction, fibrosis, erythema and eschar are formed, and edema is formed), lymphocyte grade etc..Experimental result shows, compared to B group, the A group skin healing time is early, masson dyeing display A group surrounding materials collagen component increases, substantially sxemiquantitative finds that A group tissue reaction is little, NIP reacts, illustrate the antibacterial suture of degradable metal that the present embodiment provides can promote skin healing, can local antibacterial, tissue reaction little.Material degrades 40%, 80% respectively on the 15,30th.
Embodiment 3
The antibacterial suture of degradable metal that the present embodiment provides includes magnesium-base metal silk thread 1 and syringe needle 2, and the tail end of syringe needle 2 is provided with the pin hole 20 allowing that described silk thread passes.Syringe needle 2 can be staight needle (Fig. 4 d) or looper (Fig. 4 e).
Being described in detail the specific embodiment of the present invention above, but it is intended only as example, the present invention is not restricted to particular embodiments described above.To those skilled in the art, any equivalent modifications carrying out the present invention and replacement are the most all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and amendment, all should contain within the scope of the invention.
Claims (7)
1. the antibacterial suture of degradable metal, it is characterised in that include that one or more strands of silk thread, described silk thread are
Magnesium-base metal material, wherein the content of magnesium is 90-100wt%；
Also include the syringe needle being connected with wire ends；
Described syringe needle is hard metal staight needle syringe needle or looper syringe needle；
Being become by two pin lobeds of described syringe needle, the front end of two pin lobes is connected as a single entity and forms the needle point of syringe needle, and two
Individual pin lobe surface close to each other is provided with the latching member cooperated, and the surface that two pin lobes are close to each other
On be additionally provided with groove, described groove connects with the tail end of pin lobe, under external force, after latching member self-locking,
Groove on the surface that two pin lobes are close to each other forms the passage accommodating described silk thread.
The antibacterial suture of degradable metal the most according to claim 1, it is characterised in that the diameter of described silk thread
For 0.01-5mm.
The antibacterial suture of degradable metal the most according to claim 1, it is characterised in that described magnesium-base metal material
Material is containing a small amount of impurity element, and described impurity element is one or more in rare earth element, and/or ferrum, zirconium,
One or more in stannum, nickel, copper, silver and aluminum, every kind of content in impurity element is less than 1wt%.
The antibacterial suture of degradable metal the most according to claim 1, it is characterised in that the end of described silk thread
Plating hard metal, is polished into pointed formation syringe needle.
The antibacterial suture of degradable metal the most according to claim 1, it is characterised in that two pin lobes mutually lean on
Between described groove and latching member, it is additionally provided with width near surface and/or the degree of depth is more than the big of described groove
Groove, and described big groove is interconnected with described groove, under external force, after latching member self-locking, two
Big groove on the surface that pin lobe is close to each other forms the space of the end accommodating described silk thread, and described silk thread
End can not depart from from described space.
The antibacterial suture of degradable metal the most according to claim 1, it is characterised in that described silk thread is fine and close
Structure or loose structure.
The antibacterial suture of degradable metal the most according to claim 1, it is characterised in that coat on described silk thread
There are degradable macromolecule coating, degradable ceramic coating and promote the one or many in skin composition healing substances
Kind.
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| CN201310451040.3A CN104511048B (en) | 2013-09-27 | 2013-09-27 | A kind of antibacterial suture of degradable metal |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA3004690A1 (en) * | 2015-11-12 | 2017-05-18 | Curical Technologies Ltd. | Biocompatible articles with embedded copper ions and copper ion releasing coating |
| WO2018122066A1 (en) * | 2016-12-28 | 2018-07-05 | Meotec GmbH & Co. KG | Assembly comprising a resorbable material having antibacterial activity |
| CN108721707B (en) * | 2017-04-25 | 2021-04-09 | 北京纳米能源与***研究所 | Degradable lead and preparation method thereof |
| CN109316624B (en) * | 2017-07-31 | 2021-07-02 | 中国科学院金属研究所 | Integrated degradable cartilage connecting suture with needle |
| ES2928569T3 (en) * | 2018-01-31 | 2022-11-21 | Titanium Textiles Ag | Composite surgical suture material based on polyfilamentous titanium thread and bioresorbable polymers |
| CN109770981B (en) * | 2019-02-15 | 2022-04-01 | 上海交通大学医学院附属第九人民医院 | Metal suture or skin nail for postoperative incision suturing and preparation method thereof |
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| AU2006202432B2 (en) * | 2005-07-11 | 2012-05-17 | Covidien Lp | Antimicrobial sutures and methods of making them |
| CN101214396A (en) * | 2008-01-03 | 2008-07-09 | 乐普（北京）医疗器械股份有限公司 | Controlled degradation magnesium alloy coating bracket and preparation thereof |
| CN102512214A (en) * | 2012-01-10 | 2012-06-27 | 梁杰 | Non-removing antibacterial skin suture for cosmetic surgery |
| CN102805878A (en) * | 2012-08-29 | 2012-12-05 | 哈尔滨工程大学 | Medical degradable magnesium alloy meniscus suture line |
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