CN104510960A - Traditional Chinese medicinal tooth powder for inflammation preventing and pain easing - Google Patents
Traditional Chinese medicinal tooth powder for inflammation preventing and pain easing Download PDFInfo
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- CN104510960A CN104510960A CN201310709866.5A CN201310709866A CN104510960A CN 104510960 A CN104510960 A CN 104510960A CN 201310709866 A CN201310709866 A CN 201310709866A CN 104510960 A CN104510960 A CN 104510960A
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- extract
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- fructus alpiniae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
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Abstract
The invention discloses a traditional Chinese medicinal tooth powder for inflammation preventing and pain easing, and relates to the technical field of tooth powders. The tooth powder comprises 3-12wt% of compound traditional Chinese medicinal extract, 4-8wt% of pearl powder, 70-78wt% of calcium carbonate, 0.2-0.4wt% of carboxymethylcellulose sodium, 0.2-0.4wt% of sodium saccharin, 1.5-3wt% of sodium dodecyl sulfate, 0.5-1.5wt% of an essence, and the balance of sorbitol. The compound traditional Chinese medicinal extract comprises Dendrobium Stem extract, Callicarpa bodinieri extract and Fructus Alpiniae Oxyphyllae extract; and a raw medicine ratio of the Dendrobium Stem extract to the Callicarpa bodinieri extract to the Fructus Alpiniae Oxyphyllae extract is 5:3:3. The traditional Chinese medicinal tooth powder has substantial inflammation preventing and pain easing efficacies.
Description
Technical field
The present invention relates to dentifrice technical field, especially anti-inflammatory and antalgic Chinese medicine dentifrice.
Background technology
Dental caries, is commonly called as dental caries, decayed tooth, and refer to that dental tissue damages a kind of disease that disintegrate forms defect gradually, sickness rate is higher, and World Health Organization (WHO) needs the third-largest disease of keypoint control after being classified as cardiovascular diseases and cancer.In traditional preventing decayed tooth oral care product, as toothpaste, mainly add fluoride, but fluorine uses excessive, will cause fluorosis, gently then form dental fluorosis, heavy then cause skeletal fluorosis.In China, many areas are deeply by high Halothane gene, and fluorosis has become one of the most serious endemic illness of China's harm.And dentifrice is a kind of common oral cavity cleaning and nursing product, using method is identical with toothpaste, and most people have the custom of sooner or later brushing teeth, if the Chinese medicine with anti-inflammatory and antalgic can be combined with it, can medication prevention not need deliberately again.
Summary of the invention
The problem that the present invention solves is to provide a kind of dentifrice, and this dentifrice has effect of obvious anti-inflammatory and antalgic.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: the percentage by weight of its component is as follows:
Compound Chinese medicine extract 3%-12%; Margarita powder 4%-8%; Calcium carbonate 70%-78%; Sodium carboxymethyl cellulose 0.2%-0.4%; Saccharin sodium 0.2%-0.4%; Sodium lauryl sulphate 1.5%-3%; Essence 0.5%-1.5%; Sorbitol surplus;
Described compound Chinese medicine extract is golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract; Described white golden hairpin dendrobium extract: Folium Callicarpae Formosanae extract: the former medicine of Fructus Alpiniae Oxyphyllae extract is than being 5:3:3.
Dendrobium nobile of the present invention is perennial herb, for consumption of body fluid caused by febrile disease, thirsty dryness of the tongue, after being ill deficiency-heat, gastropathy, retch, the few tongue of tongue light.Have strengthen immunity, the beneficial essence of reinforcing YIN-essence, nourishing the stomach of promoting the production of body fluid, nourishing the lung to arrest cough, nourishing YIN and clearing away heat, promoting the production of body fluid to quench thirst, for consumption of body fluid caused by febrile disease, thirsty dryness of the tongue, after being ill deficiency-heat, anticancer, reinforcing stomach reg fluid, nourishing YIN and clearing away heat, liver heat removing, improving eyesight, adjusting blood lipid, blood sugar lowering etc.Special efficacy is had to cardiovascular and cerebrovascular vessel, digestive system and respiratory system, ophthalmology etc.
Folium Callicarpae Formosanae of the present invention, be belong to Verenaceae, Callicarpa perennial fast-growing shrub medical material, root, stem, leaf, flower, seed all can be used as medicine, and have heat-clearing and toxic substances removing, cooling blood for hemostasis, dephlogistication and promoting nuscle growth, the function such as anticancer; (" Fujian traditional herbal medicine ") is recorded, and controls postextraction hemorrhage more than, and available sterilization Cotton Gossypii dips in Folium Callicarpae Formosanae last plug; Folium Callicarpae Formosanae can make bleeding time and reduced clotting time, and its hemostasis principle may be that it makes vasoconstriction and platelet count is increased.
Fructus Alpiniae Oxyphyllae of the present invention, perennial herb, high 1-3m.Petiole is short; Blade lanceolar, long 20-30cm, wide 3-6cm, tip shape of tail is gradually sharp, the wide wedge shape of base portion, edge tool deciduous setula, and the residual trace of base is serration shape, and two sides is without hair; Containing abundant vitamin B group and vitamin C in Fructus Alpiniae Oxyphyllae, and trace element manganese, zinc, potassium, sodium, calcium, magnesium, phosphorus, ferrum and copper etc., show that Fructus Alpiniae Oxyphyllae has the multiple pharmacological effect such as antibacterial, antiinflammatory and analgesia.
Use with the form of Dendrobium nobile, Folium Callicarpae Formosanae and Fructus Alpiniae Oxyphyllae three taste compound Chinese medicine extract in the present invention, the extracting method of white golden hairpin dendrobium extract of the present invention, Folium Callicarpae Formosanae extract and Fructus Alpiniae Oxyphyllae extract is that every taste Chinese medicine is broken into fine powder, cross 150 mesh sieves, 3 hours are extracted with the alcohol heating reflux of 10 times amount, extract 3 times, then extracting solution concentrating under reduced pressure become extractum or be dried to powdery; Extracting method is not limited to said method, and the additive method such as supercritical extraction, ultrasonic extraction also can be adopted to extract.
Prove through overtesting, add using golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract as active ingredient of Chinese herbs in this dentifrice, to tooth, there is obvious anti-inflammatory and analgesic effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
Embodiment 1-5: containing Dendrobium nobile, Folium Callicarpae Formosanae and the Fructus Alpiniae Oxyphyllae dentifrice as compound Chinese medicine extract, white golden hairpin dendrobium extract: Folium Callicarpae Formosanae extract: the former medicine of Fructus Alpiniae Oxyphyllae extract is than being 5:3:3.
The dentifrice constitutive material of embodiment 1-5 and weight percent content are as following table:
clinical trial part:
(1)the antiinflammatory of white mice is tested:
Choose healthy Kun Ming mice 60, be divided into 6 groups at random, often organize 10, male and female half and half.Negative control group gives isopyknic distilled water, other group gives the concentrated solution in embodiment 1-5 prepared by compound Chinese medicine extract, during experiment, often organize two sides inside and outside every animal auris dextra corridor and all smear dimethylbenzene 0.1ml/ only to scorching, left ear does not add process and does self-blank matched group.After smearing dimethylbenzene 25min, often organize uniform application group tested material sample 0.1g/ respectively, two sides inside and outside every animal auris dextra corridor.After giving tested material 1h, the dislocation of white mice strength vertebra is put to death, and cuts two ear corridors, washes away auris dextra corridor tested material sample, clean with dry cotton ball with normal saline, and get two circle auricles with card punch at same position cutter, it is swelling value that auris dextra sheet weight deducts left auricle weight.
result:
Compare with blank group: * P<0.05, * * P<0.05, * * P<0.01, * * * * P<0.001, ▲ P>0.05.
conclusion:anti-inflammatory and antalgic Chinese medicine dentifrice contains golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract active additive, white mice acute inflammation swelling ear corridor quality can be made significantly to alleviate, white mice ear corridor acute inflammation swelling caused by obvious suppression dimethylbenzene, shows that anti-inflammatory and antalgic Chinese medicinal toothpaste has obvious antiinflammatory action to acute inflammation.
(2) to the analgesic test of white mice
Get Kun Ming mice 60, be divided into 6 groups at random, often organize ten, male and female half and half.Negative control group gives isopyknic distilled water, and other groups give the active additive of the dentifrice prepared by embodiment 1-5, and each dosage is 0.1g/, every day 1 time, for three days on end.After last administration, 30min concentration is the acetic acid normal saline 0.1ml on an empty stomach injection of 0.7%, observes the writhing number of times of white mice in 15min, and contrasts group difference.
Result:
**P<0.05.
Conclusion: the active additive containing golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract in this anti-inflammatory and antalgic Chinese medicine dentifrice obviously can reduce the writhing number of times produced after white mice watches analgesics attentively, has obvious analgesic activity.
Claims (1)
1. an anti-inflammatory and antalgic Chinese medicine dentifrice, is characterized in that the component comprising following percentage by weight:
Compound Chinese medicine extract 3%-12%; Margarita powder 4%-8%; Calcium carbonate 70%-78%; Sodium carboxymethyl cellulose 0.2%-0.4%; Saccharin sodium 0.2%-0.4%; Sodium lauryl sulphate 1.5%-3%; Essence 0.5%-1.5%; Sorbitol surplus;
Described compound Chinese medicine extract is golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract; Described white golden hairpin dendrobium extract: Folium Callicarpae Formosanae extract: the former medicine of Fructus Alpiniae Oxyphyllae extract is than being 5:3:3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310709866.5A CN104510960A (en) | 2013-12-21 | 2013-12-21 | Traditional Chinese medicinal tooth powder for inflammation preventing and pain easing |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310709866.5A CN104510960A (en) | 2013-12-21 | 2013-12-21 | Traditional Chinese medicinal tooth powder for inflammation preventing and pain easing |
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| CN104510960A true CN104510960A (en) | 2015-04-15 |
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| CN201310709866.5A Pending CN104510960A (en) | 2013-12-21 | 2013-12-21 | Traditional Chinese medicinal tooth powder for inflammation preventing and pain easing |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017166338A1 (en) * | 2016-03-29 | 2017-10-05 | 温雪峰 | Chinese herbal tooth powder |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244016A (en) * | 2008-03-17 | 2008-08-20 | 柳州两面针股份有限公司 | Application of aurantiin in preparing oral cavity nursing health products |
| CN102125513A (en) * | 2011-02-25 | 2011-07-20 | 海南黎药堂生物科技开发有限公司 | Oral health care product and preparation method thereof |
| CN102579988A (en) * | 2012-03-13 | 2012-07-18 | 常熟华港制药有限公司 | Traditional Chinese medicine for preventing and treating gingivitis, Chinese herbal medicine tooth powder and preparation method |
| CN102961318A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of compound traditional Chinese medicine extract in preparation of oral care health products |
-
2013
- 2013-12-21 CN CN201310709866.5A patent/CN104510960A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244016A (en) * | 2008-03-17 | 2008-08-20 | 柳州两面针股份有限公司 | Application of aurantiin in preparing oral cavity nursing health products |
| CN102125513A (en) * | 2011-02-25 | 2011-07-20 | 海南黎药堂生物科技开发有限公司 | Oral health care product and preparation method thereof |
| CN102579988A (en) * | 2012-03-13 | 2012-07-18 | 常熟华港制药有限公司 | Traditional Chinese medicine for preventing and treating gingivitis, Chinese herbal medicine tooth powder and preparation method |
| CN102961318A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of compound traditional Chinese medicine extract in preparation of oral care health products |
Non-Patent Citations (2)
| Title |
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| 何子乐 等: "《天然产物合成荟萃-生物碱》", 30 September 2009 * |
| 侯少贞 等: "铁皮石斛镇痛与抗炎作用研究", 《动物医学进展》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017166338A1 (en) * | 2016-03-29 | 2017-10-05 | 温雪峰 | Chinese herbal tooth powder |
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