CN104491772A - Preparation method of ointment dosage form for treating postpartum freckles - Google Patents

Preparation method of ointment dosage form for treating postpartum freckles Download PDF

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CN104491772A
CN104491772A CN201410677727.3A CN201410677727A CN104491772A CN 104491772 A CN104491772 A CN 104491772A CN 201410677727 A CN201410677727 A CN 201410677727A CN 104491772 A CN104491772 A CN 104491772A
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parts
radix
cream
corii asini
colla corii
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杨中明
梁剑萍
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LIYANG TIANMUHU DAZIWANG GRAPE SPECIALIZED COOPERATIVES
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LIYANG TIANMUHU DAZIWANG GRAPE SPECIALIZED COOPERATIVES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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Abstract

The invention relates to a preparation method of an ointment dosage form for treating postpartum freckles. The ointment-form traditional Chinese medicinal composition is prepared from the following medicinal raw materials, by weight, 5-30 parts of Chinese angelica, 3-20 parts of Ligusticum wallichii, 6-24 parts of the root bark of the peony tree, 3-18 parts of quick fried ginger, 3-20 parts of cassia twig, 5-20 parts of donkey-hide gelatin, 5-20 parts of white peony root, 10-30 parts of Radix Ophiopogonis, 5-20 parts of ginseng, 2-20 parts of licorice and 3-20 parts of radix bupleuri. The ointment composition also comprises 30-60 parts by weight of rock sugar. The preparation method of the ointment dosage form comprises the following steps: Step 1, immersion; Step 2, decoction; Step 3, concentration; Step 4, ointment forming; and Step 5, storage. After one treatment course, total effective rate reaches 90%.

Description

The cream prescription type preparation method for the treatment of freckle in puerperal
Technical field
The present invention relates to a kind of cream prescription type preparation method for the treatment of freckle in puerperal.Specifically, be preparation prepared by raw material with Chinese herbal medicine, belong to field of medicaments.
Background technology
Freckle is a kind of tiny speckle of pigmentation being common in face, and needle point is to grain of rice size, and circular or irregular shape, in filbert, brown or light black, smooth surface is without squama, and more or less for number, and density differs, and do not merge mutually.With face, particularly nasal region is common, also can be distributed in the places such as neck, arm, the back of the hand.Women is common, how to fall ill when childhood or teenager, and adolescence is the most obvious, alleviates gradually time old; Also women's postpartum onset person is had.Primary disease also without General Symptoms, can not bring physiological misery to patient, but concerning the vast women that likes to be beautiful, psychological pressure is self-evident.Modern medicine only adopts local application in treatment.Publication No. is that the Chinese invention patent application of CN 102755494 A discloses a kind of Chinese medicine composition for the treatment of freckle, said composition is made up of Rhizoma Dioscoreae, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Radix Rehmanniae, Poria, Cortex Lycii, Radix Paeoniae Rubra, Herba Artemisiae Annuae, Semen phaseoli radiati, Rhizoma Typhonii, the Radix Angelicae Dahuricae, Fructus Gleditsia, Herba Spirodelae, Fructus Psoraleae, the Radix Astragali, Talcum, Mel, and the present invention unlike this.
Summary of the invention
The object of the present invention is to provide a kind of cream prescription type preparation method for the treatment of freckle in puerperal:
Treat a cream prescription type preparation method for freckle in puerperal, the Chinese medicine composition of this cream prescription type is made up of the crude drug of following weight portion:
Radix Angelicae Sinensis 5 ~ 30 parts, Rhizoma Chuanxiong 3 ~ 20 parts, Cortex Moutan 6 ~ 24 parts, Rhizoma Zingiberis Preparatum 3 ~ 18 parts, Ramulus Cinnamomi 3 ~ 20 parts, 5 ~ 20 parts, Colla Corii Asini, the Radix Paeoniae Alba 5 ~ 20 parts, Radix Ophiopogonis 10 ~ 30 parts, Radix Ginseng 5 ~ 20 parts, 2 ~ 20 parts, Radix Glycyrrhizae, Radix Bupleuri 3 ~ 20 parts;
The crystal sugar of 30 ~ 60 parts of composition by weight is also comprised in the cream side of described compositions;
The preparation method of described cream prescription type is as follows:
The first step is soaked: component chooses above-mentioned high-quality medical material 11 taste by weight, all the other 9 herbal medicines except Colla Corii Asini and Radix Bupleuri are put into clean container jointly, adds appropriate water infiltration spice, make it fully absorb expansion, add water again after a while to exceed powder 12 cm, soak 18 hours; Radix Bupleuri soaks separately, Colla Corii Asini molten;
Second step decocts: the spice after soaking is got angry decoction; First boil with big fire, then boil 1 hours with little fire, receipts the first five minute of fire adds Radix Bupleuri, and go out slubbing medicine juice by filtered through gauze, clear water is decocted after infiltrating original medicinal residues again, and decoction is the same, repeats twice;
First three is decocted gained medicine juice and mix a place, sedimentation and filtration again after leaving standstill;
3rd step concentrates: filter clean medicine juice and pour in pot, first decoct with big fire, allow medicine juice slowly become stiff, then concentrate further with little fire, and constantly stir, and is stirred to medicine juice and drops in and paper do not scatter for degree;
4th step receives cream: crystal sugar and Colla Corii Asini are poured in clear paste, little fire is slowly tempered, constantly stirs, pull into flag until can pull or dripping into pearl; Drip into the determination methods of pearl for not faling apart condensing into pearl in cream juice instillation clear water;
5th step is deposited: after the cream cooling kept well, loads in clean clean porcelain container, does not first add a cover, and vessel port is hidden, place a night, after cooling completely, then add a cover with clean gauze, puts into shady and cool place.
Preferred: the composition by weight of the crude drug in the Chinese medicine composition of this cream prescription type is: Radix Angelicae Sinensis 10 ~ 24 parts, Rhizoma Chuanxiong 6 ~ 15 parts, Cortex Moutan 9 ~ 18 parts, Rhizoma Zingiberis Preparatum 6 ~ 15 parts, Ramulus Cinnamomi 5 ~ 15 parts, 9 ~ 15 parts, Colla Corii Asini, the Radix Paeoniae Alba 9 ~ 15 parts, Radix Ophiopogonis 15 ~ 24 parts, Radix Ginseng 9 ~ 15 parts, 4 ~ 15 parts, Radix Glycyrrhizae, Radix Bupleuri 6 ~ 15 parts.
Preferred: the composition by weight of the crude drug in the Chinese medicine composition of this cream prescription type is: Radix Angelicae Sinensis 15 parts, Rhizoma Chuanxiong 10 parts, Cortex Moutan 12 parts, Rhizoma Zingiberis Preparatum 9 parts, Ramulus Cinnamomi 10 parts, 10 parts, Colla Corii Asini, the Radix Paeoniae Alba 10 parts, Radix Ophiopogonis 15 parts, Radix Ginseng 10 parts, 10 parts, Radix Glycyrrhizae, Radix Bupleuri 10 parts.
The present invention selects 11 herbal medicines such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Moutan, Rhizoma Zingiberis Preparatum, Ramulus Cinnamomi, Colla Corii Asini, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Ginseng, Radix Glycyrrhizae, Radix Bupleuri to carry out prescription according to the principle of differentiation of tcm.Chinese medicine is thought, women's deficiency of qi and blood in puerperal, attacks outside cold-evil and the hyperamization liquid stasis of blood is stagnant, stagnation of blood stasis functional activity of QI being not smooth, and turbid yin cannot descending and spotting.
Radix Angelicae Sinensis Gan Xinwen in side, return liver heart spleen channel, enrich blood, invigorate blood circulation, pain relieving, intestine moistening; The pungent temperature of Rhizoma Chuanxiong, returns liver and gall pericardium channel, blood-activating and qi-promoting, wind-expelling pain-stopping; Cortex Moutan is bitter sweet to be slightly cold, GUIXIN Liver and kidney warp, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Three medicines share, and invigorate blood circulation and blood stasis dispelling.Rhizoma Zingiberis Preparatum is hot, returns spleen, stomach, kidney, the heart, lung meridian, warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding; Ramulus Cinnamomi Xin Ganwen, GUIXIN lung urinary bladder channel, relieving the exterior syndrome by diaphoresis, warming the meridian for promoting the flow of YANG QI; Two medicines share cold relieving and stimulate the menstrual flow, and blood obtains Wen Erhang.Colla Corii Asini is sweet flat, returns lung Liver and kidney warp, tonifying blood and arresting bleeding, nourishing YIN and moistening the lung; Radix Paeoniae Alba picric acid is slightly cold, and returns liver spleen channel, the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, suppressing liver-YANG; Two medicines share, and make that blood must be supported and heresy must be driven.Radix Ophiopogonis, sweet micro-hardship was slightly cold, and returned lung heart stomach warp, and nourishing lung-YIN, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness, the stasis of blood that purifies the blood and the heat caused.The micro-bitter tepor of ginseng sweet, returns spleen lung meridian, strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, increasing intelligence of calming the nerves; Radix Glycyrrhizae is sweet flat, GUIXIN lung spleen kidney channel, invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine; QI invigorating is to help blood.Radix Bupleuri toil is slightly cold, and the burnt gallbladder meridian of GUIXIN envelope liver three, reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, make lucid YANG getting to ascend and turbid yin must fall.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, such as: decoction, powder, pill, tablet, oral liquid, unguentum, capsule etc., the present invention preferably selects unguentum.
The present invention selects natural drug to be raw material, and each component meets pharmaceutical control law regulation.Utilize the comprehensive function treatment freckle in puerperal of each taste Chinese medicine, without chemical addition agent, harmless to human non-toxic.
Detailed description of the invention
Internal composition takes raw material (kilogram) by following proportioning
1, Radix Angelicae Sinensis 5, Rhizoma Chuanxiong 3, Cortex Moutan 6, Rhizoma Zingiberis Preparatum 3, Ramulus Cinnamomi 3, Colla Corii Asini 5, the Radix Paeoniae Alba 5, Radix Ophiopogonis 10, Radix Ginseng 5, Radix Glycyrrhizae 2, Radix Bupleuri 3;
2, Radix Angelicae Sinensis 30, Rhizoma Chuanxiong 20, Cortex Moutan 24, Rhizoma Zingiberis Preparatum 18, Ramulus Cinnamomi 20, Colla Corii Asini 20, the Radix Paeoniae Alba 20, Radix Ophiopogonis 30, Radix Ginseng 20, Radix Glycyrrhizae 20, Radix Bupleuri 20;
3, Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 6, Cortex Moutan 9, Rhizoma Zingiberis Preparatum 6, Ramulus Cinnamomi 5, Colla Corii Asini 9, the Radix Paeoniae Alba 9, Radix Ophiopogonis 15, Radix Ginseng 9, Radix Glycyrrhizae 4, Radix Bupleuri 6;
4, Radix Angelicae Sinensis 24, Rhizoma Chuanxiong 15, Cortex Moutan 18, Rhizoma Zingiberis Preparatum 15, Ramulus Cinnamomi 15, Colla Corii Asini 15, the Radix Paeoniae Alba 15, Radix Ophiopogonis 24, Radix Ginseng 15, Radix Glycyrrhizae 15, Radix Bupleuri 15;
5, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 10, Cortex Moutan 12, Rhizoma Zingiberis Preparatum 9, Ramulus Cinnamomi 10, Colla Corii Asini 10, the Radix Paeoniae Alba 10, Radix Ophiopogonis 15, Radix Ginseng 10, Radix Glycyrrhizae 10, Radix Bupleuri 10.
Production method is as follows:
The first step is soaked: component chooses above-mentioned high-quality medical material 11 taste by weight, all the other 9 herbal medicines except Colla Corii Asini and Radix Bupleuri are put into clean container jointly, adds appropriate water infiltration spice, make it fully absorb expansion, add water again after a while to exceed powder 12 cm, soak 18 hours; Radix Bupleuri soaks separately, Colla Corii Asini molten.
Second step decocts: the spice after soaking is got angry decoction.First boil with big fire, then boil 1 hours with little fire, receipts the first five minute of fire adds Radix Bupleuri, and go out slubbing medicine juice by filtered through gauze, clear water is decocted after infiltrating original medicinal residues again, and decoction is the same, repeats twice.First three is decocted gained medicine juice and mix a place, sedimentation and filtration again after leaving standstill.
3rd step concentrates: filter clean medicine juice and pour in pot, first decoct with big fire, allow medicine juice slowly become stiff, then concentrate further with little fire, and constantly stir, and is stirred to medicine juice and drops in and paper do not scatter for degree.
4th step receives cream: crystal sugar and Colla Corii Asini are poured in clear paste, little fire is slowly tempered, constantly stirs, and pulls into flag until can pull or is dripping into pearl (not faling apart condensing into pearl in cream juice instillation clear water).
5th step is deposited: after the cream cooling kept well, loads in clean clean porcelain container, does not first add a cover, and vessel port is hidden, place a night, after cooling completely, then add a cover with clean gauze, puts into shady and cool place.
For verifying the therapeutic effect of this Chinese medicine composition to freckle in puerperal, the present invention have passed through 10 routine system clinical observations: patient women, and the age, 25 ~ 37, occurs freckle all after manufacture, and time medical, the course of disease 13 ~ 20 months is not etc.Patients is: menstrual cycle is normal, but Hypomenorrhea color secretly has clot, red tongue with thin fur stringy and thready pulse.
Instructions of taking: adopt the Chinese medicine in embodiment 5, make cream side, twice daily, each 9 grams three months is a course for the treatment of.Belong to the first behavior child wean of patient, regulating spirit and emotion by oneself, light diet, few Exposure to Sunlight.
Result
After the course for the treatment of, freckle is disappearance person 6 example completely, and obvious minimizing person 3 example, has no significant change person 1 example, total effective rate 90%.

Claims (3)

1. treat a cream prescription type preparation method for freckle in puerperal, it is characterized in that the Chinese medicine composition of this cream prescription type is made up of the crude drug of following weight portion:
Radix Angelicae Sinensis 5 ~ 30 parts, Rhizoma Chuanxiong 3 ~ 20 parts, Cortex Moutan 6 ~ 24 parts, Rhizoma Zingiberis Preparatum 3 ~ 18 parts, Ramulus Cinnamomi 3 ~ 20 parts, 5 ~ 20 parts, Colla Corii Asini, the Radix Paeoniae Alba 5 ~ 20 parts, Radix Ophiopogonis 10 ~ 30 parts, Radix Ginseng 5 ~ 20 parts, 2 ~ 20 parts, Radix Glycyrrhizae, Radix Bupleuri 3 ~ 20 parts;
The crystal sugar of 30 ~ 60 parts of composition by weight is also comprised in the cream side of described compositions;
The preparation method of described cream prescription type is as follows:
The first step is soaked: component chooses above-mentioned high-quality medical material 11 taste by weight, all the other 9 herbal medicines except Colla Corii Asini and Radix Bupleuri are put into clean container jointly, adds appropriate water infiltration spice, make it fully absorb expansion, add water again after a while to exceed powder 12 cm, soak 18 hours; Radix Bupleuri soaks separately, Colla Corii Asini molten;
Second step decocts: the spice after soaking is got angry decoction; First boil with big fire, then boil 1 hours with little fire, receipts the first five minute of fire adds Radix Bupleuri, and go out slubbing medicine juice by filtered through gauze, clear water is decocted after infiltrating original medicinal residues again, and decoction is the same, repeats twice;
First three is decocted gained medicine juice and mix a place, sedimentation and filtration again after leaving standstill;
3rd step concentrates: filter clean medicine juice and pour in pot, first decoct with big fire, allow medicine juice slowly become stiff, then concentrate further with little fire, and constantly stir, and is stirred to medicine juice and drops in and paper do not scatter for degree;
4th step receives cream: crystal sugar and Colla Corii Asini are poured in clear paste, little fire is slowly tempered, constantly stirs, pull into flag until can pull or dripping into pearl; Drip into the determination methods of pearl for not faling apart condensing into pearl in cream juice instillation clear water;
5th step is deposited: after the cream cooling kept well, loads in clean clean porcelain container, does not first add a cover, and vessel port is hidden, place a night, after cooling completely, then add a cover with clean gauze, puts into shady and cool place.
2. the cream prescription type preparation method for the treatment of freckle in puerperal according to claim 1, is characterized in that the composition by weight of the crude drug in the Chinese medicine composition of this cream prescription type is: Radix Angelicae Sinensis 10 ~ 24 parts, Rhizoma Chuanxiong 6 ~ 15 parts, Cortex Moutan 9 ~ 18 parts, Rhizoma Zingiberis Preparatum 6 ~ 15 parts, Ramulus Cinnamomi 5 ~ 15 parts, 9 ~ 15 parts, Colla Corii Asini, the Radix Paeoniae Alba 9 ~ 15 parts, Radix Ophiopogonis 15 ~ 24 parts, Radix Ginseng 9 ~ 15 parts, 4 ~ 15 parts, Radix Glycyrrhizae, Radix Bupleuri 6 ~ 15 parts.
3. the cream prescription type preparation method for the treatment of freckle in puerperal according to claim 1, is characterized in that the composition by weight of the crude drug in the Chinese medicine composition of this cream prescription type is: Radix Angelicae Sinensis 15 parts, Rhizoma Chuanxiong 10 parts, Cortex Moutan 12 parts, Rhizoma Zingiberis Preparatum 9 parts, Ramulus Cinnamomi 10 parts, 10 parts, Colla Corii Asini, the Radix Paeoniae Alba 10 parts, Radix Ophiopogonis 15 parts, Radix Ginseng 10 parts, 10 parts, Radix Glycyrrhizae, Radix Bupleuri 10 parts.
CN201410677727.3A 2014-11-23 2014-11-23 Preparation method of ointment dosage form for treating postpartum freckles Pending CN104491772A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107115257A (en) * 2017-05-04 2017-09-01 王灵芝 A kind of beautifying donkey-hide gelatin applies cream preparation method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘丽伟等: "《金匮要略》温经汤临床应用心得", 《中国中医药现代远程教育》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107115257A (en) * 2017-05-04 2017-09-01 王灵芝 A kind of beautifying donkey-hide gelatin applies cream preparation method

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Application publication date: 20150408