CN104491684B - A kind of Chinese medicine for treating insomnia and its application - Google Patents
A kind of Chinese medicine for treating insomnia and its application Download PDFInfo
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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Abstract
The present invention relates to a kind of Chinese medicine for treating insomnia and its application, described Chinese medicine is made up of the bulk drug of following parts by weight：18 22 parts of lycopodium calvatum, 8 12 parts of lopseed, 8 12 parts of Radix Angelicae Sinensis, 48 parts of safflower, 18 22 parts of root tuber of aromatic turmeric, it also can further include 18 22 parts of Polygonum multiflower knotweed, 8 12 parts of cortex albiziae, 5 12 parts of fushen.The drug matching of the present invention is precise and appropriate, calmness, the significant effect calmed the nerves, promote dormancy, and is externally applied drug, no dependence, will not damage body, security is good, while flavour of a drug number is few, is easy to prepare, cost is low.
Description
【Technical field】
It is one kind using Chinese herbal medicine as raw material system specifically the present invention relates to a kind of Chinese medicine for treating insomnia and its application
Standby Chinese patent drug.
【Background technology】
With society it is growing, many people study, work and life etc. it is all many-side on there is huge pressure
Power, it is tired out, absent-minded to directly result in their bodies, so as to trigger difficulty falling asleep, insomnia etc..Difficulty falling asleep, insomnia are health
Formidable enemy, to cause enough attention, think many human factor errors vigilance disorders do not interfere with the health of people and delay treatment, very not
Know that chronic insomnia can cause brain dysfunction, a variety of harm are caused to body, insomnia has a strong impact on physical and mental health, main performance
For：(1) body immunity declines, and the resistance of various diseases is weakened；(2) chronic insomnia can trigger hypertension, heart disease, height
Blood fat, senile dementia；(3) failure of memory, headache, feels dizzy, tinnitus is forgetful, neurasthenia etc.；(4) influence work,
Studying and living, insomnia often lead to lassitude on daytime, and operating efficiency is low, nervous irritability, gets along inharmonious with people around, suppression
Strongly fragrant, unhappy, serious also resulting in is pessimistic and worldweary.
According to investigations, China insomniac there are about 1.5 hundred million at present, and dyssomnia person is up to 300,000,000 people, wherein more than 200,000,000 live
In city.In adult, about 50% has the experience of dyssomnia, and more has up to 80% people in working women by dyssomnia
Perplex, by the also quite a lot of this puzzlement in the elderly, the problem of healthy of sleeping is increasingly subject to the concern of people.
Insomnia generally requires Long-term taking medicine, but long-term use of some Western medicine such as barbiturates, benzene two as stubborn disease
Nitrogen Zhuo class can produce serious dependence, take how much Chinese medicine also has some toxic side effects, and externally applied drug then can be by toxic side effect
Minimize.
Chinese patent literature CN201110262930.0, publication date 2012.01.11, disclose in a kind of sleeping of external application
Medicine preparation, it is made up of main pharmacodynamics composition and auxiliary material, its main pharmacodynamics composition has following component：Ginseng, the Radix Astragali, Radix Angelicae Sinensis, the five tastes
Son, grass-leaved sweetflag and polygala.Chinese patent literature CN201010205073.6, publication date 2010.10.13, disclose a kind for the treatment of
The external medicine composition of insomnia, its composition being formulated and mass ratio are：Polygonum multiflower knotweed, Flos Albiziae, polygala, mother-of-pearl, the fruit of glossy privet
With the coptis 6: 6: 6: 5: 5: 2, the Chinese medicine composition is theoretical with Traditional Chinese Medicine acupoint therapy and modern pharmacy Transdermal absorption, this
External medicine composition is ground into powder, adds yellow rice wine to mix well into pasty state, spreads on human body bilateral Sanyinjiao, spring, Zhaohai, interior pass
Cave.
However, the medicine for developing the treatment insomnia of more remarkable treatment effect is still very necessary.
【The content of the invention】
The purpose of the present invention is to be directed to deficiency of the prior art, there is provided a kind of Chinese medicine composition for treating insomnia.
Another purpose of the present invention is to provide the purposes of described Chinese medicine composition.
To achieve the above object, the present invention adopts the technical scheme that：
As the present invention a kind of scheme, a kind of Chinese medicine composition for treating insomnia, it by following parts by weight bulk drug
It is made：Lycopodium calvatum 18-22 parts, lopseed 8-12 parts, Radix Angelicae Sinensis 8-12 parts, safflower 4-8 parts, root tuber of aromatic turmeric 18-22 parts.
Preferably, described Chinese medicine composition is made up of the bulk drug of following parts by weight：20 parts of lycopodium calvatum, lopseed 10
Part, 10 parts of Radix Angelicae Sinensis, 6 parts of safflower, 20 parts of root tuber of aromatic turmeric.
As the present invention another scheme, a kind of Chinese medicine composition for treating insomnia, it by following parts by weight raw material
Medicine is made：Lycopodium calvatum 18-22 parts, lopseed 8-12 parts, Radix Angelicae Sinensis 8-12 parts, safflower 4-8 parts, root tuber of aromatic turmeric 18-22 parts, Polygonum multiflower knotweed 18-
22 parts, cortex albiziae 8-12 parts, fushen's 5-12 parts.
Preferably, described Chinese medicine composition is made up of the bulk drug of following parts by weight：20 parts of lycopodium calvatum, lopseed 10
Part, 10 parts of Radix Angelicae Sinensis, 6 parts of safflower, 20 parts of root tuber of aromatic turmeric, 20 parts of Polygonum multiflower knotweed, 10 parts of cortex albiziae, 10 parts of fushen.
The formulation of described Chinese medicine composition is lotion or granule.
To realize above-mentioned second purpose, the present invention adopts the technical scheme that：
As above application of any described Chinese medicine composition in the medicine for preparing treatment insomnia.
The invention has the advantages that：
1st, Chinese medicine composition compatibility of the invention is precise and appropriate, calmness, the significant effect calmed the nerves, promote dormancy；
2nd, Chinese medicine composition of the invention is externally applied drug, and no dependence will not damage body, and security is good；
3rd, flavour of a drug number is few, is easy to prepare, cost is low.
【Embodiment】
Embodiment provided by the invention is elaborated below.
The preparation (one) of the Chinese medicine composition one of the present invention of embodiment 1
20 parts of lycopodium calvatum, 10 parts of lopseed, 10 parts of Radix Angelicae Sinensis, 6 parts of safflower, 20 parts of root tuber of aromatic turmeric, conventional method decoct.
The preparation (two) of the Chinese medicine composition one of the present invention of embodiment 2
18 parts of lycopodium calvatum, 12 parts of lopseed, 8 parts of Radix Angelicae Sinensis, 8 parts of safflower, 18 parts of root tuber of aromatic turmeric, conventional method decoct.
The preparation (three) of the Chinese medicine composition one of the present invention of embodiment 3
22 parts of lycopodium calvatum, 8 parts of lopseed, 12 parts of Radix Angelicae Sinensis, 4 parts of safflower, 22 parts of root tuber of aromatic turmeric, conventional method decoct.
The preparation (four) of the Chinese medicine composition one of the present invention of embodiment 4
22 parts of lycopodium calvatum, 12 parts of lopseed, 8 parts of Radix Angelicae Sinensis, 4 parts of safflower, 22 parts of root tuber of aromatic turmeric, conventional method decoct.
The preparation (five) of the Chinese medicine composition one of the present invention of embodiment 5
18 parts of lycopodium calvatum, 8 parts of lopseed, 12 parts of Radix Angelicae Sinensis, 8 parts of safflower, 18 parts of root tuber of aromatic turmeric, conventional method decoct.
The preparation (six) of the Chinese medicine composition one of the present invention of embodiment 6
18 parts of lycopodium calvatum, 8 parts of lopseed, 8 parts of Radix Angelicae Sinensis, 8 parts of safflower, 22 parts of root tuber of aromatic turmeric, conventional method decoct.
The preparation (one) of the Chinese medicine composition two of the present invention of embodiment 7
20 parts of lycopodium calvatum, 10 parts of lopseed, 10 parts of Radix Angelicae Sinensis, 6 parts of safflower, 20 parts of root tuber of aromatic turmeric, 20 parts of Polygonum multiflower knotweed, cortex albiziae 10
Part, 10 parts of fushen, conventional method decoct.
The preparation (two) of the Chinese medicine composition two of the present invention of embodiment 8
18 parts of lycopodium calvatum, 12 parts of lopseed, 8 parts of Radix Angelicae Sinensis, 8 parts of safflower, 18 parts of root tuber of aromatic turmeric, 22 parts of Polygonum multiflower knotweed, 8 parts of cortex albiziae,
12 parts of fushen, conventional method decoct.
The preparation (three) of the Chinese medicine composition two of the present invention of embodiment 9
22 parts of lycopodium calvatum, 12 parts of lopseed, 8 parts of Radix Angelicae Sinensis, 4 parts of safflower, 22 parts of root tuber of aromatic turmeric, 22 parts of Polygonum multiflower knotweed, 8 parts of cortex albiziae,
5 parts of fushen, conventional method decoct.
The preparation (four) of the Chinese medicine composition two of the present invention of embodiment 10
22 parts of lycopodium calvatum, 8 parts of lopseed, 12 parts of Radix Angelicae Sinensis, 4 parts of safflower, 22 parts of root tuber of aromatic turmeric, 18 parts of Polygonum multiflower knotweed, 12 parts of cortex albiziae,
5 parts of fushen, conventional method decoct.
The preparation (five) of the Chinese medicine composition two of the present invention of embodiment 11
18 parts of lycopodium calvatum, 8 parts of lopseed, 8 parts of Radix Angelicae Sinensis, 8 parts of safflower, 22 parts of root tuber of aromatic turmeric, 22 parts of Polygonum multiflower knotweed, 12 parts of cortex albiziae,
12 parts of fushen, conventional method decoct.
The preparation (six) of the Chinese medicine composition two of the present invention of embodiment 12
22 parts of lycopodium calvatum, 8 parts of lopseed, 8 parts of Radix Angelicae Sinensis, 8 parts of safflower, 22 parts of root tuber of aromatic turmeric, 22 parts of Polygonum multiflower knotweed, 8 parts of cortex albiziae, Fu
12 parts of god, conventional method decoct.
The preparation of 13 Chinese medicinal composition granules of the present invention of embodiment
Any described raw medicinal materials of Example 1-12, add 8-10 times to measure water, decoct 2.5-3.5 hours, filter out concoction.
Again plus 10 times are measured water, are decocted 2 hours, are filtered out concoction, merge secondary decocting liquid, stand, leaching supernatant, concentration, let cool, enriching contracting
2 times of amount alcohol of liquid, stir precipitates overnight.Supernatant is taken, is concentrated into thick medicinal extract；Add appropriate pharmaceutical aids, pelletize, dry, whole grain,
20g particles are obtained, dispense 10g/ bags.
The clinical test of 14 Chinese medicine composition of the present invention of embodiment
1st, the standard of case is selected
Insomnia refers to the sleep state that can not fall asleep or can not keep, and causes to have not enough sleep.Also known as fall asleep and maintain sleep to hinder
Hinder (DlMS), cause difficulty falling asleep, Depth of sleep or frequency be too short, early awakening and the length of one's sleep insufficient or of poor quality for a variety of causes
Deng being a kind of common disease.Insomnia often brings greatly pain and psychological burden to patient.Clinical manifestation is night awakening time
Number is more than 2 times or morning early awakening；Sleep quality：Dreaminess；Total sleep time is less than 6 hours；In the daytime residual effect：Secondary morning feels head
Dusk, lassitude, drowsiness, weak etc..By the course of disease point：Transient or acute insomnia；The course of disease is less than 4 weeks persons for slight insomnia.
2nd, diagnostic criteria
Doctor trained in Western medicine diagnosis is examined according to the diagnostic criteria about insomnia in " Chinese Spirit Obstacles classification and diagnostic criteria ", the traditional Chinese medical science
The disconnected diagnostic criteria with reference in " disease of tcm controversial issue criterion of therapeutical effect " on being insomnia.The lighter's difficulty falling asleep and benefit wake up, wake up after be difficult to
Fall asleep again, continuous more than 2 weeks；Often with dizziness, headache, palpitaition, forgetful, dreaminess etc.；Organic disease is there are no, has no laboratory
The exception of inspection.Slight insomnia is not all to occur daily, spiritedness pressure, it is overstrain one's nerves when just appearance；Sleep is less than 6 hours,
The course of disease is less than 4 weeks.There can be the situation that interruption ensures sleep using hypnotic on a small quantity, but hypnotic can not be relied on.
3rd, therapeutic scheme
One group of Chinese medicine of the present invention：The lotion prepared using embodiment 1 is foamed foot, lotion concentration be 10g bulk drugs crude drug/liter
Water, about 35~40 DEG C of temperature, evening 9-10 points (sleeping first 1 hour) foam foot 30~40 minutes, one time a day, are used in conjunction 1 week as 1 treatment
Journey.
Two groups of Chinese medicine of the present invention：The lotion prepared using embodiment 7 is foamed foot, lotion concentration be 10g bulk drugs crude drug/liter
Water, about 35~40 DEG C of temperature, evening 9-10 points (sleeping first 1 hour) foam foot 30~40 minutes, one time a day, are used in conjunction 1 week as 1 treatment
Journey.
Compare one group：The lotion prepared using following Chinese medicine composition is foamed foot, and Chinese medicine composition is：It is 20 parts of lycopodium calvatum, deep
10 parts of grass, 10 parts of Radix Angelicae Sinensis, 6 parts of safflower, 20 parts of Ligusticum wallichii, lotion concentration are 10g bulk drugs crude drug/liter water, about 35~40 DEG C of temperature,
Evening 9-10 points (sleeping first 1 hour) foam foot 30~40 minutes, and one time a day, it is 1 course for the treatment of to be used in conjunction 1 week.
Compare two groups：The lotion prepared using following Chinese medicine composition is foamed foot, and Chinese medicine composition is：It is 20 parts of lycopodium calvatum, deep
10 parts of grass, 10 parts of root tuber of aromatic turmeric, 6 parts of safflower, 20 parts of Radix Angelicae Sinensis, 20 parts of Polygonum multiflower knotweed, 10 parts of cortex albiziae, 10 parts of fushen, lotion concentration is 10g
Bulk drug crude drug/liter water, about 35~40 DEG C of temperature, evening 9-10 points (sleeping first 1 hour) are foamed foot 30~40 minutes, one time a day, connected
It was 1 course for the treatment of with 1 week.
Compare three groups：The blistering foot that about 35~40 DEG C of temperature in use, evening 9-10 points (sleeping first 1 hour) foam foot 30~40 minutes
Clock, one time a day, it is 1 course for the treatment of to be used in conjunction 1 week.
Sit quietly or lie down after foaming foot, set aside all worries, pay attention to warming.2 courses for the treatment of are observed altogether.
4th, efficacy assessment standard
Clinical recovery：The length of one's sleep recovers normal after treatment or the length of one's sleep is more than 6 hours, and the cardinal symptom to occur together disappears
Lose；
Effectively：Total sleep time extends more than 2 hours before relatively treating, and the symptom to occur together is improved；
It is invalid：Sleep extends less than 2 hours without improvement, or the length of one's sleep after treatment, and concomitant symptom is not improved.
5th, statistical procedures
Counted using SPSS13.0 software processings.
6th, result
According to above-mentioned diagnostic criteria and therapeutic scheme, 200 patients are chosen altogether, are randomly divided into 5 groups, age between each group,
More not statistically significant (the P of sex, the course of disease>0.05).Efficacy evaluation is carried out after 2 courses for the treatment of of treatment, the results are shown in Table 1.Statistics
Analysis shows, two groups of one group of Chinese medicine, two groups of Chinese medicine of the present invention, one group of control and control of the present invention are respectively compared with compareing three groups,
It can significantly mitigate insomnia (P<0.05)；One group of Chinese medicine of the present invention is distinguished with compareing the total effective rate of one group and two groups of control
Compare, be respectively provided with statistical significance (P<0.05)；Total effective rate point of two groups of the Chinese medicine of the present invention with compareing one group and two groups of control
Do not compare, be also respectively provided with statistical significance (P<0.05)；Two groups of effects of Chinese medicine of the present invention are better than one group of (P of Chinese medicine of the present invention<
0.05)。
Each group treatment results after 12 courses for the treatment of of table
| N (example) | Fully recover (example) | Effectively (example) | Invalid (example) | Total effective rate | |
| One group of Chinese medicine of the present invention | 40 | 27 | 8 | 5 | 87.5% |
| Two groups of Chinese medicine of the present invention | 40 | 31 | 9 | 0 | 100% |
| Compare one group | 40 | 14 | 13 | 13 | 67.5% |
| Compare two groups | 40 | 15 | 14 | 11 | 72.5% |
| Compare three groups | 40 | 3 | 8 | 29 | 27.5% |
7th, conclusion
Above-mentioned experiment fully proves that Chinese medicine composition of the invention has the effect of significant tranquilizing and allaying excitement, treatment insomnia,
And due to being topical administration, therefore have no toxic side effect, drug safety, curative effect stabilization.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the inventive method is not departed from, can also make some improvement and supplement, and these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (6)
1. a kind of Chinese medicine composition for treating insomnia, it is characterised in that it is made up of the bulk drug of following parts by weight：Lycopodium calvatum
18-22 parts, lopseed 8-12 parts, Radix Angelicae Sinensis 8-12 parts, safflower 4-8 parts, root tuber of aromatic turmeric 18-22 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that it is made up of the bulk drug of following parts by weight：Stretch
20 parts of muscle grass, 10 parts of lopseed, 10 parts of Radix Angelicae Sinensis, 6 parts of safflower, 20 parts of root tuber of aromatic turmeric.
3. a kind of Chinese medicine composition for treating insomnia, it is characterised in that it is made up of the bulk drug of following parts by weight：Lycopodium calvatum
18-22 parts, lopseed 8-12 parts, Radix Angelicae Sinensis 8-12 parts, safflower 4-8 parts, root tuber of aromatic turmeric 18-22 parts, Polygonum multiflower knotweed 18-22 parts, cortex albiziae 8-
12 parts, fushen's 5-12 parts.
4. Chinese medicine composition according to claim 3, it is characterised in that it is made up of the bulk drug of following parts by weight：Stretch
20 parts of muscle grass, 10 parts of lopseed, 10 parts of Radix Angelicae Sinensis, 6 parts of safflower, 20 parts of root tuber of aromatic turmeric, 20 parts of Polygonum multiflower knotweed, 10 parts of cortex albiziae, 10 parts of fushen.
5. according to any described Chinese medicine compositions of claim 1-4, it is characterised in that the formulation of described Chinese medicine composition is
Lotion or granule.
6. application of any described Chinese medicine compositions of claim 1-4 in the medicine for preparing treatment insomnia.
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| CN106728279A (en) * | 2017-01-10 | 2017-05-31 | 王园园 | A kind of foot bath Traditional Chinese drug mixture |
| CN107468995A (en) * | 2017-08-11 | 2017-12-15 | 淮南健科足疗用品有限公司 | Depressed shoe-pad is controlled in Chinese medicine sleeping compound preparation and sleeping |
| CN115645505B (en) * | 2022-10-10 | 2023-09-19 | 上海市中医医院 | Traditional Chinese medicine composition for relieving pre-operative anxiety and sleep disorder of hemorrhoids and application thereof |
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