CN104490905B - A kind of emulsifiable paste and preparation method for being used to treat hemorrhoid - Google Patents
A kind of emulsifiable paste and preparation method for being used to treat hemorrhoid Download PDFInfo
- Publication number
- CN104490905B CN104490905B CN201410691311.7A CN201410691311A CN104490905B CN 104490905 B CN104490905 B CN 104490905B CN 201410691311 A CN201410691311 A CN 201410691311A CN 104490905 B CN104490905 B CN 104490905B
- Authority
- CN
- China
- Prior art keywords
- emulsifiable paste
- stand
- tristerin
- atoleine
- azone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
A kind of emulsifiable paste for being used to treat hemorrhoid, is related to pharmaceutical technology field, the medicament being formulated by following bulk drug：The 1.5g of Triamcinolone acetonide 0.5, the 10g of neomycinsulphate 4, the 12g of miconazole nitrate 8, the 200g of stearic acid 100, the 100g of tristerin 50, the 70ml of atoleine 40, the 100ml of propane diols 50, the 1ml of azone 0.1, the 1.5g of ethylparaben 0.5, the 800ml of distilled water 500；Compound method of the present invention is simple, with rapid-action, cure rate height, the advantages of uneasy to recur.
Description
Technical field
The present invention relates to pharmaceutical technology field, and in particular to a kind of emulsifiable paste and preparation method for being used to treat hemorrhoid.
Background technology
Hemorrhoid are the distinctive common disease of the mankind, frequently-occurring disease.Show according to relevant reconnaissance information, the incidence of disease of anorectal disease
For 59.1%, hemorrhoid account in all anorectal diseases 87.25%, it is and wherein most commonly seen with internal piles, account for all anorectal diseases
52.19%.Men and women can fall ill, and the incidence of disease of women is 67%, and the incidence of disease of male is 53.9%；Any age can all be sent out
Disease, the wherein people of 20-40 Sui is more common, and aggravates with advancing age and gradually, therefore it is said that nine out ten suffer from hemorrhoids.Hemorrhoid
The normal life that the lighter gives people is made troubles；Severe one is unhealthful.Such as have blood in stool with the passing of time, different degrees of anaemia can be caused, or even go out
Courage and uprightness shock, threat to life；When hemorrhoid necrosis, infection are serious, general infection can be caused by hematological system, consequence is serious.
Because hemorrhoid are generated by hemorrhoidal veins varicose extravasated blood, and intestines poison, Escherichia coli, staphylococcus aureus, yeast
The bacterium such as bacterium, they interact, and make the normal absorption function imbalance of human rectum, and system of defense is disorderly, produces inflammation, makes straight
Intestines, anus life sore, redness, pain, prolapse of the anus, anal fissure etc..Research finds that medical treatment hemorrhoid are mostly with oral or instillation antibiosis
Element, coordinates external medication, and does not have Tri-Biocin in these external used medicines, it is impossible to through focus, therefore effect is not
It is very good.
The content of the invention
The technical problems to be solved by the invention are to provide that a kind of cure rate is high, safe and reliable to be used to treat hemorrhoid
The emulsifiable paste of sore, success is used to antibiotic and glucocorticoid medicine treat hemorrhoid, and prepares simple, property stabilization.
The technical problems to be solved by the invention are realized using following technical scheme：
A kind of emulsifiable paste for being used to treat hemorrhoid, the medicament being formulated by following bulk drug：Triamcinolone acetonide 0.5-1.5g,
Neomycinsulphate 4-10g, miconazole nitrate 8-12g, stearic acid 100-200g, tristerin 50-100g, atoleine
40-70ml, propane diols 50-100ml, azone 0.1-1ml, ethylparaben 0.5-1.5g, distilled water 500-800ml；
The optimum ratio of each bulk drug is：Triamcinolone acetonide 1g, neomycinsulphate 7g, miconazole nitrate 10g, stearic acid
130g, tristerin 70g, atoleine 50ml, propane diols 80ml, azone 0.5ml, ethylparaben 1g, distilled water are (pure
Water purification) 650ml；
Bulk drug used in the present invention can be commercially available from common Chinese shop, and its specification meets the national drug standards i.e.
Can.
It is a further object to provide a kind of method for preparing above-mentioned emulsifiable paste, comprise the following steps,
1) to weigh each bulk drug by above-mentioned prescription stand-by；
2) by Triamcinolone acetonide, neomycinsulphate, miconazole nitrate grinds to form powdery, obtains granular material stand-by；
3) stearic acid is taken, tristerin, atoleine is put into container, heating water bath, and temperature control is in 70-80
DEG C, stirring is molten into oily mater, stand-by；
4) another taking ethylparaben stirs with propane diols, is added in the lump in 70-80 DEG C of distilled water in azone, stirs
Uniformly, aqueous mixture is obtained, it is stand-by；
5) by step 3) in oily mater be slowly added into step 4) in aqueous mixture in, do not stop stirring, treat temperature
Step 2 is added when degree is down to 60 DEG C) in granular material, stir.
Pharmacology analysis：
Triamcinolone acetonide：Sugar skin hormone class medicine, white crystalline powder is odorless, have antipruritic, anti-inflammatory, anti-allergic effects；We
In be used as treatment anus redness, sufferings etc..
Neomycinsulphate：White powder, to the gram- bacteria such as saccharomycete, there is antibacterial action in race；Make anti-inflammatory, antibacterial in we
Effect, it is effective to bacterium such as intestines poison, staphylococcus aureuses；
Miconazole nitrate：White crystalline powder, it is odorless, have antifungic action.
Stearic acid：The glossiness wax-like small pieces of white, it is soft, nontoxic, it is a kind of higher unsaturated fatty acid, is emulsified in we
Agent, inserts.
Tristerin：White or pale waxy solid, have and make emulsifying agent, profit in the fat note of smelling good, we
Lubrication prescription.
Atoleine：Colourless viscous liquid, it is odorless, tasteless, make emulsifying agent.
Propane diols：Colourless transparent liquid, has and makees to inhale smelly, lubrication in hygroscopicity, we.
Azone：Oiliness colourless transparent liquid, we make bleeding agent and help medicine to enter focus quickly.
Ethylparaben：White crystalline powder, there is slight fragrance, and bitter, to photosynthetic thermally-stabilised, resists in we
Bacterium, antisepsis, are dissolved in propane diols.
Distilled water：Diluent in we.
Usage and consumption：
Clean, 1 gram or so of medication, be sent into anus, once a day after an action of the bowels daily；Navel is massaged into absorption, daily 2 a little
It is secondary.
Points for attention：
1. diet is preferably light, give up alcohol and pungent, raw and cold, greasy food.
2. children, women breast-feeding their children, elderly and infirm should take in the case where doctor instructs.
3. driver, work high above the ground person use with caution.
4. strictly being taken by usage and dosage, the medicine should not largely be taken for a long time.
5. pair medicine and alcohol intolerance person disabling, allergic constitution person use with caution.
6. the property of drug is prohibitted the use of when changing.
7. the medicine is please placed on the place that children can not contact.
8. as use other medicines, using before the medicine ask Ref Dr or pharmacist.
Diagnostic criteria
The relevant treatment of the present invention is as follows：
1. general information
Now by taking clinical 100 hemorrhoid patients as an example, wherein man 45, age 18-70 Sui, female 55, age 20-60 Sui.
2. diagnostic criteria
Mixed hemorrhoids：Have difficulty in passing one's motions, there is a falling inflation sense, having a rest property of defecation time band blood, bleed or spray blood, haemorrhoids is deviate from.
3. treatment method：
Application method：Clean, with 1 gram or so of emulsifiable paste of the present invention, be sent into anus, once a day after an action of the bowels daily；Navel takes few
Perhaps emulsifiable paste is massaged into absorption, and 2 times a day.
4. efficacy assessment standard
It is effective：
Stool is normal, no falling inflation sense, without blood during defecation；Medication works after 2 hours, and symptom disappears within 24 hours.
Take a turn for the better：
Stool is normal, no falling inflation sense, without blood during defecation；Symptom disappears within 24 hours；
It is invalid：
Have difficulty in passing one's motions, there is a falling inflation sense, having a rest property of defecation time band blood, bleed or spray blood, haemorrhoids is deviate from；
5. treatment results (are shown in Table 1)
The observation of curative effect after treatment of table 1
| Disease example | Case load | It is effective | Take a turn for the better | It is invalid | It is efficient |
| Mixed hemorrhoids | 100 | 98 | 2 | 0 | 100% |
As a result show there are 98 recoveries from illness in 100 patients, cure rate is 98%, recurrence rate reduces by 80% compared with other medicines,
Treated fast 3-5 days compared with other medicines.
The beneficial effects of the invention are as follows：The present invention meets Chinese medical discrimination theory in Chinese medicine selection and compatibility, and prepares
Method is simple, with rapid-action, cure rate height, the advantages of uneasy to recur.
Embodiment
In order that the technical means, the inventive features, the objects and the advantages of the present invention are easy to understand, tie below
Specific embodiment is closed, the present invention is expanded on further.
Embodiment 1
A kind of emulsifiable paste for being used to treat hemorrhoid, the medicament being formulated by following bulk drug：Triamcinolone acetonide 1g, sulfuric acid are new
Mycin 7g, miconazole nitrate 10g, stearic acid 130g, tristerin 70g, atoleine 50ml, propane diols 80ml, azone
0.5ml, ethylparaben 1g, distilled water 650ml；
Preparation method is as follows：
1) to weigh each bulk drug by above-mentioned prescription stand-by；
2) by Triamcinolone acetonide, neomycinsulphate, miconazole nitrate grinds to form powdery, obtains granular material stand-by；
3) stearic acid is taken, tristerin, atoleine is put into container, heating water bath, and temperature control is in 70-80
DEG C, stirring is molten into oily mater, stand-by；
4) another taking ethylparaben stirs with propane diols, is added in the lump in 70-80 DEG C of distilled water in azone, stirs
Uniformly, aqueous mixture is obtained, it is stand-by；
5) by step 3) in oily mater be slowly added into step 4) in aqueous mixture in, do not stop stirring, treat temperature
Step 2 is added when degree is down to 60 DEG C) in granular material, stir.
Clean, with 1 gram or so of emulsifiable paste of the present invention, be sent into anus, once a day after an action of the bowels daily；Navel takes a little emulsifiable paste to massage
To absorbing, 2 times a day.Mixed hemorrhoids medication works after 2 hours, and symptom disappears within 24 hours, consolidates one week cure rate up to 100%；Anus
Fistula patient continuously uses 20 days, and silt block reduces and disappeared, and cure rate is up to 98%.
Embodiment 2
A kind of emulsifiable paste for being used to treat hemorrhoid, the medicament being formulated by following bulk drug：Triamcinolone acetonide 0.8g, sulfuric acid
Neomycin 8g, miconazole nitrate 9g, stearic acid 120g, tristerin 80g, atoleine 60ml, propane diols 70ml, azone
0.6ml, ethylparaben 0.9g, distilled water 600ml；
Preparation method is as follows：
1) to weigh each bulk drug by above-mentioned prescription stand-by；
2) by Triamcinolone acetonide, neomycinsulphate, miconazole nitrate grinds to form powdery, obtains granular material stand-by；
3) stearic acid is taken, tristerin, atoleine is put into container, heating water bath, and temperature control is in 70-80
DEG C, stirring is molten into oily mater, stand-by；
4) another taking ethylparaben stirs with propane diols, is added in the lump in 70-80 DEG C of distilled water in azone, stirs
Uniformly, aqueous mixture is obtained, it is stand-by；
5) by step 3) in oily mater be slowly added into step 4) in aqueous mixture in, do not stop stirring, treat temperature
Step 2 is added when degree is down to 60 DEG C) in granular material, stir.
Clean, with 1 gram or so of emulsifiable paste of the present invention, be sent into anus, once a day after an action of the bowels daily；Navel takes a little emulsifiable paste to massage
To absorbing, 2 times a day.Mixed hemorrhoids medication works after 2 hours, and symptom disappears within 24 hours, consolidates one week cure rate up to 100%；Anus
Fistula patient continuously uses 20 days, and silt block reduces and disappeared, and cure rate is up to 98%.
Embodiment 3
A kind of emulsifiable paste for being used to treat hemorrhoid, the medicament being formulated by following bulk drug：Triamcinolone acetonide 1.2g, sulfuric acid
Neomycin 8g, miconazole nitrate 12g, stearic acid 110g, tristerin 75g, atoleine 55ml, propane diols 85ml, nitrogen
Ketone 1ml, ethylparaben 1.2g, pure water 700ml；
Preparation method is as follows：
1) to weigh each bulk drug by above-mentioned prescription stand-by；
2) by Triamcinolone acetonide, neomycinsulphate, miconazole nitrate grinds to form powdery, obtains granular material stand-by；
3) stearic acid is taken, tristerin, atoleine is put into container, heating water bath, and temperature control is in 70-80
DEG C, stirring is molten into oily mater, stand-by；
4) another taking ethylparaben stirs with propane diols, is added in the lump in 70-80 DEG C of pure water in azone, stirs
Uniformly, aqueous mixture is obtained, it is stand-by；
5) by step 3) in oily mater be slowly added into step 4) in aqueous mixture in, do not stop stirring, treat temperature
Step 2 is added when degree is down to 60 DEG C) in granular material, stir.
Clean, with 1 gram or so of emulsifiable paste of the present invention, be sent into anus, once a day after an action of the bowels daily；Navel takes a little emulsifiable paste to massage
To absorbing, 2 times a day.Mixed hemorrhoids medication works after 2 hours, and symptom disappears within 24 hours, consolidates one week cure rate up to 100%；Anus
Fistula patient continuously uses 20 days, and silt block reduces and disappeared, and cure rate is up to 98%.
Easily it is lost in it was verified that lotion is made in the medicine；Suppository, patch, which is made, limitation, and emulsifiable paste is made the most
Ideal, it is easy to use, not easily run off, long action time.Other emulsifiable paste processed will select the materials such as lubrication, anti-corrosion, infiltration, can
As matrix, leading medicine is born, moreover it is possible to play auxiliary therapeutic action.The present invention is added and subtracted in proportion with reference to human-body safety dosage
Emulsifiable paste is made, result of the test display effect is particularly evident, symptom mitigation after 2 hours, symptom disappears within 24 hours.
Model case：
Korea Spro so-and-so, man, 52 years old, staff at Fuyang City environmental sanitation.Suffer from hemorrhoid more than 10 years, belong to heavier inside and outside hemorrhoid, just
Blood, can not sit, hurt like hell when serious, the excessively various patch of use, lotion, endo-medicine etc., fail recovery from illness.Use breast of the invention
Cream 3 days, stopping of suppurating of bleeding, continuous using after 20 days, haemorrhoids diminishes, and is not recurred always after healing.
Mr. Li, male, 45 years old, Fuyang City civil servant.Internal piles was suffered from 2008, is hard and dry, has blood in stool sometimes always, is ached
Bitterly, Repeated Operation was done, a variety of medicine Ji still multiple relapse has been eaten：Using emulsifiable paste of the present invention, symptom is whole after continuously treating 20 days
Disappear, do not recur so far.
Sun, man, 21 years old, Anhui people from Jieshou City, student.External piles was suffered from 2010, is hard and dry, pain due to hemorrhoid,
It can not attend class.Using emulsifiable paste of the present invention, same day symptom disappears, and consolidates and was cured using 2 weeks, pays a return visit, do not recur so far several times.
The general principle and principal character and advantages of the present invention of the present invention has been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the simply explanation described in above-described embodiment and specification is originally
The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (3)
1. a kind of emulsifiable paste for being used to treat hemorrhoid, it is characterised in that it is the medicament being formulated by following components：Triamcinolone acetonide
0.5-1.5g, neomycinsulphate 4-10g, miconazole nitrate 8-12g, stearic acid 100-200g, tristerin 50-100g,
Atoleine 40-70ml, propane diols 50-100ml, azone 0.1-1ml, ethylparaben 0.5-1.5g, distilled water 500-
800ml。
2. a kind of emulsifiable paste for being used to treat hemorrhoid according to claim 1, it is characterised in that it is to be prepared by following components
Medicament：Triamcinolone acetonide 1g, neomycinsulphate 7g, miconazole nitrate 10g, stearic acid 130g, tristerin 70g,
Atoleine 50ml, propane diols 80ml, azone 0.5ml, ethylparaben 1g, distilled water 650ml.
3. a kind of method for preparing emulsifiable paste described in claim 1 or 2, it is characterised in that comprise the following steps,
1) each component is weighed stand-by；
2) by Triamcinolone acetonide, neomycinsulphate, miconazole nitrate grinds to form powdery, obtains granular material stand-by；
3) stearic acid is taken, tristerin, atoleine is put into container, heating water bath, temperature control is stirred at 70-80 DEG C
Mix and be molten into oily mater, it is stand-by；
4) another taking ethylparaben stirs with propane diols, in the distilled water for adding 70-80 DEG C in the lump with azone, and stirring is equal
It is even, aqueous mixture is obtained, it is stand-by；
5) by step 3) in oily mater be slowly added into step 4) in aqueous mixture in, do not stop stirring, treat temperature drop
To at 60 DEG C add step 2) in granular material, stir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410691311.7A CN104490905B (en) | 2014-11-26 | 2014-11-26 | A kind of emulsifiable paste and preparation method for being used to treat hemorrhoid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410691311.7A CN104490905B (en) | 2014-11-26 | 2014-11-26 | A kind of emulsifiable paste and preparation method for being used to treat hemorrhoid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104490905A CN104490905A (en) | 2015-04-08 |
| CN104490905B true CN104490905B (en) | 2017-08-29 |
Family
ID=52932419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410691311.7A Active CN104490905B (en) | 2014-11-26 | 2014-11-26 | A kind of emulsifiable paste and preparation method for being used to treat hemorrhoid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104490905B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101385724A (en) * | 2007-09-14 | 2009-03-18 | 天津医科大学 | Arginine Ibuprofen cream and preparation method thereof |
| CN103933051B (en) * | 2014-05-12 | 2014-12-24 | 广东台城制药股份有限公司 | Triamcinolone acetonide acetat and preparation method thereof |
-
2014
- 2014-11-26 CN CN201410691311.7A patent/CN104490905B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104490905A (en) | 2015-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bartram | Bartram's encyclopedia of herbal medicine | |
| US20030185915A1 (en) | Synergetic composition for the treatment of psoriasis and other skin disorders and method therefor | |
| CN109288889A (en) | A kind of antibacterial gynecological composition, gel and preparation method thereof | |
| CN104173871B (en) | A kind of Chinese medicine composition for treating vulvitis and its application | |
| Zakeri et al. | The effect of Achillea millefolium L. on vulvovaginal candidiasis compared with clotrimazole: A randomized controlled trial | |
| CN103784878B (en) | Traditional Chinese medicine convulsion-relieving and nerve-calming pills/soup for treating mental disease and preparation method thereof | |
| CN104490905B (en) | A kind of emulsifiable paste and preparation method for being used to treat hemorrhoid | |
| CN101152546B (en) | Externally used preparations with functions of anti-inflammation, relieving itching and sterilization disinfection, and method for preparing the same | |
| CN106237029B (en) | A kind of aloe antibiotic gel and preparation method thereof | |
| CN105853463B (en) | A kind of preparation method and application for the Chinese medicine preparation treated ulcerative carbuncle ulcer, promote muscle growth | |
| CN107737216A (en) | A kind of Chinese medicine composition for preventing and treating the proliferation of mammary gland and preparation method thereof | |
| CN107617018B (en) | Pharmaceutical composition for treating livestock dermatitis herpetiformis and application method thereof | |
| CN102008586A (en) | Effective drug for treating skin disease | |
| CN103599228B (en) | Traditional Chinese medicine for preventing and treating hemorrhoids formation | |
| CN109908304A (en) | Chinese medicine composition and application thereof, traditional Chinese medicine for outer use and preparation method thereof | |
| CN104873866B (en) | A kind of Pu Ling basins inflammation health pharmaceutical preparation and its detection method for pelvic infecton | |
| CN104888002B (en) | A kind of local skin microecologic regulator | |
| CN104189657B (en) | External contraceptive for preventing and treating lower genital tract infection | |
| CN1088811A (en) | Medicinal liquid for treating tinea | |
| CN102366567B (en) | Pharmaceutical composition for treating condyloma acuminatum, and preparation and application method | |
| Redfern | Improving Acne, Eczema and Psoriasis in 30 Days: Clear Acne, Eczema and Psoriasis in 30 Days: Healthy Skin Rehabilitation For The Long Term | |
| CN107233446A (en) | A kind of medical chitosan oligosaccharide complexing agent dressing and preparation method thereof | |
| CN106039315A (en) | Pregnant vulva eczema nursing drug and preparation method thereof | |
| Eefan et al. | DETERMINATION OF A NUMBER OF PHYSIOLOGICAL AND IMMUNOLOGICAL ASPECTS OF THE EFFECT OF CANDIDA ALBICANS ON FEMALE RATS AND THEIR TREATMENT WITH AQUEOUS EXTRACT OF DANDELION ROOT AND FLUCONAZOLE | |
| CN106039239B (en) | A kind of Chinese materia medica preparation that treating female infertility, preparation method and its usage |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |