CN104490882A - Traditional Chinese veterinary medicine for treating duck infectious serositis diseases and preparation method thereof - Google Patents
Traditional Chinese veterinary medicine for treating duck infectious serositis diseases and preparation method thereof Download PDFInfo
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- CN104490882A CN104490882A CN201410702800.8A CN201410702800A CN104490882A CN 104490882 A CN104490882 A CN 104490882A CN 201410702800 A CN201410702800 A CN 201410702800A CN 104490882 A CN104490882 A CN 104490882A
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- florfenicol
- rifampicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
The invention relates to a traditional Chinese veterinary medicine for treating duck infectious serositis diseases. The traditional Chinese veterinary medicine is prepared from the following raw materials in parts by weight: 5-10 parts of florfenicol, 1-5 parts of rifampicin, 8-15 parts of PEG 6000, 5-10 parts of PVP-K30, 5-10 parts of beta-cyclodextrin, 7-12 parts of tween-80, 15-25 parts of glycerol and 25-40 parts of purified water. The traditional Chinese veterinary medicine provided by the invention is easily available in raw material and low in price, is safe and does not have toxic or side effects on livestock and poultry bodies; and a preparation method of the traditional Chinese veterinary medicine, provided by the invention, is simple, easy to operate and suitable for large-scale production and popularization.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind ofly treat herbal medicine of infectious serositis in duck disease and preparation method thereof.
Background technology
Infectious serositis in duck, also known as Riemerella anatipestifer infection, new duck disease, pest of duck syndrome or duck septicemia, is a kind of contagious infection disease caused by riemerella anatipestifer (RA).Be more common in duck in 2 one 7 week age clinically, in acute and chronic process, main manifestations is eye, nasal secretions, breathe, cough, dysentery, ataxia and head and neck tremble.The feature of pathological change is fibrinous pericarditis, cellulosic perihepatitis, cellulosic airsacculitis, cheesy salpingitis and arthritis.If not in time control or prevention and controls improper, duck group large quantities of morbidity death can be caused.For the control of this disease, the medicine that data is introduced is a lot of, but some medicines are due to life-time service, and make the pathogenic bacteria in duck body create Drug resistance, prevention effect is not ideal enough.Infectious serositis in duck, also known as Riemerella anatipestifer infection, new duck disease, pest of duck syndrome or duck septicemia, is a kind of contagious infection disease caused by riemerella anatipestifer (RA).Be more common in 2-7 duck in age in week clinically, in acute and chronic process, main manifestations is eye, nasal secretions, breathe, cough, dysentery, ataxia and head and neck tremble.The feature of pathological change is fibrinous pericarditis, cellulosic perihepatitis, cellulosic airsacculitis, cheesy salpingitis and arthritis.If not in time control or prevention and controls improper, duck group large quantities of morbidity death can be caused.For the control of this disease, the medicine that data is introduced is a lot of, but some medicines are due to life-time service, and make the pathogenic bacteria in duck body create Drug resistance, prevention effect is not ideal enough.
According to market feedback, duck oromeningitis is the contagious disease of a kind of main harm duckling caused by riemerella anatipestifer.Along with intensive, the scale of aquaculture and the fast development of industrialization level are throughout all parts of the country; the economic loss caused every year reaches several hundred million unit; there is effect worse and worse in anti-the curing the disease of current drug application; product of the present invention substantially increases the therapeutic effect of duck oromeningitis, thus decreases very large economic loss to aquaculture.
Summary of the invention
The object of the present invention is to provide a kind of herbal medicine for the treatment of infectious serositis in duck disease, this medicine can treat infectious serositis in duck disease, reduces duck to the drug resistance of medicine.
In order to achieve the above object, the present invention is by the following technical solutions:
The invention provides a kind of herbal medicine for the treatment of infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 5 ~ 10, rifampicin 1 ~ 5, PEG 6,000 8 ~ 15, PVP-K30 5 ~ 10, beta-schardinger dextrin-5 ~ 10, tween 80 7 ~ 12, glycerol 15 ~ 25 and purified water 25 ~ 40.
The herbal medicine of described treatment infectious serositis in duck disease is made up of the crude drug of following weight portion: florfenicol 6 ~ 10, rifampicin 3 ~ 5, PEG 6,000 10 ~ 13, PVP-K30 8 ~ 10, beta-schardinger dextrin-5 ~ 7, tween 80 9 ~ 12, glycerol 18 ~ 22 and purified water 25 ~ 30.
The herbal medicine of described treatment infectious serositis in duck disease is made up of the crude drug of following weight portion: florfenicol 10, rifampicin 5, PEG 6,000 12, PVP-K30 10, beta-schardinger dextrin-5, tween 80 12, glycerol 20 and purified water 26.
Described herbal medicine dosage form is granule.
The preparation method concrete steps of the herbal medicine of described treatment infectious serositis in duck disease are as follows:
(1), under stirring, under 45 ~ 65 DEG C of water-baths, add formula ratio purified water, PEG 6000, PVP-K30 and beta-schardinger dextrin-in container, stirring and dissolving obtains mixture a;
(2), under stirring, in mixture a, add formula ratio florfenicol and tween 80, be stirred to transparent, then add till formula ratio glycerol stirs and obtain mixture b;
(3) obtain dry powder by spray-dried for mixture b, add the obtained soft material of formula ratio rifampicin mixing in the most backward dry powder, pelletize, dries and get final product.
Herbal medicine dosage form of the present invention is granule, according to the needs of special circumstances, also can make the dosage form of the States Pharmacopoeia specifications such as powder, powder.
compared with prior art, the beneficial effect that obtains of the present invention:
The herbal medicine of florfenicol of the present invention and the composite system of rifampicin, crude drug is easy to get, cheap and safety, without any side effects to poultry body.Preparation method of the present invention is simple, easy to operate, is suitable for large-scale production and applies.
the present invention selects effect of raw material as follows:
Florfenicol: chemical name is that D (+)-Su-1-is to first vitriol base phenyl-2-two chloroethene phthalein amino-3-fluorine propanol, be the third generation chloromycetin extensive pedigree antibiotic of chemosynthesis, all have inhibitory action to multiple gram positive bacteria and gram negative bacteria.Antibacterial activity and the chloromycetin of florfenicol are closely similar, but because of in structure without para-position nitro without potential induced aplastic anemia effect.Therefore, the eighties in last century is by after Schering-Plough Developed, nineteen ninety in Japan's listing, then goes on the market, for cattle respiratory system disease, fish pasteurellosis bacillus, fish streptococcicosis etc. in states such as Norway, France, Britain, Austria, Mexico and Spain first.1999, florfenicol and the preparation thereof of the manufacturer production such as Zhong Mu Anda, Hubei pharmaceutcal corporation, Ltd were also approved for national two class novel chiral synthon, for the bacterial disease of the pig caused by sensitive organism, fowl and fish.Also go through as the feed additive of pig in Japan and Mexico, trade name is respectively Florocol and Nunor.In recent years, along with deepening continuously of research, the experimental study in pharmacokinetics, pharmacodynamics, toxicology etc. makes people have comprehensive understanding to this medicine.The Antibacterial Mechanism of florfenicol is identical with chloromycetin and thiamphenicol, mainly through acting on bacterial ribosome 505 subunit, suppressing second phthalidyl transferring enzyme, thus suppressing the extension of chain, the synthesis of interference bacterioprotein.Thiamphenicol and chloramphenicol resistance bacteria strain can produce the second phthalidyl transferring enzyme (Acetyl-transferase) propagated with plasmid usually; this enzyme can make-the OH in first vitriol mycin and chloromycetin structure on C-3 methyl position that the reaction of second phthaleinization occurs, and therefore loses pharmacologically active.Florfenicol is then because the-OH of C-3 position is replaced by-F, can not by the destruction of second phthalidyl transferring enzyme, so still responsive to florfenicol to the bacterial strain of thiamphenicol and chloramphenicol resistance, its antibacterial activity, higher than chloromycetin and thiamphenicol, so far florfenicol veterinary clinic is widely used.
On October 8th, 2002, the 1500 plumage 30 age in days eggs of raising in the feed lot of lane town one, Fengcheng City, Jiangxi Province are ill with duckling, and part sick duck spirit is depressed, and necking down is drowsiness, and edge is dug earth with the snout, and bipod is weak, is reluctant to walk about, crowded or heap.The 2d symptom of morbidity is even more serious, and spirit is extremely depressed, and starts to occur death.The sick duck had shakes all over when can not stand or stand, and again and again nods or swings, and turns over or swing to side after some healths.Ceaselessly to flap during struggle dipteron, pedal after two lower limbs.The loss of appetite that symptom is slightly light or absolutely useless, eye nose has serosity or emulsion sexual secretion, and cough, sneeze, feces is yellow green, is infectious serositis in duck through clinical definite.To October 12, ill duck is dead 70 plumages altogether.October 10, to October 12, successively carried out clinical treatment with gentamycin and enrofloxacin, and effect is not very desirable, and clinical death rate is about 50%.Started October 13 to treat with florfenicol, after the treatment of florfenicol drinking-water, mortality rate drops to 10% immediately, and the state of an illness obtains effective control, carries out clinical treatment have received good effect with florfenicol.
Rifampicin is the semisynthetic antibiotics of rifomycins, its chemistry 3 one (4 monomethyl 1 croak a crash formimino group) rifamycin by name.Usually this medicine is rufous crystalline powder, and slightly soluble in water, be easy to be dissolved in chloroform, be soluble in ethyl acetate and methanol, molecular weight is 822.95.Rifamycin produces primarily of gram positive bacteria alnycolatopsis.These antibiotic, except pathogen such as energy tuberculosis, leprosy etc., also find that they are effective to multiple pathogens.Rifampicin is semi-synthetic wide-spectrum bactericide, and with the beta subunit strong bonded of RNA polymerase depending on DNA, the synthesis of anti-bacteria RNA, prevents this enzyme to be connected with DNA, thus blocks rna transcription process.Because rifampicin easily produces drug resistance, present stage is except treatment tuberculosis and be used as except external eye drop, and rifampicin is cured a line medication from people and withdrawn to, and due to the characteristic of rifampicin, veterinary one line is just at the clinical efficacy of Devoting Major Efforts To Developing rifampicin.The has a broad antifungal spectrum of rifampicin, effective to multiple pathogens, but the application on present stage veterinary clinic need Devoting Major Efforts To Developing, and the novel formulation Development Level for rifampicin also has much room for improvement.In the research carrying out infectious serositis in duck, find that rifampicin has potent inhibitory action to inner Mo Shi bacillus clinically, for the feature of rifampicin poorly water-soluble, the granule that we adopt water solublity rifampicin that market is sold and florfenicol to make, has had good curative effect to duck oromeningitis.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described, but do not limit content of the present invention.
embodiment 1
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 5 ~ 10, rifampicin 1 ~ 5, PEG 6,000 8 ~ 15, PVP-K30 5 ~ 10, beta-schardinger dextrin-5 ~ 10, tween 80 7 ~ 12, glycerol 15 ~ 25 and purified water 25 ~ 40.
The herbal medicine of described treatment infectious serositis in duck disease is made up of the crude drug of following weight portion: florfenicol 6 ~ 10, rifampicin 3 ~ 5, PEG 6,000 10 ~ 13, PVP-K30 8 ~ 10, beta-schardinger dextrin-5 ~ 7, tween 80 9 ~ 12, glycerol 18 ~ 22 and purified water 25 ~ 30.
The preparation method concrete steps of the herbal medicine of described treatment infectious serositis in duck disease are as follows:
(1), under stirring, under 45 ~ 65 DEG C of water-baths, add formula ratio purified water, PEG 6000, PVP-K30 and beta-schardinger dextrin-in container, stirring and dissolving obtains mixture a;
(2), under stirring, in mixture a, add formula ratio florfenicol and tween 80, be stirred to transparent, then add till formula ratio glycerol stirs and obtain mixture b;
(3) by spray-dried for mixture b, spray drying device arranges inlet temperature 180 DEG C of outlet temperatures 200 DEG C of spraying dry and obtains dry powder, and add the obtained soft material of formula ratio rifampicin mixing in the most backward dry powder, pelletize, dries and get final product.
embodiment 2
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 10, rifampicin 5, PEG 6,000 12, PVP-K30 10, beta-schardinger dextrin-5, tween 80 12, glycerol 20 and purified water 26.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 3
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 5, rifampicin 2, PEG 6,000 10, PVP-K30 7, beta-schardinger dextrin-6, tween 80 10, glycerol 25 and purified water 37.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 4
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 8, rifampicin 5, PEG 6,000 12, PVP-K30 10, beta-schardinger dextrin-7, tween 80 8, glycerol 22 and purified water 27.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 5
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 6, rifampicin 4, PEG 6,000 8, PVP-K30 5, beta-schardinger dextrin-10, tween 80 7, glycerol 15 and purified water 30.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 6
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 7, rifampicin 1, PEG 6,000 15, PVP-K30 9, beta-schardinger dextrin-5, tween 80 8, glycerol 25 and purified water 40.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 7
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 8, rifampicin 2, PEG 6,000 13, PVP-K30 7, beta-schardinger dextrin-6, tween 80 9, glycerol 18 and purified water 32.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 8
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 7.5, rifampicin 3.2, PEG 6,000 12.5, PVP-K30 6.8, beta-schardinger dextrin-9.5, tween 80 11, glycerol 19 and purified water 38.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 9
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 9.5, rifampicin 2.5, PEG 6,000 13.5, PVP-K30 5, beta-schardinger dextrin-8.2, tween 80 7.6, glycerol 21.5 and purified water 28.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
embodiment 10
Treat a herbal medicine for infectious serositis in duck disease, be made up of the raw material of following weight portion: florfenicol 8.5, rifampicin 1.5, PEG 6,000 11.5, PVP-K30 7.8, beta-schardinger dextrin-8, tween 80 8.7, glycerol 19 and purified water 33.
The present embodiment preparation method is identical with the preparation method of embodiment 1.
test example
Experimental animal: according to epidemiology, clinical symptoms, pathology cuts open inspection, identification and isolation of pathogen comprehensive diagnos is duck oromeningitis, random selecting 880, be divided into 11 groups, often organize 80, the granule drinking-water that test group 1 ~ 9 adopts embodiment 2 ~ 10 to prepare successively is treated, matched group adopts commercially available pest of duck speed to go out, and blank group does not use any medicine, be used in conjunction 3 days, observe the curative effect also adds up healing, effective and invalid number, calculate cure rate, result of the test refers to following table 1.
Curative effect judging standard:
Cure: mental status is good, feed intake is normal, and feces detects without exception;
Effective: disease is clearly better;
Invalid: mental status is poor, draw white or faint yellow water sample to wash just, astasia, rocks on foot, and shed feathers phenomenon.
Conclusion: as can be seen from Table 1, the cure rate of test group 1 ~ 9 when treating chicken respiratory and infecting reaches more than 93%, and matched group is 64%.Statistical analysis shows, the cure rate of test group is significantly higher than matched group.Result of the test shows, granule prepared by the embodiment of the present invention 2 ~ 10 infects chicken respiratory and has good therapeutic efficiency.
Claims (5)
1. treat the herbal medicine of infectious serositis in duck disease for one kind, it is characterized in that, be made up of the raw material of following weight portion: florfenicol 5 ~ 10, rifampicin 1 ~ 5, PEG 6,000 8 ~ 15, PVP-K30 5 ~ 10, beta-schardinger dextrin-5 ~ 10, tween 80 7 ~ 12, glycerol 15 ~ 25 and purified water 25 ~ 40.
2. treat the herbal medicine of infectious serositis in duck disease according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: florfenicol 6 ~ 10, rifampicin 3 ~ 5, PEG 6,000 10 ~ 13, PVP-K30 8 ~ 10, beta-schardinger dextrin-5 ~ 7, tween 80 9 ~ 12, glycerol 18 ~ 22 and purified water 25 ~ 30.
3. treat the herbal medicine of infectious serositis in duck disease according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: florfenicol 10, rifampicin 5, PEG 6,000 12, PVP-K30 10, beta-schardinger dextrin-5, tween 80 12, glycerol 20 and purified water 26.
4. treat the herbal medicine of infectious serositis in duck disease according to claim 1, it is characterized in that described herbal medicine dosage form is granule.
5. according to any one of claims 1 to 3, treat the preparation method of the herbal medicine of infectious serositis in duck disease, it is characterized in that, concrete steps are as follows:
Under stirring, under 45 ~ 65 DEG C of water-baths, add formula ratio purified water, PEG 6000, PVP-K30 and beta-schardinger dextrin-in container, stirring and dissolving obtains mixture a;
Under stirring, in mixture a, add formula ratio florfenicol and tween 80, be stirred to transparent, then add till formula ratio glycerol stirs and obtain mixture b;
Obtain dry powder by spray-dried for mixture b, add the obtained soft material of formula ratio rifampicin mixing in the most backward dry powder, pelletize, dries and get final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105560189A (en) * | 2016-01-22 | 2016-05-11 | 山东畜牧兽医职业学院 | Florfenicol slow-release dispersoid and preparation method thereof |
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2014
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| WO1993000072A1 (en) * | 1991-06-27 | 1993-01-07 | Richardson Vicks, Inc. | Process for solubilizing difficultly soluble pharmaceutical actives |
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| CN105560189A (en) * | 2016-01-22 | 2016-05-11 | 山东畜牧兽医职业学院 | Florfenicol slow-release dispersoid and preparation method thereof |
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