CN104474595B - Production method of dilayer compounding coated esophageal stent with esophageal cancer treatment assisting function - Google Patents
Production method of dilayer compounding coated esophageal stent with esophageal cancer treatment assisting function Download PDFInfo
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- CN104474595B CN104474595B CN201410640182.9A CN201410640182A CN104474595B CN 104474595 B CN104474595 B CN 104474595B CN 201410640182 A CN201410640182 A CN 201410640182A CN 104474595 B CN104474595 B CN 104474595B
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Abstract
The invention relates to a production method of a dilayer compounding coated esophageal stent with an esophageal cancer treatment assisting function. The method comprises the following steps: making an inner layer polycaprolactone compact surface on the surface of a Ni-Ti memory esophageal stent through a solution film paving technology; spinning a fiber film obtained by using a solution of an outer fiber film to the inner layer polycaprolactone compact film through an electrostatic spinning technology by using a rotary receiver with the Ni-Ti memory esophageal stent with the surface provided with the inner layer polycaprolactone compact film as an electrostatic spinning device with a mixed liquid obtained through blending and dissolving an organic polymer material and an anticancer drug in an organic solvent as the solution for making the outer layer fiber film to obtain a dilayer compounding coating with an esophageal cancer treatment function. The dilayer compounding coating is obtained through compounding the outer layer fiber film with the inner layer polycaprolactone compact film when the organic solvent does not volatilize completely, and two layers are tightly adhered to each other. The dilayer compounding coated esophageal stent improves the cell compatibility of film materials, and also realizes the controlled release of drugs; and the method has the advantages of simplicity, easy operation and low cost.
Description
Technical field
The present invention relates to the preparation of Multi-functional food pipe holder overlay film is and in particular to have the double of auxiliary treatment cancer of the esophagus function
The preparation method of the Esophageal Stent of layer compound film laminating.
Background technology
The cancer of the esophagus is a kind of common tumor in digestive tract, and the whole world there are about 310,000 people every year and dies from the cancer of the esophagus, wherein 160,000
Betide China.Classical symptom the being by property dysphagia of the cancer of the esophagus, this can lead to patient gradually to become thin, and directly reduces patient
Quality of life, or even dead.Because the early symptom of the cancer of the esophagus is inconspicuous, when making a definite diagnosis, cancer cell is likely to be at the middle and later periods
Or spread, in addition, the lesion volume scope of some patient is larger, so, only about 50% patient is suitable for hand
Art is excised.So, for feed, the dysdipsia of reduction of patient, implanting Esophageal Stent is a kind of critically important palliative treatment.
The overlay film frame that Esophageal Stent is divided into bare bracket and coats the membrane material that has specific characteristics.Compared to bare bracket, overlay film props up
Frame can effectively stop hyperplastic tissue from growing to internal stent, and after lemostenosis is alleviated, is easy to take out, so, cover
Covering material on membrane support needs there is good mechanical property and biocompatibility.On this basis, anticarcinogen plus
Enter in the overlay film of overlay film frame, both can play the effect of general overlay film frame it is also possible to local fixed point slow releasing pharmaceutical, reach
More rapidly and effectively auxiliary kills the effect of cancer cell, utilization rate more targeted more than general intravenous injection anticarcinogen
Higher.
In conjunction with the medical present situation of China, it is badly in need of a kind of overlay film with the auxiliary treatment cancer of the esophagus of implantable focal zone at present
Support, and require this overlay film can either adhere to well on metallic support it is also possible to avoid pullling during support takes out
Wound causes secondary injury, reaches the adjuvant treatment effect to the cancer of the esophagus simultaneously.
Content of the invention
The purpose of the present invention is for the deficiencies in the prior art, provides a kind of bilayer with auxiliary treatment cancer of the esophagus function
The preparation method of the Esophageal Stent of compound film laminating.
The present invention prepares the solution of preparation inner compact layer film first, and remembers food by the method for solution plastic film mulch in ni-ti
The surface of pipe holder is obtained inner compact layer film；Then it is dissolved in organic solvent with the blending of high-molecular organic material and cancer therapy drug
The mixed solution obtaining is the solution preparing outer layer fiber film, and the ni-ti having inner compact layer film with surface remembers Esophageal Stent and is
The rotating receiver of electrospinning device, using electrostatic spinning technique by by the tunica fibrosa that the solution of outer layer fiber film obtains spin in
On inner compact layer film, thus obtain the two-layer compound overlay film with treatment cancer of the esophagus function；This two-layer compound overlay film is by outer layer
Tunica fibrosa and inner compact layer film organic solvent be not yet evaporated completely full-time be composited, laminating is closely.Obtained by this preparation method
The two-layer compound overlay film of the Esophageal Stent of two-layer compound overlay film with auxiliary treatment cancer of the esophagus function be by inner compact layer film
Constitute with outer layer fiber film, its inner compact layer film can be good at adhering on metallic support, and outer layer fiber film is by containing
Organic polymer and the mixed solution of cancer therapy drug, are made using electrostatic spinning technique, the fiber of the softness of this outer layer fiber film
The mechanical property of material is weaker, can avoid causing secondary injury to wound during the taking-up of support；It can in addition contain control
The release of cancer therapy drug processed.
The preparation method of the Esophageal Stent of two-layer compound overlay film with auxiliary treatment cancer of the esophagus function of the present invention includes
Following steps:
(1) polycaprolactone (pcl) internal layer coating solution is prepared in preparation: polycaprolactone is dissolved in organic solvent, is configured to dense
Spend the solution for 10～20%w/v, (general stirring 3 hour about) is stirred at room temperature uniformly；
(2) prepare internal layer polycaprolactone (pcl) dense film: the solution that step (1) is obtained falls in culture dish, will compress
Ni-ti memory Esophageal Stent be placed in this culture dish roll, until polycaprolactone solution this compression ni-ti remember oesophagus
The surface uniform fold of support；Discharge the ni-ti memory Esophageal Stent of this compression, make the ni-ti of compression remember Esophageal Stent extensive
Arrive original length again, the surface remembering Esophageal Stent in ni-ti obtains internal layer polycaprolactone dense film；
(3) mixed liquor of outer layer fiber film is prepared in preparation: high-molecular organic material is dissolved in organic solvent, is configured to
Concentration is the solution of 9～15%w/v, adds cancer therapy drug, (general stirring 12 hour about) is stirred at room temperature and uniformly, is mixed
Liquid；
(4) prepare two-layer compound overlay film: the mixed liquor that step (3) is obtained injects in the syringe of electrospinning device,
Add the stainless steel syringe needle of a diameter of 0.3～0.7mm in the front end of syringe, return to original length with what step (2) obtained
Ni-ti memory Esophageal Stent be rotating receiver；It is 12～25kv in voltage, solution flow rate is 3～8ml/h, Rotation of receiver
Device apart from stainless steel syringe needle be 10～25cm under conditions of carry out electrostatic spinning, thus ni-ti remember Esophageal Stent surface
Obtain being contained the bilayer that the tunica fibrosa of high-molecular organic material and cancer therapy drug is constituted by internal layer polycaprolactone dense film and outer layer
Compound film laminating；(time that general room temperature in vacuo be dried be 24～48 hour) is dried in room temperature in vacuo, removes the organic molten of residual
Agent, obtains the Esophageal Stent with the two-layer compound overlay film of auxiliary treatment cancer of the esophagus function.This has auxiliary treatment cancer of the esophagus work(
The Esophageal Stent of the two-layer compound overlay film of energy preserves in 4 DEG C of drying boxes.
Addition cancer therapy drug described in step (3), the addition of its cancer therapy drug be according to cancer therapy drug quality with dense
Spend the mass values for the high-molecular organic material in the solution of 9～15%w/v to add cancer therapy drug for 3～15%.
The thickness of the outer layer fiber film of described two-layer compound overlay film is 30～150 μm.
The thickness of the inner compact layer film of described two-layer compound overlay film is 10～80 μm.
Described high-molecular organic material is selected from poly lactic coglycolic acid (plga), polycaprolactone (pcl), gelatin
One or more of (gt).The weight average molecular weight of described pcl is 50,000～200,000.
The weight average molecular weight of described plga is 50,000～200,000.
Described cancer therapy drug is selected from one of taxol, adriamycin, 5 FU 5 fluorouracil etc..
Described organic solvent is selected from dmf, acetone, trifluoroethanol, hexafluoroisopropanol, oxolane, chloroform, dichloromethane
One of alkane, dimethyl sulfoxide (DMSO) or two kinds.
Described electrospinning device is many spinning heads electrostatic spinning machine.
Beneficial effects of the present invention: the food of the two-layer compound overlay film with auxiliary treatment cancer of the esophagus function of present invention preparation
Pipe holder, inner compact layer film can be good at adhering on metallic support, and the power of the fibrous material of the softness of outer layer fiber film
Learn performance weaker, secondary injury will not be caused to wound during the taking-up of Esophageal Stent.It is loaded with two-layer compound overlay film
Cancer therapy drug, by regulating and controlling the ratio of high-molecular organic material, also achieves while improving the cell compatibility of membrane material
The control release of medicine；And make the cancer therapy drug in this two-layer compound covering material maintain the lasting killing to cancer cell to make
Used time, the injury to normal cell is less.This has the Esophageal Stent of two-layer compound overlay film of auxiliary treatment cancer of the esophagus function
The process is simple of preparation method, easily operated and low cost, have wide practical use.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail, but should not be understood as the present invention is protected
The restriction of scope, all based on above-mentioned technological thought, the modification made using ordinary skill knowledge and customary means, replace
Change, change and belong to the scope of the present invention.
Embodiment 1
(1) polycaprolactone (pcl, weight average molecular weight is 100,000) internal layer coating solution is prepared in preparation: pcl is dissolved in oxolane
In, it is configured to the solution that concentration is 10%w/v, be stirred at room temperature 3 hours about；
(2) prepare internal layer pcl dense film: the solution that step (1) is obtained falls in culture dish, by the ni-ti note of compression
Recall Esophageal Stent and be placed in rolling in this culture dish, until the surface that pcl solution remembers Esophageal Stent in the ni-ti of this compression is uniform
Cover；Take out and discharge the ni-ti memory Esophageal Stent of this compression, so that the ni-ti memory Esophageal Stent of compression is returned to original
Length, the surface remembering Esophageal Stent in ni-ti obtains the internal layer polycaprolactone dense film that thickness is about 10 μm；
(3) mixed liquor of outer layer fiber film is prepared in preparation: by plga (weight average molecular weight is 80,000), pcl (weight average molecular weight
For 200,000) and gt, the ratio co-dissolve with the mass ratio of plga:pcl:gt as 10:2.5:5, in hexafluoroisopropanol, prepares
Become the solution that concentration is 11%w/v, add taxol, be stirred at room temperature 12 hours about, the mixed liquor being uniformly mixed；It is purple
The addition of China fir alcohol is total matter that quality and concentration according to taxol is plga, the pcl and gt solute in the solution of 11%w/v
The ratio of amount to add taxol for 10%；
(4) prepare two-layer compound overlay film: the mixed liquor injection many spinning heads Static Spinning mixing that step (3) is obtained
In the syringe of silk machine, add the stainless steel syringe needle of a diameter of 0.5mm, the recovery obtaining with step (2) in the front end of syringe
Ni-ti memory Esophageal Stent to original length is rotating receiver；It is 20kv in voltage, solution flow rate is 5ml/h, rotation connects
Receive device apart from stainless steel syringe needle be 20cm under conditions of carry out electrostatic spinning, thus ni-ti remember Esophageal Stent surface obtain
The two-layer compound constituting to the tunica fibrosa being contained plga, pcl, gt and taxol by internal layer polycaprolactone dense film and outer layer is covered
Film, and the thickness of outer layer fiber film is about 150 μm；It is dried 48 hours in room temperature in vacuo, remove the organic solvent of residual, had
There is the Esophageal Stent of the two-layer compound overlay film of auxiliary treatment cancer of the esophagus function.The bilayer that this has auxiliary treatment cancer of the esophagus function is multiple
The Esophageal Stent closing overlay film preserves in 4 DEG C of drying boxes.
Embodiment 2
(1) polycaprolactone (pcl, weight average molecular weight is 100,000) internal layer coating solution is prepared in preparation: pcl is dissolved in oxolane
In, it is configured to the solution that concentration is 15%w/v, be stirred at room temperature 3 hours about；
(2) prepare internal layer pcl dense film: the solution that step (1) is obtained falls in culture dish, by the ni-ti note of compression
Recall Esophageal Stent and be placed in rolling in this culture dish, until the surface that pcl solution remembers Esophageal Stent in the ni-ti of this compression is uniform
Cover；Take out and discharge the ni-ti memory Esophageal Stent of this compression, so that the ni-ti memory Esophageal Stent of compression is returned to original
Length, the surface remembering Esophageal Stent in ni-ti obtains the internal layer polycaprolactone dense film that thickness is about 50 μm；
(3) mixed liquor of outer layer fiber film is prepared in preparation: by plga (weight average molecular weight is 200,000), pcl (weight average molecular weight
For 100,000) and gt, the ratio co-dissolve with the mass ratio of plga:pcl:gt as 10:2.5:1, in hexafluoroisopropanol, prepares
Become the solution that concentration is 9%w/v, add taxol, be stirred at room temperature 12 hours about, the mixed liquor being uniformly mixed；It is purple
The addition of China fir alcohol is the gross mass that quality and concentration according to taxol is plga, pcl and gt in the solution of 9%w/v
Ratio to add taxol for 3%；
(4) prepare two-layer compound overlay film: the mixed liquor injection many spinning heads Static Spinning mixing that step (3) is obtained
In the syringe of silk machine, add the stainless steel syringe needle of a diameter of 0.3mm, the recovery obtaining with step (2) in the front end of syringe
Ni-ti memory Esophageal Stent to original length is rotating receiver；It is 12kv in voltage, solution flow rate is 3ml/h, rotation connects
Receive device apart from stainless steel syringe needle be 10cm under conditions of carry out electrostatic spinning, thus ni-ti remember Esophageal Stent surface obtain
The two-layer compound constituting to the tunica fibrosa being contained plga, pcl, gt and taxol by internal layer polycaprolactone dense film and outer layer is covered
Film, and the thickness of outer layer fiber film is about 100 μm；It is dried 48 hours in room temperature in vacuo, remove the organic solvent of residual, had
There is the Esophageal Stent of the two-layer compound overlay film of auxiliary treatment cancer of the esophagus function.The bilayer that this has auxiliary treatment cancer of the esophagus function is multiple
The Esophageal Stent closing overlay film preserves in 4 DEG C of drying boxes.
Embodiment 3
(1) polycaprolactone (pcl, weight average molecular weight is 50,000) internal layer coating solution is prepared in preparation: pcl is dissolved in dichloromethane
In, it is configured to the solution that concentration is 20%w/v, be stirred at room temperature 3 hours about；
(2) prepare internal layer pcl dense film: the solution that step (1) is obtained falls in culture dish, by the ni-ti note of compression
Recall Esophageal Stent and be placed in rolling in this culture dish, until the surface that pcl solution remembers Esophageal Stent in the ni-ti of this compression is uniform
Cover, take out and discharge the ni-ti memory Esophageal Stent of this compression, so that the ni-ti memory Esophageal Stent of compression is returned to original
Length, the surface remembering Esophageal Stent in ni-ti obtains the internal layer polycaprolactone dense film that thickness is about 80 μm；
(3) mixed liquor of outer layer fiber film is prepared in preparation: by plga (weight average molecular weight is 50,000), pcl (weight average molecular weight
For 200,000) and gt, the ratio co-dissolve with the mass ratio of plga:pcl:gt as 10:2.5:1, in hexafluoroisopropanol, prepares
Become the solution that concentration is 15%w/v, add taxol, be stirred at room temperature 12 hours about, the mixed liquor being uniformly mixed；It is purple
The addition of China fir alcohol is total matter that quality and concentration according to taxol is plga, the pcl and gt solute in the solution of 15%w/v
The ratio of amount to add taxol for 3%；
(4) prepare two-layer compound overlay film: the mixed liquor injection many spinning heads Static Spinning mixing that step (3) is obtained
In the syringe (specification is 5ml) of silk machine, add the stainless steel syringe needle of a diameter of 0.7mm in the front end of syringe, with step (2)
The ni-ti memory Esophageal Stent returning to original length obtaining is rotating receiver；It is 25kv in voltage, solution flow rate is
8ml/h, rotating receiver apart from stainless steel syringe needle be 25cm under conditions of carry out electrostatic spinning, thus ni-ti remember oesophagus
The surface of support obtains being contained what the tunica fibrosa of plga, pcl, gt and taxol was constituted by internal layer polycaprolactone dense film and outer layer
Two-layer compound overlay film, and the thickness of outer layer fiber film is about 50 μm；It is dried 48 hours in room temperature in vacuo, remove the organic molten of residual
Agent, obtains the Esophageal Stent with the two-layer compound overlay film of auxiliary treatment cancer of the esophagus function.This has auxiliary treatment cancer of the esophagus work(
The Esophageal Stent of the two-layer compound overlay film of energy preserves in 4 DEG C of drying boxes.
Embodiment 4
(1) polycaprolactone (pcl, weight average molecular weight is 200,000) internal layer coating solution is prepared in preparation: pcl is dissolved in oxolane
In, it is configured to the solution that concentration is 10%w/v, be stirred at room temperature 3 hours about；
(2) prepare internal layer pcl dense film: the solution that step (1) is obtained falls in culture dish, by the ni-ti note of compression
Recall Esophageal Stent and be placed in rolling in this culture dish, until the surface that pcl solution remembers Esophageal Stent in the ni-ti of this compression is uniform
Cover, take out and discharge the ni-ti memory Esophageal Stent of this compression, so that the ni-ti memory Esophageal Stent of compression is returned to original
Length, the surface remembering Esophageal Stent in ni-ti obtains the internal layer polycaprolactone dense film that thickness is about 30 μm；
(3) mixed liquor of outer layer fiber film is prepared in preparation: by plga (weight average molecular weight is 100,000) and pcl (Weight-average molecular
Measure as 100,000), the mixing that the ratio co-dissolve with the mass ratio of plga:pcl as 4:1 forms in oxolane, chloroform and dmf
In (volume ratio is 2:1:2) in solvent, it is configured to the solution that concentration is 15%w/v, adds 5 FU 5 fluorouracil, be stirred at room temperature 12 little
When about, the mixed liquor that is uniformly mixed；The addition of its 5 FU 5 fluorouracil is the quality and concentration according to 5 FU 5 fluorouracil
Ratio for the gross mass of the plga and pcl solute in the solution of 15%w/v to add 5 FU 5 fluorouracil for 5%；
(4) prepare two-layer compound overlay film: the mixed liquor injection many spinning heads Static Spinning mixing that step (3) is obtained
In the syringe of silk machine, add the stainless steel syringe needle of a diameter of 0.5mm, the recovery obtaining with step (2) in the front end of syringe
Ni-ti memory Esophageal Stent to original length is rotating receiver；It is 20kv in voltage, solution flow rate is 5ml/h, rotation connects
Receive device apart from stainless steel syringe needle be 25cm under conditions of carry out electrostatic spinning, thus ni-ti remember Esophageal Stent surface obtain
The two-layer compound constituting to the tunica fibrosa being contained plga, pcl and 5 FU 5 fluorouracil by internal layer polycaprolactone dense film and outer layer is covered
Film, and the thickness of outer layer fiber film is about 100 μm；It is dried 48 hours in room temperature in vacuo, remove the organic solvent of residual, had
There is the Esophageal Stent of the two-layer compound overlay film of auxiliary treatment cancer of the esophagus function.The bilayer that this has auxiliary treatment cancer of the esophagus function is multiple
The Esophageal Stent closing overlay film preserves in 4 DEG C of drying boxes.
Embodiment 5
(1) polycaprolactone (pcl, weight average molecular weight is 200,000) internal layer coating solution is prepared in preparation: pcl is dissolved in oxolane
In, it is configured to the solution that concentration is 12%w/v, be stirred at room temperature 3 hours about；
(2) prepare internal layer pcl dense film: the solution that step (1) is obtained falls in culture dish, by the ni-ti note of compression
Recall Esophageal Stent and be placed in rolling in this culture dish, until the surface that pcl solution remembers Esophageal Stent in the ni-ti of this compression is uniform
Cover, take out and discharge the ni-ti memory Esophageal Stent of this compression, so that the ni-ti memory Esophageal Stent of compression is returned to original
Length, the surface remembering Esophageal Stent in ni-ti obtains the internal layer polycaprolactone dense film that thickness is about 30 μm；
(3) mixed liquor of outer layer fiber film is prepared in preparation: plga (weight average molecular weight is 150,000) is dissolved in hexafluoro isopropyl
In alcohol, it is configured to the solution that concentration is 12%w/v, adds taxol, be stirred at room temperature 12 hours about, be uniformly mixed is mixed
Close liquid；The addition of its taxol is the matter that quality and concentration according to taxol is the plga solute in the solution of 12%w/v
The ratio of amount to add taxol for 10%；
(4) prepare two-layer compound overlay film: the mixed liquor injection many spinning heads Static Spinning mixing that step (3) is obtained
In the syringe of silk machine, add the stainless steel syringe needle of a diameter of 0.5mm, the recovery obtaining with step (2) in the front end of syringe
Ni-ti memory Esophageal Stent to original length is rotating receiver；It is 20kv in voltage, solution flow rate is 5ml/h, rotation connects
Receive device apart from stainless steel syringe needle be 20cm under conditions of carry out electrostatic spinning, thus ni-ti remember Esophageal Stent surface obtain
The two-layer compound overlay film constituting to the tunica fibrosa being contained plga and taxol by internal layer pcl dense film and outer layer, and outer layer fiber
The thickness of film is about 150 μm；It is dried 26 hours in room temperature in vacuo, removes the organic solvent of residual, obtain eating with auxiliary treatment
The Esophageal Stent of the two-layer compound overlay film of pipe cancer function.This has the oesophagus of the two-layer compound overlay film of auxiliary treatment cancer of the esophagus function
Support preserves in 4 DEG C of drying boxes.
Claims (9)
1. a kind of preparation method of the Esophageal Stent of two-layer compound overlay film with auxiliary treatment cancer of the esophagus function, is characterized in that,
Described preparation method comprises the steps:
(1) polycaprolactone internal layer coating solution is prepared in preparation: polycaprolactone is dissolved in organic solvent, be configured to concentration be 10～
The solution of 20%w/v, is stirred at room temperature uniformly；
(2) prepare internal layer polycaprolactone dense film: the solution that step (1) is obtained falls in culture dish, by the ni-ti note of compression
Recall Esophageal Stent and be placed in rolling in this culture dish, until polycaprolactone solution remembers the table of Esophageal Stent in the ni-ti of this compression
Face uniform fold；Discharge the ni-ti memory Esophageal Stent of this compression, so that the ni-ti memory Esophageal Stent of compression is returned to original
Length, the surface remembering Esophageal Stent in ni-ti obtains internal layer polycaprolactone dense film；
(3) mixed liquor of outer layer fiber film is prepared in preparation: high-molecular organic material is dissolved in organic solvent, is configured to concentration
Solution for 9～15%w/v, adds cancer therapy drug, is stirred at room temperature uniformly, obtains mixed liquor；
(4) prepare two-layer compound overlay film: the mixed liquor that step (3) is obtained injects in the syringe of electrospinning device, in note
The front end of emitter adds the stainless steel syringe needle of a diameter of 0.3～0.7mm, the ni- returning to original length obtaining with step (2)
Ti memory Esophageal Stent is rotating receiver；It is 12～25kv in voltage, solution flow rate is 3～8ml/h, rotating receiver distance
Stainless steel syringe needle carries out electrostatic spinning under conditions of 10～25cm, and the surface remembering Esophageal Stent in ni-ti obtains by internal layer
The two-layer compound overlay film that the tunica fibrosa that polycaprolactone dense film and outer layer contain high-molecular organic material and cancer therapy drug is constituted；?
Room temperature in vacuo is dried, and removes the organic solvent of residual, obtains the food with the two-layer compound overlay film of auxiliary treatment cancer of the esophagus function
Pipe holder；
Described organic solvent be selected from dmf, acetone, trifluoroethanol, hexafluoroisopropanol, oxolane, chloroform, dichloromethane, two
One of methyl sulfoxide or two kinds.
2. preparation method according to claim 1, is characterized in that: the addition cancer therapy drug described in step (3), its anticarcinogen
The addition of thing is the matter that quality and concentration according to cancer therapy drug is the high-molecular organic material in the solution of 9～15%w/v
Amount ratio to add cancer therapy drug for 3～15%.
3. preparation method according to claim 1, is characterized in that: the thickness of the outer layer fiber film of described two-layer compound overlay film
Spend for 30～150 μm.
4. preparation method according to claim 1, is characterized in that: the internal layer polycaprolactone of described two-layer compound overlay film causes
The thickness of close film is 10～80 μm.
5. preparation method according to claim 1 and 2, is characterized in that: described high-molecular organic material is selected from lactic acid-hydroxyl
One or more of acetic acid copolymer, polycaprolactone, gelatin.
6. preparation method according to claim 1, is characterized in that: the weight average molecular weight of described polycaprolactone is 50,000～
200000.
7. preparation method according to claim 5, is characterized in that: the weight average molecular weight of described polycaprolactone is 50,000～
200000.
8. preparation method according to claim 5, is characterized in that: the weight average of described poly lactic coglycolic acid divides
Son amount is 50,000～200,000.
9. preparation method according to claim 1 and 2, is characterized in that: described cancer therapy drug is selected from taxol, Ah mould
One of element, 5 FU 5 fluorouracil.
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| CN201410640182.9A CN104474595B (en) | 2014-11-13 | 2014-11-13 | Production method of dilayer compounding coated esophageal stent with esophageal cancer treatment assisting function |
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Cited By (1)
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|---|---|---|---|---|
| WO2019136490A1 (en) * | 2018-01-08 | 2019-07-11 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
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| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| CA3078555A1 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | Implantable depots for the controlled release of therapeutic agents |
| CN110841116B (en) * | 2019-11-29 | 2022-01-07 | 深圳大学 | Focus in-situ drug controlled release system and preparation method thereof |
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| CN1305449C (en) * | 2003-12-25 | 2007-03-21 | 傅剑华 | Improved medical rack in cavity |
| US20070173787A1 (en) * | 2005-11-01 | 2007-07-26 | Huang Mark C T | Thin-film nitinol based drug eluting stent |
| CN201316331Y (en) * | 2008-10-15 | 2009-09-30 | 周星 | Biologically induced composite artificial esophagus |
| CN102078643A (en) * | 2010-12-21 | 2011-06-01 | 苏州同科生物材料有限公司 | Film coating method of self-expanding stent |
| CN102772831A (en) * | 2012-08-20 | 2012-11-14 | 道淼科技(北京)有限公司 | Degradable drug loading stent |
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| WO2019136490A1 (en) * | 2018-01-08 | 2019-07-11 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
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