CN104474435A - 一种用于治疗口臭的中药组合物及其制备方法 - Google Patents

一种用于治疗口臭的中药组合物及其制备方法 Download PDF

Info

Publication number
CN104474435A
CN104474435A CN201410668736.6A CN201410668736A CN104474435A CN 104474435 A CN104474435 A CN 104474435A CN 201410668736 A CN201410668736 A CN 201410668736A CN 104474435 A CN104474435 A CN 104474435A
Authority
CN
China
Prior art keywords
parts
radix
chinese medicine
medicine composition
halitosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410668736.6A
Other languages
English (en)
Inventor
孙丰卿
于春洋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201410668736.6A priority Critical patent/CN104474435A/zh
Publication of CN104474435A publication Critical patent/CN104474435A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739—Sanguisorba (burnet)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

一种用于治疗口臭的中药组合物，由：金银花18-22份、蒲公英18-22份、地榆28-32份、黄芩13-17份、赤芍18-22份、当归18-22份、五倍子28-32份、红花13-17份、茜草13-17份、葛根18-22份、藿香18-22份、木香18-22份、公丁香18-22份、草豆蔻18-22份、细辛2-4份、白芷18-22份制成，所述中药组合物药物剂型为：含漱剂、颗粒剂、水丸剂、蜜丸剂、片剂、胶囊剂或散剂。采用本发明治疗口臭，无副作用，效果显著。优点在于直接针对病因起效，无内服药的毒副作用，取得了满意治疗效果。

Description

一种用于治疗口臭的中药组合物及其制备方法
技术领域
本发明涉及一种用于治疗口臭的中药组合物及其制备方法，属于中医药领域。
背景技术
口气是指从口腔或其他充满空气的空腔中如鼻、鼻窦、咽，所散发出的臭气，它严重影响人们的社会交往和心理健康，WHO已将口臭作为一种疾病来进行报道。调查显示，中国口臭患病率为27.5％。而在西方国家，则为50％。全球约有10％～65％的人曾患有口臭。导致口臭的主要原因是口腔局部疾患，口臭也常是某些严重***性疾病的口腔表现，80％～90％的口臭是来源于口腔。口腔中有未治疗的龋齿、残根、残冠、不良修复体、不正常解剖结构、牙龈炎、牙周炎及口腔粘膜病等都可以引起口臭。其中龋齿和牙周疾病又是最常见的相关疾病。深龋窝洞内、不良修复体悬突下常残存食物残渣和菌斑，细菌经过发酵分解，产生臭味。牙髓坏死或化脓性牙髓炎，未经治疗也可发出臭味；牙周病患者常伴有大量的牙石、菌斑，牙周袋内细菌发酵产生硫化氢、吲哚和氨类，因而产生臭味，牙周脓肿和牙周袋溢脓，多为金黄色葡萄球菌合并牙周致病菌感染，也会发出臭味。唾液量的减少、蛋白质等有机成分的增多降低了唾液的冲刷作用和缓冲作用，使细菌大量繁殖，分解唾液、龈沟液及食物残渣中的有机成分，产生大量的挥发性硫化物、吲哚等物质，引起口臭。
口腔邻近组织疾病如化脓性扁桃体炎、慢性上颌窦炎、萎缩性鼻炎等，可产生脓性分泌物而发出臭味；临床上常见的内科疾病如急慢性胃炎、消化性溃疡出现酸臭味；幽门梗阻、晚期胃癌常出现臭鸭蛋性口臭；糖尿病酮症酸中毒患者可呼出丙酮味气体，***患者呼出烂苹果气味。另外白血病、维生素缺乏、重金属中毒等疾病均可引起的口臭。
口臭的治疗多常用漱口水包括洗必太、含氯化合物、过氧化氢、钠盐、锌盐等，但是效果欠佳，采用本发明治疗口臭，无副作用，，效果显著。优点在于直接针对病因起效，无内服药的毒副作用，取得了满意治疗效果。
发明内容
本发明要解决的问题是针对以上不足，提供一种用于治疗口臭的中药组合物及其制备方法。
本发明的技术方案是：
一种用于治疗口臭的中药组合物，由以下重量份的原材料制成：
金银花18-22份、蒲公英18-22份、地榆28-32份、黄芩13-17份、赤芍18-22份、当归18-22份、五倍子28-32份、红花13-17份、茜草13-17份、葛根18-22份、藿香18-22份、木香18-22份、公丁香18-22份、草豆蔻18-22份、细辛2-4份、白芷18-22份。
作为上述技术方案的进一步优选，所述中药组合物由以下重量份的原材料制成：
金银花20份、蒲公英20份、地榆30份、黄芩15份、赤芍20份、当归20份、五倍子30份、红花15份、茜草15份、葛根20份、藿香20份、木香20份、公丁香20份、草豆蔻20份、细辛3份、白芷20份。
根据本发明，一种治疗口臭的中药组合物的制备方法，包括以下步骤：
所述中药制剂的制备方法包括以下步骤：
；a、将金银花，蒲公英，地榆，黄芩，赤芍，当归，五倍子，红花，茜草，葛根，藿香，木香，公丁香，草豆蔻，细辛和白芷混合粉碎，加5-6倍量体积的75％乙醇回流1-2小时，过滤，取滤液，滤渣重复回流提取2-3次，合并滤液，乙醇回收；
b、将步骤a所得滤液混合均匀浓缩至80℃测得相对密度1.21～1.25稠浸膏；得膏剂；
c、将步骤c的稠浸膏，移进烘箱，50-70℃烘干至水分低于5％，研磨，得到药物粉剂；
d、将步骤e的药物粉剂中加入辅料，按现有技术制成颗粒剂、水丸剂、蜜丸剂、片剂、胶囊剂或散剂。
根据本发明，一种治疗口臭的中药组合物的制备方法：按比例取各原料成分，混合，加水煎煮30分钟，按现有技术工艺制成含漱剂。
在以上原料中：
金银花，功能主治清热解毒，凉散风热。用于痈肿疔疮，喉痹，丹毒，热血毒痢，风热感冒，温病发热。主治外感风热、瘟病初起、疮疡疔毒、红肿热痛、便脓血等，外用治疗痈疖脓肿，外伤感染，舌面溃疡，湿疹等。
蒲公英，功能主治清热解毒，消肿散结，利尿通淋。用于乳痈、瘰疬、疔疮肿毒、咽痛、肺痈、肠痈、目赤、湿热黄疸、热淋涩痛。外用治疗乳痈、疔疮肿毒，瘰历痰核，
五倍子，敛肺，涩肠，止血，解毒。治肺虚久咳，久痢。久泻，目汗，盗汗，遗精，便血，衄血，崩漏，，睫毛倒卷。外用治疗外伤出血，肿毒，疮疖，脱肛，眼赤湿烂，消肿毒、敛溃疮、金疮，收脱肛、子肠坠下，火伤及烫伤。
地榆，功能主治凉血止血，清热解毒。治吐血，衄血，血痢，崩漏，肠风，痔漏，无名肿毒，疖肿，痈肿，深部脓肿，湿疹，金疮，烧伤。外用治疗痔漏，痈肿，湿疹，外伤出血，烧伤
黄芩清热燥湿，泻火解毒，止血，安胎。用于：湿温、暑温胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。
赤芍，功效凉血活血，消肿止痛，主治瘀滞经闭，疝瘕积聚，腹痛，胁痛，衄血，血痢，肠风下血，目赤，痈肿。外用治疗痈肿，肠风下血痔瘘、发背、疮疥
当归，补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、***、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。外用治疗跌扑损伤、痈疽疮疡，
红花，功能活血通径、散瘀止痛。用于经闭、痛经、恶露不行、症瘕痞块、跌打损伤。适用各种静脉曲张，末梢神经炎，治经闭，癥瘕，难产，死胎，产后恶露不行、瘀血作痛，痈肿，跌扑损伤。外用治疗痈肿，跌扑损伤，褥疮
茜草，凉血止血，活血祛瘀，通经。用于吐血、衄血、崩漏下血、外伤出血、经闭瘀阻、关节痹痛、跌扑肿痛。本品止血而不留瘀，用于热证出血、经闭腹痛、跌打损伤。外用治疗跌打损伤肿痛，肠风痔瘘，疮疖，扑损瘀血
葛根：功效：解肌退热透疹生津止渴升阳止泻、主要应用于：表症发热项背强痛麻疹不透热病口渴阴虚消渴热泻热痢脾虚泄泻
藿香功效：化湿和中，解表、解署。主治湿阻脾胃，胸脘闷胀，食欲不香，恶心、呕吐；夏季暑湿困倦，胸闷不舒，以及外感风寒.恶寒胸闷等病症
木香行气止痛；调中导滞。主治胞胁胀满足，脘腹胀痛，哎吐泄泻，痢疾后重。
公丁香温中降逆，止痛，温肾助阳。主治脘腹冷痛，呃逆、呕吐、泄泻、肾虚阳痿，腰膝酸冷，阴疽。
草豆蔻功用主治温中，祛寒，行气，燥湿。治心腹冷痛，痞满食滞，噎膈反胃，寒湿吐泻，痰饮积聚。
燥湿健脾，温胃止呕。用于寒湿内阻、脘腹胀满冷痛、嗳气呕逆、不思饮食。
细辛功能主治：祛风，散寒，行水，开窍。治风冷头痛，鼻渊，齿痛，痰饮咳逆，风湿痹痛。
白芷功能主治祛风，燥湿，消肿，止痛。治头痛，眉棱骨痛，齿痛，鼻渊，寒湿腹痛，肠风痔漏，赤白带下，痈疽疮疡，皮肤燥痒，疥癣。
本发明采用以上技术方案，与现有技术相比，具有以下优点：本发明君、臣、佐、使各施其效，具有用药少，见效快，无副作用，可达到内外并施，标本兼顾的目的。对口臭疗效颇佳，可长期服用，且原材料价格便宜，操作简单，治疗效果好，值得推广应用。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1：一种用于治疗口臭的中药组合物，原材料重量份为：
金银花20份、蒲公英20份、地榆30份、黄芩15份、赤芍20份、当归20份、五倍子30份、红花15份、茜草15份、葛根20份、藿香20份、木香20份、公丁香20份、草豆蔻20份、细辛3份、白芷20份。
实施例2：一种用于治疗口臭的中药组合物，原材料重量份为：
金银花18份、蒲公英18份、地榆28份、黄芩13份、赤芍18份、当归18份、五倍子28份、红花13份、茜草13份、葛根18份、藿香18份、木香18份、公丁香18份、草豆蔻18份、细辛2份、白芷18份。
实施例3：一种用于治疗口臭的中药组合物，原材料重量份
金银花22份、蒲公英22份、地榆32份、黄芩17份、赤芍22份、当归22份、五倍子32份、红花17份、茜草17份、葛根22份、藿香22份、木香22份、公丁香22份、草豆蔻22份、细辛4份、白芷22份。
实施例4：以上实施例1-3的药物按照以下步骤制备成不同的剂型：含漱剂、颗粒剂、水丸剂、蜜丸剂、片剂、胶囊剂或散剂。
a、将金银花，蒲公英，地榆，黄芩，赤芍，当归，五倍子，红花，茜草，葛根，藿香，木香，公丁香，草豆蔻，细辛和白芷混合粉碎，加5-6倍量体积的75％乙醇回流1-2小时，过滤，取滤液，滤渣重复回流提取2-3次，合并滤液，乙醇回收；
b、将步骤a所得滤液混合均匀浓缩至80℃测得相对密度1.21～1.25稠浸膏；得膏剂；
c、将步骤c的稠浸膏，移进烘箱，50-70℃烘干至水分低于5％，研磨，得到药物粉剂；
d、将步骤e的药物粉剂中加入辅料，按现有技术制成颗粒剂、水丸剂、蜜丸剂、片剂、胶囊剂或散剂。
根据本发明，一种治疗口臭的中药组合物的制备方法：按比例取各原料成分，混合，加水煎煮30分钟，制成含漱剂。
选取400例口臭患者，随机选取300例作为治疗组，另外100例作为对照组，其中300例患者分为治疗组1、治疗组2和治疗组3，每个治疗组治疗随机选取的100例患者，治疗组1使用本发明实施例1的含漱剂进行治疗，治疗组2使用本发明实施例2的含漱剂进行治疗，治疗组3使用本发明实施例3的含漱剂治疗
对照组的患者采用含氯化合物漱口水。
治疗结果如下表：
从以上数据表可以看出，治疗组有效率治愈率明显高于对照组，治疗组3的治愈率有效率高于其余治疗组1和治疗组2，综上所述治疗组3组方最为有效。

Claims (4)

1.一种用于治疗口臭的中药组合物，由以下重量份的原材料制成：
金银花18-22份、蒲公英18-22份、地榆28-32份、黄芩13-17份、赤芍18-22份、当归18-22份、五倍子28-32份、红花13-17份、茜草13-17份、葛根18-22份、藿香18-22份、木香1822份、公丁香18-22份、草豆蔻18-22份、细辛2-4份、白芷18-22份。
2.如权利要求1所述的一种用于治疗口臭的中药组合物，由以下重量份的原材料制成：
金银花20份、蒲公英20份、地榆30份、黄芩15份、赤芍20份、当归20份、五倍子30份、红花15份、茜草15份、葛根20份、藿香20份、木香20份、公丁香20份、草豆蔻20份、细辛3份、白芷20份。
3.制备如权利要求1或2所述的用于治疗口臭的中药组合物的方法，包括以下步骤：
a、将金银花，蒲公英，地榆，黄芩，赤芍，当归，五倍子，红花，茜草，葛根，藿香，木香，公丁香，草豆蔻，细辛和白芷混合粉碎，加5-6倍量体积的75％乙醇回流1-2小时，过滤，取滤液，滤渣重复回流提取2-3次，合并滤液，乙醇回收；
b、将步骤a所得滤液混合均匀浓缩至80℃测得相对密度1.21～1.25稠浸膏；得膏剂；
c、将步骤c的稠浸膏，移进烘箱，50-70℃烘干至水分低于5％，研磨，得到药物粉剂；
d、将步骤e的药物粉剂中加入辅料，按现有技术制成颗粒剂、水丸剂、蜜丸剂、片剂、胶囊剂或散剂。
4.制备如权利要求1或2所述的用于治疗口臭的中药组合物的方法：包括将按比例取各原料成分，混合，加水煎煮30分钟，按现有技术工艺制成含漱剂。
CN201410668736.6A 2014-11-16 2014-11-16 一种用于治疗口臭的中药组合物及其制备方法 Pending CN104474435A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410668736.6A CN104474435A (zh) 2014-11-16 2014-11-16 一种用于治疗口臭的中药组合物及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410668736.6A CN104474435A (zh) 2014-11-16 2014-11-16 一种用于治疗口臭的中药组合物及其制备方法

Publications (1)

Publication Number Publication Date
CN104474435A true CN104474435A (zh) 2015-04-01

Family

ID=52749136

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410668736.6A Pending CN104474435A (zh) 2014-11-16 2014-11-16 一种用于治疗口臭的中药组合物及其制备方法

Country Status (1)

Country Link
CN (1) CN104474435A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116688012A (zh) * 2023-07-05 2023-09-05 浙江工业大学 一种预防流感的***片

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1415227A (zh) * 2002-09-24 2003-05-07 蒋兴民 体香糖
CN101181360A (zh) * 2007-11-26 2008-05-21 于世鹏 一种治疗口臭的漱口药剂
CN102068499A (zh) * 2011-01-18 2011-05-25 夏运喜 一种含服祛除口腔异味的中药及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1415227A (zh) * 2002-09-24 2003-05-07 蒋兴民 体香糖
CN101181360A (zh) * 2007-11-26 2008-05-21 于世鹏 一种治疗口臭的漱口药剂
CN102068499A (zh) * 2011-01-18 2011-05-25 夏运喜 一种含服祛除口腔异味的中药及其制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116688012A (zh) * 2023-07-05 2023-09-05 浙江工业大学 一种预防流感的***片
CN116688012B (zh) * 2023-07-05 2024-06-04 浙江工业大学 一种预防流感的***片

Similar Documents

Publication Publication Date Title
CN101912468A (zh) 治疗乳腺炎的中草药
CN103271230A (zh) 猪用促生长的中药饲料及其制备方法和应用
CN102526280B (zh) 一种治疗口腔溃疡的中药组合物
CN103705685B (zh) 一种治疗产后缺乳的中药制剂
CN104274649B (zh) 一种用于口腔溃疡的药物
CN103816366B (zh) 一种治疗口腔溃疡的药物
CN104474435A (zh) 一种用于治疗口臭的中药组合物及其制备方法
CN105267678B (zh) 用于颌骨骨髓炎的中药组合物
CN104208621A (zh) 一种治疗麦粒肿的中药
CN107789519A (zh) 一种治疗口臭的中药组合物及制备方法
CN104288379B (zh) 一种治疗口腔溃疡的中药组合物
CN103623335B (zh) 一种治疗鼻炎的中药制剂
CN109700995B (zh) 一种治疗消化性溃疡的药物组合物及其制备方法
CN103432422B (zh) 一种治疗慢性胃炎的中药
CN101129875A (zh) 一种治疗***的中药组合物
CN104998189A (zh) 一种治疗风热乘脾型小儿口疮的中药散剂及其制备方法
CN105056065A (zh) 一种治疗咽喉炎的中药组合物
CN105055653A (zh) 一种治疗牙髓炎病的汤剂药物及其制备方法
CN104906352A (zh) 一种治疗虚火上炎型小儿口疮的中药药液及其制备方法
CN104491391A (zh) 一种治疗咽炎的中药组合物
CN104784438A (zh) 治疗***炎的中药剂及制法
CN104258177A (zh) 一种治疗肺脓肿的中药
CN104288675A (zh) 一种防治甲型肝炎的中药配方及其制备方法
CN103638410A (zh) 一种治疗牙周炎的内服汤剂
CN100364576C (zh) 治疗妇女带下量多、***的***用中药制剂及其生产方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20150401