CN104474022A - Traditional Chinese medicine composition for treating hepatitis - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hepatitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the raw materials consisting of the following traditional Chinese medicine ingredients in parts by weight: 15-50 parts of cudrania cochinchinensis, 10-30 parts of centella asiatica, 10-30 parts of hypericum japonicum, 8-20 parts of herba artemisiae scopariae, 10-20 parts of scutellaria baicalensis Georgi, 10-20 parts of lycopus lucidus, 10-30 parts of pueraria lobata and 3-8 parts of glycyrrhiza uralensis. The traditional Chinese medicine composition can be used for obviously improving the symptoms, such as jaundice, anorexia, nausea, epigastric discomfort, hepatic region pain and asthenia, of hepatitis patients, has the effects of clearing away heat and toxic materials and inducing diuresis and treating jaundice, and can also be used for improving the resistance of the patients. The traditional Chinese medicine composition is rigorous in formula, small in number of medicines and special in effect, and has a good treatment effect on hepatitis.
Description
Technical field
The invention belongs to medicine field, relate to a kind of Chinese medicine composition for the treatment of hepatitis.
Background technology
Hepatitis is the general designation of inflammation, typically refer to by multiple paathogenic factor: as virus, antibacterial, parasite, chemical toxicant, medicine, ethanol, role of autoimmune factors etc. make liver cell be damaged, the function of liver suffers damage, cause a series of malaise symptoms of health, and the exception of liver function index.Said hepatitis in our life, majority refers to the viral hepatitis caused by hepatitis viruss such as A type, B-mode, the third types, is characterized in: route of transmission complicated, popular wide, sickness rate is high.Chinese medicine from entirety in treatment hepatitis, is transferred the immunologic function of whole body system, is had good curative effect.The present invention is the Traditional Chinese medicine composition formula of " Radix Cudraniae ", starts with, activate hepatocyte cambium from sterilization diuresis, repair Liver immunity function, building up resistance, is suit the remedy to the case according to etiopathogenesis, have no side effect, can symptom management effectively after taking medicine, there is therapeutical effect to hepatitis.
(1) Radix Cudraniae is the dry root of Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudrania cochin chinensis (Lour.) Kudo et Masam..[nature and flavor] micro-hardship, flat.[function with cure mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain.For pulmonary tuberculosis, icterohepatitis, hepatosplenomegaly, taste-blindness rate, rheumatic lumbago and scelalgia; Fracture is controlled in external, traumatic injury.
(2) Herba Centellae is the dry herb of samphire Herba Centellae Centella asiatica (L.) Urb..[nature and flavor with return through] bitter, acrid, cold.Return liver,spleen,kidney warp.[function with cure mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, stranguria caused by urinary stone stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
(3) Herba Hyperici Japonici is Hypericaceae hypericum
herba Hyperici Japonicithe dry herb of Hypericum japonicum Thunb..[nature and flavor] sweet, micro-hardship, cool.[function with cure mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For hepatitis, early stage liver cirrhosis, appendicitis, eye conjunctivitis, tonsillitis; Furuncle toxic swelling is controlled in external, herpes zoster, venom, traumatic injury.
(4) Herba Artemisiae Scopariae is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparza Waldst.et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..[nature and flavor with return through] are bitter, pungent, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.[function with cure mainly] eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.For jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
(5) Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.[nature and flavor with return through] are bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.[function with cure mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst. heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
(6) Herba Lycopi is the dry aerial parts of labiate hair leaf lycopus lucidus Lycopus lucidus Turcz.vat.hirtus Regel.[nature and flavor with return through] are bitter, pungent, tepor.Return liver, spleen channel.[function with cure mainly] promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, inducing diuresis to remove edema.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, sore and toxic, edema ascites.
(7) Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) ohwi.[nature and flavor with return through] are sweet, pungent, cool.Return spleen, stomach, lung meridian.[function with cure mainly] expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.
(8) Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.[function with cure mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of hepatitis and preparation method thereof, this Chinese medicine composition has heat-clearing and toxic substances removing, dampness removing jaundice eliminating effect, effectively can treat hepatitis.
The technical solution adopted in the present invention is as follows:
Treat a Chinese medicine composition for hepatitis, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 15-50 part, Herba Centellae 10-30 part, Herba Hyperici Japonici 10-30 part, Herba Artemisiae Scopariae 8-20 part, Radix Scutellariae 10-20 part, Herba Lycopi 10-20 part, Radix Puerariae 10-30 part, Radix Glycyrrhizae 3-8 part.
The Chinese medicine composition of the above treatment hepatitis, raw material is preferably made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 25-40 part, Herba Centellae 15-25 part, Herba Hyperici Japonici 15-25 part, Herba Artemisiae Scopariae 10-18 part, Radix Scutellariae 15-20 part, Herba Lycopi 10-15 part, Radix Puerariae 15-25 part, Radix Glycyrrhizae 4-6 part, and the best is preferably made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 30 parts, Herba Centellae 20 parts, Herba Hyperici Japonici 20 parts, Herba Artemisiae Scopariae 15 parts, Radix Scutellariae 18 parts, Herba Lycopi 12 parts, Radix Puerariae 20 parts, 5 parts, Radix Glycyrrhizae.
The Chinese medicine composition of above-described treatment hepatitis, can be prepared into pharmaceutically acceptable any dosage form, as: powder, granule (electuary), pill, tablet, capsule, decoction, mixture (comprising oral liquid), syrup etc.As preferably, described dosage form is pill.
The Chinese medicine composition of the above treatment hepatitis makes the preparation method of pill, comprises the following steps:
1. get Radix Cudraniae, Herba Centellae, Herba Hyperici Japonici, Herba Artemisiae Scopariae, Radix Scutellariae, Herba Lycopi, Radix Puerariae, Radix Glycyrrhizae respectively, clean, dry;
2. take by weight: Radix Cudraniae 15-50 part, Herba Centellae 10-30 part, Herba Hyperici Japonici 10-30 part, Herba Artemisiae Scopariae 8-20 part, Radix Scutellariae 10-20 part, Herba Lycopi 10-20 part, Radix Puerariae 10-30 part, Radix Glycyrrhizae 3-8 part;
3. load weighted Chinese medicine is beaten powder, cross 80 mesh sieves, sterilizing;
4. the medicated powder that sterilizing is good is added appropriate refined honey, mixing, makes pill, to obtain final product.
The above preparation method technique is simple, and can remain the effective ingredient in medical material completely, and the efficacy of a drug is lasting, and be convenient to take, mouthfeel is good.
The present invention is on the basis of Chinese medicine traditional theory, in conjunction with medication experience among the people, uses modern scientific theory formulated.Radix Cudraniae in side, has heat-clearing and toxic substances removing, expelling wind and removing dampness, effect of eliminating stasis to stop pain, is monarch drug.Herba Centellae has clearing away heat-damp and promoting diuresis, the merit of removing toxic substances and promoting subsidence of swelling; Herba Hyperici Japonici has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, the merit of eliminating stasis to stop pain; Herba Artemisiae Scopariae has eliminating damp-heat, the merit of promoting the function of the gallbladder to alleviate jaundice; Radix Scutellariae has heat clearing and damp drying, being total to of eliminating fire and detoxication; Be ministerial drug altogether.Herba Lycopi has the merit of blood stasis dispelling eliminating carbuncle, inducing diuresis to remove edema, and Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, the merit of alcoholic intoxication; The two is combined into adjuvant drug.Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the merit of coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share the merit of playing heat-clearing and toxic substances removing, dampness removing jaundice eliminating altogether, obviously can improve patient's jaundice, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the symptom such as weak, the resistance of patient can also be improved.Prescription of the present invention is rigorous, parum drug and centralize the power, has good curative effect to hepatitis.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
The Chinese medicine composition of one, treating hepatitis makes the preparation method of pill
1. EXPERIMENTAL DESIGN:
This test 5 embodiments are prepared into pill respectively, and design parameter refers to table 1.
Table 1 embodiment preparation parameter table
Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
Radix Cudraniae (kg) | 15 | 25 | 40 | 50 | 30 |
Herba Centellae (kg) | 10 | 15 | 25 | 30 | 20 |
Herba Hyperici Japonici (kg) | 10 | 15 | 25 | 30 | 20 |
Herba Artemisiae Scopariae (kg) | 8 | 10 | 18 | 20 | 15 |
Radix Scutellariae (kg) | 10 | 15 | 18 | 20 | 16 |
Herba Lycopi (kg) | 10 | 12 | 15 | 20 | 13 |
Radix Puerariae (kg) | 10 | 15 | 25 | 30 | 20 |
Radix Glycyrrhizae (kg) | 3 | 4 | 6 | 8 | 5 |
Sterilization time (h) | 10 | 10 | 20 | 15 | 15 |
Forming agent | Refined honey | Refined honey | Refined honey | Refined honey | Refined honey |
2. operating procedure:
(1) get Radix Cudraniae, Herba Centellae, Herba Hyperici Japonici, Herba Artemisiae Scopariae, Radix Scutellariae, Herba Lycopi, Radix Puerariae, Radix Glycyrrhizae respectively, clean, dry;
(2) take by table 1 weight portion: Radix Cudraniae, Herba Centellae, Herba Hyperici Japonici, Herba Artemisiae Scopariae, Radix Scutellariae, Herba Lycopi, Radix Puerariae, Radix Glycyrrhizae;
(3) load weighted Chinese medicine is beaten powder, cross 80 mesh sieves, put sterilizing in 100 DEG C of baking ovens according to table 1 time;
(4) medicated powder that sterilizing is good is added appropriate refined honey, mixing, makes pill.
Two, clinical practice
1. case selection standard
All cases all meet the viral hepatitis control prece of the tenth the national viral hepatitis control in Xi'an in 2000 and hepatopathy academic conference discussion revision " diagnostic criteria.
(1) clinical symptoms is: jaundice, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak; Liver obviously increases at no distant date, and with tenderness or button pain.
(2) Liver function grade is positive: alanine aminotransferase (ALT) > 80u/L, serum bilirubin > 34 μm of ol/L.
(3) patient did not take any medicine or poisonous substance that can produce jaundice in the recent period, and near over the past half year without injection blood plasma, serum or blood history.
Possess above three, the age is 15-70 year person simultaneously.
2. therapeutic scheme
(1) embodiment group: by above-mentioned embodiment 5 sample prepared, for clinical trial.Oral, one time 6,4 times on the one.The course for the treatment of: medication 1 month.
(2) matched group: the grand granule of sharp liver (commercially available).Oral, once a bag, 3 times on the one.The course for the treatment of: medication 1 month.
3. efficacy assessment standard
(1) fully recover: jaundice disappears, liver recovers normal size, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the main clinic symptoms such as weak disappear; Liver function recovery is normal.
(2) improve: jaundice goes down, liver recovers normal size or stablize constant, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the main clinic symptoms such as weak alleviate; Liver function grade: alanine aminotransferase (ALT): 40u/L < ALT ﹤ 80u/L, 17 μm of ol/L < serum bilirubin ﹤, 34 μm of ol/L.
4. result of the test: be used for the treatment of and observe 75 routine outpatients.By above-mentioned embodiment 5 sample for preparing and the grand granule of sharp liver, be respectively used to patient: treatment group: 45 examples (man 22 example, female 23 example, 38.1 years old mean age), matched group 30 example (man 13 example, female 17 example, 41.8 years old mean age), the results detailed in Table 2.
Table 2 clinical trial result table
Result shows: adopt the embodiment of the present invention 5 to treat, cure rate is 69%, effective percentage reaches 91%, general effect and matched group are suitable, do not have untoward reaction to occur, use safety, effective, obviously can improve patient's jaundice, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the symptom such as weak, there is heat-clearing and toxic substances removing, dampness removing jaundice eliminating effect, the resistance of patient can also be improved, favourable prognosis.Be below several model case:
Case 1: Rhizoma Zingiberis Recens ××, man, 38 years old, oil, loss of appetite, Nausea and vomiting, abdominal distention, weak, bitter taste, complexion jaundice were detested in readme, and with low grade fever, hospital's Liver function grade is positive.Take the embodiment of the present invention 5 sample, one time 6,4 times on the one, medication 1 month, above symptom is eliminated, and hospital carries out Liver function grade, and result is normal, recovery from illness.
Case 2: poplar ××, female, 39 years old, the decline of readme malaise, appetite, Nausea and vomiting, yellowish urine, detest greasy food, hospital's Liver function grade is positive.Take the embodiment of the present invention 5 sample, one time 6,4 times on the one, after serveing on 5, urine recovers normal, appetite increases, and continue medication 1 month, above symptom is eliminated, and hospital carries out Liver function grade, and result is normal, recovery from illness.
Case 3: Lee's ××, female, 35 years old, readme yellow urine, bitter taste, desire for cold drinks, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak, see the jaundice of its complexion, hospital's Liver function grade is positive.Take the embodiment of the present invention 5 sample, one time 6,4 times on the one, serve on 7, urine is normally unobstructed, and diet recovers, and without bitter taste sensation, continue medication 1 month, above symptom is eliminated, and hospital carries out Liver function grade, and result is normal, fully recovers.
Claims (6)
1. treat the Chinese medicine composition of hepatitis for one kind, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 15-50 part, Herba Centellae 10-30 part, Herba Hyperici Japonici 10-30 part, Herba Artemisiae Scopariae 8-20 part, Radix Scutellariae 10-20 part, Herba Lycopi 10-20 part, Radix Puerariae 10-30 part, Radix Glycyrrhizae 3-8 part.
2. treat the Chinese medicine composition of hepatitis according to claim 1, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 25-40 part, Herba Centellae 15-25 part, Herba Hyperici Japonici 15-25 part, Herba Artemisiae Scopariae 10-18 part, Radix Scutellariae 15-20 part, Herba Lycopi 10-15 part, Radix Puerariae 15-25 part, Radix Glycyrrhizae 4-6 part.
3. according to claim 1 or 2, treat the Chinese medicine composition of hepatitis, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 30 parts, Herba Centellae 20 parts, Herba Hyperici Japonici 20 parts, Herba Artemisiae Scopariae 15 parts, Radix Scutellariae 18 parts, Herba Lycopi 12 parts, Radix Puerariae 20 parts, 5 parts, Radix Glycyrrhizae.
4. according to claim 1 or 2, treat the Chinese medicine composition of hepatitis, it is characterized in that, described compositions is prepared into pharmaceutically acceptable any dosage form.
5. treat the Chinese medicine composition of hepatitis according to claim 4, it is characterized in that, described dosage form is pill.
6. the Chinese medicine composition for the treatment of hepatitis as claimed in claim 1 makes a preparation method for pill, it is characterized in that, comprises the following steps:
(1) get Radix Cudraniae, Herba Centellae, Herba Hyperici Japonici, Herba Artemisiae Scopariae, Radix Scutellariae, Herba Lycopi, Radix Puerariae, Radix Glycyrrhizae respectively, clean, dry;
(2) take by weight: Radix Cudraniae 15-50 part, Herba Centellae 10-30 part, Herba Hyperici Japonici 10-30 part, Herba Artemisiae Scopariae 8-20 part, Radix Scutellariae 10-20 part, Herba Lycopi 10-20 part, Radix Puerariae 10-30 part, Radix Glycyrrhizae 3-8 part;
(3) load weighted Chinese medicine is beaten powder, cross 80 mesh sieves, sterilizing;
(4) medicated powder that sterilizing is good is added appropriate refined honey, mixing, makes pill, to obtain final product.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104857362A (en) * | 2015-06-16 | 2015-08-26 | 潘剑崎 | Traditional Chinese medicine for treating jaundice |
CN105920456A (en) * | 2016-05-31 | 2016-09-07 | 安徽皖斛堂生物科技有限公司 | Dendrobium officinale granules dedicated to hepatitis |
CN105944035A (en) * | 2016-06-30 | 2016-09-21 | 仉海峰 | Traditional Chinese medicinal combination for treating hepatitis |
CN112568424A (en) * | 2019-09-30 | 2021-03-30 | 深圳市华韵生物科技产业有限公司 | Food for conditioning liver diseases |
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CN112568424A (en) * | 2019-09-30 | 2021-03-30 | 深圳市华韵生物科技产业有限公司 | Food for conditioning liver diseases |
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