CN104474015A - Medicine for lowering blood pressure and blood fat and preparation method of medicine - Google Patents
Medicine for lowering blood pressure and blood fat and preparation method of medicine Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a medicine for lowering blood pressure and blood fat and a preparation method of the medicine. The medicine is prepared from the following raw materials in parts by weight: 2-4 parts of prunella vulgaris, 2-4 parts of wild chrysanthemum flower, 2-4 parts of salviae miltiorrhizae, 2-4 parts of cordate telosma, 2-4 parts of semen cassia, 2-4 parts of astragalus membranaceus, 3-5 parts of eucommia ulmoides and 3-5 parts of radix puerariae. The method comprises the following steps: taking the raw materials according to the parts by weight; and cleaning, drying, crushing, decocting and concentrating, so as to obtain the medicine. The medicine disclosed by the invention is clinically applied to lowering blood pressure and blood fat, and has the characteristics of good curative effect and small side effect; through use of clinical 187 cases, the total effective rate is 89.3%, and the obvious effective rate is 77.5%; and medication is convenient and fast.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of medicine for blood fat-reducing blood pressure-decreasing, also relate to the preparation method of this medicine simultaneously.
Background technology
Human blood circulation is enclosed, is by the Two-way Cycle that body circulates and pulmonary circulation two approach are formed.Disturbance of blood circulation can cause numbness of hands and feet, confirmed fatigue, the dizzy symptom such as unable, further develops and patient may be made to be difficult to take care of oneself normally.Time serious, disturbance of blood circulation also may develop into the various diseases comprising hypertension, hyperlipidemia, arteriosclerosis etc.
Hypertension and hyperlipidemia are one of diseases that modern society's sickness rate is the highest, if the improper meeting of controlling of blood pressure causes liver, brain, kidney target organ function damage, cause irreversible serious consequence; It is improper that blood fat controls, and easily causes the serious consequence such as atherosclerosis, coronary heart disease.The measure of modern treatment hypertension and hyperlipidemia is a lot, in general first will carry out lifestyle modification, then carry out Drug therapy according to individual instances, and object is for control blood pressure and blood fat are within normal range.
Obviously, good blood circulation, is conducive to prophylaxis of hypertension and hyperlipidemia, plays auxiliary effect to the treatment of hypertension and hyperlipidemia, alleviates health and the mental anguish of patient.
At present, the medicine clinically for blood fat-reducing blood pressure-decreasing is more, comprises Chinese patent medicine and chemical drugs, but majority exists the problems such as side effect is large, use is inconvenient.
In crude drug used in the present invention, Spica Prunellae (
prunella vulgaris) be the dry fruit ear of labiate Spica Prunellae.Gingival hemorrhage can be controlled, have sore throat, hemorrhoid and menorrhagia etc., and have the effect of sterilization, convergence, promotion wound healing and blood pressure lowering.
Flos Chrysanthemi Indici (
dendranthema indicum) be the head inflorescence of Compositae herbaceos perennial Herba Dendranthematis indici.There is the effect of heat-clearing and toxic substances removing, treatment furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis can be widely used in, the disease such as dizzy of having a headache.There is again good hypotensive effect simultaneously, can be used for the auxiliary treatment of hypertension.
Radix Salviae Miltiorrhizae be labiate Radix Salviae Miltiorrhizae (
salvia miltiorrhiza Bge) dry root and rhizome.There is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, reduce blood pressure, calm the nerves with all worries set aside, blood sugar lowering and the effect such as antibacterial, modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment.
Radix Oenotherae erythrosepalae be asclepiadaceae tuberose plant Radix Oenotherae erythrosepalae (
telosma cordatum (Brum. f.) Merr), be used as medicine with leaf, flower, fruit.Liver heat removing, improving eyesight, removing nebula, removing toxic substances and promoting tissue regeneration.
Semen Cassiae be leguminous plant Semen Cassiae (
cassia obtusifolia L) and little Semen Cassiae (
cassia tora L) mature seed.Liver heat removing, improving eyesight, diuretic, relieving constipation.Cure mainly wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation.
The Radix Astragali be leguminous plant Mongolia yellow (
astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao) stilbene or Radix Astragali (
astragalus membranaceus (Fisch.) Bge) dry root.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
The Cortex Eucommiae be the Eucommiaceae plant Cortex Eucommiae (
eucommia ulmoides Oliv) bark.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension.
Radix Puerariae be legume pueraria lobata (
pueraria lobata(Willd.) Ohwi) or Radix Puerariae rattan (Pueraria thomsonii Benth) dry root.Expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, hypertension neck pain.
Summary of the invention
The object of the present invention is to provide the medicine for blood fat-reducing blood pressure-decreasing that a kind of good effect, side effect are little.
Another object of the present invention is to the preparation method of the medicine providing this for blood fat-reducing blood pressure-decreasing.
Medicine of the present invention is prepared by the crude drug of following weight proportion:
Spica Prunellae 2-4 part, Flos Chrysanthemi Indici 2-4 part, Radix Salviae Miltiorrhizae 2-4 part, Radix Oenotherae erythrosepalae 2-4 part, Semen Cassiae 2-4 part, Radix Astragali 2-4 part, Cortex Eucommiae 3-5 part, Radix Puerariae 3-5 part.
Medicine of the present invention can make lotion.
The preparation method of a kind of medicine for blood fat-reducing blood pressure-decreasing of the present invention, comprises following step:
(1) screen crude drug, sample by weight ratio, cleaning, oven dry, pulverizing;
(2) add crude drug 5.5-6.5 soak by water 2-2.5 hour doubly, filter, obtain filtrate for subsequent use;
(3) add medicinal residues 3.5-4.5 soak by water 1-1.5 hour doubly, filter, obtain filtrate;
(4) merge twice filtrate, be concentrated into relative density 1:1, leave standstill 24 hours, filter, filtrate gets final product subpackage.
The present invention compared with prior art, there is obvious beneficial effect, as can be known from the above technical solutions: the present invention selects Spica Prunellae, Herba Dendranthematis indici, Radix Salviae Miltiorrhizae, Radix Oenotherae erythrosepalae, Semen Cassiae, the Radix Astragali, the Cortex Eucommiae, Radix Puerariae to be raw material, come for blood fat-reducing blood pressure-decreasing by the synergism of each medicine, thus reach the object of assisting in treating hypertension, hyperlipidemia.Its expense is low, good effect, side effect are little, and medication is convenient and swift.Clinical 187 examples use, total effective rate 89.3%, obvious effective rate 77.5%.
Detailed description of the invention
the beneficial effect of medicine of the present invention is set forth further below by way of test example.
test example:the clinical observation of medicine of the present invention
Clinical data:
All cases 187 example, wherein male 116 example, women 71 example, max age 72 years old, minimum 31 years old, blood pressure peak 195/115mmhg, blood fat peak 269mg/dl.
Diagnostic criteria:
" disease of tcm Standardization of diagnosis and curative effect "
Therapeutic Method:
Patient body is made even position of lying, each with medicinal liquid and water in proportion 1:3 take a shower, heat and be down to 42 DEG C of maintenance 30nin again after 80 DEG C, once a day, a course for the treatment of on the 7th, the lighter 1-2 course for the treatment of, severe one 4-5 the course for the treatment of.
Criterion of therapeutical effect:
Effective: blood pressure blood fat is effectively regulated
Effective: blood pressure blood fat is adjusted
Invalid: symptom is without improvement or increase the weight of.
Therapeutic outcome:
187 routine patients are through Drug therapy of the present invention, and effective 145 examples, effective 22 examples, invalid 15 is routine, total effective rate 89.3%.
embodiment 1
For a medicine for blood fat-reducing blood pressure-decreasing, comprise the following steps:
(1) Spica Prunellae 0.4kg is taken, Flos Chrysanthemi Indici 0.4kg, Radix Salviae Miltiorrhizae 0.2kg, Radix Oenotherae erythrosepalae 0.2kg, Semen Cassiae 0.4kg, Radix Astragali 0.2kg, Cortex Eucommiae 0.3kg, Radix Puerariae 0.5kg, cleaning, oven dry, pulverizing;
(2) add the soak by water 2 hours of crude drug 6 times, filter, obtain filtrate for subsequent use;
(3) add the soak by water 1.5 hours of medicinal residues 4 times, filter, obtain filtrate;
(4) merge twice filtrate, be concentrated into relative density 1:1, leave standstill 24 hours, filter, filtrate gets final product subpackage.
embodiment 2
For a medicine for blood fat-reducing blood pressure-decreasing, comprise the following steps:
(1) Spica Prunellae 0.2kg is taken, Flos Chrysanthemi Indici 0.2kg, Radix Salviae Miltiorrhizae 0.4kg, Radix Oenotherae erythrosepalae 0.4kg, Semen Cassiae 0.2kg, Radix Astragali 0.4kg, Cortex Eucommiae 0.5kg, Radix Puerariae 0.3kg, cleaning, oven dry, pulverizing;
(2) add the soak by water 2.5 hours of crude drug 5.5 times, filter, obtain filtrate for subsequent use;
(3) add the soak by water 1 hour of medicinal residues 4.5 times, filter, obtain filtrate;
(4) merge twice filtrate, be concentrated into relative density 1:1, leave standstill 24 hours, filter, filtrate gets final product subpackage.
embodiment 3
For a medicine for blood fat-reducing blood pressure-decreasing, comprise the following steps:
(1) screen crude drug, sample by following weight proportion: Spica Prunellae 0.3kg, Flos Chrysanthemi Indici 0.3kg, Radix Salviae Miltiorrhizae 0.3kg, Radix Oenotherae erythrosepalae 0.3kg, Semen Cassiae 0.3kg, Radix Astragali 0.3kg, the Cortex Eucommiae 0. 4kg, Radix Puerariae 0.4kg, cleaning, oven dry, pulverizing;
(2) add the soak by water 2.25 hours of crude drug 6.5 times, filter, obtain filtrate for subsequent use;
(3) add the soak by water 1.25 hours of medicinal residues 3.5 times, filter, obtain filtrate;
(4) merge twice filtrate, be concentrated into relative density 1:1, leave standstill 24 hours, filter, filtrate gets final product subpackage.
Claims (3)
1. for a medicine for blood fat-reducing blood pressure-decreasing, be made up of the crude drug of following weight proportioning: Spica Prunellae 2-4 part, Flos Chrysanthemi Indici 2-4 part, Radix Salviae Miltiorrhizae 2-4 part, Radix Oenotherae erythrosepalae 2-4 part, Semen Cassiae 2-4 part, Radix Astragali 2-4 part, Cortex Eucommiae 3-5 part, Radix Puerariae 3-5 part.
2., as claimed in claim 1 for the medicine of blood fat-reducing blood pressure-decreasing, it is characterized in that: described medicine is lotion.
3., as claimed in claim 1 for the preparation method of the medicine of blood fat-reducing blood pressure-decreasing, comprise the following steps:
(1) screen crude drug, sample by weight ratio, cleaning, oven dry, pulverizing;
(2) add crude drug 5.5-6.5 soak by water 2-2.5 hour doubly, filter, obtain filtrate for subsequent use;
(3) add medicinal residues 3.5-4.5 soak by water 1-1.5 hour doubly, filter, obtain filtrate;
(4) merge twice filtrate, be concentrated into relative density 1:1, leave standstill 24 hours, filter, filtrate gets final product subpackage.
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Cited By (2)
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CN105395603A (en) * | 2015-11-23 | 2016-03-16 | 王雅芳 | Formula for reducing blood pressure and making method |
CN107823571A (en) * | 2017-12-06 | 2018-03-23 | 王强 | A kind of Chinese medicine preparation for treating hypertension |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105395603A (en) * | 2015-11-23 | 2016-03-16 | 王雅芳 | Formula for reducing blood pressure and making method |
CN107823571A (en) * | 2017-12-06 | 2018-03-23 | 王强 | A kind of Chinese medicine preparation for treating hypertension |
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