CN104435883A - 一种治疗跟痛症的中药制剂 - Google Patents
一种治疗跟痛症的中药制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗跟痛症的中药制剂,由以下重量配比的药材制备而成:当归6份、川芎6份、骨碎补6份、甘草6份、白芍10份,五加皮30份、生薏仁30份、白千层油15份、牛膝8份、五代同堂根10份、猪牙皂10份、黄腰子蔓5份、鲨鱼肝5份、菥蓂子5份。临床实验证明,本发明通过选择合适的药材及其配比,具有补肾强骨、活络通痹、除湿止痛、驱邪外出之功效,治疗跟痛症治愈率极高且安全无毒副作用。
Description
技术领域
本发明涉及一种中药制剂,具体涉及一种治疗跟痛症的中药制剂。
背景技术
跟痛症主要是指病人在行走或站立时足眼底部疼痛。多由慢性损伤引起,常伴有跟骨结节部的前缘骨刺。本病多发生于中老年人,且为体虚较肥胖的男性,可能与老年退行变有关系。急、慢性损伤,使跖腱膜在跟骨附着处发生劳损,或由它处感染病灶引起跖腱膜炎,也可发病。临床上对该疾病的治疗,一般以西医为主,但是大部分药剂药效不显,对于跟痛症的治疗效果不显著。
发明内容
本发明旨在提供一种治疗跟痛症的中药制剂,其选用药材配伍相宜,符合中医药及现代医学研究理论,具有补肾强骨、活络通痹、除湿止痛、驱邪外出之功效,治疗跟痛症治愈率极高且安全无毒副作用。
为了达到上述目的,本发明采用以下技术方案:一种治疗跟痛症的中药制剂,由以下重量配比的药材制备而成:当归5~7份、川芎5~7份、骨碎补5~7份、甘草5~7份、白芍9~11份,五加皮28~35份、生薏仁28~35份、白千层油14~16份、牛膝7~9份、五代同堂根9~11份、鲨鱼肝4~6份、猪牙皂9~11份、黄腰子蔓4~6份、菥蓂子0~6份。
作为优选,由以下重量配比的药材制备而成:当归5~7份、川芎5~7份、骨碎补5~7份、甘草5~7份、白芍9~11份,五加皮28~35份、生薏仁28~35份、白千层油14~16份、牛膝7~9份、鲨鱼肝4~6份、五代同堂根9~11份、猪牙皂9~11份、黄腰子蔓4~6份。
作为优选,由以下重量配比的药材制备而成:当归5~7份、川芎5~7份、骨碎补5~7份、甘草5~7份、白芍9~11份,五加皮28~35份、生薏仁28~35份、白千层油14~16份、牛膝7~9份、五代同堂根9~11份、猪牙皂9~11份、黄腰子蔓4~6份、鲨鱼肝4~6份、菥蓂子4~6份。
作为优选,由以下重量配比的药材制备而成:当归6~7份、川芎6~7份、骨碎补6~7份、甘草6~7份、白芍10~11份,五加皮30~35份、生薏仁30~35份、白千层油15~16份、牛膝8~9份、五代同堂根10~11份、猪牙皂10~11份、黄腰子蔓5~6份、鲨鱼肝5~6份、菥蓂子5~6份。
作为优选,由以下重量配比的药材制备而成:当归6份、川芎6份、骨碎补6份、甘草6份、白芍10份,五加皮30份、生薏仁30份、白千层油15份、牛膝8份、五代同堂根10份、猪牙皂10份、黄腰子蔓5份、鲨鱼肝5份、菥蓂子5份。
一种治疗跟痛症的中药制剂的制备方法,包括如下步骤:(1)将当归、川芎、骨碎补、甘草、白芍、五加皮、生薏仁、牛膝、五代同堂根、猪牙皂、黄腰子蔓、菥蓂子放入容器内,加入8~10 倍量的蒸馏水,浸泡5~6小时后,煮沸3~4 小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6 倍量蒸馏水,加热煮沸1~2 小时,提取;合并三次提取液,过滤,得滤液备用;(2)将白千层油、鲨鱼肝放入容器内,加入烈性白酒,并加入少量蜂蜜,搅拌均匀,经容器密封,隔水加热15~25min,取出,得膏体备用;(3)将上述步骤(1)~(2)所制得的滤液以及膏体混合,利用现代先进的制药科技,制成胶囊,即得本发明所述的治疗跟痛症的中药制剂。
本发明各中药成份的药理分析如下:
当归【来源】伞形科植物当归的干燥根。【性味】 甘、辛,温。【归经】 归肝、心、脾经。【功能主治】 补血活血,调经止痛,润肠通便。用于血虚萎黄,眩晕心悸,***,经闭痛经,虚寒腹痛,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡。酒当归活血通经。用于经闭痛经,风湿痹痛,跌扑损伤。
川芎【来源】伞形科植物川芎的干燥根茎。【性味】 辛,温。【归经】 归肝、胆、心包经。【功能主治】 活血行气,祛风止痛。
骨碎补【来源】 本品为水龙骨科植物槲蕨的干燥根茎。【性味】 苦,温。【归经】 归肾、肝经。【功能主治】 补肾强骨,续伤止痛。用于肾虚腰痛,耳鸣耳聋,牙齿松动,跌扑闪挫,筋骨折伤;外治斑秃,白癜风。
白芍【性味】 苦、酸,微寒。【归经】 归肝、脾经。【功能主治】 平肝止痛,养血调经,敛阴止汗。用于头痛眩晕,胁痛,腹痛,四肢挛痛,血虚萎黄,***,自汗,盗汗。
五加皮【来源】 本品为五加科植物细柱五加的干燥根皮。【性味】 辛、苦,温。【归经】 归肝、肾经。【功能主治】 祛风湿,补肝肾,强筋骨。用于风湿痹痛,筋骨痿软,小儿行迟,体虚乏力,水肿,脚气。
生薏仁【来源】为禾本科植物薏苡的种仁。【性味】 甘;淡;微寒。【归经】 脾;肺;肾经。【功能主治】 利湿健脾;舒筋除痹;清热排脓。主水肿;脚气;小便淋沥;湿温病;泄泻带下;风湿痹痛;筋脉拘挛;肺痈;肠痈;扁平疣。
牛膝【来源】苋科植物牛膝的干燥根。【功能主治】补肝肾,强筋骨,逐瘀通经,引血下行。用于腰膝酸痛,筋骨无力,经闭症瘕,肝阳眩晕。
五代同堂根【来源】为八角枫科植物阔叶八角枫的根。【性味】 味辛;微苦;性温。【归经】 肝;胃经。【功能主治】 理气活血;祛风除湿。主膨胀胀痛;小儿疳积;风湿骨痛。
猪牙皂【来源】为豆科植物皂荚已衰老或受伤害后所结之果实。秋末,将成熟的果实采下,晒干。【性味】辛咸,温,有毒。【功能主治】 通窍,涤痰,搜风,杀虫。治中风口噤,头风,风痼,喉痹,痰喘,痞满积滞,关格不通,痈肿,疥癞,癣疾,头疮。
黄腰子蔓【来源】为蓼科植物牛皮消蓼的根。【性味】 酸;辛;性凉。【归经】 肺;胃经。【功能主治】 敛肺止咳;行气健胃;祛风除湿。主肺痨咳嗽;痰中带血;百日咳;胃脘胀闷疼痛;风湿痹痛。
菥蓂子【来源】十字花科植物遏蓝菜的种子。【性味】味辛、苦,性微温。【功能主治】清热,滋补,开胃,利尿,消肿。主治肺热、肝热、肾热,肾脉损伤,遗精。阳痿,腰腿痛。
甘草【性味】甘,平。【归经】 归心、肺、脾、胃经。【功能主治】 补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
鲨鱼肝【来源】为六鳃鲨科动物扁头哈那鲨及其他鲨鱼的肝脏或肝脏经提炼而得的鱼肝油。【性味】 味甘;性温。【功能主治】 健脾补气;养肝明目;解毒敛疮。主眼结膜干燥症;夜盲症;软骨病;烫火伤;皮肤溃疡;外伤创面久不愈。
白千层油【来源】为桃金娘科植物白千层的叶或枝蒸取的挥发油。【性味】 味辛;性平。【归经】 归肝;胃;心经。【功能主治】 祛风通络;理气止痛;杀虫。主风湿痹痛;拘挛麻木;脘腹胀痛;牙痛;头痛;疝气痛;跌打肿痛;疥疮。
本发明与现有技术相比,具有以下有益效果:
1、本发明中药制剂具有补肾强骨、活络通痹、除湿止痛、驱邪外出之功效,治疗跟痛症治愈率极高且安全无毒副作用。其中:方中五加皮、骨碎补、牛膝温肾强普填精,强壮筋骨,治风寒湿痹;生薏仁去湿舒筋,治湿痹止痛;当归、白千层油、川芎、白芍、甘草补血行气,祛风除湿,缓筋止痛,治寒痹筋挛;再用鲨鱼肝健脾补气、猪牙皂通窍涤痰,并与五代同堂根、黄腰子蔓、菥蓂子之间相互佐益,诸药合用,既可活血通络,驱邪外出,又可缓解疼痛,减轻症状,改善功能,可谓标本兼治。
2、本发明中药制剂选用优质中药材制成,所选药材配伍相宜,符合中医药及现代医学研究理论,并利用现代医药制药技术制成,安全无毒副作用,达到标本兼治的目的,值得临床推广应用。
具体实施方式
为了更好地理解和实施本发明,下面结合具体实施例进一步说明本发明。
实施例1
称取:当归6克、川芎6克、骨碎补6克、甘草6克、白芍10克,五加皮30克、生薏仁30克、白千层油15克、牛膝8克、五代同堂根10克、猪牙皂10克、黄腰子蔓5克、鲨鱼肝5克、菥蓂子5克,按以下工艺步骤进行制备:(1)将当归、川芎、骨碎补、甘草、白芍、五加皮、生薏仁、牛膝、五代同堂根、猪牙皂、黄腰子蔓、菥蓂子放入容器内,加入8~10 倍量的蒸馏水,浸泡5~6小时后,煮沸3~4 小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6 倍量蒸馏水,加热煮沸1~2 小时,提取;合并三次提取液,过滤,得滤液备用;(2)将白千层油、鲨鱼肝放入容器内,加入烈性白酒,并加入少量蜂蜜,搅拌均匀,经容器密封,隔水加热15~25min,取出,得膏体备用;(3)将上述步骤(1)~(2)所制得的滤液以及膏体混合,利用现代先进的制药科技,制成胶囊,即得本发明所述的治疗跟痛症的中药制剂。
用法用量:口服,每日2次,早晚各1次,每次2粒,饭后温开水送服;2周为1个疗程,连续服用2个疗程。
实施例2
称取:当归5克、川芎5克、骨碎补5克、甘草5克、白芍9克,五加皮28克、生薏仁28克、白千层油14克、牛膝7克、五代同堂根9克、鲨鱼肝4克、猪牙皂9克、黄腰子蔓4克。
本实施例的中药制剂制备方法与实施例1相同。
实施例3
称取:当归7克、川芎7克、骨碎补7克、甘草7克、白芍11克,五加皮35克、生薏仁35克、白千层油16克、牛膝9克、五代同堂根11克、鲨鱼肝6克、猪牙皂11克、黄腰子蔓6克、菥蓂子6克。
本实施例的中药制剂制备方法与实施例1相同。
临床资料:
1、病例选择:
作为治疗跟痛症的中药制剂,选择2010年以来诊治的跟痛症患者92例临床观察。患者均符合跟痛症诊断标准,可以确诊为跟痛症。病人随机分成治疗组和对照组两组,治疗组46例,对照组46例。治疗组和对照组两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。
2、药物选择:
治疗组服用本发明实施例1所制得的中药胶囊制剂,口服,每日2次,早晚各1次,每次2粒,饭后温开水送服;2周为1个疗程,连续服用2个疗程。
对照组口服适络特缓释胶囊,0.25g,每日2次,雷尼替丁胶囊0.15g,每日2次,每服药5天停服2天,再服药。疗程为4周。
3、疗效判定:
(1)治愈:临床症状消失,行走自如;
(2)好转:临床症状减轻,但行走时尚有少许疼痛;
(3)未愈:治疗前后临床症状无改善。
4、结果:
选用本发明实施例1中药胶囊的治疗组中,治愈33例,好转9例,未愈4例,治愈率71.7%,总有效率91.3%。
对照组中治愈12例,好转26例,未愈8例,治愈率26.1%,总有效率82.6%。
以上结果显示,治疗组的治愈率和总有效率明显高于对照组。
显然,本发明的上述实施例仅仅是为清楚地说明本发明所作的举例,而并非是对本发明的实施方式的限定。对于所属领域的普通技术人员来说,在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无法对所有的实施方式予以穷举。凡是属于本发明的技术方案所引伸出的显而易见的变化或变动仍处于本发明的保护范围之列。
Claims (6)
1.一种治疗跟痛症的中药制剂,其特征在于,由以下重量配比的药材制备而成:当归5~7份、川芎5~7份、骨碎补5~7份、甘草5~7份、白芍9~11份,五加皮28~35份、生薏仁28~35份、白千层油14~16份、牛膝7~9份、五代同堂根9~11份、鲨鱼肝4~6份、猪牙皂9~11份、黄腰子蔓4~6份、菥蓂子0~6份。
2.根据权利要求1所述的一种治疗跟痛症的中药制剂,其特征在于,由以下重量配比的药材制备而成:当归5~7份、川芎5~7份、骨碎补5~7份、甘草5~7份、白芍9~11份,五加皮28~35份、生薏仁28~35份、白千层油14~16份、牛膝7~9份、鲨鱼肝4~6份、五代同堂根9~11份、猪牙皂9~11份、黄腰子蔓4~6份。
3.根据权利要求1所述的一种治疗跟痛症的中药制剂,其特征在于,由以下重量配比的药材制备而成:当归5~7份、川芎5~7份、骨碎补5~7份、甘草5~7份、白芍9~11份,五加皮28~35份、生薏仁28~35份、白千层油14~16份、牛膝7~9份、五代同堂根9~11份、猪牙皂9~11份、黄腰子蔓4~6份、鲨鱼肝4~6份、菥蓂子4~6份。
4. 根据权利要求1所述的一种治疗跟痛症的中药制剂,其特征在于,由以下重量配比的药材制备而成:当归6~7份、川芎6~7份、骨碎补6~7份、甘草6~7份、白芍10~11份,五加皮30~35份、生薏仁30~35份、白千层油15~16份、牛膝8~9份、五代同堂根10~11份、猪牙皂10~11份、黄腰子蔓5~6份、鲨鱼肝5~6份、菥蓂子5~6份。
5.根据权利要求1所述的一种治疗跟痛症的中药制剂,其特征在于,由以下重量配比的药材制备而成:当归6份、川芎6份、骨碎补6份、甘草6份、白芍10份,五加皮30份、生薏仁30份、白千层油15份、牛膝8份、五代同堂根10份、猪牙皂10份、黄腰子蔓5份、鲨鱼肝5份、菥蓂子5份。
6.一种治疗跟痛症的中药制剂的制备方法,其特征在于,包括如下步骤:(1)将当归、川芎、骨碎补、甘草、白芍、五加皮、生薏仁、牛膝、五代同堂根、猪牙皂、黄腰子蔓、菥蓂子放入容器内,加入8~10 倍量的蒸馏水,浸泡5~6小时后,煮沸3~4 小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6 倍量蒸馏水,加热煮沸1~2 小时,提取;合并三次提取液,过滤,得滤液备用;
(2)将白千层油、鲨鱼肝放入容器内,加入烈性白酒,并加入少量蜂蜜,搅拌均匀,经容器密封,隔水加热15~25min,取出,得膏体备用;
(3)将上述步骤(1)~(2)所制得的滤液以及膏体混合,利用现代先进的制药科技,制成胶囊,即得本发明所述的治疗跟痛症的中药制剂。
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