CN104435112A - Soothing pill and preparation method thereof - Google Patents
Soothing pill and preparation method thereof Download PDFInfo
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- CN104435112A CN104435112A CN201410760591.2A CN201410760591A CN104435112A CN 104435112 A CN104435112 A CN 104435112A CN 201410760591 A CN201410760591 A CN 201410760591A CN 104435112 A CN104435112 A CN 104435112A
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- radix
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- borneolum syntheticum
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- 239000006187 pill Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 23
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 9
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000012907 honey Nutrition 0.000 claims abstract description 8
- 208000000059 Dyspnea Diseases 0.000 claims abstract description 6
- 206010013975 Dyspnoeas Diseases 0.000 claims abstract description 6
- 208000029078 coronary artery disease Diseases 0.000 claims abstract description 6
- 239000000284 extract Substances 0.000 claims description 21
- 241000180649 Panax notoginseng Species 0.000 claims description 9
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 9
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 8
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 8
- 229940113124 polysorbate 60 Drugs 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 206010040007 Sense of oppression Diseases 0.000 claims description 5
- 230000035807 sensation Effects 0.000 claims description 5
- 208000013220 shortness of breath Diseases 0.000 claims description 5
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 6
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract description 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract description 2
- 240000004534 Scutellaria baicalensis Species 0.000 abstract description 2
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000722948 Apocynum cannabinum Species 0.000 abstract 1
- 206010008469 Chest discomfort Diseases 0.000 abstract 1
- 244000116484 Inula helenium Species 0.000 abstract 1
- 235000002598 Inula helenium Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 238000007670 refining Methods 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 238000002137 ultrasound extraction Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 240000007185 Albizia julibrissin Species 0.000 description 1
- 235000011468 Albizia julibrissin Nutrition 0.000 description 1
- 241000208327 Apocynaceae Species 0.000 description 1
- 241000185686 Apocynum venetum Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 244000272264 Saussurea lappa Species 0.000 description 1
- 235000006784 Saussurea lappa Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940119177 germanium dioxide Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a soothing pill and a preparation method thereof. The preparation method of the soothing pill is characterized by comprising the following steps: taking 50g of dogbane leaves, 20g of scutellaria baicalensis, 250g of salvia miltiorrhiza, 200g of pseudo-ginseng, 200g of borneol (synthetic camphol), 1,000g of cortex albiziae and 200g of elecampane; crushing into crude powder, and putting into a circulating ultrasonic extractor; adding water, germanium powder and Tween 60, carrying out ultrasonic extraction, and carrying out spray drying on jet flow, so as to prepare nano extracting powder; and refining a pill with honey, so as to prepare the soothing pill. The soothing pill is used for treating dyspnea chest discomfort and angor pectoris caused by a coronary heart disease; the curative effect is superior to that of the commercially available soothing pill; and a good effect is obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of heart and relax ball and preparation method thereof.
Background technology
The heart relaxes ball promoting flow of QI and blood, sensible, resolving depression.For the sensation of oppression over the chest with shortness of breath that coronary heart disease causes, angina pectoris.The commercially available heart relaxes ball due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides the high heart of a kind of curative effect to relax ball and preparation method thereof.
Invention embodiment is as follows:
Get Folium Apocyni Veneti 50g, Radix Scutellariae 20g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 200g, Borneolum Syntheticum (borneolum syntheticum) 200g, Cortex Albiziae 1000g, Radix Aucklandiae 200g, is ground into 40 order coarse powder, puts in circulating ultrasonic extractor, add 19200g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, and the obtained heart relaxes ball.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Folium Apocyni Veneti: China's coastal port one ministerial standard.This product is the dried leaves of apocynaceae plant Herba Apocyni veneti Apocynum venetum L..Summer gathers, removing impurity, dry.
Radix Scutellariae: China's coastal port one ministerial standard.This product is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and removing fibrous root and silt, hit rough bark after solarization, dry.
Radix Salviae Miltiorrhizae: China's coastal port one ministerial standard.This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Spring, Qiu Erji excavate, removing silt, dry.
Radix Notoginseng: China's coastal port one ministerial standard.This product is the dry root and rhizome of panax araliaceae plant Punax notoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".
Borneolum Syntheticum (borneolum syntheticum): China's coastal port one ministerial standard.This product is the crisp crystallization of lamellar of water white transparency or white translucent; Gas delicate fragrance, acrid in the mouth, cool; Tool volatility, lights generation dense smoke, and has the flame of band light.This product is easily molten in ethanol, chloroform or ether, almost insoluble in water.Fusing point should be 205-210 DEG C (annex VII C).
Skin Herba Albiziae: China's coastal port one ministerial standard.This product is the dry bark of leguminous plant Herba Albiziae Albizia julibrissin Durazz..Summer, Qiu Erji strip, and dry.
The Radix Aucklandiae: China's coastal port one ministerial standard.This product is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Autumn, season in winter two excavate, removing silt and fibrous root, cutting.Large vertical profile again becomes lobe, hits rough bark after drying.
Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;
Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;
All can buy from pharmaceuticals with the raw material of setting one's heart used by easypro ball and obtain, be not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.
The key equipment that foregoing invention embodiment is mentioned is as follows:
Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,
(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)
Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;
(typical production producer: Nai Nuo bio tech ltd, Beijing)
All can buy from pharmaceuticals with the raw material of setting one's heart used by easypro ball and obtain, all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Detailed description of the invention
Specific embodiments of the invention 1
Get Folium Apocyni Veneti 50g, Radix Scutellariae 20g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 200g, Borneolum Syntheticum (borneolum syntheticum) 200g, Cortex Albiziae 1000g, Radix Aucklandiae 200g, is ground into 40 order coarse powder, puts in circulating ultrasonic extractor, add 19200g water, 4g germanium powder, 6g polysorbate60, select supersonic frequency 50KHz, pressure 0.3Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20g adds appropriate water pill, dry, makes water-honeyed pill, and the obtained heart relaxes ball.
Specific embodiments of the invention 2
Get Folium Apocyni Veneti 50g, Radix Scutellariae 20g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 200g, Borneolum Syntheticum (borneolum syntheticum) 200g, Cortex Albiziae 1000g, Radix Aucklandiae 200g, is ground into 40 order coarse powder, puts in circulating ultrasonic extractor, add 19200g water, 6g germanium powder, 8g polysorbate60, select supersonic frequency 60KHz, pressure 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 50 DEG C, pressure 0.04 Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 30g adds appropriate water pill, dry, makes water-honeyed pill, and the obtained heart relaxes ball.
Specific embodiments of the invention 3
Get Folium Apocyni Veneti 50g, Radix Scutellariae 20g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 200g, Borneolum Syntheticum (borneolum syntheticum) 200g, Cortex Albiziae 1000g, Radix Aucklandiae 200g, is ground into 40 order coarse powder, puts in circulating ultrasonic extractor, add 19200g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, and the obtained heart relaxes ball.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make the heart and to relax ball.Actual effect of the present invention is investigated below with the heart that embodiment 3 the is obtained ball that relaxes:
(1) relax ball and the commercially available heart of embodiment 3 heart relaxes the sensation of oppression over the chest with shortness of breath that pill for curing coronary heart disease causes, angina pectoris clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe the sensation of oppression over the chest with shortness of breath that coronary heart disease causes altogether, angina pectoris case 112 example, 45 years old mean age.Patient is divided into two groups, test group is taken embodiment 3 heart and to be relaxed ball, and matched group is taken traditional heart and to be relaxed ball.
2 efficacy assessment standards
According to new Chinese medicine treatment angina pectoris guideline of clinical investigations tcm syndrome curative effect determinate standard:
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Increase the weight of: tcm clinical practice symptom, sign all have and increase the weight of, syndrome integral reduces < 0.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Relax ball and the commercially available heart of table 1 embodiment 3 heart relaxes ball clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, the heart prepared by the present invention relaxes ball at the sensation of oppression over the chest with shortness of breath that causes for the treatment of coronary heart disease, during angina pectoris, evident in efficacyly to relax ball higher than the commercially available heart, p < 0.05.
Claims (3)
1. treat sensation of oppression over the chest with shortness of breath, an anginal Chinese medicine that coronary heart disease causes, it is characterized in that getting Folium Apocyni Veneti 50g, Radix Scutellariae 20g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 200g, Borneolum Syntheticum (borneolum syntheticum) 200g, Cortex Albiziae 1000g, Radix Aucklandiae 200g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 19200g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, and the obtained heart relaxes ball.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Folium Apocyni Veneti 50g, Radix Scutellariae 20g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 200g, Borneolum Syntheticum (borneolum syntheticum) 200g, Cortex Albiziae 1000g, Radix Aucklandiae 200g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 19200g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, and the obtained heart relaxes ball.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Folium Apocyni Veneti 50g, Radix Scutellariae 20g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 200g, Borneolum Syntheticum (borneolum syntheticum) 200g, Cortex Albiziae 1000g, Radix Aucklandiae 200g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 19200g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, and the obtained heart relaxes ball.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410760591.2A CN104435112A (en) | 2014-12-13 | 2014-12-13 | Soothing pill and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410760591.2A CN104435112A (en) | 2014-12-13 | 2014-12-13 | Soothing pill and preparation method thereof |
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| CN104435112A true CN104435112A (en) | 2015-03-25 |
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| CN201410760591.2A Withdrawn CN104435112A (en) | 2014-12-13 | 2014-12-13 | Soothing pill and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568481A (en) * | 2017-09-28 | 2019-04-05 | 同溢堂药业有限公司 | A kind of Chinese prescription preparation for treating coronary heart disease |
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2014
- 2014-12-13 CN CN201410760591.2A patent/CN104435112A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568481A (en) * | 2017-09-28 | 2019-04-05 | 同溢堂药业有限公司 | A kind of Chinese prescription preparation for treating coronary heart disease |
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