CN104415162B - Treat Chinese medicine composition of leukopenia after chemoradiotherapy and preparation method thereof - Google Patents
Treat Chinese medicine composition of leukopenia after chemoradiotherapy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating leukopenia after chemoradiotherapy and preparation method thereof, belong to the field of Chinese medicines.Chinese medicine composition of the present invention includes the bulk pharmaceutical chemicals of following parts by weight：10 20 parts of Radix Codonopsis, 10 20 parts of Poria cocos, 15 45 parts of rhodiola root, 10 20 parts of the fruit of Chinese wolfberry, 10 20 parts of the fruit of glossy privet, 5 15 parts of HERBA EPIMEDII, 5 15 parts of Semen Cuscutae, 5 15 parts of dried orange peel.Chinese medicine composition of the present invention has strengthening the spleen and replenishing qi; Tianjing Busuiye medicinal, mild in medicine property and, it is not warm not dry the characteristics of; visceral dysfunction can effectively be corrected; the pathological factors such as vital essence virtual loss, improve spiritlessness and weakness, soreness and weakness of waist and knees; receive the symptoms such as poor loose stool; hemopoietic function of bone marrow can be protected, increasing leukocyte, improves chemicotherapy completion rate.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for treating leukopenia after chemoradiotherapy, more particularly to one kind to treat evil
Property tumor chemoradiotherapy after leukopenia Chinese medicine composition, the invention further relates to the preparation method of the Chinese medicine composition, belong to
In the field of Chinese medicines.
Background technology
Tumour is to endanger one of major disease of human health.Shown according to the WHO2003 data announced：2000
The shared malignant tumor patient 10,000,000 in the whole world, wherein male 5,300,000, women 4,700,000；Because of mortality of malignant tumors, person is up to 6,200,000,
The 12% of total death toll is accounted for, in this numeral of developed country up to 25%.In developing country, due to urbanization process plus
It hurry up, the change of life style and eating habit, the therewith generation of closely related tumour also will gradually be transformed into economically developed state
The type of family.If this trend cannot be improved, it is contemplated that the year two thousand twenty, the annual de novo malignancy case in the whole world will reach
15000000.Therapy of combing traditional Chinese and Western medicine malignant tumour is from China's reality, and melting Chinese and western medical science, each advantage is integrated, in having
The cancer preventing and treating road of state's characteristic, advocates the complex treatment of tumour at present, and traditional Chinese medicine conditioning is suffered from by the tumour of operation chemicotherapy
Person's just its more aobvious advantage.This advantage curative effect is caused by by blocking and reversing the pathology link of malignant tumour.
Chemicotherapy category traditional Chinese medicine " sends an expedition against " category, its common toxicity is mainly manifested in two aspects：On the one hand it is
Bone marrow suppression, including Neuroleptic Leukocytopenia, anaemia, decrease of platelet；On the other hand it is gastrointestinal reaction, including loss of appetite, dislikes
The symptoms such as heart vomiting, abdominal distension diarrhea.Almost all of chemotherapeutics has different degrees of bone marrow suppression, due to leukocyte proliferation
Hurry up, short life, thus bone marrow suppression it is impacted it is maximum be leucocyte.Neuroleptic Leukocytopenia, usually influences smoothly completing for chemotherapy,
Even result in severe infections and dead.Bone marrow suppression caused by prevention chemotherapy is to treat the ring that tumor patient is badly in need of blocking and reversing
Section.The general increasing leucocyte Western medicine such as curative effect such as leucogen, batyl alcohol is poor.Granulocyte colony stimulating factor is used for caused by chemotherapy
Leukopenia is quick, makes because Neuroleptic Leukocytopenia is difficult to continue chemotherapy this problem to have obtained significantly solving, but
It is expensive, and the side reaction such as rebound phenomenon and fever, ostalgia occurs for some patients.Much scholars think, granular leukocyte colony
Stimulating factor is used together with chemotherapeutic, the effect of reducing chemotherapy, and has the possibility for stimulating some tumour growths.
The leukopenia of caused by radiotherapy and chemotherapy is mainly presented with having a dizzy spell, spiritlessness and weakness, soreness and weakness of waist and knees, nervous gas
Short, dysphoria insomnia, dynamic then sweating etc., belongs to the traditional Chinese medical science " consumptive disease " category.《Jing Yue's complete work》Say：" all spleen kidney deficiency and debilitating disorder it
People, there is the disease of accumulation more ", illustrate the generation of tumour, the more deficient situation with the presence of internal organs, especially based on spleen kidney deficiency, internal organs
Deficient and functional disturbance or native endowment deficiency are the blastomogenic internal factors of production.Tcm theory thinks, the spleen being the foundation of acquired constitution,
Source of generating QI and blood.Among the five internal organs, it is particularly important that spleen and stomach function, to other four dirty nourishing effects, taste are strong then four dirty
All strong, body function activity remains normal, and taste are decayed, four it is dirty also decline, all kinds of diseases and ailments are by giving birth to.It is insufficiency of the spleen to have during tumor invasion
There are key effect, insufficiency of the spleen then no resource of generating and transforming QI and blood, deficiency of qi and blood then causes body resistance against diseases to decline；In addition the insufficiency of the spleen wet fortune of then water
Change not normal, the turbid interior life of phlegm, hinder QI-blood circulation, cause qi depression to blood stasis, with the passing of time phlegm and blood stasis, is sent out as carcinoma.The kidney being the origin of congenital constitution,
Residence nephroyin and nephroyang, is this yuan of life.Kidney controlling essence storage gives birth to marrow, and marrow is occupied in bone, and then marrow biochemistry is active for kidney essense abundance, and green blood is prosperous
Contain.An important factor for kidney qi weakness is also tumor development.Consumptive disease is mostly speen-kidney dificiency, and tonifying speen and tonifying kidney is the key for the treatment of,
Clinical treatment should pay attention to tonifying both YIN and YANG especially.Healthy tendency is abundant, and with regard to vigorous, marrow hemopoiesis ability also strengthens the vigor of each internal organs organ.
The content of the invention
The purpose of the present invention is a kind of Chinese medicine composition for treating leukopenia after chemoradiotherapy of offer and its preparation side
Method, the present invention is with Radix Codonopsis, Poria cocos, rhodiola root strengthening the spleen and replenishing qi, with the fruit of Chinese wolfberry, the moon that the fruit of glossy privet is nourishing liver and kidney, and with HERBA EPIMEDII, Tu
Sub- warming and invigorating kidney Yang, Psoralen life marrow, with dried orange peel regulating qi-flowing for harmonizing stomach, full presciption medicine it is mild-natured and, it is not warm not dry.Leucocyte subtracts after treatment chemicotherapy
Few disease works well.
In order to achieve the above object, the present invention adopts the following technical scheme that：
Treat the Chinese medicine composition of leukopenia after chemoradiotherapy, it is characterised in that include the original of following parts by weight meter
Expect medicine：10-20 parts of Radix Codonopsis, 10-20 parts of Poria cocos, 15-45 parts of rhodiola root, 10-20 parts of the fruit of Chinese wolfberry, 10-20 parts of the fruit of glossy privet, HERBA EPIMEDII
5-15 parts, 5-15 parts of Semen Cuscutae, 5-15 parts of dried orange peel.
Preferably the parts by weight of each bulk pharmaceutical chemicals are：15 parts of Radix Codonopsis, 15 parts of Poria cocos, 30 parts of rhodiola root, 15 parts of the fruit of Chinese wolfberry, glossy privet
15 parts of son, 10 parts of HERBA EPIMEDII, 10 parts of Semen Cuscutae, 10 parts of dried orange peel.
Radix Codonopsis sweet in flavor and neutral in nature, return lung spleen two pass through,《Herbal justice》Record：Tonifying spleen nourishing the stomach, moistening lung and production of body fluid, gas during tendon is transported, this
It is not very mutually remote with ginseng.Its outstanding valuable person, then invigorating the spleen fortune grow stomach-Yin without wet without dry, moistening lung is cold and cool without violating, blood-nourishing without
Grow partially greasy, inspire clear sun, gas in vibration, and without just dry disadvantage.
Poria cocos is sweet light flat, and invigorating spleen to remove dampness, antitoxic heart-soothing and sedative, is clearing damp panacea, for diarrhea caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, band
Under, there is the effect of giving consideration to both the incidental and fundamental using Poria cocos, often used with Radix Codonopsis mutual reinforcement between, resonate taste vigour, help the foundation of acquired constitution.
Rhodiola root is sweet, bitter, flat, and qi and activate blood circulation, promote blood circulation, for qi deficiency to blood stasis, chest impediment and cardialgia, hemiplegia and burnout god
It is tired to wait disease, Tibetan medicine and pharmacology works is seen earliest《Four doctor's allusion quotations》, there is the laudatory title of " snowy region ginseng ",《Compendium of Materia Medica》Record：This is through upper
Product, eliminating evil, bad odor, mends various symptims and signs of deficiency, is that institute is rare in known tonic, presently mainly improves exempting from for body using rhodiola root
Epidemic disease function, protection and promotion recovery capability, strengthen immunologic cellular activity.By rhodiola root and chemotherapy drugs in combination application, can reduce
The toxicity of chemotherapy, improves chemotherapy effect, can also increase tolerance of the patient to operation, radiotherapy or chemotherapy etc., promotes operation
The recovery of body's immunity afterwards.Modern study proves that rhodioside may stimulate bone marrow suppression by directly or indirectly acting on
The propagation of anemia mice hematopoietic progenitor cells, to promote the recovery of hematopoiesis function.
Fruit of Chinese wolfberry sweet in flavor and neutral in nature, function tonification liver kidney, benefiting shrewd head, for the product of flat kidney tonifying essence liver blood,《Collected statements on the herbal foundation》Carry：
" matrimony vine can be such that gas fills, and blood can be mended, Yang Kesheng, and the moon can be grown, and fire can drop, and rheumatism can be gone, and here have perfect magical effect." modern study
Prove, the fruit of Chinese wolfberry has adjustment effect to immune, and anti-aging is antitumor, protects liver, promotes hematopoiesis function, to normal healthy people
Also there is notable function of increasing leukocyte.
Fruit of glossy privet sweetness and bitterness is cool, the moon that can be tonified the liver and kidney, first recorded in the Eastern Han Dynasty,《Sheng Nong's herbal classic》It is classified as top grade.《Book on Chinese herbal medicine warp
Dredge》Carry：" fruit of glossy privet, smell is all cloudy, is just entering kidney and is removing the product of wanting for vulcanizing essence, and kidney must be mended, then the five internal organs are from pacifying, and spirit is self-sustaining, and all kinds of diseases and ailments are gone
And body fertilizer is strong.”
HERBA EPIMEDII, that is, Herba Epimedii, property acrid-sweet flavor temperature, has tonifying kidney and strengthening yang, strengthening the bones and muscles, the effect of dispelling wind and eliminating dampness.《This warp》It is first
Carry " benefiting energy, strong will ", Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》The middle work(for claiming it to have " strengthening the essence gas, hard muscles and bones, mends waist and knee, cardiac stimulant power "
Effect.Modern pharmacology experimental study shows that Herba Epimedii can promote hematopoiesis function, immune function and bone metabolism, has anti-aging, resists and swell
Knurl and other effects.
Semen Cuscutae property acrid-sweet flavor is put down, and tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity.This product is pungent to moisturize, sweet with qi-restoratives, for flat tonifying yin sun
Product, function kidney-replenishing, kidney-nourishing essence, invigorating the spleen.According to《Japan hanako materia medica》：General debility is mended, controls and lets out essence, hematuria, embellish lung.
Dried orange peel nature and flavor are worked hard temperature, and returns spleen lung channel, regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm, and the pungent row temperature of this product is logical, there is regulating qi-flowing for relieving pain invigorating the spleen
Work(with, it is pungent fragrant and go, it is apt to regulating functional activities of vital QI, orderly and clearly middle Jiao, and make lifting orderly, to treat vomiting hiccup.《Collected statements on the herbal foundation》
Middle load：Acrid flavour is apt to dissipate, therefore can open gas；Stomach hardship, which is opened, lets out, therefore can manage it phlegm；Its temperature is put down, be good at it is sensible, therefore can preventing or arresting vomiting, cough-relieving, invigorating the spleen
With stomach person.
Full side's monarch, methodically, had not only closed ancient method, but also have new meaning.Above medicine melts tonifying yin yang-tonifying in one, embodies
Interdependence between yin and yang, the meaning of cloudy rising Yang length.Radix Codonopsis, Poria cocos strengthening the spleen and replenishing qi, can not only improve spontaneous perspiration, weak symptom, but also can promote appetite,
Improve blood tonification effect；The moon that the fruit of Chinese wolfberry, the fruit of glossy privet are nourishing liver and kidney, blood-nourishing；HERBA EPIMEDII, Semen Cuscutae warming and invigorating kidney Yang, it is warm but not dry,
Dried orange peel regulating qi-flowing for strengthening spleen and stomach, had both helped medicine row, it is antimagnetic it is greasy hinder stomach, and can effectively alleviate the bad anti-of the digestive system of caused by radiotherapy and chemotherapy
Should.This side's negative and positive of qi and blood, liver and spleen kidney are all mended, in addition to notable function of increasing leukocyte, to alleviating spiritlessness and weakness, soreness and weakness of waist and knees, the heart
Throb with fear the clinical symptoms such as insomnia, spontaneous sweating, have a better effect, and without side reaction.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, and each bulk pharmaceutical chemicals are weighed by the parts by weight, will be each
Bulk pharmaceutical chemicals crush, and sieving, addition prepares various auxiliary materials required during different dosage forms, such as disintegrant, lubricant, binder etc.,
The suitable clinical preparation of any type is prepared into conventional method of Chinese medicinal, for example, can be capsule, pill, powder,
Granule, tablet, oral liquid or pill etc., are preferably granule.
Preferably, a kind of method for preparing Chinese medicine composition of the present invention, comprises the following steps：
（1）Each bulk pharmaceutical chemicals are weighed by the parts by weight；
（2）HERBA EPIMEDII, rhodiola root, dried orange peel are distilled respectively, volatile oil is extracted, is crushed after volatile oil is coated with, it is spare；
（3）With volume fraction it is that 30-95% ethanol extracts by Radix Codonopsis, the fruit of Chinese wolfberry, the fruit of glossy privet, ethanol extract is sprayed dry
It is dry, it is spare；
（4）By extract volatile oil after HERBA EPIMEDII, rhodiola root, the dried orange peel dregs of a decoction and Radix Codonopsis, matrimony vine, the fruit of glossy privet, Poria cocos, Tu
Son one reinstates water extraction, and aqueous extract is spray-dried, spare；
（5）By step（2）、（3）With（4）Obtained product is uniformly mixed, and is added pharmaceutical preparation auxiliary materials and mixing and is made
Agent semi-finished product, then finished dosage form is made through preparations shaping technique.
Preferably, above-mentioned steps（3）Described in ethanol select volume fraction be 95% ethanol, ethanol add weight be
3-5 times of the medicine gross weight, is extracted 2-4 times, when extraction 1.5-2.5 is small every time.
Preferably, above-mentioned steps（4）It is middle secondary with water extraction, add the 3-5 that water weight is the medicine gross weight for the first time
Times, decoct 2-4 it is small when, second plus water weight be 1.5-3 times of the medicine gross weight, when decoction 0.5-1.5 is small.
In addition, the Chinese medicine composition of the invention prepared is further included in treatment leukopenia after chemoradiotherapy medicine is prepared
Purposes.
Chinese medicine composition of the present invention has protection marrow, raises leucocyte during malignant tumor patient chemicotherapy, and enhancing is suffered from
Person's immunity of organisms, improves gastrointestinal function, mitigates chemicotherapy adverse reaction so as to reach, improves the purpose of chemicotherapy completion rate.
And Chinese medicine composition Clinical practice safety of the present invention, without any adverse reaction after patient's use, and it can effectively improve the complete of patient
Body function, any adverse reaction will not be produced after disabling medicine of the present invention.
Embodiment
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.But embodiment is only exemplary, does not form any restrictions to the scope of the present invention.Those skilled in the art should
It should be appreciated that the details and form of technical solution of the present invention can be repaiied without departing from the spirit and scope of the invention
Change or replace, but these modifications and replacement are each fallen within protection scope of the present invention.
The preparation of 1 hard capsule of embodiment
（1）Each raw material medicine materical crude slice is weighed by following weight：Radix Codonopsis 1500g, Poria cocos 1500g, rhodiola root 3000g, the fruit of Chinese wolfberry
1500g, fruit of glossy privet 1500g, HERBA EPIMEDII 1000g, Semen Cuscutae 1000g, dried orange peel 1000g.
（2）By rhodiola root, HERBA EPIMEDII, dried orange peel distillation, volatile oil is extracted, takes rhodiola root, HERBA EPIMEDII, 10 times of Pericarpium Citri Reticulatae volatile oil
After the beta-cyclodextrin of amount, after adding the ethanol mixing that the volume fraction that 3 times of beta-cyclodextrin is measured is 40%, with colloid mill homogeneous 15
Minute included, by the homogenizing fluid refrigeration 24 after inclusion it is small when after filter, the inclusion compound after filtration is dried at a temperature of 40 DEG C
After crush, it is spare；
（3）Radix Codonopsis, the fruit of glossy privet, fruit of Chinese wolfberry volume fraction are extracted for 95% ethanol, it is the medicine that ethanol, which adds weight,
4 times of gross weight, are extracted 3 times, when extraction 2 is small every time, merge extracting solution, filtration, filtrate is concentrated into relative density 1.30-1.35
（55 DEG C Celsius）Clear cream, spray drying prepares fine powder, spare；
（4）By extract volatile oil after HERBA EPIMEDII, rhodiola root, the dried orange peel dregs of a decoction and Radix Codonopsis, matrimony vine, the fruit of glossy privet, Poria cocos, Tu
Son one reinstates that water extraction is secondary, and for the first time plus water weight is 4 times of the medicine gross weight, decoct 3 it is small when, second plus water weight
Amount is 2 times of the medicine gross weight, when decoction 1 is small；Decoction liquor it will merge twice, filtration, filtrate is concentrated into relative density and is
1.30-1.35（55 DEG C Celsius）Clear cream, spray drying prepares fine powder, spare；
（5）By step（2）、（3）With（4）Obtained product is uniformly mixed, and adds dextrin, appropriate Flos Chrysanthemi total glycosides, is mixed,
Add appropriate amount of ethanol that particle is made, low temperature drying is spare；
（6）Will（5）The dry particle of middle preparation carries out whole grain, is prepared into single-size, spare；
（7）Will（6）The single-size of middle preparation, is filled in hard capsule case with capsule automatic filling machine, spare；
（8）Will（7）In hard shell capsules be polished or seal, to obtain the final product.
The preparation of 2 powder of embodiment
Each bulk pharmaceutical chemicals are weighed by following weight：Radix Codonopsis 1500g, Poria cocos 1500g, rhodiola root 3000g, fruit of Chinese wolfberry 1500g, female
Loyal sub- 1500g, HERBA EPIMEDII 1000g, Semen Cuscutae 1000g, dried orange peel 1000g；After above-mentioned each bulk pharmaceutical chemicals are crushed, 800 mesh sieves are crossed, i.e.,
.
The preparation of 3 granule of embodiment
（1）Each raw material is weighed by following weight：Radix Codonopsis 1500g, Poria cocos 1500g, rhodiola root 3000g, fruit of Chinese wolfberry 1500g,
Fruit of glossy privet 1500g, HERBA EPIMEDII 1000g, Semen Cuscutae 1000g, dried orange peel 1000g；
（2）By rhodiola root and HERBA EPIMEDII, dried orange peel extraction volatile oil, crushes after volatile oil is coated with, spare；
（3）By Radix Codonopsis, the fruit of glossy privet, the fruit of Chinese wolfberry, Semen Cuscutae volume fraction are extracted for 95% ethanol, and ethanol, which adds weight, is
4 times of the medicine gross weight, are extracted 3 times, when extraction 2 is small every time, merge extracting solution, filtration, filtrate is concentrated into relative density
1.30-1.35（55 DEG C Celsius）Clear cream, spray drying prepares fine powder, spare；
（4）By extract volatile oil after HERBA EPIMEDII, rhodiola root, the dried orange peel dregs of a decoction and Radix Codonopsis, matrimony vine, the fruit of glossy privet, Poria cocos, Tu
Son one reinstates that water extraction is secondary, and for the first time plus water weight is 3 times of the medicine gross weight, decoct 3 it is small when, second plus water weight
Amount is 2 times of the medicine gross weight, when decoction 1 is small；Decoction liquor it will merge twice, filtration, filtrate is concentrated into relative density and is
1.30-1.35（55 DEG C Celsius）Clear cream, spray drying prepares fine powder, spare；
（5）By step（2）、（3）With（4）Obtained product is uniformly mixed, and adds dextrin, appropriate Flos Chrysanthemi total glycosides, is mixed,
Add appropriate amount of ethanol that particle is made, after low temperature drying, whole grain, packing, to obtain the final product.
Test example 1：Malignant tumor chemotherapy causes leukopenia patient's observation of curative effect
1st, data and method
1.1 case sources
In January, 2009~2012 year Changzhou in December tumour hospital, outpatient service and Tumor Patients Hospitalized amount to 100.Patient
It is randomly divided into Chinese herbs group 50, control group 50.In Chinese herbs group, man 22, female 28；Age 31-75 Sui, middle position
56 years old age, wherein lung cancer 8,20 cases of breast cancer, the cancer of the esophagus 3, stomach cancer 10, colorectal cancer 6, cervical carcinoma 3.Control group
In, male 24, female 26；Age 32-75 Sui, the median age 55 years old；Wherein lung cancer 9, mammary cancer 16, the cancer of the esophagus 4, stomach
Cancer 10, colorectal cancer 6, cervical carcinoma 5.Two groups of Genders, the age, histological type and by stages, chemotherapy proleukocyte count
And neutrophil leucocyte number no difference of science of statistics, it is comparable.Above case is through proved by pathology.Laboratory examination leucocyte is equal
Less than 4 × 109A/L, meets leukopenia standard.
1.2 treatment method
Treatment group：From plan prescription：Radix Codonopsis 15g, Poria cocos 15g, rhodiola root 30g, fruit of Chinese wolfberry 15g, fruit of glossy privet 15g, celestial spirit
Spleen 10g, Semen Cuscutae 10g, dried orange peel 10g days are one, and decocting twice, takes juice 400ml, take at twice sooner or later altogether.Control group：Select and rise
Baiyao：Batyl alcohol 20mg, leucogen 20mg, adenine phosphate 20mg are given every time, 3 times a day.The course for the treatment of：Two groups equal 10 days be 1
The course for the treatment of, the course for the treatment of terminate routine of having a blood test, and count curative effect.All cases leucocyte 3.0-4.0 × 109A/L does not stop chemotherapy, leucocyte
Less than 3.0 × 109A/L stops chemotherapy.Reinforced battalion is supported during medication, feeds high protein, high fat diet, prevention infection.
1.3 criterion of therapeutical effect：
Worked out with reference to the Ministry of Public Health《Clinical drug studies guideline》Middle drug for increasing white cells criterion of therapeutical effect.It is effective：Treatment
Total white blood cells rises to 4.0 × 10 afterwards9A/more than L, and curative effect can be maintained until 1 week after being discontinued in the course for the treatment of, clinical symptoms are shown
Write and mitigate or disappear；Effectively：Leucocyte after treatment<4.0×109A/L, but rise 0.5 × 10 before relatively treating9-1.0×109A/
L, and curative effect can be maintained until 1 week after being discontinued in the course for the treatment of, clinical symptoms improve；It is invalid：Total white blood cells rises after treatment<
0.5×109A/L, clinical symptoms are without improvement.
2nd, treatment results
Treatment group 50, effective 35, effective 11, invalid 4, total effective rate 92%；Control group 50, effective 18
Example, effective 17, invalid 15, total effective rate 70%；Two groups of curative effects have been statistically analyzed significant difference（P<0.05）.
Improve obvious for symptom, treatment groups such as patient's subjective symptoms is dizzy, weak, spontaneous perspiration, poor, the sleep differences of appetite.
3rd, conclusion
Chinese medicine composition prepared by the present invention has protection marrow, raises leucocyte during Chemotherapy in Malignant Carcinoma Patients, increases
Strong patient's immunity of organisms, improves gastrointestinal function, so as to reach mitigation chemotherapy adverse effect, improves the purpose of chemotherapy completion rate.
Claims (9)
1. treat the Chinese medicine composition of leukopenia after chemoradiotherapy, it is characterised in that by the bulk pharmaceutical chemicals of following parts by weight meter
Composition：10-20 parts of Radix Codonopsis, 10-20 parts of Poria cocos, 15-45 parts of rhodiola root, 10-20 parts of the fruit of Chinese wolfberry, 10-20 parts of the fruit of glossy privet, HERBA EPIMEDII
5-15 parts, 5-15 parts of Semen Cuscutae, 5-15 parts of dried orange peel.
2. Chinese medicine composition according to claim 1, it is characterised in that the parts by weight of each bulk pharmaceutical chemicals are：15 parts of Radix Codonopsis, Fu
15 parts of Siberian cocklebur, 30 parts of rhodiola root, 15 parts of the fruit of Chinese wolfberry, 15 parts of the fruit of glossy privet, 10 parts of HERBA EPIMEDII, 10 parts of Semen Cuscutae, 10 parts of dried orange peel.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that be prepared into according to Chinese medicine preparation and clinically fit
Suitable preparation.
4. Chinese medicine composition described in accordance with the claim 3, it is characterised in that the preparation includes capsule, pill, dissipates
Agent, granule, tablet, oral liquid or pill.
5. a kind of method for preparing the Chinese medicine composition described in claim 1 or 2, its step include：Weighed by the parts by weight
Each bulk pharmaceutical chemicals, each bulk pharmaceutical chemicals are crushed, and sieving, adds the auxiliary material or excipients needed for preparations shaping, be prepared into capsule, ball
Agent, powder, granule, tablet, oral liquid or pill.
6. a kind of method for preparing the Chinese medicine composition described in claim 1 or 2, its step include：
(1) each bulk pharmaceutical chemicals are weighed by the parts by weight；
(2) HERBA EPIMEDII, rhodiola root, dried orange peel are distilled respectively, extracts volatile oil, crushed after volatile oil is coated with, it is spare；
(3) it is that 30-95% ethanol extracts with volume fraction by Radix Codonopsis, the fruit of Chinese wolfberry, the fruit of glossy privet, ethanol extract is spray-dried,
It is spare；
(4) by HERBA EPIMEDII, rhodiola root, the dried orange peel dregs of a decoction and the Radix Codonopsis after extraction volatile oil, matrimony vine, the fruit of glossy privet, Poria cocos, Semen Cuscutae one
Water extraction is reinstated, aqueous extract is spray-dried, it is spare；
(5) step (2), (3) and (4) obtained product is uniformly mixed, adds pharmaceutical preparation auxiliary materials and mixing and preparation half is made
Finished product, then finished dosage form is made through preparations shaping technique.
7. preparation method according to claim 6, it is characterised in that the ethanol described in the step (3) selects volume
Fraction is 95% ethanol, and ethanol adds 3-5 times that weight is the medicine gross weight, extracts 2-4 times, extract 1.5- every time
2.5 it is small when.
8. preparation method according to claim 6, it is characterised in that the number extracted in the step (4) with water is two
Secondary, first time adds 3-5 times that water weight is the medicine gross weight, and when decoction 2-4 is small, for the second time plus water weight is the medicine
1.5-3 times of gross weight, when decoction 0.5-1.5 is small.
9. the Neuroleptic Leukocytopenia disease drug after treatment concurrent chemoradiotherapy of malignant tumor is prepared of the Chinese medicine composition described in claim 1 or 2
In purposes.
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| CN1306848A (en) * | 2000-01-26 | 2001-08-08 | 中国石化集团齐鲁石油化工公司 | Chinese medicine preparation for preventing and treating leucocytopenia and its preparation process |
| EP1138692A1 (en) * | 2000-03-29 | 2001-10-04 | Erasmus Universiteit Rotterdam | Fragments of human chorionic gonadotropin (hcg) as immunoregulator |
| CN1833695A (en) * | 2006-01-11 | 2006-09-20 | 重庆希尔安药业有限公司 | Tonifying speen and tonifying kidney granular and its prepn. method |
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| CN1306848A (en) * | 2000-01-26 | 2001-08-08 | 中国石化集团齐鲁石油化工公司 | Chinese medicine preparation for preventing and treating leucocytopenia and its preparation process |
| EP1138692A1 (en) * | 2000-03-29 | 2001-10-04 | Erasmus Universiteit Rotterdam | Fragments of human chorionic gonadotropin (hcg) as immunoregulator |
| CN1833695A (en) * | 2006-01-11 | 2006-09-20 | 重庆希尔安药业有限公司 | Tonifying speen and tonifying kidney granular and its prepn. method |
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